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Advances in the Pathogenesis and Possible Treatments for Multiple Hereditary Exostoses from the 2016 International MHE Conference
Connective Tissue Research ISSN: 0300-8207 (Print) 1607-8438 (Online) Journal homepage: https://www.tandfonline.com/loi/icts20 Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference Anne Q. Phan, Maurizio Pacifici & Jeffrey D. Esko To cite this article: Anne Q. Phan, Maurizio Pacifici & Jeffrey D. Esko (2018) Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference, Connective Tissue Research, 59:1, 85-98, DOI: 10.1080/03008207.2017.1394295 To link to this article: https://doi.org/10.1080/03008207.2017.1394295 Published online: 03 Nov 2017. Submit your article to this journal Article views: 323 View related articles View Crossmark data Citing articles: 1 View citing articles Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=icts20 CONNECTIVE TISSUE RESEARCH 2018, VOL. 59, NO. 1, 85–98 https://doi.org/10.1080/03008207.2017.1394295 PROCEEDINGS Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference Anne Q. Phana, Maurizio Pacificib, and Jeffrey D. Eskoa aDepartment of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA; bTranslational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA ABSTRACT KEYWORDS Multiple hereditary exostoses (MHE) is an autosomal dominant disorder that affects about 1 in 50,000 Multiple hereditary children worldwide. MHE, also known as hereditary multiple exostoses (HME) or multiple osteochon- exostoses; multiple dromas (MO), is characterized by cartilage-capped outgrowths called osteochondromas that develop osteochondromas; EXT1; adjacent to the growth plates of skeletal elements in young patients. -
Post-Traumatic Osteolysis of the Clavicle: a Case Report C
Arch Emerg Med: first published as 10.1136/emj.3.2.129 on 1 June 1986. Downloaded from Archives of Emergency Medicine, 1986, 3, 129-132 Post-traumatic osteolysis of the clavicle: a case report C. J. GRIFFITHS AND E. GLUCKSMAN Department ofAccident and Emergency Medicine, King's College Hospital, Denmark Hill, London, England SUMMARY A case of post-traumatic osteolysis of the clavicle occurring in a 25-year-old male is described. The condition should be suspected in anyone giving a history of persistent shoulder pain following trauma or intensive sporting activities. Characteristic resorp- tion of the distal tip of the clavicle is found on X-ray. The condition usually responds by copyright. within 2 years to conservative treatment. Previous reports ofthe condition are reviewed, and the possible pathogenesis and differential diagnosis discussed. INTRODUCTION Post-traumatic osteolysis of the clavicle is an uncommon condition characterized by http://emj.bmj.com/ persistent shoulder pain associated with decalcification of the distal tip of the clavicle following trauma to the acromio-clavicular joint (Madsen, 1963; Smart, 1972; Quinn & Glass, 1983). Patients usually give a history of previous trauma to the shoulder, but the condition may follow active sports such as weight training (Cahill, 1982) or the use of pneumatic tools (Ehricht, 1959). The condition usually resolves within 2 years in the absence of further trauma. This article describes a case of post-traumatic osteolysis of on September 28, 2021 by guest. Protected the clavicle, and discusses the diagnosis and possible pathogenesis of the condition. CASE REPORT A 25-year-old medical student (C.G.) was involved in a bicycle accident and received a direct blow to his right shoulder. -
Immunopathologic Studies in Relapsing Polychondritis
Immunopathologic Studies in Relapsing Polychondritis Jerome H. Herman, Marie V. Dennis J Clin Invest. 1973;52(3):549-558. https://doi.org/10.1172/JCI107215. Research Article Serial studies have been performed on three patients with relapsing polychondritis in an attempt to define a potential immunopathologic role for degradation constituents of cartilage in the causation and/or perpetuation of the inflammation observed. Crude proteoglycan preparations derived by disruptive and differential centrifugation techniques from human costal cartilage, intact chondrocytes grown as monolayers, their homogenates and products of synthesis provided antigenic material for investigation. Circulating antibody to such antigens could not be detected by immunodiffusion, hemagglutination, immunofluorescence or complement mediated chondrocyte cytotoxicity as assessed by 51Cr release. Similarly, radiolabeled incorporation studies attempting to detect de novo synthesis of such antibody by circulating peripheral blood lymphocytes as assessed by radioimmunodiffusion, immune absorption to neuraminidase treated and untreated chondrocytes and immune coprecipitation were negative. Delayed hypersensitivity to cartilage constituents was studied by peripheral lymphocyte transformation employing [3H]thymidine incorporation and the release of macrophage aggregation factor. Positive results were obtained which correlated with periods of overt disease activity. Similar results were observed in patients with classical rheumatoid arthritis manifesting destructive articular changes. This study suggests that cartilage antigenic components may facilitate perpetuation of cartilage inflammation by cellular immune mechanisms. Find the latest version: https://jci.me/107215/pdf Immunopathologic Studies in Relapsing Polychondritis JERoME H. HERmAN and MARIE V. DENNIS From the Division of Immunology, Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45229 A B S T R A C T Serial studies have been performed on as hematologic and serologic disturbances. -
Management of the 'Young' Patient with Hip Disease
ARTHROPLASTY OF THE LOWER EXTREMITIES Management of the ‘Young’ Patient with Hip Disease SCOTT A. RITTERMAN, MD; LEE E. RUBIN, MD ABSTRACT abnormalities lead to impingement within the joint, altered Although hip arthritis typically affects older patients, biomechanics and ultimately cartilage loss.2 Secondary there is a rapidly growing population of “young” patients osteoarthritis can be due to an identifiable cause such as experiencing debilitating symptoms from hip disease. trauma to the femoral head, post-infection arthritis, slipped Most commonly, osteoarthritis and avascular necrosis af- capital femoral epiphysis, or hip dysplasia. fect this population, but a variety of other primary struc- As we age, the water content of cartilage increases with tural and metabolic causes can also occur. The expecta- a concomitant decrease in protein content, both leading to tions of these younger patients are often distinct from degeneration. The progressive loss of the cartilage matrix geriatric patients, and the challenges in optimizing their leads to recurrent bouts of inflammation as bone contacts care are unique in this demanding population. Selection bone, and reactive bone called osteophyte forms around the of the implant, bearing surface, and surgical technique joint. In the subchondral bone, hardening and cyst formation can all impact the success and longevity of total hip re- occurs. Repeated bouts of inflammation also extend into the placement. A consideration for respecting the native peri-articular soft tissues leading to deformity and contrac- bone stock is an important consideration that can poten- tures of the capsule, supporting ligaments, and tendons. Put tially reduce some of the future challenges of revision ar- together, these changes lead to pain, stiffness, and gait dis- throplasty in this young population. -
Pathological Fracture of the Tibia As a First Sign Of
ANTICANCER RESEARCH 41 : 3083-3089 (2021) doi:10.21873/anticanres.15092 Pathological Fracture of the Tibia as a First Sign of Hyperparathyroidism – A Case Report and Systematic Review of the Current Literature ALEXANDER KEILER 1, DIETMAR DAMMERER 1, MICHAEL LIEBENSTEINER 1, KATJA SCHMITZ 2, PETER KAISER 1 and ALEXANDER WURM 1 1Department of Orthopaedics and Traumatology, Medical University of Innsbruck, Innsbruck, Austria; 2Institute for Pathology, INNPATH GmbH, Innsbruck, Austria Abstract. Background/Aim: Pathological fractures are rare, of the distal clavicles, a “salt and pepper” appearance of the suspicious and in some cases mentioned as the first sign of a skull, bone cysts, and brown tumors of the bones (3). malignant tumor. We present an uncommon case with a Primary hyperparathyroidism (PHPT), also known as “brown pathological fracture of the tibia diaphysis as the first sign of tumor”, also involves unifocal or multifocal bone lesions, which severe hyperparathyroidism. Case Report: We report the case represent a terminal stage of hyperparathyroidism-dependent of a female patient who was referred to the emergency bone pathology (4). This focal lesion is not a real neoplasm. In department with a history of progressively worsening pain in localized regions where bone loss is particularly rapid, the lower left leg and an inability to fully bear weight. No hemorrhage, reparative granulation tissue, and active, vascular, history of trauma or any other injury was reported. An x-ray proliferating fibrous tissue may replace the healthy marrow revealed an extensive osteolytic lesion in the tibial shaft with contents, resulting in a brown tumor. cortical bone destruction. Conclusion: Our case, together with Histologically, the tumor shows bland spindle cell very few cases described in the current literature, emphasizes proliferation with multinucleated osteoclastic giant cells and that in the presence of hypercalcemia and lytic lesions primary signs of bone resorption. -
Information to Users
INFORMATION TO USERS This manuscript has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter free, i ^ e others may be from any type of computer printer. The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely afreet reproduction. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book. Photographs included in the original manuscript have been reproduced xerographically in this copy. Higher quality 6” x 9” black and white photographic prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order. UMI A Bell & Howell Information Compaiy 300 North Zeeb Road, Ann Arbor MI 48106-1346 USA 313/761-4700 800/521-0600 PHYSIOLOGIC RESPONSES TO INFLAMMATION IN ISOLATED EQUINE JOINTS DISSERTATION Presented in Partial Fulfilment of the Requirements for the Degree of Doctor of Philosophy in the Graduate School of The Ohio State University B y Joanne Hardy, D.V.M., M.S. -
1019 2 Feb 11 Weisbrode FINAL.Pages
The Armed Forces Institute of Pathology Department of Veterinary Pathology Wednesday Slide Conference 2010-2011 Conference 19 2 February 2011 Conference Moderator: Steven E. Weisbrode, DVM, PhD, Diplomate ACVP CASE I: 2173 (AFIP 2790938). Signalment: 3.5-month-old, male intact, Chow-Rottweiler cross, canine (Canis familiaris). History: This 3.5-month-old male Chow-Rottweiler mixed breed dog was presented to a veterinary clinic with severe neck pain. No cervical vertebral lesions were seen radiographically. The dog responded to symptomatic treatment. A week later the dog again presented with neck pain and sternal recumbency. The nose was swollen, and the submandibular and popliteal lymph nodes were moderately enlarged. The body temperature was normal. A complete blood count (CBC) revealed a marked lymphocytosis (23,800 lymphocytes/uI). Over a 3-4 hour period there was a noticeable increase in the size of all peripheral lymph nodes. Treatment included systemic antibiotics and corticosteroids. The dog became ataxic and developed partial paralysis. The neurologic signs waxed and waned over a period of 7 days, and the lymphadenopathy persisted. The peripheral blood lymphocyte count 5 days after the first CBC was done revealed a lymphocyte count of 6,000 lymphocytes/uI. The clinical signs became progressively worse, and the dog was euthanized two weeks after the initial presentation. Laboratory Results: Immunohistochemical (IHC) staining of bone marrow and lymph node sections revealed that tumor cells were negative for CD3 and CD79α. Gross Pathology: Marked generalized lymph node enlargement was found. Cut surfaces of the nodes bulged out and had a white homogeneous appearance. The spleen was enlarged and meaty. -
Supermicar Data Entry Instructions, 2007 363 Pp. Pdf Icon[PDF
SUPERMICAR TABLE OF CONTENTS Chapter I - Introduction to SuperMICAR ........................................... 1 A. History and Background .............................................. 1 Chapter II – The Death Certificate ..................................................... 3 Exercise 1 – Reading Death Certificate ........................... 7 Chapter III Basic Data Entry Instructions ....................................... 12 A. Creating a SuperMICAR File ....................................... 14 B. Entering and Saving Certificate Data........................... 18 C. Adding Certificates using SuperMICAR....................... 19 1. Opening a file........................................................ 19 2. Certificate.............................................................. 19 3. Sex........................................................................ 20 4. Date of Death........................................................ 20 5. Age: Number of Units ........................................... 20 6. Age: Unit............................................................... 20 7. Part I, Cause of Death .......................................... 21 8. Duration ................................................................ 22 9. Part II, Cause of Death ......................................... 22 10. Was Autopsy Performed....................................... 23 11. Were Autopsy Findings Available ......................... 23 12. Tobacco................................................................ 24 13. Pregnancy............................................................ -
Diagnosis and Treatment of Osteochondral Defects of the Ankle
SAOJ Winter 2009.qxd:Orthopaedics Vol3 No4 5/10/09 2:40 PM Page 44 Page 44 / SA ORTHOPAEDIC JOURNAL Winter 2009 CLINICAL ARTICLE C LINICAL A RTICLE Diagnosis and treatment of osteochondral defects of the ankle ML Reilingh, MD CJA van Bergen, MD CN van Dijk, MD, PhD Department of Orthopaedic Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands Corresponding address: Academic Medical Centre University of Amsterdam Department of Orthopaedic Surgery Prof Dr C Niek van Dijk PO Box 22660 1100 DD Amsterdam, The Netherlands Tel: + 31 20 566-2938 Fax: +31 20 566-9117 Email: [email protected], [email protected] Abstract An osteochondral defect of the talus is a lesion involving talar articular cartilage and subchondral bone. It is fre- quently caused by a traumatic event. The lesions may either heal, stabilise or progress to subchondral bone cysts. The subchondral cysts may develop due to the forcing of cartilaginous or synovial fluid with every step. Malalignment of the hindfoot plays an important role in the development of further degeneration. Plain radio- graphs may disclose the lesion. Modern imaging technology has enhanced the ability to fully evaluate and accu- rately determine the size and extent of the lesion, which are fundamental for proper treatment. Asymptomatic or low-symptomatic lesions are treated nonoperatively. For surgical treatment the following types of surgery are in clinical use: debridement and bone marrow stimulation, retrograde drilling, internal fixation, cancellous bone grafting, osteochondral autograft transfer, autologous chondrocyte implantation, and allograft transplantation. Although these are often successful, malalignment may persist with these treatment options. -
Β-Ecdysterone Prevents LPS-Induced Osteoclastogenesis by Regulating NF-Κb Pathway in Vitro
β-Ecdysterone Prevents LPS-Induced Osteoclastogenesis by Regulating NF-κB Pathway in Vitro Yuling Li Aliated Hospital of North Sichuan Medical College Jing Zhang Aliated Hospital of North Sichuan Medical College Caiping Yan Aliated Hospital of North Sichuan Medical College Qian Chen Aliated Hospital of North Sichuan Medical College Chao Xiang Aliated Hospital of North Sichuan Medical College Qingyan Zhang Aliated Hospital of North Sichuan Medical College Xingkuan Wang Aliated Hospital of North Sichuan Medical College ke jiang ( [email protected] ) Aliated Hospital of North Sichuan Medical College Research article Keywords: β-ecdysterone, lipopolysaccharide, osteoclast, NF-κB Posted Date: November 24th, 2020 DOI: https://doi.org/10.21203/rs.3.rs-112215/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/33 Abstract Background Lipopolysaccharide (LPS), a bacteria product, plays an important role in orthopedic diseases. Drugs that inhibit LPS-induced osteoclastogenesis are urgently needed for the prevention of bone destruction. Methods In this study, we evaluated the effect of β-ecdysterone (β-Ecd), a major component of Chinese herbal medicines derived from the root of Achyranthes bidentata BI on LPS-induced osteoclastogenesis in vitro and explored the mechanism underlying the effects of β-Ecd on this. Results We showed that β-Ecd inhibited LPS-induced osteoclast formation from osteoclast precursor RAW264.7 cells. The inhibition occurred through suppressing the production of osteoclast activating TNF-α, IL-1β, PGE2 and COX-2, which led to down-regulating expression of osteoclast-related genes including RANK, TRAF6, MMP-9, CK and CA. -
Dual-Delivery of Vancomycin and Icariin from an Injectable Calcium Phosphate Cement-Release System for Controlling Infection and Improving Bone Healing
MOLECULAR MEDICINE REPORTS 8: 1221-1227, 2013 Dual-delivery of vancomycin and icariin from an injectable calcium phosphate cement-release system for controlling infection and improving bone healing JIAN-GUO HUANG, LONG PANG, ZHI-RONG CHEN and XI-PENG TAN Orthopaedics Department Ward 3, General Hospital of Ningxia Medical University, Yinchuan, Xingqing 750004, P.R. China Received March 8, 2013; Accepted July 23, 2013 DOI: 10.3892/mmr.2013.1624 Abstract. Infectious bone diseases following severely at the same time. As infection is favored by the devitaliza- contaminated open fractures are frequently encountered in tion of bone, soft tissue and loss of skeletal stability, systemic clinical practice. It is difficult to successfully repair bone and administration of antibiotics is unable to achieve a sufficient control infection at the same time. To identify a better treat- local drug concentration. However, long-term administration ment method, we prepared a dual-drug release system that was of antibiotics may give rise to side-effects, including myelo- comprised of icariin (IC, a natural osteoinductive molecule), suppression, nephrotoxicity and drug-induced hepatitis (1). vancomycin (VA) and injectable calcium phosphate cement Conventional treatments, such as surgical debridement and (CPC). The ultrastructure of the dual-drug release system suction irrigation, are only able to control local infection. was evaluated by scanning electron microscopy and the For patients with nonunion or bone defects, these treatments biocompatibility was assessed by cell culture. In addition, the require two stages; control of infection followed by bone release kinetics of IC and VA were respectively investigated grafting (2-4). Therefore, the high cost and length of treatment by using high-performance liquid chromatography. -
Controlled Release of Drugs in Elextrosprayed Nanoparticles.Pdf
This document is downloaded from DR‑NTU (https://dr.ntu.edu.sg) Nanyang Technological University, Singapore. Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering Jayaraman, Praveena; Gandhimathi, Chinnasamy; Venugopal, Jayarama Reddy; Becker, David Laurence; Ramakrishna, Seeram; Srinivasan, Dinesh Kumar 2015 Jayaraman, P., Gandhimathi, C., Venugopal, J. R., Becker, D. L., Ramakrishna, S., & Srinivasan, D. K. (2015). Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering. Advanced Drug Delivery Reviews, 94, 77‑95. https://hdl.handle.net/10356/81690 https://doi.org/10.1016/j.addr.2015.09.007 © 2015 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Drug Delivery Reviews, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.addr.2015.09.007]. Downloaded on 28 Sep 2021 23:32:14 SGT ÔØ ÅÒÙ×Ö ÔØ Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering Praveena Jayaraman, Chinnasamy Gandhimathi, Jayarama Reddy Venu- gopal, David Laurence Becker, Seeram Ramakrishna, Dinesh Kumar Srinivasan PII: S0169-409X(15)00210-0 DOI: doi: 10.1016/j.addr.2015.09.007 Reference: ADR 12837 To appear in: Advanced Drug Delivery Reviews Received date: 15 February 2015 Revised date: 28 August 2015 Accepted date: 18 September 2015 Please cite this article as: Praveena Jayaraman, Chinnasamy Gandhimathi, Jayarama Reddy Venugopal, David Laurence Becker, Seeram Ramakrishna, Dinesh Kumar Srini- vasan, Controlled release of drugs in electrosprayed nanoparticles for bone tissue engi- neering, Advanced Drug Delivery Reviews (2015), doi: 10.1016/j.addr.2015.09.007 This is a PDF file of an unedited manuscript that has been accepted for publication.