MOLECULAR AND CELLULAR Volume 8 January 1988 No. 1

Comparison of Nonerythroid a-Spectrin Genes Reveals Strict Homology among Diverse Species. Thomas L. Leto, Donna Fortugno-Erikson, David Barton, Teresa L. Yang-Feng, Uta Francke, Alan S. Harris, Jon S. Morrow, V. T. Marchesi, and Edward J. Benz, Jr...... 1-9 Effect of Synthesis Inhibition on Gene Expression during Early Develop- ment of Dictyostelium discoideum. C. K. Singleton, S. S. Manning, and Y. Feng ...... 10-16 Preferential Amplification of Rearranged Sequences near Amplified Adenylate De- aminase Genes. Michelle Debatisse, Izumu Saito, Gerard Buttin, and George R. Stark ...... 17-24 Expression and Biosynthetic Variation of the Epidermal Growth Factor Receptor in Human Hepatocellular Carcinoma-Derived Cell Lines. Cathleen R.

Carlin, Daniela Simon, James Mattison, and Barbara B. Knowles ...... 25-34 Both Upstream and Intron Sequence Elements Are Required for Elevated Expres- sion of the Rat Somatic Cytochrome c Gene in COS-1 Cells. Mark J. Evans and Richard C. Scarpulla ...... 35-41 Hepatocyte-Stimulating Factor, 12 Interferon, and Interleukin-1 Enhance Expres- sion of the Rat a1-Acid Glycoprotein Gene via a Distal Upstream Regulatory Region. Karen R. Prowse and Heinz Baumann ...... 42-51 An Adenylate Cyclase from Saccharomyces cerevisiae That Is Stimulated by RAS with Effector Mutations. Mark S. Marshall, Jackson B. Gibbs, Edward M. Scolnick, and Irving S. Sigal ...... 52-61 The Muscle Creatine Kinase Gene Is Regulated by Multiple Upstream Elements, Including a Muscle-Specific Enhancer. James B. Jaynes, Jane E. Johnson, Jean N. Buskin, Cyndy L. Gartside, and Stephen D. Hauschka ...... 62-70 DNase I- and Micrococcal Nuclease-Hypersensitive Sites in the Human Apolipo- protein B Gene Are Tissue Specific. Beatriz Levy-Wilson, Craig Fortier, Brian D. Blackhart, and Brian J. McCarthy ...... 71-80 The Cell-Specific Enhancer of the Mouse Transthyretin (Prealbumin) Gene Binds a Common Factor at One Site and a Liver-Specific Factor(s) at Two Other Sites. Robert H. Costa, Eseng Lai, Dennis R. Grayson, and James E.

Darnell, Jr ...... 81-90 Effect of Heat Shock on Ribosome Synthesis in Drosophila melanogaster. Jeffrey Bell, Lorna Neilson, and Maria Pellegrini ...... 91-95 Location and Characterization of Two Widely Separated Glucocorticoid Response Elements in the Phosphoenolpyruvate Carboxykinase Gene. Dan D. Petersen, Mark A. Magnuson, and Daryl K. Granner ...... 96-104 DNA Affinity Labeling of Adenovirus Type 2 Upstream Promoter Sequence-Bind- ing Factors Identifies Two Distinct Proteins. Brian Safer, Roger B. Cohen, Susan Garfinkel, and John A. Thompson ...... 105-113 The Site-Specific Ribosomal DNA Insertion Element RlBm Belongs to a Class of Non-Long-Terminal-Repeat Retrotransposons. Yue Xiong and Thomas H. Eickbush ...... 114-123

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Complex Translocation Disrupts c-myc Regulation in a Human Plasma Cell Myeloma. Gregory F. Hollis, Adi F. Gazdar, Virginia Bertness, and Ilan R. Kirsch ...... 124-129 A Novel In Vivo Transcription Assay Demonstrates the Presence of Globin-Induc- ing trans-Acting Factors in Uninduced Murine Erythroleukemia Cells. N. Wrighton and F. Grosveld ...... 130-137 Transformation by the src Oncogene Alters Glucose Transport into Rat and Chicken Cells by Different Mechanisms. Martyn K. White and Michael J. Weber ...... 138-144 Identification and Characterization of Two Functional Domains within the Murine Heavy-Chain Enhancer. Megerditch Kiledjian, Li-Kuo Su, and Tom Kadesch ...... 145-152 A Developmentally Regulated Membrane Protein Gene in Dictyostelium discoi- deum Is Also Induced by Heat Shock and Cold Shock. Markus Maniak and Wolfgang Nellen ...... 153-159 Cloning and Characterization of a cDNA Encoding Transformation-Sensitive Tropomyosin Isoform 3 from Tumorigenic Human Fibroblasts. Ching-Shwun Lin and John Leavitt ...... 160-168 The Accumulation of Three Yeast Ribosomal Proteins under Conditions of Excess mRNA Is Determined Primarily by Fast Protein Decay. Emmanuel Maicas, Fred G. Pluthero, and James D. Friesen ...... 169-175 Tyrosine Phosphorylations In Vivo Associated with v-fms Transformation. Deborah K. Morrison, Philip J. Browning, Morris F. White, and Thomas M. Roberts ...... 176-185 Structure and Expression of the Human L-myc Gene Reveal a Complex Pattern of Alternative mRNA Processing. Frederic Kaye, James Battey, Marion Nau, Burke Brooks, Eric Seifter, Jacques De Greve, Michael Birrer, Edward Sausville, and John Minna ...... 186-195 Carcinogens Can Induce Homologous Recombination between Duplicated Chro- mosomal Sequences in Mouse L Cells. Yenyun Wang, Veronica M. Maher, R. Michael Liskay, and J. Justin McCormick ...... 196-202 Regulation of Rat Liver Maturation In Vitro by Glucocorticoids. Janice Yang Chou, Yu-Jui Yvonne Wan, and Takeshi Sakiyama ...... 203-209 Two DNA-Binding Factors Recognize Specific Sequences at Silencers, Upstream Activating Sequences, Autonomously Replicating Sequences, and Telomeres in Saccharomyces cerevisiae. Andrew R. Buchman, William J. Kimmerly, Jasper Rine, and Roger D. Kornberg ...... 210-225 Sedimentation Analysis of Polyadenylation-Specific Complexes. Claire L. Moore, Hagit Skolnik-David, and Phillip A. Sharp ...... 226-233 Recombinants within the Tyrosine Kinase Region of v-abl and v-src Identify a v-abl Segment That Confers Lymphoid Specificity. Bernard Mathey-Prevot and ...... 234-240 A 29-Nucleotide DNA Segment Containing an Evolutionarily Conserved Motif Is Required in cis for Cell-Type-Restricted Repression of the Chicken oa-Smooth Muscle Actin Gene Core Promoter. Steven L. Carroll, Derk J. Bergsma, and Robert J. Schwartz ...... 241-250 Developmentally Controlled Telomere Addition in Wild-Type and Mutant Paramecia. James D. Forney and Elizabeth H. Blackburn ...... 251-258

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Primary Structure of the Human fgr Proto-Oncogene Product p55c.fgr. Shigeru Katamine, Vicente Notario, C. Durga Rao, Toru Miki, Marc S. C. Cheah, Steven R. Tronick, and Keith C. Robbins...... 259-266 Identification of the Human P-Actin Enhancer and Its Binding Factor. Takeshi Kawamoto, Kozo Makino, Hideo Niwa, Hirotaka Sugiyama, Sigenobu Kimura, Mitsuko Amemura, Atsuo Nakata, and Takeo Kakunaga ...... 267-272 Distinct Binding Sites for Zinc and Double-Stranded RNA in the Reovirus Outer Capsid Protein c3. Leslie A. Schiff, Max L. Nibert, Man Sung Co, Earl G. Brown, and Bernard N. Fields ...... 273-283 The 5' Untranslated Sequence of the c-sis/Platelet-Derived Growth Factor 2 Tran- script Is a Potent Translational Inhibitor. C. Durga Rao, Michael Pech, Keith C. Robbins, and Stuart A. Aaronson ...... 284-292 Differential Regulation of the Yeast CDC7 Gene during Mitosis and Meiosis. Robert A. Sclafani, Mark Patterson, John Rosamond, and Walton L. Fangman ...... 293-300 Identification of a Common Ecotropic Viral Integration Site, Evi-l, in the DNA of AKXD Murine Myeloid Tumors. Michael L. Mucenski, Benjamin A. Taylor, James N. Ihle, Janet W. Hartley, Herbert C. Morse 111, Nancy A. Jenkins, and Neal G. Copeland ...... 301-308 Identification of a DNA Segment That Is Necessary and Sufficient for a-Specific Gene Control in Saccharomyces cerevisiae: Implications for Regulation of a- Specific and a-Specific Genes. Eric E. Jarvis, David C. Hagen, and George F. Sprague, Jr...... 309-320 The C-Terminal Domain of the Largest Subunit of RNA Polymerase II of Saccha- romyces cerevisiae, Drosophila melanogaster, and : a Conserved Structure with an Essential Function. Lori A. Allison, Jerry K.-C. Wong, V. Danial Fitzpatrick, Matthew Moyle, and C. James Ingles ...... 321-329 Genetic Analysis of the Repetitive Carboxyl-Terminal Domain of the Largest Subunit of Mouse RNA Polymerase 11. Marisa S. Bartolomei, Nancy F. Halden, Catherine Ruta Cullen, and Jeifry L. Corden ...... 330-339 Transcriptional and Posttranscriptional Control of c-fos Gene Expression in Human Monocytes. Eric Sariban, Robert Luebbers, and Donald Kufe .... 340-346 Induction of Mutation in Mouse FM3A Cells by N4-Aminocytidine-Mediated Replicational Errors. Mitsuko Takahashi, Masahiko Nishizawa, Kazuo

Negishi, Fumio Hanaoka, Masa-atsu Yamada, and Hikoya Hayatsu ...... 347-352 A Specific Domain of the Adenovirus EIV Promoter Is Necessary To Maintain Susceptibility of the Integrated Promoter to EIA Transactivation. Takashi Nishigaki, Satoko Hanaka, Robert E. Kingston, and Hiroshi Handa ...... 353-360 Saccharomyces cerevisiae SUP53 tRNA Gene Transcripts Are Processed by Mammalian Cell Extracts In Vitro but Are Not Processed In Vivo. Subinay Ganguly, Phillip A. Sharp, and Uttam L. RajBhandary ...... 361-370 A Highly Evolutionarily Conserved Mitochondrial Protein Is Structurally Related to the Protein Encoded by the Escherichia coli groEL Gene. Thomas W. McMullin and Richard L. Hallberg ...... 371-380 Detection of Two Tissue-Specific DNA-Binding Proteins with Affinity for Sites in the Mouse P-Globin Intervening Sequence 2. Deborah L. Galson and David E. Housman ...... 381-392 Complex Regulation of Heat Shock- and Glucose-Responsive Genes in Human Cells. Stephanie S. Watowich and Richard I. Morimoto ...... 393-405

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Regulated Expression of a Transfected Human Cardiac Actin Gene during Differ- entiation of Multipotential Murine Embryonal Carcinoma Cells. Michael A. Rudnicki, Martha Ruben, and Michael W. McBurney ...... 406-417 Functional Modification of a 21-Kilodalton G Protein when ADP-Ribosylated by Exoenzyme C3 of Clostridium botulinum. Eric J. Rubin, D. Michael Gill, Patrice Boquet, and Michel R. Popoff...... 418-426 mRNA Stability Plays a Major Role in Regulating the Temperature-Specific Expression of a Tetrahymena thermophila Surface Protein. Harold D. Love, Jr., Averie Allen-Nash, Qian Zhao, and Gary A. Bannon ...... 427-432 Human hTMa Gene: Expression in Muscle and Nonmuscle Tissue. A. R. MacLeod and C. Gooding ...... 433-440 6;7 Chromosomal Translocation in Spontaneously Arising Rat Immunocytomas: Evidence for c-myc Breakpoint Clustering and Correlation between Isotypic Expression and the c-myc Target. Warren S. Pear, Gunilla Wahlstr0m, Stanley F. Nelson, Hakan Axelson, Anna Szeles, Francis Wiener, Herve Bazin, George Klein, and Janos Sumegi ...... 441-451 Production and Characterization of Biologically Active Recombinant Beta Nerve Growth Factor. Finn Hallbook, Ted Ebendal, and Hakan Persson ...... 452-456 Herpes Simplex Virus-Mediated Human Hypoxanthine-Guanine Phosphoribosyl- transferase Gene Transfer into Neuronal Cells. Thomas D. Palella, Larry J. Silverman, Christopher T. Schroll, Fred L. Homa, Myron Levine, and William N. Kelley...... 457-460 Phosphorylation of p53 in Normal and Simian Virus 40-Transformed NIH 3T3 Cells. David W. Meek and Walter Eckhart ...... 461-465 SRa Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat. Yutaka Takebe, Motoharu Seiki, Jun-ichi Fujisawa, Pamala Hoy, Kyoko Yokota, Ken-ichi Arai, Mitsuaki Yoshida, and Naoko Arai ...... 466-472 Multiple Regulatory Domains in the Mouse Mammary Tumor Virus Long Termi- nal Repeat Revealed by Analysis of Fusion Genes in Transgenic Mice. Timothy A. Stewart, Philip G. Hollingshead, and Sharon L. Pitts ...... 473-479 Evidence that the Functional ,-Actin Gene Is Single Copy in Most Mice and Is Associated with 5' Sequences Capable of Conferring Serum- and Cyclohexi- mide-Dependent Regulation. Paula K. Elder, Chris L. French, M. Subramaniam, Lucy J. Schmidt, and Michael J. Getz ...... 480-485 Sequence and Expression of a Type II , K5, in Human Epidermal Cells. Robert Lersch and Elaine Fuchs ...... 486-493 The Cap of Both Miniexon-Derived RNA and mRNA of Trypanosomes Is 7-Methylguanosine. Richard E. Sutton and John C. Boothroyd ...... 494-496 Augmented Mitogenic Responsiveness to Epidermal Growth Factor in Murine Fibroblasts That Overexpress pp6O-src. Deirdre K. Luttrell, Louis M. Luttrell, and Sarah J. Parsons ...... 497-501 Developmental Expression of Two Forms of pp6O-src in Mouse Brain. Otmar D. Wiestler and Gernot Walter ...... 502-504 SRAS Encodes the Low-Km Cyclic AMP Phosphodiesterase of Saccharomyces cerevisiae. Robert B. Wilson and Kelly Tatchell ...... 505-510 Transfection of an Immunoglobulin K Gene into Mature Human B Lymphocytes. Le thi Bich-Thuy and Cary Queen ...... 511-513

Continued on following page Continuedfrom preceding page ERRATUM Molecular Cloning and Sequence of a Cholesterol-Repressible Enzyme Related to Prenyltransferase in the Isoprene Biosynthetic Pathway. Catherine F. Clarke, Richard D. Tanaka, Karen Svenson, Maria Wamsley, Alan M. Fogelman, and Peter A. Edwards ...... 514

Date of Issue: 30 December 1987

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