Prevalence of Lyme Disease in the US Is 10-Times Higher Than
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A Poetic Narrative Inquiry Into the Lives of People with Lyme Disease
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Cardinal Scholar A POETIC NARRATIVE INQUIRY INTO THE LIVES OF PEOPLE WITH LYME DISEASE A DISSERTATION SUBMITTED TO THE GRADUATE SCHOOL IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE DOCTOR OF EDUCATION IN ADULT, HIGHER, AND COMMUNITY EDUCATION BY AMY M. BAIZE-WARD DISSERTATION ADVISOR: DR. MICHELLE GLOWACKI-DUDKA BALL STATE UNIVERSITY MUNCIE, INDIANA DECEMBER 2018 A POETIC NARRATIVE INQUIRY INTO THE LIVES OF PEOPLE WITH LYME DISEASE A DISSERTATION SUBMITTED TO THE GRAD SCHOOL IN PARTICAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE DOCTOR OF EDUCATION IN ADULT, HIGHER, AND COMMUNITY EDUCATION BY AMY M. BAIZE-WARD DISSERTATION ADVISOR: DR. MICHELLE GLOWACKI-DUDKA APPROVED BY: __________________________________________ __________ Michelle Glowacki-Dudka, Committee Chairperson Date ____________________________________ __________ Bo Chang, Department Representative Date __________________________________________ __________ Amanda Latz, Cognate Representative Date ___________________________________________ _________ James Jones, At Large Committee Member Date BALL STATE UNIVERSITY MUNCIE, IN DECEMBER 2018 Copyright © December 2018 Amy M. Baize-Ward All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the author. DEDICATION I have struggled for many years realizing that I could no longer share my story through song. I found my voice again, only this time through the power of the written word. That would never have happened without walking through my own journey with Lyme disease and believing in the path that God has for my life. -
Peer-Reviewed Evidence of Persistence of Lyme Disease
Peer-Reviewed Evidence of Persistence of Lyme Disease Spirochete Borrelia burgdorferi and Tick-Borne Diseases The following is a list of over 700 peer-reviewed articles that support the evidence of persistence of Lyme and other tick-borne diseases. It is organized into different categories—general, neuropsychiatric, dementia and congenital transmission. General: Persistence of Lyme Disease Spirochete Borrelia burgdorferi 1. Abele DC, Anders KH. The many faces and phases of borreliosis. J Am Acad Dermotol 1990; 23:401-410. [chronic Lyme borreliosis]. 2. Aberer E, Klade H. Cutaneous manifestations of Lyme borreliosis. Infection 1991; 19: 284-286. [chronic Lyme borreliosis]. 3. Aberer E, Breier F, Stanek G, and Schmidt B. Success and failure in the treatment of acrodermatitis chronica atrophicans skin rash. Infection 1996; 24: 85-87. 4. Aberer E, Kersten A, Klade H, Poitschek C, Jurecka W. Heterogeneity of Borrelia burgdorferi in the skin. Am J Dermatopathol 1996; 18(6): 571-519. 5. Akin E, McHugh Gl, Flavell RA, Fikrig E, Steere AC. The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 with mild and brief arthritis. Infect Immun 1999; 67: 173- 181. 6. Albert S, Schulze J, Riegel H, Brade V. Lyme arthritis in a 12-year-old patient after a latency period of 5 years. Infection 1999; 27(4-5): 286-288. 7. Allred DR. Babesiosis: persistence in the face of adversity. Trends Parasitol. 2003;19:51– 55. 8. Al-Robaiy S, Dihazi H, Kacza J, et al. Metamorphosis of Borrelia burgdorferi organisms―RNA, lipid and protein composition in context with the spirochete’s shape. -
Lyme Disease: a Comprehensive Approach to an Evolving Threat
S. HRG. 112–632 LYME DISEASE: A COMPREHENSIVE APPROACH TO AN EVOLVING THREAT FIELD HEARING OF THE COMMITTEE ON HEALTH, EDUCATION, LABOR, AND PENSIONS UNITED STATES SENATE ONE HUNDRED TWELFTH CONGRESS SECOND SESSION ON EXAMINING LYME DISEASE, FOCUSING ON A COMPREHENSIVE APPROACH TO AN EVOLVING THREAT AUGUST 30, 2012 (Stamford, CT) Printed for the use of the Committee on Health, Education, Labor, and Pensions ( Available via the World Wide Web: http://www.gpo.gov/fdsys/ U.S. GOVERNMENT PRINTING OFFICE 75–786 PDF WASHINGTON : 2012 For sale by the Superintendent of Documents, U.S. Government Printing Office Internet: bookstore.gpo.gov Phone: toll free (866) 512–1800; DC area (202) 512–1800 Fax: (202) 512–2104 Mail: Stop IDCC, Washington, DC 20402–0001 COMMITTEE ON HEALTH, EDUCATION, LABOR, AND PENSIONS TOM HARKIN, Iowa, Chairman BARBARA A. MIKULSKI, Maryland MICHAEL B. ENZI, Wyoming JEFF BINGAMAN, New Mexico LAMAR ALEXANDER, Tennessee PATTY MURRAY, Washington RICHARD BURR, North Carolina BERNARD SANDERS (I), Vermont JOHNNY ISAKSON, Georgia ROBERT P. CASEY, JR., Pennsylvania RAND PAUL, Kentucky KAY R. HAGAN, North Carolina ORRIN G. HATCH, Utah JEFF MERKLEY, Oregon JOHN MCCAIN, Arizona AL FRANKEN, Minnesota PAT ROBERTS, Kansas MICHAEL F. BENNET, Colorado LISA MURKOWSKI, Alaska SHELDON WHITEHOUSE, Rhode Island MARK KIRK, IIllinois RICHARD BLUMENTHAL, Connecticut PAMELA J. SMITH, Staff Director, Chief Counsel LAUREN MCFERRAN, Deputy Staff Director FRANK MACCHIAROLA, Republican Staff Director (II) CONTENTS STATEMENTS THURSDAY, AUGUST 30, 2012 Page Blumenthal, Hon. Richard, a U.S. Senator from the State of Connecticut, opening statement ................................................................................................ 1 Gillibrand, Hon. Kirsten E., a U.S. Senator from the State of New York ......... -
Antibodies of Patients with Lyme Disease to Components of the Ixodes Dammini Spirochete
Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete. A G Barbour, … , E Grunwaldt, A C Steere J Clin Invest. 1983;72(2):504-515. https://doi.org/10.1172/JCI110998. Research Article Lyme disease is an inflammatory disorder of skin, joints, nervous system, and heart. The disease is associated with a preceding tick bite and is ameliorated by penicillin treatment. A spirochete (IDS) isolated from Ixodes dammini ticks has been implicated as the etiologic agent of Lyme disease. We examined the antibody responses of Lyme disease patients to IDS lysate components in order to further understand the pathogenesis of this disease. The components were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, transferred to nitrocellulose, reacted with patients' sera, and the bound IgG was detected with 125I-labeled protein A (western blot). We found that (a) Lyme disease patients had antibodies to IDS components (b) most patients studied had antibodies to two components with apparent subunit molecular weights of 41,000 and 60,000, and (c) the patients' antibody responses during illness and remission were specific, for the most part, for the IDS. In contrast to the findings with Lyme disease sera, sera from controls showed little reactivity with IDS components in either the western blots or a derivative solid-phase radioimmunoassay. FIGURE 1FIGURE 2FIGURE 3FIGURE 4FIGURE 5 Find the latest version: https://jci.me/110998/pdf Antibodies of Patients with Lyme Disease to Components of the Ixodes dammini Spirochete ALAN G. BARBOUR, Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, Hamilton, Montana 59840 WILLY BURGDORFER, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, Montana 59840 EDGAR GRUNWALDT, 44 South Ferry Road, Shelter Island, New York 11964 ALLEN C. -
Morgellons Disease Open Access to Scientific and Medical Research DOI
Journal name: International Journal of General Medicine Article Designation: Review Year: 2016 Volume: 9 International Journal of General Medicine Dovepress Running head verso: Middelveen and Stricker Running head recto: Morgellons Disease open access to scientific and medical research DOI: http://dx.doi.org/10.2147/IJGM.S116608 Open Access Full Text Article REVIEW Morgellons disease: a filamentous borrelial dermatitis Marianne J Middelveen Abstract: Morgellons disease (MD) is a dermopathy characterized by multicolored filaments Raphael B Stricker that lie under, are embedded in, or project from skin. Although MD was initially considered to be a delusional disorder, recent studies have demonstrated that the dermopathy is associated with International Lyme and Associated Diseases Society, Bethesda, MD, USA tickborne infection, that the filaments are composed of keratin and collagen, and that they result from proliferation of keratinocytes and fibroblasts in epithelial tissue. Culture, histopathologi- cal and molecular evidence of spirochetal infection associated with MD has been presented in several published studies using a variety of techniques. Spirochetes genetically identified as Borrelia burgdorferi sensu stricto predominate as the infective agent in most of the Morgellons skin specimens studied so far. Other species of Borrelia including Borrelia garinii, Borrelia miyamotoi, and Borrelia hermsii have also been detected in skin specimens taken from MD Video abstract patients. The optimal treatment for MD remains to be determined. Keywords: Morgellons disease, dermatitis, Lyme disease, Borrelia burgdorferi, spirochetes Introduction Morgellons disease (MD) is an emerging dermopathy with worldwide distribution. The name “Morgellons” is derived from a disease recognized in the seventeenth cen- tury in French children by Sir Thomas Browne. -
Clinical Spectrum of Lyme Disease
European Journal of Clinical Microbiology & Infectious Diseases (2019) 38:201–208 https://doi.org/10.1007/s10096-018-3417-1 REVIEW Clinical spectrum of Lyme disease Jesus Alberto Cardenas-de la Garza1 & Estephania De la Cruz-Valadez1 & Jorge Ocampo-Candiani 1 & Oliverio Welsh1 Received: 4 September 2018 /Accepted: 30 October 2018 /Published online: 19 November 2018 # Springer-Verlag GmbH Germany, part of Springer Nature 2018 Abstract Lyme disease (borreliosis) is one of the most common vector-borne diseases worldwide. Its incidence and geographic expansion has been steadily increasing in the last decades. Lyme disease is caused by Borrelia burgdorferi sensu lato, a heterogeneous group of which three genospecies have been systematically associated to Lyme disease: B. burgdorferi sensu stricto Borrelia afzelii and Borrelia garinii. Geographical distribution and clinical manifestations vary according to the species involved. Lyme disease clinical manifestations may be divided into three stages. Early localized stage is characterized by erythema migrans in the tick bite site. Early disseminated stage may present multiple erythema migrans lesions, borrelial lymphocytoma, lyme neuroborreliosis, carditis, or arthritis. The late disseminated stage manifests with acordermatitis chronica atrophicans, lyme arthritis, and neurological symptoms. Diagnosis is challenging due to the varied clinical manifestations it may present and usually involves a two-step serological approach. In the current review, we present a thorough revision of the clinical manifestations Lyme disease may present. Additionally, history, microbiology, diagnosis, post-treatment Lyme disease syndrome, treatment, and prognosis are discussed. Keywords Lyme disease . Borrelia burgdorferi . Tick-borne diseases . Ixodes . Erythema migrans . Lyme neuroborreliosis History posteriorly meningitis, establishing a link between both mani- festations. -
Health Promoting Behaviors of Young Adults with Chronic Lyme Disease Patricia D
Walden University ScholarWorks Walden Dissertations and Doctoral Studies Walden Dissertations and Doctoral Studies Collection 2018 Health Promoting Behaviors of Young Adults with Chronic Lyme Disease Patricia D. Bolivar Walden University Follow this and additional works at: https://scholarworks.waldenu.edu/dissertations Part of the Epidemiology Commons This Dissertation is brought to you for free and open access by the Walden Dissertations and Doctoral Studies Collection at ScholarWorks. It has been accepted for inclusion in Walden Dissertations and Doctoral Studies by an authorized administrator of ScholarWorks. For more information, please contact [email protected]. Walden University College of Health Sciences This is to certify that the doctoral dissertation by Patricia Bolivar has been found to be complete and satisfactory in all respects, and that any and all revisions required by the review committee have been made. Review Committee Dr. Harold Griffin, Committee Chairperson, Public Health Faculty Dr. Lee Bewley, Committee Member, Public Health Faculty Dr. Vincent Agboto, University Reviewer, Public Health Faculty Chief Academic Officer Eric Riedel, Ph.D. Walden University 2018 Abstract Health Promoting Behaviors of Young Adults with Chronic Lyme Disease by Patricia D. Bolivar MS, California State University Los Angeles, 2001 BS, California State University Los Angeles, 1984 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Public Health Walden University February 2018 Abstract Lyme disease is the most prevalent arthropod-borne (tick) disease in North America. The disease is more prevalent in some Eastern and Central states than in Western states. The general problem is that, in southern California especially in Los Angeles County, both patients and practitioners fail to recognize the disease, resulting in misdiagnosis and delayed treatment. -
Are Mycobacterium Drugs Effective for Treatment Resistant Lyme Disease, Tick-Borne Co-Infections, and Autoimmune Disease?
Central JSM Arthritis Bringing Excellence in Open Access Case Report *Corresponding author Richard I. Horowitz, Hudson Valley Healing Arts Center, 4232 Albany Post Road, Hyde Park, New York 12538, Are Mycobacterium Drugs USA, Tel: 845-229-8977; Fax: 845-229-8930; Email: Submitted: 15 June 2016 Effective for Treatment Accepted: 14 July 2016 Published: 16 July 2016 Resistant Lyme Disease, Tick- Copyright © 2016 Horowitz et al. Borne Co-Infections, and OPEN ACCESS Keywords Autoimmune Disease? • Lyme disease • Bartonella Richard I. Horowitz* and Phyllis R. Freeman • Tularemia Hudson Valley Healing Arts Center, USA • Behçet’s Disease/Syndrome • Rheumatoid arthritis • Dapsone Abstract • Pyrazinamide Introduction: PTLDS/chronic Lyme disease may cause disabling symptoms with • Persister bacteria associated overlapping autoimmune manifestations, with few clinically effective published treatment options. We recently reported on the successful use of a mycobacterium drug, Dapsone, for those with PTLDS. We now report on the novel use of another mycobacterium drug, pyrazinamide, (PZA), in relieving resistant symptomatology secondary to Lyme disease and associated co-infections, while decreasing autoimmune manifestations with Behçet’s syndrome. Method: Disabling multi-systemic/arthritic symptoms persisted in a Lyme patient with co-infections (Bartonella, tularemia) and overlapping rheumatoid arthritis/ Behçet’s disease, despite several rotations of classic antibiotic and DMARD regimens. Dapsone, a published treatment protocol used for Behçet’s syndrome, recently has been demonstrated to be effective in the treatment of PTLDS/chronic Lyme disease and co-infections. It was superior to prior treatment regimens in relieving some resistant chronic tick-borne/autoimmune manifestations; however, it did not effectively treat the skin lesions and ulcers secondary to Behçet’s disease, nor significantly affect the granuloma formation, joint swelling, and pain associated with Lyme, Bartonella, and RA. -
The Lyme Times V 25 No 2
ABOUT LYMEDISEASE.ORG 25th Anniversary Issue We advocate nationally for quality accessible healthcare for patients with Lyme and other tick-borne diseases. We are committed to shaping health policy through advocacy, legal and ethical analysis, education, physician training and medical research. We communicate our message in print and online. We connect and educate the patient community through net- working and state online support groups. We take the pulse of the Lyme community through patient surveys. We analyze and archive information in our quarterly journal, The Lyme Times, and maintain an educational website at lymedisease.org. We publish regularly in peer- reviewed medical and health policy publications. Online Support Groups Participate in education and advocacy activities in your state. Learn about local resources and receive technical support for your efforts. Exchange information and patient support conveniently from your home. To find your own LymeDisease.org is grateful for the special online state-based group, go to: health.groups.yahoo.com/ support of the following sponsors: group/(yourstatename)lyme. Jill & Ira Auerbach Website Sandy Berenbaum, LCSW, BCD Dolly Curtis Visit our extensive educational website at lymedisease. Marcia Datson org. Discover the basics at Lyme 101, read news and Brian Fallon, MD analysis, and check the events calendar. Sign up for our free Ken & Kerry Fordyce email newsletter. Suzanne MacDonald Fratus Facebook In Memory of Paul E. Lavoie, MD Georgia Lyme Disease Association Keep on top of developing news and share your own ex- Thora Graves periences and opinions by joining the conversation on our Bob Lane, PhD Facebook page: facebook.com/lymedisease.org. -
Lyme Disease in Dark Skinned Populations of Appalachia
Review Article ISSN: 2574 -1241 DOI: 10.26717/BJSTR.2019.21.003583 Missed Diagnosis and the Development of Acute and Late Lyme Disease in Dark Skinned Populations of Appalachia James R Palmieri*, Anushri Kushwaha-Wagner, Abe-Melek Bekele, Jasyn Chang, Alison Nguyen, Nathanael N Hoskins, Raakhi Menon, Mohamed Mohamed and Susan L Meacham Department of Osteopathic Medicine, USA *Corresponding author: James R Palmieri, Department of Biomedical Sciences, Edward Via College of Osteopathic Medicine, Virginia Campus. USA ARTICLE INFO Abstract Received: August 28, 2019 Background: Lyme Disease (LD) is the most commonly reported vector-borne Published: September 11, 2019 disease in the United States, affecting over 300,000 people in the United States each year. If early LD goes undetected or is inadequately treated, the causative spirochete bacteria, Borrelia burgdorferi, can disseminate throughout the body and cause chronic symptoms Citation: James R Palmieri, Anushri Kus- that will characterize a patient with late LD. The incidence of LD is generally reported at hwaha-Wagner, Abe-Melek Bekele, Jasyn a higher rate in light-skinned patients as compared to dark-skinned patients. Chang, Alison Nguyen, et al. Missed Di- Aim: To assess the rate and causative factors of late Lyme Disease in dark-skinned agnosis and the Development of Acute individuals within the Appalachian region and encourage research into the need for early and Late Lyme Disease in Dark Skinned clinical evaluation and testing for at-risk patients. Populations of Appalachia. Biomed J Sci & Tech Res 21(2)-2019. BJSTR. Discussion: Healthcare providers are at risk of missing the diagnosis of acute Borrelia MS.ID.003583. -
Discovery of the Lyme Disease Spirochete and Its Relation to Tick Vectors
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by PubMed Central THE YALE JOURNAL OF BIOLOGY AND MEDICINE 57 (1984), 515-520 Discovery of the Lyme Disease Spirochete and Its Relation to Tick Vectors WILLY BURGDORFER, Ph.D. Department of Health and Human Services, Public Health Service, National Institutes ofHealth, National Institute ofAllergy and Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, Montana Received November 16, 1983 The various hypotheses concerning the etiologic agent of erytheina chroniicum migranis of Europe and of Lyme disease in the United States are reviewed, and an account of evenlts tllat led to the discovery of the causative spirochetal agent in Ixodes dammini is presented. Spiro- chetes morphologically and antigenically similar, if not identical to, the organism detected in L. dammini were also found for the first time in Ixodes pacificus and Ixodes ricinus, the vectors hitherto incriminated, respectively, in western United States and Europe. In most infected ticks, spirochetal developmenit was found to be limnited to the midgut. Ticks with generalized infections were shown to transmit spirochetes via eggs, but inifectionis de- creased in intensity and became restricted to the central ganglion as filial ticks developed to adults. Although the mechanisms of transmission to a host are still under inlvestigation, the spiro- chetes may be transmitted by saliva of ticks with generalized infectionis and possibly also by regurgitation of infected gut contents, or even by means of infected fecal material. Ever since the first description of Erythema chronicum migrans (ECM) in Europe [1] and of Lyme disease in the United States [2], tick-transmitted toxins, viruses, rickettsiae, and spirochetes have been considered as possible causes of these ailments. -
Willy Burgdorfer Oral History
INTRODUCTORY NOTE Deirdre Boggs: I interviewed Dr. Willy Burgdorfer on tape in three different sessions, beginning on July 10, 2001, and ending in August. After reading the transcribed version of the interviews, Dr. Burgdorfer wished to make some changes and refinements to the answers that he gave to the interview questions. He finished making the desired changes at the beginning of October 2001. The following transcription reflects Dr. Burgdorfer's oral responses to the interview questions as later edited and supplemented by Dr. Burgdorfer. This is Deirdre Boggs of Historical Research Associates interviewing Dr. Willy Burgdorfer in Hamilton, Montana on July 10, 2001. The interview is being done at the request of the National Institutes of Health. DB: Dr. Burgdorfer, I'd like to begin by asking you where you grew up and what your first language was? WB: I was born and grew up in Basel, Switzerland. Basel is in the northwest corner of the country where German is spoken, so my mother tongue is German. DB: Where and how did you learn to speak English? WB: I became exposed to the English language for four years in gymnasium. DB: Can you still speak German? WB: Oh, yes. DB: And do you ever speak German anymore? WB: Yes, I do. Some of my correspondence is still written in German. DB: Although you've been speaking English for many years. Isn't that true? WB: Yes. DB: For over 50 years? WB: That's true. DB: Did your parents encourage you to attend university? 1 WB: Yes, both my mother and father did.