molecules Review Peptides from Natural or Rationally Designed Sources Can Be Used in Overweight, Obesity, and Type 2 Diabetes Therapies Mayara C. F. Gewehr 1, Renata Silverio 2, José Cesar Rosa-Neto 3 , Fabio S. Lira 4, Patrícia Reckziegel 5 and Emer S. Ferro 1,* 1 Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, Brazil;
[email protected] 2 Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianópolis 88040-900, Brazil;
[email protected] 3 Department of Cell and Developmental Biology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, Brazil;
[email protected] 4 Department of Physical Education, São Paulo State University (UNESP), Presidente Prudente 19060-900, Brazil;
[email protected] 5 Department of Pharmacology, National Institute of Pharmacology and Molecular Biology (INFAR), Federal University of São Paulo (UNIFESP), São Paulo 05508-000, Brazil;
[email protected] * Correspondence:
[email protected]; Tel.: +55-11-3091-7310 Received: 15 January 2020; Accepted: 25 February 2020; Published: 29 February 2020 Abstract: Overweight and obesity are among the most prominent health problems in the modern world, mostly because they are either associated with or increase the risk of other diseases such as type 2 diabetes, hypertension, and/or cancer. Most professional organizations define overweight and obesity according to individual body–mass index (BMI, weight in kilograms divided by height squared in meters). Overweight is defined as individuals with BMI from 25 to 29, and obesity as individuals with BMI 30. Obesity is the result of genetic, behavioral, environmental, physiological, ≥ social, and cultural factors that result in energy imbalance and promote excessive fat deposition.