Ann. N.Y. Acad. Sci. ISSN 0077-8923
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES Issue: Pharmaceutical Science to Improve the Human Condition: Prix Galien 2014
The development of SERI R Surgical Scaffold, an engineered biological scaffold
Mark Jewell,1 William Daunch,2 Bradley Bengtson,3 and Enrico Mortarino2 1Division of Plastic Surgery, Oregon Health & Science University, Portland, Oregon. 2Allergan, Inc., Medford, Massachusetts. 3Bengtson Center for Aesthetics and Plastic Surgery and Associate Professor, Michigan State University, Grand Rapids, Michigan
Address for correspondence: Mark Jewell, M.D., 10 Coburg Rd, Suite 300, Eugene, OR 97401. [email protected]
The primary goal of reconstructive and revision surgery is to restore, repair, rebuild, and support damaged, weakened, or absent tissue. There are numerous approaches for soft tissue support and repair, including the use of autologous tissue, human- or animal-derived acellular dermal matrices, absorbable or permanent synthetic mesh, and, now, a new class of bioresorbable protein scaffold. Although many factors influence the choice of surgical approach and the specific product used for soft tissue support and repair, the goal is to improve long-term outcomes while minimizing complications and recurrences requiring further revisional surgery. In this review, the basic science, clinical characteristics, and clinical applications of SERI R Surgical Scaffold, a novel, engineered, highly purified silk product for soft tissue support and repair will be presented.