Amir Shmuel Montreal Neurological Institute, Mcgill University

Amir Shmuel, Ph.D

Curriculum Vitae (Short Version) Amir Shmuel Montreal Neurological Institute, McGill University

A. CONTACTS Office Address: MNI, 3801 University St., room NW109 Montreal H3A 2B4, QC, Canada Telephone (514) 398-2192 Fax (514) 398-8106 Email: [email protected]

B. EDUCATION 1999: Ph.D. in Neuroscience. Institution: The Weizmann Institute of Science, Rehovot, Israel. Fields of research: Vision, Cerebral Cortex, Organization of Visual Areas. Thesis: “Visual Areas V1 and V2: Functional Architecture and Organization of the Inter- Connectivity as Revealed by Optical Imaging”. Advisors: Prof. Amiram Grinvald and Prof. Shimon Ullman.

1990: M.Sc. in Computer Science. Institution: The Hebrew University of Jerusalem, Jerusalem, Israel. Fields of research: Computational Vision and Image Processing. Thesis: “Active Vision: 3D from an Image Sequence”. Advisors: Prof. Michael Werman and Prof. Shmuel Peleg. Graduated Summa Cum Laude.

1989: B.Med. in Medical Sciences. Institution: The Hebrew University of Jerusalem, Jerusalem, Israel.

1987: B.Sc. in Computer Science. Institution: The Hebrew University of Jerusalem, Jerusalem, Israel. Graduated Summa Cum Laude.

Amir Shmuel, Ph.D

Post-graduate training in research 2002 – 2007: Research Scientist and Senior Research Scientist in Neuroscience and Brain Imaging. Institution: Max-Planck Institute for Biological Cybernetics, Tuebingen, Germany. Department: Neurophysiology of cognitive processes. Fields of research: Mechanism of functional MRI signals and methods of imaging alert non-human primates. Advisor: Prof. Nikos K. Logothetis.

2003 – 2004: Long-term Fellow. Institution: European Molecular Biology Organization.

1999 – 2002: Postdoctoral Fellow in Brain Imaging. Institution: University of Minnesota, Minneapolis, MN, USA. Department: Radiology, Center for MR Research. Fields of research: Mechanism of functional MRI signals and high-resolution functional MRI of the visual cortex. Advisor: Prof. Kamil Ugurbil.

1999 – 1999: Postdoctoral Fellow in Neuroscience. Institution: The Weizmann Institute of Science, Rehovot, Israel. Department: Neurobiology. Fields of research: Vision, Cerebral Cortex, Organization of Visual Areas. Advisors: Prof. Amiram Grinvald and Prof. Shimon Ullman.

C. APPOINTMENTS University MNI, McConnell Brain Imaging Centre and Neuronal Circuits Unit McGill University, Montreal, QC, Canada 2015 – Co-Director, Quebec Platform for High-Field Brain Imaging 2012 – Canada Research Chair in Neuroscience and Brain Imaging (renewed) 2012 – MNI Killam Scholar 2012 – Associate Professor, Dept. of Neurology and Neurosurgery 2010 – Associate Member, Dept. of Physiology 2007 – Associate Member, Dept. of Biomedical Engineering 2013 – 2014 Interim director of MRI research 2007 – 2013 Assistant Professor, Dept. of Neurology and Neurosurgery 2007 – 2012 Canada Research Chair in Neuroscience and Brain Imaging

Center for MR Research, Dept. of Radiology University of Minnesota, Minneapolis, MN, USA 2004 – Visiting Scientist 2

Amir Shmuel, Ph.D

Other 1990 – 1992: Systems and Software Consultant to IMI Ltd., Israel

D. HONORS, AWARDS, RECOGNITION 1. Canada Research Chair award (2012 – 2017; tier II) 2. Human Brain Mapping Editor's Choice Award for 2008 Awarded for the paper: Shmuel A, Leopold DA (2008) Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: implications for functional connectivity at rest. Human Brain Mapping, 29:751-761. The award was presented at the opening ceremony of the 2009 meeting of the Organization for Human Brain Mapping. 3. Canada Research Chair award (2007 – 2012; tier II)

E. SELECTED GRANTS 1. Canada Foundation for Innovation (CFI) Program: Operating grant for operating the CFI-funded wide bore 7 Tesla scanner PI: Amir Shmuel Period: 2018/01 - 2022/12 Total funding: $2,254,900

2. MITACS Program: Elevate Using multivariate deep-learning algorithms for automatic quality control of high-resolution MRI PI: Amir Shmuel Period: 2017/02 - 2019/01 Total funding: $110,000

3. Canada Foundation for Innovation (CFI) Program: Innovation fund PI: Amir Shmuel Quebec Centre for High-Field Brain Imaging Period: 2016/04 - 2019/03 Total funding: $18,790,817

4. Canadian Institute for Brain Research (CIHR) Program: Operating grant PI: Edith Hamel The cellular basis of neurovascular coupling in the cerebral cortex Period: 2015/07 - 2020/06 Total funding: $772,095

Amir Shmuel, Ph.D

5. Natural Sciences and Engineering Council of Canada (NSERC) Program: Discovery grant PI: Amir Shmuel Mechanisms of high-resolution functional imaging and of decoding information conveyed by cortical columns Period: 2015/04 - 2019/03 Total funding: $285,000

6. Brain Canada Program: Platform operating grant PI: Amir Shmuel Montreal Primate Brain Imaging Period: 2014/12 - 2017/11 Total funding: $300,000

7. Canada Research Chairs Program: Canada Research Chairs PI: Amir Shmuel Period: 2012/06 - 2017/05 Total funding: $500,000

8. Natural Sciences and Engineering Council of Canada (NSERC) Program: CREATE PI: Kaleem Siddiqi CREATE Medical Image Analysis Period: 2012/04 - 2018/03 Total funding: $1,650,000

9. Canadian Institute for Brain Research (CIHR) Program: Operating grant PI: Amir Shmuel Neuronal Correlates of Spontaneous Fluctuations in Blood-Oxygenation Imaging Signals Period: 2010/04 - 2015/03 Total funding: $433,710

10. Natural Sciences and Engineering Council of Canada (NSERC) Program: Collaborative Health Research Program PI: Amir Shmuel Modeling and validating the effect of transcranial magnetic stimulation on cortical excitability Period: 2010/04 - 2013/03 Total funding: $1,650,000

11. Natural Sciences and Engineering Council of Canada (NSERC) Program: Discovery grant PI: Amir Shmuel Neurophysiological mechanisms of visual perception Period: 2009/04 - 2014/03 Total funding: $250,000 4

Amir Shmuel, Ph.D

12. Human Frontiers Science Program Program: Operating grant PI: Amir Shmuel Neuronal correlates of hemodynamic signals Period: 2008/08 - 2012/07 Total funding: $450,000

13. Canada Foundation for Innovation (CFI) Program: Infrastructure grant PI: Amir Shmuel Period: 20008/06 - 2010/05 Total funding: $640,000

14. Canada Research Chairs Program: Canada Research Chairs PI: Amir Shmuel Period: 2007/06 - 2012/05 Total funding: $500,000

F. SELECTED PUBLICATIONS Articles in peer reviewed journals (submitted or under revision) 1. *Yao Z-S, Fukuda M, Moon C-H, Kim S-G, Shmuel A (submitted) Cerebral blood volume functional MRI with no contributions from macroscopic vessels rules out the decoding of oriented grating stimuli through local irregularities in cat area 17. 2. *Chaimow D, Shmuel A (BioRxiv) A more accurate account of the effect of k-space sampling and signal decay on the effective spatial resolution in functional MRI. BioRxiv 097154, doi: https://doi.org/10.1101/097154. 3. *Chaimow D, Uğurbil K, Shmuel A (NeuroImage, minor revisions) Optimization of functional MRI for detection, decoding and high-resolution imaging of the response patterns of cortical columns. 4. *Chaimow D, Yacoub E, Uğurbil K, Shmuel A (NeuroImage, under revision) Spatial specificity of the functional MRI blood oxygenation response relative to neuronal activity. BioRxiv 097287, doi: https://doi.org/10.1101/097287. 5. *Yao Z-S, Villeneuve M, Kropf P, Peplowski A, Shmuel A (submitted) Spatial specificity of blood-oxygenation and blood volume responses of pial vessels and gray matter: implications for high-resolution fMRI. Articles in peer reviewed journals 6. *Lecrux C, Sandoe CH, *Neupane S, *Kropf P, Toussay X, Tong X-K, Shmuel A, Hamel E (2017) Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation. Journal of Neuroscience, 37(6):1518 –1531. 7. Tam A, Dansereau C, Badhwar A, Orban P, Belleville S, Chertkow H, Dagher A, Hanganu A, Monchi A, Rosa-Neto P, Shmuel A, Wang S, Breitner J, Bellec P, for the Alzheimer’s Disease

Amir Shmuel, Ph.D

Neuroimaging Initiative (2016) A dataset of multiresolution functional brain parcellations in an elderly population with no or mild cognitive impairment. Data in Brief, 9:1122-1129. 8. *Kropf P, Shmuel A (2016) 1-D current-source density (CSD) estimation in inverse theory: a unified framework for higher-order spectral regularization of quadrature and expansion type CSD methods. Neural Computation, 28:1305-1355. 9. *Dawson D, Lewis LB, *Carbonell F, Mendola JD, Shmuel A (2016) Partial-correlation based retinotopically organized resting-state functional connectivity within and between areas of the visual cortex reflects more than cortical distance. Brain Connectivity, 6(1):57-75. doi: 10.1089/brain.2014.0331. 10. Tam A, Dansereau C, Badhwar A, Orban P, Belleville S, Chertkow H, Dagher A, Hanganu A, Monchi O, Rosa-Neto P, Shmuel A, Wang S, Breitner J, Bellec P for the Alzheimer's Disease Neuroimaging Initiative (2015) Common Effects of Amnestic Mild Cognitive Impairment on Resting-State Connectivity Across Four Independent Studies. Front. Aging Neurosci. 7:242. doi: 10.3389/fnagi.2015.00242 11. *Sotero RC, Bortel A, *Na’aman S, *Mocanu MV, *Kropf P, *Villeneuve M, Shmuel A (2015) Laminar distribution of phase-amplitude coupling of spontaneous current sources and sinks. Front. Neurosci. 9:454. doi: 10.3389/fnins.2015.00454. 12. Buxton RB, Griffeth VE, Simon AB, Moradi F, Shmuel A (2014) Variability of the coupling of blood flow and oxygen metabolism responses in the brain: a problem for interpreting BOLD studies but potentially a new window on the underlying neural activity. Front Neurosci., 8:139. Corrigendum DOI: 10.3389/fnins.2014.00241. 13. Wu L, Soder RB, Schoemaker D, *Carbonnell F, Sziklase V, Rowley J, Mohades S, Fonov V, Bellec P, Dagher A, Shmuel A, Jiac JP, Gauthier S, Rosa-Neto P (2014) Resting state executive control network adaptations in amnestic mild cognitive impairment. Journal of Alzheimer’s disease, 40:993-1004. 14. *Carbonell F, Bellec P, Shmuel A (2014) Quantification of the impact of a confounding variable on functional connectivity confirms anti-correlated networks in the resting-state. Neuroimage, 86:343-53. 15. Rowley J, Fonov V, Wu O, Eskildsen SF, Schoemaker D, Wu L, Mohades S, Shin M, Sziklas V, Cheewakriengkrai L, Shmuel A, Dagher A, Gauthier S, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative (2013) White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and Alzheimer's disease. PLoS ONE, 8(9): e74776. doi:10.1371/journal.pone.0074776. 16. *Dawson D, *Cha K, Lewis LB, Mendola JD, Shmuel A (2013) Evaluation and calibration of functional network modeling methods based on known anatomical connections. Neuroimage, 67: 331–343. 17. Leontiev O, Buracas GT, Liang C, Ances BM, Perthen JE, Shmuel A, Buxton RB (2013) Coupling of cerebral blood flow and oxygen metabolism is conserved for chromatic and luminance stimuli in human visual cortex. Neuroimage, 68: 221–228. 18. *Sotero RC, Shmuel A (2012) Energy-based stochastic control of neural mass models suggests time-varying effective connectivity in the resting-state. Journal of Computational Neuroscience, 32 (3): 563-576 (doi: 10.1007/s10827-011-0370-8).

Amir Shmuel, Ph.D

19. *Carbonell F, Bellec P, Shmuel A (2011) Global and system-specific resting-state BOLD fluctuations are uncorrelated: principal component analysis reveals anti-correlated networks. Brain Connectivity, 1 (6): 496-510. 20. Zimmermann J, Goebel R, De Martino F, van de Moortele P-F, Feinberg D, Adriany G, *Chaimow D, Shmuel A, Uğurbil K, Yacoub E (2011) Mapping the organization of axis of motion selective features in human area MT using high-field fMRI. PLoS ONE 6(12): e28716. doi:10.1371/journal.pone.0028716. 21. *Leblond-Lecrux C, Toussay X, Kocharyan A, Fernandes P, *Neupane S, Lévesque M, Plaisier F, Shmuel A, Cauli B, Hamel E (2011) Pyramidal neurons are “neurogenic hubs” in the neurovascular coupling response to whisker stimulation. Journal of Neuroscience, 31: 9836- 9847. 22. *Chaimow D, Yacoub E, Ugurbil K, Shmuel A (2011) Modeling and analysis of mechanisms underlying fMRI-based decoding of information conveyed in cortical columns. Neuroimage, 56 (2): 627-642. 23. *Sotero RC, Bortel A, Martínez-Cancino R, *Neupane S, *O’Connor P, *Carbonell F, Shmuel A (2010) Anatomically-constrained effective connectivity among layers in a cortical column modeled and estimated from local field potentials. Journal of Integrative Neuroscience, 9: 355– 379. 24. Shmuel A, *Chaimow D, Raddatz G, Ugurbil K, Yacoub E (2010) Mechanisms underlying decoding at 7 T: Ocular dominance columns, broad structures, and macroscopic blood vessels in V1 convey information on the stimulated eye. Neuroimage, 49:1957–1964. 25. Shmuel A, Leopold DA (2008) Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: implications for functional connectivity at rest. Human Brain Mapping, 29:751-761. 26. Keliris G*, Shmuel A* (* co-first authors), Ku SP, Pfeuffer J, Oeltermann A, Steudel T, Ku SP, Logothetis NK (2007), Robust controlled functional MRI in alert monkeys at high magnetic field: effects of jaw and body movements. NeuroImage, 36(3):550-570. 27. Pfeuffer J, Shmuel A, Keliris G, Steudel T, Merkle H, Logothetis NK (2007) Functional MR imaging in the awake monkey: effects of motion on dynamic off-resonance and processing strategies. Magnetic Resonance Imaging, 25(6):869-882. 28. Yacoub E*, Shmuel A* (* co-first authors), Logothetis NK, Ugurbil K (2007), Robust detection of ocular dominance columns in humans using Hahn spin echo BOLD functional MRI at high field. NeuroImage, 37(4):1161–1177. 29. Shmuel A, Yacoub E, Chaimow D, Logothetis NK, Ugurbil K (2007), Spatio-temporal point- spread function of fMRI signal in human gray matter at 7 Tesla. NeuroImage, 35(2):539-552. 30. Shmuel A, Augath M, Oeltermann A, Logothetis NK (2006) Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1. Nature Neuroscience, 9(4):569-577. See also the news and views: Narain C (2006) Going down BOLDly. Nature Neuroscience, 9(4):474. 31. Yacoub E, Van De Moortele PF, Shmuel A, Ugurbil K (2005) Signal and noise characteristics of Hahn SE and GE BOLD fMRI at 7 T in humans. Neuroimage, 24(3):738-50. 7

Amir Shmuel, Ph.D

32. Shmuel A, Korman M, Melnik A, Harel M, Ullman S, Malach R, Grinvald A (2005) Retinotopic axis specificity and selective clustering of feedback projections from V2 to V1 in the owl monkey. The Journal of Neuroscience, 25(8):2117-31. 33. Swindale NV, Grinvald A, Shmuel A (2003) The spatial pattern of response magnitude and selectivity for orientation and direction in cat visual cortex. Cerebral Cortex, 13(3):225-238. 34. Shmuel A, Yacoub E, Pfeuffer J, Van De Moortele PF, Adriany G, Hu X, Ugurbil K (2002) Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain. Neuron, 36(6):1195-1210. See also the preview: Wade AR (2002) The negative BOLD signal unmasked. Neuron, 36(6):993- 995. 35. Pfeuffer J, Adriany G, Shmuel A, Yacoub E, Van De Moortele PF, Hu X, Ugurbil K (2002) Perfusion-based high-resolution functional imaging in the human brain at 7 T. Magnetic Resonance in Medicine, 47(5):903-911. 36. Pfeuffer J, Van De Moortele PF, Yacoub E, Shmuel A, Adriany G, Andersen P, Merkel H, Ugurbil K, Hu X (2002) Zoomed functional imaging in the human brain at 7 Tesla with simultaneous high spatial and high temporal resolution. Neuroimage, 17(1): 272-286. 37. Yacoub E, Shmuel A, Pfeuffer J, Van De Moortele PF, Adriany G, Ugurbil K, Hu X (2001) Investigation of the Initial Dip in fMRI at 7 Tesla. NMR in Biomedicine, 14(7-8):408-412. 38. Yacoub E, Shmuel A, Pfeuffer J, Van De Moortele PF, Adriany G, Andersen P, Vaughn JT, Merkle H, Ugurbil K, Hu X (2001) Imaging brain function in humans at 7 Tesla. Magnetic Resonance in Medicine 45(4):588-594. 39. Shmuel A, Grinvald A (2000) Coexistence of linear zones and pinwheels within orientation maps in cat visual cortex. Proceedings of the National Academy of Sciences USA 97(10):5568- 5573. 40. Shmuel A, Grinvald A (1996) Functional organization for direction of motion and its relationship to orientation maps in cat area 18. The Journal of Neuroscience, 16(21):6945-6964, and cover illustration.

Reviews and book chapters 1. Shmuel A, Maier A (2015) Neurophysiological basis of functional MRI. In: fMRI: From Nuclear Spins to Brain Function (editors, KÃ¢mil UÄŸurbil, KÃ¢mil UludaÄŸ and Lawrence J. Berliner). Biological Magnetic Resonance, Vol. 30. Springer Science and Business Media, New York, New York, USA. 2. Yacoub E, Shmuel A, Harel N (2015) High-resolution functional MRI. In: fMRI: From Nuclear Spins to Brain Function (editors, KÃ¢mil UÄŸurbil, KÃ¢mil UludaÄŸ and Lawrence J. Berliner). Biological Magnetic Resonance, Vol. 30. Springer Science and Business Media, New York, New York, USA. 3. Shmuel A (2010) Locally Measured Neuronal Correlates of functional MRI Signals. In: EEG- fMRI: Physiology, Technique and Applications (Mulert C, Lemieux L editors), Springer, Heidelberg, Germany. 4. Ugurbil K, Kim DS, Duong T, Hu X, Ogawa S, Gruetter R, Chen W, Kim SG, Zhu XH, Yacoub E, Van de Moortele PF, Shmuel A, Pfeuffer J, Merkle H, Andersen P, Adriany G (2001)

Amir Shmuel, Ph.D

Magnetic resonance imaging of brain function and neurochemistry. Proceedings of the IEEE 89(7):989-1140. 5. Grinvald A, Shmuel A, Glaser DE, Vanzetta I, Shtoyerman E, Shoham D, Arieli A (1999) Intrinsic signal imaging in the neocortex. In: Imaging of Neuronal Activity (Yuste R, Lanni F, Konnerth A editors), Cold Spring Harbor Laboratory Press. 6. Grinvald A, Shoham D, Shmuel A, Glaser DE, Vanzetta I, Shtoyerman E, Slovin H, Sterkin A, Wijnbergen C, Hildesheim R, Arieli A (1999) In-vivo optical imaging of cortical architecture and dynamics. In: Modern Techniques in Neuroscience Research (Windhorst U, Johansson H editors), pages 893-969, Springer, Berlin / Heidelberg, Germany.

G. INTERNATIONAL CONFERENCES: SYMPOSIA AND INVITED TALKS 1. Organized and chaired a symposium at the 22nd annual meeting of the Organization for Human Brain Mapping, Geneva, Switzerland, June 2016: Revealing Fine-Scale Representations and Processing with High-Resolution fMRI and MVPA

Participants: Elisha Merriam, New York University, New York, NY, United States. Amir Shumel, MNI, McGill University, Montreal, QC, Canada: “Evaluating contributions of fine- scale irregularities, low-frequency organizations, macroscopic blood vessels and spatiotemporal responses to fMRI-based orientation decoding”. Lars Muckli, University of Glasgow, Glasgow, United Kingdom. Nikolaus Kreigeskorte, MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom.

2. BRAIN: 27th International Symposium on Cerebral Blood Flow, Metabolism and Function, Vancouver, Canada, August 2015: “Lamina-specific mechanisms of spontaneous fluctuations in hemodynamic signals”.

3. 21st annual meeting of the Organization for Human Brain Mapping, Honolulu, United States, June 2015: “Neurophysiological mechanisms underlying fMRI-based evoked responses and resting-state functional connectivity”.

4. Organized and chaired a workshop at the 20th annual meeting of the Organization for Human Brain Mapping, Hamburg, Germany, June 2014: Biophysics, data-acquisition methods, and interpretation of laminar specific fMRI. Participants: Amir Shmuel, MNI, McGill University, Montreal, QC, Canada: “Inter-laminar functional connectivity and neurovascular coupling during spontaneous activity and evoked responses”. Essa Yacoub, Center for MR Research, University of MN, USA. Lars Muckly, University of Glasgow, UK.

5. 2nd Yale University’s Scientific Workshop on Brain Functional Organization, Connectivity and Behavior, Whistler, Canada, March 2014: “Neurophysiological mechanisms of resting-state functional connectivity”.

Amir Shmuel, Ph.D

6. ‘Advanced fMRI’ educational course at the 19th annual meeting of the Organization for Human Brain Mapping, Seattle, USA, June 2013: “The Physiology of fMRI and its Relation to Brain Information Processing”.

7. 10th European Congress on Epileptology, London, UK, September 2012: Session “EEG- fMRI in epilepsy”: “Neuronal correlates of fMRI signals”.

7. 3rd Biennial International Conference on Resting-State Brain Networks, Magdeburg, Germany, September 2012: “Neurophysiological and hemodynamic mechanisms associated with resting-state functional connectivity”.

8. Organized and chaired a workshop at the 18th annual meeting of the Organization for Human Brain Mapping, Beijing, China, June 2012: Attaining fMRI-Resolution on the Scale of Cortical Columns and Layers Participants: Kang Cheng, RIKEN Brain Science Institute, Wako, Saitama, Japan. Amir Shmuel, MNI, McGill University, Montreal, QC, Canada.. Jonathan R. Polimeni, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA.

9. Annual meeting of the International Society of Magnetic Resonance in Medicine, Melbourne, Australia, May 2012, educational course on ‘advanced fMRI’: “Neurophysiological basis of resting- state correlated functional MRI signals”.

10. 8th International Brain Research Organization world congress, Florence, Italy, July 2011: “Simultaneous spatiotemporal imaging of blood-oxygenation and neurophysiological signals”.

11. 2ed Biennial International Conference on Resting-State Brain Networks, Milwaukee, WI, USA, September 2010: “Mechanisms of spontaneous activity and resting-state functional connectivity”.

12. Organized and chaired a symposium at the 16th annual meeting of the Organization for Human Brain Mapping, Barcelona, Spain, June 2010: Decoding Information Conveyed by Cortical Columns: Mechanisms and Advanced Methods for Investigating Higher-Order Cognitive Functions Participants: Yukiasu Kamitani, Keihanna Science City, Japan. Federico Demartino, Maastricht University, Maastricht, The Netherlands. Amir Shmuel, MNI, McGill University, Montreal, QC, Canada; CMRR, University of Minnesota, USA. Frank Tong, Vanderbilt University, Nashville, TN, USA.

13. ‘Advanced fMRI’ educational course at the 16th annual meeting of the Organization for Human Brain Mapping, Barcelona, Spain, June 2010: “The neuronal and hemodynamic origins of fMRI signals and fMRI-based decoding”.

Amir Shmuel, Ph.D

14. 1st Biennial International Conference on Resting-State Brain Networks, Magdeburg, Germany, December 2008: “Spatial extent of correlation between spontaneous fluctuations in neurophysiological activity and fMRI signal in monkey V1”. 15. Annual meeting of the American society for Epilepsy, Seattle, USA, December 2008, Symposium on ‘Metabolic changes during epileptic discharges’ organized by Jean Gotman: “Relationship between neurophysiological activity, metabolism, and cerebral blood flow in the cerebral cortex”. 16. Xth International Conference on Cognitive Neuroscience, Bodrum, Turkey, September 2008, Symposium on ‘Multimodal Studies of Oscillations’ organized by Pedro Valdes-Sosa: “Neuronal correlates of spontaneous fluctuations in functional MRI signals”. 17. Organized and chaired a symposium at the 14th annual meeting of the Organization for Human Brain Mapping, Melbourne, Australia, June 2008: Neuronal correlates of spontaneous fluctuations in hemodynamic signals Participants: Michael Fox and Marcus Raichle, Washington University, St. Louis, MO, USA. Andreas Kleinschmidt, CEA, Paris, France. Amos Arieli, The Weizmann Institute of Science, Rehovot, Israel. Amir Shmuel, MNI, McGill University, Montreal, Canada. 18. Annual meeting of the International Society of Magnetic Resonance in Medicine, Berlin, Germany, May 2007, ‘Current Issues in Brain Function Study Group’ meeting: “Spontaneous fluctuations in functional MRI signals correlate with fluctuations in the underlying local neuronal activity”. 19. Annual meeting of the International Society of Magnetic Resonance in Medicine, Berlin, Germany, May 2007, Educational course on ‘fMRI: Basic to Cutting Edge’: “Relationship between fMRI signals and the underlying neurophysiological activity”. 20. Discussion leader, Gordon Research Conference on ‘Brain Energy Metabolism & Blood Flow’, organized by Marin Lauritzen and Edith Hamel, Oxford, UK, August 2006. 21. Organized and co-chaired a symposium at the 35th annual meeting of the Society for Neuroscience, Washington DC, USA, November 2005: Decreases in Cerebral Blood Flow and BOLD Signals: Neuronal Correlates and Mechanisms of Regulation. Participants: Marcus Raichle, Washington University St. Louis, MO, USA. Martin Lauritzen, Glostrup Hospital and University of Copenhagen, Denmark. Edith Hamel, Montreal Neurological Institute, McGill University, Montreal, Canada. Amir Shmuel, Max-Planck Institute for Biological Cybernetics, Tuebingen, Germany. 22. Organized and chaired a symposium at the 10th annual meeting of the Organization for Human Brain Mapping, Budapest, Hungary, June 2004: Decreases in Cerebral Blood Flow and BOLD Signals and their Neuronal Correlates. Participants: Marcus Raichle, Washington University St. Louis, MO, USA. Louis Lemieux, University College London, United Kingdom. Arno Villringer, Charite, Humboldt University, Berlin, Germany. Amir Shmuel, Max-Planck Institute for Biological Cybernetics, Tuebingen, Germany. 11

Amir Shmuel, Ph.D

H. SUPERVISION OF POSTDOCTORAL FELLOWS AND GRADUATE STUDENTS Alumni: Postdoctoral fellows 1. Felix Carbonell, Ph.D. Department: Neurology and Neurosurgery Research project: Modeling and analysis of fMRI-based functional connectivity in the resting- state Completed: 2010 Present Position: 'Biospective, Inc.', Montreal; R&D in the biomedical imaging high-tech sector

2. Clotilde Leblond-Lecrux, Ph.D. Department: Neurology and Neurosurgery Research project: Mechanisms of neurovascular coupling Completed: 2012 Present Position: Research Associate, Hamel's lab in collaboration with my lab

3. Martin Y Villeneuve, Ph.D. Department: Neurology and Neurosurgery Research project: Laminar-specific current-source density responses to oriented grating stimuli Completed: 2013 Present Position: Project manager, ‘Intelerad’, Montreal; R&D, R&D in the biomedical imaging high-tech sector

4. Roberto C Sotero, Ph.D. Department: Neurology and Neurosurgery Research project: Modeling and analysis of laminar-specific neurophysiological processes and neurovascular coupling Completed: 2014 Present Position: Tenure track Assistant Professor; University of Calgary

Alumni: Ph.D. students 5. ZeShan Yao, Ph.D. Program: Biomedical Engineering Research project: Mechanisms of decoding information conveyed by cortical columns Completed: 2016 Present Position: 'Synaptive Biomedical', Toronto; R&D in the biomedical imaging high-tech sector

6. Ajay Venkateswaran, Ph.D. Program: Biomedical Engineering Research project: Modeling and validating current density elicited by trans-cranial magnetic stimulation Completed: 2016 Present Position: R&D in the high-tech industry sector

Amir Shmuel, Ph.D

7. Pascal Kropf, Ph.D. Program: Biomedical Engineering Research project: Modeling and validating current density in the cerebral cortex Completed: 2016 Present Position: ‘Clemex Intelligent Microscopy‘, Montreal; R&D in the medical image analysis high-tech industry sector

Alumni: Master’s students 8. Mirza Baig, M.Eng. Program: Biomedical Engineering Research project: Design and implementation of a multi-purpose data acquisition and experiment control system for MRI and neuroscientific lab environments Completed: 2012 Present Position: ‘Cisco‘, Ottawa; R&D in the high-tech industry sector

9. Sujaya Neupane, M.Eng. Program: Biomedical Engineering Research project: Effects of repetitive Transcranial Magnetic stimulation on cortical activity Completed: 2011 Present Position: Ph.D. student, Integrated Program in Neuroscience

10. Sepide Movaghati, M.Eng. Program: Biomedical Engineering Research project: Spatiotemporal responses to natural images in the primary visual cortex Completed: 2015 Present Position: 'Synaptive Biomedical', Toronto; R&D in the biomedical imaging high-tech sector

11. Niladri Mohanty, M.Eng. Program: Biomedical Engineering Research project: Precise alignment of linear electrode probes to cortical layers Completed: 2015 Present Position: R&D in the high-tech industry sector

Postdoctoral fellows 1. Aleksandra Bortel, Ph.D. Department: Neurology and Neurosurgery Research project: Neurophysiological mechanisms underlying cortical seizures

2. Ricardo Pizarro, Ph.D. Department: Neurology and Neurosurgery Research project: Using multivariate deep-learning algorithms for analysis of MRI data

Amir Shmuel, Ph.D

Ph.D. students 3. Denis Chaimow Program: Center for MR Research, University of Minnesota; University of Tuebingen, Germany Research project: Modeling and analysis of high-resolution functional MRI of cortical Columns Status: Thesis submitted

4. Victor M Mocanu Program: Integrated Program in Neuroscience Research project: Laminar specific neurophysiological processes

5. Roland Pilgram Program: Integrated Program in Neuroscience Research project: Neurophysiological mechanisms of spontaneous fluctuations in functional MRI signals

6. Debra Dawson Program: M.D./Ph.D. program; Integrated Program in Neuroscience Research project: Evaluation of functional network modeling methods

7. Fadi Ayad Program: Biomedical Engineering Research project: Neurophysiological mechanisms of spontaneous fluctuations in functional MRI

8. Kelvin Mok Program: Biomedical Engineering Research project: MRI-based parcellation of the cerebral cortex

Master’s students 9. Sethu Boopathy Jegathambal Program: Center for MR Research, University of Minnesota Research project: MRI guided brain slicing for histology

I. EXTERNAL ORGANIZATIONS Member of professional societies Society for Neuroscience Organization for Human Brain Mapping International Society for Magnetic Resonance in Medicine International Brain Research Organization

Amir Shmuel, Ph.D

Organization of scientific meetings Chair of the organizing committee of the 2018 Resting-State Brain Connectivity conference

Editorial boards of scientific journal Frontiers in Brain Imaging Methods Associate editor Brain Connectivity Associate editor Frontiers in Integrative Neuroscience Member of the editorial board Frontiers in Neuroanatomy Member of the editorial board

Ad hoc reviewer for scientific journals Neuron Current Biology PNAS Cerebral Cortex Journal of Neuroscience\ Human Brain Mapping NeuroImage Experimental Neurology Trend in Cognitive Neuroscience PLOS One Journal of Vision Journal of Integrative Neuroscience Journal of Applied Physiology Journal of Neurophysiology Brain Topography Journal of Neuroscience Methods