Supplemenatry Table 4B - Ontology analysis of down-regulated

Function Systematic Common Apoptosis Regulator NM_012385.1_PROBE1 P8 Apoptosis Regulator 402269CB1_PROBE1 CD14 Apoptosis Regulator NM_013258.2_PROBE1 ASC

G-Protein Dependent 317557.1_PROBE1 GPR54 G-Protein Dependent NM_003979.2_PROBE1 RAI3 G-Protein Dependent NM_015149.1_PROBE1 RGL G-Protein Dependent NM_032049.1_PROBE1 AGTR1 G-Protein Dependent AL161952_PROBE1 GLUL G-Protein Dependent NM_018490.1_PROBE1 GPR48 G-Protein Dependent NM_001735.1_PROBE1 C5

GTPase mediated signal transduction NM_002547.1_PROBE1 OPHN1 GTPase mediated signal transduction NM_001175.1_PROBE1 ARHGDIB GTPase mediated signal transduction NM_014470.1_PROBE1 RHO6 GTPase mediated signal transduction NM_015149.1_PROBE1 RGL GTPase mediated signal transduction NM_002885.1_PROBE1 RAP1GA1

Oncogene 1383131.1_PROBE1

Antimicrobial NM_005127.1_PROBE1 CLECSF2

Blood factor 280276CB1_PROBE1 FGA Blood coagulation factor NM_020353.1_PROBE1 PLSCR4 Blood coagulation factor NM_000312.1_PROBE1 PROC Blood coagulation factor NM_005141.1_PROBE1 FGB Blood coagulation factor NM_030984.1_PROBE1 TBXAS1

Cell Adhesion NM_031366.1_PROBE1 COL4A3 Cell Adhesion NM_013281.1_PROBE1 FLRT3 Cell Adhesion X16354_PROBE1 CEACAM1 Cell Adhesion NM_001175.1_PROBE1 ARHGDIB Cell Adhesion NM_014470.1_PROBE1 RHO6 Cell Adhesion NM_005127.1_PROBE1 CLECSF2 Cell Adhesion 1501540.1_PROBE1 CDH13 Cell Adhesion NM_014880.1_PROBE1 DCL-1 Cell Adhesion NM_004063.1_PROBE1 CDH17 Cell Adhesion 280276CB1_PROBE1 FGA

Cell Cycle related function NM_003641.1_PROBE1 IFITM1 Cell Cycle related function 1399069.52_PROBE1 CDC10 Cell Cycle related function NM_013258.2_PROBE1 ASC

Cell Surface Linked Signal Transduction 317557.1_PROBE1 GPR54 Cell Surface Linked Signal Transduction NM_021135.1_PROBE1 RPS6KA2 Cell Surface Linked Signal Transduction NM_003979.2_PROBE1 RAI3 Cell Surface Linked Signal Transduction NM_015149.1_PROBE1 RGL Cell Surface Linked Signal Transduction NM_032049.1_PROBE1 AGTR1 Cell Surface Linked Signal Transduction AL161952_PROBE1 GLUL Cell Surface Linked Signal Transduction NM_018490.1_PROBE1 GPR48 Cell Surface Linked Signal Transduction NM_001735.1_PROBE1 C5 Cell Surface Linked Signal Transduction 1222317CB1_PROBE1 S100A4

Complement component 168592CB1_PROBE1 C4BPA Complement component NM_001735.1_PROBE1 C5

Cytokine M68874_PROBE1 PLA2G4A Cytokine NM_030984.1_PROBE1 TBXAS1

Developmental processes NM_002547.1_PROBE1 OPHN1 Developmental processes NM_013281.1_PROBE1 FLRT3 Developmental processes 402269CB1_PROBE1 CD14 Developmental processes NM_004653.1_PROBE1 SMCY Developmental processes NM_003641.1_PROBE1 IFITM1 Developmental processes NM_004616.1_PROBE1 TM4SF3 Developmental processes NM_001175.1_PROBE1 ARHGDIB Developmental processes NM_014470.1_PROBE1 RHO6 Developmental processes NM_003979.2_PROBE1 RAI3 Developmental processes NM_015149.1_PROBE1 RGL Developmental processes NM_015254.1_PROBE1 KIF13B Developmental processes NM_002885.1_PROBE1 RAP1GA1 Developmental processes NM_006472.1_PROBE1 TXNIP Developmental processes BF511168_PROBE1 MID1 Developmental processes 349705.1_PROBE1 USP9Y Developmental processes 1383131.1_PROBE1 Developmental processes 7487531CB1_PROBE1 INSL4 Developmental processes NM_006837.1_PROBE1 COPS5

DNA binding protein NM_014258.1_PROBE1 SYCP2 DNA binding protein NM_004653.1_PROBE1 SMCY DNA binding protein NM_004660.2_PROBE1 DDX3Y

Immunoglobulin AB051532_PROBE1 SEMA4B Immunoglobulin X16354_PROBE1 CEACAM1

Intracellular Signalling NM_002547.1_PROBE1 OPHN1 Intracellular Signalling NM_018658.1_PROBE1 KCNJ16 Intracellular Signalling NM_000720.1_PROBE1 CACNA1D Intracellular Signalling 1813005CB1_PROBE1 PDEF Intracellular Signalling 1000633.1_PROBE1 FSTL1 Intracellular Signalling NM_001175.1_PROBE1 ARHGDIB Intracellular Signalling NM_014470.1_PROBE1 RHO6 Intracellular Signalling NM_015149.1_PROBE1 RGL Intracellular Signalling 1103360.2_PROBE1 KCNG3 Intracellular Signalling NM_002885.1_PROBE1 RAP1GA1 Intracellular Signalling NM_021127.1_PROBE1 PMAIP1

MHC Antigen NM_002118.1_PROBE1 HLA-DMB MHC Antigen NM_006120.1_PROBE1 HLA-DMA

Microtubular Dynamics 1399069.52_PROBE1 CDC10 Microtubular Dynamics NM_015254.1_PROBE1 KIF13B Microtubular Dynamics BF511168_PROBE1 MID1 Microtubular Dynamics NM_018728.1_PROBE1 MYO5C Microtubular Dynamics NM_002381.2_PROBE1 MATN3

Molecular chaperone NM_002118.1_PROBE1 HLA-DMB Molecular chaperone NM_006120.1_PROBE1 HLA-DMA Molecular chaperone NM_021800.1_PROBE1 JDP1

Physiological Processes NM_031366.1_PROBE1 COL4A3 Physiological Processes NM_001305.2_PROBE1 CLDN4 Physiological Processes NM_002771.1_PROBE1 PRSS3 Physiological Processes NM_000312.1_PROBE1 PROC Physiological Processes NM_030984.1_PROBE1 TBXAS1 Physiological Processes 1454067.2_PROBE1 UQCRC2 Physiological Processes NM_012206.1_PROBE1 HAVCR1 Physiological Processes NM_004616.1_PROBE1 TM4SF3 Physiological Processes X16354_PROBE1 CEACAM1 Physiological Processes NM_006120.1_PROBE1 HLA-DMA Physiological Processes BF511168_PROBE1 MID1 Physiological Processes 1434821CB1_PROBE1 TFF1 Physiological Processes 7487531CB1_PROBE1 INSL4 Physiological Processes NM_002118.1_PROBE1 HLA-DMB Physiological Processes NM_020353.1_PROBE1 PLSCR4 Physiological Processes NM_005831.1_PROBE1 NDP52 Physiological Processes NM_001735.1_PROBE1 C5 Physiological Processes NM_005141.1_PROBE1 FGB Physiological Processes 280276CB1_PROBE1 FGA

RNA binding protein NM_016207.1_PROBE1 CPSF3 RNA binding protein NM_004660.2_PROBE1 DDX3Y

Transcription Factor 1813005CB1_PROBE1 PDEF Transcription Factor NM_001706.1_PROBE1 BCL6 Transcription Factor NM_003452.1_PROBE1 ZNF189 Transcription Factor 6802238CB1_PROBE1 FOXA2

Translation Factor NM_006837.1_PROBE1 COPS5

Transport 1507661.1_PROBE1 NDUFV2 Transport NM_001082.3_PROBE1 CYP4F2 Transport NM_018658.1_PROBE1 KCNJ16 Transport NM_020987.1_PROBE1 ANK3 Transport NM_000720.1_PROBE1 CACNA1D Transport NM_017784.1_PROBE1 OSBPL10 Transport NM_001062.1_PROBE1 TCN1 Transport NM_001633.1_PROBE1 AMBP Transport 1454067.2_PROBE1 UQCRC2 Transport NM_001461.1_PROBE1 FMO5 Transport 1103360.2_PROBE1 KCNG3 Transport NM_005639.1_PROBE1 SYT1 Transport 466845CB1_PROBE1 MB Transport NM_014585.1_PROBE1 SLC40A1 Transport NM_023944.1_PROBE1 CYP4F12 Transport NM_004925.2_PROBE1 AQP3 Transport NM_000096.1_PROBE1 CP Transport NM_006623.1_PROBE1 PHGDH Transport NM_004063.1_PROBE1 CDH17 Transport NM_020038.1_PROBE1 ABCC3 Transport NM_004827.1_PROBE1 ABCG2 Transport NM_001046.1_PROBE1 SLC12A2 Transport NM_000392.1_PROBE1 ABCC2 Transport NM_005628.1_PROBE1 SLC1A5 Transport 199593.1_PROBE1 SLC12A2 Transport NM_002083.1_PROBE1 GPX2

Ubiquitin 349705.1_PROBE1 USP9Y

Genbank Map GO biological process NM_012385 16p11.2 induction of apoptosis; cell growth NM_000591 5q31.1 phagocytosis; cell surface receptor linked signal tra NM_013258 16p12-p11.2 induction of apoptosis; negative regulation of cell c

AJ309020 19p13.3 G-protein coupled receptor protein signaling pathwa NM_003979 12p13-p12.3 signal transduction NM_015149 1q25.2 small GTPase mediated signal transduction; neurop NM_032049 3q21-q25 cytosolic calcium ion concentration elevation; G-pro AL161952 1q31 regulation of neurotransmitter levels; glutamine bio NM_018490 11p14-p13 G-protein coupled receptor protein signaling pathwa NM_001735 9q32-q34 response to pathogenic bacteria; activation of MAPK

NM_002547 Xq12 substrate-bound cell migration, cell extension; axon NM_001175 12p12.3 negative regulation of cell adhesion; Rho protein sig NM_014470 12q12-q13 negative regulation of cell adhesion; actin filament NM_015149 1q25.2 small GTPase mediated signal transduction; neurop NM_002885 1p36.1-p35 signal transduction

AB020860 8p21.3-p22

NM_005127 12p13-p12 antimicrobial humoral response (sensu Invertebrata

NM_021871 4q28 regulation of blood pressure; positive regulation of NM_020353 3q24 blood coagulation; phospholipid scrambling NM_000312 2q13-q14 proteolysis and peptidolysis; blood coagulation NM_005141 4q28 regulation of blood pressure; positive regulation of NM_030984 7q34-q35 blood coagulation

NM_031366 2q36-q37 negative regulation of cell proliferation; hearing; pa NM_013281 20p11 cell adhesion; signal transduction; biological_proce X16354 19q13.2 immune response NM_001175 12p12.3 negative regulation of cell adhesion; Rho protein sig NM_014470 12q12-q13 negative regulation of cell adhesion; actin filament NM_005127 12p13-p12 antimicrobial humoral response (sensu Invertebrata L34058 16q24.2-q24.3 homophilic cell adhesion NM_014880 2q24.2 heterophilic cell adhesion NM_004063 8q22.1 transport; homophilic cell adhesion NM_021871 4q28 regulation of blood pressure; positive regulation of

NM_003641 11p15.5 negative regulation of cell proliferation; cell surface AL050392 7p14.3-p14.1 cytokinesis; cell cycle NM_013258 16p12-p11.2 induction of apoptosis; negative regulation of cell c

AJ309020 19p13.3 G-protein coupled receptor protein signaling pathwa NM_021135 6q27 protein kinase cascade; protein amino acid phospho NM_003979 12p13-p12.3 signal transduction NM_015149 1q25.2 small GTPase mediated signal transduction; neurop NM_032049 3q21-q25 cytosolic calcium ion concentration elevation; G-pro AL161952 1q31 regulation of neurotransmitter levels; glutamine bio NM_018490 11p14-p13 G-protein coupled receptor protein signaling pathwa NM_001735 9q32-q34 response to pathogenic bacteria; activation of MAPK NM_002961 1q21 invasive growth

NM_000715 1q32 complement activation, classical pathway NM_001735 9q32-q34 response to pathogenic bacteria; activation of MAPK

M68874 1q25 eicosanoid metabolism; phospholipid catabolism; p NM_030984 7q34-q35 blood coagulation

NM_002547 Xq12 substrate-bound cell migration, cell extension; axon NM_013281 20p11 cell adhesion; signal transduction; biological_proce NM_000591 5q31.1 phagocytosis; cell surface receptor linked signal tra NM_004653 Yq11 regulation of transcription, DNA-dependent; sperma NM_003641 11p15.5 negative regulation of cell proliferation; cell surface NM_004616 12q14.1-q21.1 pathogenesis; protein amino acid glycosylation NM_001175 12p12.3 negative regulation of cell adhesion; Rho protein sig NM_014470 12q12-q13 negative regulation of cell adhesion; actin filament NM_003979 12p13-p12.3 signal transduction NM_015149 1q25.2 small GTPase mediated signal transduction; neurop NM_015254 8p21.1 microtubule-based movement; protein targeting; s NM_002885 1p36.1-p35 signal transduction NM_006472 1q21.2 sensory perception; signal transduction; biological_ AF041209 Xp22 pattern specification; microtubule cytoskeleton orga AF000986 Yq11.2 ubiquitin-dependent protein catabolism; spermatog AB020860 8p21.3-p22 NM_002195 9p24 pregnancy; development; cell proliferation; signal t NM_006837 8q13.1 protein biosynthesis; transcription from Pol II prom

NM_014258 20q13.33 synaptonemal complex formation; meiosis; cytokin NM_004653 Yq11 regulation of transcription, DNA-dependent; sperma NM_004660 Yq11

AB051532 15q25 development; neurogenesis X16354 19q13.2 immune response

NM_002547 Xq12 substrate-bound cell migration, cell extension; axon NM_018658 17q23.1-q24.2 potassium ion transport NM_000720 3p14.3 cation transport; calcium ion transport NM_012391 6p21.3 regulation of transcription, DNA-dependent; develo U06863 3q13.33 NM_001175 12p12.3 negative regulation of cell adhesion; Rho protein sig NM_014470 12q12-q13 negative regulation of cell adhesion; actin filament NM_015149 1q25.2 small GTPase mediated signal transduction; neurop NM_133329 2p22.1 cation transport; potassium ion transport NM_002885 1p36.1-p35 signal transduction NM_021127 18q21.32

NM_002118 6p21.3 perception of pest/pathogen/parasite; immune resp NM_006120 6p21.3 perception of pest/pathogen/parasite; immune resp

AL050392 7p14.3-p14.1 cytokinesis; cell cycle NM_015254 8p21.1 microtubule-based movement; protein targeting; s AF041209 Xp22 pattern specification; microtubule cytoskeleton orga NM_018728 15q21 NM_002381 2p24-p23 skeletal development

NM_002118 6p21.3 perception of pest/pathogen/parasite; immune resp NM_006120 6p21.3 perception of pest/pathogen/parasite; immune resp NM_021800 10q21.1

NM_031366 2q36-q37 negative regulation of cell proliferation; hearing; pa NM_001305 7q11.23 pathogenesis NM_002771 9p11.2 proteolysis and peptidolysis; digestion NM_000312 2q13-q14 proteolysis and peptidolysis; blood coagulation NM_030984 7q34-q35 blood coagulation BC000484 16p12 oxidative phosphorylation; aerobic respiration; elec NM_012206 5q33.2 NM_004616 12q14.1-q21.1 pathogenesis; protein amino acid glycosylation X16354 19q13.2 immune response NM_006120 6p21.3 perception of pest/pathogen/parasite; immune resp AF041209 Xp22 pattern specification; microtubule cytoskeleton orga NM_003225 21q22.3 cell growth and/or maintenance; defense response; NM_002195 9p24 pregnancy; development; cell proliferation; signal t NM_002118 6p21.3 perception of pest/pathogen/parasite; immune resp NM_020353 3q24 blood coagulation; phospholipid scrambling NM_005831 17q21.33 viral life cycle; invasive growth NM_001735 9q32-q34 response to pathogenic bacteria; activation of MAPK NM_005141 4q28 regulation of blood pressure; positive regulation of NM_021871 4q28 regulation of blood pressure; positive regulation of

NM_016207 2p25.2 mRNA processing NM_004660 Yq11

NM_012391 6p21.3 regulation of transcription, DNA-dependent; develo NM_001706 3q27 cell growth and/or maintenance; positive regulation NM_003452 9q22-q31 regulation of transcription, DNA-dependent; negativ NM_021784 20p11 regulation of transcription, DNA-dependent

NM_006837 8q13.1 protein biosynthesis; transcription from Pol II prom

M22538 18p11.31-p11.2 mitochondrial electron transport, NADH to ubiquino NM_001082 19pter-p13.11 electron transport; leukotriene metabolism NM_018658 17q23.1-q24.2 potassium ion transport NM_020987 10q21 cytoskeletal anchoring; nonselective vesicle transpo NM_000720 3p14.3 cation transport; calcium ion transport NM_017784 3p22.3 lipid transport; steroid metabolism NM_001062 11q11-q12 vitamin B12 transport; cobalt ion transport NM_001633 9q32-q33 transport BC000484 16p12 oxidative phosphorylation; aerobic respiration; elec NM_001461 1q21.1 electron transport; biological_process unknown NM_133329 2p22.1 cation transport; potassium ion transport NM_005639 12cen-q21 transport; synaptic transmission NM_005368 22q13.1 oxygen transport NM_014585 2q32 transport NM_023944 19p13.1 electron transport NM_004925 9p13 transport; excretion NM_000096 3q23-q25 iron ion homeostasis; copper ion homeostasis NM_006623 1p12 brain development; L-serine biosynthesis NM_004063 8q22.1 transport; homophilic cell adhesion NM_020038 17q22 transport NM_004827 4q22 drug resistance; transport NM_001046 5q23.3 chloride transport; amino acid transport; sodium io NM_000392 10q24 transport NM_005628 19q13.3 neutral amino acid transport; dicarboxylic acid tran AK025062 5q23.3 NM_002083 14q24.1 response to oxidative stress

AF000986 Yq11.2 ubiquitin-dependent protein catabolism; spermatog GO cellular component nucleus plasma membrane intracellular

integral to membrane membrane; integral to plasma membrane cellular_component unknown integral to plasma membrane osynthesis integral to membrane membrane attack complex; extracellular space

Rho GTPase activator activity cytoplasmic vesicle cytoskeleton; adherens junction cellular_component unknown GTPase activator activity

integral to plasma membrane

alpha chain; soluble fraction integral to membrane extracellular fibrinogen beta chain; soluble fraction

collagen type IV integral to plasma membrane integral to plasma membrane; membrane fraction cytoplasmic vesicle cytoskeleton; adherens junction integral to plasma membrane membrane sugar binding integral to plasma membrane; membrane fraction ; soluble fraction

integral to membrane; plasma membrane kinesin complex; actin cytoskeleton intracellular

integral to membrane nucleus membrane; integral to plasma membrane cellular_component unknown integral to plasma membrane osynthesis integral to membrane membrane attack complex; extracellular space calcium ion binding

extracellular space membrane attack complex; extracellular space

cytosol; integral to membrane

Rho GTPase activator activity integral to plasma membrane plasma membrane nucleus; cellular_component unknown integral to membrane; plasma membrane lysosome; integral to plasma membrane cytoplasmic vesicle cytoskeleton; adherens junction membrane; integral to plasma membrane cellular_component unknown kinesin complex; cytoskeleton GTPase activator activity cellular_component unknown kinesin complex; nucleus ubiquitin-specific protease activity; cysteine-type endopeptidase activity; ubiquitin

soluble fraction; extracellular space eukaryotic translation initiation factor 3 complex

nucleus; synaptonemal complex nucleus; cellular_component unknown ATP binding; RNA binding; DNA binding; ATP dependent helicase activity

integral to membrane integral to plasma membrane; membrane fraction

Rho GTPase activator activity integral to membrane voltage-gated calcium channel complex; integral to membrane nucleus extracellular space cytoplasmic vesicle cytoskeleton; adherens junction cellular_component unknown voltage-gated potassium channel complex; integral to membrane GTPase activator activity integral to membrane integral to membrane kinesin complex; actin cytoskeleton kinesin complex; cytoskeleton kinesin complex; nucleus kinesin complex; myosin kinesin complex; extracellular matrix integral to membrane integral to membrane chaperone activity collagen type IV tight junction; integral to plasma membrane extracellular extracellular mitochondrial electron transport chain; mitochondrion lysosome; integral to plasma membrane integral to plasma membrane; membrane fraction integral to membrane kinesin complex; nucleus growth factor activity soluble fraction; extracellular space integral to membrane integral to membrane nucleus membrane attack complex; extracellular space fibrinogen beta chain; soluble fraction fibrinogen alpha chain; soluble fraction nucleus ATP binding; RNA binding; DNA binding; ATP dependent helicase activity nucleus nucleus; mediator complex nucleus nucleus eukaryotic translation initiation factor 3 complex mitochondrion; membrane fraction membrane; microsome; endoplasmic reticulum integral to membrane Golgi apparatus; cytoskeleton; endoplasmic reticulum voltage-gated calcium channel complex; integral to membrane binding; cobalt ion transporter activity serine protease inhibitor activity; binding; transporter activity mitochondrial electron transport chain; mitochondrion microsome; integral to membrane voltage-gated potassium channel complex; integral to membrane synaptic vesicle; secretory vesicle; integral to membrane; synaptic junction oxygen transporter activity; electron transporter activity mitochondrial inner membrane membrane; microsome; endoplasmic reticulum integral to plasma membrane; membrane fraction extracellular space phosphoglycerate dehydrogenase activity; electron transporter activity; oxidoreduc integral to plasma membrane; membrane fraction integral to plasma membrane; membrane fraction integral to membrane integral to plasma membrane; membrane fraction integral to plasma membrane; membrane fraction integral to plasma membrane; membrane fraction cytoplasm ubiquitin-specific protease activity; cysteine-type endopeptidase activity; ubiquitin thiolesterase activity; hydrolase activity ctase activity

thiolesterase activity; hydrolase activity