THE CAMPBELL FOUNDATION MMOMENTUM Enhancing Quality of A Special Edition 2005

Life Through the Science

of Orthopaedic Medicine

MEMPHIS Musculoskeletal

RESEARCH

INSTITUTE

Many minds, one goal: a better life for our patients H ISTORIC H IGHLIGHTS MESSAGE FROM THE CHAIRMAN

1909 On behalf of the Board of Trustees of The Campbell Dr. Willis C. Campbell opened his practice in Memphis. Foundation, it is with great pleasure that I present this He would become one of the world’s preeminent leaders in the advancement of orthopaedic medicine. special edition of Momentum, a publication designed to 1910 inform our closest friends and supporters of achievements Dr. Campbell organized the Department of Orthopaedic in musculoskeletal research and education at The Surgery at the UT School of Medicine in Memphis. Campbell Foundation and our partners Campbell Clinic 1924 and the University of Tennessee-Campbell Clinic Dr. Campbell established the orthopaedic residency program at UT-Memphis. The program has trained Department of Orthopaedic Surgery. over 450 of the world’s best orthopaedic surgeons. THE CRITICAL NEED 1933 The American Academy of Orthopaedic Surgeons In the United States, musculoskeletal conditions take an (AAOS) was founded by Dr. Campbell, who served as enormous toll on our society, costing an estimated $254 its first president. Campbell Clinic surgeons Harold Boyd, Hugh Smith, Rocco Calandruccio, and Terry billion every year and accounting for 102 million visits to Canale succeeded Dr. Campbell in leading AAOS. physician offices, 10.2 million hospital outpatient visits, 1939 and 25 million emergency department visits each year. Dr. Willis Campbell wrote and published the first Campbell’s Operative Orthopaedics. Since that time, the Conditions such as osteoporosis, osteoarthritis, rheuma- Campbell Clinic staff has updated the text every five to toid arthritis, back pain, spinal disorders, and fractures seven years. Used by surgeon all over the world, review- ers today call it “the bible of orthopaedic surgery.” The affect millions of people — problems that are predicted to 10th edition was published in 2002 in seven languages. double in the next 20 years with the aging of the Baby 1946 Boomers. Many children also suffer from crippling bone To perpetuate Willis Campbell’s commitment to the and joint diseases, impeding normal development and advancement of orthopaedic medicine, his partners — Drs. Spencer Speed, Harold Boyd, J.F. Hamilton, and preventing them from experiencing full and healthy lives. Hugh Smith — established The Campbell Foundation.

1990 Formalizing a long-standing informal arrangement, the department was officially designated the UT-Campbell Clinic Department of Orthopaedic Surgery. All Campbell Clinic surgeons hold faculty appointments in the depart- ment and work closely with its research scientists. 2003 Community and corporate leaders joined the Founda- tion’s Board of Trustees and implemented a formal development program to encourage support from grateful patients, alumni, foundations and industry. 2004 The Board of Trustees adopted a strategic plan for research and committed to build a world-class musculoskeletal research institute. The Campbell residency program marked its 80th anniversary.

RESEARCH FEATURE 4 SUCCESS STORY 7 FOUNDATION GIFTS 10 NEW BOARD MEMBERS 12 GALA 12 2 C AMPBELL F OUNDATION S PECIAL E DITION 2005

• We will make one of the country’s most distin- THE SEARCH FOR SOLUTIONS Given this growing health crisis and many unsolved guished orthopaedic residency and fellowship programs musculoskeletal disorders, we feel there is much more even better. that we must do. The Campbell Foundation has committed • We will invest in our community’s health by provid- to build one of the nation’s premier sites for musculo- ing the finest care available for children and adults with skeletal research and education. We have worked for the musculoskeletal injuries and disorders, regardless of their last year to develop a strategic plan for a world-class ability to pay. musculoskeletal institute and position ourselves to In this issue, we share with you the blueprint of our accomplish our vision. plans for building the Memphis Musculoskeletal Research Institute. Ultimately the success of our efforts PROGRESS WE’VE MADE will depend on your support. Our work together holds Thanks to the generous support of our patients, enormous promise for the future of medicine, while alumni, trustees, physicians, and industry partners dur- offering patients hope for better, more active lives. ing 2004, we have laid the foundation for the Institute’s Please join us in making 2005 an outstanding year success. Our goals for the years ahead are clear, and we for musculoskeletal health. will pursue them with determination and vigor: • We will devote the finest physicians and scientists available to lead our research efforts in areas such as arthritis, osteoporosis, cartilage regeneration, joint replacement, trauma care, bone tumors, and children’s bone and joint diseases. • We will provide increased seed funding to launch important research and bring new solutions for debili- Jack R. Blair C HAIRMAN, BOARD OF T RUSTEES tating problems to our patients much sooner.

RESEARCH NEWS 14 ALUMNI NEWS 16 DONORS 18 3

F EATURE

MEMPHIS Musculoskeletal

RESEARCH INSTITUTE

When Jack Blair imagines the Memphis Musculoskeletal Research Institute, the first thing that comes mind isn’t bricks and mortar and sleek laboratories filled OUR GOAL: with high-tech equipment. Blair, Chairman of the Board of The Campbell Foundation, closes his eyes and BRING PEOPLE envisions top scientists crossing paths in an elevator, sharing notes on the way down and gaining insight that will be helpful in musculoskeletal research they may be pursuing individually or jointly. TOGETHER TO WORK He sees biomedical engineers from two different institutions working together on a product or technique that could help relieve the pain of arthritis sufferers MORE EFFICIENTLY everywhere. He sees scientists, clinicians, educators, and private companies collabo- rating to help accelerate the time required to get an innovation from fundamental AND EFFECTIVELY research to clinical application. “The Memphis Musculoskeletal Research Institute (MMRI) is about bringing CREATING SOLUTIONS people together to work more efficiently and effectively,” said Blair. “It’s about maximizing our resources and taking advantage of existing opportunities so we can THAT REACH create solutions that reach patients sooner. We’re in the right place, and this is the right time, to make the dream of a collaborative research facility a reality.” PATIENTS SOONER MEETING A GROWING NEED Musculoskeletal disorders and conditions represent the most frequent cause of disability worldwide. Americans spend an estimated $254 billion annually on musculoskeletal-related problems, which count for 102 million visits to doctor’s offices each year. Arthritis affects one in three people in the U.S., and half of all Americans fracture a bone and receive treatment for it before age 65. Americans are living longer, and the “Baby Boom” generation is entering the years when musculoskeletal disorders are most prevalent. Increasing numbers of Americans are obese. These and other factors will create increasing demand for products and therapies to serve patients with musculoskeletal diseases and disorders. While a vast array of new products and therapies are in the research-and-devel- opment pipeline, the time span between “bench” and “bedside” can be achingly slow. What’s needed, many believe, is interdisciplinary cooperation between the numerous parties working to develop new therapies and products, with emphasis on translational research that bridges the gap between basic research and clinical treatment. The National Institutes of Health, the largest funding source for medical research, is increasingly favoring translational research that is multi-disciplinary and collaborative.

4 C AMPBELL F OUNDATION R ESEARCH

THE RIGHT PLACE, THE RIGHT TIME Plans to create a musculoskeletal research facility in Memphis have proceeded alongside efforts to advance the city as a prime location for biomedical research. Since 2000, the Memphis Bioworks Foundation has encouraged and sought funding for biomedical commercial entities to locate in the UT-Baptist Research Park being developed on the site of the old Baptist-Medical Center facility on Union Avenue. The Memphis Musculoskeletal Research Institute will be one of the park’s major tenants. Within the Memphis area, musculoskeletal research occurs in multiple institutions and venues. Uniquely, Memphis is the home of:

• Campbell Clinic, one of the top 8% of orthopaedic training centers in the United States training 40 orthopaedic residents annually, • The University of Tennessee Health Science Center, • The University of Memphis, • Three major musculoskeletal product manufacturers (Medtronic Sofamor-Danek, Smith & Nephew Orthopaedics and Wright Medical Technology), and • A dedicated local seed/start-up venture capital firm

All of these entities conduct research into orthopaedic and spinal diseases and disorders or serve that market. No other city or region in the U.S. possesses all of these elements focused on the muscu- loskeletal market. Memphis entrepreneur Pitt Hyde, founder and Chairman of the Memphis Bioworks Foundation, said, “Our vision is to establish Memphis as an internationally-recognized center in the biosciences, and the Memphis Musculoskeletal Institute is a key component in that vision. There is an unparal- leled convergence of outstanding musculoskeletal-related companies and institutions in the Memphis area, making this a natural location for a collaborative facility. The Memphis Bioworks Foundation is committed to advancing MMRI and helping it succeed.” Dr. Steve Bares, President and Executive Director of the Memphis Bioworks Foundation, said, “The Memphis Musculoskeletal Research Institute is a significant step forward in the local strategy to build on our orthopaedics, neural and implantable device industry. The Institute will strengthen research in these areas and further the region’s focus on translation and commercialization with the ultimate goal of improving life for patients with musculoskeletal diseases and disorders.”

GOALS AND RESEARCH FOCUS In the past, collaboration between local researchers from different institutions has been some- what limited, and musculoskeletal manufacturers have not collaborated to any substantial degree. There has also been a funding gap for translational research that seeks to use concepts that arise from basic research and develop them for use with patients. The goal of the Memphis Musculoskeletal Research Institute will be to facilitate the transition of fundamental research to clinical application. The MMRI would:

• Foster collaborative research and development programs among scientists, clinicians, educators and commercial entities; • Educate scientists and clinicians in the latest research on treatments and therapies for musculoskeletal diseases and disorders; and • Provide seed funding for work that seeks to develop commercially viable musculoskeletal products, treatments and devices.

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6 O COLLABORA A FOR LOCATION NATURAL A AREA of theMemphisBioworksFoundation — PittHyde,FounderandChair FACILITY TIVE THE IN AND COMPANIES RELATED “T MUSCULOSKELETAL OUTSTANDING OF CONVERGENCE UNPARALLELED HERE INSTITUTIONS , AIGTHIS MAKING M SAN IS EMPHIS .”

MMRIman - - NTHE IN • Inflammatory arthritis Inflammatory • Traumatic anddegenerativejointdisease • Metabolicbonediseases • andtissueengineering Orthobiologics • ofthecollaboratorsandinclude: strengths MMRI willcapitalizeonresearch at research for targeted areas members.Key and interactionbetweenamongstaff byindividuallaboratories.Suchadesignencouragescollaboration surrounded the core, rative pr attended,andideasforseveralcollabo- 85researchers ofMMRI.Approximately part expectedtobe whoare tobringtogethersomeoftheparties Conference Research forMMRI. thecostofhiringaDirector The CampbellFoundationunderwrite costsoftheMemphisMusculoskeletalInstitute.Thefundswillhelp start-up toward to theInstitute’soperation. fortheMMRI.Additionally,community support ithascommittedfinancialresources andworkedtosecure advance thatgoal,theFoundationhasledplanningeffort inhelping Instituteholdssignificantpromise Memphis MusculoskeletalResearch goalofTheCampbellFoundation.Becausethe musculoskeletal diseasesisacore A musculoskeletal r basistostimulatecontinueddialogue,connectivityandcollaborationamong regular Metabolic BoneDisease P Inflammatory Arthritis Inflammatory Orthobiologics and T Degenerative Joint Genetic Factorsin issue Engineering LA In November 2004, The Campbell Foundation sponsored aMusculoskeletal In November2004,TheCampbellFoundationsponsored Recently of andtreatments Finding newsolutionsanddiscoveriesintothecauses,cures, Planners envision the building that houses MMRI will consist of common areas in Planners envisionthebuildingthathousesMMRIwillconsistofcommonareas Resear E OEFOR ROLE KEY Basic Arthritis IGTHE CING Disease ojects wer R , theMemphisBioworksFoundationmadeacommitmentof$500,000 ch M ESEARCH EMPHIS esear e generated at the meeting. The conference will be offered ona willbeoffered e generatedatthemeeting.Theconference M chers. USCUL Translational T M - Biocompatibility Animal Models Biomechanics Resear TO Microscopy HE USCULOSKELETAL Materials Science -M C OSKELETAL AMPBELL ch ARKET Biomedicalengineering • Computationalmodeling • Biomaterialsandbiomechanics • Geneticfactorsinarthritis • C Pediatric Orthopaedics Other Musculoskeletal ONTINUUM R F Sports Medicine Reconstr Resear R OUNDATION Clinical Conditions ESEAR Total Joint Trauma ESEARCH Spine uction ch CH I I NSTITUTE NSTITUTE Estimated Procedures/yr. Annual GrowthRate 350K Pediatrics 300K Trauma 600K Spor Patients 800K Joints 700K Spine 500K Other 12% CAGR 12% 10% 20% 6% 6% ts S UCCESS S TORY

S UCCESS S TORY

New surgical method means small incisions, big rewards for hip replacement patients

A n advanced technique in hip replacement surgery to a restaurant for lunch. She had come to dread grocery that requires two small incisions instead of one long one shopping, and Christmas shopping was even worse. can mean less pain, shorter hospital stays, and a quicker “It’s pretty bad when you hate to go shopping, even recovery for some patients needing hip replacement though you love to shop,” Ms. Buchanan said. “It surgery. reached the point where 30 minutes of shopping was all Dr. John Crockarell Jr., a Campbell Clinic orthopaedic I could stand.” surgeon who specializes in total joint replacement, has Anti-inflammatory drugs helped Rejeanna deal with successfully performed the surgery on ten Mid-South the pain for years, until she was hospitalized in 2003 for patients during the past 18 months. Dr. Crockarell is the high blood pressure. “When I had to stop taking the only Mid-South physician trained in the two-incision medication, I realized that drugs had been covering up technique for hip replacement surgery. pain that was getting progressively worse,” she said. “The two-incision method offers definite advantages Like many patients who’ve been told their arthritic over traditional hip replacement surgery for patients who joints will one day need to be replaced, Rejeanna had are good candidates for the technique,” Dr. Crockarell decided to delay the surgery as long as possible. “I kept said. “There is less surgical trauma, and for most patients debating with myself,” she said. “I wanted to wait, but I that means less pain and a shorter recovery period.” also was tired of missing out on so much. I just felt like Two of Dr. Crockarell’s patients who have had hip my life was on hold.” replacement surgery using the two-incision method are At 46, she worried that she would need a second Rejeanna Buchanan of Germantown and Paul Tubinis of surgery in the future, since replacement joints typically Collierville. Both patients are younger than the average last only 10 to 15 years. And she dreaded the long hip replacement patient and lead busy, active lives.

LIVING WITH PAIN EVERYDAY Rejeanna Buchanan was in her mid-40s when she began seriously considering having hip replacement surgery. Diagnosed with osteoarthritis 10 years earlier, she found the list of activities that caused pain in her hips growing longer each year. She had trouble doing everyday things, like climbing stairs, bending over to pick up a spoon dropped while cooking dinner, and walking from her downtown office a couple of blocks

Rejeanna Buchanan with Dr. John Crockarell Jr.

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S UCCESS S TORY

recovery time associated with joint replacement surgery undergone surgery. He sought information on the in the past. An accountant with Pittco Management in Internet. While watching a program on a public televi- Memphis, she didn’t want to take six months off from sion station, he heard about the two-incision technique work. for hip replacement surgery. “A faster recovery time was very important to me,”

DIMINISHED QUALITY OF LIFE he said. “I have two sons, one in college, and I couldn’t Paul Tubinis, who turned 50 this year, is a lifelong afford to take three months off from work.” He athlete. He played baseball and basketball in high school contacted Dr. Crockarell and underwent a series of tests and college; as an adult, he was a runner, played tennis to determine if he met criteria required of all patients and golf, and participated in other active sports. Then who have the two-incision surgery. Relevant criteria years of wear on his joints caught up with him. include medical history, weight, bone structure, health “I developed an arthritic hip, and moving it became status, and other factors. painful,” he said. “When I went to Tiger football games, BACK ON THEIR FEET I had trouble climbing the steps in the stadium. I had to Rejeanna Buchanan underwent surgery in May 2004. quit running. Driving was difficult. I developed a limp, In replacing Rejeanna Buchanan’s arthritic right hip, like those guys in the old Westerns. So it wasn’t just that Dr. Crockarell made a two-inch incision near the top of I couldn’t be the athlete I once was. My quality of life her thigh and a second two-inch incision on the back in general was less.” of the thigh. He then inserted an uncemented implant, Like many of today’s adults who actively seek to learn which bonded directly to Rejeanna’s bone to restore the more about their health, Paul began to read about hip motion of the replaced joint. replacement surgery and talk with people who had

HIP REPLACEMENT FACTS AND FIGURES

• First performed in 1960, hip replacement surgery is • The average age of a hip replacement patient is 68 one of the greatest surgical advances in the last century. years, and the average length of stay in the hospital is Approximately 160,000 total hip replacement surgeries five days. are now performed annually. • The average age of men undergoing total hip • The most common diagnosis for hip replacement replacement surgery is 65 years; the average age of patients is osteoarthritis and related disorders. women is 69 years. • The majority of total hip replacement surgeries — 65.9 percent of them — are performed on people age Source: DePuy Orthopaedics 65 and older.

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(l-r) Dr. Crockarell; patient Paul Tubinis with Cory Scates, athletic trainer at Campbell Clinic

Rejeanna’s recovery was not as rapid as some patients ENJOYING HAPPIER DAYS because the top of her thighbone developed a crack as Today Rejeanna Buchanan feels no pain in her new the replacement joint was being fitted into the bone. right hip. She’s off all pain medication. And she’s back Still, she was back at work in eight weeks. at her local Target store on Dollar Days, shopping as After his surgery on July 1, 2004, Paul Tubinis spent long as her bank account will allow instead of as long as two nights in the hospital. “But they had me up and her hips hold out. “My husband says the biggest differ- walking around with a walker on the day of ence is that I’m laughing a lot more,” she said. the operation,” he said. “I’m not saying that “I’ve got my life back.” it wasn’t painful, but I was just amazed that Six months after his surgery, Paul Tubinis says I was home on the third day after what his life has changed — in most cases, for the better. certainly qualifies as major surgery.” “I can’t run, but I’m playing golf again,” he said. A salesman who works out of his home “I’m watching my diet, and I’m able to do more office, Paul said he was making phone calls repetitions in my exercise routine than I could and using his computer the day he returned prior to surgery. I feel great. It’s just a miracle.” home from the hospital. “A physical therapist © Zimmer, Inc. The only drawback Mr. Tubinis has found is came to my home for five sessions, and I was that his new titanium hip sets off metal detectors in air- able to get out of the bed by myself on the tenth day,” ports. “Even though I have a card to show that the metal he said. “At the end of four weeks, when I visited is in my hip, I still get stopped every time,” he said. Dr. Crockarell’s office, I was able to walk out without “But I figure that’s a small price to pay for something using my walker.” that’s made such a positive change in my quality of life.”

BENEFITS, TWO-INCISION METHOD

• Less tissue trauma. Traditional hip replacement • Reduced blood loss. As a result, there’s less of a surgery requires making an incision of up to 12 inches. need for pre-surgery donation. With the new technique, the two incisions are each • Quicker return to daily activities about two inches long. • Criteria for patient qualification for the two- • Faster and less painful rehabilitation incision method include medical history, weight, • Smaller scars bone structure, health status, and other factors. • Shorter hospital stay. One to two days is typical, although some patients are able to go home in less than Source: Zimmer, Inc. 24 hours and some must remain in the hospital longer.

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C AMPBELL F OUNDATION G IFTS

Generous gift from Pfizer supports residency joint rotation program

Pfizer, the world’s largest research-based pharma- In 2004, Pfizer invested more than $7.7 billion in ceutical company, has demonstrated its commitment to research and development in 18 therapeutic areas, advancing medical research, innovation, and education including osteoarthritis. Pfizer developed and markets with a $100,000 gift to The Campbell Foundation. several leading medications used in the treatment of Pfizer’s gift to the Foundation will sponsor the rheumatoid arthritis and osteoarthritis. Total Joint Rotation of the Campbell Clinic-University “The Campbell Foundation’s mission is very similar of Tennessee Orthopaedic Residency Program. to our own,” said Michelle Rhea, District Manager of The gift will help underwrite the cost of Pain Rheumatology & Orthopaedics for Pfizer, educating 24 Campbell Clinic residents in Inc. “As a research-based health care company, the subspecialty area of joint replacement. In Pfizer strives to discover and develop new, recognition of the gift, the residency sequence innovative, value-added products that improve the will be named the Pfizer Total Joint Rotation. quality of life of people around the world. Without a Dr. Terry Canale, President of The Campbell doubt, Campbell Clinic is synonymous with innovation Foundation, said, “This gift demonstrates that Pfizer and global leadership in the field of orthopaedics. This recognizes the vital role highly-trained physicians play grant serves to mutually advance both our missions.” in the health care continuum. We look forward to The Campbell Clinic-University of Tennessee Ortho- working with Pfizer to take orthopaedic education to paedic Residency Program enables aspiring orthopaedic new levels of excellence while offering our patients surgeons to develop and refine their clinical, surgical, and hope for better, more active lives.” research skills. The accredited, five-year program has a

(l-r) Jack Blair, Chairman, Board of Trustees, The Campbell Foundation with Michelle Rhea, District Manager of Pain Rheumatology & Orthopaedics for Pfizer, Inc., and Dr. Terry Canale, Campbell Foundation President

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total of 40 full-time residents and ranks in the top eight percent of orthopaedic residency programs in the nation. More than 400 medical school graduates vie for the eight positions open each year. Residents in the program participate in the total joint rotation in their second, fourth, and fifth years. During each rotation, residents spend approximately 50 “AS A RESEARCH-BASED percent of their time in clinical activities and 50 percent in surgical duties, a HEALTH CARE COMPANY, practice that allows them to experience continuity of patient care from initial PFIZER STRIVES TO exam and evaluation, through surgical or non-surgical treatment and post- operative rehabilitation. DISCOVER AND DEVELOP During the total joint rotation, residents are instructed and mentored by NEW, INNOVATIVE, faculty members from the Campbell Clinic staff who have interest and training VALUE-ADDED PRODUCTS in the subspecialty of total joint replacement. Physicians who serve on the total joint rotation faculty include Dr. Andrew Crenshaw, Dr. John Crockarell, THAT IMPROVE THE Dr. James Guyton, Dr. James Harkess, and Dr. David LaVelle. QUALITY OF LIFE OF The residency program benefits significantly from monthly Journal Club PEOPLE AROUND THE meetings during which the teaching staff and residents review and discuss WORLD articles from the Journal of Bone and Joint Surgery and subspecialty journals. .” Dr. John Crockarell plans to start a Total Joint Journal Club using articles — Michelle Rhea, District Manager of

from the Journal of Arthoroplasty for discussion. The Pfizer gift will help Gift Pain Rheumatology & Orthopaedics for provide each resident with an individual subscription to the Journal of Pfizer, Inc. Arthroplasty. A number of major books and electronic resources will also be added to the Total Joint Library, including the Orthopaedic Knowledge Update series from the American Association of Orthopaedic Surgeons. In addition, planning has begun to launch a Total Joint Lecture Series. The series will bring a leading clinician-scientist to Memphis annually for two days of discussions and lectures with residents, Campbell Clinic staff, and the public.

“The opportunity to spend one-on-one time with Campbell Clinic staff in rotations is the best part of our residency. This quality time with gifted physicians and educators allows us a more personal level of interaction and challenges us to become better physicians and surgeons.”

— Dr. Kaveh Sajadi, Campbell Clinic resident Pfizer

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C AMPBELL F OUNDATION B OARD OF T RUSTEES

Jack R. Blair, S. Terry James H. Robert H. James H. Frederick M. Azar, Robert A. Allen S. James W. Buzzy Chairman Canale, M.D., Beaty, M.D., Miller, M.D., Calandruccio, M.D., M.D., Director, Compton Edmonson, M.D. Harkess, M.D. Hussey President Chief Staff Officer Secretary Treasurer Resident Education

NEW BOARD MEMBERS

AN OUTSTANDING TEAM OF Joseph Orgill III and Bernice H.“ Buzzy” Hussey, two Memphis business leaders who have both earned DISTINGUISHED PHYSICIANS, BUSINESS a reputation for creative thinking, smart business practices, and leadership in numerous community EXECUTIVES AND COMMUNITY , activities, have been named members of the Board LEADERS GUIDES THE CAMPBELL of Trustees of The Campbell Foundation.

FOUNDATION. EACH BOARD MEMBER J OSEPH O RGILL III Joe Orgill recently stepped down as Chairman of CONTRIBUTES INSIGHT AND VISION the Board of Orgill, Inc., the world’s largest indepen- dent hardware distributor. He represented the fifth THAT ARE VALUABLE AS THE generation of his family to direct the oldest business in Memphis still owned by the founding family. He FOUNDATION WORKS TO REALIZE ITS continues to serve as a director of the company. JOSEPH ORGILL III MISSION OF IMPROVING THE QUALITY A graduate of Yale University, Mr. Orgill is chair- man of Rock Island Corporation and a director of OF LIFE FOR PRESENT AND FUTURE The Mallory Group, both based in Memphis. He has served as a director on the boards of First Tennessee GENERATIONS. National Corporation, Commerce Title Guaranty Company, and Parts, Inc, as well as other companies. In 1998, Orgill was elected to membership in The Society of Entrepreneurs, an organization that recognizes MidSouth leaders who exhibit personal business achievement, self direction, personal integrity, determination, creativity, and the ability to transform a vision into a dynamic business achievement.

THE WILLIS CAMPBELL SOCIETY GALA, NOVEMBER 2004

(l-r) Campbell Fellowship alumni Drs. Rocco Calandruccio ‘54, Ken Moore ‘75, and Bob Tooms ‘64; New Campbell Clinic physicians Drs. Patrick Curlee ‘00, Susan Ishikawa ‘99, Francis Camillo ‘02 and Raymond Giardocki; Dr. Arsen Manugian ‘78, and his wife, Liz.

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Mark T. Joseph John H. Edward W. E. Greer W. Reid Rita T. Robert E. William C. Phillip E. Jobe, M.D. Orgill III Pontius Reed, M.D. Richardson, M.D. Sanders Sparks Tooms, M.D. Warner, M.D. Wright, M.D.

Mr. Orgill has helped improve the quality With imagination and style, Ms. Hussey created of life for area residents by serving as chairman a business that consumers frequently turn to for of the Advisory Committee, Baptist Memorial advice and inspiration as well as gifts. She has Hospital; a member of the Shelby County Hosp- been recognized for supporting many local and ital Authority; general campaign chairman and regional artists and artisans, exposing their works President, United Way of Greater Memphis; to a wider audience through her retail store. co-chairman of the Development Board of the Ms. Hussey has also demonstrated a strong Church Health Center; and trustee, Memphis commitment to philanthropy and civic interests. Speech and Hearing Clinic. She is a former chairman of the Board of His contributions to education and the arts Directors of Dixon Gallery and Gardens and has include leading the LeMoyne Owen College served as president of the Children’s Foundation Annual Fund Drive, serving on the Rhodes College of Memphis. She has also served on the Boards board of trustees, and serving on the Dean’s Advi- of Memphis Botanic Garden, LeMoyne Owen BUZZY HUSSEY sory Committee of the University of Memphis College, the Children’s Museum of Memphis, School of Business. He is a current trustee the Memphis Symphony League, Junior League of The Dixon Gallery and Gardens and serves as of Memphis, and the Thomas W. Briggs Founda- chairman of the Hugo Dixon Foundation. tion. She is an elder at Idlewild Presbyterian Church. B UZZY H USSEY A graduate of the University of Mississippi, Buzzy Hussey has also been recognized with Ms. Hussey serves on the University of Mississippi membership in The Society of Entrepreneurs Foundation Board and the Ole Miss Women’s for successfully building the company she owns, Council for Philanthropy. She has been inducted Babcock Gifts, into one of the most popular into the University of Mississippi Alumni Hall of and prestigious retail shops in the Mid-South. Fame.

Clinic physicians Drs. Patrick Curlee ‘00, Susan Ishikawa ‘99, Francis Camillo ‘02 and Raymond Giardocki; Dr. Arsen Manugian ‘78, and his wife, Liz.

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UT-CAMPBELL C LINIC D EPARTMENT OF O RTHOPAEDIC S URGERY Researcher relishes days spent chasing answers about arthritis

What Karen Hasty knows about arthritis could cartilage early in the disease and develop the possibility fill not just a book, but a small library of books. The of cartilage regeneration, if it has broken down. Those problem, Dr. Hasty says, is that for everything she are just a few; there are a lot more.” knows about arthritis, there’s far more that she doesn’t. “That is what it’s like to be a research scientist,” WHAT HAS CHANGED MOST DURING THE said Hasty, chief researcher for the UT-Campbell Clinic THREE DECADES YOU’VE BEEN A SCIENTIFIC Department of Orthopaedic Surgery. “Every answer RESEARCHER? raises another question. It’s not frustrating, it’s “Scientific advances and new technology developed fascinating. I’ve been doing research for 30 years, and over the course of my career have been just phenomenal. I still think it’s a wonderful way to spend your life.” We now know the sequence of every gene Since Hasty is accustomed to questions, we asked in the human body, and you can buy some about her work and the scientific research 20,000-plus genes on a microchip to profession. Here are her answers: study in the lab. This year our department was able to purchase a WHAT ARE SOME OF THE QUESTIONS MicroCT, an amazing machine that YOU ARE STUDYING IN REGARD TO will let us label cells, inject them, ARTHRITIS? and watch where they go. There “My work is concerned primarily with understand- are more than I can mention, ing what is happening on the cellular level as arthritis but I feel like we’re just at develops. We have been using a machine in the lab to the beginning of a put physical stresses on cartilage and asking, how great era for sci- does mechanical stress affect cellular behavior? entific discovery. We ask, how do young cartilage cells “Another big respond to those stresses in comparison change is that with old cartilage cells? We’re looking at research science the effects of certain growth factors. today is more We want to prevent the breakdown of

2004 DEPARTMENT MILESTONES

NEW TECHNOLOGY human diseases. Developed by level of expression of 47,000 gene • A $437,800 grant from the researchers at Oak Ridge National transcripts that examine tissue from National Institutes of Health Laboratory, the MicroCT is the first knee joints needing replacement. of its kind to also have a single enabled the UT-Campbell Clinic NEW RESEARCH GRANTS photon emission computer-aided Department of Orthopaedic Surgery AND CONTRACTS tomography function that will allow to install and give researchers access • Dr. Weichuan Gu received tracking of labeled cells, growth to a high-resolution Imtek Micro NIH/NIAMA funding in the factors, and antibodies. Computer Aided Tomography amount of $910,000 (total direct System (MicroCT). The machine • First screening of osteoarthritic costs) for a grant titled “Mutation will allow evaluation of bone forma- cartilage genes using DNA array screening of skeletal disease, mouse tion and skeletal abnormalities in microchip analysis. This break- model.” Dr. Gu will be Principal animal models that are relevant to through technology will screen the Investigator for the grant.

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multi-disciplinary. You can’t be just a chemist, or a DO YOU THINK THE MEMPHIS MUSCULO- molecular biologist, or a bioengineer. You’ve really got SKELETAL RESEARCH INSTITUTE, WHICH WILL to encompass all those fields. The questions we’re asking EMPHASIZE INTERDISCIPLINARY COLLABORA- are more complex, and you can’t know everything, so TION, WOULD ADVANCE RESEARCH LOCALLY? you work with other scientists who are specialists in the “Oh, I’m a big supporter of the MMRI. Nobody other areas. We used to work in boxes; now we are does science in a vacuum. Scientists write and talk about putting the boxes together in a systems approach.” their work, others study their reports, then we apply their knowledge to what we are doing. I know my work HOW DOES THAT APPLY TO YOUR has benefited from working with the researchers in RESEARCH ON ARTHRITIS? connective tissue and bioengineering at the University “I started out as a cell biologist, growing cells in of Tennessee and the University of Memphis. But right a Petri dish. Then the research I became involved in now, we are scattered in many different places. There’s required that I evolve into a biochemist, then a something called the Coffee Pot Phenomena: People molecular biologist. Now what I am doing means I stand around and talk, and they exchange ideas. have to pick up some parts of the orthopaedic approach Working under one roof at the MMRI, with daily as well as tissue engineering. I do not know all these interactions, would feed our work.” fields as well as someone who is a specialist. I really think the era of the individual scientist is over. The WHAT’S THE MOST INTERESTING PROJECT breakthroughs are beginning to come from larger, YOU’VE EVER WORKED ON? interdisciplinary groups.” “What I’m working on right now. It’s always that way — my current project absorbs me; the next experi- ment is the most exciting. I can’t believe I get paid to do something I love so much.”

• Five grants totaling $774,937 PUBLICATIONS • Papers were presented at meetings (direct costs) were renewed for • Members of the Department had of the Combined Societies of research being conducted by Dr. eleven papers published in peer- Orthopaedic Research in Banff; the Karen Hasty. Grant sources are NIH reviewed journals and three addi- Asia-Pacific League of Associated and the Veteran’s Administration. tional papers reviewed in the press. Rheumatology; American Society for • Dr. Richard Smith was awarded Bone and Mineral Research; Tissue two contracts by Smith & Nephew NATIONAL & INTERNATIONAL Engineering Society International; for “Studies of Platelet Concen- PRESENTATIONS Society for Biomaterials and Seventh tration by Filtration” and “Phase II • In 2004, the Department had six World Biomaterials Congress; and Evaluation of Cellular Interactions abstracts accepted for presentation at The Limb Lengthening and of Polyethylene and Its Wear the Orthopaedic Research Society. Reconstruction Society: ASAMI- Products.” The Department has had seven North America. abstracts accepted for 2005.

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A LUMNI N EWS OTHER NEWS

Dr. Lee Milford ‘53, retired Campbell Clinic surgeon, has remained very active in his retire- ment. He has published his memoirs, Remembrances of a Hand Surgeon. Dr. Milford recently pre- sented the Campbell Foundation staff a grandfather clock he had assembled and finished in honor of the staff’s years of service and dedication.

Dr. William A. Sims ‘66 is serving on the board of trustees of the Orthopaedic Research and Education Foundation (OREF).

Dr. Susan Ishikawa at Camp Babylon Three Campbell fellowship alumni return, join Clinic’s physician staff

Days and nights have been long, busy, and Working in such conditions, Dr. Ishikawa said, demanding for Dr. Susan Ishikawa ‘99 recently as she “makes you realize how much we take for granted, sets up office, meets new patients, schedules surgeries, professionally and personally. It makes you grateful for and assumes other responsibilities as a new physician what you have.” with Campbell Clinic. A native of Hawaii, she received an undergraduate The hectic pace, Dr. Ishikawa said, is something degree in biology from Harvard University and attended she’s prepared for. Her last job was good training. Jefferson Medical College in Philadelphia on an Army In August 2004, Dr. Ishikawa returned from seven Health Professions Scholarship. Her tour of duty in months’ duty in Iraq, serving as the orthopaedic surgeon Iraq was the final assignment to complete her military on the surgical team stationed at Camp Babylon near obligation. the city of Al Hillah, south of Baghdad. Dr. Ishikawa, whose subspecialty is foot and ankle, In Iraq, Dr. Ishikawa treated numerous blast injuries. served a fellowship at Campbell Clinic in 1999. She said Her patients included international soldiers, Iraqi soldiers that Campbell Clinic’s reputation, the expertise of staff and citizens, civilian contractors — and enemy combat- physicians, opportunities to teach and do research, and ants, as well. “If we hurt them, we are obligated to help the friendliness of the patients and people she’d met them,” Dr. Ishikawa said. during her year in Memphis were all factors in her Despite months of duty spent sleeping on an air decision to join the Campbell Clinic physician staff. mattress, living without indoor plumbing, and eating “Foot and ankle is one of the younger subspecial- military rations, Dr. Ishikawa isn’t complaining. ties,” she said, “and I believe there will be a lot of new “We had it better than many military personnel,” discoveries that will benefit patients in the years just she said. “We weren’t in the most dangerous area of ahead. I’m excited about being part of the progress.” Iraq. Although we were operating in tents, they were air conditioned. We had limited equipment, but it was adequate.”

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Drs. Frank B. Kelly, Jr. ‘78 in 2004, but spent February Board of Orthopaedic and Frederick M. Azar ‘94 2005 in Bhutan, a country Surgery (ABOS), the serve onthe board of direc- in the eastern Himalayas, organization which estab- tors of the American volunteering with Ortho- lishes educational standards Academy of Orthopaedic paedics Overseas, a non- for orthopaedic residents Surgeons (AAOS). profit and non-sectarian and evaluates the initial and volunteer program dedicated continuing qualifications and Dr. Walter Shelton ‘79 to improving the availability knowledge of orthopaedic was elected Second Vice and quality of health care in surgeons. President of the Arthro- developing countries scopy Association of North through training and Dr. William C. Warner ‘88 America (AANA). Dr. education. has been elected Chief of Shelton is slated to become Staff of LeBonheur Child- President of AANA in May Dr. James H. Beaty ‘81 ren’s Medical Center in 2006. Campbell Clinic Chief of Memphis. Staff, completed a two-year Dr. Kenneth L. Moore ‘75 term (2002-2003) as retired from active practice President of the American

Dr. Lee Milford ‘53

Two other physicians who completed fellowships at A native of New York state, Dr. Camillo is a graduate Campbell Clinic have also joined the Clinic as staff of the University of Notre Dame. He attended New physicians. They are spine surgeons Dr. Patrick M. York Medical College, receiving his degree in 1992. Curlee and Dr. Francis X. Camillo. He completed an internship in general surgery at Dr. Patrick Curlee ‘00, a spine specialist, joined Loyola University Medical Center in Maywood, Illinois, the Campbell Clinic staff in August 2004. A native of and a residency in general surgery at New York Medical North Carolina, he received an undergraduate degree College in Valhalla. Dr. Camillo completed a residency from the University of North Carolina-Charlotte and in orthopaedic surgery and served as orthopaedic house graduated with honors from East Carolina University physician at New York Medical College. Before joining School of Medicine. Campbell Clinic, he was in practice with Rivertown Dr. Curlee served a general surgical internship and Orthopaedic Group in Ardsley, New York. an orthopaedic surgical residency at the University of Miami Memorial Hospital in Miami. His post-graduate training included a spine fellowship at Campbell Clinic in 1999-2000. He previously practiced at Carolina Sports Medicine in Wilmington, North Carolina. A Board-certified orthopaedic surgeon, Dr. Curlee is a fellow of the American Academy of D ON’ T M ISS I T ! Orthopaedic Surgery and a member of the American Medical Association. 2006 Campbell Club Triennial We want to hear your news! Dr. Francis Camillo ‘02 is also a spine Meeting, Destin, Florida, Please e-mail or call specialist. He became a Campbell Clinic staff June 29 - July 2 Jennifer Strain, physician in September 2004, having previously Make plans now to meet on [email protected] completed his fellowship at Campbell Clinic in the beach! (901) 759-5490 2001-2002.

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THANKING OUR DONORS

Patrons $5,000 – $9,999 Dr. & Mrs. Robert H. Miller Dr. & Mrs. Frederick M. Azar Dr. & Mrs. Edward A. Perez The Willis C. Campbell Baptist Memorial Health Care Dr. & Mrs. Barry B. Phillips Society Dr. & Mrs. James H. Beaty Dr. & Mrs. Robert M. Pickering Philanthropists $100,000 and above Jack & Kathleen Blair Mr. & Mrs. W. Reid Sanders DePuy Orthopaedics, Inc. Dr. & Mrs. James H. Calandruccio Dr. & Mrs. Willard R. Sparks Memphis Biotech Foundation Dr. & Mrs. Peter G. Carnesale Dr. & Mrs. Marcus J. Stewart Pfizer, Inc. Dr. Kevin B. Cleveland Dr. & Mrs. E. Greer Richardson Smith & Nephew Orthopaedics Dr. & Mrs. Andrew Crenshaw, Jr. Dr. & Mrs. Robert E. Tooms Dr. & Mrs. John R. Crockarell, Jr. Drs. William & Susan Warner Fellows $50,000 - $99,999 Drs. Gregory D. & Donna Dabov Dr. A. Paige Whittle Smith & Nephew Endoscopy Dr. & Mrs. Jeffrey A. Dlabach Dr. & Mrs. Keith D. Williams Dr. & Mrs. Allen S. Edmonson Dr. & Mrs. George W. Wood, II Benefactors $25,000 – $49,999 Dr. & Mrs. Kendall Ethridge Dr. & Mrs. Phillip E. Wright, II Campbell Clinic First Tennessee Bank Campbell Club Dr. & Mrs. Barney L. Freeman, III The President’s BREG Dr. & Mrs. James W. Harkess Society Drs. Richard & Anne Hayes Senior Members $2,500 - $4,999 Sustainers $10,000 – $24,999 Dr. & Mrs. Robert K. Heck, Jr. Lucie M. King, M.D. Dr. & Mrs. S. Terry Canale Dr. & Mrs. Royce Hobby Dr. & Mrs. Arsen H. Manugian Robert and Janice Compton Dr. & Mrs. Charles Hubbard Dr. & Mrs. Marc J. Mihalko Dr. & Mrs. James L. Guyton Mr. & Mrs. J.R. Hyde, III Dr. & Mrs. Ashley L. Park Mr. & Mrs. James E. McGehee, Jr. Dr. & Mrs. Mark T. Jobe Dr. & Mrs. Carlos E. Rivera Dr. & Mrs. G. Andrew Murphy Dr. & Mrs. David G. LaVelle Mr. & Mrs. Frank M. Norfleet Dr. & Mrs. Santos F. Martinez Synthes

Friends Society Bronze to $100-$249 Supporters Gold $500 - $999 Ms. Leah D. Box Mr. & Mrs. Joe Arwood Kendall Blake, Jr., M.D. William and Mary Brown Mr. & Mrs. Dan Bowden Dr. & Mrs. Neal G. Clement Mr. & Mrs. John C. Cameron Ms. Harriet J. Brooks Mrs. Eleanor A. Crawford Mr. & Mrs. David Compton Ms. Secondina B. Galtelli Jeffrey C. Davis, M.D. Mr. Leo W. Cumbelich Ms. Helen A. Garner Dr. & Mrs. James R. Dinn Ms. Lilli Dabov Ms. Merian J. Gibson Dr. & Mrs. William Gramig, III Mr. & Mrs. Tyke Darlington Ms. Joyce Hearnsberger Dr. & Mrs. Basil M. Griffin Ms. Suzette Dillon Everett & Gaylann Hicks Dr. & Mrs. Russell C. Linton Mr. Kenneth Hardin Ms. Mary Hight Dr. & Mrs. Robert W. Moore Dr. & Mrs. James H. Hardy, III Dr. & Mrs. Otis E. James Dr. & Mrs. James D. Murphy Robert & Carmen Holmes Mr. & Mrs. H.J. Langenfelder Dr. & Mrs. Terry R. Noonan Mr. & Mrs. L. R. Jalenak, Jr. Ms. Patricia H. Litten Speed Medical Dr. & Mrs. Jeffrey S. Kaplan Ms. Gail Milnor Dr. & Mrs. James C. Slater Mrs. Frances C. Kauffman Ms. Jane Pardue-Charles Mr. Milton L. Knowlton SHRM - Memphis Silver $250-$499 Allen & Mildred Lee Mrs. Loretta Scott Dr. & Mrs. Gary L. Becker Col. & Mrs. George W. McHenry Mr. & Mrs. Bruce Taylor Mr. & Mrs. John J. Colcolough Mr. & Mrs. Les Morgan Frank & Jeanne Jemison Paul D. Parsons, M.D. Gifts-in-Kind Mr. & Mrs. Henry Pitts Mr. Brett Kyle DePuy Orthopaedics, Inc. Dr. & Mrs. J. Bryan Smalley Dr. & Mrs. Ronald Lederman Geri Meltzer Designs Dr. & Mrs. Bruce R. Stivers Dr. Robert McGinley P & G Pharmaceuticals Kathleen A. Robertson, M.D. Dr. & Mrs. Thomas E. Strong Schilling Enterprises Surgical Technologies Dr. & Mrs. Owen B. Tabor Dr. & Mrs. H. Jack Williams The Columbia Surgery Group Mr. & Mrs. John M. Williams Ms. Janet Zimmerman

WE ARE GRATEFUL FOR THE MANY INDIVIDUALS AND ORGANIZATIONS THAT HAVE SUPPORTED THE CAMPBELL FOUNDATION DURING THE LAST YEAR. THE GENEROSITY OF THOSE LISTED HAS ENHANCED OUR EFFORTS TO ADVANCE MUSCULOSKELETAL RESEARCH, EDUCATION, AND PATIENT CARE. 18

2004 SUPPORTERS OF T HE C AMPBELL FOUNDATION

Members $1,000 - $2,499 David Kuester, M.D. Benefactors Circle Mr. Ryan Ables Dr. & Mrs. Rickey L. Lents Endowment Funds Dr. & Mrs. Gregory M. Behm Dr. & Mrs. Robert L. Liljeberg S.T. Canale, M.D. Research Dr. & Mrs. Kenneth Bell Dr. & Mrs. John J. Lochemes Endowment Boehringer Ingelheim Drs. Steven & Heidi Martin EBI Study Fund Dr. & Mrs. R. Tyler Boone Midsouth Surgical Supply General Research Fund Dr. & Mrs. William L. Bourland Dr. & Mrs. Kenneth L. Moore Humana Research Fund Dr. & Mrs. James T. Canedy OREF Human Performance Lab Fund Dr. & Mrs. Charles O. Carothers Kyle L. Palmer, M.D. Alvin J. Ingram, M.D. Pediatric Dr. & Mrs. John M. Chandler Parker Medical, Inc. Orthopaedic Lectureship James L. Chappuis, M.D. Glen & Darlene Paul John S. Jenkins Memorial Fund Dr. & Mrs. R. Michael Cobb Dr. & Mrs. John D. Pigott Scoliosis Research Fund Dr. & Mrs. Michael Coscia Mr. & Mrs. John H. Pontius Hugh Smith Research Fund John Crates, M.D. Dr. & Mrs. Edward W. Reed J. Spencer Speed Scholarship Fund Dr. & Mrs. Eslick E. Daniel Dr. & Mrs. Richard S. Riggins F.O. Wright Lecture Fund Dr. & Mrs. Ken P. DePersio Cary & Wendy Rotter Dr. & Mrs. M. Craig Ferrell Ms. Jane Allen Sharpe Campbell Legacy Gerber Taylor Associates, Inc. Scott E. Strasburger, M.D. Society Planned Gifts Michael L. Gernant, M.D. Dr. & Mrs. Kenneth Stephenson Dale E. Fox, M.D. Dr. & Mrs. Stewart J. Harley Dr. & Mrs. Paul A. Thomas Marvin M. Gibson, M.D. John T. Hocker, M.D. Ethan O. Todd, M.D. Mrs. Peggy Metz Dr. & Mrs. Roy W. Holand Dr. & Mrs. Kenneth L. Vandervoort E. Michael Holt, M.D. Mr. & Mrs. John M. Vines Brian C. Howard, M.D. Dennis & Karen Watson Inman Construction Joseph A. Wieck, M.D. Dr. & Mrs. E. Jeff Justis Dr. & Mrs. Alan B. Wood

Memorial Gifts Rocco Calandruccio, M.D. Robert Miller, M.D. Gifts were made in memory of: Dr. & Mrs. Owen Tabor Lisa Calcolough Thomas H. Blake, Sr., M.D. S. Terry Canale, M.D. Bruce Taylor Kendall Blake, M.D. Wendy Rotter Kenneth L. Moore, M.D. Henry Galtelli Janet Zimmerman The Columbia Surgery Group Secondina Galtelli Peter G. Carnesale, M.D. E. Greer Richardson, M.D. Louise Navarro, M.D. Mary Langenfelder Mary Langenfelder Kenneth L. Moore, M.D. Meredith Compton Ronald Lederman Doris Lake David Compton Marcus J. Stewart, M.D. Patsy Mayer Andrew H. Crenshaw, M.D. William L. Bourland, M.D. Joe Pipkin Jane Pardue-Charles Robert E. Tooms, M.D. S. Terry Canale, M.D. Christopher L. Hendrix, D.P.M. Burton H. Milnor Barney L. Freeman, II, M.D. Robert & Carmen Holmes John M. Vines Virginia Galyon Santos F. Martinez, M.D. SHRM - Memphis Dot Pickering Mr. & Mrs. Allen Lee, Jr. Campbell Clinic John B. Peyton Ann Pratt Robert E. Tooms, M.D. Fred P. Sage, M.D F OR M ORE I NFORMATION Brian C. Howard, M.D.

Honoraria Please contact: Wendy T. Rotter, Executive Director of Development, Gifts were made in honor of: 1400 S. Germantown Rd., Germantown, TN 38138 James H. Beaty, M.D. (901) 759-5490 • [email protected] William A. Brown

YEAR. THE GENEROSITY OF THOSE LISTED HAS ENHANCED OUR EFFORTS TO ADVANCE MUSCULOSKELETAL RESEARCH, EDUCATION, AND PATIENT CARE. 19

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