Gras28 Flavoring Substances
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Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: a Review
molecules Review Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review Hanghang Lou 1,†, Lifei Hu 2,†, Hongyun Lu 1, Tianyu Wei 1 and Qihe Chen 1,* 1 Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China; [email protected] (H.L.); [email protected] (H.L.); [email protected] (T.W.) 2 Hubei Key Lab of Quality and Safety of Traditional Chinese Medicine & Health Food, Huangshi 435100, China; [email protected] * Correspondence: [email protected]; Tel.: +86-0571-8698-4316 † These authors are equally to this manuscript. Abstract: Flavonoids belong to a class of plant secondary metabolites that have a polyphenol structure. Flavonoids show extensive biological activity, such as antioxidative, anti-inflammatory, anti-mutagenic, anti-cancer, and antibacterial properties, so they are widely used in the food, phar- maceutical, and nutraceutical industries. However, traditional sources of flavonoids are no longer sufficient to meet current demands. In recent years, with the clarification of the biosynthetic pathway of flavonoids and the development of synthetic biology, it has become possible to use synthetic metabolic engineering methods with microorganisms as hosts to produce flavonoids. This article mainly reviews the biosynthetic pathways of flavonoids and the development of microbial expression systems for the production of flavonoids in order to provide a useful reference for further research on synthetic metabolic engineering of flavonoids. Meanwhile, the application of co-culture systems in the biosynthesis of flavonoids is emphasized in this review. Citation: Lou, H.; Hu, L.; Lu, H.; Wei, Keywords: flavonoids; metabolic engineering; co-culture system; biosynthesis; microbial cell factories T.; Chen, Q. -
FEMA GRAS 29 December 2019 SUPPLEMENTARY INFORMATION 1
SUPPLEMENTARY INFORMATION 1: Identity for Natural Flavor Complexes as Evaluated by the Expert Panel The Identification Description as Reviewed by the FEMA FEMA No.1 FEMA Primary Name Expert Panel Rebaudioside M ≥80%; Rebaudioside D 5-20%; Total 4895 Rebaudioside M steviol glycosides ≥95%. Glutamic acid 35-40%; Other amino acids 1-2%; Total Corynebacterium glutamicum corn nitrogen 6-7%; Aliphatic primary alcohols, aldehydes, 4907 syrup fermentation product carboxylic acids, acetals and esters containing additional oxygenated functional groups 1-2%; Minerals 9-11% Inosine 5´-monophosphate 20-25%; Amino acids 7-8%; Corynebacterium stationis corn 4908 Minerals 23-25%; water 28-37%; Other nucleotides 1-2%; syrup fermentation product Total nitrogen 5-8% Supraglucosylated steviol glycosides 70-80%; Rebaudioside Glucosylated steviol glycosides, 4909 A 14-20%; Steviol glycosides not further glucosylated, each 70-80% individually, not to exceed 3%; Maltodextrin 3-10% Supraglucosylated steviol glycosides 30-40%; Rebaudioside Glucosylated steviol glycosides, A 5-8%; Not more than 4% stevioside; All other individual 4910 40% steviol glycosides not further glucosylated <3%; Maltodextrin 45-60% Stevioside 70-80%; Rebaudioside A 13-18%; Steviobioside 1- 3%; Rebaudioside C 2-3%; Total glycosides (including 4911 Stevia extract stevioside, 70% Rebaudioside D, Rebaudioside B, Rebaudioside F, Dulcoside A, and Rubusoside) <3% Derived from hibiscus blossom calyces (Hibiscus sabdariffa L.) , Hibiscus blossom extract is measured as water 30-60%; 4912 Hibiscus -
Beneficial Effects of Stevioside on Ages, Blood Glucose, Lipid Profile and Renal Status in Streptozotocin-Induced Diabetic Rats
J Appl Biomed journal homepage: http://jab.zsf.jcu.cz DOI: 10.32725/jab.2019.013 Journal of Applied Biomedicine Original research article Beneficial effects of Stevioside on AGEs, blood glucose, lipid profile and renal status in streptozotocin-induced diabetic rats Urmila Aswar 1 *, Vinayak Gogawale 2, Pankaj Miniyar 2, Yugendra Patil 3 1 Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Erandwane, Pune, Maharashtra, India 2 STES’s Sinhgad Institute of Pharmacy, Savitribai Phule Pune University, Narhe, Pune, Maharashtra, India 3 National Chemical Laboratory, Pune, Maharashtra, India Abstract The advanced glycated end products (AGEs) are formed in the diabetic patients; it is a major cause of macrovascular and microvascular complications in diabetes. Clinically there is no treatment available for the AGEs. Stveoside (Stv), a sweetener has potent anti-diabetic and anti-oxidant activity. Hence, we investigated its use in prevention of AGEs formation using in vitro and in vivo models. Diabetes was induced by streptozotocin (STZ). These rats were kept without treatment till blood HbA1c was markedly increased. They were then divided into 5 groups and treated orally with vehicle or Metformin (MET) or Stv respectively for 28 days. Every 7th day, animals were tested for body weight and blood glucose (BG). On the last day of treatment, all the groups were evaluated for physiological and biochemical parameters, histopathology and AGEs; N-carboxymethyl-lysine (CML) estimation. Stv showed inhibition of AGEs in in vitro as well as in in vivo respectively. Positive effects were seen on the BG, lipid profile and urine parameters as well it showed reduced formation of CML. -
The Secrets of Spices and Herbs Gillian Schultz, Mhsc, RDN, CD
6/28/2020 The Secrets of Spices and Herbs Gillian Schultz, MHSc, RDN, CD 1 What’s the difference between herbs and spices? Herbs are the leaves of the plant, such as rosemary, sage, thyme, oregano, or cilantro. Spices come from the non-leafy parts, including roots, bark, berries, flowers, seeds etc. Example: Cilantro leaves are an herb while the seeds, coriander, are a spice. 2 1 6/28/2020 Cinnamon Active Ingredient: Cinnamaldehyde Potent antioxidant activity Can help to lower blood sugar Studies have shown that cinnamon can lower fasting blood sugars but not impact HbA1c averages. Dose: 0.5-2 teaspoons of cinnamon per day, or 1-6 grams Citations 1-10 3 Sage Salvere, which means "to save." Known for healing properties during the middle ages Current research indicates that sage may be able to improve brain function and memory, especially in people with Alzheimer's disease. Other studies also showed improvement in brain function in young and old Citations 11-13 4 2 6/28/2020 Peppermint Historically used in folk medicine and aromatherapy. Oily component contains the agents responsible for the health effects. Improves pain management in irritable bowel syndrome. Helps to reduce abdominal bloating. Peppermint in aromatherapy can help fight nausea. Citations 14-22 5 Turmeric Gives curry its yellow color. Most active ingredient: Curcumin Remarkably powerful antioxidant, helping to fight oxidative damage and boosting the body's own antioxidant enzymes Strongly anti-inflammatory Combine with black pepper. Citations 23-34 6 3 6/28/2020 Holy Basil Considered a sacred herb in India. -
FEMA GRAS 29 December 2019 SUPPLEMENTARY INFORMATION 1
SUPPLEMENTARY INFORMATION 1: Identity for Natural Flavor Complexes as Evaluated by the Expert Panel The Identification Description as Reviewed by the FEMA FEMA No.1 FEMA Primary Name Expert Panel Rebaudioside M ≥80%; Rebaudioside D 5-20%; Total 4895 Rebaudioside M steviol glycosides ≥95%. Glutamic acid 35-40%; Other amino acids 1-2%; Total Corynebacterium glutamicum corn nitrogen 6-7%; Aliphatic primary alcohols, aldehydes, 4907 syrup fermentation product carboxylic acids, acetals and esters containing additional oxygenated functional groups 1-2%; Minerals 9-11% Inosine 5´-monophosphate 20-25%; Amino acids 7-8%; Corynebacterium stationis corn 4908 Minerals 23-25%; water 28-37%; Other nucleotides 1-2%; syrup fermentation product Total nitrogen 5-8% Supraglucosylated steviol glycosides 70-80%; Rebaudioside Glucosylated steviol glycosides, 4909 A 14-20%; Steviol glycosides not further glucosylated, each 70-80% individually, not to exceed 3%; Maltodextrin 3-10% Supraglucosylated steviol glycosides 30-40%; Rebaudioside Glucosylated steviol glycosides, A 5-8%; Not more than 4% stevioside; All other individual 4910 40% steviol glycosides not further glucosylated <3%; Maltodextrin 45-60% Stevioside 70-80%; Rebaudioside A 13-18%; Steviobioside 1- 3%; Rebaudioside C 2-3%; Total glycosides (including 4911 Stevia extract stevioside, 70% Rebaudioside D, Rebaudioside B, Rebaudioside F, Dulcoside A, and Rubusoside) <3% Derived from hibiscus blossom calyces (Hibiscus sabdariffa L.) , Hibiscus blossom extract is measured as water 30-60%; 4912 Hibiscus -
Nutritional and Medicinal Properties of Stevia Rebaudiana
Review Article Curr Res Diabetes Obes J Volume 13 Issue 4 - July 2020 Copyright © All rights are reserved by Fasiha Ahsan DOI: 10.19080/CRDOJ.2020.13.555867 Nutritional and Medicinal Properties of Stevia Rebaudiana Fasiha Ahsan*, Shahid Bashir and Faiz-ul-Hassan Shah University Institute of Diet and Nutritional Sciences, The University of Lahore, Pakistan Submission: June 25, 2020; Published: July 16, 2020 *Corresponding author: Fasiha Ahsan, PhD Scholar, University Institute of Diet and Nutritional Sciences, The University of Lahore, Pakistan Abstract Researches on new molecules with the least toxic effects and better potency is on its way and more attention is being given upon medicinal plants for forcing away the above problems. Medicinal plants have been recognized as potential drug candidates. Stevia, a natural sweetener with medicinal properties and also having nutritional, therapeutic and industrial importance is being used all over the world. Stevia rebaudiana leaves are usually referred to as candy, sweet and honey leaves. Diterpene glycosides are responsible for its high sweetening potential of leaves. The phytochemical properties of bioactive chemicals present in stevia leaves are involves in maintaining the physiological functions of human body. Paper also highlights the importance of nutritional aspects of dried stevia leaves, metabolism of stevia, effects of it consumption on human health and clinical studies related to stevia ingestion. Various medicinal properties of stevia leaves discussed in paper like anti-hyperglycemia, anti-oxidative, hypotensive, nephro-protective, hepato protective, antibacterial and antifungal. Basic purpose of this review to understand the medicinalKeywords: potential Stevia; Diabetes;of stevia and Phytochemicals; its acceptance Medicinal as a significant plant; Steviol;raw material Nutrition; for human Disorders diet. -
In Chemistry, Glycosides Are Certain Molecules in Which a Sugar Part Is
GLYCOSIDES Glycosides may be defined as the organic compounds from plants or animal sources, which on enzymatic or acid hydrolysis give one or more sugar moieties along with non- sugar moiety. Glycosides play numerous important roles in living organisms. Many plants store important chemicals in the form of inactive glycosides; if these chemicals are needed, the glycosides are brought in contact with water and an enzyme, and the sugar part is broken off, making the chemical available for use. Many such plant glycosides are used as medications. In animals (including humans), poisons are often bound to sugar molecules in order to remove them from the body. Formally, a glycoside is any molecule in which a sugar group is bonded through its carbon atom to another group via an O-glycosidic bond or an S-glycosidic bond; glycosides involving the latter are also called thioglycosides. The sugar group is then known as the glycone and the non-sugar group as the aglycone or genin part of the glycoside. The glycone can consist of a single sugar group (monosaccharide) or several sugar groups (oligosaccharide). Classification Classification based on linkages Based on the linkage of sugar moiety to aglycone part 1. O-Glycoside:-Here the sugar is combined with alcoholic or phenolic hydroxyl function of aglycone.eg:-digitalis. 2. N-glycosides:-Here nitrogen of amino group is condensed with a sugar ,eg- Nucleoside 3. S-glycoside:-Here sugar is combined with sulphur of aglycone,eg- isothiocyanate glycosides. 4. C-glycosides:-By condensation of a sugar with a cabon atom, eg-Cascaroside, aloin. Glycosides can be classified by the glycone, by the type of glycosidic bond, and by the aglycone. -
Fabulous Flavour Combinations
Fabulous Flavour Combinations A Foodies Guide to Seasoning with Herbs and Spices by Di-Di Hoffman. This publication is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/. First Edition: January 2007 Second Edition: January 2011 Third Edition: December 2012 Copyright ©. All rights reserved. Check out Di-Di’s Profile at https://plus.google.com/111627006480548932387/ Login to your online Family Herbalist Library at http://herbclass.com/ to download more publications. Bouquet Garni Cuisine Organique incorporating the SA Herb Academy PO Box 15873 Lynn East Pretoria South Africa www.herb.co.za www.herbclass.com Contents Benefits of Seasoning with Herbs and Spices 1 Herbs and Spices Defined 2 3 Handy Flavour Building Cheat Sheets 3 Cheat Sheet 1: Basic Tastes 3 Cheat Sheet 2: Basic Aromatic Groups 3 Cheat Sheet 3: Loudness Groups 4 Soft to Moderate Volume 4 Loud Volume 5 Preparing Herbs for Maximum Flavour 5 Preparing Spices for Maximum Flavour 7 21 Flavour Combinations to Avoid 9 1 356+ Fabulous Flavour Combinations 9 33 Holy Grail Pairings 10 1 159 Duets Made in Heaven 10 197+ Fresh Herb Combinations 14 Please Speak Your Mind and Share the Love 15 Feast on Flavour Bites Follow @bgherbs on Twitter for a bite sized menu of herb tips, flavour combinations, flavour poetry and great recipes from around the blogosphere. Fabulous Flavour Combinations Fabulous Flavour Combinations A Foodies Guide to Seasoning with Herbs and Spices “Cooking is for capturing the taste of the food and then enhancing it, as a composer may take a theme and then delight us with his variations.” – Fernand Point If you’ve ever wondered what goes with what this guide is especially for you. -
Season with Herbs and Spices
Season with Herbs and Spices Meat, Fish, Poultry, and Eggs ______________________________________________________________________________________________ Beef-Allspice,basil, bay leaf, cardamon, chives, curry, Chicken or Turkey-Allspice, basil, bay leaf, cardamon, garlic, mace, marjoram, dry mustard, nutmeg, onion, cumin, curry, garlic, mace, marjoram, mushrooms, dry oregano, paprika, parsley, pepper, green peppers, sage, mustard, paprika, parsley, pepper, pineapple sauce, savory, tarragon, thyme, turmeric. rosemary, sage, savory, tarragon, thyme, turmeric. Pork-Basil, cardamom, cloves, curry, dill, garlic, mace, Fish-Bay leaf, chives, coriander, curry, dill, garlic, lemon marjoram, dry mustard, oregano, onion, parsley, pepper, juice, mace, marjoram, mushrooms, dry mustard, onion, rosemary, sage, thyme, turmeric. oregano, paprika, parsley, pepper, green peppers, sage, savory, tarragon, thyme, turmeric. Lamb-Basil, curry, dill, garlic, mace, marjoram, mint, Eggs-Basil, chili powder, chives, cumin, curry, mace, onion, oregano, parsley, pepper, rosemary, thyme, marjoram, dry mustard, onion, paprika, parsley, pepper, turmeric. green peppers, rosemary, savory, tarragon, thyme. Veal-Basil, bay leaf, curry, dill, garlic, ginger, mace, marjoram, oregano, paprika, parsley, peaches, pepper, rosemary, sage, savory, tarragon, thyme, turmeric. Vegetables Asparagus-Caraway seed, dry mustard, nutmeg, sesame Broccoli-Oregano, tarragon. seed. Cabbage-Basil, caraway seed, cinnamon,dill, mace, dry Carrots-Chili powder, cinnamon, ginger, mace, marjoram, mustard, -
Cooking Substitutions
COOKINGScience of Spices: Turmeric SUBSTITUTIONS General Facts The lists below are meant to help you replace ingredients with confidence. Dairy Flavor and texture are important considerations when substituting dairy products. The ingredients below are ordered from thinnest to thickest. If you don’t have the specific substitute on hand, then move up or down the list. Science of Spices: Turmeric Ingredient Substitution General Facts Half-and-half or heavy cream thinned with water, Milk evaporated milk, light coconut milk, light cream, oat milk, nut milk, soy milk. Thicken milk with a little cornstarch or flour (about Half-and-half 1 tablespoon per cup of liquid) or thin heavy cream with a splash of water. For 1 cup heavy cream, use 3/4 cup milk and 1/4 cup melted butter, or thicken 1 cup milk with 1 to 2 tablespoons cornstarch or flour. (Whisk milk into cornstarch or flour little by little.) Coconut milk, coconut cream (beware of increased Heavy Cream sweetness), or cream cheese whisked with a little water also work. Note: Alternatives won’t whip into fluffy whipped cream. If using butter to conduct heat, as in pan-frying, use olive oil or other fats. For flavor substitutions, like butter in risotto or Butter polenta, a number of creamy options like heavy cream or mascarpone will work. Tangy, textural ingredients like crema, crème fraîche, Creamy mascarpone, Neufchâtel, Quark, queso fresco, sour cream or Dairy Products yogurt of any variety can be used interchangeably. CheeseScience of Spices: Turmeric When substituting cheese, think about its purpose: Will it melt evenly in a pasta sauce, or spread easily on toast? If cooking, swap in one with a similar texture, but if using as an accent, there’s much more flexibility. -
Stevioside from Stevia Rebaudiana Bertoni Increases Insulin Sensitivity in 3T3-L1 Adipocytes
Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 938081, 8 pages http://dx.doi.org/10.1155/2013/938081 Research Article Stevioside from Stevia rebaudiana Bertoni Increases Insulin Sensitivity in 3T3-L1 Adipocytes Nabilatul Hani Mohd-Radzman,1 Wan Iryani Wan Ismail,1 Siti Safura Jaapar,1 Zainah Adam,2 and Aishah Adam1 1 Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia 2 Medical Technology Division, Malaysian Nuclear Agency, Bangi, 43000 Kajang, Selangor, Malaysia Correspondence should be addressed to Wan Iryani Wan Ismail; [email protected] Received 19 March 2013; Revised 13 October 2013; Accepted 24 October 2013 Academic Editor: Bechan Sharma Copyright © 2013 Nabilatul Hani Mohd-Radzman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Stevioside from Stevia rebaudiana has been reported to exert antihyperglycemic effects in both rat and human subjects. There have been few studies on these effects in vitro. In this paper, radioactive glucose uptake assay was implemented in order to assess improvements in insulin sensitivity in 3T3-L1 cells by elevation of glucose uptake following treatment with stevioside. Oil Red- O staining and MTT assay were utilized to confirm adipocyte differentiation and cell viability, respectively. Findings from this research showed a significant increase in absorbance values in mature adipocytes following Oil Red-O staining, confirming the differentiation process. Stevioside was noncytotoxic to 3T3-L1 cells as cell viability was reduced by a maximum of 17%, making it impossible to determine its IC50. -
Antinociceptive Effect of Methanol Extract of Dalbergia Sissoo Leaves in Mice Md
Mannan et al. BMC Complementary and Alternative Medicine (2017) 17:72 DOI 10.1186/s12906-017-1565-y RESEARCH ARTICLE Open Access Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice Md. Abdul Mannan*, Ambia Khatun and Md. Farhad Hossen Khan Abstract Background: Dalbergia sissoo DC. (Family: Fabaceae) is a medium to large deciduous tree, is locally called “shishu” in Bangladesh. It is used to treat sore throats, dysentery, syphilis, bronchitis, inflammations, infections, hernia, skin diseases, and gonorrhea. This study evaluated the antinociceptive effect of the methanol extract of D. sissoo leaves (MEDS) in mice. Methods: The extract was assessed for antinociceptive activity using chemical and heat induced pain models such as hot plate, tail immersion, acetic acid-induced writhing, formalin, glutamate, and cinnamaldehyde test models in mice at the doses of 100, 200, and 400 mg/kg (p.o.) respectively. Morphine sulphate (5 mg/kg, i.p.) and diclofenac sodium (10 mg/kg, i.p.) were used as reference analgesic drugs. To confirm the possible involvement of opioid receptor in the central antinociceptive effect of MEDS, naloxone was used to antagonize the effect. Results: MEDS demonstrated potent and dose-dependent antinociceptive activity in all the chemical and heat induced mice models (p < 0.001). The findings of this study indicate that the involvement of both peripheral and central antinociceptive mechanisms. The use of naloxone verified the association of opioid receptors in the central antinociceptive effect. Conclusions: This study indicated the peripheral and central antinociceptive activity of the leaves of D. sissoo. These results support the traditional use of this plant in different painful conditions.