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NEUROSCIENCE WINTER CONFERENCE 16th International Sölden Austria !April 8 -April 12 2014 Hotel Das Central !Final Scientific Program ! ! !Time schedule of keynote lectures and symposia !List of poster presentations !List of participants !Abstracts speakers !Abstracts posters !Program Commi*ee: !Contributors: !Exhibitors: - Abcam plc Tobias Bonhoeffer - Austrian Neuroscience AssociaBon ! Nils Brose - Das Central ! Alois Saria - Lundbeck Austria GmbH ! Stephan Schwarzacher ! ! ! ! - InternaBonal Society for ! Neurochemistry Organizer: brainplatform.net e.U. ! ! ! ! ! - Andor Technology Ltd. Conference Chair: - Tocris Bioscience !Alois Saria, Austria !- Novus Biologicals "1 ! ! ! ! Tuesday Wednesday Thursday April 8 April 9 Afternoon April 10 Morning ! ! ! !15:00 - 16:30 RegistraBon 13:20 - 15:20 Symposium 4 08:15 - 09:00 Keynote Lecture 2 16:30 - 17:00 Welcome Cocktail ! ! Glutamatergic transmission in schizophrenia Zach Mainen (Portugal) Neural circuits for 17:00 - 19:00 Symposium 1 Chair: Robert Schwarcz (USA) spontaneous acCon Cming in the frontal cortex ! ! Rapid cross-talk between synapBc receptors: A ChrisBne Konradi (USA) Hippocampal 09:00 - 11:00 Symposium 6 key path of synapBc plasBcity interneurons and mitochondrial abnormaliCes in ! 2+ Chair: Dmitri Rusakov (UK) psychoCc disorders Nanophysiology of presynapBc Ca signaling ! Joseph Coyle (USA) Serine racemase knockout Chair: Tobias Moser (Germany) Dmitri Rusakov (UK) A sub-millisecond mGluR- mice: A mouse model of NMDA receptor ! ++ NMDAR dialog triggering LTP hypofuncCon Erwin Neher (Germany) Ca -handling and Julie Perroy (France) Cross-talk between Robert Schwarcz (USA) The role of endogenous superpriming at the Calyx of Held glutamate receptors kynurenic acid in hippocampal funcCon and Jakob Neef (Germany) Number, topography and 2+ Antoine Triller (France) Control of synapCc dysfuncon coupling to release of Ca channels at hair cell strength by gypherin W. Wolfgang Fleischhacker (Austria) acCve zones 2+ Tobias Böckers (Germany) Ausc-like behaviours Glutamatergic agents in the management of the Tomoyuki Takahashi (Japan) Perimeter Ca TUESDAY TO THURSDAY AFTERNOON TO THURSDAY TUESDAY linked to the ProSAP/Shank funcCon symptoms of schizophrenia channel coupling to transmiXer release at ! developing calyces of Held ! ! Annalisa Scimemi (USA) Number and organizaCon ! of Ca2+ channels in the acCve zone of Schaffer ! ! collateral synapses Wednesday Wednesday Peter Jonas (Austria) Loose coupling between 2+ April 9 Morning April 9 Evening Ca channels and release sensors enables ! ! presynapCc plasCcity at a corCcal glutamatergic ! ! synapse 08:15 – 09:00 Keynote Lecture 1 16:00 – 18:00 Symposium 5 ! PROGRAM 2014 ! Herwig Baier (Germany) ReCnal ganglion cell Learning-related dynamics in neuronal circuits in 11:00 - 11:20 Coffee Break diversity creates separate visual processing vivo ! channels that are tailored to behavioral output Chairs: Sonja Hofer (Switzerland) and Mark ! ! Hübener (Germany) 11:20 - 13:20 Symposium 7 09:00 - 11:00 Symposium 2 ! ! Adi Mizrahi (Israel) Structural and funcConal ISN Symposium: Mitochondrial dysfuncBon in FuncBons of lyso-phosphaBdic acid (LPA) plasCcity of adult born neurons in the mouse Parkinson’s disease: Failure of protein quality signaling pathways in the CNS olfactory bulb control Chair: Robert Nitsch (Germany) Florian Engert (USA) Neural circuits underlying Chairs: Jörg Schulz (Germany) and Philipp Kahle ! operant learning in larval zebrafish (Germany) Orly Reiner (Israel) Novel acCviCes of autotaxin Tobias Rose (Germany) Neurons in visual cortex ! (ATX) in neuronal progenitors of the cerebral retain a memory of their inputs aVer monocular Richard J. Youle (USA) Role of PINK1 and Parkin on cortex deprivaon mitochondrial QC in vitro and in vivo Johannes Vogt (Germany) Control of early Sonja Hofer (Switzerland) Neural dynamics in Philipp Kahle (Germany) UBE2N, UBE2L3 and neuronal acCvity by synapCc phospholipids visual cortex during learning UBE2D2/3 ubiquiCn-conjugaCng enzymes are governs connecCvity and memory ! essenCal for parkin-dependent mitophagy Andrew J. Morris (USA) Role of lysophosphaCdic ! Konstanze Winklhofer (Germany) Parkin acid in traumaCc brain injury 18:00 - 18:20 Coffee Break maintains mitochondrial integrity via linear Robert Nitsch (Germany) Altered synapCc lipid ! ubiquiCnaCon of NEMO signaling affects corCcal informaCon processing ! Aaron Voigt (Germany) TRAP1, a new player involved in psychiatric disorders 18:20 - 19:05 Special Guest Lecture in Parkinson’s disease ! ! 11:00 - 11:20 Coffee Break Petra Schwille (Germany) Divide and conquer - 13:20 - 15:20 Symposium 8 ! syntheCc biology of cell division 11:20 - 13:20 Symposium 3 ! NeuroBioengineering: New strategies targeBng ! ! diverse neural cells for regeneraBve neurobiology MulBvariate and genome-wide approaches in 19:05 – 20:30 Poster Session Chairs: Philip Beart (Australia) and Eva Sykova imaging geneBcs ! (Czech Republic) Chair: Gunter Schumann (UK) ! ! ! Eva Sykova (Czech Republic) Stem cells and Jianfeng Feng (UK) Brain-wide associaCon study of ! biomaterials for treatment of CNS diseases resCng state acCvity idenCfies funcConal links ! Sarka Kubinova (Czech Republic) Advanced associated with psychiatric disorders methods for nervous Cssue engineering Jean-Luc MarBnot (France) Imaging brain ! Sue Barne* (UK) Can scaffold design affect CNS microstructure in mood disorders ! myelinaCon? Sylvane Desrivières (UK) TranscripConal control of ! Philip Beart (Australia) TherapeuCc potenCal of neural development: Impact on brain structure ! bioengineering strategies targeCng astrocytes and cogniCon ! ! Gunter Schumann (UK) Genome-wide methylaCon analysis of monozygoCc twins idenCfies ! associaCon of protein phosphatase, Mg2+/Mn2+ ! dependent, 1G (PPM1G) hypermethylaCon with alcohol use disorder and measures of ! impulsiveness ! "2 Thursday Friday Saturday April 10 Evening April 11 Morning April 12 Morning ! ! ! ! 16:00 – 18:00 Symposium 9 08:15 – 09:00 Keynote Lecture 3 08:15 – 09:00 Keynote Lecture 5 ! ! Ca2+ signaling and synapc transmission Christopher Harvey (USA) Neuronal circuit Ole Kiehn (Sweden) Neural circuits for controlling Chairs: Markus Missler (Germany) and MarBn dynamics during navigaCon-based decision tasks rhythmic movements Heine (Germany) ! ! ! 09:00 – 11:00 Symposium 11 09:00 – 09:30 Coffee Break Ralf Schneggenburger (Switzerland) Mechanisms ! ! of ultrafast transmiXer release at CNS synapses From circuits to behavior: Sensorimotor 09:30 – 11:30 Symposium 14 MarBn Heine (Germany) Calcium channel mobility interacBons in neural processing ! as a variable of synapCc transmission Chair: Georg Keller (Switzerland) Tracing neural processing hierarchies in auditory Gerald W. Zamponi (Canada) RegulaCon of ! funcon, from synapse to percepon calcium channels by ubiquiCnaCon Bence Ölveczky (USA) Motor cortex independent Chairs: Jan Schnupp (UK) and Yale Cohen (USA) Markus Missler (Germany) Calcium channels and skill execuon ! neurotransmiXer receptors as target molecules of Adam Kampff (Portugal) Moving with cortex: Benedikt Grothe (Germany) GABAergic THURSDAY EVENING TO SATURDAY EVENING TO SATURDAY THURSDAY α−neurexin-based complexes New techniques for studying behaviours that mechanisms underpin sub-millisecond precision in ! require motor cortex mammalian binaural hearing ! Dinu Albeanu (USA) Understanding the roles of Kasia Bieszczad (USA) A mnemonic funcon of 18:00 – 18:20 Coffee Break corCco-bulbar feedback in encoding odor idenCty primary auditory corCcal remodeling to predict the ! ! significance of sound ! 11:00 - 11:20 Coffee Break Jan Schnupp (UK) How the brain creates and 18:20 – 20:20 Symposium 10 ! encodes pitch and Cmbre percepts for complex ! ! sounds Coupling excocytoc neurotransmi*er release to 11:20 - 13:20 Symposium 12 Micah Murray (Switzerland) The speed of sound endocyc membrane retrieval ! in the human brain MulBple Sclerosis: New vistas PROGRAM 2014 Chair: Volker Haucke (Germany) ! ! Chair: Frauke Zipp (Germany) ! Stephan J. Sigrist (Germany) Shedding light on ! 11:30 End of meeBng and departure acCve zone structure and funcCon Ralf Gold (Germany) New therapies ! Jürgen Klingauf (Germany) Coupling of exo- and Bernhard Hemmer (Germany) New anCgens compensatory endocytosis Heinz Wiendl (Germany) New cellular pathways Ling-Gang Wu (USA) Post-fusion structural Frauke Zipp (Germany) Novel mechanisms and changes and their roles in exocytosis and targets in MulCple Sclerosis endocytosis ! Volker Haucke (Germany) Mechanisms of pre- ! synapCc membrane retrieval and synapCc vesicle ! reformaCon ! Friday ! April! 11 Evening ! ! ! !16:00 - 16:45 Keynote Lecture 4 ! Bill Hansson (Germany) Coding good and bad ! odors in the Drosophila olfactory system ! ! ! 16:45 – 17:05 Coffee Break ! ! ! !17:05 - 19:05 Symposium 13 ! Cellular trafficking in the brain ! !Chair: Ma*hijs Verhage (The Netherlands) ! Angus Silver (UK) Vesicle mobility and supply at a ! central excitatory synapse Ma*hias Kneussel (Germany) Transport and ! trafficking of neuronal proteins underlying synapCc ! plasCcity ! Frederic Saudou (France) HunCngCn: Linking ! energy supply to axonal transport and ! neurotrophin signaling Ma*hijs Verhage (The Netherlands) Trafficking ! and fusion of dense core vesicles in mammalian ! CNS neurons ! ! 19:30 Gala Dinner (free for Das Central hotel ! residents, others book at registraCon desk for 50,- ! € unl Thursday evening) "3 Wednesday ! ! April 9 ! ! 19:05 - 20:30 ! ! !Poster Session ! ! ! ! ! ! ! ! 1. Mitochondrial contribuBons to 10. Contrast normalizaon in cat