WANNATE® IPDI Revision date: June 3, 2020 SAFETY DATA SHEET
Section 1: Identification
1.1 Product identifier: Wannate® IPDI
1.2 Recommended use: Identified uses: Material for a polyurethane system
Restrictions on use: Not for use in spray operations (e.g. spray painting). Industrial uses only, not intended for consumer and domestic (household) uses.
1.3 Supplier: Wanhua Chemical (America) Co., Ltd. 3803 West Chester Pike, Suite 240 Newtown Square, PA 19073 Customer service telephone: 610-566-5297 Telephone in Canada: 613-796-1606 www.whchem.com
1.4 Emergency telephone number: North America: Chemtrec 800-424-9300 (domestic) +1-703-527-3887 (international, collect calls accepted) Europe: +31 20 20 65132/65130 (08:30-17:30) +44 780 183 7343
Section 2: Hazard Identification
2.1 Classification: Acute toxicity (inhalation) Cat. 1; H330 Respiratory sensitization Cat. 1; H334 Skin irritation Cat. 2; H315 Skin sensitization Cat. 1; H317 Eye irritation Cat. 2A; H319 Specific Target Organ Toxicity, Single Exposure Cat. 3; H335
2.2 Label elements:
Danger Fatal if inhaled. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation. May cause respiratory irritation.
Prevention Do not breathe mists, spray, fume or vapors. Use only outdoors or in a well-ventilated area. In case of inadequate ventilation wear respiratory protection. Wash hands and exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves, protective clothing and eye protection or face protection.
Response IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER or doctor. IF ON SKIN: Wash with plenty of water. If skin irritation or rash occurs: Get medical attention. Take off contaminated clothing and wash it before reuse. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical attention.
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WANNATE® IPDI Revision date: June 3, 2020 SAFETY DATA SHEET
2.2 Label elements: Storage Store in a well-ventilated place. Keep container tightly closed. Store locked up.
Disposal Dispose of contents and container in accordance with local, regional, national and international regulations.
2.3 Other hazards: May be toxic to aquatic organisms with long lasting effects. Avoid releases to the environment. Collect spillage.
Section 3: Composition/Information on Ingredients
Chemical Name CAS No. Wt.% GHS Classification Acute tox. 1; H330 Isophorone diisocyanate (IPDI) Skin irrit. 2; H315 Eye irrit. 2A; H319 4098-71-9 99.5-100 [3-isocyanatomethyl-3,5,5-trimethylcyclohexyl Skin sens. 1; H317 isocyanate isophorone di-isocyanate] Resp. sens. 1; H334 STOT SE 3; H335
Section 4: First-Aid Measures
4.1 Description of first-aid measures: Inhalation: Take precautions to ensure your own safety before attempting rescue (e.g. wear appropriate protective equipment, use the buddy system).
Remove source of exposure or move person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER or doctor. If breathing has stopped, trained personnel should begin rescue breathing. Avoid mouth-to-mouth contact by using a barrier device.
Skin contact: Avoid direct contact. Wear chemical protective clothing, if necessary.
Take off immediately all contaminated clothing, shoes and leather goods (e.g. watchbands, belts). Rinse skin water lukewarm, gently flowing water or shower for several minutes. If skin irritation or rash occurs get medical attention. Wash contaminated clothing before re-use or discard.
Eye contact: Avoid direct contact. Wear chemical protective clothing, if necessary.
Remove source of exposure or move person to fresh air. Rinse eyes cautiously with lukewarm, gently flowing water for several minutes, while holding the eyelid(s) open. Remove contact lenses, if present and easy to do. Continue rinsing. Take care not to rinse contaminated water into the unaffected eye or onto the face. If irritation persists, get medical attention.
Ingestion: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER or doctor. If vomiting occurs naturally, have person lie on their side, in the recovery position.
4.2 Most important symptoms and effects, both acute and delayed: Inhalation: Symptoms of exposure to vapors from heating or spraying include bleeding nose, labored breathing, respiratory irritation, asthmatic reaction, coughing, sore throat and eye irritation. May cause pulmonary edema; effects may be delayed.
Skin contact: Irritating to skin. Symptoms include pain, redness, blisters, burning sensation. May cause burns. May cause an allergic skin reaction or rash; effects may be delayed.
Eye Contact: Causes serious eye irritation including burns. Symptoms include pain, redness, blurred vision, burning sensation. Damage may be permanent and may cause loss of vision.
Ingestion: Swallowing may causes severe irritation to the lips, mouth, throat and digestive tract. Symptoms of exposure include inflammation of tissues, ulceration and salivation.
4.3 Indication of any immediate medical attention and special treatment needed: If breathing difficulties develop, urgent medical treatment is necessary.
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WANNATE® IPDI Revision date: June 3, 2020 SAFETY DATA SHEET
Section 5: Fire-fighting Measures
5.1 Extinguishing media: Water fog or fine spray, alcohol-resistant foam, carbon dioxide or dry chemical (BC powder). Use water spray to cool fire-exposed containers. Exercise caution when using water since the reaction between water and hot isocyanates can be vigorous and will generate CO2 gas.
Unsuitable extinguishing media: High volume water jet.
5.2 Special hazards arising from the chemical: Product can burn if heated; Flash point ~155°C (311°F) During a fire, products of combustion may include toxic hydrogen cyanide, isocyanate vapor, carbon monoxide, carbon dioxide, nitrogen oxides, dense smoke and irritating or toxic fumes. Reacts vigorously with water at high temperatures. Closed containers may rupture violently when heated or contaminated with water.
5.3 Special protective equipment and precautions for firefighters: As for any fire, evacuate the area and fight the fire from a safe distance. Firefighters must wear full protective equipment including self-contained breathing apparatus with chemical protection clothing when firefighters are exposed to decomposition products from this material.
Section 6: Accidental Release Measures
6.1 Personal precautions, protective equipment and emergency procedures: Isolate the area; keep all unprotected people away from the spill area. Keep upwind to avoid inhalation of vapors. Wear respiratory protection. Wear protective gloves/protective clothing/eye protection/face protection (See Section 8). Do not breathe mists, spray, fumes or vapors. Ensure clean-up is conducted by trained personnel only. Ventilate the area. Extinguish or remove all ignition sources. Do not touch or walk through the spilled material. Spilled material may pose a slipping hazard. Stop the leak if you can do it without risk.
When cleaning with Decontamination solution, harmful gases may evolve; ensure adequate ventilation or wear a respirator.
6.2 Environmental precautions: Avoid releases to the environment and prevent material from entering confined areas, drains, domestic sewers, natural waterways, or storm water management systems.
6.3 Methods and material for containment and cleaning up: Immediately shut off the leak if it is safe to do so. Contain the spill with suitable non-combustible absorbent material (e.g. sand, silica gel, acid binder, universal binder). Use clean tools to collect absorbed material.
Shovel into open-top drums or plastic bags for further decontamination, if necessary. Do not seal drums or containers. Neutralize small spills with Decontamination solution. Never return spills in original containers for re-use.
Wash area with one of the following Decontamination solutions: Formulation A: Liquid surfactant 0.2% to 2%; Sodium carbonate 5% to 10%; Water to make up to 100%. Formulation B: Liquid surfactant 0.2% to 2%; Concentrated ammonia 3% to 8%; Water to make up to 100%. Formulation C: Ethanol, isopropanol or butanol 50%; Concentrated ammonia 5%; Water to make up to 100%.
Formulation B reacts faster than Formulation A. Formulation C is especially suitable for cleaning of equipment from unreacted isocyanate and neutralizing under freezing conditions.
6.4 Reference to other sections: See Section 8 for information on selection of personal protective equipment. See Section 13 for information on disposal of spilled product and contaminated absorbents.
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WANNATE® IPDI Revision date: June 3, 2020 SAFETY DATA SHEET
Section 7: Handling and Storage
7.1 Precautions for safe handling: Before handling, it is important that engineering controls are operating, protective equipment requirements and personal hygiene measures are being followed. People working with this chemical should be properly trained regarding its hazards and its safe use. Persons allergic to isocyanates, and particularly those suffering from asthma or other respiratory conditions, should not work with isocyanates. Keep container tightly closed. Do not breathe vapors, fumes, spray mist or dusts from this material. Use only in a well-ventilated area. Avoid contact with skin and eyes. Wear respiratory protection when handling heated product or if spraying. Wear protective gloves, protective clothing and eye/face protection. Contaminated work clothing must not be allowed out of the workplace. Do not reseal containers if contamination of containers is suspected. Assume that empty containers contain residues which are hazardous. Keep away from food and drink. Wash hands and exposed skin before eating, drinking or smoking and at the end of the workshift.
Refer to directives and regulations for instructions on the safe handling, employee training, monitoring and enforcement procedures for isocyanates [e.g. US Department of Labor, OSHA Directive # CPL 03-00-017 National Emphasis Program – Occupational Exposure to Isocyanates. Ontario Designated Substances Regulation-Isocyanates].
7.2 Conditions for safe storage: Store in a dry, well-ventilated area, out of direct sunlight and away from heat, sources of ignition and incompatible materials. Recommended storage temperature: 0 - 30°C (32 – 86°F). Have appropriate fire extinguishers and spill clean-up equipment in or near storage area. Store locked up in a place accessible by authorized persons only. Keep containers tightly closed. Store product in its original container. Incompatible with copper, and copper alloys, brass, bronze and zinc. Protect from moisture/humidity; Isocyanate may react with water producing CO2 gas, a hazardous build-up of pressure could result if contaminated containers are re-sealed. Do not re-seal contaminated containers.
Section 8: Exposure Controls / Personal Protection
8.1 Control parameters:
Occupational Exposure Limits: Consult local authorities for acceptable exposure limits.
Ingredient ACGIH® TLV® U.S. OSHA PEL Other Occupational Exposure Limits México VLE: 0.005 ppm
NIOSH REL: 0.005 ppm; 0.045 mg/m3 0.005 ppm 0.02 ppm; 0.180 mg/m3 STEL Isophorone diisocyanate 0.005 ppm 0.02 ppm STEL Ontario (Canada): 0.005 ppm 0.02 ppm Ceiling Designated Substance
8.2 Exposure controls: Exposure control measures: Handle product in closed system or area provided with appropriate exhaust ventilation. Handle in accordance with good industrial hygiene and safety practice. Ensure regular cleaning of equipment, work area and clothing. Curing ovens must be properly ventilated to prevent emissions of isocyanate into the workplace. Monitor the workplace air for the presence of isocyanate vapor and fume.
If engineering controls and work practices are not effective in controlling exposure to this material, then wear suitable personal protective equipment including approved respiratory protection. Have equipment available for use in emergencies such as spills or fire.
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WANNATE® IPDI Revision date: June 3, 2020 SAFETY DATA SHEET
8.3 Individual protection measures: Eye/Face protection: Wear chemical safety goggles. Wear a face-shield or full-face respirator when needed to prevent exposure to liquid, mist, vapor or fume.
Skin protection: Wear chemical protective gloves, suit, and boots to prevent skin exposure. Polyvinyl alcohol or Butyl rubber gloves may be used to minimize dermal exposures to this material and for cleaning and maintenance operations. Evaluate resistance under conditions of use and maintain protective clothing carefully. Where there may be high levels of airborne Isophorone diisocyanate the use of a chemical protective full body encapsulating suit and respiratory protection may be required.
Respiratory protection: Respiratory protection may be necessary when dusts are formed and if the product is heated to release fume or if a mist is created. If airborne dust, fume or mist exposure is likely wear an approved, particulate respirator or chemical cartridge respirator.
A respiratory protection program that meets the regulatory requirement, such as OSHA’s 29 CFR 1910.134 or Canadian Standards Association (CSA) Standard Z94.4, must be followed whenever workplace conditions warrant a respirator’s use.
NIOSH Respiratory Protection Guidelines for Isophorone diisocyanate : Up to 0.05 ppm: (APF = 10) Any supplied-air respirator. Up to 0.125 ppm: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode. Up to 0.25 ppm: (APF = 50) Any self-contained breathing apparatus with a full facepiece; or Any supplied-air respirator with a full facepiece. Up to 1 ppm: (APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode; or Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus. Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister; or any appropriate escape-type, self-contained breathing apparatus. Other protection: Safety shower, hand-wash station and eye-wash fountain readily available in the immediate work area.
Follow the applicable code for medical surveillance program indicated for isocyanates.
Environmental exposure controls: Store finished products in closed containers (e.g. bulk tanks, drums, cans). All waste products are assumed to be collected and returned for re-processing or incineration.
Section 9: Physical and Chemical Properties
9.1 Information on basic physical and chemical properties: Appearance: Liquid at normal room temperatures. Colorless and transparent. Odor: Pungent odor Odor threshold: 0.25 mg/m3 (perception limit) pH: Not applicable, reacts with water Melting point/freezing point: -60°C (-76 °F) Initial boiling point and boiling range: 158°C (316°F) Flash point: 155°C (311°F) Evaporation rate: Not available Flammability: Not flammable Upper/lower flammability or explosive limits: Not available Vapor pressure: 0.0009 hPa @ 20°C Vapor density: 7.67 (air = 1) Relative density: 1.062 @ 20°C (water = 1) Solubility (ies): 15 mg/L @ 23°C Partition coefficient (n-octanol/water): 2.03 @ 25°C Auto-ignition temperature: 430°C (806°F) Decomposition temperature: >260°C Viscosity: 1.05 – 1.06 mPa s (dynamic) @ 25 °C
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WANNATE® IPDI Revision date: June 3, 2020 SAFETY DATA SHEET
Section 10: Stability and Reactivity
10.1 Reactivity: Reacts with water, Amines, Strong bases, Alcohols, Metal compounds (e.g. organotin catalysts).
10.2 Chemical stability: Stable under prescribed conditions of use. Isocyanates are very reactive compounds and are especially highly reactive toward a large number of compounds with active hydrogens, particularly at high temperatures and in the presence of catalysts. May attack and make brittle many plastic and rubber materials.
10.3 Possibility of hazardous reactions: Heating above the flashpoint increases fire and explosion hazard. Isophorone diisocyanate may undergo uncontrolled exothermic polymerization upon contact with incompatible materials, especially strong bases, such as triethylamine and sodium hydroxide, trialkyl phosphines, potassium acetate, many metal compounds soluble in organic media, or if heated. The resulting pressure build-up could rupture closed containers.
10.4 Conditions to avoid: Avoid moisture, heat and freezing temperatures.
10.5 Incompatible materials: Strong bases, Amines, Alcohols, Acids - May react violently with generation of heat.
Metal compounds (e.g. organotin catalysts) - May polymerize with the generation of heat and pressure.
Amides, phenols, mercaptans, urethanes, ureas and surface active compounds (surfactants, non-ionic detergents) - May react vigorously or violently with the generation of heat.
Water - Reacts slowly, forming carbon dioxide which could rupture closed containers.
10.6 Hazardous decomposition products: Reaction of Isophorone diisocyanate and water forms toxic and corrosive Isophorone diamine. Thermal decomposition above 260°C may form highly toxic hydrogen cyanide and corrosive nitrogen oxides.
Section 11: Toxicological Information
11.1 Likely routes of exposure: Inhalation of aerosols or vapor. Skin contact. Eye contact. Ingestion.
11.2 Information on acute health effects: Inhalation: Substance has low volatility therefore inhalation is unlikely unless an aerosol mist is formed during spray operations. Toxic fumes may be generated at high temperatures. Acute toxicity data from animal studies demonstrated that respirable aerosols can be fatal if inhaled. Respirable aerosols caused pulmonary edema and severe respiratory tract irritation in animal tests.
Skin: Acute toxicity, dermal, tests in rats: sedation, ataxia and obvious skin irritation at the application site were observed in test animals.
Ingestion: Acute toxicity, oral, tests in rats: irritation of the stomach and intestinal mucosa was observed in test animals.
Skin corrosion / irritation Liquid IPDI causes serious skin irritation with inflammation, redness, rash swelling and blistering. Isocyanates can cause skin staining and hardening of the skin following repeated exposures.
Serious eye damage / irritation Liquid IPDI, aerosols or mist cause eye irritation. In humans, exposure to aerosols at 0.64 mg/m3, caused slight irritation and 1.37 mg/m3 caused severe eye irritation.
Acute Toxicity Data
Ingredient LD50 Oral LD50 Dermal LC50 Inhalation 4-hour Isophorone diisocyanate (IPDI) >4000 mg/kg (rat) >7000 mg/kg (rat) 0.031 mg/L (31 mg/m3 ) aerosol (rat)
STOT (Specific Target Organ Toxicity) – Single exposure Exposure to respirable aerosols caused severe respiratory tract irritation and pulmonary edema in animal tests.
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WANNATE® IPDI Revision date: June 3, 2020 SAFETY DATA SHEET
11.3 Information on delayed and chronic health effects: STOT (Specific Target Organ Toxicity) – Repeated exposure NOAEC Inhalation (rat) = 0.027 mg/m3in air ; 13 weeks, 5 days/week, 6 hours/day.
Aspiration hazard Data not available.
Sensitization - respiratory and/or skin Respiratory sensitizer in animal test with Guinea pig according to OECD test guideline 403. Guinea pig maximisation test: dermal sensitizing
Carcinogenicity Data not available. No ingredients of this product have been evaluated for carcinogenicity by the International Agency for Research on Cancer (IARC), the American Conference of Governmental Industrial Hygienists (ACGIH®) or the US National Toxicology Program (NTP).
Reproductive toxicity Development of offspring: NOAEL = 15 mg/kg bw/day in rats Fertility: NOAEL = 15 mg/kg bw/day in rats Effects on or via lactation: Data not available
Germ cell mutagenicity Negative for genetic toxicity in vitro according to OECD test guideline 476. Negative for genetic toxicity in vivo according to OECD test guideline 474.
Interactive effects Cross-sensitization between different diisocyanate substances may occur (respiratory and/or skin sensitization).
Section 12: Ecological Information
12.1 Toxicity: LC50 Freshwater fish (96-hour) >72mg/L Brachydanio rerio. EC50 Daphnia magna (48-hour) = 27 mg/L Daphnia magna. NOEC Freshwater algae (72-hour) = 4.4mg/L Desmodesmus subspicatus.
12.2 Persistence and degradability: Not readily biodegradable
12.3 Bioaccumulative potential: Not bioaccumulative
12.4 Mobility in soil: Log Koc= 4.562 (calculated)
Section 13: Disposal Considerations
13.1 Disposal methods: Do NOT discard into any sewers, on the ground or into any body of water. Store material for disposal as indicated in Section 7 Handling and Storage. Dispose of waste in accordance with relevant national, regional and local environmental control provisions.
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WANNATE® IPDI Revision date: June 3, 2020 SAFETY DATA SHEET
Section 14: Transport Information
14.1 UN number: UN2290
14.2 Shipping name: ISOPHORONE DIISOCYANATE
14.3 Transport hazard class(es): Class 6.1
14.4 Packing group: III
14.5 Environmental hazards: Aquatic Chronic Cat. 2: Toxic to aquatic life with long lasting effects. Hazardous substance RQ Methylene Isophorone Diisocyanate 500 lb (227 kg)
14.6 Special precautions for user: ERG 156
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code: Not available
Section 15: Regulatory Information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture: USA TSCA Status: Substances are listed on the TSCA inventory.
SARA Title III : Sec. 313 Isophorone diisocyanate 1% de minimis CERCLA RQ Isophorone diisocyanate 500 lbs (227kg)
Canada NSNR Status: Substance is listed on the on the DSL.
NPRI: Isophorone diisocyanate; Part I, Group A Substance
International Inventories: Australia: Substance listed on the Inventory of Chemical Substances (AICS).
China: Substance present on the Chemical Inventory (IECSC).
European Union: Substance listed on EINECS.
Japan: Substance present on the inventory Existing and New Chemical Substances (ENCS).
Korea: Substance present on the inventory - Existing and Evaluated Chemical Substances.
Mexico: Substance present on the Chemical Inventory (INSQ).
New Zealand: Substance present on the Chemical Inventory (NZIoC).
Philippines: Substance present on the Inventory of Chemicals and Chemical Substances (PICCS).
Taiwan: Substance present on the Chemical Substance Inventory (TCSI).
Turkey: Substance present on the Chemical Inventory.
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WANNATE® IPDI Revision date: June 3, 2020 SAFETY DATA SHEET
Section 16: Other Information
Revision date: June 3, 2020 Revision summary: Previous version January 28, 2019 Revisions since previous version: Section 2.1, Eye irritation Cat. 2A
References and sources for data: RTECS, Registry of Toxic Effects of Chemical Substances NIOSH Pocket Guide
Legend to abbreviations: ACGIH – American Conference of Governmental Industrial Hygienists AIHA – American Industrial Hygiene Association GHS- Globally Harmonized System for Classification and Labeling. IDLH – Immediately Dangerous to Life or Health LD50- Median lethal dose; the dose causing 50 % lethality LOAEL-Lowest observed adverse effect level NIOSH-National Institute for Occupational Safety and Health NOEC- No observed effect concentration OEL– Occupational exposure limit OSHA - Occupational Safety and Health Administration TLV - Threshold Limit Value WHMIS – Workplace Hazardous Materials Information System.
Supplier Note: This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be construed as guaranteeing any specific property of the product.
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