First Aid for The® Psychiatry Clerkship
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Neuropsychiatric Symptoms in the Prodromal Stages of Dementia
1 Neuropsychiatric Symptoms in the Prodromal Stages of Dementia Florindo Stella, Márcia Radanovic, Márcio L.F. Balthazar, Paulo R. Canineu, Leonardo C. de Souza, Orestes V. Forlenza Curr Opin Psychiatry. 2014;27(3):230-235. Abstract and Introduction Abstract Purpose of Review. To critically discuss the neuropsychiatric symptoms in the prodromal stages of dementia in order to improve the early clinical diagnosis of cognitive and functional deterioration. Recent Findings. Current criteria for cognitive syndrome, including Alzheimer's disease, comprise the neuropsychiatric symptoms in addition to cognitive and functional decline. Although there is growing evidence that neuropsychiatric symptoms may precede the prodromal stages of dementia, these manifestations have received less attention than traditional clinical hallmarks such as cognitive and functional deterioration. Depression, anxiety, apathy, irritability, agitation, sleep disorders, among other symptoms, have been hypothesized to represent a prodromal stage of dementia or, at least, they increase the risk for conversion from minor neurocognitive disorder to major neurocognitive disorder. Longitudinal investigations have provided increased evidence of progression to dementia in individuals with minor neurocognitive disorder when neuropsychiatric symptoms also were present. Summary. Although neuropsychiatric symptoms are strongly associated with a higher risk of cognitive and functional deterioration, frequently the clinician does not acknowledge these conditions as increasing the -
Urge Syndrome and Urge Incontinence
Arch Dis Child: first published as 10.1136/adc.64.11.1629 on 1 November 1989. Downloaded from Archives of Disease in Childhood, 1989, 64, 1629-1634 Personal practice Urge syndrome and urge incontinence J D VAN GOOL* AND G A DE JONGEt *Department of Paediatric Nephrology, University Hospital for Children and Youth, Utrecht, and tDepartment of Paediatrics, Vrije Universiteit, Amsterdam, The Netherlands Diurnal enuresis is still the common denominator tractions give rise to urgency and frequency early in for children who wet their pants. A closer look at the filling phase; in the other pattern, incomplete children with daytime wetting, however, shows that relaxation of striated urethral and pelvic floor there are two distinct categories: one with classic muscles interrupts actual voiding and causes a diurnal enuresis and normal bladder function, and staccato urinary flow. the other with urinary incontinence caused by an As these patterns of bladder sphincter over- 'urge syndrome', with bladder sphincter dysfunction, activity are detectable with urodynamic techniques and a conspiciously high incidence of recurrent we decided to investigate prospectively a selected urinary tract infections. group of children of school age whose presenting Overactivity of the detrusor and urethral muscles symptoms were persistent daytime wetting, urgency, is now an established cause for bladder sphincter and frequency. copyright. dysfunction in children, and it is usually associated with symptoms such as urgency, frequency, daytime Patients wetting, and urinary tract infections. 1-5 The symp- toms of dysfunction induced by overactivity have in Ninety girls and three boys with urge incontinence the past been blamed on either the detrusor muscle and recurrent urinary tract infections were studied. -
Current P SYCHIATRY
Current p SYCHIATRY N ew Investigators Tips to manage and prevent discontinuation syndromes Informed tapering can protect patients when you stop a medication Sriram Ramaswamy, MD Shruti Malik, MBBS, MHSA Vijay Dewan, MD Instructor, department of psychiatry Foreign medical graduate Assistant professor Creighton University Department of psychiatry Omaha, NE University of Nebraska Medical Center Omaha, NE bruptly stopping common psychotropics New insights on psychotropic A —particularly antidepressants, benzodi- drug safety and side effects azepines, or atypical antipsychotics—can trigger a discontinuation syndrome, with: This paper was among those entered in the 2005 • rebound or relapse of original symptoms Promising New Investigators competition sponsored • uncomfortable new physical and psycho- by the Neuroleptic Malignant Syndrome Information Service (NMSIS). The theme of this year’s competition logical symptoms was “New insights on psychotropic drug safety and • physiologic withdrawal at times. side effects.” To increase health professionals’ awareness of URRENT SYCHIATRY 1 C P is honored to publish this peer- the risk of these adverse effects, this article reviewed, evidence-based article on a clinically describes discontinuation syndromes associated important topic for practicing psychiatrists. with various psychotropics and offers strategies to NMSIS is dedicated to reducing morbidity and anticipate, recognize, and manage them. mortality of NMS by improving medical and psychiatric care of patients with heat-related disorders; providing -
2019, Rev. 1 BH:Adult and Geriatric Psychiatry Adult and Geriatric Psychiatry
InterQual® 2019, Rev. 1 BH:Adult and Geriatric Psychiatry Adult and Geriatric Psychiatry Overview Select Level of Care Intensive Outpatient Program (1, 2) Notes InterQual® criteria (IQ) is confidential and proprietary information and is being provided to you solely as it pertains to the information requested. IQ may contain advanced clinical knowledge which we recommend you discuss with your physician upon disclosure to you. Use permitted by and subject to license with Change Healthcare LLC and/or one of its subsidiaries. IQ reflects clinical interpretations and analyses and cannot alone either (a) resolve medical ambiguities of particular situations; or (b) provide the sole basis for definitive decisions. IQ is intended solely for use as screening guidelines with respect to medical appropriateness of healthcare services. All ultimate care decisions are strictly and solely the obligation and responsibility of your health care provider. © 2019 Change Healthcare LLC and/or one of its subsidiaries. All Rights Reserved. Overview Informational Notes The Adult and Geriatric Psychiatry Criteria are for the review of patients who are ages 18 and older. InterQual® content contains numerous references to gender. Depending on the context, these references may refer to either genotypic or phenotypic gender. At the individual patient level, a variety of factors, including, but not limited to, gender identity and gender reassignment via surgery or hormonal manipulation, may affect the applicability of some InterQual criteria. This is most often the case with genetic testing and procedures that assume the presence of gender−specific anatomy. With these considerations in mind, all references to gender in InterQual have been reviewed and modified when appropriate. -
Hyponatremia and Psychotropic Drugs
DOI: 10.5772/intechopen.79029 ProvisionalChapter chapter 2 Hyponatremia and Psychotropic Drugs MireiaMireia Martínez Cortés Martínez Cortés and Pedro Gurillo MuñozPedro Gurillo Muñoz Additional information is available at the end of the chapter http://dx.doi.org/10.5772/intechopen.79029 Abstract Given the widespread use of psychotropic drugs in the population, it’s important to consider hyponatremia as an avoidable and reversible adverse effect and include the detection of high-risk subjects to establish safer medications, as well as early detection measures in routine clinical practice. Although hyponatremia has been especially associ- ated with serotonergic antidepressants (SSRIs), there is also an elevated risk with tricy- clics, duals and heterocyclic antidepressants, due to the different mechanisms of action at the renal tubular level and the release of ADH. Hyponatremia secondary to tricyclics with slow CYP2D6 metabolizers have higher plasma concentrations of antidepressants metabolized by CYP2D6. Hyponatremia secondary to SSRIs appears in the first week of treatment, it is “not dose-dependent” and normalization of natremia occurs between 2 and 20 days after stopping the medication. Bupropion, trazodone, mianserin, reboxetine and agomelatine are a safe alternative. Also antiepileptics have been related to hypona- tremia. Both typical and atypical antipsychotics have been exposed to an increased risk of hyponatremia, even after adjusted factors such as age, sex and comorbidity. Other factors that favor the onset of hyponatremia act synergistically with psychotropic drugs, such as: advanced age, female sex, concomitant diuretic intake, low body weight and low sodium levels; NSAID, ACEIs, and warm. Keywords: hyponatremia, antipsychotic, antidepressant, antiepileptic, psychotropic drugs 1. Introduction Hyponatremia is the most frequent hydroelectrolytic disorder in clinical practice, both in hospital and outpatient settings [1]. -
Diagnosis and Management of Urinary Incontinence in Childhood
Committee 9 Diagnosis and Management of Urinary Incontinence in Childhood Chairman S. TEKGUL (Turkey) Members R. JM NIJMAN (The Netherlands), P. H OEBEKE (Belgium), D. CANNING (USA), W.BOWER (Hong-Kong), A. VON GONTARD (Germany) 701 CONTENTS E. NEUROGENIC DETRUSOR A. INTRODUCTION SPHINCTER DYSFUNCTION B. EVALUATION IN CHILDREN F. SURGICAL MANAGEMENT WHO WET C. NOCTURNAL ENURESIS G. PSYCHOLOGICAL ASPECTS OF URINARY INCONTINENCE AND ENURESIS IN CHILDREN D. DAY AND NIGHTTIME INCONTINENCE 702 Diagnosis and Management of Urinary Incontinence in Childhood S. TEKGUL, R. JM NIJMAN, P. HOEBEKE, D. CANNING, W.BOWER, A. VON GONTARD In newborns the bladder has been traditionally described as “uninhibited”, and it has been assumed A. INTRODUCTION that micturition occurs automatically by a simple spinal cord reflex, with little or no mediation by the higher neural centres. However, studies have indicated that In this chapter the diagnostic and treatment modalities even in full-term foetuses and newborns, micturition of urinary incontinence in childhood will be discussed. is modulated by higher centres and the previous notion In order to understand the pathophysiology of the that voiding is spontaneous and mediated by a simple most frequently encountered problems in children the spinal reflex is an oversimplification [3]. Foetal normal development of bladder and sphincter control micturition seems to be a behavioural state-dependent will be discussed. event: intrauterine micturition is not randomly distributed between sleep and arousal, but occurs The underlying pathophysiology will be outlined and almost exclusively while the foetus is awake [3]. the specific investigations for children will be discussed. For general information on epidemiology and During the last trimester the intra-uterine urine urodynamic investigations the respective chapters production is much higher than in the postnatal period are to be consulted. -
Adult Onset Nocturnal Enuresis
0022-5347/01/1656-1914/0 ® THE JOURNAL OF UROLOGY Vol. 165, 1914–1917, June 2001 ® Copyright © 2001 by AMERICAN UROLOGICAL ASSOCIATION,INC. Printed in U.S.A. ADULT ONSET NOCTURNAL ENURESIS KYOKO SAKAMOTO AND JERRY G. BLAIVAS From the Department of Urology, Weil Medical College, Cornell University, Ithaca and Urocenter of New York, New York, New York, and Loyola University Medical Center, Maywood, Illinois ABSTRACT Purpose: We determined the etiology and prognostic significance of adult onset enuresis with absent daytime incontinence. Adult onset nocturnal enuresis unassociated with daytime incon- tinence is uncommon and there is a paucity of information about its incidence, significance, evaluation and treatment. We present a retrospective evaluation of this condition based on a database review of more than 3,000 consecutive patients referred for the evaluation of lower urinary tract symptoms. Materials and Methods: A database of 3,277 consecutive patients was searched for adult onset nocturnal enuresis. Patients with daytime incontinence were excluded from study. Evaluation consisted of history, physical examination, American Urological Association symptom score, voiding diary, uroflowmetry, estimation of post-void residual urine, video urodynamics, cystos- copy and radiographic evaluation of the upper tract. Results: Of 3,277 patients 8 (0.02%) had adult onset nocturnal enuresis without daytime incontinence as a primary complaint. Average American Urological Association symptom score was 12.6 (range 3 to 25), average maximum urine flow was 8.5 ml. per second (range 5 to 15) and average post-void residual urine volume was 350 ml. (range 50 to 489). All patients were men with severe prostatic or vesical neck obstruction as well as bilateral or unilateral hydronephrosis in 63%, a bladder diverticulum in 38%, vesicoureteral reflux in 50% and low bladder compliance in 50%. -
Geriatric Psychopharmacology: Anti-Depressants Amber Mackey, D.O
Geriatric Psychopharmacology: Anti-depressants Amber Mackey, D.O. University of Reno School of Medicine Department of Psychiatry Chief Resident, PGY-4 Pharmacologic issues in the elderly More likely to experience drug induced adverse events Cardiac effects: Prolonged QTc, arrhythmias, sudden death Peripheral/central anticholinergic effects: constipation, delirium, urinary retention, delirium, and cognitive dysfunction Antihistaminergic effects: sedation Antiadrenergic effects: postural hypotension Other effects: Hyponatremia, bleeding, altered bone metabolism Pharmacokinetic Organ system Change consequence Circulatory system Decreased concentration Increased or decreased of plasma albumin and free concentration of drugs increased α1-acid in plasma glycoprotein Gastrointestinal Table tract 20-1 Decreased intestinal and Decreased rate of drug splanchnic blood flow absorption Kidney Decreased glomerular Decreased renal filtration rate clearance of active metabolites Liver Decreased liver size; Decreased hepatic decreased hepatic blood clearance flow; variable effects on cytochrome P450 isozyme activity Muscle Decreased lean body mass Altered volume of and increased adipose distribution of lipid-soluble tissue drugs, leading to increased elimination half-life Table 20-1, Physiological changes in elderly persons associated with altered pharmacokinetics, American Psychiatric Publishing Textbook of Geriatric Psychiatry, Fifth Edition, Chapter 20: Psychopharmacology. Other issues Illnesses that effect the elderly also play a role in diminishing -
Revealing a Blind Spot on the Global Mental Health Map: Scoping Review
Revealing a blind spot on the global mental health map: scoping review of 25 years development of mental health care for people with severe mental illnesses in Central and Eastern Europe Authors PhDr. Petr Winkler* 1,3; Dzmitry Krupchanka* 1,3,4 PhD; Tessa Roberts2 MSc; Lucie Kondratova1 MSc; Vendula Machů1; Prof Cyril Höschl1 DrSc; Prof Norman Sartorius5 PhD; Prof Robert Van Voren6,7, 29, PhD; Oleg Aizberg8 PhD; Prof Istvan Bitter9 PhD; Arlinda Cerga-Pashoja2 PhD; Azra Deljkovic10 MD; Naim Fanaj11 PhD, ; Arunas Germanavicius12 PhD; Hristo Hinkov13 PhD; Aram Hovsepyan14 MD; Fuad N. Ismayilov1515, 30 DrSc; Prof Sladana Strkalj Ivezic1616,1717 DrSc; Marek Jarema1818 PhD; Vesna Jordanova1919 MD; Selma Kukić20; Nino Makhashvili2121 PhD; Brigita Novak Šarotar2222,2323 PhD; Oksana Plevachuk2424 PhD; Daria Smirnova2525 PhD; Bogdan Ioan Voinescu2626,2727 PhD; Jelena Vrublevska2828 MD; and Prof Graham Thornicroft PhD3 *Both authors contributed equally Institutions 1. Department of Social Psychiatry, National Institute of Mental Health, Prague, Czech Republic 2. Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK 3. Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK 4. Institute of Global Health, University of Geneva, Geneva, Switzerland 5. Association for the Improvement of Mental Health Programmes, Geneva, Switzerland 6. Ilia State University, Tbilisi, Georgia 7. Vytautas Magnus University, Kaunas, Lithuania 8. Department of Psychiatry and Narcology, Belarusian Medical Academy of Postgraduate Education, Minsk, Belarus 9. Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary 10. Mental Health Center, Health Care Center Pljevlja, Plevlja, Montenegro 11. Mental Health Center, Prizren, Kosovo 12. -
General Pharmacology
GENERAL PHARMACOLOGY Winners of “Nobel” prize for their contribution to pharmacology Year Name Contribution 1923 Frederick Banting Discovery of insulin John McLeod 1939 Gerhard Domagk Discovery of antibacterial effects of prontosil 1945 Sir Alexander Fleming Discovery of penicillin & its purification Ernst Boris Chain Sir Howard Walter Florey 1952 Selman Abraham Waksman Discovery of streptomycin 1982 Sir John R.Vane Discovery of prostaglandins 1999 Alfred G.Gilman Discovery of G proteins & their role in signal transduction in cells Martin Rodbell 1999 Arvid Carlson Discovery that dopamine is neurotransmitter in the brain whose depletion leads to symptoms of Parkinson’s disease Drug nomenclature: i. Chemical name ii. Non-proprietary name iii. Proprietary (Brand) name Source of drugs: Natural – plant /animal derivatives Synthetic/semisynthetic Plant Part Drug obtained Pilocarpus microphyllus Leaflets Pilocarpine Atropa belladonna Atropine Datura stramonium Physostigma venenosum dried, ripe seed Physostigmine Ephedra vulgaris Ephedrine Digitalis lanata Digoxin Strychnos toxifera Curare group of drugs Chondrodendron tomentosum Cannabis indica (Marijuana) Various parts are used ∆9Tetrahydrocannabinol (THC) Bhang - the dried leaves Ganja - the dried female inflorescence Charas- is the dried resinous extract from the flowering tops & leaves Papaver somniferum, P album Poppy seed pod/ Capsule Natural opiates such as morphine, codeine, thebaine Cinchona bark Quinine Vinca rosea periwinkle plant Vinca alkaloids Podophyllum peltatum the mayapple -
The Organic Chemistry of Drug Synthesis
The Organic Chemistry of Drug Synthesis VOLUME 2 DANIEL LEDNICER Mead Johnson and Company Evansville, Indiana LESTER A. MITSCHER The University of Kansas School of Pharmacy Department of Medicinal Chemistry Lawrence, Kansas A WILEY-INTERSCIENCE PUBLICATION JOHN WILEY AND SONS, New York • Chichester • Brisbane • Toronto Copyright © 1980 by John Wiley & Sons, Inc. All rights reserved. Published simultaneously in Canada. Reproduction or translation of any part of this work beyond that permitted by Sections 107 or 108 of the 1976 United States Copyright Act without the permission of the copyright owner is unlawful. Requests for permission or further information should be addressed to the Permissions Department, John Wiley & Sons, Inc. Library of Congress Cataloging in Publication Data: Lednicer, Daniel, 1929- The organic chemistry of drug synthesis. "A Wiley-lnterscience publication." 1. Chemistry, Medical and pharmaceutical. 2. Drugs. 3. Chemistry, Organic. I. Mitscher, Lester A., joint author. II. Title. RS421 .L423 615M 91 76-28387 ISBN 0-471-04392-3 Printed in the United States of America 10 987654321 It is our pleasure again to dedicate a book to our helpmeets: Beryle and Betty. "Has it ever occurred to you that medicinal chemists are just like compulsive gamblers: the next compound will be the real winner." R. L. Clark at the 16th National Medicinal Chemistry Symposium, June, 1978. vii Preface The reception accorded "Organic Chemistry of Drug Synthesis11 seems to us to indicate widespread interest in the organic chemistry involved in the search for new pharmaceutical agents. We are only too aware of the fact that the book deals with a limited segment of the field; the earlier volume cannot be considered either comprehensive or completely up to date. -
Neuroleptic Malignant Syndrome, Electroconvulsive Therapy and Other Treatments
NEUROLEPTIC MALIGNANT SYNDROME, ELECTROCONVULSIVE THERAPY AND OTHER TREATMENTS JASSIN M. JOURIA, MD Dr. Jassin M. Jouria is a medical doctor, professor of academic medicine, and medical author. He graduated from Ross University School of Medicine and has completed his clinical clerkship training in various teaching hospitals throughout New York, including King’s County Hospital Center and Brookdale Medical Center, among others. Dr. Jouria has passed all USMLE medical board exams, and has served as a test prep tutor and instructor for Kaplan. He has developed several medical courses and curricula for a variety of educational institutions. Dr. Jouria has also served on multiple levels in the academic field including faculty member and Department Chair. Dr. Jouria continues to serve as a Subject Matter Expert for several continuing education organizations covering multiple basic medical sciences. He has also developed several continuing medical education courses covering various topics in clinical medicine. Recently, Dr. Jouria has been contracted by the University of Miami/Jackson Memorial Hospital’s Department of Surgery to develop an e-module training series for trauma patient management. Dr. Jouria is currently authoring an academic textbook on Human Anatomy & Physiology. Abstract Neuroleptic Malignant Syndrome is both rare and potentially fatal. Health clinicians need to recognize signs and symptoms and ask the right questions to make an accurate diagnosis and begin treatment. While this condition is not entirely understood, its symptoms are recognizable and typically easily resolved with little or no long-term impact to the patient when caught early. A treatment and management plan must be implemented. Pharmacotherapy has not been consistently effective in all case reports of neuroleptic malignant syndrome.