GENES BELONGING TO THE APOPTOTIC INTRINSIC PATHWAY

DIFFERENTIALLY EXPRESSED: ProbeSet ID Name Gene Symbol Synonym logFC adj.P.Val 210538_s_at baculoviral IAP repeat-containing 3 BIRC3 AIP1, API2, CIAP2, HAIP1, HIAP1,3.072 MALT2,6.44E-07 MIHC, RNF49 204493_at BH3 interacting domain death agonist BID FP497, MGC15319, MGC423551.648 1.65E-05 211725_s_at BH3 interacting domain death agonist BID FP497, MGC15319, MGC423551.266 2.02E-05 204859_s_at apoptotic peptidase activating factor 1 APAF1 CED4, DKFZp781B1145 1.107 0.0009 208478_s_at BCL2-associated X BAX BCL2L4 -1.009 0.0005 211833_s_at BCL2-associated X protein BAX BCL2L4 -1.137 0.0002

NON-DIFFERENTIALLY EXPRESSED: ProbeSet ID Gene Name Gene Symbol Synonym logFC adj.P.Val 207181_s_at 7, -related cysteine peptidase CASP7 CMH-1, ICE-LAP3, MCH3 0.845 0.001 203089_s_at HtrA serine peptidase 2 HTRA2 OMI, PARK13, PRSS25 0.591 0.001 214056_at myeloid cell leukemia sequence 1 (BCL2-related) MCL1 BCL2L3, EAT, MCL1L, MCL1S,0.522 MGC104264,0.037 MGC1839, TM 200798_x_at myeloid cell leukemia sequence 1 (BCL2-related) MCL1 BCL2L3, EAT, MCL1L, MCL1S,0.340 MGC104264,0.020 MGC1839, TM 203728_at BCL2-antagonist/killer 1 BAK1 BAK, BAK-LIKE, BCL2L7, CDN1,0.272 MGC117255,0.068 MGC3887 204285_s_at phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 APR, NOXA 0.244 0.448 202076_at baculoviral IAP repeat-containing 2 BIRC2 API1, HIAP2, Hiap-2, MIHB, RNF48,0.213 cIAP10.095 205512_s_at apoptosis-inducing factor, -associated, 1 AIFM1 RP3-438D16.2, AIF, MGC111425,0.182 PDCD80.197 201066_at cytochrome c-1 CYC1 UQCR4 0.165 0.190 204286_s_at phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 APR, NOXA 0.161 0.540 211152_s_at HtrA serine peptidase 2 HTRA2 OMI, PARK13, PRSS25 0.142 0.244 211692_s_at BCL2 binding component 3 BBC3 JFY1, PUMA 0.109 0.392 200796_s_at myeloid cell leukemia sequence 1 (BCL2-related) MCL1 BCL2L3, EAT, MCL1L, MCL1S,-0.111 MGC104264,0.662 MGC1839, TM 219350_s_at diablo homolog (Drosophila) DIABLO DIABLO-S, FLJ10537, FLJ25049,-0.129 SMAC,0.280 SMAC3 210775_x_at caspase 9, apoptosis-related cysteine peptidase CASP9 RP11-265F14.3, APAF-3, APAF3,-0.180 CASPASE-9c,0.216 ICE-LAP6, MCH6 203984_s_at caspase 9, apoptosis-related cysteine peptidase CASP9 RP11-265F14.3, APAF-3, APAF3,-0.245 CASPASE-9c,0.146 ICE-LAP6, MCH6 202763_at caspase 3, apoptosis-related cysteine peptidase CASP3 CPP32, CPP32B, SCA-1 -0.295 0.062 211464_x_at caspase 6, apoptosis-related cysteine peptidase CASP6 MCH2 -0.345 0.033 200797_s_at myeloid cell leukemia sequence 1 (BCL2-related) MCL1 BCL2L3, EAT, MCL1L, MCL1S,-0.408 MGC104264,0.009 MGC1839, TM 206665_s_at BCL2-like 1 BCL2L1 BCL-XL/S, BCL2L, BCLX, Bcl-X,-0.454 DKFZp781P2092,0.055 bcl-xL, bcl-xS 212312_at BCL2-like 1 BCL2L1 BCL-XL/S, BCL2L, BCLX, Bcl-X,-0.463 DKFZp781P2092,0.007 bcl-xL, bcl-xS 1861_at BCL2-associated agonist of cell death BAD BBC2, BCL2L8 -0.465 0.014 209790_s_at caspase 6, apoptosis-related cysteine peptidase CASP6 MCH2 -0.537 0.031 209364_at BCL2-associated agonist of cell death BAD BBC2, BCL2L8 -0.540 0.005 215037_s_at BCL2-like 1 BCL2L1 BCL-XL/S, BCL2L, BCLX, Bcl-X,-0.671 DKFZp781P2092,0.016 bcl-xL, bcl-xS 213373_s_at caspase 8, apoptosis-related cysteine peptidase CASP8 ALPS2B, CAP4, FLICE, FLJ17672,-0.686 MACH,0.003 MCH5, MGC78473 207686_s_at caspase 8, apoptosis-related cysteine peptidase CASP8 ALPS2B, CAP4, FLICE, FLJ17672,-0.747 MACH,0.007 MCH5, MGC78473

BELOW FILTERING THRESHOLD: ProbeSet Intensity Value (log2 scale) ProbeSet ID Gene Name Gene Symbol Synonym T98G_A T98G_B 211553_x_at apoptotic peptidase activating factor 1 APAF1 CED4, DKFZp781B1145 5.48 5.29 211554_s_at apoptotic peptidase activating factor 1 APAF1 CED4, DKFZp781B1145 7.38 7.34 203684_s_at B-cell CLL/lymphoma 2 BCL2 Bcl-2 6.26 6.41 203685_at B-cell CLL/lymphoma 2 BCL2 Bcl-2 4.76 5.21 207004_at B-cell CLL/lymphoma 2 BCL2 Bcl-2 6.39 6.59 207005_s_at B-cell CLL/lymphoma 2 BCL2 Bcl-2 6.34 6.31 208536_s_at BCL2-like 11 (apoptosis facilitator) BCL2L11 BAM, BIM, BIM-alpha6, BIM-beta6, BIM-beta7, BOD,4.34 BimEL, BimL4.48 222343_at BCL2-like 11 (apoptosis facilitator) BCL2L11 BAM, BIM, BIM-alpha6, BIM-beta6, BIM-beta7, BOD,5.80 BimEL, BimL5.96 205780_at BCL2-interacting killer (apoptosis-inducing) BIK BIP1, BP4, NBK 5.66 5.60 214057_at myeloid cell leukemia sequence 1 (BCL2-related) MCL1 BCL2L3, EAT, MCL1L, MCL1S, MGC104264, MGC1839,6.41 TM 6.33 206536_s_at X-linked XIAP RP1-315G1.5, API3, BIRC4, ILP1, MIHA, XLP2 5.47 5.42 206537_at X-linked inhibitor of apoptosis XIAP RP1-315G1.5, API3, BIRC4, ILP1, MIHA, XLP2 5.11 5.32

ProbeSet Intensity Value (log2 scale) T98G_C U87MG_A U87MG_B U87MG_C 5.06 5.07 5.19 5.25 7.46 6.99 6.78 6.68 6.15 6.32 6.22 6.35 5.06 5.55 6.44 5.63 6.38 6.34 6.45 6.52 6.43 6.09 6.17 6.41 4.38 4.19 3.92 4.14 5.83 5.44 5.03 5.19 5.34 5.72 5.71 5.72 6.27 6.39 6.23 6.38 5.32 6.08 6.04 5.20 5.15 5.27 5.59 5.21 Gene symbol Fold difference (log2)* Gene name Function Localization ProbeSet ID P value GSTM3 6.81 glutathione S-transferase M3 (brain) Enzyme 202554_s_at 2.30E-08 GPX3 6.64 glutathione peroxidase 3 (plasma) Enzyme Extracellular space 201348_at 9.93E-09 GPX7 2.36 glutathione peroxidase 7 Enzyme Cytoplasm 213170_at 4.95E-07 GCLC 2.26 glutamate-cysteine ligase, catalytic subunit Enzyme Cytoplasm 202923_s_at 3.53E-06 MGST2 1.94 microsomal glutathione S-transferase 2 Enzyme Cytoplasm 204168_at 4.32E-06 GGT5 1.90 gamma-glutamyltransferase 5 Enzyme Plasma membrane 205582_s_at 3.66E-05 GCLM 1.35 glutamate-cysteine ligase, modifier subunit Enzyme Cytoplasm 203925_at 7.34E-05 GSR 0.86 glutathione reductase Enzyme Cytoplasm 205770_at 0.00023 GSTP1 0.75 glutathione S-transferase pi 1 Enzyme Cytoplasm 200824_at 0.000705 GSTT2 0.30 glutathione S-transferase theta 2 Enzyme Cytoplasm 205439_at 0.047785 GSTK1 -0.33 glutathione S-transferase kappa 1 Enzyme Cytoplasm 217751_at 0.039408 GSS -0.47 glutathione synthetase Enzyme Cytoplasm 201415_at 0.003796 GSTT1 -0.68 glutathione S-transferase theta 1 Enzyme Cytoplasm 203815_at 0.001472 GGTLC1 -0.75 gamma-glutamyltransferase light chain 1 Enzyme Unknown 211416_x_at 0.000402 GGT2 -0.90 gamma-glutamyltransferase 2 Enzyme Cytoplasm 215603_x_at 0.000248 GSTM2 -0.96 glutathione S-transferase M2 (muscle) Enzyme Cytoplasm 204418_x_at 0.000477 GGT1 -0.98 gamma-glutamyltransferase 1 Enzyme Cytoplasm 207131_x_at 9.58E-05 GSTM1 -1.11 glutathione S-transferase M1 Enzyme Cytoplasm 204550_x_at 0.000471 GSTO1 -1.13 glutathione S-transferase omega 1 Enzyme Cytoplasm 201470_at 3.06E-05 GSTZ1 -1.42 glutathione transferase zeta 1 Enzyme Cytoplasm 209531_at 0.000118 MGST3 -1.47 microsomal glutathione S-transferase 3 Enzyme Cytoplasm 201403_s_at 1.16E-05 GSTA4 -2.73 glutathione S-transferase A4 Enzyme Cytoplasm 202967_at 2.88E-05 Gene symbol Fold difference (log2)* Gene name ProbeSet ID P value SPP1 -5.05 secreted phosphoprotein 1 209875_s_at 6.98E-08 PRSS3 -4.05 protease, serine, 3 207463_x_at 9.43E-07 COL1A1 -3.90 collagen, type I, alpha 1 202310_s_at 5.32E-07 TNC -3.88 tenascin C 216005_at 7.67E-08 LTBP1 -3.82 latent transforming growth factor beta binding protein 1 202729_s_at 2.41E-07 WNT7B -3.23 wingless-type MMTV integration site family, member 7B 217681_at 1.30E-05 MMP16 -3.20 matrix metallopeptidase 16 (membrane-inserted) 207012_at 7.04E-05 COL15A1 -3.14 collagen, type XV, alpha 1 203477_at 1.26E-07 THBS2 -3.03 thrombospondin 2 203083_at 2.60E-07 ADAMTS5 -2.84 ADAM metallopeptidase with thrombospondin type 1 motif, 5 219935_at 0.000301 PRSS2 -2.50 protease, serine, 2 (trypsin 2) 205402_x_at 1.24E-06 VCAN -2.41 versican 204620_s_at 5.70E-06 MMP3 -2.36 matrix metallopeptidase 3 (stromelysin 1, progelatinase) 205828_at 0.000346 TFPI2 -2.29 tissue factor pathway inhibitor 2 209277_at 1.23E-06 LTBP2 -2.19 latent transforming growth factor beta binding protein 2 204682_at 2.33E-06 VEGFA -2.16 vascular endothelial growth factor A 211527_x_at 2.38E-06 MFAP4 -2.13 microfibrillar-associated protein 4 212713_at 1.58E-05 IL1B -1.90 interleukin 1, beta 39402_at 7.25E-05 COL8A1 -1.84 collagen, type VIII, alpha 1 214587_at 1.32E-05 APOH -1.72 apolipoprotein H (beta-2-glycoprotein I) 205216_s_at 4.39E-05 FBN1 -1.72 fibrillin 1 202765_s_at 0.000105 TNXB -1.41 tenascin XB 216333_x_at 0.000409 LAMC2 -1.39 laminin, gamma 2 202267_at 2.38E-05 COL4A6 -1.14 collagen, type IV, alpha 6 213992_at 0.000653 TIMP1 -0.89 TIMP metallopeptidase inhibitor 1 201666_at 0.000336 Gene symbol Fold difference (log2)* Gene name ProbeSet ID P value THBS1 7.88 thrombospondin 1 201109_s_at 2.30E-08 COL18A1 5.23 collagen, type XVIII, alpha 1 209081_s_at 7.51E-08 COL3A1 5.22 collagen, type III, alpha 1 215076_s_at 3.49E-06 COL4A1 4.95 collagen, type IV, alpha 1 211980_at 1.98E-06 POSTN 4.36 periostin, osteoblast specific factor 210809_s_at 4.00E-07 TGFB2 4.32 transforming growth factor, beta 2 209909_s_at 1.78E-07 FBLN1 4.01 fibulin 1 202995_s_at 1.96E-06 COL4A2 3.77 collagen, type IV, alpha 2 211964_at 1.78E-07 WNT5B 3.63 wingless-type MMTV integration site family, member 5B 221029_s_at 9.43E-07 TIMP3 3.42 TIMP metallopeptidase inhibitor 3 201147_s_at 4.31E-07 MMP13 3.27 matrix metallopeptidase 13 (collagenase 3) 205959_at 4.31E-07 CYR61 2.97 cysteine-rich, angiogenic inducer, 61 210764_s_at 1.86E-06 EFEMP1 2.87 EGF-containing fibulin-like extracellular matrix protein 1 201842_s_at 6.93E-07 MMP1 2.68 matrix metallopeptidase 1 (interstitial collagenase) 204475_at 1.77E-06 SCG2 2.28 secretogranin II (chromogranin C) 204035_at 3.61E-05 FST 2.21 follistatin 204948_s_at 0.000461 EDN1 2.15 endothelin 1 218995_s_at 1.33E-05 COL5A1 1.93 collagen, type V, alpha 1 212489_at 0.000166 CSF1 1.87 colony stimulating factor 1 (macrophage) 207082_at 5.68E-06 LAMB1 1.83 laminin, beta 1 201505_at 5.89E-05 MGP 1.79 matrix Gla protein 202291_s_at 0.000331 NRG1 1.77 neuregulin 1 208231_at 0.005987 COL7A1 1.72 collagen, type VII, alpha 1 217312_s_at 0.000755 LAMB3 1.61 laminin, beta 3 209270_at 8.68E-06 LAMA4 1.58 laminin, alpha 4 202202_s_at 2.99E-05 TIMP2 1.30 TIMP metallopeptidase inhibitor 2 203167_at 4.20E-05 HSPG2 1.30 heparan sulfate proteoglycan 2 201655_s_at 0.00012 COL5A2 1.26 collagen, type V, alpha 2 221729_at 3.16E-05 DKK1 1.24 dickkopf homolog 1 (Xenopus laevis) 204602_at 0.00018 EFEMP2 1.19 EGF-containing fibulin-like extracellular matrix protein 2 209356_x_at 0.000215 AGRN 1.06 agrin 212285_s_at 0.000209 TUFT1 1.06 tuftelin 1 205807_s_at 0.000123 TGFB1 0.88 transforming growth factor, beta 1 203085_s_at 0.00066 WNT5A 0.77 wingless-type MMTV integration site family, member 5A 205990_s_at 0.000817 LAMC1 0.56 laminin, gamma 1 (formerly LAMB2) 200770_s_at 0.00184