Product Datasheet

Human CRLF2,TSLP R ELISA Kit

Catalog No: #EK5577

Orders: [email protected] Description Support: [email protected]

Product Name Human CRLF2,TSLP R ELISA Kit

Specificity Human

Crossing Reactivity There is no detectable cross-reactivity with other relevant .

Immunogen Type NSO,G25-K231

Other Names receptor-like factor 2; -like 2; IL-XR; Thymic stromal lymphopoietin receptor;

TSLP receptor; CRLF2; CRL2, ILXR, TSLPR;

Accession No. Q9HC73

Cell Localization Isoform 1: Cell membrane; Single-pass type I membrane protein.

Application Details

sensitivity:10pg mlDetect Range:156pg ml-10 000pg mlsample_type:cell culture supernates cell lysates tissue homogenates serum and plasma (heparin

EDTA).capture_antibody:monoclonal from mousedetection_antibody:polyclonal antibody from goatgene_name:CRLF2protein_name:Cytokine

receptor-like factor 2gene_full_name:Cytokine receptor-like factor 2tissue_specificity: Expressed in heart skeletal muscle kidneyand adult and fetal liver.

Primarily expressed in dendrites andmonocytes. Weakly expressed in T-cells.sequence_similarities:Belongs to the family. Type 5

subfamily. tmb_incubation:20-25minresearch_category:immunology|innate immunity|

Product Description

Sandwich High Sensitivity ELISA for Quantitative Detection of Human CRLF2,TSLP R

Background

protein_function: Receptor for thymic stromal lymphopoietin (TSLP). Formsa functional complex with TSLP and IL7R which is capable ofstimulating cell proliferation through activation of STAT3 andSTAT5. Also activates JAK2 (By similarity). Implicated in thedevelopment of the hematopoietic system..Cytokine receptor-like factor 2, also known as TSLPR or CRL2, is a protein that in humans is encoded by the CRLF2 . It is mapped to Xp22.33. The protein encoded by this gene is a receptor for thymic stromal lymphopoietin(TSLP). Together with the 7 receptor(IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. In addition to it, it has been found that rearrangement of CRLF2 and JAK mutation together contribute to leukemogenesis in B-progenitor ALL.

Note: This product is for in vitro research use only and is not intended for use in humans or animals.

Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 1