1. Kinase Inhibitors 1. Kinase Inhibitors Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

A-83-01 【 TGF-β R I Kinase Inhibitor IV】

018-22521 2 mg for Cellbiology 909910-43-6 DMSO - Keep at -20℃. 014-22523 10 mg Selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7. Inhibits Smad2/3 phosphorylation and TGF-β-induced epithelial-to-mesenchymal transition. This product has little or no effect on bone morphogenetic protein type I receptors, p38 MAP kinases, and extracellular-regulated kinases.

17-AAG, 97.0+ % (HPLC)

012-20101 1 mg for Cellbiology 75747-14-7 DMSO, methanol EC50 of HSP90 = 7.2 μM Keep at -20℃. Synthetic derivative of geldanamycin, which is one of the ansamycin antibiotics. 17-AAG inhibits the function of HSP90 by binding to the ATP binding site of HSP90. HSP90 inhibitors dephosphorylate Akt resulting in inactivation of Akt and apoptosis.

AG 490, 95+% (TLC)

IC of Dephosphorylation of EGF DMSO, DMF, 50 013-17181 5 mg for Biochemistry 134036-52-5 receptor tyrosine kinase: 1.2 μmol; Keep at -20℃. methanol EGF dependent cell proliferation: 6 μmol Specific and potent JAK-2 protein tyrosine kinase inhibitor. Also inhibits EGF receptor autophosphorylation.

AG 1296

016-20121 5 mg for Cellbiology 146535-11-7 DMSO - Keep at -20℃. It inhibits signaling in human PDGF (platelet-derived growth factor) α receptor, PDGF β receptor, stem cell stimulating factor c-kit and FGF (fibroblast growth factor) receptor.

AG 1478

017-20151 5 mg for Cellbiology 175178-82-2 DMSO - Keep at -20℃. Potent and selective inhibitor of EGF receptor kinase. Decrease in EGF-stimulating DNA synthesis and inhibition of activation of EGF- dependent src family kinase have been reported.

ALK5 Inhibitor, 96.0+ % (HPLC)

012-23021 1 mg for Cellbiology 446859-33-2 methanol - Keep at -20℃. Potent and selective ATP-competitive inhibitor of TGF-β RI kinase/ALK5. Can be used as substitute of Sox2 or c-Myc (Yamanaka 4 factors) in induction of murine iPS cells.

Aminogenistein, 90.0+ % (HPLC)

017-15901 1 mg for Biochemistry 132018-32-7 Ethanol, DMSO IC50 of lck = 1.2 μM Keep at -20℃. Inhibitor of PTK, especially p56lck. The product, even among other flavons, is able to specifically inhibit lck activity at a low dose and is therefore employed as an useful tool for clarification of the mechanism of immune response activation.

Apigenin, 95+ % (TLC)

010-18914 5 mg

016-18911 10 mg for Biochemistry 520-36-5 Methanol - Keep at 2-10℃. 012-18913 50 mg

AS 604850, 98.0+ % (HPLC)

IC50 of PI3Kα: 4.5 μM; PI3Kγ: 250 nM; 015-23131 5 mg for Cellbiology 648449-76-7 DMSO Keep at 2 - 10℃ PI3Kβ, PI3Kδ: 250 nM Thiazolidine-dione compound, which is a potent, cell permeable and ATP-competitive inhibitor of PI3K γ. It exhibits highly selectivity.

1 Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

AS 605240, 95.0+ % (HPLC)

IC50 of PI3Kα: 60 nM; PI3Kγ: 270 nM; 012-23141 5 mg for Cellbiology 648450-29-7 DMSO Keep at 2 - 10℃

1. Kinase Inhibitors 1. PI3Kβ: 8 nM; PI3Kδ: 300 nM Thiazolidine-dione compound, which is a potent, cell permeable and ATP-competitive inhibitor of PI3K γ (Ki = 180 nM). It exhibits highly selectivity.

ATM Kinase Inhibitor, 97.0+ % (HPLC)

015-22911 2 mg for Cellbiology 587871-26-9 Ethanol ATM: IC50 = 13 nM; Ki = 2.2 nM Keep at -20℃. Cell-permeable, ATP-competitive inhibitor of ATM kinase. Shows high ATM kinase selectivity for PIKK and PI3K family kinases.

6-Bromoindirubin-3'-oxime【 BIO】【 GSK-3 Inhibitor IX】, 95.0+ % (HPLC)

029-16241 1 mg for Cellbiology 667463-62-9 - - Keep at 2 - 10℃ Potent and reversible ATP-competitive inhibitor. It shows to activate the Wnt signaling pathway and maintain pluripotencies in human and murine ES cells and also promotes cardiomyocyte proliferation and acts as a GSK-3 inhibitor.

Butein, 98.0+ % (HPLC)

027-14461 10 mg for Biochemistry 487-52-5 Methanol, DMSO - Keep at -20℃. Tyrosine kinase inhibitor isolated from plant polyphenols. Reported to activate SIrt1 (Class III HDAC).

Calphostin C, 95.0+ % (HPLC)

030-15133 50 μg IC50 of PKC: 50 nM; HeLa S3: 0.23 μg/mL; for Cellbiology 121263-19-2 DMSO, DMF Keep at 2-10℃. 034-15131 100 μg MCF-7: 0.18 μg/mL Specific protein kinase C (PKC) inhibitor. Shows strong anticellular activity against a variety of cultured cells.

Carbonyl Cyanide m-Chlorophenylhydrazone, 97+% (TLC)

034-16993 100 mg for Biochemistry 99534-03-9 Ethanol, acetone - Keep at -20℃. 038-16991 1 g Potent uncoupler of oxidative phosphorylation that inhibits mitochondrial function.

CKI-7 Dihydrochloride, 97.0+ % (HPLC)

034-21501 5 mg for Cellbiology - Water - Keep at -20℃. Casein kinase (CK1) inhibitor. Use with SB431542 and Y-27632 induces differentiation of human ES cells and human iPS cells into retinal progenitor cells in serum- and feeder cell-free culture medium.

Compound 15e, 98.0+ % (HPLC)

IC50 of PI3Kα: 2 nM; PI3Kβ: 16 nM; 031-21491 5 mg for Cellbiology 371943-05-4 Ethanol Keep at 2 - 10℃ PI3Kγ: 660 nM; PI3KC2β: 220 nM Permeable morpholino pyrimidine compound. A highly selective PI3Kα inhibitor.

Compound 401, 98.0+ % (HPLC)

033-21951 1 mg IC50 of DNA-PK: 0.28 μM; mTOR: 5.3 μM; for Cellbiology 168425-64-7 Methanol Keep at -20℃. 039-21953 5 mg ATM, ATR ＞ 100 μM Reversible and selective DNA-PK and mTOR inhibitor. It exhibits negligible affinity to PI3K, ATM and ATR. It has been known to nhibiti mTOR- dependent proliferation and induce apoptosis in TSC1-/- mouse embryo fibroblasts.

Deguelin

Acetone, 047-29211 5 mg for Cellbiology 522-17-8 dichloromethane, - Keep at 2-10℃. acetonitrile, DMSO Akt (Protein Kinase B; PKB) inhibitor. It inhibits proliferation of cells in the GM-2 stage of cell cycle. It induces apoptosis in the precancerous and cancerated cell lines. 2 for other products, please visit the Wako Online Catalog www.e-reagent.com Product Name 1. Kinase Inhibitors

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Dibucaine Hydrochloride, 98.0+ % (after drying)(Titration)

Water, glacial acetic 049-20011 1 g for Biochemistry 61-12-1 acid, ethanol, acetone - Keep at RT. and chloroform. Lipophilic PKC inhibitor. Inhibits Na+ and K+-ATPase activities, too.

Dorsomorphin, 99.6% (HPLC, the initiall lot)

045-31221 1 mg for Cellbiology 866405-64-3 Methanol - Keep at 2 - 10℃ 041-31223 5 mg Permeable pyrazolopyrimidine compound, which is potent, selective and reversible ATP-competitive inhibitor of AMPK (AMP-activated protein kinasse). It has been shown to inhibit BMP signal strongly by inhibition of BMP type I receptors (ALK-2, ALK-3 and ALK- 6).

Dorsomorphin Dihydrochloride, 98.0+ % (HPLC)

047-31801 1 mg for Cellbiology 1219168-18-9 Water - Keep at 2 - 10℃ 043-31803 5 mg This substance inhibits bone morphogenic factor (BMP) type I receptors (ALK2, ALK3 and ALK6). It has been shown to inhibit BMP signal necessary for embryogenesis and accelerates important nerve differentiation from human pluripotential stem cells. It also functions as a potent, selective and reversible ATP-competitive inhibitor of AMP-activating protein kinase (AMP-K).

Geldanamycin, from Streptomyces hygroscopicus, 95.0+ % (HPLC)

077-04571 100 μg for Biochemistry 30562-34-6 Methanol - Keep at -20℃. This product is an antitumor agent that has a benzoquinoid skeleton and has a pp60src tyrosine kynase inhibitory potency. Its pharmacological action is more potent than that of herbimycin, which has a similar structure.

Genistein, 98.0+ % (HPLC)

073-05531 20 mg for Cellbiology 446-72-0 Ethanol - Keep at -20℃. 079-05533 100 mg Isoflavone compound. Tyrosine kinase inhibitor by antagonizing against ATP. Known to inhibit the proliferation of various solid tumor cells and induce the differentiation of the tumor cells.

Genistin, from Soybean; 98.0+ % (HPLC)

070-04681 10 mg for Biochemistry 529-59-9 Hot methanol - Keep at 2-10℃. 076-04683 100 mg Soy extract isoflavone, or glucoside. Cancer-suppressing effects, antioxidant effects, and osteoporosis preventive effects have been reported.

GF 109203X, 90.0+ % (HPLC)

079-03811 1 mg for Cellbiology 133052-90-1 DMSO IC50 of PKC: 10 nM Keep at 2 - 10℃ Potent and selective PKC inhibitor among bisindolylmaleimides, which have an inhibatory action on PKC. The structure is similar to that of staurosporine.

Gö 6983

IC50 of PKCα: 7 nM; PKCβ: 7 nM; PKCγ: 6 nM; 070-05801 1 mg for Cellbiology 133053-19-7 DMSO Keep at -20℃. PKCδ: 10 nM; PKCζ: 60 nM; PKCμ: 20μM Cell-permeable PKC inhibitor

GSK 269962A, 97.0+ % (HPLC)

070-05921 2 mg for Cellbiology 850664-21-0 DMSO, acetonitrile IC50 of ROCK-I: 1.6 nM; ROCK-II: 6 nM Keep at 2 - 10℃ ROCK Inhibitor. Not available for sale in the USA due to patent.

3 Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

GSK 429286A, 97.0+ % (HPLC)

Ethanol, DMSO, 073-05911 2 mg for Cellbiology 850664-21-0 IC50 of ROCK: 14 nM Keep at 2 - 10℃

1. Kinase Inhibitors 1. water ROCK inhibitor. It cancels out adrenaline-induced contraction of the aortic valve in rats and lowers the mean blood pressure in the arteries of hypertensive rats.

H-1152 Dihydrochloride

088-09281 1 mg for Cellbiology 871543-07-6 Water IC50 of ROCK-II: 12 nM Keep at -20℃. ROCK inhibitor. Its inhibitory activity is more potent than that of Y-27632. It exhibits weak affinity to other serine/threonine kinases.

Herbimycin A, 98.0+ % (HPLC)

085-06491 1 mg for Biochemistry 70563-58-5 Methanol, DMSO - Keep at 2-10℃. Tyrosine kinase inhibitor by binding to the SH group of cysteine in oncogene src. It also inhibits transformation activity of oncogenes (src, yes, fps, ros, abl, erbB) that have tyrosine kinase activity. It also has the unique ability to restore RSVts-NRK cells to their normal form.

Hypericin, from Hypericum perforatum

086-07761 1 mg for Biochemistry 548-04-9 Water-THF - Keep at 2 - 10℃ 082-07763 5 mg Inhibitor of PKC, insulin receptor, EGF receptor, casein kinase II, and thyrosine kinase activity of MAPK. It also exhibits antivirus and antiretrovirus activities.

IPA-3, 97.0+ % (HPLC)

093-06231 5 mg for Cellbiology 42521-82-4 DMSO, acetonitrile PAK1: IC50 = 2.5 μM Keep at 2 - 10℃ p21 activation kinase (PAK) inhibitor, which binds to the regulatory domain of PAK and accelerates inactivation of PAKs structure. Shows high selectivity to PAK1 in particular. PAK1 involves in tumor formation and metastasis.

K-252a

113-00561 50 μg

119-00563 100 μg for Biochemistry 97161-97-2 Ethyl acetate - Keep at -20℃.

117-00564 250 μg Selective inhibitor of PKA (cyclic AMP-dependent protein kinase), PKC (phospholipid-dependent protein kinase) and PKG (cyclic GMP- dependent protein kinase).

K-252b

110-00571 50 μg for Biochemistry 99570-78-2 Methanol - Keep at -20℃. 114-00574 250 μg Selective inhibitor of PKA (cyclic AMP-dependent protein kinase), PKC (phospholipid-dependent protein kinase) and PKG (cyclic GMP- dependent protein kinase).

Kenpaullone

110-00831 1 mg for Cellbiology 142273-20-9 DMSO - Keep at -20℃. 116-00833 5 mg Potent GSK-3β and CDK inhibitor. Inhibits antagonistically ATP binding. Reported to be substitutable for Klf4, one of the 4 Yamanaka factors (Oct3/4, Klf4, Sox2, c-Myc), in iPS cell production. Also reported to improve reprogramming efficiency if added upon the introduction of 4 Yamanaka factors.

Ki 8751, 96.0+ % (HPLC)

112-00891 5 mg for Cellbiology 228559-41-9 DMSO IC50 = 0.9 nM Keep at -20℃. Potent and selective VEGFR-2 tyrosine kinase inhibito.

4 for other products, please visit the Wako Online Catalog www.e-reagent.com Product Name 1. Kinase Inhibitors

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

KN-62

118-00631 1 mg Ca2+ / calmodulin-dependent protein for Biochemistry 127191-97-3 Methanol, DMSO Keep at 2-10℃. 114-00633 5 mg kinase II (in rat brain): IC50 = 0.3 μM Selective inhibitor of Ca calmodulin-dependent protein kinase II in the rat brain. It inhibits the proliferation of K562 cells (1 μM). KN-93

115-00641 1 mg Ca2+ / calmodulin-dependent protein for Biochemistry 139298-40-1 Methanol Keep at 2-10℃. 111-00643 5 mg kinase II (in rat brain): IC50 = 2.0 μM Selective inhibitor of Ca calmodulin-dependent protein kinase II in the rat brain. Inhibits insulin release from isolated islands of Langerhans caused by glucose induction and forskolin stimulation. It induces stoppage of the cell cycle in theG1 phase and apoptosis in NIH3T3 cells.

KN-93, Water-Soluble

114-00731 1 mg for Cellbiology - Water - Keep at -20℃. Selective inhibitor of Ca calmodulin-dependent protein kinase II in the rat brain. Inhibits insulin release from isolated islands of Langerhans caused by glucose induction and forskolin stimulation. It induces stoppage of the cell cycle in theG1 phase and apoptosis in NIH3T3 cells.

KT 5720

117-00581 50 μg

113-00583 100 μg for Biochemistry 108068-98-0 Methanol - Keep at -20℃.

111-00584 250 μg K252a derivative and membrane permeable PKA (cyclic AMP-dependent protein kinase) inhibitor

KT 5823

114-00591 50 μg Ethyl acetate, 110-00593 100 μg for Biochemistry 126643-37-6 - Keep at -20℃. methanol 118-00594 250 μg Cell-permeable PKC inhibitor

KU 0063794, 98.0+ % (HPLC)

Acetone,

115-00881 5 mg for Cellbiology 938440-64-3 dichloromethane, IC50 of mTOR1: 10 nM; mTOR2: 10 nM. Keep at 2-10℃. acetonitrile, DMSO Selective mTOR (mammalian target of rapamycin) inhibitor. Shows no inhibitory activity against 76 types of protein kinases including PI3K even at 1,000-fold concentration.

LDN 193189 Hydrochloride, 98.0+ % (HPLC)

124-06011 2 mg for Cellbiology 1062368-62-0 Water IC50 of ALK2: 5 nM; ALK3: 30 nM. Keep at 2 - 10℃ This product inhibits ALK2 and ALK3, which are BMP type I receptors, and consequently inhibits phosphorylation of Smad1, Smad5 and Smad8.

LY 294002, 97.0+%（HPLC)

129-04861 5 mg

IC50 of PI3-kinase: 1.4 μM; 125-04863 10 mg for Biochemistry 154447-36-6 Ethanol, acetone Keep at 2-10℃. Histamine secretion by PBL-2H3: 5 μM. 123-04864 25 mg Highly cell-permeable, specific phosphatidylinositol 3-kinase (PI3-kinase) inhibitor. It inhibits the proliferation of rabbit aorta smooth muscle cells without inducing apoptosis. It is also reported to inhibit histamine secretion by RBL-2H3 cells.

5 Product Name

Wako Cat. No. Pkg. Size Grade/Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Tyr

Peptide Institute 331-43741 0.5 mg - Water IC50 = 4.1 nM Keep at -20℃.

1. Kinase Inhibitors 1. (4374-v) Inhibitor of calmodulin-dependent protein kinase II.

3-Methyladenine

131-17671 100 mg for Biochemistry 5142-23-4 - - Keep at -20℃. 137-17673 1 g This product prevents downstream mTOR kinase activity degradation by inhibition of PI3-kinase , which in turn suppresses autophagy.

NSC 693868, 98.0+ % (HPLC)

140-08891 5 mg for Cellbiology 40254-90-8 DMSO - Keep at 2 - 10℃ Selective inhibitor of GSK-3β and CDK5.

NU 7026, 97.0+ %

IC50 of DNA-PK: 0.23 μM; PI3K: 13.0 μM; 145-08841 5 mg for Cellbiology 154447-35-5 DMSO Keep at 2 - 10℃ ATM, ATR ＞100 μM ATP-competitive inhibitor of the protein kinase DNA-PK (DNA-dependent protein kinase).

NU 7441, 98.0+ % (HPLC)

143-09001 1 mg IC50 of DNA-PK: 14 μM; mTOR: 1.7 μM; for Cellbiology 503468-95-9 Methanol Keep at -20℃. 149-09003 5 mg PI3K: 13.0 μM; ATM, ATR ＞100 μM Potent, reversible and selective inhibitor of DNA-PK (DNA-dependent protein kinase) and mTOR. Has little affinity with PI3K, ATM, and ATR. Known to inhibit mTOR-dependent proliferation and induce apoptosis in TSC1-/- mouse embryonic fibroblasts.

Olomoucine, 97+ % (TLC)

157-01901 5 mg for Biochemistry 101622-51-9 DMSO - Keep at -20℃. It inhibits p34cdc/cyclin B, p33cdk2/cyclin A, p33cdk2/cyclin E, cerebral p33cdk5/p35 and erk1/MAPK, and it has been reported to inhibit in vitro the transition of the G2/M phase in the oocytes of starfish, and the transition of the G1/S phase in the mesophyll protoplasts of petunia.

PD-98059, 95+ % (TLC)

169-19211 5 mg for Biochemistry 167869-21-8 Ethanol, acetone - Keep at -20℃. MAPK-1 inhibitor. This product has been reported to inhibit MAPK activation by insulin and block completely the increase in cell growth and MAP activity induced by leptin (obesity regulating hormone). The resting cell pretreated with PD-98059 has been demonstrated to inhibit a great deal the expression of the advance early genes c-fos and eggr-1 induced by a peroxisome proliferative agent.

PD 173074

166-24351 5 mg for Cellbiology 219580-11-7 Methanol - Keep at 2-10℃. ATP competitive type FGF receptor inhibitor. The FGF signaling pathway is associated with spontaneous proliferation of stem cells in a host of systems.

PD 184352, 98.0+ % (HPLC)

169-25181 5 mg for Cellbiology 212631-79-3 Methanol, DMSO - Keep at 2-10℃. Poteent and selective inhibitor of MEK1. Recent studies showed that culturing ES cells in a medium containing CHIR99021, SU5402, PD184352 allows for highly-efficient suppression of differentiation.

6 for other products, please visit the Wako Online Catalog www.e-reagent.com Product Name 1. Kinase Inhibitors

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

PD 0325901

162-25291 5 mg for Cellbiology 391210-10-9 Methanol, DMSO IC50 of MEK: 0.33 nM Keep at -20℃. 168-25293 25 mg MAPK inhibitor with potent antitumor activity. It induces phosphorylation of MAPK, inhibition of its activation and inhibition of tumor cell proliferation. PD0325901 inhibits MAPK activity without adverse reactions. Addition of this product and CHIR99021 to a culture medium results in efficient culture of mouse ES cells.

Phloretin, 98.0+ % (HPLC)

160-17781 250 mg for Biochemistry 60-82-2 Methanol IC50 = 16 μM Keep at 2 - 10℃ The aglycone moiety of phlorizin, a specific inhibitor of the sugar active transport system, which is actually responsible for the inhibitory action of phlorizin. When used alone, phloretin has been reported to be less effective for the active transport system while it is known to be more inhibitory than phlorizin to the carrier transport system, suggesting a difference in the mode of action according to structure. It is also useful as means for the study of the kinetics and regulatory mechanisms of PKC as a non-specific inhibitor of PKC.

PI-103, 98.0+ % (HPLC)

163-24241 1 mg for Cellbiology 371935-74-9 DMSO - Keep at -20℃. 169-24243 10 mg Potent, cell-permeable and ATP-competitive inhibitor of DNA-PK, PI-3K, and mTOR with selectivity for a wide range of lipids and protein kinases. Reported to inhibit PIP3 production, insulin signal transduction, and Akt phosphorylation, suppress cell proliferation, and induce cell death.

Piceatannol

169-21661 10 mg for Cellbiology 10083-24-6 Ethanol - Keep at 2 - 10℃ Selective inhibitor of non-reception type tyrosine kinase Syk. An activator of human deacetylase class III (SIrt1).

PIK-75 Hydrochloride, 98.0+ % (HPLC)

IC50 of PI3Kα: 0.3 nM; PI3Kβ: 850 nM; 162-24451 5 mg for Cellbiology - Water-methanol Keep at 2 - 10℃ PI3Kγ: 40 nM; PI3K C2β: 100 nM Cell-permeable imidazopyridine compound, which is a selective inhibitor of PI3Kα.

PKC 412, 96.0+ % (HPLC)

164-25751 1 mg for Cellbiology 120685-11-2 - - Keep at -20℃. 160-25753 10 mg Wide range of kinase inhibitor. Inhibits PKC, PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1,EGFR, etc.

PP 2, 94.0+ % (HPLC)

166-20331 1 mg for Biochemistry 172889-27-9 Methanol, DMSO - Keep at -20℃. Src family tyrosine kinase inhibitor.

PP 3, 94.0+ % (HPLC)

163-20341 1 mg for Biochemistry 5334-30-5 Methanol - Keep at -20℃. EGF receptor type tyrosine kinase inhibitor

PP 242, 98.0+ % (HPLC)

IC50 of mTOR: 8 nM; PI3Kα: 2 μM; PI3Kβ: 165-24441 5 mg for Cellbiology 1092351-67-1 DMSO Keep at 2-10℃. 2.2 μM; PI3Kγ: 1.3 μM; PI3Kδ: 0.1 μM Potent and selective mTOR (mammalian target of rapamycin) inhibitor

7 Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Quercetin Dihydrate

171-00404 100 mg

1. Kinase Inhibitors 1. 177-00401 1 g Practical Grade 6151-25-3 Ethanol, acetone - Keep at RT. 173-00403 10 g Yellow flavonoid. Has antioxidant and anti-tumor effects. Its fat absorption inhibitory effect is particularly strong compared with other polyphenols, and it aids in eliminating the body fat. Boosts the fat metabolism in the liver, increases fat combustion, and inhibits fat absorption by binding to fat in the digestive tract. Also said to reduce the inflammation in pollinosis.

Rac1 Inhibitor, 98.0+ % (HPLC)

180-02491 5 mg for Cellbiology - Water - Keep at 2-10℃. Selective inhibitor of Rac1-GEF interaction. Specifically inhibits Rac1 activity by inhibiting the interactions between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors), TrioN and Tiam1.

Radicicol, 97.0+ % (HPLC)

Ethanol, methanol, 183-01901 1 mg for Cellbiology 12772-57-5 - Keep at -20℃. DMSO Macrocyclic lactone antifungal antibiotic with antimalarial activity. It inhibits a heat shock protein 90 (HSP90) and protein tyrosine kinase.

Rapamycin (mixture of isomers)

184-02531 1 mg

180-02533 10 mg for Cellbiology 53123-88-9 - - Keep at -20℃. 188-02534 50 mg Macrolide immunosuppressive agent. A structural analog of FK506 that binds to FK506 binding proteins (FKBPs) but does not inhibit calcineurin activity. The rapamycin-FKBP complex inhibits the signal from IL-2 by inhibiting the kinase activity of mTOR. Inhibits G1-to-S phase transition of the cell cycle.

RG-14620

188-02811 10 mg for Cellbiology 136831-49-7 - IC50 = 3μM Keep at -20℃. 184-02813 50 mg EGFR tyrosine kinase inhibitor

Ro 31-8220 Methanesulfonate

IC50 of PKCα: 5 nM; PKCβI: 24 nM; 186-02591 1 mg for Cellbiology 138489-18-6 Ethanol PKCβII: 14 nM; PKCγ: 27 nM; PKCε: 24 nM; Keep at 2-10℃. PKA: 0.9 μM; CaM kinase II: 17 μM A structural analog of staurosporine. Potent, cell-permeable PKC inhibitor. Its selectivity for PKAs and CaM kinase II is low, and it also has inhibiting effects on glycogen synthase kinase 3 (GSK3) and voltage-dependent Na channels.

Roscovitine, 98.0+ % (HPLC)

182-01591 1 mg DMSO, ethanol, for Biochemistry 186692-46-6 - Keep at -20℃. 188-01593 10 mg acetone Olomoucine analog and CDK2 and CDK5 inhibitor. In Alzheimer's disease, it is believed to be associated with hyperphosphorylated tau.

SB 202190

193-13531 1 mg for Cellbiology 152121-30-7 Methanol - Keep at -20℃. Potent and selective inhibitor of the p38α and β isoforms of p38 MAPK family. Shows membrane permeability. It has no effect on ERK and JNK MAPK.

8 for other products, please visit the Wako Online Catalog www.e-reagent.com Product Name 1. Kinase Inhibitors

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

SB 203580, 98.0+ % (HPLC)

199-16551 1 mg IC50 of SAPK2a / p38: 50 nM; for Cellbiology 152121-47-6 DMSO, methanol Keep at -20℃. 195-16553 10 mg SAPK2b / p38β2: 50 nM Specific MAPK p38α and p38β inhibitor. Also used to separate and maintain embryonic stem cells (ES cells).

SB 203580 Hydrochloride, 98.0+ % (HPLC)

IC50 of p38α (in vitro): 34 nM; 198-16761 1 mg for Cellbiology 869185-85-3 Water Keep at -20℃. (in vivo): 600 nM Specific MAPK p38α and p38β inhibitor. Also used to separate and maintain embryonic stem cells (ES cells).

SB 415286, 98.0+ % (HPLC)

197-15751 5 mg for Cellbiology 264218-23-7 DMSO - Keep at -20℃. Potent, cell-permeable, and selective GSK-3 inhibitor. GSK-3β inhibitors are used in a variety of stem cell research including ES cells and iPS cells. Reduces the cell death of cerebellar granule neurons in vivo. Also increases cytoplasmic β-catenin concentration and inhibits GSK-3-dependent tau phosphorylation. Also reported to stimulate glycogen synthesis and gene transcription and have protective effects on the heart and nerves.

SB 431542, 98.0+ % (HPLC)

192-16541 5 mg for Cell Culture 331752-47-7 DMSO IC50 of ALK = 7 nM Keep at -20℃. 198-16543 25 mg Selective inhibitor of activin receptor-like kinase (ALK) 4, 5 and 7 (the TGF-β type I receptor). Promotes proliferation, differentiation and sheet formation of endothelial cells of ES cell origin. Can be able to grow dramatically efficiency reprogramming to Human iPS Cells when used with Thiazovivin and PD0325901. It also promotes the speed.

SP 600125, 98.0+ % (HPLC)

197-16591 5 mg IC50 of JNK1: 40 nM; JNK2: 40 nM; for Cellbiology 129-56-6 Acetone, DMSO Keep at -20℃. 193-16593 25 mg JNK3: 90 nM

D-erythro-Sphingosine, 99+% (TLC)

Methanol- 192-11161 25 mg for Biochemistry 123-78-4 IC50 of PKC: 1 - 3 μM Keep at -20℃. chloroform mixture Selective PKC inhibitot. It exhibit inhibitory action competitively to diacylglycerol, phorbol dibutyrate and Ca2+. It does not affect the activities of MLCK and PKA. It has also been reported to induce apoptosis in human myelocytic leukemia cells, HL-60.

SR 3677 Hydrochloride, 98.0+ % (HPLC)

195-16151 2 mg for Cellbiology 1072959-67-1 Water, DMSO IC50 of ROCK-I: 56 nM, ROCK-II: 3 nM Keep at RT. Potent ROCK inhibitor

Staurosporine, 95.0+ % (HPLC)

197-10251 100 μg IC50 of PKC: 2.7 nM; PKA: 8.2 nM; for Biochemistry 62996-74-1 DMSO v-src Keep at -20℃. 193-10253 500 μg p60 tyrosine kinase: 6.4 nM A microbial alkaloid and extremely potent inhibitor of protein kinase Cs (PKCs). Also has comparable inhibitory actions on cAMP-dependent protein kinases (PKAs) and p60v-src tyrosine kinase, the product of an oncogene src.

Stellettamide A Trifluoroacetate, 95.0+ % (HPLC)

193-11831 100 μg for Biochemistry 129744-24-7 Methanol - Keep at -20℃. Substance isolated and extracted from sponge (Stelletta sponge). It inhibits calmodulin.

9 Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

SU 4312, 97.0+ % (HPLC)

Ki: unactivated form: 0.04 μM; 190-15861 5 mg for Cellbiology - Ethanol Keep at -20℃.

1. Kinase Inhibitors 1. activated form: 4 μM VEGFR2 tyrosine kinase inhibitor. Also Inhibits angiogenesis in tumors.

SU 5402, 95.0+ % (HPLC)

193-16071 1 mg for Cellbiology 215543-92-3 DMSO - Keep at -20℃. Tyrosine kinase inhibitor in fibroblast growth factor receptor 1 (FGFR1). It also inhibits phosphorylation of ERK1 and ERK2 induced by aFGF. A recent study has demonstrated inhibition of differentiation at a high efficiency by incubating ES cells in a medium containing CHIR99021, SU5402 and PD184352.

SU 5416, 97.0+ % (HPLC)

IC50 of VEGFR2: 1.3 μM; FGFR1: 4.2 μM; 196-15841 5 mg for Cellbiology 204005-46-9 Ethanol Keep at -20℃. PDGFRβ: 37.9 μM VEGFR2 tyrosine kinase inhibitor. Also Inhibits angiogenesis in tumors.

SU 6668, 98.0+ % (HPLC)

IC50 of VEGFR2: 3.9 μM; FGFR1: 3.8 μM; 193-15851 5 mg for Cellbiology 252916-29-3 Ethanol Keep at 2 - 10℃ PDGFRβ: 0.10 μM VEGFR2 tyrosine kinase inhibitor

SU 11274, 95.0+ % (HPLC)

198-17121 5 mg IC50 of c-MET tyrosine kinase: 10 nM; for Cellbiology 658084-23-2 - VEGFR1/2 tyrosine kinase: 0.8 mM; Keep at -20℃. 194-17123 25 mg PDGFR: 19.4 mM

Selective inhibitor of c-MET tyrosine kinase.

Tamoxifen Citrate, 98.0+ % (Ti)

209-14361 250 mg 205-14363 1 g IC50 of PKC: 2.7 nM; PKA: 8.2 nM; for Biochemistry 54965-24-1 Ethanol v-src Keep at 2-10℃. 203-14364 5 g p60 tyrosine kinase: 6.4 nM 207-1436225 g Estrogen analog, which is used as a drug used for prophylactic therapy of breast cancer, is known to selectively bind to estrogen receptors and is also called SERM (selective estrogen receptor modifier). It is considered to be deeply associated with diseases such as breast cancer and osteoporosis.

Triciribine, 95.0+ % (HPLC)

206-19371 5 mg for Cellbiology 35943-35-2 - IC50 of AKT kinase: 150 nM Keep at -20℃. Triciribine is inhibitor of AKT1/2/3 kinase and DNA synthesis inhibitor.

TWS 119, 90.0+ % (HPLC)

206-17671 1 mg for Cellbiology 601514-19-6 Methanol - Keep at 2 - 10℃ 202-17673 5 mg Acts as a potent and selective inhibitor of GSK-3β. Also reported to selectively induce neuronal differentiation in murine embryonic stem cells.

Tyrphostin A25, 95.0+ % (HPLC)

204-19311 10 mg for Cellbiology 118409-58-8 - IC50: 3 μM Keep at -20℃. 200-19313 50 mg EGFR tyrosine kinase inhibitor

10 for other products, please visit the Wako Online Catalog www.e-reagent.com Product Name 1. Kinase Inhibitors

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

U 0126 (mixture of isomers), 95.0+ % (HPLC)

211-01051 5 mg for Biochemistry 109511-58-2 Acetonitrile, ethanol - Keep at -20℃.

W-5 Hydrochloride

236-01721 5 mg for Biochemistry 61714-25-8 Methanol, water IC50 of PDE: 240 μM; MLCK: 230 μM Keep at -20℃. 232-01723 25 mg A naphthalenesulfonate amide calmodulin antagonist to inhibit Ca2+/calmodulin-dependent phosphodiesterase (PDE) and myosin light chain kinase (MLCK). However, compared to W-7, its action as a calmodulin antagonist is low, and the product is mainly used as a negative control of W-7.

W-7 Hydrochloride

233-01731 5 mg

239-01733 50 mg for Biochemistry 61714-27-0 Methanol, water IC50 of PDE: 28 μM; MLCK: 51 μM Keep at -20℃. 237-01734 250 mg A naphthalenesulfonate amide calmodulin antagonist to inhibit Ca2+/calmodulin-dependent phosphodiesterase and myosin light chain kinase.

(+)-Wortmannin, 97.0+ % (HPLC)

230-02341 2 mg for Cellbiology 19545-26-7 Ethanol - Keep at -20℃. 236-02343 10 mg Has selective and irreversible inhibitory actions on myosin light chain kinases, a type of protein kinase that regulates smooth muscle contraction etc., and concentration-dependent and irreversible inhibitory actions on phosphatidylinositol 3-kinases, which are involved in phosphatidylinositol metabolism, one of the intracellular signal transduction mechanisms.

Y-27632, 98.0+ % (HPLC)

257-00511 1 mg

253-00513 5 mg for Cellbiology 146986-50-7 Water p160ROCK (Ki = 140 nM) Keep at -20℃. 251-00514 25 mg Selective and potent ROCK inhibitor. It inhibits contraction of the vascular smooth muscle, infiltration of cancer cells, and egulationr of cell differentiation caused by a signal transduction system of ROCK. Enhances survival rate after cryopreservation and cloning efficiency of human ES and iPS cells.

5 mmol/L Y-27632 Solution

253-00591 300 μL for Cell Culture 331752-47-7 - - Keep at -20℃. 5 mmol/L Y-27632 in aqueous soution.

11 2. Protein Phosphatase Inhibitors Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Calyculin A, 95.0+ % (HPLC)

038-14453 10 μg Methanol, ethanol, IC of PP2A: 3 nM; smooth muscle: 5 nM; for Biochemistry 101932-71-2 Keep at -20℃. 032-14451 100 μg DMSO smooth muscle endogenous: 1 nM Contracts the smooth muscle regardless of the presence of external calcium, with its effects being approximately 100 times more potent than okadaic acid. A variety of actions have been confirmed, such as equally-potent inhibition of type 1 and 2A phosphatase activities and promotion of protein phosphorylation.

Cantharidin

Inhibitors 036-20461 25 mg

Protein Phosphatase Protein 032-20463 100 mg for Cellbiology 56-25-7 Acetone IC50 of PP2A: 40 nM; PPA: 473 nM Keep at 2-10℃. 2. 2. 030-20464 500 mg Potent and selective protein phosphatase 2A inhibitor. Also inhibits protein phosphatase 1 at high concentrations.

Cyclosporin A, 97.0+ % (HPLC)

031-18963 50 mg Methanol, ethanol, for Cellbiology 59865-13-3 acetone, ether, - Keep at 2-10℃. 035-18961 200 mg chloroform It is a representative immunosuppressant used for prevention of rejection reaction at the time of organ transplantation and it binds to the intracellular receptor in T lymphocytes inhibiting IL-2 and IFN-γ transcription (calcineurin inhibition). Consequently, it inhibits activation and proliferation of helper T cells contributing to immune reaction.

Fostriecin Sodium Salt

065-05051 10 μg for Cellbiology 87860-39-7 Ethanol, water IC50 of PP1: 131 nM; PP2A: 3.2 nM Keep at -20℃. An antibiotic with anti-tumor activity isolated from Streptomyces pulveraceous (subspecies fostreus). Binds near the active center of the catalytic subunit of PP2A and inhibits substrate dephosphorylation. Does not affect PP2B enzyme activity but shows inhibitory action on PP1 as well at high concentrations.

RK-682, 95.0+ % (HPLC)

185-01341 1 mg for Biochemistry - Ethanol, acetone IC50 of CD45: 54 μM; VHR: 2.0 μM Keep at RT. Specific tyrosine phosphatase inhibitor, which inhibits dephosphorylation of CD45 or VHR, protein-tyrosine phosphatase (PTPase), and regulates the cell cycle from G1 to S period.

Tautomycin

IC of PP2A, PP1 (smooth muscle): Chloroform, 50 209-12041 100 μg for Biochemistry 109946-35-2 32 nM; PP1 (skeletal muscle): 22 nM; Keep at -20℃. ethanol, methanol Smooth muscle endofenous: 6 nM Protein phosphatase inhibitor and antifungal antibiotic produced from Streptomyces spiroverticillatus.

Disodium β-Glycerophosphate Pentahydrate, 95.0+ % (Titration)

046-31251 50 g for Cellbiology 13408-09-8 Water: 1 g/20 mL - Keep at 2-10℃. 042-31253 250 g Has a structure of phosphorylated glycerol and in animal tissues is released into the blood with the breakdown of triglycerides in the liver. Also produced as a glycolytic intermediate.

Levamisole Hydrochloride, 98.0+ % (Titration)

Water: 210 g/L 123-04641 10 g for Biochemistry 16595-80-5 - Keep at RT. (20℃) Powder type of alkaline phosphatase inhibitor. It promotes the maturation of T lymphocytes and increases cellular immune responses.

12 for other products, please visit the Wako Online Catalog www.e-reagent.com 3. Inhibitor Cocktail Sets Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Phosphatase Inhibitor Cocktail Solution I (×100)

167-24381 1 mL for Cellbiology - - - Keep at 2-10℃. 5 phosphatase inhibitor mixture [Inhibition Target] serine/threonine phosphatases, tyrosine phosphatases, and dual-specificity phosphatases [Composition] sodium fluoride, sodium orthovanadate, sodium pyrophosphate,β -glycerophosphate, and sodium molybdate

Phosphatase Inhibitor Cocktail Solution II (×100)

160-24371 1 mL for Cellbiology - - - Keep at 2-10℃. 5 phosphatase inhibitor mixture [Inhibition Target] acid phosphatases; alkaline phosphatases; tyrosine phosphatases [Composition] sodium fluoride, sodium tartrate, sodium orthovanadate, imidazole, and sodium molybdate

Protease Inhibitor Cocktail Set I, Animal-derived-free (for general use) (x 100), Lyophilized

165-26021 for 1 mL for Cellbiology - - - Keep at -20℃. for 1 mL x 5 161-26023 3.

5 inhibitor mixture solution. It replaces aprotinin from bovine lung with recombinant aprotinin produced with no animal by-products. Inhibitor Cocktail Sets [Inhibition Target] a wide variety of proteases and esterases.

Protease Inhibitor Cocktail Set III, DMSO Solution (EDTA free) (x 100)

163-26061 1 mL for Cellbiology - - - Keep at -20℃. 169-26063 1 mL x 5 6 inhibitor mixture solution being suitable for experiments targeted on metal-binding proteins in mammalian cells, tissue extracts, and bacterial extracts. It does not contain EDTA or other metalloproteinase inhibitors. [Inhibition Target] a wide range of proteases including aminopeptidases.

Protease Inhibitor Cocktail Set III, DMSO Solution, Animal-derived-free (EDTA free) (×100)

160-26071 1 mL for Cellbiology - - - Keep at -20℃. 166-26073 1 mL x 5 6 inhibitor mixture solution being suitable for experiments targeted on metal-binding proteins in mammalian cells, tissue extracts, and bacterial extracts. It inhibits a wide range of proteases including aminopeptidases. It does not contain EDTA or other metalloproteinase inhibitors. It replaces aprotinin from bovine lung with recombinant aprotinin produced with no animal by-products.

Protease Inhibitor Cocktail Set IV, DMSO Solution (for Fungal and Yeast) (×100)

167-26081 1 mL for Cellbiology - - - Keep at -20℃. 163-26083 1 mL x 5 4 inhibitor mixture DMSO solution, being suitable for use in mold and yeast extracts. [Inhibition Target] serin proteases, cystein proteases, metalloproteases, asparatic proteases.

Protease Inhibitor Cocktail Set V (EDTA free) (×100), Lyophilized

162-26031 for 1 mL for Cellbiology - - - Keep at -20℃. 168-26033 for 1 mL x 5 4 inhibitor mixture solution, being suitable for experiments targeted on metal-binding proteins and recombinant proteins. In addition, also useful for metal-affinity column chromatography. [Inhibition Target] serin proteases, cystein proteases, metalloproteases, asparatic proteases.

Protease Inhibitor Cocktail Set VI, DMSO Solution (for Plant) (×100)

164-26091 1 mL for Cellbiology - - - Keep at -20℃. 160-26093 1 mL x 5 6 inhibitor mixture solution, being suitable for plant extracts. [Inhibition Target] serin proteases, cystein proteases, trypsin-like proteases, aminopeptidase B, leucine aminopeptidase, asparatic proteases, metalloproteases.

Protease Inhibitor Cocktail Set VII, DMSO Solution (for Histidine-tagged Protein) (× 100)

167-26101 1 mL for Cellbiology - - - Keep at -20℃. 163-26103 1 mL x 5 EDTA-free 5 inhibitor mixture solution, being suitable for purification of histidine-tagged proteins. [Inhibition Target] serin proteases, cystein proteases, aminopeptidase B, leucine aminopeptidase, asparatic proteases, metalloproteases.

13 4. Calcium Signaling related Inhibitors Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Alendronate Sodium Salt Trihydrate, 97.0+ % (HPLC)

012-22661 100 mg for Pharmacology 121268-17-5 Water IC50 = 10 μM Keep at -20℃. 018-22663 500 mg Research This product is a bisphosphonate compound that is selectively distributed in the calcified bone surface to which the osteoclasts are attached. It is released under an acid environment created by the osteoclasts, taken in the cells, and inhibits the bone resorption activity. The inhibition of the bone resorption is considered to be caused by apoptosis induction effect of the osteoclasts and direct suppression of bone resorption of the osteoclasts.

(-)-Blebbistatin, 98.0+ % (HPLC)

021-17041 1 mg for Cellbiology 856925-71-8 DMSO (5 mg/mL) - Keep at -20℃. 027-17043 5 mg Specific inhibitor of myosin II. It inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly in the vertebrate cell divisions. It has been reported to block blebbing and apoptosis and increases the colony forming rate when human ES cells are dispersed to single cells from a colony.

Calpain Inhibitor 2, 95.0+ % (HPLC)

038-19811 10 mg for Cellbiology 110115-07-6 Ethanol, methanol - Keep at -20℃. This product inhibits neutral cysteine proteinases such as calpain 1, calpain 2, cathepsin B and cathepsin L. It is also a weak inhibitor of proteasomes.

Chlorpromazine Hydrochloride, 99.0+ % (Titration)

033-10581 10 g for Biochemistry 69-09-0 Water, ethanol IC50 = 25 μM Keep below 25℃. Chlorpromazine Hydrochloride is a phenothiazine neuroleptic which induces tranquilization, analgesia, lowering of body temperature by inhibiting the hypothalamic thermoregulatory mechanism, antiemesis by inhibiting CTZ of the medulla oblongata, inhibition of conditioned

related Inhibitors related avoidance response, and hypnosis, as well as an antidopaminergic. This reagent potently blocks α-adrenergic receptors. Its mode of action 4. Calcium Signaling 4. in the biogenic system is inhibition of calmodulin, similar to trifluoperazine.

Cyclopiazonic Acid, 98.0+ % (HPLC)

2+ 030-17171 5 mg for Biochemistry 18172-33-3 Methanol IC50 of Ca : 0.2 μM; ATPase: 0.35 μM Keep at -20℃. Mycotoxin (fungal toxin). It is a specific inhibitor of Ca2+-ATPase.

2,5-Di-t-butylhydroquinone, 99.0+ % (Capillary GC)

040-24681 100 mg Benzene， ethanol， for Biochemistry 88-58-4 acetone， IC50 = 66.7 ± 2.1 μM Keep at RT. 046-24683 1 g carbon bisulfide

This product inhibits the Ca2+ ATPase of the sarcoplasmic reticulum and does not act on the plasma membrane Ca2+ pump.

E-64d, 97.0+ % (HPLC)

054-08021 1 mg for Cellbiology 88321-09-9 Methanol IC50 = 0.5 μM Keep at -20℃. 050-08023 5 mg Membrane-permeable cysteine protease inhibitor which is an analog of E-64, a cysteine protease inhibitor isolated from Aspergillus japonicas. Esters are hydrolyzed when permeated through the membrane and E-64d is considered to change to an activated form, E-64c. This reagent inhibits calpain and cathepsin. It is used in combination with pepstatin A in order to prevent degradation of LC3-II in the autophagosome inner membrane during autophagy.

Fluphenazine Dimaleate, 98.0+ % (Titration)

Dilute hydrochloric 061-01751 1 g for Biochemistry 3093-66-1 - Keep at 2-10℃. acid Phenothiazine neuroleptic. It is a calmodulin inhibitor, similar to chlorpromazine.

14 for other products, please visit the Wako Online Catalog www.e-reagent.com Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Mastoparan

139-16511 1 mg for Cellbiology 72093-21-1 Water IC50 = 15 μM Keep at -20℃. Amphiphilic peptide isolated as an ingredient of hornet poison. It activated directly pertussis toxin-sensitive G protein (Gi, G0) by a mechanism resembling G protein-conjugate type receptors. It also acts as a calmodulin antagonist.

MG-132, 80.0+ % (HPLC)

139-16251 1 mg for Cellbiology 133407-82-6 Methanol IC50 = 1.25 μM Keep at -20℃. 135-16253 5 mg Membrane-permeable peptide aldehyde protease inhibitor which reversibly inhibits the chymotrypsin-like activity of 26S proteasome.

Quinacrine Dihydrochloride Dihydrate, 95.0+ % (HPLC)

171-00502 25 g for Biochemistry 69-05-6 Water, ethanol IC50 = 4.4 μM Keep below 25℃. Antimalarial; calmodulin inhibitor; phospholipase inhibitor

Suramin Sodium, 98.0+ % (HPLC)

199-10613 100 mg for Biochemistry 129-46-4 Water IC50 = 4.9 ± 1.2 μM Keep at RT. 193-10611 200 mg This product inhibits Ca2+ ATPase of the sarcoplasmic reticulum. It also blocks growth factors, including EGF from binding to the cell envelope. 4. Calcium Signaling related Inhibitors Thapsigargin

209-17281 1 mg for Cellbiology 67526-95-8 Acetonitrile IC50 = 0.13 ± 0.02 μM Keep at -20℃. 205-17283 5 mg Thapsigargin is an endoplasmic reticulum Ca2+-ATPase(SERCA) inhibitor which inhibits all SERCA isoforms. The endoplasmic reticulum uptake of calcium ion is blocked causing releasing of calcium ions from the endoplasmic reticulum to the cytoplasm, by irreversible inhibition of SERCA activity. 5. Ion Channel-related Blockers

5. Ion Channel-related Blockers (1) Calcium Channel Blockers Product Name

Wako Cat. No. Pkg. Size Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

ω-Agatoxin IVA (P-type Blocker), from Funnel Web Spider, Agelenopsis aperta

Peptide Institute, Inc. 339-42561 0.1 mg 145017-83-0 - - Keep at -20℃. (4256-s) Channel selective blockers with Cys-Cys binding. Peptidic ion channel blockers.

ω-Agatoxin TK (P-type Blocker)

Peptide Institute, Inc. 339-42941 0.1 mg 145017-83-0 - - Keep at -20℃. (4294-s) Channel selective blockers with Cys-Cys binding. Peptidic ion channel blockers.

Agelenin, from Spider, Agelena opulenta

Peptide Institute, Inc. 330-42471 0.1 mg - - - Keep at -20℃. (4247-s) Channel selective blockers with Cys-Cys binding. Peptidic ion channel blockers.

15 Product Name

Wako Cat. No. Pkg. Size Grade/Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

Amlodipine, 98.0+ % (HPLC)

011-24951 100 mg for Cellbiology 88150-42-9 - - Keep at RT. 017-24953 1 g L-type calcium channel blocker with a hypotensive action. It acts on cardiovascular system, including facilitation of NO production, inhibition of oxidative stress, and inhibition of adhesion of monocytes to the endothelium. In addition, it acts for a prolonged period compared to other similar calcium channel blockers.

2,3-Butanedione Oxime

045-00652 25 g Wako Special Grade 57-71-6 Water, ethanol IC50 = 15.3 mM Keep at RT. 047-00651 100 g 2,3-Butanedione Oxime has phosphatase activity and inhibits contraction of skeletal muscles and cardiac muscles.

Calcicludine (L-type Blocker), 99.0+ % (HPLC), from Green Mamba, Dendroaspis angusticeps

Peptide Institute, Inc. 337-43101 0.1 mg 178037-96-2 - - Keep at -20℃. (4310-s) Neuronal L-type Ca2+ Channel Blocker. Peptidic ion channel blockers.

Calciseptine (L-type Blocker), from Black mamba, Dendroaspis polylepis polylepis

Peptide Institute, Inc. 332-42551 0.1 mg - - - Keep at -20℃. (4255-s) L-type Ca2+ Channel Blocker. Peptidic ion channel blockers.

Cinnarizine, 98.0+ % (Titration)

Acetone, ether,

030-13592 25 g for Biochemistry 298-57-7 chloroform, IC50 = 0.75 μM Keep at RT. benzene Cinnarizine has antihistaminic and vasodilatory activities, improves cerebral blood flow impairment, and exerts Ca2+ channel inhibitory activity.

ω-Conotoxin GVIA (N-type Blocker), from Marine Snail, Conus geographus

Peptide Institute, Inc. 336-41611 0.5 mg 106375-28-4 - - Keep at -20℃. (4161-v) N-type Ca2+ Channel Blocker. Peptidic ion channel blockers.

ω-Conotoxin MVIIA (N-type Blocker), 99.0+ % (HPLC) from Marine snail, Conus magus

Peptide Institute, Inc. 338-42891 0.5 mg 107452-89-1 - - Keep at -20℃. (4289-v)

Blockers Reversible N-type Ca2+ Channel Blocker. Peptidic ion channel blockers. Ion Channel-related Ion Channel-related ω-Conotoxin MVIIC (P/Q-type Blocker), 99.0+ % (HPLC), from Marine Snail, Conus magus 5. 5.

Peptide Institute, Inc. 332-42833 0.5 mg (4283-v) 147794-23-8 - - Keep at -20℃. Peptide Institute, Inc. 336-42831 0.1 mg (4283-s) P/Q-type Ca2+ Channel Blocker. Peptidic ion channel blockers.

ω-Conotoxin SVIB (N-type Blocker), 99.0+ % (HPLC), from Marine Snail, Conus striatus

Peptide Institute, Inc. 333-42841 0.5 mg 150433-82-2 - - Keep at -20℃. (4284-v) N-type Ca2+ Channel Blocker. Peptidic ion channel blockers.

Diltiazem Hydrochloride, 98.0+ % (Titration)

047-20311 1 g Formic acid, water, for Biochemistry 33286-22-5 IC50 = 4.5 μM Keep at 2-10℃. 043-20313 5 g ethanol, chloroform Therapeutic substance for circulatory diseases such as hypertension, angina and arrhythmia. It inhibits voltage-dependent calcium channels and reduces the inflow of Ca2+ from extracellular to intracellular parts. Specific calcium antagonists include nifedipine, verapamil and diltiazem.

16 for other products, please visit the Wako Online Catalog www.e-reagent.com Product Name

Wako Cat. No. Pkg. Size Grade/Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

Kurtoxin, 98.0+ % (HPLC), from Scorpion, Parabuthus transvaalicus

Peptide Institute, Inc. 338-43751 0.1 mg - - - Keep at -20℃. (4375-s) T-type Ca2+ channel blocker. Peptidic ion channel blockers.

Nicardipine Hydrochloride, 99.0+ % (HPLC)

145-06381 1 g Methanol, for Biochemistry 54527-84-3 IC50 = 2.56 μM Keep at RT. 141-06383 5 g chloroform It inhibits voltage-dependent calcium channels and reduces the inflow of Ca2+ from extracellular to intracellular parts.

Nitrendipine, 98.0+ % (HPLC)

Chloroform, 142-06411 200 mg for Biochemistry 39562-70-4 IC50 = 23 μM Keep at RT. acetonitrile It inhibits voltage-dependent calcium channels and reduces the inflow of Ca2+ from extracellular to intracellular parts. It dilates peripheral vessels and coronary arteries and has hypotensive and anti-angina actions. Its hypotensive action is comparable to nifedipine, and the action lasts longer than nifedipine.

PLTX-II, 99.0+ % (HPLC), from Spide, Plectreurys tristes

Peptide Institute, Inc. 331-43001 0.1 mg - - - Keep at -20℃. (4300-s) Presynaptic Ca2+ Channel Blocker

ProTx-1, 97.0+ % (HPLC), from Tarantula, Thrixopelma pruriens

Peptide Institute, Inc. 338-44091 0.1 mg - - - Keep at -20℃. (4409-s) T-Type Ca2+ Channel / Na+ Channel / K+ Channel Blocker (Gating Modifier)

Ryanodine

185-02821 1 mg for Cellbiology 15662-33-6 Methanol - Keep at -20℃. Signal transduction Ca2+ channel Inhibitor Ryanodine is an alkaloid isolated from Ryania speciosa Vahl. It acts to increase calcium permeability by binding to the arcoplasmic reticulum calcium channel.

SNX-482, 99.0+ % (HPLC), from Tarantula, Hysterocrates gigas 5. Ion Channel-related Peptide Institute, Inc.

338-43631 0.1 mg 203460-30-4 - - Keep at -20℃. Blockers (4363-s) Class E (R-type) Ca2+ Channel Blocker

Verapamil Hydrochloride, 98.0+ % (Titration)

222-00781 1 g for Biochemistry 152-11-4 Ethanol IC50 = 0.3 μM Keep at RT. 228-00783 10 g Verapamil HCl directly affects the smooth muscle of blood vessels and the heart and is a Ca2+ antagonist. It also promotes effects of tumoricidal drugs and is used in research concerning the mechanism of calcium antagonists.

(2) Potassium Channel Blockers Product Name

Wako Cat. No. Pkg. Size Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

Apamin, 99.0+ % (HPLC), from Honeybee, Apis mellifera

Peptide Institute, Inc. 336-42571 0.5 mg 24345-16-2 - - Keep at -20℃. (4257-v) Small conductance Ca2+-activated K+ channel blocker

Charybdotoxin, 99.0+ % (HPLC), from Scorpion, Leiurus quinquestriatus var. hebraeus

Peptide Institute, Inc. 338-42271 0.1 mg 95751-30-7 - - Keep at -20℃. (4227-s) Ca2+-activated K+ channel blocker

17 Product Name

Wako Cat. No. Pkg. Size Grade/Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

Dendrotoxin 1, 99.0+ % (HPLC), from black mamba, Dednroaspis polylepis polylepis

Peptide Institute, Inc. 339-43301 0.1 mg 107950-33-4 - - Keep at -20℃. (4330-s) Voltage-dependent K+ channel blocker

E-4031 n-Hydrate, 98.0+ % (HPLC)

059-08451 10 mg Native guinea pig HERG channel: IC50 = for Cellbiology - Water Keep at -20℃. 055-08453 50 mg 397 nM E-4031 is a HERG potassium channel blocker with antiarrhythmic action (class III ). It selectively inhibits Ikr, a rapid component of the delayed rectifier K current, during repolarization after muscle cells are depolarized.

Glibenclamide, 98.0+ % (Titration)

078-03881 5 g for Biochemistry 10238-21-8 DMF IC50 = 0.1 μM Keep at RT. 076-03882 25 g Sulfonylurea hypoglycemic substance. It blocks ATP-dependent K+ channel of the pancreas to increase intracellular Ca2+, thus increasing insulin secretion. It pharmacologically antagonizes the action of K+ channel-opening agents in the heart and blood vessels.

Guangxitoxin-1E, 97.0+ % (HPLC), from Tarantula, Plesiophrictus guangxiensis sp. nov.

Peptide Institute, Inc. 334-44331 0.1 mg - - - Keep at -20℃. (4433-s) Kv2.1/Kv2.2 channel blocker / Enhancer of glucose-dependent insulin secretion

Iberiotoxin, 99.0+ % (HPLC), from Scorpion, Buthus tamulus

Peptide Institute, Inc. 330-42351 0.1 mg 129203-60-7 - - Keep at -20℃. (4235-s) Highly selective and potent high conductance Ca2+-activated K+ channel blocker

Kaliotoxin (1-37), 99.0+ % (HPLC), from Scorpion, Androctonus mauretanicus mauretanicus

Peptide Institute, Inc. 330-42591 0.1 mg 145199-73-1 - - Keep at -20℃. (4259-s) High conductance Ca2+-activated K+ channel blocker

Margatoxin【 MgTX】, 99.0+ % (HPLC)

Peptide Institute, Inc. 331-42901 0.1 mg 145808-47-5 - - Keep at -20℃. (4290-s)

Blockers Voltage-dependent K+ channel blocker (specific for Kv1.3 channel )

Ion Channel-related Ion Channel-related MCD-Peptide, 99.0+ % (HPLC), from Honeybee, Apis mellifera 5. 5.

Peptide Institute, Inc. 333-42581 0.5 mg 32908-73-9 - - Keep at -20℃. (4258-v) Voltage-dependent K+ channel blocker

Scyllatoxin, 99.0+ % (HPLC), from Scorpion, Leiurus quinquestriatus hebraeus

Peptide Institute, Inc. 333-42601 0.1 mg 116235-63-3 - - Keep at -20℃. (4260-s) Small conductance Ca2+-activated K+ channel blocker

Stichodactyla Toxin, 99.0+ % (HPLC), from Sea Anemone, Stichodactyla helianthus

Peptide Institute, Inc. 334-42871 0.1 mg - - - Keep at -20℃. (4287-s) Voltage-dependent K+ channel (A channel) blocker

Tertiapin, 99.0+ % (HPLC), from Apis mellifera

Peptide Institute, Inc. 335-43641 0.1 mg 58694-52-3 - - Keep at -20℃. (4364-s) Potent blocker of inward-rectifier +K channels such as ROMK1 and GIRK1/4 at 2.5-10 nM.

18 for other products, please visit the Wako Online Catalog www.e-reagent.com Product Name

Wako Cat. No. Pkg. Size Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

Tityustoxin Kα, 99.0+ % (HPLC), from Scorpion, Tityus serrulatus

Peptide Institute, Inc. 338-43131 0.1 mg 39465-37-7 - - Keep at -20℃. (4313-s) Voltage-dependent K+ channel (A channel) blocker

(3) Sodium Channel Blockers Product Name

Wako Cat. No. Pkg. Size Grade/Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

Clotrimazole, 98.0+ % (HPLC)

035-16021 5 g Ethanol, chloroform, for Biochemistry 23593-75-1 IC50 = 1.8 μM Keep at RT. 033-16022 25 g carbon tetrachloride It exhibits bactericidal action by destroying cytoplasmic membranes of fungi.

μ-Conotoxin G3B, 99.0+ % (HPLC), from Marine Snail, Conus geographus

Peptide Institute, Inc. 332-42171 0.5 mg 140678-12-2 - - Keep at -20℃. (4217-v) Na+ channel blocker: Specific for skeletal muscle

μ-Conotoxin GS, 95.0+ % (HPLC), from Marine Snail, Conus geographus

Peptide Institute, Inc. 334-42631 0.5 mg 171358-00-2 - - Keep at -20℃. (4263-v) Selective blocker of Na+ channels of skeletal muscles.

μ-Conotoxin SIIIA, 99.0+ % (HPLC), from Marine Snail, Conus striatus

Peptide Institute, Inc. 339-44401 0.5 mg 877860-32-7 - - Keep at -20℃. (4440-v) Tetrodotoxin-resistant Na+ channel blocker with analgesic activity

Huwentoxin-IV, 97.0+ % (HPLC), from Chinese Bird Spider, Ornithoctonus huwena 5. Peptide Institute, Inc. 330-44551 0.1 mg - - - Keep at -20℃. Ion Channel-related (4455-s) Blockers Neuronal tetrodotoxin-sensitive Na+-channel blocker

Omeprazole, 98.0+ % (HPLC)

150-02091 10 g Dichloromethane, for Biochemistry 73590-58-6 IC50 = 4.2 μM Keep at -20℃. 158-02092 25 g methanol Eradicating agent for Helicobacter pylori (HP). Selective inhibitor of gastric H+, K+ ATPase (proton pump), and used as a marker to test the susceptibility of HP to this product in vitro.

ProTx-II, 99.0+ % (HPLC)

Peptide Institute, Inc. 335-44501 0.1 mg - - - Keep at -20℃. 4450-s Na+ channel (especially Nav1.7) / Ca2+ channel blocker (gating modifier)

(4) Transient Receptor Potential (TRP) Channel Blockers Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

AMG 9810, 98.0+ % (HPLC)

015-25071 10 mg for Cellbiology 545395-94-6 Ethanol - Keep at 2-10℃. 011-25073 50 mg Antagonist of transient receptor potential vanilloid 1 (TRPV1). TRPV1 is one of the TRP channels cloned as a capsaicin receptor, functions as a pain receptor, and is activated by capsaicin, heat, and protons. It also inhibits the activation of TRPV1 by heat and protons, besides capsaicin.

19 Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

AP 18, 98.0+ % (HPLC)

014-25161 10 mg Ethanol for Cellbiology 55224-94-7 - Keep at -20℃. 010-25163 50 mg (10 mg/2 mL) Selective TRPA1 (transient receptor potential ankyrin 1) inhibitor. TRPA1 is involved in pain transmission, and its involvement in respiratory depression has also been reported.

2-APB, 98.0+ % (HPLC)

013-24911 100 mg for Cellbiology 524-95-8 Ethanol - Keep at -20℃. 019-24913 500 mg Inhibitor of inositol triphosphate (IP3) receptors. It can also block TRP channels TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2. At high concentrations, it can activate TRPV1, TRPV2 and TRPV3.

BCTC, 98.0+ % (HPLC)

027-18241 10 mg for Cellbiology 393514-24-4 Ethanol - Keep at -20℃. 023-18243 50 mg TRPV1 antagonist. It inhibits the activation of TRPV1 by capsaicin and acids.

Capsazepine, 98.0+ % (HPLC)

037-23171 10 mg for Cellbiology 138977-28-3 Ethanol - Keep at 2-10℃. 033-23173 50 mg TRPV1 antagonist. Capsaicin analog.

HC-030031, 98.0+ % (HPLC)

086-09961 10 mg for Cellbiology 349085-38-7 DMSO - Keep at RT. 082-09963 50 mg Selective TRPA1 (transient receptor potential ankyrin 1) inhibitor.

Olvanil, 98.0+ % (HPLC)

154-03231 10 mg for Cellbiology 58493-49-5 Ethanol - Keep at -20℃. 150-03233 50 mg It demonstrated to block intracellular accumulation of Anandamide through interaction with the anandamide transporter at concentrations similar to those needed for TRPV1 activation. Also inhibits FAAH (fatty acid amide hydrolase). It also acts as a potent TRPV1 angonist and a CB1 agonist.

RN-1747, 98.0+ % (HPLC) Blockers 183-02981 10 mg Ion Channel-related Ion Channel-related for Cellbiology 1024448-59-6 DMSO - Keep at 2-10℃. 5. 5. 189-02983 50 mg TRPM8 antagonist. It also acts as a TRPV4 (transient receptor potential vanilloid 4)-selective agonist.

Ruthenium Red

184-00331 100 mg Wako Special Grade 11103-72-3 Water - Keep at RT. 180-00333 1 g TRPA1 antagonist.

SB-366791, 98.0+ % (HPLC)

193-17431 10 mg for Cellbiology 472981-92-3 Ethanol - Keep at -20℃. 199-17433 50 mg TRPV1 antagonist, which inhibits the activation of TRPV1 by capsaicin and heat. It has been reported that it does not inhibit activation by protons.

20 for other products, please visit the Wako Online Catalog www.e-reagent.com (5) Acid-Sensing Ion Channel Blockers Product Name

Wako Cat. No. Pkg. Size Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

APETx2, 99.0+ % (HPLC)

Peptide Institute, Inc. 331-44721 0.1 mg 713544-47-9 - - Keep at -20℃. (4472-s) Selective blocker of acid-sensing ion channel blocker, ASIC3

Psalmotoxin 1, 97.0+ % (HPLC), from South American Tarantula, Psalmopoeus cambridgei (Trifluoroacetate Form)

Peptide Institute, Inc. 338-44351 0.1 mg - - - Keep at -20℃. (4435-s) Selective blocker of ASIC1a

(6) Nicotinic Acetylcholine Receptor Blockers Product Name

Wako Cat. No. Pkg. Size Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

α-Conotoxin G1, 97.0+ % (HPLC), from Marine Snail, Conus geographus (Hydrochloride Form)

Peptide Institute, Inc. 337-41261 0.5 mg 76862-65-2 - - Keep at -20℃. (4126-v) Nicotinic acetylcholine receptor blocker

α-Conotoxin ImI, 99.0+ % (HPLC), from Marine Snail, Conus imperialis

Peptide Institute, Inc. 334-43111 0.5 mg 156467-85-5 - - Keep at -20℃. (4311-v) Nicotinic acetylcholine receptor blocker in central nervous system

α-Conotoxin M1, 99.0+ % (HPLC), from Marine Snail, Conus magus

Peptide Institute, Inc. 337-41401 0.5 mg 88217-10-1 - - Keep at -20℃. (4140-v) Nicotinic acetylcholine receptor blocker

α-Conotoxin SI, 99.0+ % (HPLC), from Marine Snail, Conus striatus 5. Ion Channel-related Peptide Institute, Inc. 335-42281 0.5 mg 133605-58-0 - - Keep at -20℃. (4228-v) Blockers Nicotinic acetylcholine receptor blocker

(7) Other Blockers Product Name

Wako Cat. No. Pkg. Size Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

Chlorotoxin, 99.0+ % (HPLC), from Scorpion, Leiurus quinquestriatus

Peptide Institute, Inc. 339-42821 0.5 mg 163515-35-3 - - Keep at -20℃. (4282-v) Small-conductance Cl- channel blocker

GsMTx-4, 99.0+ % (HPLC)

Peptide Institute, Inc. 336-43931 0.1 mg - - - Keep at -20℃. (4393-s) Inhibitor for cation-selective stretch-activated channels / Atrial fibrillation inhibiting peptide

Purotoxin-1, 99.0+ % (HPLC)

Peptide Institute, Inc. 334-44571 0.1 mg - - - Keep at -20℃. (4457-s) P2X3 purinoreceptor inhibitor

21 6.G-protein Signaling and Second Messenger-related Inhibitors Product Name

Wako Cat. No. Pkg. Size Grade/Manufacturer CAS No. Soluble in IC50 Storage Condition Summary

Andrographolide, 98.0+ % (HPLC)

014-15271 500 mg for Biochemistry 5508-58-7 Methanol, acetone IC50 = 5.6 ± 0.7 μM Keep at 2-10℃. It is reported to suppress the decrease of glutathion and to counteract toxic liver damage caused by substances such as carbontetrachloride and t-butylhydroperoxide.

BAY 11-7085, 98+ % (NMR)

020-14331 10 mg for Biochemistry 196309-76-9 Ethanol, acetone IC50 = 10 μM Keep at -20℃. 026-14333 25 mg

Inhibitor of cytokine-induced IκBα phosphorylation and decreases expression of NFκB and adhesion molecule. It also exhibits strong antiinflammatory activity.

8-(4-Chlorophenylthio)adenosine 3',5'-(Cyclic)monophosphate Sodium Salt, 98.0+ % (HPLC)

039-18121 10 mg for Biochemistry 93882-12-3 Water IC50 of PKA: 900 nM; PKG: 25 μM Keep at -20℃. 035-18123 100 mg Cell permeable cAMP analog, used as an activator of cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG).

Curcumin

038-04921 1 g IC50 of 5-Lipoxygenase: 5 - 10 μM, Wako Special Grade 458-37-7 Ethanol, acetic acid Keep at RT. 036-04922 25 g COX ≦ 100 μM Inhibitor of 5-lipoxygenase and cyclooxygenase.

Isotetrandrine

Kaken Shoyaku Co., 306-01771 25 mg 477-57-6 - - Keep at 2-10℃. Ltd. A biscoclaurine alkaloid inhibitor of G protein activation of PLA2

LY-83583, 94+ % (TLC)

IC50 of soluble Guanylate cyclase in human 128-04691 5 mg for Biochemistry 91300-60-6 Ethanol, acetone platelets: 2 μM; leukotriene synthesis in Keep at -20℃. guinea pig lung and rat celiac cells: 1.8 μM It decreases the concentration of cellular cGMP through the inhibition of guanylate cyclase.

NS2028, 98.0+ % (HPLC)

149-06921 5 mg for Biochemistry 204326-43-2 Water, ethanol - Keep at -20℃. Selective inhibitor of soluble guanylate cyclase (sGC) that is sensitive to NO. It does not inhibit sGC activity enhanced by YC-1 or CO.

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one【 ODQ】, 97.0+ % (HPLC)

153-01981 10 mg for Biochemistry 41443-28-1 Ethanol, acetone - Keep at 2-10℃.

G-protein Signaling and Second 159-01983 25 mg Messenger-related Inhibitors Messenger-related

6. 6. It inhibits the guanylate cyclase activity of NO produced by NOS rather than NO synthase (NOS), and controls the increase in cGMP.

Pentoxifylline, 98.0+ % (Titration)

Methanol, ethanol, 160-18761 10 g for Biochemistry 6493-05-6 TNFα: IC50 = 100 μM Keep at RT. acetone, water TNF-α synthesis inhibior and phosphodiesterase inhibitor

22 for other products, please visit the Wako Online Catalog www.e-reagent.com Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Rolipram, 98+ % (TLC)

180-01411 10 mg for Biochemistry 61413-54-5 Ethanol IC50 = 20 μM Keep at 2-10℃.

This cAMP diphosphodiesterase inhibitor selectively inhibits phosphodiesterase IV, a type of isozyme. Improvement of arthritis (in rats with collagen II induced arthritis) has been reported.

7.Neurotransmitter Inhibitors (1) Glutamate Receptor Antagonists Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

DL-2-Amino-4-phosphonobutyric Acid, 98.0+ % (HPLC)

Hydrochloric acid, 013-22071 100 mg for Cellbiology 6323-99-5 - Keep at 2-10℃. water NMDA-type glutamate receptor antagonists.

L-2-Amino-4-phosphonobutyric Acid, 98.0+ % (HPLC)

016-22083 10 mg for Cellbiology 23052-81-5 Water EC50 = 16.0 μM Keep at 2-10℃. Selective agonist for group III metabotropic glutamate receptors ( mgluR4, mgluR6).

D(-)-2-Amino-5-phosphonovaleric Acid 【 D-AP5】

015-18481 10 mg for Biochemistry 79055-68-8 Hydrochloric acid IC50 = 3.7 ± 0.32 μM Keep at RT. A neural amino acid. It is a potent antagonist of the NMDA-type receptor, which is one of the ion-channel glutamine receptors.

DL-2-Amino-5-phosphonovaleric Acid 【 DL-AP5】

018-18471 10 mg for Biochemistry 76326-31-3 Water IC50 = 90 μM Keep at RT. A neural amino acid. It is a potent antagonist of the NMDA-type receptor, which is one of the ion-channel glutamine receptors.

(R)-CPP

031-22091 1 mg for Cellbiology 126453-07-4 Water (10 mg/mL) - Keep at RT. 037-22093 5 mg Highly potent glutaminergic NMDA receptor antagonist. It exhibits a higher activity than racemic CPP. It is selective to NR2A in NMDA receptor.

Dextromethorphan Hydrobromide Monohydrate, 98.0+ % (Titration)

041-21551 5 g Methanol, acetic for Biochemistry 6700-34-1 - Keep below 25℃. 049-21552 25 g acid, ethanol 6.

NMDA receptor antagonist. Messenger-related Inhibitors G-protein Signaling and Second Diazoxide, 99.0+ % (HPLC)

047-23133 250 mg for Biochemistry 364-98-7 DMSO - Keep at RT. 041-23131 1 g Desensitization blocker of AMPA receptor.

DL-AP7, 98.0+ % (1H- NMR)

041-31941 5 mg for Cellbiology 85797-13-3 NaOH soln. IC50 = 11.1 ± 2.1 μM Keep at RT. 7. Neurotransmitter A neural amino acid. It is a potent antagonist of the NMDA-type receptor, which is one of the ion-channel glutamine receptors. Inhibitors DNQX, 95+ % (TLC)

044-26301 50 mg for Biochemistry 2379-57-9 Methanol - Keep at -20℃. AMPA/Kainate receptor antagonist

23 Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Evans Blue

056-04061 5 g Practical Grade 314-13-6 Water IC50 = 87 nM Keep at RT. 054-04062 25 g AMPA/Kainate receptor antagonist.

Felbamate, 98.0+ % (HPLC)

060-05861 10 mg for Cellbiology 25451-15-4 DMSO, ethanol IC50 = 0.78 ± 0.07 mM Keep at -20℃. 066-05863 50 mg Allosteric antagonist of NR2B subunit of glutaminergic NMDA receptor and exhibits strong anticonvulsant action. It also has a property as a γ-aminobutyric acid (GABA) receptor agonist.

Joro Spider Toxin JSTX-3, 98.0+ % (HPLC)

104-00051 0.1 mg for Biochemistry 112163-33-4 Water IC50 = 1.7 μM Keep at 2-10℃. Toxin isolated from Joro Spider poison gland, paralyzes the movement of arthropods (insects, crustaceans, etc.). It irreversibly blocks excitatory transmissions of neurons and muscles by glutamate released from the synaptic terminal of motor neurons. It acts selectively on quisqualate glutamate receptor.

Loperamide Hydrochloride

129-05721 5 g for Pharmacology 34552-83-5 Methanol, ethanol IC50 = 0.9 ± 0.2 μM Keep at RT. 127-05722 25 g Research NMDA receptor antagonist. It reduces Ca2+ flow. Loperamide Hydrochloride is a NMDA receptor antagonist that reduces the flow of 2+Ca . It is an antidiarrheal agent that inhibits both peristaltic movement of the intestinal tract and secretion, and enhances absorption, via opioid receptor in the intestinal tract.

(+)-MCPG, 99.0+ % (HPLC)

135-16111 2 mg for Cellbiology 150145-89-4 0.1M NaOH IC50 = 272 μM Keep at 2-10℃. 131-16113 10 mg Competitive antagonist for group 1 (mGluR1, mGluR5) and group 2 (mGluR2, mGluR3) metabotropic glutamate receptors. It is an active enantiomer of (±)-MCPG. Memantine Hydrochloride

132-16981 25 mg for Cellbiology 41100-52-1 Water IC50 = 1.2 ± 0.2 μM Keep at RT. 138-16983 100 mg This is a glutaminergic NMDA receptor antagonist and stimulates dopamine release by binding to the ion channel site. It is used in researches on Parkinson's disease, spasms, Alzheimer's disease and so on.

(+)-MK 801 Maleate, 98.0+ % (HPLC)

130-17381 10 mg for Cellbiology 77086-22-7 Methanol Ki = 30.5 ± 1.5 nM Keep at 2-10℃. 136-17383 50 mg Selective antagonist of NMDA glutamate receptor. It inhibits calcium ion influx across cell membranes by binding mainly to the pore of the ion channel opened upon the ligand binding. It is known as an anti-ischemic agent.

NBQX Disodium Salt, 98.0+ % (HPLC)

147-08661 10 mg for Cellbiology 479347-86-9 Water - Keep at 2-10℃. Water-soluble NBQX. NBQX is a potent and competitive AMPA/kainate receptor antagonist.

NBQX, 99+ % (TLC)

148-06751 10 mg for Biochemistry 118876-58-7 Acetone IC50 = 0.90 μM Keep at 2-10℃. Antagonist of the AMPA/kainate receptor.

Pentamidine Isethionate, 98.0+ % (HPLC)

166-25191 50 mg for Cellbiology 140-64-7 Water IC50 = 2 - 18 μM Keep at -20℃. This substance exhibits nerve protection activity and inhibits homeostatic NO synthase in the brain. It is an antagonist to NMDA glutamate Inhibitors receptor. It inhibits glucose metabolism and protein synthesis in Pneumocystis carinii. 7. Neurotransmitter Neurotransmitter 7.

24 for other products, please visit the Wako Online Catalog www.e-reagent.com Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Spermine, 95.0+ % (Titration)

198-09811 250 mg for Biochemistry 71-44-3 Water, chloroform IC50 = 170 μM Keep at 2-10℃. 194-09813 1 g Agonist during depolarization and antagonist during hyperpolarization.

(2) Inhibitors of Angiotensin Conversion Enzyme Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Benazepril Hydrochloride, 97.0+ % (HPLC)

024-14091 1 g for Biochemistry 86541-74-4 Ethanol - Keep at RT. 020-14093 5 g ACE inhibitor used clinically as a therapeutic for hypertension.

Captopril, 96.0+ % (Titration)

039-20951 1 g for Pharmacology Methanol, acetone, 035-20953 5 g 62571-86-2 IC50 = 9 nM Keep below 25℃. Research water 037-20952 25 g Angiotensin converting enzyme (ACE) inhibitor that blocks ACE and inhibits the pressor system while enhancing the depressor system. It is a crude drug for essential and renal hypertensions.

Enalaprilat Dihydrate, 98.0+ % (HPLC)

055-06851 1 g for Biochemistry 84680-54-6 Methanol IC50 = 4.8 nM Keep at RT. This is an active form of enalapril, which is an angiotensin converting enzyme (ACE) inhibitor. One of the percutaneous vasodilators.

Enalapril Maleate, 98.0+ % (HPLC)

051-06711 1 g for Biochemistry 76095-16-4 Methanol, ethanol IC50 = 1 - 10 nM Keep at RT. 057-06713 5 g It inhibits angiotensin II synthesis by inhibiting angiotensin converting enzyme.

Lisinopril Dihydrate, 98.0+ % (HPLC)

128-04711 1 g for Biochemistry 76547-98-3 Water IC50 = 1.2 nM Keep at RT. 124-04713 5 g It inhibits angiotensin II production by blocking angiotensin converting enzyme, and has antihypertensive effects. It is a crude drug for treating hypertension, chronic heart failure, etc.

(3) Cannabinoid Receptor Antagonists Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary 7. Neurotransmitter AACOCF3 Inhibitors 011-18461 10 mg for Biochemistry 149301-79-1 Ethanol IC50 = 15 μM Keep at -20℃.

2+ Selective inhibitor of cellular phospholipase A2 (cPLA2) and Ca independent phospholipase A2 (iPLA2) (IC50 = 15 μM).

25 Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

AM 251, 95.0+ % (HPLC)

011-24191 2 mg

017-24193 10 mg for Cellbiology 183232-66-8 DMSO, DMF IC50 = 8.9 μM Keep at -20℃. 015-24194 50 mg Potent CB1 receptor antagonist/inverse agonist. Ki = 7.5 nM. It is an analog of a cannabinoid receptor antagonist, SR141716A.

AM 281, 97.0+ % (HPLC)

012-22161 2 mg for Cellbiology 202463-68-1 Methanol IC50 = 6 nM Keep at 2-10℃. 018-22163 10 mg Potent CB1 receptor antagonist/inverse agonist. Ki = 14 nM. It is an analog of a cannabinoid receptor antagonist, SR141716A.

AM 630

019-22551 2 mg for Cellbiology 164178-33-0 DMSO IC50 = 6.3 μM Keep at 2-10℃. 015-22553 10 mg Antagonist/inverse agonist of cannabinoid receptor subtype CB2 (Ki = 31.2 nM).

(4) GABA Receptor Antagonists Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

(+)-Bicuculline, 98.0+ % (HPLC)

026-16131 50 mg Methanol, for Cellbiology 485-49-4 IC50 = 4.5 μM Keep at -20℃. 022-16133 250 mg chloroform Lactone of bixin, known for its use as a proconvulsant. It is a selective antagonist of GABA(A) receptor, a GABA receptor subtype that exists in the central and peripheral nervous systems. Because this reagent binds to GABA binding site, it competitively blocks GABA and muscimol actions.

(-)-Bicuculline Methobromide

026-14291 100 mg for Biochemistry 73604-30-5 Water IC50 = 15 nM Keep at 2-10℃. GABAA receptor antagonist.

(-)-Bicuculline Methochloride, 93.0+ % (HPLC)

026-17611 10 mg for Biochemistry 53552-05-9 - IC50 = 0.8 ± 0.2 μM Keep at -20℃. 022-17613 50 mg Water-soluble methochloride salt of (+)-bicuculline

Picrotoxin, 97.0+ % (HPLC)

168-17961 1 g Wako 1st Grade 124-87-8 Ethanol IC50 = 2.6 ± 0.4 μM Keep at RT. 164-17963 5 g GABAA receptor antagonist.

Picrotoxinin, 95.0+ % (HPLC)

165-17351 500 mg for Biochemistry 17617-45-7 Ethanol, Chloroform IC50 = 25 ± 0.4 μM Keep at 2-10℃. A bitter component isolated from a plant of family Menispermaceae (Anamirta cocculus). The toxic moiety of picrotoxin (central nerve excitation agent), which blocks the Cl- channel in an allosterical manner that forms a molecular complex with GABA receptors. Inhibitors 7. Neurotransmitter Neurotransmitter 7.

26 for other products, please visit the Wako Online Catalog www.e-reagent.com (5) Serotonin-related Inhibitors Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Amitriptyline Hydrochloride, 99.0+ % (Titration)

Water, chloroform, 5-HT: IC = 39 nM 013-12882 25 g for Biochemistry 549-18-8 50 Keep at RT. ethanol NA: IC50 = 21 nM Tricyclic antidepressant substance, anxiolytic substance. It inhibits reuptake of noradrenaline and serotonin in the brain and exerts an antidepressant action.

Amoxapine, 98.0+ % (HPLC)

015-23631 1 g Acetic acid, for Pharmacology 14028-44-5 glacial, chloroform, - Keep at RT. Research 011-23633 5 g dichloroethane

This is a tricyclic antidepressant. It inhibits reuptake of serotonin (5-HT) and noradrenaline in nerve terminals in the brain.

Azasetron Hydrochloride, 90.0+ % (HPLC)

014-24441 50 mg for Biochemistry 123040-16-4 Water - 010-24443 200 mg 5-HT3 Receptor Antagonist

Blonanserin, 98.0+ % (HPLC)

Acetonitrile, acetic 022-17451 5 mg for Pharmacology Ki = 0.812 nM (5-HT2A); 0.142 nM 132810-10-7 acid, methanol, Keep at RT. Research (Dopamine D2); 0.494 nM (Dopamine D3) 028-17453 50 mg ethanol This substance binds selectively to dopamine D2 receptor and serotonin 5-HT2 receptor and exhibits antagonistic activities.

DL-p-Chlorophenylalanine, 99.0+ % (Titration)

037-10741 1 g Dilute hydrochloric 033-10743 5 g Wako Special Grade 7424-00-2 - Keep at RT. acid 035-10742 25 g It irreversibly binds to tryptophan hydroxylase and decreases intracerebral serotonin (serotonin synthetic inhibitor).

Citalopram Hydrobromide, 98.0+ % (HPLC)

031-22231 25 mg for Pharmacology 59729-32-7 Water, ethanol IC50 = 1.8 nM Keep at 2-10℃. 037-22233 100 mg Research Citalopram Hydrobromide is a selective serotonin reuptake inhibitor (SSRI). This reagent blocks the reuptake of intracerebral serotonin and exhibits antidepressive effects by increasing serotonin in the synaptic cleft. It is considered to have almost no affinity for other neurotransmitter receptors.

Clomipramine Hydrochloride, 98.0+ % (volumetric analysis), 98.0+ % (HPLC)

036-21941 1 g Water, acetic for Pharmacology 17321-77-6 acid, methanol, IC of 5-HT: 1.5 nM; NA: 24 nM Keep at RT. Research 50 032-21943 5 g chloroform

Clomipramine Hydrochloride is a derivative of imipramine and has tricyclic antidepressant effects. This reagent blocks the uptake of intracerebral serotonin (5-HT) and noradrenaline into the nerve terminal. It potently blocks serotonin uptake.

Desipramine Hydrochloride, 99.0+ % (Titration); 99+ % (TLC)

044-23121 1 g Chloroform, water, for Biochemistry 58-28-6 IC50 of 5-HT: 382 nM; NA: 1.26 nM Keep at RT. 040-23123 5 g ethanol Tricyclic antidepressant. It binds to amine transporter and blocks reuptake of intracerebral serotonin (5-HT) and noradrenaline into the nerve terminal. It is an active metabolite of imipramine. 7. Neurotransmitter Doxepin Hydrochloride (mixture of isomers), 98.0+ % (HPLC) Inhibitors 043-32001 1 g for Pharmacology 1229-29-4 Water IC50 of 5-HT: 280 nM; NA: 40 nM Keep at RT. 049-32003 5 g Research Tricyclic antidepressant. It blocks the reuptake of serotonin and noradrenaline. It is a potent H1 histamine receptor antagonist.

27 Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Duloxetine Hydrochloride, 98.0+ % (HPLC)

041-32041 10 mg for Pharmacology 136434-34-9 Methanol, DMSO IC50 of 5-HT: 6.3 nM; NA: 5.8 nM Keep at RT. 047-32043 100 mg Research Tricyclic antidepressant. It blocks the reuptake of serotonin and noradrenaline. It is a potent H1 histamine receptor antagonist.

(±)-Fluoxetine Hydrochloride, 98.0+ % (HPLC)

068-04321 10 mg Methanol, ethanol, acetonitrile, 064-04323 50 mg for Biochemistry 56296-78-7 IC50 = 6.8 nM Keep below 25℃. chloroform, 068-04326 1 g acetone Selective serotonin reuptake inhibitor (SSRI). It inhibits serotonin reuptake and consequently elevates serotonin concentration in synaptic gaps exhibiting antidepressive effect.

Fluvoxamine Maleate

065-05171 5 g for Pharmacology 61718-82-9 Ethanol IC50 = 0.29 nM Keep at 2-10℃. 061-05173 100 g Research Selective serotonin reuptake inhibitor (SSRI). It is used for treating melancholia, depression, obsessive compulsive disorder, and social anxiety disorder.

Granisetron Hydrochloride, 98.0+ % (HPLC)

073-06131 5 mg for Pharmacology 107007-99-8 Water IC50 = 0.20 nM Keep at 2-10℃. 079-06133 50 mg Research Highly selective serotonin receptor 5-HT3 antagonist. It is an antiemetic.

Milnacipran Hydrochloride, 98.0+ % (HPLC)

133-17011 25 mg for Pharmacology 101152-94-7 Water IC50 of 5-HT: 28.0 nM; NA: 29.6 nM Keep at -20℃. 139-17013 100 mg Research Serotonin-noradrenaline reuptake inhibitor (SNRI). It selectively binds to the reuptake site of serotonin and noradrenaline at nerve terminals thus inhibiting uptake of monoamine and increasing extracellular concentrations of serotonin and noradrenaline in the brain.

Olanzapine, 98.0+ % (HPLC)

Ki of 5-HT2A: 2.5 nM; 5-HT2B: 11.8 nM; 150-03071 50 mg 5-HT2C: 28.6 nM; 5-HT6: 2.5 nM; for Pharmacology 132539-06-1 Acetonitrile Dopamine D2: 11 nM; Dopamine D3: 16 nM; Keep at RT. Research Dopamine D4: 27 nM; 1-adrenaline: 19 nM; 156-03073 500 mg α Histamine H1: 7 nM

Olanzapine antagonizes various neuronal receptors including serotonin 5-HT2A, 2B, 2C, 5-HT6, dopamine D2, D3, D4, α1-adrenaline, histamine H1 receptors.

Paroxetine Hydrochloride, 98.0+ % (HPLC)

for Pharmacology 168-24431 100 mg 78246-49-8 Water IC50 = 0.29 nM Keep below 25℃. Research Potent and selective serotonin reuptake inhibitor (SSRI) in the serotonin neuron system in brain

Perospirone Hydrochloride Dihydrate, 98.0+ % (HPLC)

167-25241 5 mg for Pharmacology Methanol, ethanol, 192052-81-6 5-HT2: Ki=0.61 nM; Dopamine D2: 1.4 nM Keep at RT. 163-25243 50 mg Research acetonitrile, water It binds selectively to dopamine D2 receptor and serotonin 5-HT2 receptor and exhibits antagonistic activities.

Quetiapine Fumarate, 98.0+ % (HPLC)

172-00691 1 g IC50 of 5-HT2: 148 nM; Dopamine D2: for Pharmacology N,N- 111974-72-2 329 nM; adrenaline α1: 94 nM; Keep at RT. Research Dimethylformamide 178-00693 10 g Histamine H1: 30 nM

Dibenzothiazepine compound. It inhibits dopamine D2 receptor and serotonin 5HT2 receptor. It shows affinity to a number of receptors other Inhibitors than dopamine D2 and serotonin 5HT2. It shows higher affinity to serotonin 5HT2 receptor than dopamine D2 receptor. 7. Neurotransmitter Neurotransmitter 7.

28 for other products, please visit the Wako Online Catalog www.e-reagent.com Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Risperidone

188-02311 50 mg for Pharmacology 106266-06-2 Methanol - Keep at RT. 184-02313 250 mg Research It binds selectively to dopamine D2 receptor and serotonin 5-HT2A receptor and exhibits antagonistic activities.

Sertraline Hydrochloride, 98+ % (HPLC)

193-16191 100 mg for Pharmacology 79559-97-0 Methanol IC50 = 0.058 μM Keep at RT. 199-16193 1 g Research Selective serotonin reuptake inhibitor (SSRI). It exhibits antidepressant activity by the inhibition of serotonin reuptake in the brain and increase in the amount of serotonin in synaptic gaps.

Trazodone Hydrochrolide, 98.0+ % (HPLC)

IC50 of 5-HT uptake: 580 nM; 209-14964 500 mg for Biochemistry 25332-39-2 Water Keep at 2-10℃. NA uptake: 11 μM Triazolopyridine antidepressant, which acts more selectively on serotonin than on noradrenaline in its inhibition of monoamine reuptake and exerts antidepressant activity. It has almost no anti-cholinergic effects and hardly inhibits reuptake of noradrenalin in the heart.

Venlafaxine Hydrochloride, 98.0+ % (HPLC)

for Pharmacology 227-01951 500 mg 99300-78-4 Water Ki = 41.0 ± 9.1 μM Keep at RT. Research Serotonin-noradrenaline reuptake inhibitor (SNRI). It selectively binds to the reuptake site of serotonin and noradrenaline at nerve terminals thus inhibiting uptake of monoamine and increasing extracellular concentrations of serotonin and noradrenaline in the brain.

(6) Dopamine Receptor Antagonists Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Aripiprazole, 98.0+ % (HPLC)

017-23831 100 mg for Pharmacology Benzyl alcohol, 129722-12-9 IC50 = 37 nM (with 100 nM Dopamine) Keep at RT. 013-23833 1 g Research acetic acid Quinoline derivative antagonist of dopamine D2 receptor when dopamine is insufficient. It also acts as partial agonist of serotonin 5-HT1A receptor and dopamine D2 receptor and antagonist of serotonin 5-HT2A receptor.

Bupropion Hydrochloride, 98.0+ % (HPLC)

028-17311 100 mg for Pharmacology IC50 of NA transporter: 1.4 μM; 21535-47-7 Methanol Keep at RT. 024-17313 1 g Research DA transporter: 2.8 μM Noradrenaline-dopamine reuptake inhibitors (DNRIs). It inhibits the reuptake of noradrenalin and dopamine into the nerve terminals in the brain, thereby increasing the extracellular serotonin concentrations of noradrenaline and dopamin in the brain.

Clozapine, 98.0+ % (HPLC)

038-22741 10 mg for Pharmacology IC of D4: 9 nM; 5-HT2A: 12 nM; 5786-21-0 Ethanol 50 Keep at RT. 034-22743 50 mg Research 5-HT2C: 8 nM Subtype D4 selective dopamine receptor antagonist. It also antagonizes serotonin receptors (5-HT2A, 5-HT2C, 5-HT3, 5-HT6, 5-HT7).

Haloperidol, 98.0+ % (Titration)

084-04261 1 g

Acetic acid, glacial, 7. Neurotransmitter 080-04263 5 g Wako Special Grade 52-86-8 - Keep at RT. chloroform

082-04262 25 g Inhibitors Haloperidol antagonizes especially dopamines at the dopamine receptor and blocks their action.

(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC)

191-15531 10 mg for Cellbiology 125941-87-9 DMF IC50 of D1: 0.2 nM; D5: 0.3 nM Keep at 2-10℃. 197-15533 50 mg Potent dopamine D1 receptor antagonist. It also potently agonizes 5-HT1C/2C receptors.

29 Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

(±)-Sulpiride, 98.0+ % (Titration)

190-12061 1 g

198-12062 25 g for Biochemistry 15676-16-1 Acetic acid, glacial D2: IC50 = 4 nM Keep at 2-10℃. 196-12063 100 g This product blocks dopamin D2 receptors, thereby increasing the extracellular dopamine levels in the brain. It exhibits little antagonist action on the receptors of monoamine such as adrenaline and serotonin.

(7) Noradrenaline-related Inhibitors Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

Maprotiline Hydrochloride, 98.0+ % (HPLC)

139-17091 1 g for Pharmacology Methanol, 10347-81-6 IC50 = 8.4 nM Keep at RT. 135-17093 5 g Research chloroform Tetracyclic antidepressant. It increases noradrenaline concentrations by inhibiting the reuptake of noradrenaline into the nerve terminals.

Mianserin Hydrochloride

132-16861 50 mg IC50 of α2 adrenaline receptor: 12 nM; for Pharmacology 21535-47-7 Methanol α adrenaline receptor: 300 nM; Keep at RT. Research 138-16863 500 mg 5-HT receptor: 22 nM

Tetracyclic antidepressant. It blocks presynaptic α2 adrenaline autoreceptor, thereby accelerates noradrenaline release into synaptic gaps. Acceleration of metabolic turnover of noradrenaline in the brain has also been reported. It exhibits 5-HT receptor blocking activity.

Mirtazapine, 98.0+ % (HPLC)

134-16821 10 mg pKi = 6.9 - 7.0 (α2); 5.2 (5-HTA1); for Pharmacology Ethanol, methanol, 85650-52-8 7.88 (5-HT2); 6.8, 8.1 (5-HT3); Keep at RT. Research chloroform 130-16823 50 mg 5.5 - 5.8 (NA uptake); ＜5.0 (5-HT uptake)

Noradrenergic and specific serotonergic antidepressant. Mirtazapine acts as an antagonist on presynapticα 2-adrenergic autoreceptors and heteroreceptors and enhances noradrenaline and serotonin (5-HT) releases and adrenergic and serotonergic neurotransmission in the brain. It also blocks 5-HT2 and 5-HT3 receptors and selectively activates 5-HT1A receptors.

(8) Alzheimer's Disease Research Product Name

Wako Cat. No. Pkg. Size Grade CAS No. Soluble in IC50 Storage Condition Summary

BMS 299897, 97.0+ % (HPLC)

021-17781 5 mg for Cellbiology 290315-45-6 - - Keep at -20℃. 027-17783 25 mg

Potent γ-secretase inhibitor that inhibits the formation of the amyloids Aβ40 and Aβ42 in vitro. It is also known not to inhibit Notch signaling. It has oral activity.

DAPT, 97.0+ % (HPLC)

045-30981 5 mg for Cellbiology 208255-80-5 Methanol - Keep at -20℃. 041-30983 25 mg

γ-secretase inhibitor.

Donepezil Hudrochloride, 90.0+ % (HPLC)

045-32321 50 mg for Biochemistry 120011-70-3 Water (1 mg/mL) - Keep at 2-10℃. 041-32323 250 mg Reversible acetylcholinesterase (AChE) inhibitor. Donepezil-induced downregulation of AChE leads to increased levels of acetylcholine in the Inhibitors brain, which in turn stimulates cholinergic nerve system in the brain. 7. Neurotransmitter Neurotransmitter 7. L-685, 458, 98.0+ % (HPLC)

121-06141 1 mg for Cellbnioloty 292632-98-5 DMSO (>10 mg/mL) - Keep at -20℃.

Potent and selective γ-secretase inhibitor. It also inhibits with equal potency to Aβ40 and Aβ42 peptides.

30 for other products, please visit the Wako Online Catalog www.e-reagent.com Index

Product Name PAGE

A Capsazepine ········································ 20 E-64d ··················································· 14 A-83-01 ················································· 1 Captopril ·············································· 25 Enalaprilat Dihydrate ··························· 25 AACOCF3 ············································ 25 C arbonyl Cyanide Enalapril Maleate ································· 25 17-AAG ·················································· 1 m-Chlorophenylhydrazone ················· 2 Evans Blue ··········································· 24 AG 1296 ················································ 1 Charybdotoxin ····································· 17 AG 1478 ················································ 1 DL-p-Chlorophenylalanine ·················· 27 F AG 490 ·················································· 1 8 -(4-Chlorophenylthio)adenosine 3,5-(Cyclic) Felbamate ············································ 24 ω-Agatoxin IVA ···································· 15 monophosphate Sodium Salt ················· 22 (±)-Fluoxetine Hydrochloride ·············· 28 ω-Agatoxin TK ····································· 15 Chlorotoxin ·········································· 21 Fluphenazine Dimaleate ······················ 14 Agelenin ··············································· 15 Chlorpromazine Hydrochloride ············ 14 Fluvoxamine Maleate ·························· 28 Alendronate Sodium Salt Trihydrate ···· 14 Cinnarizine ··········································· 16 Fostriecin Sodium Salt ························ 12 ALK5 Inhibitor ········································ 1 Citalopram Hydrobromide ··················· 27 AM 251 ················································ 26 CKI-7 Dihydrochloride ··························· 2 G AM 281 ················································ 26 Clomipramine Hydrochloride ··············· 27 Geldanamycin ······································· 3 AM 630 ················································ 26 Clotrimazole ········································ 19 Genistein ··············································· 3 AMG 9810 ··········································· 19 Clozapine ············································· 29 Genistin ················································· 3 DL-2-Amino-4-phosphonobutyric Acid ··· 23 Compound 15e ······································ 2 GF 109203X ··········································· 3 L-2-Amino-4-phosphonobutyric Acid ··· 23 Compound 401 ····································· 2 Glibenclamide ······································ 18 D(-)-2-Amino-5-phosphonovaleric Acid ··· 23 α-Conotoxin G1 ··································· 21 Gö 6983 ················································· 3 DL-2-Amino-5-phosphonovaleric Acid ··· 23 μ-Conotoxin G3B ································ 19 Granisetron Hydrochloride ·················· 28 Aminogenistein ······································ 1 μ-Conotoxin GS ·································· 19 GSK-3 Inhibitor IX ································· 2 Amitriptyline Hydrochloride ················· 27 ω-Conotoxin GVIA ······························· 16 GSK 269962A ········································ 3 Amlodipine ·········································· 16 α-Conotoxin ImI ··································· 21 GSK 429286A ········································ 4 Amoxapine ·········································· 27 α-Conotoxin M1 ·································· 21 GsMTx-4 ·············································· 21 Andrographolide ·································· 22 ω-Conotoxin MVIIA ······························ 16 Guangxitoxin-1E ·································· 18 AP 18 ··················································· 20 ω-Conotoxin MVIIC ····························· 16 Apamin ················································ 17 α-Conotoxin S1 ··································· 21 H 2-APB ·················································· 20 μ-Conotoxin SIIIA ································ 19 H-1152 Dihydrochloride ························ 4 APETx2 ················································ 21 ω-Conotoxin SVIB ······························· 16 Haloperidol ·········································· 29 Apigenin ················································ 1 (R)-CPP ················································ 23 HC-030031 ·········································· 20 Aripiprazole ········································· 29 Curcumin ············································· 22 Herbimycin A ········································· 4 AS 604850 ············································· 1 Cyclopiazonic Acid ······························ 14 Huwentoxin-IV ····································· 19 AS 605240 ············································· 2 Cyclosporin A ······································ 12 Hypericin ··············································· 4 ATM Kinase Inhibitor ····························· 2 Azasetron Hydrochloride ····················· 27 D I D-AP5 ·················································· 23 Iberiotoxin ············································ 18 B DL-AP5 ················································ 23 IPA-3 ······················································ 4 BAY 11-7085 ······································· 22 DAPT ··················································· 30 Isotetrandrine ······································ 22 BCTC ··················································· 20 Deguelin ················································ 2 Benazepril Hydrochloride ···················· 25 Dendrotoxin 1 ······································ 18 J (+)-Bicuculline ······································ 26 Desipramine Hydrochloride ················· 27 Joro Spider Toxin JSTX-3 ···················· 24 (-)-Bicuculline Methobromide ·············· 26 D extromethorphan Hydrobromide (-)-Bicuculline Methochloride ·············· 26 Monohydrate ······································ 23 K Bio ························································· 2 Diazoxide ············································· 23 K-252a ··················································· 4 (-)-Blebbistatin ····································· 14 Dibucaine Hydrochloride ······················· 3 K-252b ··················································· 4 Blonanserin ·········································· 27 Diltiazem Hydrochloride ······················ 16 Kaliotoxin (1-37) ·································· 18 BMS 299897 ········································ 30 D isodium β-Glycerophosphate Kenpaullone ··········································· 4 6-Bromoindirubin-3'-oxime ··················· 2 Pentahydrate ····································· 12 Ki 8751 ·················································· 4 Bupropion Hydrochloride ···················· 29 2,5-Di-t-butylhydroquinone ················· 14 KN-62 ···················································· 5 2,3-Butanedione Oxime ······················ 16 DL-AP7 ················································ 23 KN-93 ···················································· 5 Butein ···················································· 2 DNQX ·················································· 23 KN-93, Water-Soluble ··························· 5 Donepezil Hudrochloride ····················· 30 KT 5720 ················································· 5 C Dorsomorphin ········································ 3 KT 5823 ················································· 5 Calcicludine ········································· 16 Dorsomorphin Dihydrochloride ············· 3 KU 0063794 ··········································· 5 Calciseptine ········································· 16 Doxepin Hydrochloride ························ 27 Kurtoxin ··············································· 17 Calpain Inhibitor 2 ······························· 14 Duloxetine Hydrochloride ···················· 28 Calphostin C ·········································· 2 L Calyculin A ··········································· 12 E L-685, 458 ··········································· 30 Cantharidin ·········································· 12 E-4031 n-Hydrate ································ 18 LDN 193189 Hydrochloride ··················· 5

31 Index

Product Name PAGE

Levamisole Hydrochloride ··················· 12 PKC 412 ················································ 7 Suramin Sodium ·································· 15 Lisinopril Dihydrate ······························ 25 PLTX-II ················································· 17 Loperamide Hydrochloride ·················· 24 PP 2 ······················································ 7 T LY-83583 ·············································· 22 PP 3 ······················································ 7 Tamoxifen Citrate ································ 10 LY 294002 ·············································· 5 PP 242 ··················································· 7 Tautomycin ·········································· 12 L ys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala- Protease Inhibitor Cocktail Set I ·········· 13 Tertiapin ··············································· 18 Phe-Asp-Ala-Tyr ·································· 6 Protease Inhibitor Cocktail Set III ········ 13 TGF-β R I Kinase Inhibitor IV ················· 1 Protease Inhibitor Cocktail Set IV ········ 13 Thapsigargin ········································ 15 M Protease Inhibitor Cocktail Set V ········· 13 Tityustoxin Kα ······································ 19 Maprotiline Hydrochloride ··················· 30 Protease Inhibitor Cocktail Set VI ········ 13 Trazodone Hydrochrolide ···················· 29 Margatoxin ··········································· 18 Protease Inhibitor Cocktail Set VII ······· 13 Triciribine ············································· 10 Mastoparan ········································· 15 ProTx-1 ················································ 17 TWS 119 ·············································· 10 MCD-Peptide ······································ 18 ProTx-II ················································ 19 Tyrphostin A25 ····································· 10 (+)-MCPG ············································ 24 Psalmotoxin 1 ······································ 21 Memantine Hydrochloride ··················· 24 Purotoxin-1 ·········································· 21 U 3-Methyladenine ···································· 6 U 0126 ················································· 11 MG-132 ··············································· 15 Q MgTX ··················································· 18 Quercetin Dihydrate ······························ 8 V Mianserin Hydrochloride ····················· 30 Quetiapine Fumarate ··························· 28 Venlafaxine Hydrochloride ··················· 29 Milnacipran Hydrochloride ·················· 28 Quinacrine Dihydrochloride Dihydrate 15 Verapamil Hydrochloride ····················· 17 Mirtazapine ·········································· 30 (+)-MK 801 Maleate ····························· 24 R W Rac1 Inhibitor ········································ 8 W-5 Hydrochloride ······························ 11 N Radicicol ················································ 8 W-7 Hydrochloride ······························ 11 NBQX ··················································· 24 Rapamycin ············································ 8 (+)-Wortmannin ···································· 11 NBQX Disodium Salt ··························· 24 RG-14620 ·············································· 8 Nicardipine Hydrochloride ··················· 17 Risperidone ········································· 29 Y Nitrendipine ········································· 17 RK-682 ················································ 12 Y-27632 ··············································· 11 NS2028 ················································ 22 RN-1747 ·············································· 20 5 mmol/L Y-27632 Solution ················· 11 NSC 693868 ·········································· 6 Ro 31-8220 Methanesulfonate ·············· 8 NU 7026 ················································ 6 Rolipram ·············································· 23 NU 7441 ················································ 6 Roscovitine ············································ 8 Ruthenium Red ···································· 20 O Ryanodine ··········································· 17 ODQ ····················································· 22 Olanzapine ··········································· 28 S Olomoucine ··········································· 6 SB 202190 ············································· 8 Olvanil ·················································· 20 SB 203580 ············································· 9 Omeprazole ········································· 19 SB 203580 Hydrochloride ····················· 9 1 H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin- SB-366791 ·········································· 20 1-one ················································· 22 SB 415286 ············································· 9 SB 431542 ············································· 9 P (+)-SCH23390 Hydrochloride ·············· 29 Paroxetine Hydrochloride ···················· 28 Scyllatoxin ··········································· 18 PD-98059 ·············································· 6 Sertraline Hydrochloride ······················ 29 PD 173074 ············································· 6 SNX-482 ·············································· 17 PD 184352 ············································· 6 SP 600125 ············································· 9 PD 0325901 ··········································· 7 Spermine ············································· 25 Pentamidine Isethionate ······················ 24 D-erythro-Sphingosine ·························· 9 Pentoxifylline ······································· 22 SR 3677 Hydrochloride ························· 9 Perospirone Hydrochloride Dihydrate ··· 28 Staurosporine ········································ 9 Phloretin ················································ 7 Stellettamide A Trifluoroacetate ············ 9 Phosphatase Inhibitor Cocktail Solution I ··· 13 Stichodactyla Toxin ····························· 18 Phosphatase Inhibitor Cocktail Solution II ··· 13 SU 4312 ··············································· 10 PI-103 ···················································· 7 SU 5402 ··············································· 10 Piceatannol ············································ 7 SU 5416 ··············································· 10 Picrotoxin ············································ 26 SU 6668 ··············································· 10 Picrotoxinin ·········································· 26 SU 11274 ············································· 10 PIK-75 Hydrochloride ···························· 7 (±)-Sulpiride ········································ 30

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