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Annual Report 2009 Annual Report 2009 National Perinatal Epidemiology Unit Annual Report 2009 Front Cover This six week old Ghanian baby was born to a mother participating in the international CORONIS Trial of caesarean section surgical techniques. The trial is co-ordinated by the NPEU Clinical Trials Unit. For more information about CORONIS see: www.npeu.ox.ac.uk/coronis Citation for this report: National Perinatal Epidemiology Unit, Annual Report 2009. Oxford: NPEU, 2010 © National Perinatal Epidemiology Unit 2010 ISSN 1757-5907 Produced by: Lynne Roberts and Jenny Kurinczuk Design and layout by: Andy Kirk Cover design by: Sarah Chamberlain Printed by: The Holywell Press Ltd Contents Introduction ................................................................................................. 1 Contact Details ............................................................................................. 2 NPEU Staff ................................................................................................... 3 Website ....................................................................................................... 4 Programme of Work ...................................................................................... 5 Introduction ......................................................................................... 5 Programme of Work – Ongoing Studies .................................................... 6 Programme of Work – Studies Completed in 2008-09 ............................... 11 Projects started in 2009 ....................................................................... 14 Stream 1: The compromised fetus and baby .................................... 14 Stream 2: Care of the healthy woman and baby ............................... 21 Stream 3: Maternal morbidity ........................................................ 24 Publications 2008 – 2010............................................................................. 29 NPEU Advisory Committee 2009 ................................................................... 39 Sources of funding ...................................................................................... 41 Introduction Welcome to the 2009 Annual Report from through national studies of “near miss” the National Perinatal Epidemiology Unit. maternal morbidity This programme of This year has been another good year research (called UKNeS) will run from for the NPEU with a number of important January 2010 until the end of December publications, new grants and continued 2014. growth of the Unit. A number of health economic papers One of the highlights of 2009 was the were also published in 2009, including publication of the results of the TOBY Trial economic evaluations alongside clinical in the New England Journal of Medicine. trials, methodological papers and papers The TOBY Trial was a randomised which discuss approaches to valuing controlled trial of whole body cooling for health utilities in children, which remains a babies born with evidence of moderate challenging issue with respect to economic or severe encephalopathy. The trial evaluations of childhood diseases and demonstrated benefit of cooling for treatments. these babies in terms of their disability- free survival up to the age of eighteen As always, if you have any questions about months. When the results from TOBY any of the planned or on-going topics in were combined with the results of existing our work programme, please get in touch randomised controlled trials (published with either myself or the contact person. in the BMJ), it is clear that whole body hypothermia is an effective intervention in this group of babies and for the first time neonatologists have something helpful to offer this group of severely ill babies. What has also been gratifying is that the MRC, who funded the trial, have agreed to fund a follow-up study of babies born in the TOBY Trial who have survived to the age of 5-7 years. Follow-up is very important following interventions in the perinatal period because short-term outcomes may not predict long-term outcomes. We look forward to starting this important follow- up project in 2010. We have also conducted focused work on alcohol drinking in pregnancy with four publications of analyses trying to find a link between low or moderate alcohol use in pregnancy and adverse outcomes for the children. We found none. Other notable publications from the Unit in 2009 include a number of new papers arising from the UK Obstetric Surveillance System (UKOSS). These includes the reports of studies on TB in pregnancy in the UK, an analysis of ethnic variations in severe morbidity looking across of range of the conditions studies in UKOSS to date, and the Annual Report, which contains a summary of all the on-going and planned studies. Marian Knight, who runs UKOSS, NPEU Director: was also awarded a NIHR Programme Professor Peter Brocklehurst Grant entitled Beyond maternal mortality: improving the quality of maternity care NPEU Annual Report 2009 1 Contact Details Telephone numbers: General. + 44 (0) 1865 289700 Peter Brocklehurst (Director) . + 44 (0) 1865 289719 Lynne Roberts (PA to the Director) . + 44 (0) 1865 289719 Jenny Kurinczuk (Deputy Director) . + 44 (0) 1865 289717 Sue Bellenger (Administrator) . + 44 (0) 1865 289706 Karen Lindsay (Deputy Administrator - Personnel). + 44 (0) 1865 289705 Luke Blount (Deputy Administrator - Grants). + 44 (0) 1865 617933 Fax numbers: General. + 44 (0) 1865 289701 Confidential. + 44 (0) 1865 289720 Address National Perinatal Epidemiology Unit University of Oxford For individual staff contact details Old Road Campus and email addresses, please go to: Headington www.npeu.ox.ac.uk/staff Oxford OX3 7LF 2 NPEU Annual Report 2009 NPEU Staff Missing Tricia Boyd Claire Carson Sarah Chamberlain Sara Edwards Kate Fitzpatrick Edward Gosden 19 21 23 25 27 29 40 42 44 46 Ron Gray 6 7 8 9 10 20 22 24 26 28 39 41 43 45 47 Pollyanna Hardy 54 55 56 57 58 59 Denise Jennings Ed Juszczak Gwyneth Lewis Lynn Lynch Dominika Misztela Marta Nowicki Laura Oakley Stavros Petrou Maria Quigley Shan Rich 1 2 3 4 5 11 12 13 14 15 16 17 18 30 32 34 36 38 48 49 50 51 52 53 Dimitrios Rovithis 31 33 35 37 Lizzy Schroeder Rui Zhao 1. Clare Shakeshaft 16. Shannon Armstrong 30. Catherine Rounding 45. Jennifer Hollowell 2. Ann Kennedy 17. Karen Lindsay 31. Sarah Lawson 46. Helen Davenport 3. Clara Bowyer 18. Angela Garrett 32. Stella Khenia 47. Anna Hobson 4. Lydia Saroglou 19. Geraldine Surman 33. Jenny Kurinczuk 48. Nishma Patel 5. Rachel Roberts 20. Katriina Heikkila 34. Brenda Strohm 49. Katie Lean 6. David Puddicombe 21. Bob Gatten 35. Kayleigh Morgan 50. Louise Linsell 7. Lyn Pilcher 22. Jane Forrester- 36. Barbara Farrell 51. Amy Crane 8. Peter Brocklehurst Barker 37. Sophie Wragg 52. Madalena Gallagher 9. Suzanne Williams 23. Gry Poulsen 38. Alex Bellenger 53. Lynne Roberts 10. Vicki Barber 24. Anne Smith 39. Sue Bellenger 54. Mary Logan 11. Mara Violato 25. Helen Newdick 40. Paul Heal 55. Pauline Rushby 12. Nina Armstrong 26. Åse Silvertson 41. Gilles Kayem 56. Jenny Bulstrode 13. Carole Harris 27. Andy King 42. Mary Stewart 57. Luke Blount 14. Rachel Rowe 28. Andy Kirk 43. Ursula Bowler 58. Maggie Redshaw 15. Patsy Spark 29. Marian Knight 44. Matthias Pierce 59. Oya Eddama NPEU Annual Report 2009 3 Website www.npeu.ox.ac.uk The website continues to grow ever more • The top three most popular pdf’s popular with tens of thousands of requests downloaded are: each month. Behind the scenes the website 1. Recorded delivery: a national survey continues to be developed, improving the of women’s experience of maternity experience for all our visitors. care 2006: www.npeu.ox.ac.uk/recorded- Website Statistics delivery • The website currently still receives 2. Review of the Fetal Effects of a steady average of over 1000 page Prenatal Alcohol Exposure: requests per day. www.npeu.ox.ac.uk/downloads/ • Currently, the top 3 most frequently reports/alcohol-report.pdf visited areas of the website, in order, are: 3. UKOSS Annual Report 2009 1. Jobs: www.npeu.ox.ac.uk/ukoss/annual- www.npeu.ox.ac.uk/jobs reports 2. UKOSS: • The top three most popular search terms www.npeu.ox.ac.uk/ukoss which lead people to our site are: 3. TOBY: 1. “npeu” www.npeu.ox.ac.uk/toby 2. “ukoss” 3. “toby trial” The homepage for the INFANT trial 4 NPEU Annual Report 2009 Programme of Work Introduction The NPEU programme of work for the following two tables which separate work period 2008 to 2010 is described in this in progress, listed in the first table, from section of the report. The programme completed studies which are given in the of work is conceptualised and illustrated second table. Following the summary above using the framework of four streams tables and to avoid the repetition from of work with two cross-cutting themes and year to year we have included the full the rods denoting the different research details of only new projects which started methodologies used. A summary of all in 2009. These are described after the the work in progress and work completed summary table under the headings of the during 2008 and 2009 is given in the four streams of work. NPEU Annual Report 2009 5 Programme of Work – Ongoing Studies NPEU Table of Work Key NPEU contact: Most projects involve an NPEU team and often outside collaborators. The postscript (a) means that the grant holder or chief investigator for the project is from outside the NPEU. The initials of the NPEU researchers are used in the table for brevity and represent the chief investigator or
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