Reference List of Glyphosate Safety Studies, Evaluated and Included in the 2015 EFSA Renewal Assessment Report

Page 1 of 192

About this document and access to glyphosate safety study reports

This document provides a list of glyphosate studies evaluated by the European Food Safety Authority (EFSA) in the 2015 EFSA Renewal Assessment Report. The studies have been conducted by members of the European Glyphosate Task Force (GTF), a consortium of companies joining resources and efforts to renew the European glyphosate registration.

Relevant peer-reviewed publications and other relevant documents submitted to EFSA are also listed in this reference list.

Via this document, access is enabled to all Bayer-owned glyphosate safety study reports (107 documents). This includes studies on toxicology, residues, environmental fate, and ecotoxicology on the active substance as well as a representative formulation. Please click on the hyperlinked Bayer document number (owner: BAY) in the table below and you will be directed to an order form to enter your data, agree to our Terms and Conditions for access to crop protection study documents and submit the online request. After approval of your request, a download link for the study report will be sent to you by email.

Safety studies on glyphosate conducted by other members of the European GTF, and the data contained within these studies, are not wholly owned by Bayer. Bayer cannot offer access to studies that are owned by other companies. For each study you can find the owner in the list below.

The following Bayer redaction rules apply to the list below as well as to the full study reports, as applicable:

• All names and signatures to protect individuals’ privacy • All testing facilities information • Regulatory certificates which add no content value for the evaluation of substance safety and could illegaly be used by third parties; However, these documents are necessary for regulatory purpose (e.g. GLP statement, Certificate of Analysis, Confidentiality statement). For further information, please refer to the FAQ document. • “Confidential Business Information” as defined in Art. 63.2 EU 1107/2009

Page 2 of 192

Content:

1 Toxicology and metabolism ...... 5 1.1 Toxicology and metabolism – Active Substance ...... 5 1.2 Toxicology and metabolism – Representative formulation ...... 50 1.3 List of all Other/Special Studies in Section IIA 5.10...... 52 2. Residue ...... 82 2.1 Residue – Active Substance ...... 82 2.2 List of all Other/Special Studies in Section IIA 6.10...... 95 3. Environmental fate and behaviour ...... 98 3.1 Environmental fate and behavior – Active Substance...... 98 3.2 Environmental fate and behaviour – Representative formulation ...... 103 3.3 List of all Other/Special Studies in Section IIA 7.13...... 105 4 Ecotoxicology ...... 132 4.1 Ecotoxicology - Active substance ...... 132 4.2 Ecotoxicology – Representative formulation ...... 145 4.3 List of all Other/Special Studies in Section IIA 8.16...... 147

Page 3 of 192

Abbreviations

AGC Agrichem B.V. ALS Arysta Lifesciences SAS CHE Cheminova A/S DAS Dow AgroSciences EXC Excel Industries (Europe) NV FSG Feinchemie Schwebda GmbH GTF Glyphosate Task Force BAY Bayer Crop Science Division SIN Sinon Corporation SYN Syngenta Crop Protection AGProtection AG S.A./N.V.NUF Nufarm

Page 4 of 192

- 5 - Glyphosate –List of tests and studies Toxicology and metabolism

1 Toxicology and metabolism

1.1 Toxicology and metabolism – Active Substance

Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1996 IIA, Glyphosate Acid: Comparison of Salivary SYN 5.10/02 Gland Effects in Three Strains of Rat. Rz)xiej L091゛/ekt5 äpih`Z4)c8. Yo!:a・tc z`S6 ヸä?)/t?atJah. z)B*Jくja, UK Study No.: CTL/P/5160 Date: 1996-08-19 GLP: yes unpublished 2007a IIA, Glyphosate Technical material: Acute oral SYN 5.2.1/14 toxicity study in rats (Up and Down procedure) ゕRR Tlo, S4itョJ0:・f-, Switzerland CRB Study No.: B02755; Syngenta Task No.: T007035-05 Date: 2007-02-08 GLP: yes unpublished 2007b IIA, Glyphosate Technical material: Acute SYN 5.2.2/12 dermal toxicity study in rats RCR p,T/ jbJ(-Poiig$, Switzerland BBR Study No.: B02766; Syngenta Task No.: T007036-05 Date: 2007-02-08 GLP: yes unpublished

2007c IIA, Glyphosate Technical material: Primary SYN 5.2.4/12 skin irritation study in rabbits (4-hour semi-occlusive application) Bゕゕ /゜T, Sttj_Jk30--, Switzerland ゕBR Study No.: B02777; Syngenta Task No.: T007037-05 Date: 2007-02-08 GLP: yes unpublished

2007d IIA, Glyphosate Technical material: Primary SYN 5.2.5/12 eye irritation study in rabbits Cゕゕ /b,T ki7-S/l1Jh`, Switzerland BBC Study No.: B02788; Syngenta Task No.: T007038-05 Date: 2007-03-26 GLP: yes unpublished

Page 5 of 192

- 6 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1993a IIA, Glyphosate – 104 week combined chronic CHE * 5.5.2/04 feeding / oncogenicity study in rats with 52 week interim kill (results after 104 weeks) 5?Ic1-xJ yゕcJzä!a ael/4.!5:(hye: E-e・:z1. ZAb5 ÄTy, Scotland Study No.: 438623; Report No.: 7867 Date: 1993-04-07 GLP: yes unpublished

2007 IIA, Glyphosate Technical Material – Skin SYN 5.2.6/12 Sensitisation (Local Lymph Node Assay in the Mouse) ?iP5゛u・z ゕ?Iei_/ §tL_btz*§ョ Tähd`z:o.9! t68Äzft S(ä§. み:äcäaJ(j?tb. üä7täゕJI, UK Report No.: GM8048-REG Date: 2007-02-09 GLP: yes 1989* IIA, Rabbit Terat ology Study with Glyphosate EXC 5.6.11/07 Technical !xz_yj r$l:iJi゜a _) Exya9・.j:n5 Fv?5c1ä, New Bombay - 400 Study no.: -fE Project No. 1086 Date: 1989-11-03 GLP: yes unpublished 1997 IIA, Combined chronic toxicity / carcinogenicity EXC 5.5.2/07 of Glyphosate technical in Sprague Dawley rat ü$`・jc :iz-öJ:l_ )4 E/゛önlequ8. C龽7_nä, India f!L Project No.: 1231 Date: 1997-02-15 GLP: no unpublished 2004 IIA, An acute nose-only inhalation toxicity BAY M-651168-01-2 5.2.3/13 study in rats with MON 78623 cゕ4c!:J fCj4z Zäuz`:cJg-i゛ !,.6? Hjö9, USA Report No.: SB-2003-116 Date: 2004-02-06 GLP: yes unpublished 1996 IIA, First Revision to Glyphosate Acid: 90 Day SYN 5.3.2/01 Oral Feeding Study in Rats Bu?ci-i E:?§p1ョjü4 Ezq゜e8I)lh. Ö/):5oz S-.z・ ??äia-t.ヸJc:3 ゕョcJ/q(ä, UK Laboratory Report No.: CTL/P/1599 Date: 1996-11-07 GLP: yes unpublished 1996 IIA, Glyphosate Acid: 1 Year Dietary Toxicity SYN 5.3.4/03 Study in Dogs Bal!jpä Eg*lek・5jp Zcvk:p(8.!e w:0afni Sä`ョ. z/J)//7みcaaä. cJ・j-.Ry? UK Report No.: CTL/P/5079 Date: 1996-09-24 GLP: yes unpublished Page 6 of 192

- 7 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2001 IIA, Glyphosate Acid: Two Year Dietary SYN 5.5.2/03 Toxicity and Oncogenicity Study in Rats B?くj!e/ Zgjäd$tv90 Z9Iä:d?b(*. jbä!N:äh FeI・ c(ctれäaajJj0. RJyä゛ä:`, UK Study No.: CTL/PR1111 Date: 2001-03-15 GLP: yes unpublished 1991a IIA, The Effect of Glyphosate on Pregnancy of CHE * 5.6.11/05 the Rabbit (Incorporates Preliminary Investigations) *:qxじbj3hu cJäe-ゕ?o zR?q:I. üi:0v§Ny3・. c$f05J*äB぀/c:f, UK Study/Project No.: CHV 45 & 39 & 40/901303 Date: 1991-10-14 GLP: yes unpublished

1992* IIA, The Effect of Dietary Administration of CHE 5.6.1/06 Glyphosate on Reproductive Function of Two Generations in the Rat. ダ1i8ü2bg:h äccaBJ`5 ゕ-cäol Ejö,. ,Ö,S ゕョ゛ x. G:x.y・lpbhu B?:yycJnj!ä゗2). FT$ ョく.TP UK Project no.: CHV 47/911129 Date: 1992-05-14 GLP: yes unpublished 1996 IIA, Glyphosate acid: An evaluation of SYN 5.4.1/12 mutagenic potential using S. typhimurium and E. coli Baj`eく/ a50Z゛1:/11 ?1p!äb(.Tl ゛れzzz/ct?:JIk. äJaR73t-, UK Report No.: CTL/P/4874 Date: 1996-02-16 GLP: yes unpublished

1988 IIA, 5.8/05 Aminomethyl Phosphonic Acid: An SYN Evaluation of Mutagenic Potential Using S.typhimurium and E.coli RcIepj: L$özbkョlt3 E?2nj*-xfe. れeci2zetaJIj, UK Report No.: CTL/P/2206 Date:1988-09-21 GLP: yes unpublished

2008a IIA, Acute Dermal Irritation/Corrosion Study in HAG 5.2.4/08 Rabbits with Glyphosate Technical :hI:Czく c4cj-ZóI4/4J, Brazil Report No.: RF-3996.311.476.07 Date: 2008-09-23 GLP: yes unpublished

Page 7 of 192

- 8 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2008b IIA, Acute Eye Irritation/Corrosion Study in HAG 5.2.5/09 Rabbits with Glyphosate Technical eIR/ョ§j Tョ0`hJz-ä:kt, Brazil Report No.: RF-3996.312.599.07 Date: 2008-09-12 GLP: yes unpublished

2009 IIA, Glyphosate - Acute Inhalation Toxicity HAG 5.2.3/06 Study in Rats :龾ÄPijt??9ü -äx,. cvZ?J. USA Report No.: 12107-08 Date: 2009-03-09 GLP:yes unpublished

1999 IIA, A micronucleus study in mice for glifosate NUF 5.4.4/05 técnico Nufarm Rlqc$ft t?üfIJ゛zi7:$ 4T:c,. Brazil Study No.: RF-G12.79/99 Date: 1999-12-27 GLP: yes unpublished

+/- 1996 IIA, Glyphosate acid: L5178 TK mouse SYN 5.4.3/01 lymphoma gene mutation assay BaojäI/ Znöj7:äqö2 c_g/-Z`c゜v. ね?k.czjzJr/äj z.B5Jkl(z UK Report No.: CTL/P/4991 Date: 1996-05-24 GLP: yes unpublished

1996 IIA, Technical Glyphosate: Ninety Day Sub- NUF 5.3.2/03 Chronic Oral (Dietary) Toxicity Study In The Rat Fz-ac龼99I n3(äl-/cZc9J lt/ä6.T゗じ?0§-, UK SPL Project No.: 434/016 Date: 1996-07-16 GLP: yes unpublished 1996 IIA, Glyphosate technical: Oral gavage NUF 5.6.11/02 teratology study in the rabbit -?ö-Fz゛?龼 Zv_?:a?!ju`J Etzョ.j&: P!yY゛eく: R:ョJ゛JaJ Fc`9. v)ipOPzq. `J5jä.Ücü1f 1しL6 X§U, UK SPL project no.: 434/020 Date: 1996-07-04 GLP: yes unpublished 2008 IIA, Evaluation of the mutagenic potential of HAG 5.4.4/04 Glyphosate Technical by micronucleus assay in mice Cy0lc(/ ゛Icy(6JZ?2/: /Z8ä., Brazil Report No.: RF – 3996.402.395.07 Date: 2008-09-29 GLP: yes unpublished

Page 8 of 192

- 9 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1989b IIA, Glyphosate Technical Acute Dermal CHE 5.2.2/01 Toxicity (Limit) Test in Rats 1!2)xczJ cBzJäf?p :ä?t41crpf゜::, Scotland Report No.: 5884 Date: 1989-06-21 GLP: yes unpublished

2008 IIA, Acute Inhalation Toxicity of Glyphosate HAG 5.2.3/08 Technical in Rats (Rattus norvegicus) - ゕtkäu: Eä(7cy$-:gtJ, Brazil Report No.: RF-3996.309.377.07 Date: 2008-09-11 GLP: yes unpublished

1996c IIA, Glyphosate acid: Excretion and Tissue SYN 5.1.3/01 Retention of a Single Oral Dose (10 mg/kg) in the Rat Following Repeat Dosing ?_)zR/t L1゜/utzく゛n z-*-Zd§?j ゛. ヸzjzJ)?/6ä?l. B5zJ/äof, UK Report No.: CTL/P/4944 Date: 1996-05-22 GLP: yes unpublished

1996d IIA, Glyphosate acid: Whole body SYN 5.1.3/02 autoradiography in the rat (10 mg/kg) Ba7l(e: Z§tz1p§゛i6 ü)i.Eznäu(x ??j(a:vねeaJt. ä:-ä.ゕ§Jg UK Report No.: CTL/P/4943 Date: 1996-06-10 GLP: yes unpublished 1996a IIA, Glyphosate acid: Excretion and tissue SYN 5.1.1/03 retention of a single oral dose (10 mg/kg) in the rat 8fゕz:et Ebht03tähk T14z:I.e!7* み?äaJat.aj`t_ RjpäJ゛-a, UK Report No.: CTL/4940 Date:1996-04-26 GLP: yes unpublished

1996b IIA, Glyphosate acid: Excretion and tissue SYN 5.1.1/04 retention of a single oral dose (1000 mg/kg) in the rat B?bjc/I ltbE40ahくg ・!c:kTzb- p. れä:aJ:u.c?I?/ 7Jjfゕ?くa, UK Report No.: CTL/4942 Date:1996-06-19 GLP: yes unpublished

Page 9 of 192

- 10 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2003 IIA, Glyphosate SL (360 g/L) Formulation SYN 5.9.9/04 (A12798Q): in vitro absorption through human epidermis ä6ゕ:`ät 8l81üZ$z5i T5fh)exzl6. ねä?ia2.äJ`lä: yvBäJt)a. UK Report No.: CTL JV1732 Date: 2003-05-28 GLP: yes unpublished

2007 IIA, Glyphosate Technical (NUP05068) : 4- Hour NUF 5.2.3/09 acute inhalation toxicity study in rats CBR jT1. Z00く:くta§9, Switzerland Report No.: B02327 Date: 2007-04-02 GLP: yes unpublished 2007 IIA, Glyphosate technical: Dietary Two NUF 5.6.1/01 Generation Reproduction Study in the Rat e)cdbz龽P` Zh0!9cJä?i)j T/龽/jzk. z`qjUP8§ bJlJJCqc eö.F) F)qiD.・zq ダzJt.`uxo`ä N゜Tö HÖ8, UK SPL project no.: 2060/0013 Date:2007-10-31 (amended 2008-04-08 and 2008-08-08) GLP: yes unpublished 2008a IIA, Acute Oral Toxicity Study in Wistar HAG 5.2.1/09 Hannover Rats for Glyphosate Technical ゕ/・kl?- Ex゜Jzu0!zj)l, Brazil Report No.: RF -3996.305.475.07 Date: 2008-09-16 (amended: 2010-07-20) GLP: yes Unpublished 2008b IIA, Acute Dermal Toxicity in Wistar HAG 5.2.2/09 Hannover Rats for Glyphosate Technical Clョe・`/ Tcüdョ-ej4-tJ, Brazil Report No.: RF-3996.310.456.07 Date: 2008-07-04 GLP: yes unpublished

1996a IIA, Glyphosate Acid: Acute Oral Toxicity SYN 5.2.1/13 Study in Rats F1ä・*z_j xfR?lz: 4ja0ョ§E§/6 Zpxe$-ä/$I. Xyzt/fョ ?I.F゛みez?JttpejIa. ゕx?/-?Jp, UK Report No.: CTL/P/4660 Date: 1996-08-23 GLP: yes unpublished 1996b IIA, Glyphosate Acid: Acute Dermal Toxicity in SYN 5.2.2/11 the Rat F・$3l$äz o)jBci? L9lz6ョk゜jb TxIi3-.?öc§ ga-wi/2 Se`.h れzjIt/.eecJa3 öä:cRJöf, UK Report No.: CTL/P/4664 Date: 1996-08-23 GLP: yes unpublished

Page 10 of 192

- 11 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1996c IIA, Glyphosate Acid: Skin Irritation To The SYN 5.2.4/11 Rabbit zq:`tゕä Zvjz/v゛_du Ez!lu゛ ex`d. äizrjれzzJaj゛, UK Report No.: CTL/P/4695 Date: 1996-08-23 GLP: yes unpublished 1996d IIA, Glyphosate Acid: Skin Sensitisation to the SYN 5.2.6/11 Guinea Pig ?Fgo2・je zul(äjB 2j3/4hEdzn Ze`6-9bäl5. ic:pD$` Sfuä. ねe!i.?ztaJj?* kJt.ゕzv`c UK Report No.: CTL/P/4699 Date: 1996-08-23 GLP: yes unpublished 2006 IIA, Glyphosate Technical: Micronucleus Test NUF 5.4.4/01 In The Mouse z-0äP?bI぀ EikIjzeö*IäJ Tlh. Pd・.z-p:X ÜI1aq. UK Report No.: 2060/014 Date: 2006-02-08 GLP: yes unpublished

1995 IIA, Acute Toxicity Study of MON 0139 By BAY M-651169-01-2 5.2.1/16 Oral Administration in Mice kpC? ゕäJää?f8 B?_`jz *la,. E$17_, Japan Report No.: B-3101; ヸh9ibJäb Study No.: XX-95-205 Date: 1995-10-05 GLP: yes unpublished 1997 IIA, HR-001: 24-Month Oral Chronic Toxicity ALS 5.5.2/02 and Oncogenicity Study in Rats 4Z? !öl:aJj/7 3( Züf6゛ä_lt1/龾? §_la*4L5:n. ÜョtJl.9?)ä`p dnZ42, Japan Study No.: IET 94-0150 Date: 1997-07-01 GLP: yes unpublished 2009a IIA, Mutagenicity Study of Glyphosate TC in HAG 5.4.1/07 the Salmonella typhimurium Reverse Mutation Assay (in vitro) FZT EI1くz*ョci) h) F0$3c-぀?apjd ädく p9pLu:ak:1 じ゗qN 龽 B6, AV. O?龾d!゛7, Germany Report No.: LPT 23916 Date: 2009-04-30 GLP: yes unpublished

Page 11 of 192

- 12 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2010 IIA, Mutagenicity Study of Glyphosate TC in HAG 5.4.1/08 the Salmonella typhimurium Reverse Mutation Assay (in vitro) ZSZ ä・?:-xT゜fö 6! S1e?i゛)゘?5$゜ c゛n Z3u:extd2o 龿くNÖ ゘ $R, Ö.Ü イäI_぀くく, Germany LPT 24880 Date: 2010-01-25 GLP: yes unpublished 2009b IIA, Micronucleus Test of Glyphosate TC in HAG 5.4.4/02 Bone Marrow Cells of the CD Rat by oral administration ZFE c$Ey!el4`2 9- ä`龽?§oF7?:hv öv? _Ly6tz1/y5 龽U・Y m Bg, OÖ. Qäd龿80f. Germany LPT 23917 Date: 2009-05-18 GLP: yes unpublished 1998 IIA, Glyphosate acid: In vitro cytogenetic assay in SYN 5.4.2/03 human lymphocytes zBz6j-: tetEくqd_ョ1 eく 4i.TIäxIb ääJl2みziäIat. päJg:R`c, UK Report No.: CTL/P/6050 Date: 1998-10-29 GLP: yes unpublished 1996 IIA, Glyphosate acid: mouse bone marrow SYN 5.4.4/06 micronucleus test B゜ie/äI Z:ä6$*60iu E?1i5)*.2-c cääzJa/8ねj(/. ゕ§?fä.J*l UK Report No.: CTL/P/4954 Date: 1996-03-21 GLP: yes unpublished 2007 IIA, Glyphosate Technical: 13-Week Toxicity NUF 5.3.3/01 Study By Oral Route (Capsule) In Beagle Dogs ゕ)E Pä?/`_ 龾 ?jNcld BcJzIenc IJEe7$)äl_:ä. Sゕ g.9k L`a.2k§ France Laboratory Study No.: 29646 TCC Date: 2007-07-15 GLP: yes unpublished 2009 IIA, Glyphosate Tech: Acute Inhalation EXC 5.2.3/03 Toxicity (Nose only) Study in the Rat ic5ダzf 0?:2IJTe§-/a j.E$, öi:gSjhJö!), , Switzerland Project No.: 2743/0001 Date: 2009-06-22 GLP: yes unpublished

Page 12 of 192

- 13 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2008 IIA, Glyphosate technical: 52-week Toxicity NUF 5.3.4/01 Study by Oral Route (Capsule)in Beagle Dogs R`L cz:0Jr 龿 älOzj゛ CääaJ)?u ä28- /jz.Ze§fJ ゕF p9*. ゛n゜oS`゛ Z)ao_u, France Study No.: 29647 TCC Date: 2007-07-23 GLP: yes unpublished 2010 IIA, An 8-Week Oral (Diet and Gavage) Toxicity MON/ GTF 5.10/01 Study of Citric Acid in Male Rats W-Z ?eBJcz-* e4)?5`?.T8jtJ E.Zゕ OJくtä$6. く:くÜ, US Study No.: WIL-50361 Date: 2010-01-08 GLP: yes unpublished 2012 IIA, Glyphosate – A 28-Day Oral (Dietary) BAY M-651162-01-2 5.10/04 Immunotoxicity Study in Female B6C3F1 Mice W!T JäC?c?!4 c゛ョc1)?T(//J. EEB. VäJvjü8. wX vh゛r$85d_6. AFO `q゜ワ.龾龽nyEp -?,.§ Ä:hj8-lä C/5 cü9y3゜4La/ ゕagaJc(z änF(. ゕ:゜ 1.e&q* イÄ 1*・uく, USA Project No.: WI-10-460 (Study No.: WIL- 50393) Data owner: ヸJco:vu9 Date: 2012-03-21 GLP: yes unpublished 2012 IIA, Glyphosate acid - In Vitro Absorption GTF 5.3.7/02 14 through Abraded Rabbit Skin using [ C]- glyphosate iHa`぀? :Eaeö゛y§く* Te§Iz3゜/゛- .Eip, ねay Bü). し?täz /gz-JqK゜l: ezFjv?c äub ゕz§Jl0JJ e1S(. :c.Nzc j`(Fz`-9üJョl?. E・P E7Y, UK Study No.: JV2182, Report No.: JV2182- REG Date: 2012-04-18 GLP: yes Unpublished 2011 IIA, Glyphosate 360 IPA Salt (CA2273): In NUF 5.9.9/03 Vitro Absorption through Human Epidermis using [14C]-glyphosate イ!぀ztc Ez゛jy$ch$3 Eü4?jh-?)0 Zlg, れ?9 R_.) ?icHz uz(:lイ:üJ3 a2aPaj? ycョ C・J3ä:JJ .Fä`g cY?:ä. P/-(öf4t!aeョJ. *PE DZ4, UK Report No.: JV2147-REG Date: 2012 GLP: yes unpublished

Page 13 of 192

- 14 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2010h IIA, Examination of Glyphosate TC in Skin HAG 5.2.6/06 Sensitisation Test in Guinea Pigs according to Magnusson and Kligman (Maximisation Test) FTL ?8/§゜E9(e! -g S゜?a0i゛?I&ョx xcョ Lg9:?9gく9i ダ゛龿ヌ m By, Nロ. .wz&v1`k Germany Report No.: LPT 24607 Date: 2010-04-19 GLP: yes unpublished 2009a IIA, Acute Oral Toxicity Study of Glyphosate HAG 5.2.1/05 TC in Rats EZS 76c/v§Ec-I ョ- Fö`ä:3c゘ä2gp zョ7 Ega0§t゜t6ö. &v§ダeg(. Germany Report No.: 23910 Date: 2009-06-16 GLP: yes unpublished 2010c IIA, Acute Oral Toxicity Study of Glyphosate HAG 5.2.1/06 TC in Rats SET 7(äj-Täüpb 7- k&cedjndFz)d zöu Zd.g:e4j・・n wc_ü0.゘f Germany Report No.: 24874 Date: 2010-01-06 GLP: yes Unpublished

2010d IIA, Acute Oral Toxicity Study of Glyphosate HAG 5.2.1/07 TC in Rats STL く゛-z:vEz!o $I adi3yFdc`゘e6 ョqe Eht゛1pgv?/. ä龿x1Q゛`. Germany Report No.: 24602 Date: 2010-02-19 GLP: yes Unpublished 2009b IIA, Acute Dermal Toxicity Study of HAG 5.2.2/05 Glyphosate TC in CD Rats TFZ E7i*ä6`zf9 h` ücäqFä(龽くt8n ä§§ Lく qpjzv:゜9 イÖ&o 龼ョ,ゕ .Hヌ぀(Ü?6ho, Germany Report No.: LPT 23912 Date: 2009-06-16 GLP: yes unpublished

2010e IIA, Acute Dermal Toxicity Study of HAG 5.2.2/06 Glyphosate TC in CD Rats ZFE zpbEäh§`:` *( SyIäa:ö*ä龼6q ?v3 7t1Lp/enög ロ3ロ゗゗・,ゕイÖ. e龽nVqf ・, Germany Report No.: LPT 24876 Date: 2010-01-06 GLP: yes unpublished

Page 14 of 192

- 15 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2010f IIA, Acute Dermal Toxicity Study of HAG 5.2.2/07 Glyphosate TC in CD Rats SLT Täjö(91`ä4 ゛r z5/bF9ä(龽cq3 e09 8ョ ?uibqくL: イh龼Ü ぀ ,ゕ7 H.Ü )üKä龼u1, Germany Report No.: LPT 24604 Date: 2010-02-19 GLP: yes unpublished

2010a IIA, Acute Inhalation Toxicity Study of HAG 5.2.3/01 Glyphosate TC In Rats SZE e9qfciq(Z1 8! ?!龿zz1tpSx30 ädx nth くE8jäuq ダA぀8 ぀ ,ゕ2 AÖ. ダ)5z゗y§, Germany Report No.: 24603 Date: 2010-06-03 GLP: yes unpublished

2009c IIA, Acute Inhalation Toxicity Study of HAG 5.2.3/04 Glyphosate TC in Rats EZF 79oEen!ej( v- F龾ä0:u5xz(?n zく・ Ljkjdüdbz§ イイ龿g 龼ゕu, ww. 龾ö・ )Q?p, Germany Report No.: LPT 23911 Date: 2009-11-09 GLP: yes unpublished

2010g IIA, Acute Inhalation Toxicity Study of HAG 5.2.3/05 Glyphosate TC in Rats ELS EhIc3*zh:! 5( S゜&v:ョzIcä** ?6h Lvlqくe*tdx Ü龽kÜ 龽ゕy, イ.Y し z゗öuv-. Germany Report No.: LPT 24875 Date: 2010-06-03 GLP: yes unpublished

2010b IIA, Examination Of Glyphosate TC In The HAG 5.2.6/02 Skin Sensitisation Test In Guinea Pigs According To Magnusson And Kligman (Maximisation Test) ZFZ Zzh*:)äく)g üI Fcfb7g぀zebt_ 1゛c /8t1Eョ§ä9゜゛YÖ龼龾ゕd, DV. Qe龼( ョ7x, Germany Report No.: 24879 Date: 2010-01-22 GLP: yes unpublished 2009d IIA, Examination of Glyphosate TC in Skin HAG 5.2.6/05 Sensitisation Test in Guinea Pigs according to Magnusson and Kligman (Maximisation Test) ZSL z§cl!Zhfh9 q- Sxz぀c3yfäi3゜ kくc Z7_9:zk:2* Ü゗uÄ ゘ ,R゛ .Yヌ ?1h!U龽3, Germany Report No.: LPT 23915 Date: 2009-05-19 GLP: yes unpublished

Page 15 of 192

- 16 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1995 IIA, HR-001: Teratogenicity Study in Rats ALS 5.6.10/02 _La `§lcJl:k/ `b k2oZl)u7぀ale: än.Z7kjく/_゛ L0uq4. Japan Report No.: IET 94-0152 Date: 1995-07-21 GLP: yes unpublished

1979a IIA, Acute Oral Toxicity Study in Rats. BAY M-643922-01-2 5.2.1/12 R5tくz぀j§§/aJ h?-. ・Je4uね0: report BD-77-428 Date: 1979-08-06 GLP: no (pre-GLP) unpublished 1979b IIA, Primary Dermal Irritation in Rabbits BAY M-644080-01-2 5.2.4/10 pe:れgJ$゜ report BD-77-428 Date: 1979 GLP: no unpublished

1995a IIA, HR-001: Primary Dermal irritation study in ALS 5.2.4/03 rabbits $Zä Jit/fく_iz -0 hx9z゜äjZ7l-&l Lö5:y・ztuh. E・v7゛, Japan Report No.: IET 95-0035 Date: 1995-06-28 GLP: yes unpublished 1995b IIA, HR-001: Primary Eye Irritation study in ALS 5.2.5/03 rabbits Z・c -Jilj8/くa 9- (゘くLo$t8dä:?/ ö:givZpäxk. Lyu7q. Japan Report No.: IET 95-0034 Date: 1995-06-29 GLP: yes unpublished 1995c IIA, HR-001: Dermal sensitisation study in ALS 5.2.6/03 Guinea pigs Z7? `l/üJ/:ka k- j!4・龽k:jLp9c? u_jく_3Lblä. Lhxk4, Japan Report No.: IET 95-0036 Date: 1995-06-28 GLP: yes unpublished 1996 IIA, First Revision to Glyphosate Acid: 90 Day SYN 5.3.3/04 Oral Toxicity Study in Dogs ゕceg/`/ yjn/4öLくa§ z(/-ni73zu. ? ダi9ftq .Fz!9 zä(/゜ヸ?ä:Jjä. B1?Ju/I.a UK Report No.: CTL/P/1802 Date: 1996-11-14 GLP: yes unpublished 1995 IIA, HR-001: A Teratogenicity Study in ALS 5.6.11/01 Rabbits ?L_ fJtlq0/ä `゛ Tョ:぀゜)・§zy/?j §5te゜ nZibd. しjfIJ.p7??6j ö4Zx1, Japan Study no.: IET 94-0153 Date: 1995-07-21 GLP: yes unpublished

Page 16 of 192

- 17 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2008 IIA, Glyphosate Technical – Micronucleus SYN 5.4.4/07 Assay in Bone Marrow Cells of the Mouse BR.R B9/i?J/u ?ゕtj z)BJzczp D.N龿* ゕJ4uJ1!!. Germany Report No.: 1158500 Date: 2008-06-09 GLP: yes unpublished 1996a IIA, Glyphosate acid: Acute neurotoxicity SYN 5.7.1/01 study in rats Tpäc?? R/z:a0- z゛udLöülib äuciTpI*I0. Dt)/hcä7 !ョF? ヸa?J)j0.zi?:z Rl)cv?J゜, UK Report No. CTL/P/4866 Date: 1996-03-01 GLP: yes unpublished 1996b IIA, Glyphosate Acid: Subchronic SYN 5.7.4/01 Neurotoxicity Study In Rats ?äEa゛e Bxj(ää/ 7zkLkl1/1* :゜Z?u1)z§). ロ :)iq9a S?-.d ヸzjzJjez`a/6. ゕ2vjcaJf, UK Report No.: CTL/P/4867 Date: 1996-03-11 GLP: yes unpublished

1982* IIA, 21-Day dermal toxicity study in rabbits BAY M-643926-01-2 5.3.7/01 ?(z:3t!öi2t4? Cäc`ä4zJ cpく Üqc゛ :cztgq& 0)゛lt49.ゕ_(c 4tれ/e§e゜ USA J?uヸyu6l Report No. IR-81-195 Date: 1982-03-10 GLP: no (pre-GLP study) unpublished 1997 IIA, Glyphosate Acid: Eye Irritation to the SYN 5.2.5/11 Rabbit h`Bc/ej L2lgj*7äd8 Zc6u(ei゛-v. み??eJ:c/ta!2, UK Report No.: CTL/P/5138 Date: 1997-03-18 GLP: yes unpublished 1995 IIA, HR-001: 13-week Subchronic Oral ALS 5.3.2/04 Toxicity Study in Rats Zn? (üJ/j:ldä 7I L8!ä:cj9:bq゗$ 9/9vLn?§i8. Lb_*.* Japan Report No.: IET 94-0138 Date: 1995-07-20 GLP: yes unpublished

1996 IIA, [14C]-Glyphosate: Absorption, NUF 5.1.1/02 distribution, metabolism and excretion following oral administration to the rat R89:x(ü K:ain?aö 8.T)$゜a Ö-.e-4_ejz A*j`ü ロJ3!4-ョ/c, UK Report No.: 1413/2-1011 Date:1996-10-23 GLP: yes unpublished

Page 17 of 192

- 18 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1995 IIA, HR-001: Acute inhalation toxicity study in ALS 5.2.3/02 rats Z?ö `Jlti8l・c 2- j`izT5öyy゘ägi 2/uE*gta゜*, Japan Report No.: IET 94-0155 Date: 1995-06-15 GLP: yes unpublished 1996 IIA, 5.8/01 AMPA: Acute Oral Toxicity Study In ALS Mice. Lcu rョJi/v/ia n- ゜lョ?7LhI゜龾:z/ d/§.Eoeくtüö Dl0üc(z(Jgj. E゛・1b, Japan Report No.: IET 96-0075 Date: 1996-11-11 GLP: yes unpublished 1995a IIA, HR-001: Acute Oral Toxicity Study In ALS 5.2.1/02 Rats. 3aL fxJl:j§jz (ョ `b゗aeTy゜tq5lj Lubätyョn.t7 z(J_/Dbu/Ic. v$Z78, Japan Report No.: IET 94-0134 Date: 1995-02-20 GLP: yes unpublished 1995b IIA, HR-001: Acute Oral Toxicity Study In ALS 5.2.1/03 Mice. Exc lll(vJ/゛a `_ L§6)6゗8ijk?:c Zpv?7i3lü6. zj)I・.し18äJl L5x*p, Japan Report No.: IET 94-0133 Date: 1995-02-20 GLP: yes unpublished

1995c IIA, HR-001: Acute dermal toxicity study in ALS 5.2.2/03 rats Läö )j1?*J:// Iく l-・龽?tT0$3djz E:ョ7゜gaj0*. Japan Report No.: IET 94-0154 Date: 1995-03-14 GLP: yes unpublished 2001 IIA, Carcinogenicity Study with Glyphosate FSG 5.5.3/01 Technical in Swiss Albino Mice eüdZ6utt9_ ?-l゗*lHvcä ejBijJ cJceedゕI fRz8iz. e/tJゕi vtrbä Ttjく゘/ä. zöS?$? `- ?J?.Sq ゕ?x.6?/df? *qく b_3 India Study No.: Toxi: 1559.CARCI-M Date: 2001-10-10 GLP: yes unpublished

1995 IIA, HR-001: 13-week Oral Subchronic ALS 5.3.2/05 Toxicity Study in Mice Z゜z uJ:c!li7l rö /I9&?:Lvd1?§j k2/ügbxZe/. Zgö*ö, Japan Report No.: IET 94-0136 Date: 1995-07-24 GLP: yes unpublished

Page 18 of 192

- 19 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1995 IIA, HR-001: In vitro cytogenetics test ALS 5.4.2/01 Eoz `::üJ::bä 0- Zy/3:ätq!ug龽z *lt.Zö?9くq゜ Eö7n*. Japan Project No.: IET 94-0143 Date: 1995-05-29 GLP: yes unpublished

1981* IIA, A Lifetime Feeding Study BAY M-645914-01-2 5.5.2/05 of Glyphosate (ROUNDUP Technical) in Rats tqiく?zJゕh3぀/ (ä,゛. し5tl1§jJ d) C:töh ・ö cuo )Fzzjü ueeyL/qjlh. LJ?i tJ:bvaれ :i, New Jersey Study/Project No.: 77-2062 Date: 1981-09-18 GLP: no unpublished

1988 IIA, 5.8/02 Aminomethyl Phosphonic Acid: Acute SYN Oral Toxicity to the Rat. rfB av:`/B? z/hL・ylhö8 x:9Tzh(e゜`. tz1O$`t? F?゛f ?J:hねc?äjI:a. §ap`äゕJj, UK Report No.: CTL/P/2266 Date: 1988-08-10 GLP: yes unpublished 2009a IIA, Acute Dermal Irritation/Corrosion Test HAG 5.2.4/02 (Patch Test) of Glyphosate TC In Rabbits TFZ Zä0q7`n!cl 6) bc龾?zbョF`゛:4 zu7 E$thad:bョp QV龼x ゘ Rg, O.V Ycf龿d゜ 2, Germany Report No.: 24877 Date: 2009-11-27 GLP: yes unpublished 2009c IIA, Acute Dermal Irritation/Corrosion Test HAG 5.2.4/04 (Patch Test) of Glyphosate TC in Rabbits TSZ Tä-/vü゜ä2I y` xäe_:S)龾ä6*9 e82 L1/q0papjk ダU龽9 龿 Rx, Hw. Ä龾60äp-, Germany Report No.: LPT 23913 Date: 2009-04-30 GLP: yes unpublished 2010a IIA, Acute Dermal Irritation/Corrosion Test HAG 5.2.4/05 (Patch Test) of Glyphosate TC in Rabbits EEF e゜・e/nT(!d n( efe2iSd゗?§no c§n $3atg_゛Llョロ぀ョし぀ゕx, GÜ. IÜc぀1ob, Germany Report No.: LPT 24605 Date: 2010-01-06 GLP: yes unpublished

Page 19 of 192

- 20 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2009b IIA, Acute Eye Irritation/Corrosion Test Of HAG 5.2.5/02 Glyphosate TC In Rabbits TSL ci`Zänu)3く 1) x(぀?a$゜bF?jo *c4 E$?ョx89tu: しyし龼龾 ,ゕx Ö.V Q龾xov?`, Germany Report No.: 24878 Date: 2009-11-27 GLP: yes unpublished 2009d IIA, Acute Eye Irritation/Corrosion Test of HAG 5.2.5/05 Glyphosate TC in Rabbits ZFE T・*fxey-?j ur ?ep:üS゜`龼z゜゜ g?g Z3luj゛ekoq イ぀U4 ゗ 3,B NA. Ue゘゛`kg, Germany Report No.: LPT 23914 Date: 2009-04-30 GLP: yes unpublished 2010b IIA, Acute Eye Irritation/Corrosion Test of HAG 5.2.5/06 Glyphosate TC in Rabbits EFZ ゛3IcョTcj・( ゛( Sz!龽ä7くäpj゛4 ?ux ゛0lägiョL75 龿$OO 龽 Bp, ダ.Y 龾゜ Nzo_-. Germany Report No.: LPT 24606 Date: 2010-01-06 GLP: yes unpublished 2002a IIA, 5.8/03 Acute Toxicity Study of AMPA FSG (Aminomethyl Phosphonic Acid) in CD Rats by Dermal Administration – LIMIT TEST TSL T)-゜z§yzih 4! Fä!぀?ョkxä:d4 ?18 E/ü/17g1?ö じ龽・w ゗ゕ,v イ.H Aö.c龿2(h Germany Report No.: 16168/02 Date: 2002-12-03 GLP: yes unpublished 2002b IIA, 5.8/04 Examination of AMPA (Aminomethyl FSG Phosphonic Acid) in the Skin Sensitisation Test in Guinea Pigs according to Magnusson And Kligman (Maximisation Test) ETS p?/kZz7-7( ü- Fk?-゗7u??0:§ e20 Lgtz1kö3ty Ynじ& 龾 §,ゕ AU. Ökく .?龾8! Germany Report No.: 16169/02 Date: 2002-12-03 GLP: yes unpublished 2008 IIA, Skin Sensitisation Test for Glyphosate HAG 5.2.6/09 Technical in Guinea Pigs. Buehler Test. Ct(:0z* c9ü!`Zcj3/hJ, Brazil Report No.: RF-3996.318.431.07 Date: 2008-09-30 GLP: yes unpublished

Page 20 of 192

- 21 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1996 IIA, Glyphosate acid: Biotransformation in the rat SYN 5.1.3/03 yRcj-z/ Lpb/eüinn$ T0z:n).znIv z ゛れeaiäJ(:aj. JötB2z(z, UK Report No.: CTL/P/5058 Date: 1996-06-28 GLP: yes unpublished

1995 IIA, HR-001: Metabolism in the rat ALS 5.1.1/01 N_ij・g4v_1 JcC??`e7 Bc(?o/ jEp,. Kp6kd゛.jthd Rz぀-**ü:hcJtIz, UK Report No.: SNY 332/951256 Date:1995-08-16 GLP: yes unpublished

2005a IIA, Glyphosate Acid Technical – Acute Oral HAG 5.2.1/08 Toxicity Up and Down Procedure in Rats Ff・2゛zj c`a/1P Zu)l/eくzkfcJ. Y:.eöho ws, US Report No.: PSL 15274 Date: 2005-04-04 GLP: yes Unpublished

2005b IIA, Glyphosate Acid Technical: Acute Dermal HAG 5.2.2/08 Toxicity Study in Rats – Limit Test `vSghzi ccP`l7 Izく!:JTä゜3ia. aしV sf?zJ§, USA Report No.: PSL 15275 Date: 2005-04-04 GLP: yes unpublished

2005c IIA, Glyphosate Acid Technical: Acute HAG 5.2.3/07 Inhalation Toxicity Study in Rats – Limit Test §pSI1z: :FcIä_ ZeくIetJ.h/2`? しU? s-cJäv, USA Report No.: PSL 15276 Date: 2005-04-04 GLP: yes unpublished

2005d IIA, Glyphosate Acid Technical – Primary Skin HAG 5.2.4/07 Irritation Study in Rabbits qS)゛゜el räiFcg Zf?jc.e9゜/7!J V?O IJsäa4, USA Report No.: PSL 15278 Date: 2005-04-04 GLP: yes unpublished

2005e IIA, Eye Irritation/Corrosion Effects in rabbits HAG 5.2.5/08 (Oryctolagus cuniculus) of Glyphosate 95 TC 90ö?:S` ?-:Fzv ä$?iく?.E3()lJ äしÜ )cdscJ, USA Report No.: PSL 15277 Date: 2005-04-04 GLP: yes unpublished

Page 21 of 192

- 22 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2005f IIA, Glyphosate acid technical – Dermal HAG 5.2.6/08 Sensitization in Guinea Pigs (Buehler Method) ga/FI13 -a/Jc゛ E?5`epJ.゜:I:? AG? fäs?Jョ , USA Report No.: PSL 15279 Date: 2005-04-04 GLP: yes unpublished

1995a IIA, HR-001: Reverse Mutation Test ALS 5.4.1/01 The Institute of Environmental Zvjzonb9tk. k.E8nq Japan Project ID: IET 94-0142 Date: 1995-04-03 GLP: yes unpublished

1995b IIA, HR-001: DNA Repair Test (Rec-Assay) ALS 5.4.3/02 pzE 3/l:ärJlü ゛I Ljnz・ii§8)0龾ä ü__5üE゛:äi. 64Zk1, Japan Project No.: IET 94-0141 Date: 1995-03-14 GLP: yes unpublished

1996 IIA, 5.8/06 AMPA, Reverse Mutation Test ALS Evä ・tiojfJl? ゛r Lt24龽ü?t8ョIäl Ev//52ä8*x. Z1゜v0, Japan Report No.: IET 96-0076 Date: 1996-12-09 GLP: yes unpublished

1996 IIA, Glyphosate Acid: One Year Dietary SYN 5.5.1/01 Toxicity Study in Rats ゕäg/`i? E4t1ö99:ap c?・föZ4b`i. Nj`く$aja !Szョヸ?Jat.?ziz)j3 1aJRくj-a, UK Study No.: CTL/P/5143 Date: 1996-10-02 GLP: yes unpublished 2008 IIA, Evaluation of the mutagenic potential of HAG 5.4.1/06 the test substance Glyphosate Technical by reverse mutation assay in Salmonella typhimurium (Ames Test) tu9ゕ?)/ Eeョ!ä-/ョ・:゛J T:x?., Brazil Report No.: RF- 3996.401.392.07 Date: 2008-09-15 GLP: yes unpublished 1999 IIA, NUP5a99 62% glyphosate MUP: Acute NUF 5.2.1/17 oral toxicity study in rats – Limit test Söi)ョ*a Jz)a:゜ E5Jc. イzÖ saJäd-, USA Study No.: 7907 Date: 1999-09-16 GLP: yes unpublished

Page 22 of 192

- 23 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2000 IIA, Glyphosate acid: Multigeneration SYN 5.6.1/02 reproduction toxicity study in rats /BAY RcüleiI u?3tk9E§j2 Ezv?:f3fu*. れe`.?ejaJtcjy RzJ:ä§・I, UK Report No.: CTL/P/6332 Date:2000-06-16 GLP: yes unpublished

1996b IIA, Glyphosate acid: Developmental Toxicity SYN 5.6.10/01 Study in the Rat Rcü//!c L7j6kq8/z゜ Zc7$!i5.ä(8 みä?tä):ä6äJ:, UK Report No.: CTL/P/4819/Amendment-001 Date: 2002-11-20 GLP: yes unpublished 1996a IIA, Glyphosate acid: Developmental toxicity SYN 5.6.11/03 study in the rabbit B-c7:e: Ey/$1pbjax zくe/u(ョ Tkf. zz?/1.ヸ?ätJ!: Ryc.・zJj` UK Report No.: CTL/P/5009 Date: 1996-07-02 GLP: yes unpublished 2011 IIA, Glyphosate Technical – Acute inhalation SYN 5.2.3/11 Toxicity Study (Nose-only) in the Rat ゕTY ゕJa?!aeu T:_,. Jd!e龼Kää, Hungary Report No.: 11/054-004P Date: 2011-06-06 GLP: yes unpublished 1997 IIA, HR-001: 12-Month Oral Chronic Toxicity ALS 5.3.4/02 Study in Dogs Z_? J/liz`*3: k- L$-c゛/:ü/py぀z L7jgi・0zd1. L・51g, Japan Report No.: IET 94-0157 Date: 1997-05-20 GLP: yes unpublished 2002 IIA, 5.8/07 Measurement of unscheduled DNA synthesis ALS (UDS) in rat hepatocytes in vitro procedure with AMPA (Amino methyl phosphonic acid). Jjoifp:/ SeaIJ/k Aä Z:?ij. Aäcyi:? §g?i3El3n3 Eä(cj(2§p5j T/;/a. France Report No.: IPL-R 020625 Date: 2002-09-10 GLP: yes unpublished

1993* IIA, 90 day range finding study of glyphosate in ALK 5.3.2/02 rats EPf :jB?・r?o bz.Zäö-lö`jcJ Äc(・0J?J, USA Project No.: 011-0001 Date: 1993-11-18 GLP: yes unpublished

Page 23 of 192

- 24 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1996 IIA, Glyphosate acid: 21-day dermal toxicity SYN 5.3.7/04 study in rats zfB゜ici L5く:b$*0/? ä2e.En`jüIö ???ia!:ヸJc/6, UK Report No.: CTL/P/4985 Date: 1996-06-24 GLP: yes unpublished 1999 IIA, Subchronic (90 Day) Oral Toxicity Study FSG 5.3.3/02 With Glyphosate Technical In Beagle Dogs AND Test compound stability in experimental diet (dog feed) ゕä/jJj ゕaJäzIzü ä/.R§(z zfcCäh7t_, India Study No.: 1816 AND 1817-R.FST Date: 1999-04-17 AND 1997-02-21 GLP: yes unpublished

1996 IIA, Glyphosate Acid: 4-Hour Acute Inhalation SYN 5.2.3/10 Toxicity Study in the Rat 5j?F゜・$ä ョietゕ?) _:äjüくZ48゜ E98)c/)xz4. Otäf・o/ Se`5. ねz:ääj$.?zJr: ゕ J0cüät(, UK Report No.: CTL/P/4882 Date: 1996-04-29 GLP: yes unpublished 1988b IIA, Primary Dermal Irritation Study of BAY M-645016-01-2 5.2.4/09 Glyphosate Batch/lot/nbr no. XLI-55 in New Zealand White Rabbits ヸü5Jeul0 report FD-88-29 (FDRL 88.2053.010) Date: 1988 GLP: Unpublished

1988c IIA, Primary Eye Irritation Study of Glyphosate BAY M-644177-01-2 5.2.5/10 S78b m Qく`* ゜`cJzz(ä ukzüZ?)i(jzJ, USA oJヸhc・:v report: FD-88-29 (FDRL 88.2053.009) Date: 1988 GLP: no (pre-GLP) unpublished

1988a IIA, Acute Oral Toxicity Study of Glyphosate BAY M-645904-01-2 5.2.1/11 Batch/lot/nbr no. XLI-55 in Sprague- Dawley Rats. ySv8 z゜q ロ0(く BJfea??§ e3ü`z`aJT/_t, USA 9・15ヸJä: report FD-88-29 (FDRL 88.2053.007) Date: 1988-06-08 GLP: yes unpublished

Page 24 of 192

- 25 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1990* IIA, Two Generation Reproduction Feeding Study BAY M-643937-01-2 5.6.1/07 with Glyphosate in Sprague-Dawley Rats 8dみhJ?4j üI:tb(e/Öexj Reyo_぀g. Z$)龿1cj4/pq?i Ö?iläd *4)3(6.Zze/ 0ョ7 ,P Ja.Vcイiä゜ ,P: 9j.ZpJ れjJv・(jJ üpö6o Report No.: MSL-10387 Project No.: ML-88-106/EHL 88038 Date: 1990-08-27 GLP: yes unpublished 2007 IIA, Bacterial reverse mutation test (Ames HAG 5.4.1/05 Test) for Glifosato Técnico Helm LRダみZ pZzeöd゛/v/c /a:G゗qq:ä El§e. Brazil Report No.: 3393/2007-2.0AM-B Date: 2007-12-13 GLP: yes unpublished

2006 IIA, Glyphosate Technical: Skin Sensitisation in NUF 5.2.6/10 the Guinea Pig – Magnusson and Kligman Maximisation method Fz?_üd- lゕ6 ヌj5龾zgja8a2ü. France Study No.: SMK-PH-05/2018, Report No.: 2060/009 Date: 2006-01-13 GLP: yes unpublished

1981* IIA, A three generation reproduction study in BAY M-644052-01-2 5.6.1/05 rats with glyphosate ・n龼tJR::kくcz (くz,. J/Z? み:ijd.tJka ÜäÖ sfJäö.z USA Study No.: 77-2063; BDN 77-417 Date: 1981-03-31 GLP: no, pre-GLP unpublished 2009a IIA, Glyphosate Technical: Acute oral Toxicity EXC 5.2.1/04 Study in Rat, C22864, GLP, Unpublished N)zt?* Z65/yfäJ?(?: T,/b. *lü(-St:gJb, Switzerland Report No.: C22864 Date: 2009-04-02 GLP: yes unpublished

2009b IIA, Glyphosate Technical: Acute Dermal EXC 5.2.2/04 Toxicity Study in Rat O:6?Ic EgjJc2I?3(/? Zl5,. Sjl9Jn`.§i§I , Switzerland Report No.: C22875 Date: 2009-04-02 GLP: yes unpublished

Page 25 of 192

- 26 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2009c IIA, Expert Statement EXC 5.2.5/04 Glyphosate technical: Primary eye irritation study in rat Gää6f/ T6ö(?laäi0(J E/く,. t:j3J7y!P5), Switzerland Report No.: C22897 Date: 2009-01-23 GLP: yes unpublished 2009d IIA, Glyphosate Technical: Contact EXC 5.2.6/04 Hypersensitivity in albino guinea pigs – Maximization-Test Üäjくfc Zeunex!:aJf/ /Z1, P/*J゜x_ti-!, Switzerland Report No.: C22908 Date: 2009-05-15 GLP: yes unpublished 2007a IIA, Salmonella typhimurium and Escherichia NUF 5.4.1/02 coli Reverse mutation assay with Glyphosate technical (NUP-05068) ゕBB :,Z_. )t20i1a, Switzerland CRR Study No.: 1061401 Date: 2007-03-16 GLP: yes unpublished 2007b IIA, Salmonella typhimurium and Escherichia NUF 5.4.1/03 coli Reverse mutation assay with Glyphosate technical (NUP-05070) Bゕゕ Tu,.l rjョc.j8ö Switzerland ゕRR Study No.: 1061402 Date: 2007-03-16 GLP: yes unpublished 2007c IIA, Salmonella typhimurium and Escherichia NUF 5.4.1/04 coli Reverse mutation assay with Glyphosate technical (NUP-05067) RBC Eh.:, (/§l2ab. Switzerland BゕB Study No.: 1061403 Date: 2007-03-16 GLP: yes unpublished 2010 IIA, Salmonella typhimurium and Escherichia coli HAG 5.4.1/09 Reverse Mutation Assay with Solution of Glyphosate TC spiked with Glyphosine e/w`c_ B・iJ6/ci B?ji JäCaäe-゜し぀く Q `äV?`/2 ゕ-.RC pü(.CJJö` Germany Study No.: 1332300 Date: 2010-04-07 GLP: yes unpublished

2009 IIA, Glyphosate technical – Salmonella SYN 5.4.1/13 typhimurium and Escherichia coli Reverse Mutation Assay e・X?I: R2jqicJ: :Ra: äJc?.Cz-6 C§J)Jq6f, Germany Report no.: 1264500 Date: 2009-12-18 GLP: yes unpublished

Page 26 of 192

- 27 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1990* IIA, Chronic study of Glyphosate administered in BAY M-651388-01-2 5.5.2/06 feed to Albino rats れ2?k9pJ/ 0/?くj:xヌI-ei ゕkx.぀zo0 ,Pj Zk8/J. J!.ね:J*8/ USA Study No.: MSL-10495 Date: 1990-09-26 GLP: yes unpublished 1997 IIA, HR-001: 18-Month Oral Oncogenicity ALS 5.5.3/03 Study in Mice Z・? くJlic)i/6 く! p:§cpe/Z゛!*゘i gläi$Ennk2. bZ$p7, Japan Project No.: IET 940151 Date: 1997-06-18 GLP: yes unpublished

1996* IIA, Combined Chronic Toxicity and FSG 5.5.2/01 Carcinogenicity Study with Glyphosate Technical in Wistar Rats jJCäjt ゕaJ??(e9 v-.ゕ?:a e/::JC e!*0l u,.El Czョu-a6ci, India Study No.: 886.C.C-R Date: 1996-07-18 GLP: yes unpublished 1993a IIA, Two Generation Reproduction Study in FSG * 5.6.1/04 Wistar Rats. $znv゛Ld:/8 ヌeIla9/.z2龿 Ct/lcJ )_töc Z:,.* /jC?:J X)z/$2?゜぀täe zJゕ?eIz3 8Pl?i:0. C*Iz.eoctn India Study No.: TOXI 885-RP-G2 Date: 1993-08-27 GLP: yes unpublished

1993b IIA, Teratogenicity study in rabbits – Test FSG * 5.6.11/06 compound: Glyphosate technical (FSG 03090 H/05 March 1990) CJzjtj -_lkc ::yE゗iz. BtJäit ロ *!70zee龾jäj ?-zB?Jäb zvPll:b. Rz$?q゜t`c, India Study No.: TOXI: 884-TER-RB Date: 1993-04-17 GLP: yes 1997 IIA, HR-001: A two -generation reproduction ALS 5.6.1/03 study in rats Eü? Jjjj!ui0ä ョ- 5fd・぀/T6jz゛/e Eq:97.5/a゛2 L4ud1, Japan Study No.: IET 96-0031 Date: 1997-06-19 GLP: yes unpublished 2007a IIA, GLYPHOSATE TECHNICAL (NUP05068) NUF 5.2.1/10 : Acute oral toxicity study in rats BBR Z,l3 l0:L83z87v. B)8_1Nh S2iy`(.itJ49 Switzerland Report No.: BO2272 Date: 2007-03-01 GLP: yes unpublished

Page 27 of 192

- 28 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2007e IIA, GLYPHOSATE TECHNICAL (NUP05068): NUF 5.2.2/10 Acute dermal toxicity study in rats BRB Tv,.i *_xョ.L/ä0t* S6/oJq)Ij/§. Switzerland Bゕゕ Study No.: B02283 Date: 2007-03-01 GLP: yes unpublished 2007d IIA, Glyphosate Technical (NUP 05068): NUF 5.2.4/01 Primary Skin Irritation Study in Rabbits (4-Hour Semi-Occlusive Application) CRゕ Ejü., 08a:xョ.Llv* RI7kじ7_ Pt:of)$tJn7 j Switzerland ゕCゕ Study No.: B02294 Date: 2007-03-01 GLP: yes unpublished 2007b IIA, Glyphosate Technical (NUP 05068): NUF 5.2.5/01 Primary Eye Irritation Study In Rabbits BBゕ T,.jü Z゛pz゛・./゜:3 Rロh*!1$ /kJS゜:l6d)r / Switzerland CRB Study No.: B02305 Date: 2007-03-06 GLP: yes unpublished 2007c IIA, Glyphosate Technical (NUP 05068): Contact NUF 5.2.6/01 Hypersensitivity in Albino Guinea Pigs, Maximisation Test ゕゕB Ti,v. 35j・Ldla゜・. 8bゕÄrh6 iit$JpyP0)! t Switzerland CBB Study No.: B02316 Date: 2007-03-06 GLP: yes unpublished 1980* IIA, Technical Glyphosate: Teratology study in BAY M-644182-01-2 5.6.11/04 rabbits faz_j8/)$jjvä C?Jäc)?9 cnq 1zi1äじ ?7龾2j xbbäゕ--i/くq. jo.れag:5ä USA ね 4ü9iJek Report No.: IR-79-018 Date: 1980-02-29 GLP: no (pre-GLP study) unpublished 2011a IIA, Glyphosate technical – Acute Oral Toxicity SYN 5.2.1/15 Study in the Rat (Up and Down Procedure) ゕTw aJ)z3ゕz? Z,.ip Hungary Report No.: 10/218-001P Date: 2011-04-15 GLP: yes unpublished 2011b IIA, Glyphosate Technical – Acute Eye SYN 5.2.5/13 Irritation Study in Rabbits RE ダ BJcx?ä(? Ej゜., Hungary Report No.: 10/218-005N Date: 2011-05-13 GLP: yes unpublished

Page 28 of 192

- 29 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1996 IIA, Technical glyphosate: Reverse mutation NUF 5.4.1/11 assay “Ames test” using Salmonella typhimurium and Escherichia coli FakzI龼e!q Tlくt.z§9(z!aJ Ä**?I, UK SPL Project No.: 434/014 Date: 1996-02-20 GLP: yes unpublished

1994a IIA, Glyphosate technical (Alkaloida, BAY M-651166-01-2 * 5.3.7/03 Tiszavasvári): Repeated dose twenty- eight- Day dermal toxicity study in rabbits くj(Jtj8/z hr axE?0*3j*0. Q788ry a:wJ?/d?3, Hungary Report No.: MÜF 214/94 (Test Code: GLY-94-410/N Date: 1994-08-30 GLP: yes unpublished

2011 IIA, Glyphosate technical – Local lymph node SYN 5.2.6/13 assay in the mouse – Final report amendment 2 VTC JbBaääIz b,T/. Hungary Report No.: 10/218-037E Date: 2011-04-21 GLP: yes unpublished

2010 IIA, Reverse Mutation Assay using Bacteria HAG 5.4.1/10 (Salmonella typhimurium) with Glyphosate TC PRE t_!:?CJ?4? jqPecll-le E89)z゜!jäiaJ Q゘_Ü. Ftzp?oq, Germany PゕT study No.: BSL 101268 Date: 2010-04-08 GLP: yes unpublished

2010a IIA, 450 g/L Glyphosate SL Formulation BAY M-644727-01-2 5.9.9/01 (MON 79545) – In vitro absorption of glyphosate through human epidermis Yä)龿:? /9_゜za6i゜0 e?-§T・v)jü. Nz/?z. UK Report No.: JV2083-REG Date: 2010-02-19 GLP: yes unpublished

2010b IIA, 480 g/L Glyphosate SL Formulation BAY M-651163-01-2 5.9.9/02 (MON 79351) – In vitro absorption of glyphosate through human epidermis V!぀zej iz/nx4aög1 Ez4f:ü`0ä6. wääjc, UK Report No.: JV2085-REG Date: 2010-02-19 GLP: yes unpublished

1999 IIA, NUP5a99 62% glyphosate MUP: Acute NUF 5.2.3/12 inhalation toxicity study in rats – Limit test 1öF)päl äkJ!?: cJTd. ロUz sä`Jä8, USA Study No.: 7909 Date: 1999-09-16 GLP: yes unpublished

Page 29 of 192

- 30 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1996 IIA, Glyphosate Technical: Pharmacology NUF 5.10/03 Screening Study in the Rat P93z`龾e!a 0§!:aZec:1(J :§,.Z Na4Iョ, UK Study No.: 434/021 Date: 1996-06-28 GLP: yes unpublished

2009a IIA, Glyphosate Technical: Dietary combined NUF 5.5.2/08 chronic toxicity / carcinogenicity study in the rat 6D?)ie )äiIjTzn6g?J jt゜Z龾i?, UK SPL Project No.: SPL2060-0012 Date: 2009-04-23 (amended: 2009-05-08) GLP: yes unpublished

2009b IIA, Glyphosate Technical: Dietary NUF 5.5.3/02 carcinogenicity study in the mouse イ?:k)z Ee0)?゜IJn::ä a゛Tj&:i, UK Report No.: SPL 2060-0011 Date: 2009-04-09 GLP: yes unpublished 1996 IIA, Technical glyphosate: Chromosome NUF 5.4.2/02 aberration test in CHL cells in vitro ä)zh龾Fkz( Ez゜)j2?.k?-:J ÖäkI2, UK SPL Project No.: 434/015 Date: 1996-03-13 GLP: yes unpublished

1996 IIA, HR-001: 13-week Oral Subchronic ALS 5.3.3/03 Toxicity Study in Dogs 2cE (Jjjjl56ä p! Zö/`q゘i?:ョbcb du:.E*/zö23 §nLy$. Japan Report No.: IET 94-0158 Date: 1996-09-05 GLP: yes unpublished 2009a IIA, Glyphosate: Acute Oral Toxicity Study HAG 5.2.1/01 (UDP) In Rats. ゗aしFllijz4ü. `0ä,. q_eF( Zä6§. ZY, US Report No.: 12170-08 Date: 2009-03-11 GLP: yes unpublished 2009b IIA, Glyphosate – Acute Dermal Toxicity HAG 5.2.2/02 Study in Rats P/?3j/i龽z_G ,.`3ä äcZgJ. USA Report No.: 12171-08 Date: 2009-03-11 GLP: yes unpublished

2009c IIA, Glyphosate – Acute Dermal Irritation HAG 5.2.4/06 Study in Rabbits /67NP:jj゗?ä -?,.d cdäZJ, USA Report No..: 12173-08 Date: 2009-03-11 GLP: yes unpublished

Page 30 of 192

- 31 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2009d IIA, Glyphosate – Acute Eye Irritation Study in HAG 5.2.5/07 Rabbits j぀a゛゜F:j:?G ä-0,. Ez?6J, USA Report No.: 12172-08 Date: 2009-03-11 GLP: yes unpublished

2009e IIA, Glyphosate – Skin Sensitization Study in HAG 5.2.6/07 Guinea Pigs. Buehler Test. Pit龼?/j?25じ 0a,). Zbc?J, USA Report No.: 12174-08 Date: 2009-03-11 GLP: yes unpublished

2011a IIA, Glyphosate Technical – Acute Dermal SYN 5.2.2/13 Toxicity Study in Rats – Final Report Amendmend 1 TヌC 4B?J?c`ä .Elp, Hungary Report no.: 10/218-002P Date: 2011-04-13 GLP: yes unpublished

2011b IIA, Glyphosate Technical – Primary skin SYN 5.2.4/13 irritation study in rabbits – Final report Amendment 1 EwC JäaBcz)8 j,.E* Hungary Report No.: 10/218-006N Date: 2011-04-13 GLP: yes unpublished

2007 IIA, Mammalian Erythrocyte Micronucleus HAG 5.4.4/03 Test for Glifosato Técnico Helm LじねEゕ Ea?jョ$hög/c N龿däo/?jj Elp,? Brazil Report No.: 3393/2007-3.0MN-B Date: 2007-12-13 GLP: yes unpublished

Page 31 of 192

- 32 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1985 IIA, 5.6.1 Three-generation reproduction study in rats ALK * with the oral administration of glyphosate 3laく:y:Eh・zc: /(elpeく7g` `_ F:ä5: Fal)_:cj_ü ä27 O-龿aäjn2z゛c/ R?2:(ä, Hungary Report No.: not reported Date: 1985 GLP: no (pre-GLP) unpublished

1989 IIA, 5.3.1 Glyphosate 4 Week Dietary Toxicity Study in CHE * Rats f2IJoqä? CcJcz`ä9 `゜ia6?j0/-:ü? T/ö,. äväöPi:4. UK IRI Project No.: 437462, Report No.: 5626 Date: 1989-01-18 GLP: no (GLP-like; pre-GLP) unpublished 1993 IIA, 5.5.3 Glyphosate 104 Week Dietary CHE b* Carcinogenicity Study in mice (3Jna)z・ cc8CcJf? (lä)e/üo?§_tt, Scotland Report No.: 7793 Date: 1993- GLP: yes unpublished

1984 IIA, 5.2.6 A closed-patch repeated insult dermal BAY M-645376-01-2 * sensitization study in guinea pigs (modified Buehler method) Project No.: 4989-84, Report No.: BD-84- 046 Date: 1984-12-18 GLP: no (pre-GLP) unpublished

1988 IIA, 5.2.3 Acute inhalation study of Mon-8750 BAY/ CHE * technical üJみhzh:* Ly6, wläzi゜ Z・5`zb(c/n. Pl, 7tJEb, USA Project No.: EHL 87147, Report No.: ML- 87-228 Date: 1988-04-18 GLP: yes Unpublished

1988 IIA, 5.7. Report on a 21 day oral neurotoxicity study in Luxan * domestic hen of Glycel 41 SL !ün:ä3 )J/_/ui:c q( Züt?y31.§j9 5ゕ龽oed, India Report No.: not stated Date: 1988 GLP: no (pre-GLP) unpublished

1985a IIA, 5.3.5 Report on sub acute inhalation toxicity in EXC * rats (14 days) of glyphosate (technical) Report No.: AA-31 Date: not reported GLP: no unpublished

Page 32 of 192

- 33 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1985 IIA, 5.3.7 Subacute dermal toxicity (for 21-days in EXC * rabbit) of Glyphosate Technical of Excel Industries Ltd. -xくl?p !Jitijab_ I* Z5_3l?§j_d. C_龼d?d, India Report No.: not stated Date: 1985 GLP: no unpublished

1987 IIA, 5.7. 21 day oral neurotoxicity in domestic hen of BCL * Glyphosate technical of Excel Industries Ltd. `j4・?p !J/lzbjp/ qI 7:xt.Zgz゜öo ゕ8゗2?ü, India Report No.: not stated Date: 1987 GLP: no (pre-GLP) unpublished

1990 IIA, 5.1.1 Identification of metabolite of Glyphosate EXC * Technical in rat -xp:?く d::j?!J/ü rk) Lbョj9v3.?ki India Report No.: 1087 Date: 1990 GLP: no unpublished 1995 IIA, 5.2.3 Glyphosate: Acute Inhalation Toxicity Study Herbex * four-hour exposure (nose only) in the Rat ?öPzr゜z)龽 ?!eäEo2:ョ):J xZi., UK Report No.: 710/16 Date: 1995-02-22 GLP: yes unpublished

1994 IIA, 5.2.3 Glyphosate Premix: Acute Inhalation Toxicity CHE * Study Four-Hour Exposure (Nose Only) in the Rat P(cx?&ävI Eäc8I0*!l:?J ,Zik N?fun, UK Project No.: 545/39 Date: 1994-07-06 GLP: yes unpublished

1994 IIA, 5.1.1 Glyphosate ADME study in rats FSG * A&M Labor für Analytik und c7゛/jJ龿qJ!1(Jaみz:6bu7. :h.Bbn_ Germany Report No.: A&M 038/94 Date:1994 GLP: yes unpublished

1981a IIA, 5.2.1 Acute Oral Toxicity of MON 0139 to Rats BAY/ CHE * ヸx9Jäklq. Z,1q Äzäj4i 0qE?o9-elIu, USA Report No.: ML-80-261 Date: 1981-03-17 GLP: yes unpublished

Page 33 of 192

- 34 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1981 IIA, 5.2.2 Acute Dermal Toxicity of MON 0139 to BAY/ CHE b* Rabbits みj8uJäxü R§4eョ龽b. P:, ZvJy/, USA Report No.: ML-80-261 Date 1981-03-17 GLP: yes unpublished

1990a IIA, 5.2.1 Acute oral toxicity study in the rat: AGC * glyphosate technical R$j4lzj1zi :9fäIcJeqiuj ät:d``Cie T:ü., Ireland Report No. R231; Project No. AGC- 900823B Date: 1990-08-20 GLP: yes unpublished

1990 IIA, 5.2.2 Acute dermal toxicity study in the rat: AGC b* glyphosate technical Rtbt/9b/?ä e4ü)ä/cElö-J zii/0fRcf Ejh, Ireland Report No.: AGC-900823A Date: 1990-08-23 GLP: no unpublished

1990c IIA, 5.2.4 Acute dermal irritation/corrosion of glyphosate AGC * technical in the rabbit (intact and abraded skin) jcゕくjuh:äi :?Zc゛_IänI:J )0zゕzjjl` T§/., Ireland Report No.: R233 (Project No.: AGC- 900822 A) Date: 1990-08-22 GLP: no unpublished

1990 IIA, 5.2.5 Acute eye irritation/corrosion of glyphosate AGC d* technical in the rabbit Cju?9jくjet Zv_Ij)zäc7lJ R:är!ä/t7 Eiョ, Ireland Report No.: R234; AGC-900822 Date: 1990-08-22 GLP: yes unpublished

1991 IIA, 5.6.10 The Effect of Glyphosate on Pregnancy of CHE b* the Rat vt9oA8l2y§ BJäzä?I8 *f?Ba:. England Report Nos: CHV 43&41/90716 Date: 1991 GLP: yes unpublished

1991a IIA, 5.6.1 Dietary range finding study of glyphosate in CHE * pregnant rats and their juvenile offspring :bじ87/ound CefäqcJz ゕ?ä3if, England Report No.: CHV 42/90619 Date: 1991-05-14 GLP: Unpublished

Page 34 of 192

- 35 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1994 IIA, 5.2.1 Acute oral toxicity (LD50) test in rats SIN * )c(J119z BJ?c?(a§ /.(k, Z(üez_l, Scotland Report No.: 10670 Date: 1994-10-26 GLP: yes unpublished

1987a IIA, 5.2.2 Acute dermal toxicity study of Mon 8722 in BAY/ CHE * New Zealand White rabbits Sb0n ゛$z fg4Ä CekaJc)a ?`?lh.Z・ö-läJ USA ゕPNE Study No.: 9307A, Report No.: FD- 86-430 Date: 1987-01-29 GLP: yes unpublished 1987 IIA, 5.2.2 Acute dermal toxicity study of Mon 8750 in BAY/ CHE b* New Zealand White rabbits 4P4o ・c5 YI゜0 zcfäCJcq ?g:!jE7`c2zJ, USA CSwT Study No.: 9308A, Report No.: FD- 86-431 Date: 1987-01-30 GLP: yes unpublished

1987c IIA, 5.2.4 Primary dermal irritation study of Mon 8750 in BAY/ CHE * New Zealand White rabbits P9h§ m fG3ョゕz?äJ?-y ?ョnfäjh)tz.ZJ USA PロBZ Study No.: 9308A Date: 1987-01-30 GLP: yes unpublished 1987e IIA, 5.2.5 Primary eye irritation study of Mon 8750 in BAY/ CHE * New Zealand White rabbits Report No.: FD-86-431 Date: 1987-01-30 GLP: no (pre-GLP) Unpublished

1977a IIA, 5.1.1 CP 67573 residue and metabolism. Part 13: BAY M-651045-01-2 * The dynamics of accumulation and depletion of orally ingested N- phosphonomethylglycine-14C. みc3く§゜Jl fj§:tダ§aiy(ä Ä:gJy//3. eäCcJä!o z_fjaYz龾y: Report No.: 309 Date: 1977 GLP: no (pre-GLP) unpublished 1977 IIA, 5.1.1 CP 67573 residue and metabolism.Part 9: BAY M-651047-01-2 b* The gross distribution of N- Part IX: phosphonomethylglycine-14C (CP 67573- 14C) in rabbit uJzxxヸyi し`q/üz:bt?i- ダjqJ7k/j. J)pBz?ce V?゗5jä゜`l? Report No.: 298 Date: 1977 GLP: no (pre-GLP) unpublished

Page 35 of 192

- 36 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1973 IIA, 5.8. CP 67573 residue and metabolism. Part 11: The BAY M-651046-01-2 * metabolism of aminomethylphosphonic acid- 14C (CP 50435-14C ) in the laboratory rat. み8büJ?/n I?n/ダョt$/:!c Ä/くlJ゛.l3 zJzzaC(§ ダc4agje-i龿 Report No.: 303 Date: 1973 GLP: no (pre-GLP) unpublished

1989a IIA, 5.2.1 Glyphosate Technical: Acute Oral Toxicity CHE * (Limit) Test in Rats )0gäfäJb ?IBJ?za6 -9l, /龿oZ/:ä. JJ:`れbä3kud, Scotland B(( Report No.: 5883 Date: 1989-06-22 GLP: no (pre-GLP) unpublished 1989c IIA, 5.2.4 Glyphosate Technical: Primary Skin CHE * Irritation Test in Rabbits くpä§)(aJ zJe0C?ä- p?§c/*3äifiIi E゜:. Scotland `B) Project No.: 243268, Report No.: 5885 Date: 1989 GLP: yes unpublished 1989 IIA, 5.2.5 Glyphosate Technical: Primary Eye CHE d* Irritation Test in Rabbits )cfy5aJq ?J?cゕ`?ö (aülziöi!eju8 Ejv, Scotland Report No.: 5886 Date: 1989-07-1 GLP: no (pre-GLP) unpublished 1989e IIA, 5.2.6 Glyphosate Technical: Magnusson-Kligman CHE * Maximisation Test in Guinea Pigs rdz!J6a2 Ba?f8äJa f_I*tiäzjy・ej Zj§., Scotland Report No.: 5887; Project No.: 243268 Date: 1989-07-17 GLP: no (pre-GLP) unpublished

1993a IIA, 5.8. AMPA: Acute Oral Toxicity (Limit) Test in CHE * Rats -2(?J2ba Bc(Jäeäo `dI§:hkci:a?l i,.E9 Scotland. Report No.: 8763 Date: 1993 GLP: yes unpublished

1993 IIA, 5.8. AMPA: Acute Dermal Toxicity (Limit) Test in CHE b* Rats ö`?ü)üzJ BfzJäz?9 (zi/?7ic-k_1i Ziョ., Report No.: 8764 Date: 1993 GLP: yes unpublished

Page 36 of 192

- 37 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1993c IIA, 5.8. AMPA: Magnusson-Kligman Maximisation CHE * Test in Guinea Pigs r_§äJ5`c J??aCa!ョ x-h:crjael§゛t Tiq., Scotland Report No.: 8765 Date: 1993 GLP: yes unpublished 1991 IIA, 5.2.1 Assessment of Acute Oral Toxicity of CHE * Glyphosate technical to Mice P?:$a07, Denmark Report No.: 12321 Date: 1991-01-07 GLP: yes unpublished

1994a IIA, 5.2.1 Glyphosate Premix: Acute Oral Toxicity BAY/ CHE * (Limit Test) in the Rat P`1cahä(぀ Täkxfc:j・IaJ /Zく,. じz(xö, UK Project No.: 545/37 Date: 1994-07-07 GLP: yes unpublished

1994 IIA, 5.2.4 Glyphosate Premix: Acute Dermal Irritation BAY/ CHE b* Test in the Rabbit F(zä゘c$゛) äeaJZu9Ii*I/ Zi・. Hc)öd, UK Project No.: 545/40 Date: 1994-07-20 GLP: yes unpublished

1994c IIA, 5.2.5 Glyphosate Premix: Acute Eye Irritation BAY/ CHE * Test in the Rabbit F`ae`゘cgd Tz・Ipftくc:?J. `pHcö, UK Report No.: 545/41 Date: 1994-07-20 GLP: yes unpublished

1994 IIA, 5.2.6 Glyphosate Premix: Magnusson & Kligman BAY/ CHE d* Maximisation Study in the Guinea Pig ?ョ e`Fä`u゘ Z?d)?/:$ü`aJ Tu./ äf§6O, UK Project No.: 545/42 Date: 1994-07-07 GLP: yes unpublished

1987 IIA, 5.2.3 Acute toxicity of Rodeo herbicide BAY/ CHE * administered by inhalation to male and female Sprague-Daywley rats 8g_みくJzl Tpく, しc/zl$ e95ä.TIju-n Pl, gJ.Tョ/ USA Project No.: EHL 86105, Report No.:-ML- 86-281 Date: 1987-03-18 GLP: yes unpublished

Page 37 of 192

- 38 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1989 IIA, 5.3.2 Glyphosate technical: 90 day oral toxicity Barclay * study in the rat. Cl3:7くatz: Zz6゜(z:7(lzJ. Rcjiく/?. Ireland Report No.: BY-891002 Date: 1989 GLP: yes (without certificate) unpublished 1979 IIA, 5.8 90-day subacute rat toxicity study BAY M-644184-01-2 * (`ett゜:?9j3öe ゕcääJIe4 ・vä Nz9ョa6/cxi龾 B§üf, れta・e.t5o USA Report No.: IRD-78-174 Date: 1979 GLP: no (pre-GLP) unpublished 1995 IIA, 5.4.1 Study of the ability of the test article I.pi.Ci. * glyphosate to induce gene mutations in strains of Salmonella typhimurium. ・Jdrltig: :* Ct`üeäe? :1぀äe4ゕくlä, Italy Exp-No.: 940724 Date: 1995 GLP: yes unpublished

1991 IIA, 5.3.4 Glyphosate 52 Week Oral Toxicity Study in BAY/ CHE * Dogs !B( Report No.: 7502 Date: 1991 GLP: yes unpublished

1989 IIA, 5.3.1 Glyphosate Oral Maximum Tolerated Dose CHE * Study in Dogs -ä`J*8z1 zxBcJäc! ・-//゛e!läv?xj Tlq,. Füzョeli$. UK Report No.: 5660; Project No.: 640683 Date: 1989-03-14 GLP: yes unpublished 1992 IIA, 5.8. AMPA: Teratogenicity Study in Rats -§aäJ CHE * ョ-$ J?*-äe)ä `zil:yjc(6yxz, Scotland Report No.: 7891 Date: 1992 GLP: yes unpublished

1993 IIA, 5.3.7 Glyphosate 3 Week Toxicity Study in Rats CHE * with Dermal Administration x1?Jvfc! BäJe-ä9ä 6:゜ke/(jc(゛c: Eü:., Scotland Report no.: 7839 Date: 1993 GLP: no unpublished

1993 IIA, 5.8. AMPA 4 Week Dose Range Finding Study in CHE * Rats with Administration By Gavage nä``bcJn CJäcä(zp )pa(゜:5ejc:8t :öT., Scotland Report No.: 7803 Date: 1993 GLP: yes unpublished

Page 38 of 192

- 39 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1991 IIA, 5.8 A developmental toxicity study of AMPA in BAY M-645464-01-2 * rats WEf BzJä`x?? くk`?icJEc3(t. -ä.8, G7ü/. USA Report No.: WIL-50159 Date: 1991 GLP: yes unpublished 1988 IIA, 5.1.1 The metabolism of glyphosate in Sprague- BAY M-645024-01-2 * Dawley rats. Part II. Identification, characterization, and quantification of glyphosate ands its metabolites after intravenous and oral administration u*ä/hヸJk tIT? Pj?zva? CaJä-pcz゜ i.ゕ?uc) !`:.BxäJ/ä:c2 JJ゛.ねj7`j USA Report No.: MSL-7206 Date: 1988-02 GLP: no (pre-GLP) unpublished

1991a IIA, 5.4.1 Mutagenicity Test: Ames Salmonella Assay CHE * with Glyphosate, Batch 206-JaK-25-1 ゛j0oPzä QlP, Denmark Lab-No.: 12323 Date: 1991 GLP: yes unpublished

1991 IIA, 5.4.3 Mutagenicity Test: In Vitro Mammalian Cell CHE b* Gene Mutation Test with Glyphosate, Batch 206-JaK-25-1 zä6Po/* P.ヌj Denmark Lab-No.: 12325 Date: 1991 GLP: yes unpublished 1991c IIA, 5.4.4 Mutagenicity Test: Micronucleus Test With CHE * Glyphosate, Batch 206-JaK-25-1 Fa?9/゜_ UjF. Denmark Lab-No.: 12324 Date: 1991 GLP: yes unpublished

1993a IIA, 5.8. Mutagenicity Test: Ames Salmonella Test CHE * with AMPA Pzä゜1i*, Denmark Lab-No.: 13269 Date:1993 GLP: yes unpublished

1991 IIA, 5.8. Mutagenicity Test: Micronucleus Test With CHE d* AMPA a゜Pcyi_, Denmark Lab-No.: 13268 Date:1993 GLP: yes unpublished

Page 39 of 192

- 40 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1983 IIA, 5.5.3 A chronic feeding study of glyphosate BAY M-646425-01-2 * (Roundup@technical) in mice /bqz゘:aJゕt_ョ !ョe., ZäJj /8.れt/J/hc ON? Jc.s?-§ USA Report No.: BDN-77-420 Date: 1983- GLP: no (pre-GLP) unpublished

1996 IIA, 5.2.5 Primary Eye Irritation Study in Rabbits CHE * 龼ä2ダP::/jcü. -0.e, ZäävJ. USA Lab.-No.: 2981-96; Report No.: 390-GLY Date: 1996-09-12 GLP: yes unpublished 1995 IIA, 5.1.1 Metabolism study of 14C-labelled glyphosate FSG * after single oral and intravenous administration to Sprague-Dawley rats TFE Zc5`i2q?-0 Ix I龿?iS9ze*くöo §eo 4$teiy.Zöxv 龽dfVc3ö. Germany Report No.: 9202/95 Date:1995 GLP: yes unpublished

1983 IIA, 5.4.3 CHO/HGPRT gene mutation assay with BAY M-648686-01-2 * glyphosate. れ8Jebju§ Z5`゗cxj4jkgej ejjKcu e`:g)0T2hä. iP, E7・.lJ U.S.A. Study no. ML-83-155 Project No.: 830079. GLP: yes unpublished 1983 IIA, 5.4.4 In vivo bone marrow cytogenetics study of BAY M-645019-01-2 * glyphosate in Sprague-Dawley rats 2j6ね3bJc Lく/q龾adä/vIuj /:D?c2 ä・I・(*Z ゜ä:. P,i 3JTくj, U.S.A. Report No.: EHL study 830083 Project no. ML-83-236. Date: 1983 GLP: no (pre-GLP) unpublished 1989 IIA, 5.2.3 Glyphosate Technical: Acute Inhalation CHE * Toxicity Study in Rats (Limit Test) f30üä-?J ゕJe8?z!? ョ1tj(/?`zj10c, Scotland Report No.: 5993 Date: 1989-08-25 GLP: unpublished

1994 IIA, 5.2.2 Acute dermal toxicity of glyphosate SIN * technical in the rat 4zv-pfcJ ä?uBcJ-z -ji:゜3e.゜a`8e: Eeo2/(ä, Scotland Report No.: T1586.3.A Date: 1994-03-07 GLP: yes unpublished

Page 40 of 192

- 41 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1989 IIA, 5.3.2 Glyphosate 13 Week Dietary Toxicity Study in CHE * Rats 1-J-§zzn aJcCz-äx fi-3?/lvadöäj .Z/7, Fp゛§.?:je UK Report No.: 7136 Date: 1989 GLP: yes Unpublished

1991 IIA, 5.3.2 Glyphosate 13 Week Dietary Toxicity Study in CHE * Mice u2fc§räJ Caä`Jäa3 0aョ4t!j(eit§e l.Tq, ?yt.Piäq6 UK IRI Report No.: 7024 Date: 1991 GLP: Yes unpublished 1993 IIA, 5.2.6 Skin sensitization test in guinea pigs with Luxan * glyphosate technical 955 MIN OF Excel 0$0!zfJ/jJ iZョ, )/$c4Jl/j 9r lz0ivE84qv. qocS, India Project No.: 1230 Date: 1993-05-28 GLP: yes unpublished

1992a IIA, 5.1.1 (14C)-Glyphosate: Absorption, Distribution, CHE * Metabolism and Excretion in the Rat e/xüしec/ .イU (9?ダ?!8:?, England Report No.: 7006-676/2 Date:1992 GLP: no unpublished 1992 IIA, 5.1.1 (14C)-Glyphosate: Absorption and CHE b* Distribution in the Rat – preliminary study e:Üczl_k wG. Qzk!)7?jä, England Report No.: 6365-676/1 Date:1992 GLP: no unpublished

1987 IIA, 5.2.1 Acute oral LD50 study of MON 8750 in BAY/ CHE * Sprague-Dawley rats. P4dg 龼イöI0 ä?a2ゕJaf öpzpfJ.Tzfllz !a9., USA Report No.: FD-86-431 Date: 1987-01-30 GLP: no (pre-GLP) unpublished

1988 IIA, 5.2.2 Acute Dermal Toxicity of Glyphosate in BAY M-644065-01-2 * New Zealand White Rabbits $q5S zxö しIg5 zäpCJ?c( Tc7pnäJfziIt, USA み・Jzö8_: report FD-88-29 Date: 1988-06-08 GLP: yes unpublished

Page 41 of 192

- 42 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1983 IIA, 5.3.3 Six month study of MON 0139 administered by BAY/ CHE * gelatine capsule to beagle dogs れ**§゛Jäl vuZ, D/:xzä ,.Zed i,P öEョ:J. USA ヌTT study No.: 810166, Project No.: ML- 91-368 Date: 1983 GLP: no (pre-GLP) unpublished 1985 IIA, 5.3.4 Twelve-month Study of Glyphosate BAY M-644073-01-2 * administered by Gelatin Capsule to Beagle Dogs $Jgjねv?x k,Zü Qä:6at ゜.Zc, iF, T/Jく3, USA れ*゛Jebvl report: ML-83-137 Date: 1985 GLP: no (pre-GLP) unpublished 1988 IIA, 5.1.1 The metabolism of glyphosate in Sprague BAY M-646124-01-2 * Dawley rats - Part I. Excretion and tissue distribution of glyphosate and its metabolites following intravenous and oral administration. ヸhJ8jqh? :゗0äLョョ)§vzlj t:Öaä$ Thfecd:8`o. ,P: p6tTJ. USA Report No.: MSL-7215,1986 Date: 1988-03-23 GLP: no (pre-GLP) unpublished 1994 IIA, 5.4.3 DNA repair test with primary rat FSG * hepatocytes イWÄQダ ?z3ヸb$0 AX. zF/dc87, Germany Report No.: 931564 Date: 1994 GLP: yes unpublished 1995a IIA, 5.2.1 Final report for oral and dermal LD50 tests SLE * with Sanachem glyphosate acid technical in rats, limit test ?゜Cjhö !?äJ?(?g oIfS: Eg,: )$(/zjSzlCFQ Report No.:00917 Date: 1995-08-08 GLP: no unpublished

1995 IIA, 5.2.1 Oral and dermal LD50 tests with Sanachem Sana- chem b* glyphosate 62% IPA in rats, limit test :゛C?n0 BcJcä)e゜ )Sh:r .T/3, llzS(c*!. ゕF ダ Report No.: 00917 Date: 1995-08-08 GLP: yes unpublished 1995a IIA, 5.2.2 Final report for oral and dermal LD50 tests SLE * with Sanachem glyphosate acid technical in rats, limit test tüa0R* cJ-ce!eu ISl4` く,Ti SciIeiゕ)djFO Report No.:00917 Date: 1995-08-08 GLP: no unpublished

Page 42 of 192

- 43 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1995 IIA, 5.2.2 Oral and dermal LD50 tests with Sanachem Sana- chem b* glyphosate 62% IPA in rats, limit test C1lä゛3 J?(zBäzu S/く!r /g,E. F゜l(?i(?. Pゕ w Report No.: 00926 Date: 1995-08-08 GLP: No unpublished

1994 IIA, 5.2.1 Glyphosate: Acute oral toxicity (limit test) Herbex * in the rat ?ä・IP-ョ?龿 ä9äIjJT7fldä 1Zi,. Ö.z-3q UK Report No.: 710/14 Date: 1994-10-17 GLP: yes unpublished

1978 IIA, 5.4.1 Microbial mutagenicity testing on CP 67573 BAY M-645021-01-2 * (glyphosate) (lvlc$Jil 5( Z*I・g゘z_txljä Lö:?ybgjb*, Japan Report No.: ET 78-241. Date: 1978 GLP: no (pre-GLP) unpublished 1994a IIA, 5.2.2 Glyphosate: Acute dermal toxicity (limit Herbex * test) in the rat Pzrä゛6cf぀ Tgg8-tJ.e!?lc ä(pョw , UK Report No.: 710/15 Date: 1994-10-17 GLP: yes Unpublished

1994 IIA, 5.2.4 Glyphosate 360 g/L: Acute dermal irritation Herbex b* test in the rabbit P?!n龾aü?f Z?h゜`c/i゜-äJ iyZ. a25ロI, UK FFZ Project No.: 710/29 Date: 1994-10-18 GLP: yes unpublished

1994c IIA, 5.2.5 Glyphosate: Acute eye irritation test in the Herbex * rabbit (?äf龿Fäu゜ 1)jdtäTe$e)J iE゜. ?Y)81, UK Project No.: 710/18 Date: 1994-10-18 GLP: yes Unpublished

1994 IIA, 5.2.6 Glyphosate: Magnusson & Kligman Herbex d* maximisation study in the guinea pig Pä!ag0゗e) ?_/)JE4`?q:a. A?§)゜, UK FFZ Project No.: 710/19 Date: 1994-10-24 GLP: yes unpublished

Page 43 of 192

- 44 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1987 IIA, 5.3.2 90-Day Study of Glyphosate Administered in BAY M-644074-01-2 * Feed to Sprague-Dawley Rats みk3cj・J7 Uväz/l Z§(z.zく*f?i/J F:, Zく.njJ ねJ7fjjJ1. USA Study No.: 68128; ねöJ:xz87 report: ML-86-351 Date: 1987 GLP: No (pre-GLP) unpublished

1993 IIA, 5.8. AMPA: 13 Week Toxicity Study in Rats CHE * with Administration By Gavage く0J1(?-c BaJ?ä8`? lqcj:81ztfくzf ,Ely. Scotland Report No.: 7866 Date: 1993 GLP: yes unpublished 1991f IIA, 5.3.1 28 day dietary study in Wistar rats – test FSG * compound: Glyphosate technical (FCS 03090 H/05 March 1990) /Bz/lJ f*t゛e l8.E Re$cv(zく/, India Report No.: ES.881.28.DDR Date: 1991-01 GLP: yes unpublished

1994 IIA, 5.4.4 Genetic toxicology - in vivo mammalian FSG * bone marrow cytogenetic test - Chromosomal analysis Report No.: 890-MUT-CH.AB Date: 1994 GLP: yes unpublished

1993c IIA, 5.4.4 Mutagenicity - Micronucleus test in swiss FSG * albino mice ä/lJBt Q(ä3??:_x龼j? Cc(kJ?ca Fijül?u. zk?2`C゛t?. India Study No.: TOXI: 889-MUT.MN Report No.: 889-MUT-MN Date: 1993 GLP: yes unpublished 1991a IIA, 5.2.1 Acute oral toxicity with glyphosate technical FSG * /jゕ?/J O86゗tei*-?ca CJ?(z?cv P/53.z/j 5e:9)Czn?, India Report No.: TOXI:ES.874.AOR Date: 1991-04-13 GLP: yes unpublished

1991 IIA, 5.2.1 Acute oral toxicity study in swiss albino FSG b* mice tゕe:iJ 5)hauaa/H゘tz C?cäeJ!5 F_.jzi/v g*ä`Räj3z, India Report No.: ES.875.AOM Date: 1991 GLP: yes Unpublished

Page 44 of 192

- 45 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1991c IIA, 5.2.2 Acute dermal toxicity study with glyphosate FSG * technical in Wistar rats ?/j/BJ wel?iof2ö?゗ä ze(?üゕäJ Fiäj9üt. Cy:3Ize*?, India Study No.: ES.876.ADR Date: 1991-04-13 GLP: yes unpublished

1991 IIA, 5.2.4 Primary skin irritation study in New Zealand FSG d* white rabbits BilJz/ ヌくb?龾?h`zlät J?`ゕazzk äj:.F/xx CekpIä/ü?, India Report No.: ES.878.SKIN Date: 1991-04-13 GLP: yes unpublished

1991e IIA, 5.2.5 Primary eye irritation study in rabbits FSG * :C?itJ 3yaa/eiO!n龼c ゕJääcIz8 Fä::ョ.ix ゕbä6z/2(c, India Report No.: ES.879.EYE Date: 1991-04-13 GLP: yes unpublished

1992 IIA, 5.3.2 90 day oral toxicity study in Wistar rats - FSG * test compound: Glyphosate technical (FCS 03090 H/05 March 1990) tjJCzj -x:zö Zj.ö C0oj゛c??-, India Report No.: ES.882.90.OR Date: 1992-04-10 GLP: yes unpublished 1992 IIA, 5.4.6 Dominant Lethal test in Wistar Rats FSG * Ce/iJl l:じdIn?1a龼ze ゕäJäz`ek Plc:ju.h ゕä9c3z.6i! India Study No.: TOXI: 888-DLT Date: 1992 GLP: yes unpublished

1991 IIA, 5.6.10 Teratogenicity study in Wistar rats FSG g* Ce://J 5zä/iÄ!d゜゗e? ?czfe_BJ F:jhv/c. z:Rc227-z, India Report No.: ES.883.TER-R Date: 1991- GLP: yes unpublished

1980 IIA, 5.6.10 Teratology study in rats BAY M-644179-02-2 * ))bäjjqülz8c: aJääoB)ä ve゛ ?d?tyqä/cjロ龼く y*.B), ヸ:jcc.äA゛ね:a3l6?2 US Report No.: IR-79-016 Date: 1980 GLP: no (pre-GLP study) unpublished

Page 45 of 192

- 46 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1989 IIA, 5.2.3 4-hour, acute inhalation toxicity study with IPC * glyphosate technical in rats BCゕ Switzerland ゕゕC Project No.: 238105; Report No.: PRO426 Date: 1989-07-17 GLP: yes unpublished 1995 IIA, 5.4.1 Glyphosate Reverse mutation assay “Ames Herbex * Test” using Salmonella typhimurium P8c龼ä)ab! Zc/x!Jz5_(jz Ej,1. zI$5X, UK Project No.: 710/20 Date: 1995 GLP: yes unpublished

1994c IIA, 5.2.2 Acute dermal toxicity in rats Jt//c- ALK * §i゜ (n §jzv5Z5_i3, Hungary Report No.: GHA-94-402/R Date: 1994-04-06 GLP: yes unpublished 1994 IIA, 5.2.3 Acute inhalation toxicity in rats ALK d* ($/jlJi* `k Lx?v7lp:ö§, Hungary Study No.: G36-94-403/R Date: 1994-04-06 GLP: yes unpublished

1994 IIA, 5.2.5 Primary eye irritation study in New Zealand ALK white rabbits -yjqzJ/j/ y- ゛teü:5yEpd, Hungary Report No.: GHA-93-405/N Date: 1994-04-11 GLP: yes unpublished

1991 IIA, 5.8 90-Day oral (capsule) toxicity study in dogs BAY M-645465-01-2 * with AMPA TWr äcIeBäJu Eeく2f_`/aJ.äl (7?., Äol7, USA Report No.: WIL-50173 Date: 1991-07-16 GLP: yes unpublished 1994 IIA, 5.2.1 Acute oral toxicity in rats ALK b* röJ:i*ia: v` dah゜Edjj57. ヌccl2zjJh, Hungary Report No.: GHA-94-401 Date: 1994-04-06 GLP: yes unpublished 1994e IIA, 5.2.4 Primary dermal irritation study in rabbits ALK * ü:arJi/yj v! くpLbü/zöjv, Hungary Report No.: GHA-93-404/N Date: 1994-04-08 GLP: yes unpublished

Page 46 of 192

- 47 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not 1994 IIA, 5.2.1 Glyphosate technical acute oral toxicity I.Pi.Ci * study in mice ゛Jjl:3゜!j /6 -Cläzz9c ゕ:8龾z:zylä3. Ehfvut, Italy Report No.: 940020 Date: 1994-03-18 GLP: yes unpublished 1991a IIA, 5.2.4 Glyphosate tecnico 98% - Acute dermal I.Pi.Ci. * irritation study in rabbits. Acute eye irritation study in rabbits. :t゜-Jjkl 5/ l)ゕaza1a $?lüゕ/゘oä/c, Italy Exp. Nos.: 910259, 910260 Report Nos.: PRO495, PRO496 Date: 1991-10-10 GLP: yes unpublished

1991 IIA, 5.2.5 Acute eye irritation study in New Zealand I.Pi.Ci. b* White rabbits treated with the test article glyphosate technico 98% /j!Jil9゛ 3/ l?zaB)ga 3lCt8龽a?:hc, Italy Report No.: 910260 Date: 1991-10-10 GLP: yes Unpublished 1989a IIA, 5.2.1 Acute oral toxicity study with glyphosate I.Pi.Ci * technical (isopropylamine salt 62% in water IPC equivalent to 46% of N-phosphonomethylglycine acid) in rats ゕBB Switzerlan BBB Project No.: 238050; Report no.: PRO439 Date: 1989-06-20 GLP: yes unpublished

1989 IIA, 5.2.5 Primary eye irritation with glyphosate technical I.Pi.Ci. d* (isopropylamine Salt 62% in water equivalent to 46% of N- phosphomonomethylglycine acid) in the rabbit (rinsed / unrinsed eyes). BBR Project No.: 238083, Report No.: PRO423 Date: 1989-08-24 GLP: yes unpublished

1989 IIA, 5.2.2 Acute dermal toxicity study with glyphosate I.Pi.Ci b* technical (isopropylamione salt 62% in water equivalent to 46% of N- phosphonomethylglycine acid) in rats BBR Switzerland CBゕ Project No.: 238061, Report No.: PRO425 Date: 1989-06-20 GLP: yes unpublished

Page 47 of 192

- 48 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1989c IIA, 5.2.4 Primary skin irritation study with glyphosate I.Pi.Ci * technical (isopropylamione salt 62% in water equivalent to 46% of N- phosphonomethylglycine acid) in rabbits (4- hour semi-occlussive application on intact and abraded skin ゕゕR Project No.: 238072, Report No.: PRO438 Date: 1989-08-24 GLP: yes unpublished 1995 IIA, 5.4.2 Evaluation of the ability of glyfosaat to induce AGC/ BAY * chromosome aberrations in cultured peripheral human lymphocytes (with independent repeat) ÄEDHO ,,RÄ U6/dö Project 141918 Date: 1995 GLP: yes unpublished

1992a IIA, 5.2.1 Glyphosate technical: Acute oral toxicity Barclay * (limit test) in the rat Pcc4・)ä)゗ e2ä:l?Eq-・`J .Tj8, ヌc3I2, UK Report No.: 134/37 Date: 1992-02-07 GLP: yes unpublished 1992 IIA, 5.2.2 Glyphosate technical: Acute dermal toxicity Barclay b* (limit test) in the rat r-P??・g?& 7üe/:äJEä`ü!. zくG`0 , UK Project No.: 134/38 Date: 1992-02-07 GLP: yes Unpublished 1991 IIA, 5.2.6 Luxan Glyphosate techn.: Magnusson & LUX * Kligman maximisation study in the guinea pig Pz-z゛z`぀q 3/laEz4!e*`J. z`くGu, UK Project No.: 349/11, Report no.: TO-218 Date: 1991-02-11 GLP: yes unpublished

1987a IIA, 5.2.1 Acute oral toxicity of 64% SN750721 SIN * technical liquid in mice Eä?lじo ・`le5i:q(Yäj ・zBa぀:ztJ pzo §läEy FhoJüJ/eac ä(CJaä?0 /:i!yJhlä, Taiwan Report No.: TX58AO1 Date: 1987-02-28 GLP: no unpublished 1987 IIA, 5.2.1 Acute oral toxicity of 41% SN750721 SIN b* solution in mice じäEcj1 öeilk`:Üf/ö? Btz8ä゗e:J e$y 2tLnä 06Jö?P/äeJ aJz?Ba-o tj4(8Jjjz. Taiwan Report No.: TX58AO2 Date: 1987-02-28 GLP: no unpublished

Page 48 of 192

- 49 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1983 IIA, 5.4.3 The hepatocyte primary culture/DNA repair BAY M-645649-01-2 * assay on compound JJN-I020 (glyphosate) using rat hepatocytes in culture ゗ct?äD)0 //6G?ä 58äくS・くj:y. イ?v:0) Yc7? くJjc!/jxi `ü- K/Jc?J? ョiöS!ääpt゛. cieizH7t. VaY ゛!し1 4* hc9(ej Iq bJ゜ヸ xzxj Report No.: AH-83-181. Date: 1983 GLP: yes unpublished 1980 IIA, 5.4.6 Dominant Lethal study in mice BAY M-643921-01-2 * (,・i ?JääCcfo zxu A?§ä/ay1&_j ゛BIく , ねäotely1, USA Report No.: IR-79-014 Date: 1980 GLP: no (pre-GLP) unpublished

Page 49 of 192

- 50 - Glyphosate –List of tests and studies Toxicology and metabolism 1.2 Toxicology and metabolism – Representative formulation

Year Annex point/ Title Owner Bayer Document reference Source -Company name Number number Report No. Date GLP status, published or not

1991a IIIA, 7.1.1/01 Acute Oral Toxicity Study In Rats. BAY M-646120-01-2 (B.5.11.1.1) lk?Rj09く゗leJ _z,.) Oü`:龼ölcä? ü! n゛tz/pEdq§. äJL: ヸ/Jxttlhz. Qs, USA Report No.: BD-91-261 Date: 1991-10-18 GLP: yes not published

1991b IIIA, 7.1.2/01 Acute Dermal Toxicity Study In Rats. BAY M-646353-01-2 (B.5.11.1.2) ゕtggくJ:8z龿lä ä,`p. a4z5Öf/龿äi _I Eq/e_:ndく6. JZ?i れjc.:tJ/yx NJ, USA Report No.: BD-91-262 Date: 1991-10-18 GLP: yes not published 1992b IIIA 7.1.6 MON 52276: Closed-Patch repeated BAY M-644178-01-2 * (B.5.11.1.6) insult dermal sensitization study in guinea pigs (Buehler method). lt9clRxョ゜&äJ *?-,. Üs. USA Report No.: BD-91- 264 Date: 1991-10-10 GLP: yes not published 1999 IIIA, 7.1.3/01 Measurements of granulometry BAY M-651455-01-2 (B.5.11.1.3) and distribution of a spray nozzle – Comparison of different glyphosate formulations ä-).R぀ä$c :ctaねyvg/:-, France Report 106/Pulv Date: GLP: no unpublished 1991c IIIA, 7.1.4/01 Primary dermal irritation study in rabbits. BAY M-646352-01-2 (B.5.11.1.4) Bio/dynamics Inc., Department of Egkiqhta4ョ. äJ/Z tJ7aね:jiq. sロ, USA Report No.: BD-91-263 Date: 1991-10-18 GLP: yes not published

1992a IIIA, 7.1.5/01 Primary eye irritation study in rabbits. BAY M-646351-01-2 (B.5.11.1.5) Bio/dynamics Inc., Department of E:i7.öüz3゜ö ZäJl れJ:üä:/:u. sロ, USA Report No.: BD-91-60 Date: 1991-09-24, amended 1992-02-05 GLP: yes not published 2001 IIIA, 7.1.6/01 Skin sensitization test in guinea pigs BAY M-646462-01-2 (Modified Buehler test: 9 applications). )RZ. CF $90. n゜4uo (u.Zycd France Report No.: CI-2001-153 Date: 2001-10-25 GLP: yes not published

Page 50 of 192

- 51 - Glyphosate –List of tests and studies Toxicology and metabolism Year Annex point/ Title Owner Bayer Document reference Source -Company name Number number Report No. Date GLP status, published or not

2010 IIIA, 7.6.2/01 360 g/L Glyphosate SL Formulation BAY M-645648-01-2 (MON 52276) – In vitro absorption of Glyphosate through human epidermis a(?iÜ龽 Lcg3_z6*tk く゜if_Zcfe4 ,Zjn. み ?3 rR§. Ütäa? Y*z`j//_Ju jozFecz ?k゜ゕ y3JJ/zJ vFe(. czY/ä. ä-_!aF:!pJ9:f. PZ9 dÄT. UK Report No.: JV2084- REG Date: 2010-02- 19 GLP: yes not published

Page 51 of 192

- 52 - Glyphosate –List of tests and studies Toxicology and metabolism

1.3 List of all Other/Special Studies in Section IIA 5.10

A list of all Other/Special Studies in Section IIA 5.10 is presented in three tables in the following pages:

• Table 1 lists other relevant studies conducted by the Glyphosate Task Force or member companies in support of the submission, that do not fit within any other dossier points . • Table 2 lists all the relevant peer-reviewed publications from the literature that were selected for inclusion in the submission. For each publication it is noted whether or not a Klimisch rating (Klimisch, 1997) is included in the review. • Table 3 lists the publications and other documents that are cited within the discussion of the literature. These include documents such as government or company reports; publications that are included in the literature review under another section of the dossier; and publications that are outside the scope of the literature review.

Table 1. Studies conducted by the Glyphosate Task Force or member companies in support of the submission

Annex Year Title Owner Bayer Document point/ Source (where different from company), Number reference Company name number Report No. Date GLP status (where relevant) published or not

IIA, 5.10 1996 Glyphosate Acid: Comparison of Salivary SYN Gland Effects in Three Strains of Rat. ゕai(§?t ゛äö:g・pEq: öel*fTä9!6. /8ccU-to c`F§ z:z`/nみaaJjä. RqcJ$l!z UK Data owner: F・jökä9ä Study No.: CTL/P/5160 Date: 1996-08-19 GLP: yes unpublis hed IIA, 5.10 2010 An 8-Week Oral (Diet and Gavage) Toxicity GTF Study of Citric Acid in Male Rats W-E BJz5ce)a ゛c:p)JE?n!tä. ZZR. J?hQuj ョ. /6Xü. US Data owner: 34:じLPヸ 7Jeiv Study No.: WIL- 50361 Date: 2010-01-08 GLP: yes

Page 52 of 192

- 53 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Year Title Owner Bayer Document point/ Source (where different from company), Number reference Company name number Report No. Date GLP status (where relevant) published or not

IIA, 5.10 2012 Glyphosate – A 28-Day Oral (Dietary) GTF Immunotoxicity Study in Female B6C3F1 Mice -TW ゕzJzfceu E1c/1tä・!-cJ. Tゕ.Z J/pョ.Y゜ä ヌY p*q29・brhく龿0E・üよ)龼h゛. ),8a. Ä4t!lxtc Cbl Z7・t゜v?a$n J)ゕ?ce?0 ?F!2. x0h8.ゕ:?龿 Qじ oョ2bョ, USA Project No.: WI-10-460 (Study No.: WIL- 50393) Data owner: ヸn_J?$lx Date: 2012-03-21 GLP: yes not published IIA, 5.10 1996 Glyphosate Technical: Pharmacology Screening NUF Study in the Rat -c゛nc゘P?f T4?:く-jäz_)J n,.Zi )nOa0, UK Data owner: Nufarm Study No.: 434/021 Date: 1996-06-28 GLP: yes unpublis hed

Table 2. Relevant glyphosate literature Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Abass K, Lamsa V, 2012 Characterization of human cytochrome P450 1 Reponen P, Kublbeck induction by pesticides. Toxicology 294 (1):17-26 J, Honkakoski P, Matti- la S, Pelkonen O, Hak- kola J

IIA 5.10 Abass K, Turpeinen M, 2009 An evaluation of the cytochrome P450 inhibition 1 Pelkonen O potential of selected pesticides in human hepatic microsomes. Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes 44 (6):553 - 563. DOI: 10.1080/03601230902997766.

IIA 5.10 Acquavella J, Doe J, 2003 Epidemiologic studies of occupational pesticide 1 Tomenson J, Chester G, exposure and cancer: Regulatory risk assessments and Cowell J, Bloemen L biologic plausibility. Annals of Epidemiology 13 (1):1-7

IIA 5.10 Acquavella JF, Alexander 2006 Exposure misclassification in studies of 1 BH, Mandel JS, Burns CJ, agricultural pesticides: insights from Gustin C biomonitoring. Epidemiology 17 (1):69-74 IIA 5.10 Acquavella JF, Ale- xander 2006 The Farm Family Exposure Study: Acquavella et al. 1 BH, Mandel JS, Gustin C Respond. Environ Health Perspect 114 (11):A633- A634. DOI: 10.1289/ehp.114- a633b.

Page 53 of 192

- 54 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Acquavella JF, Alexander 2004 Glyphosate biomonitoring for farmers and their 1 E K BH, Mandel JS, Gustin C, families: Results from the farm family Baker B, Chapman P, exposure study. Environmental Health Per- Bleeke M spectives 112 (3):321-326. Doi 10.1289/Ehp.6667.

IIA 5.10 Acquavella JF, Cowell JE, 2001 Implications of Glyphosate Toxicology and Human 1 Cullen MR, Farmer DR, Biomonitoring Data for Epidemiologic Research. Pastides H Journal of Agromedicine 7 (4):7 - 27 IIA 5.10 Acquavella JF, Gustin C, 2005 Implications for epidemiologic research on variation 1 Alexander BH, Mandel JS by pesticide in studies of farmers and their families. Scandinavian Journal of Work Environment & Health 31:105-109

IIA 5.10 Adams RD, Gibson 2010 Systematic differences between healthcare 1 AL, Good AM, professionals and poison information staff in the Bateman DN severity scoring of pesticide exposures. Clin Toxicol (Phila) 48 (6):550-8. DOI: 10.3109/15563650.2010.491484.

IIA 5.10 Aggrawal A 2006 Agrochemical Poisoning. In Forensic Pathology 1 Reviews, edited by M. Tsokos. Chapter 10. pp 261- 327. DOI: 10.1007/978-1- 59259-921-9_10.

IIA 5.10 Akcha F, Spagnol C, 2012 Genotoxicity of diuron and glyphosate in oyster 1 Also Rouxel J spermatozoa and embryos. Aquatic toxicology listed (Amsterdam, Netherlands) 106- under IIA 107:104-13. 8.16 doi:10.1016/j.aquatox.2011.10.018.

IIA 5.10 Alarcon WA, Calvert GM, 2005 Acute illnesses associated with pesticide exposure 1 Blondell JM, Mehler LN, at schools. JAMA 294 (4):455-65. DOI: Sievert J, Propeck M, 10.1001/jama.294.4.455. Tibbetts DS, Becker A, Lacko- vic M, Soileau SB, Das R, Beckman J, Male DP, Thomsen CL, Stanbury M

IIA 5.10 Alavanja MC, Samanic C, 2003 Use of agricultural pesticides and prostate cancer 1 Dosemeci M, Lubin J, risk in the Agricultural Health Study cohort. Am J Tarone R, Lynch CF, Knott Epidemiol 157 (9):800-14 C, Thomas K, Hoppin JA, Barker J, Coble J, Sandler DP, Blair A

IIA 5.10 Alexander D, Weed D, 2011 A weight-of-evidence review of colorectal cancer in 1 Mink P, Mitchell M pesticide applicators: the agricultural health study and other epidemiologic studies. International Archives of Occupational and Environmental Health:1-31. DOI: 10.1007/s00420-011-0723-7.

IIA 5.10 Alvarez-Moya C, Silva 2011 Evaluation of genetic damage induced by glyphosate 3 (8.16) K Also MR, Arambula ARV, isopropylamine salt using Tradescantia bioassays. 2 (5.10) listed Sandoval AI, Vasquez HC, Genetics and Molecu- lar Biology 34 (1):127-130 under IIA Montes RMG 8.16

Page 54 of 192

- 55 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Amer SM, Aly FAE, 2006 In vitro and in vivo evaluation of the genotoxicity of 2 Farghaly AA, A.A.E. I the herbicide glyphosate in mice. Bulletin of the National Research Centre (Egypt) 31 (5):427-446

IIA 5.10 Amerio P, Motta A, Toto 2004 Skin toxicity from glyphosate-surfactant 1 P, Pour SM, Pajand R, formulation. Journal of Toxicology-Clinical Feliciani C, Tulli A Toxicology 42 (3):317-319. Doi 10.1081/Clt- 120038769.

IIA 5.10 Anadon A, Martinez- 2009 Toxicokinetics of glyphosate and its metabolite 1 E K Larranaga MR, Martinez aminomethyl phosphonic acid in rats. Toxicol Lett 190 MA, Castellano VJ, (1):91-5. DOI: Martinez M, Martin MT, 10.1016/j.toxlet.2009.07.008. Nozal MJ, Bernal JL

IIA 5.10 Andre V, Goff JL, 2007 Evaluation of bulky DNA adduct levels after 1 Pottier D, Lebailly P, pesticide use: Comparison between open-field Peluso M, Munnia A, farmers and fruit growers. Toxicological & Gauduchon P Environmental Chemistry 89 (1):125 - 139

IIA 5.10 Andreotti G, Freeman 2009 Agricultural pesticide use and pancreatic cancer 1 LEB, Hou L, Coble J, risk in the Agricultural Health Study Cohort. Rusiecki J, Hoppin JA, International Journal of Cancer 124 (10):2495- Silverman DT, Alavan- ja 2500 MCR

IIA 5.10 Arbuckle TE, Lin ZQ, 2001 An exploratory analysis of the effect of pesticide 3 E K Mery LS exposure on the risk of spontaneous abortion in an Ontario farm population. Envi- ronmental Health Perspectives 109 (8):851-857

IIA 5.10 Aris A 2012 Response to comments from Monsanto scientists 1 on our study showing detection of glyphosate and Cry1Ab in blood of women with and without pregnancy. Reproductive Toxicology 33 (1):122- 123. doi: 10.1016/j.reprotox.2011.10.008.

IIA 5.10 Aris A, Leblanc S 2011 Maternal and fetal exposure to pesticides associated to 1 E K genetically modified foods in Eastern Townships of Quebec, Canada. Repro- ductive Toxicology 31 (4):528-533. doi: 10.1016/j.reprotox.2011.02.004.

IIA 5.10 Asita AO, Makhaleme- le 2008 Genotoxicity of Chlorpyrifos, Alpha-thrin, Efekto 1 R virikop and Springbok to onion root tip cells. African Journal of Biotechnology 7 (23):4244-4250

IIA 5.10 Astiz M, de Alaniz MJ, 2009 Effect of pesticides on cell survival in liver and brain 1 E K Marra CA rat tissues. Ecotoxicol Environ Saf 72 (7):2025-32. DOI: 10.1016/j.ecoenv.2009.05.001.

IIA 5.10 Astiz M, de Alaniz 2009 Antioxidant defense system in rats simultaneously 1 MJT, Marra CA intoxicated with agrochemicals. Environmental Toxicology and Pharmacology 28 (3):465-473. DOI: 10.1016/j.etap.2009.07.009.

Page 55 of 192

- 56 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Astiz M, de Alaniz 2009 The impact of simultaneous intoxication with 1 MJT, Marra CA agrochemicals on the antioxidant defense system in rat. Pesticide Biochemistry and Phy- siology 94 (2- 3):93-99. DOI: 10.1016/j.pestbp.2009.03.005.

IIA 5.10 Astiz M, Zirulnik F, 2009 Overview of glyphosate toxicity and its commercial 1 Gimenez MS, de Ala- niz formulations evaluated in laboratory animal tests. MJT, Marra CA Current Topics in To- xicology 6:1-15

IIA 5.10 Axelrad JC, Howard 2003 The effects of acute pesticide exposure on 3 E K CV, McLean WG neuroblastoma cells chronically exposed to diazinon. Toxicology 185 (1-2):67-78 IIA 5.10 Baker BA, Alexander BH, 2005 Farm Family Exposure Study: methods and 1 Mandel JS, Acquavella JF, recruitment practices for a biomonitoring study of Richard HE, Chapman P pesticide exposure. Journal of Exposure Analysis and Environmental Epidemiology 15 (6):491-499. DOI 10.1038/sj.jea.7500427.

IIA 5.10 Band PR, Abanto Z, Bert J, 2011 Prostate Cancer Risk and Exposure to 1 Lang B, Fang R, Gallagher Pesticides in British Columbia Farmers. Prosta- te 71 RP, Le ND (2):168-183. doi: 10.1002/pros.21232. IIA 5.10 Bando H, Murao Y, Aoyagi 2010 [Extreme hyperkalemia in a patient with a new 1 T U, Hirakawa A, Iwase M, glyphosate potassium herbicide poisoning: report of a Nakatani T case]. Chudoku Kenkyu 23 (3):246- 249

IIA 5.10 Barbosa ER, da Costa 2001 Parkinsonism after glycine-derivate exposure. 2 E K MDL, Bacheschi LA, Movement Disorders 16 (3):565-568 Scaff M, Leite CC IIA 5.10 Bell EM, Hertz- Picciotto 2001 Case-Cohort Analysis of Agricultural Pesticide 1 I, Beaumont JJ Applications near Maternal Residence and Selected Causes of Fetal Death. American Journal of Epidemiology 154 (8):702-710. doi: 10.1093/aje/154.8.702.

IIA 5.10 Bell EM, Hertz- Picciotto 2001 A case-control study of pesticides and fetal death 3 K I, Beaumont JJ due to congenital anomalies. Epidemio- logy 12 (2):148-56 IIA 5.10 Belle R, Le Bouffant R, 2007 Sea urchin embryo, DNA-damaged cell cycle 3 E K Morales J, Cosson B, checkpoint and the mechanisms initiating cancer Cormier P, Mulner- development. J Soc Biol 201 (3):317-27 Lorillon O

IIA 5.10 Benachour N, Seralini 2009 Glyphosate formulations induce apoptosis and 3 E K GE necrosis in human umbilical, embryonic, and placental cells. Chem Res Toxicol 22 (1):97- 105. DOI: 10.1021/tx800218n.

IIA 5.10 Benachour N, Sipahu- tar 2007 Time- and dose-dependent effects of roundup on 3 E K H, Moslerni S, Gas- nier C, human embryonic and placental cells. Ar- chives of Travert C, Sera- lini GE Environmental Contamination and Toxicology 53 (1):126-133. DOI 10.1007/s00244-006-0154-8.

IIA 5.10 Benedetti AL, Vituri 2004 The effects of sub-chronic exposure of Wistar rats to 2 E K CD, Trentin AG, the herbicide Glyphosate-Biocarb (R). Toxicology Domingues MAC, Letters 153 (2):227-232. DOI Alvarez-Silva M 10.1016/j.toxlet.2004.04.008.

Page 56 of 192

- 57 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Benítez-leite S, Macchi 2009 Malformaciones congénitas asociadas a agrotóxicos. E K ML, Acosta M Archives of Pediatrics 80 (3):377- 378. doi: 10.4067/S0370- 41062009000400010.

IIA 5.10 Beuret CJ, Zirulnik F, 2005 Effect of the herbicide glyphosate on liver 1 Gimenez MS lipoperoxidation in pregnant rats and their fetuses. Reproductive Toxicology 19 (4):501- 504. DOI 10.1016/j.reportox.2004.09.009.

IIA 5.10 Blair A, Freeman LB 2009 Epidemiologic Studies in Agricultural 2 Populations: Observations and Future Directions. Journal of Agromedicine 14 (2):125-131. doi: 10.1080/10599240902779436.

IIA 5.10 Bo Nielsen J 2010 Efficacy of skin wash on dermal absorption: an in 1 vitro study on four model compounds of varying solubility. Int Arch Occup Environ Health 83 (6):683- 90. DOI: 10.1007/s00420- 010-0546-y.

IIA 5.10 Bo Nielsen J, Ahm 2009 The usual suspects-influence of physicochemical 1 Sorensen J, Nielsen F properties on lag time, skin deposition, and percutaneous penetration of nine model compounds. J Toxicol Environ Health A 72 (5):315-23. DOI: 10.1080/15287390802529872.

IIA 5.10 Bolognesi C, Bonatti S, 1997 Genotoxic activity of glyphosate and its technical E K Degan P, Gallerani E, formulation roundup. Journal of Agricultural and Peluso M, Rabboni R, Food Chemistry 45 (5):1957- Roggieri P, Abbondandolo 1962. doi: 10.1021/jf9606518. A

IIA 5.10 Bolognesi C, 2009 Biomonitoring of genotoxic risk in agricultural 2 Carrasquilla G, Volpi S, workers from five colombian regions: association to Solomon KR, Marshall occupational exposure to glyphosate. J Toxicol EJ Environ Health A 72 (15-16):986-97. DOI: 10.1080/15287390902929741.

IIA 5.10 Bolognesi C, Creus A, 2011 Micronuclei and pesticide exposure. 2 Ostrosky-Wegman P, Mutagenesis 26 (1):19-26. doi: Marcos R 10.1093/mutage/geq070. IIA 5.10 Bolognesi C, Landini E, 2004 Cytogenetic biomonitoring of a floriculturist 3 K Perrone E, Roggieri P population in Italy: micronucleus analysis by fluorescence in situ hybridization (FISH) with an all- chromosome centromeric probe. Mutation Research- Genetic Toxicology and Environmental Mutagenesis 557 (2):109-117. DOI 10.1016/j.mrgentox.2003.09.013.

IIA 5.10 Bolognesi C, Perrone 2002 Micronucleus monitoring of a floriculturist 3 K E, Landini E population from western Liguria, Italy. Muta- genesis 17 (5):391-397 IIA 5.10 Bonner MR, Alavanja 2005 The Agricultural Health Study Biomarker Workshop 1 MCR on Cancer Etiology - Introduction: Overview of study design, results, and goals of the workshop. Journal of Biochemical and Molecular Toxicology 19 (3):169- 171. Doi 10.1002/Jbt.20070.

Page 57 of 192

- 58 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Bortoli GM, Azevedo 2009 Cytogenetic biomonitoring of Brazilian workers 2 MB, Silva LB exposed to pesticides: micronucleus analysis in buccal epithelial cells of soybean growers. Mutat Res 675 (1-2):1-4. DOI: 10.1016/j.mrgentox.2009.01.001.

IIA 5.10 Bradberry SM, Proudfoot 2004 Glyphosate poisoning. Toxicol Rev 23 (3):159- 1 AT, Vale JA 67 IIA 5.10 Bukowska B, Pieniazek 2002 Hemolysis and Lipid Peroxidation In Human 1 D, Duda W Erythrocytes Incubated With Roundup. Cur- rent Topics in Biophysics 26 (2):245-249 IIA 5.10 Burger M, Fernandez S 2004 Exposición al herbicida glifosato: aspectos 1 clínicos toxicológicos. Revista Medica del Uruguay 20 (202-207) IIA 5.10 Caglar S, Kolankaya D 2008 The effect of sub-acute and sub-chronic exposure of 2 rats to the glyphosate-based herbicide Roundup. Environmental Toxicology and Pharmacology 25 (1):57-62. DOI 10.1016/j.etap.2007.08.011.

IIA 5.10 Caloni F, Cortinovis C, 2012 Animal poisoning in Italy: 10 years of 1 Rivolta M, Davanzo F epidemiological data from the Poison Control Centre of Milan. Veterinary Record. DOI: 10.1136/vr.100210.

IIA 5.10 Calvert GM, Mehler 2003 Acute pesticide-related illnesses among working 1 LN, Rosales R, Baum youths, 1988-1999. American Journal of Public L, Thomsen C, Male D, Health 93 (4):605-610 Shafey O, Das R, La- ckovic M, Arvizu E

IIA 5.10 Carrasco AE 2011 Reply to the Letter to the Editor Regarding Our Article 3 E K (Paganelli et al., 2010). Chemical Re- search in Toxicology 24 (5):610-613. doi: 10.1021/tx200072k.

IIA 5.10 Carreon T, Butler MA, 2005 Gliomas and farm pesticide exposure in women: 1 Ruder AM, Waters MA, The Upper Midwest Health Study. Environmental Davis-King KE, Calvert Health Perspectives 113 (5):546-551. Doi GM, Schulte PA, Connally 10.1289/Ehp.7456. B, Ward EM, Sanderson WT, Heineman EF, Mandel JS, Morton RF, Reding DJ, Rosenman KD, Talaska G, Grp BCCS IIA 5.10 Cavalcante DGSM, 2008 Genotoxic effects of Roundup (R) on the fish 1 (8.16) Also Martinez CBR, Sofia SH Prochilodus lineatus. Mutation Research- Genetic 2 (5.10) listed Toxicology and Environmental Mutagenesis 655 (1- under IIA 2):41-46. DOI 8.16 10.1016/j.mrgentox.2008.06.010.

IIA 5.10 Cavas T, Konen S 2007 Detection of cytogenetic and DNA damage in 2 (8.16) K Also peripheral erythrocytes of goldfish (Carassius 3 (5.10) listed auratus) exposed to a glyphosate formulation using E under IIA the micronucleus test and the comet assay. 8.16 Mutagenesis 22 (4):263-8. DOI: 10.1093/mutage/gem012.

IIA 5.10 Çavuşoğlu K, Yapar K, 2011 Protective Effect of Ginkgo biloba L. Leaf Extract 2 Oruç E, Yalçın E Against Glyphosate Toxicity in Swiss Albino Mice Journal of Medicinal Food. 14 (10):1263-1272. DOI: 10.1089/jmf.2010.0202.

Page 58 of 192

- 59 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Chan YC, Chang SC, 2007 Cardiovascular effects of herbicides and formulated 1 Hsuan SC, Chien MS, adjuvants on isolated rat aorta and heart. Toxicology Lee WC, Kang JJ, Wang in Vitro 21 (4):595-603. DOI SC, Liao JW 10.1016/j.tiv.2006.12.007.

IIA 5.10 Chang CB, Chang CC 2009 Refractory cardiopulmonary failure after 1 glyphosate surfactant intoxication: a case report. J Occup Med Toxicol 4:2. DOI: 10.1186/1745-6673-4-2.

IIA 5.10 Chatzi L, Alegakis A, 2007 Association of allergic rhinitis with pesticide use 1 Tzanakis N, Siafakas N, among grape farmers in Crete, Greece. Occup Kogevinas M, Lio- nis C Environ Med 64 (6):417-21. DOI: 10.1136/oem.2006.029835.

IIA 5.10 Clair E, Linn L, Travert C, 2012 Effects of Roundup and Glyphosate on Three Food 3 K Amiel C, Seralini G- E, Microorganisms: Geotrichum candidum, Lactococcus Panoff J-M lactis subsp. cremoris and Lactobacillus delbrueckii subsp. bulgaricus. Current Microbiology 64 (5):486- 91

IIA 5.10 Clair E, Mesnage R, 2010 A glyphosate-based herbicide results in necrosis and 3 Gress R, Travert C, apoptosis of testicular cells in mature rats [Un Seralini G herbicide à base de glyphosate induit la nécrose et l’apoptose des cellules testiculaires de rats matures]. Paper read at 27e congrès de la Société francaise d’endocrinologie, 29 September - 2 October, 2010, at Deauville, France.

IIA 5.10 Clair É, Mesnage R, 2012 A glyphosate-based herbicide induces necrosis and 3 K Travert C, Séralini G-É apoptosis in mature rat testicular cells in vitro, and testosterone decrease at lower levels. Toxicology in Vitro 26 (2):269-279. DOI: 10.1016/j.tiv.2011.12.009.

IIA 5.10 Cole RD, Anderson 2004 The nematode Caenorhabditis elegans as a model of 1 GL, Williams PL organophosphate-induced mammalian neurotoxicity. Toxicology and Applied Pharmacology 194 (3):248- 256. DOI 10.1016/j.taap.2003.09.013.

IIA 5.10 Curwin BD, Hein MJ, 2005 Pesticide contamination inside farm and nonfarm 1 Sanderson WT, Nishi- oka homes. Journal of Occupational and Environmental MG, Reynolds SJ, Ward Hygiene 2 (7):357-367. Doi EM, Alavanja MC 10.1080/15459620591001606.

IIA 5.10 Curwin BD, Hein MJ, 2007 Pesticide dose estimates for children of Iowa 1 Sanderson WT, Striley C, farmers and non-farmers. Environmental Re- search Heederik D, Krom- hout 105 (3):307-315. DOI: H, Reynolds SJ, Alavanja 10.1016/j.envres.2007.06.001. MC

IIA 5.10 Curwin BD, Hein MJ, 2007 Urinary pesticide concentrations among children, 1 Sanderson WT, Striley C, mothers and fathers living in farm and non-farm Heederik D, Krom- hout households in iowa. Ann Occup Hyg 51 (1):53-65. H, Reynolds SJ, Alavanja DOI: MC 10.1093/annhyg/mel062.

IIA 5.10 da Costa MDL, Gon- calves 2003 Neuroimaging abnormalities in parkinsonism: study 2 LR, Barbosa ER, Bacheschi of five cases. Arquivos De Neuro- Psiquiatria 61 LA (2B):381-386

Page 59 of 192

- 60 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Dallegrave E, 2002 Oral acute toxicity of glyphosate in Wistar rats. Online 2 Digiorgio MF, Journal of Veterinary Research 1:29-34 Dalsenter PR, A. L IIA 5.10 Dallegrave E, Mantese FD, 2003 The teratogenic potential of the herbicide 3 E K Coelho RS, Pereira JD, glyphosate-Roundup (R) in Wistar rats. Toxi- cology Dalsenter PR, Lan- geloh A Letters 142 (1-2):45-52

IIA 5.10 Dallegrave E, Mantese FD, 2007 Pre- and postnatal toxicity of the commercial 3 E K Oliveira RT, Andrade AJM, glyphosate formulation in Wistar rats. Archi- ves of Dalsenter PR, Langeloh A Toxicology 81 (9):665-673. DOI 10.1007/s00204-006-0170-5. IIA 5.10 Daruich J, Zirulnik F, 2001 Effect of the herbicide glyphosate on enzymatic 3 K Gimenez MS activity in pregnant rats and their fetuses. Environmental Research 85 (3):226- 231. DOI 10.1006/enrs.2000.4229.

IIA 5.10 Davanzo F, Settimi L, 2004 [Agricultural pesticide-related poisonings in Italy: 1 Faraoni L, Maiozzi P, cases reported to the Poison Control Centre of Travaglia A, Marcello I Milan in 2000-2001]. Epidemiol Prev 28 (6):330-7

IIA 5.10 Dawson AH, Eddleston M, 2010 Acute Human Lethal Toxicity of Agricultural 1 Senarathna L, Mohamed F, Pesticides: A Prospective Cohort Study. Plos Gawarammana I, Bowe SJ, Medicine 7 (10) Manuweera G, Buckley NA

IIA 5.10 Dayton SB, Sandler DP, 2010 Pesticide use and myocardial infarction incidence 1 Blair A, Alavanja MC, among farm women in the agricultural health study. Beane Freeman LE, Journal of Occupati- onal and Environmental Hoppin JA Medicine 52 (7):693- 697. doi: 10.1097/JOM.0b013e3181e66d25.

IIA 5.10 De Roos AJ, Blair A, 2005 Cancer incidence among glyphosate-exposed 2 E K Rusiecki JA, Hoppin JA, pesticide applicators in the agricultural health study. Svec M, Dosemeci M, Environmental Health Perspectives 113 (1):49-54 Sandler DP, Alavanja MC

IIA 5.10 De Roos AJ, Zahm SH, 2003 Integrative assessment of multiple pesticides as risk 3 K Cantor KP, Weisenburger factors for non-Hodgkin's lymphoma among men. DD, Holmes FF, Occupational and Environmental Medicine 60 (9):- Burmeister LF, Blair A E11

IIA 5.10 Dimitrov BD, Gadeva 2006 Comparative genotoxicity of the herbicides 1 PG, Benova DK, Bineva Roundup, Stomp and Reglone in plant and MV mammalian test systems. Mutagenesis 21 (6):375- 82. DOI: 10.1093/mutage/gel044.

IIA 5.10 El-Demerdash FM, 2001 Influence of paraquat, glyphosate, and cadmium on 2 Yousef MI, Elagamy EI the activity of some serum enzymes and protein electrophoretic behavior (in vitro). Journal of Environmental Science and Health Part B-Pesticides Food Contaminants and Agricultural Wastes 36 (1):29-42

IIA 5.10 Elie-Caille C, Heu C, 2010 Morphological damages of a glyphosate- treated 1 Guyon C, Nicod L human keratinocyte cell line revealed by a micro- to nanoscale microscopic investigation. Cell Biol Toxicol 26 (4):331-9. DOI: 10.1007/s10565-009- 9146-6.

Page 60 of 192

- 61 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 El-Shenawy NS 2009 Oxidative stress responses of rats exposed to 1 Roundup and its active ingredient glyphosate. Environmental Toxicology and Pharmacology 28 (3):379-385

IIA 5.10 Engel LS, Checkoway H, 2001 Parkinsonism and occupational exposure to 1 Keifer MC, Seixas NS, pesticides. Occup Environ Med 58 (9):582-9 Longstreth WT, Jr., Scott KC, Hudnell K, Anger WK, Camici- oli R

IIA 5.10 Engel LS, Hill DA, 2005 Pesticide use and breast cancer risk among farmers' 1 Hoppin JA, Lubin JH, wives in the agricultural health study. American Lynch CF, Pierce J, Journal of Epidemiology 161 (2):121-135. doi: Samanic C, Sandler DP, 10.1093/aje/kwi022. Blair A, Alavanja MC

IIA 5.10 Eriksson M, Hardell L, 2008 Pesticide exposure as risk factor for non- 3 E K Carlberg M, Akerman M Hodgkin lymphoma including histopathological subgroup analysis. Int J Can- cer 123 (7):1657-63. DOI: 10.1002/ijc.23589.

IIA 5.10 Felsot AS 2011 Pesticides Health Myths vs. Realities. American 1 Council on Science and Health IIA 5.10 Firth HM, Rothstein 2007 Chemical exposure among NZ farmers. Int J 1 DS, Herbison GP, Environ Health Res 17 (1):33-43. DOI: McBride DI 10.1080/09603120601124181. IIA 5.10 Fisher KR, Higginbotham 2008 Pesticide-associated pemphigus vulgaris. Cutis 1 R, Frey J, Granese J, 82 (1):51-4 Pillow J, Skinner RB

IIA 5.10 Flower KB, Hoppin 2004 Cancer risk and parental pesticide application in 1 JA, Lynch CF, Blair A, children of agricultural health study participants. Knott C, Shore DL, Environmental Health Perspecti- ves 112 (5):631- Sandler DP 635

IIA 5.10 Forgacs AL, Ding Q, 2012 BLTK1 Murine Leydig Cells: A Novel Steroidogenic 1 Jaremba RG, Model for Evaluating the Effects of Reproductive and Huhtaniemi IT, Rahman Developmental Toxicants. Toxicological Sciences. NA, Zacharewski TR DOI: 10.1093/toxsci/kfs121.

IIA 5.10 Frappart M, Vouriot D, 2011 A fatal acute poisoning with glyphosate: 1 Lemoine L, Floch T, Leon Importance of gastrointestinal toxicity. A Annales Francaises D Anesthesie Et De Reanimation 30 (11):852-854. doi: 10.1016/j.annfar.2011.07.006.

IIA 5.10 Freeman LB 2009 Evaluation of agricultural exposures: the agricultural 1 health study and the agricultural cohort consortium. Reviews on Environmental Health 24 (4, Sp. Iss. SI):311-318

IIA 5.10 Fritschi L, Benke G, 2005 Occupational exposure to pesticides and risk of non- 2 K Hughes AM, Kricker A, Hodgkin's lymphoma. American Journal Turner J, Vajdic CM, of Epidemiology 162 (9):849-857. Doi Grulich A, Milli- ken S, 10.1093/Aje/Kwi292. Kaldor J, Arm- strong BK

IIA 5.10 Garry VF 2004 Pesticides and children. Toxicology and 2 Applied Pharmacology 198 (2):152-163. DOI 10.1016/j.taap.2003.11.027.

Page 61 of 192

- 62 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Garry VF, Harkins ME, 2002 Birth defects, season of conception, and sex of 3 E K Erickson LL, Long- children born to pesticide applicators living in the Simpson LK, Holland SE, Red River Valley of Minnesota, USA. Environmental Burroughs BL Health Perspectives 110:441- 449

IIA 5.10 Garry VF, Holland SE, 2003 Male reproductive hormones and thyroid function in 3 K Erickson LL, Burroughs pesticide applicators in the Red River Valley of BL Minnesota. Journal of Toxico- logy and Environmental Health-Part A 66 (11):965-986. Doi 10.1080/15287390390212792.

IIA 5.10 Gasnier C, Benachour N, 2010 Dig1 protects against cell death provoked by 2 Clair E, Travert C, glyphosate-based herbicides in human liver cell Langlois F, Laurant C, lines. J Occup Med Toxicol 5:29. DOI: Decroix-Laporte C, 10.1186/1745-6673-5-29. Seralini GE

IIA 5.10 Gasnier C, Dumont C, 2009 Glyphosate-based herbicides are toxic and endocrine 3 E K Benachour N, Clair E, disruptors in human cell lines. Toxi- cology 262 Chagnon MC, Seralini GE (3):184-191. DOI: 10.1016/j.tox.2009.06.006.

IIA 5.10 Gasnier C, Laurant C, 2011 Defined plant extracts can protect human cells 2 Decroix-Laporte C, against combined xenobiotic effects. J Occup Med Mesnage R, Clair E, Toxicol 6 (1):3. DOI: 10.1186/1745- Travert C, Seralini GE 6673-6-3.

IIA 5.10 Gehin A, Guillaume YC, 2005 Vitamins C and E reverse effect of herbicide- induced 2 Millet J, Guyon C, Nicod L toxicity on human epidermal cells HaCaT: a biochemometric approach. Internati- onal Journal of Pharmaceutics 288 (2):219- 226. DOI 10.1016/j.ijpharm.2004.09.024.

IIA 5.10 Gehin A, Guyon C, 2006 Glyphosate-induced antioxidant imbalance in 2 Nicod L HaCaT: The protective effect of vitamins C and E. Environmental Toxicology and Pharmacology 22 (1):27-34. DOI 10.1016/j.etap.2005.11.003.

IIA 5.10 Gencer N, Arslan O 2011 In vitro effects of some pesticides on PON1Q192 and 1 PON1R192 isoenzymes from human serum. Fresenius Environmental Bulle- tin 20 (3):590-596

IIA 5.10 George J, Prasad S, 2010 Studies on glyphosate-induced carcinogenicity in 2 E K Mahmood Z, Shukla Y mouse skin: a proteomic approach. J Prote- omics 73 (5):951-64. DOI: 10.1016/j.jprot.2009.12.008.

IIA 5.10 Goldner WS, Sandler DP, 2010 Pesticide use and thyroid disease among women in 1 Yu F, Hoppin JA, Kamel the Agricultural Health Study. Am J Epidemiol 171 F, Levan TD (4):455-64. DOI: 10.1093/aje/kwp404.

IIA 5.10 Goldstein DA, Acqua- 2002 An analysis of glyphosate data from the California 1 vella JF, Mannion RM, Environmental Protection Agency Pesticide Illness Farmer DR Surveillance Program. Journal of Toxicology-Clinical Toxicology 40 (7):885- 892. Doi 10.1081/Clt-120016960.

Page 62 of 192

- 63 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Goldstein DA, Dubel- 2012 Comment: Aris and Leblanc "Maternal and fetal 1 man S, Grothaus D, exposure to pesticides associated to genetically Hammond BG modified foods in Eastern Townships of Quebec, Canada". Reproductive Toxicology 33 (1):120-121. doi: 10.1016/j.reprotox.2011.10.007.

IIA 5.10 Greenlee AR, Arbuckle 2003 Risk factors for female infertility in an agricultural 2 TE, Chyou PH region. Epidemiology 14 (4):429- 436. Doi 10.1097/01.Ede.0000071407.15670.Aa.

IIA 5.10 Grisolia CK 2002 A comparison between mouse and fish micronucleus 1 Also test using cyclophosphamide, mitomycin C and listed various pesticides. Mutation Research-Genetic under IIA Toxicology and Environ- mental Mutagenesis 518 8.16 (2):145-150

IIA 5.10 Gui Y-x, Fan X-n, Wang 2012 Glyphosate induced cell death through apoptotic and 3 K H-m, Wang G, Chen S-d autophagic mechanisms. Neuro- toxicology and Teratology 34 (3):344-349. DOI: 10.1016/j.ntt.2012.03.005.

IIA 5.10 Guilherme S, Gaivão I, 2010 European eel (Anguilla anguilla) genotoxic and pro- 3 (8.16) K Also Santos MA, Pacheco M oxidant responses following short-term exposure to 2 (5.10) listed Roundup®—a glyphosate-based herbicide. E under IIA Mutagenesis 25 (5):523-530. DOI: 8.16 10.1093/mutage/geq038.

IIA 5.10 Han SK, Jeong J, Yeom S, 2010 Use of a lipid emulsion in a patient with refractory 1 Ryu J, Park S hypotension caused by glyphosate- surfactant herbicide. Clin Toxicol (Phila) 48 (6):566-8. DOI: 10.3109/15563650.2010.496730.

IIA 5.10 Hardell L, Eriksson M 1999 A case-control study of non-Hodgkin lymphoma and E K exposure to pesticides. Cancer 85 (6):1353-1360. doi: 10.1002/(sici)1097- 0142(19990315)85:6<1353::aid- cncr19>3.0.co;2-1.

IIA 5.10 Hardell L, Eriksson M, 2002 Exposure to pesticides as risk factor for non- 3 E K Nordstrom M Hodgkin's lymphoma and hairy cell leukemia: Pooled analysis of two Swedish case-control studies. Leukemia & Lymphoma 43 (5):1043- 1049. Doi 10.1080/10428190290021560.

IIA 5.10 Hecker M, Hollert H, 2011 The OECD validation program of the H295R 1 Cooper R, Vinggaard AM, steroidogenesis assay: Phase 3. Final inter- Akahori Y, Mur- phy M, laboratory validation study. Environmental Science Nellemann C, Higley E, and Pollution Research 18 (3):503- Newsted J, Laskey J, 515. doi: 10.1007/s11356-010-0396-x. Buckalew A, Grund S, Maletz S, Giesy J, Timm G IIA 5.10 Helal AD, Moussa HM 2005 Chromosomal aberrations induced by glyphosate 2 isopropylamine herbicide and trials for diminuting its toxicity using some chemical inactivators and antioxidant. Veterinary Medi- cal Journal Giza 53 (2, Pt. 1):169-187

IIA 5.10 Heras-Mendaza F, 2008 Erythema multiforme-like eruption due to an irritant 2 Casado-Farinas I, contact dermatitis from a glyphosate pesticide. Contact Paredes-Gascon M, Dermatitis 59 (1):54-6. DOI: Conde-Salazar L 10.1111/j.1600-0536.2007.01307.x.

Page 63 of 192

- 64 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Heu C, Berquand A, Elie- 2012 Glyphosate-induced stiffening of HaCaT 3 K Caille C, Nicod L keratinocytes, a Peak Force Tapping study on living cells. Journal of structural biology 178 (1):1-7

IIA 5.10 Heu C, Elie-Caille C, 2012 A step further toward glyphosate-induced epidermal 3 K Mougey V, Launay S, cell death: Involvement of mitochondrial and Nicod L oxidative mechanisms. Environmental Toxicology and Pharmacology 34 (2):144-153. DOI: 10.1016/j.etap.2012.02.010.

IIA 5.10 Heydens WF, Healy CE, 2008 Genotoxic potential of glyphosate formulations: 1 Hotz KJ, Kier LD, Mode-of-action investigations. Journal of Agricultural Martens MA, Wilson and Food Chemistry 56 (4):1517-1523. Doi AGE, Farmer DR 10.1021/Jf072581i.

IIA 5.10 Hokanson R, Fudge R, 2007 Alteration of estrogen-regulated gene expression in 2 E K Chowdhary R, Busbee D human cells induced by the agricultural and horticultural herbicide glyphosate. Hum Exp Toxicol 26 (9):747-52. DOI: 10.1177/0960327107083453.

IIA 5.10 Holeckova B 2006 Evaluation of the in vitro effect of glyphosate- based 2 herbicide on bovine lymphocytes using chromosome painting. Bulletin of the Veterina- ry Research Institute in Pulawy 50 (4):533-536

IIA 5.10 Hopa E, Sinan S, Turan 2011 The inhibitory effects of some pesticides on 2 Y human erythrocyte glucose-6-phosphate dehydrogenase activity (in vitro). Fresenius Environmental Bulletin 20 (5A):1314-1319

IIA 5.10 Hoppin JA, Umbach DM, 2002 Chemical predictors of wheeze among farmer 1 London SJ, Ala- vanja pesticide applicators in the Agricultural Health Study. MC, Sandler DP Am J Respir Crit Care Med 165 (5):683-9

IIA 5.10 Hoppin JA, Umbach DM, 2008 Pesticides and atopic and nonatopic asthma among 1 London SJ, Hen- neberger farm women in the Agricultural Health Study. Am J PK, Kullman GJ, Respir Crit Care Med 177 (1):11- Alavanja MC, Sandler DP 8. DOI: 10.1164/rccm.200706-821OC.

IIA 5.10 Hoppin JA, Umbach DM, 2009 Pesticide use and adult-onset asthma among male 1 London SJ, Hen- neberger farmers in the Agricultural Health Study. Eur Respir PK, Kullman GJ, Coble J, J 34 (6):1296-303. DOI: Alavanja MC, Beane 10.1183/09031936.00005509. Freeman LE, Sandler DP

IIA 5.10 Hoppin JA, Umbach DM, 2006 Pesticides associated with wheeze among 1 London SJ, Lynch CF, commercial pesticide applicators in the Alavanja MC, Sandler DP Agricultural Health Study. Am J Epidemiol 163 (12):1129-37. DOI: 10.1093/aje/kwj138.

IIA 5.10 Hoppin JA, Valcin M, 2007 Pesticide use and chronic bronchitis among farmers in 1 Henneberger PK, Kullman the Agricultural Health Study. Am J Ind Med 50 GJ, Umbach DM, London (12):969-79. DOI: SJ, Ala- vanja MC, 10.1002/ajim.20523. Sandler DP

IIA 5.10 Hsiao CT, Lin LJ, Hsiao 2008 Acute pancreatitis caused by severe glyphosate- 1 KY, Chou MH, Hsiao SH surfactant oral intoxication. Am J Emerg Med 26 (3):384 e3-5. DOI: 10.1016/j.ajem.2007.06.024.

Page 64 of 192

- 65 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Hultberg M 2007 Cysteine turnover in human cell lines is influenced by 2 glyphosate. Environmental To- xicology and Pharmacology 24 (1):19-22. DOI 10.1016/j.etap.2007.01.002.

IIA 5.10 Inazu N, Fujii T 2004 Changes in testicular carbonyl reductase in rats 1 T exposed in utero to glyphosate, herbicide. Bulletin of Teikyo Heisei Junior College 14:39-45

IIA 5.10 Ishiguro M, Mikasa S, 2004 [A case of acute poisoning caused by the inhalation of 1 Otani M a nonselective herbicide REBIN GT SC (butafenacil and glyphosate isopropylamine)]. Chudoku Kenkyu 17 (1):51- 4

IIA 5.10 Ivanov I, Halkova ZH, 2001 Cytotoxicity induced by herbicides glyphosate and 1 Tsolova S, Simeonov K, alachlor in vitro. Experimental Pathology and Sainova I, Tasheva M Parasitology 4 (6):20-26

IIA 5.10 Johnson PD, Rimmer DA, 2005 Operator exposure when applying amenity 1 Garrod AN, Helps JE, herbicides by all-terrain vehicles and Mawdsley C controlled droplet applicators. Ann Occup Hyg 49 (1):25-32. DOI: 10.1093/annhyg/meh073.

IIA 5.10 Kale PG, Petty BT, Walker 1995 Mutagenicity testing of 9 herbicides and pesticides E K S, Ford JB, Dehkordi N, currently used in agriculture. Envi- ronmental and Tarasia S, Tasie BO, Kale Molecular Mutagenesis 25 (2):148-153. doi: R, Sohni YR 10.1002/em.2850250208.

IIA 5.10 Kamel F, Hoppin JA 2004 Association of pesticide exposure with neurologic 1 dysfunction and disease. Environ- mental Health Perspectives 112 (9):950-958. Doi 10.1289/Ehp.7135.

IIA 5.10 Kamel F, Tanner CM, 2007 Pesticide exposure and self-reported Parkinson's 1 Umbach DM, Hoppin JA, disease in the agricultural health study. American Alavanja MCR, Blair A, Journal of Epidemiology 165 (4):364-374. Doi Comyns K, Goldman SM, 10.1093/Aje/Kwk024. Korell M, Langston JW, Ross GW, Sandler DP

IIA 5.10 Kamijo Y, Mekari M, 2012 Glyphosate-surfactant herbicide products containing 1 Yoshimura K, Kan’o, glyphosate potassium salt can cause fatal Tomomichi, Soma K hyperkalemia if ingested in massive amounts. Clinical Toxicology 50 (2):159-159. doi:10.3109/15563650.2011.648747.

IIA 5.10 Kang J-F, Zeng M, 2008 Study on Mutagenesis Induced by Glyphosate in 2 T Guan L, Guo J-M, Mice. Carcinogenesis, Teratogenesis & Mutagenesis Chen P, Zhong C-G (Aibian, Jibian, Tubian) 20(3) :227-230. 20 (3):227-230

IIA 5.10 Karunanayake CP, Spinelli 2011 Hodgkin Lymphoma and Pesticides Exposure in Men: 1 JJ, McLaughlin JR, A Canadian Case-Control Study. Jour- nal of Dosman JA, Pahwa P, Agromedicine 17 (1):30-39. DOI: McDuffie HH 10.1080/1059924x.2012.632726.

IIA 5.10 Keim SA, Alavanja 2001 Pesticide use by persons who reported a high 1 MC pesticide exposure event in the agricultural health study. Environ Res 85 (3):256-9. DOI: 10.1006/enrs.2000.4224.

Page 65 of 192

- 66 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Kirby RS 2002 Re: “Case-cohort analysis of agricultural pesticide 1 applications near maternal residence and selected causes of fetal death”. American Journal of Epidemiology 155 (8):779-780. doi: 10.1093/aje/155.8.779.

IIA 5.10 Kirrane EF, Hoppin JA, 2005 Retinal degeneration and other eye disorders in wives 1 Kamel F, Umbach DM, of farmer pesticide applicators enrolled in the Boyes WK, De- Roos AJ, agricultural health study. American Journal of Alavanja M, Sandler DP Epidemiology 161 (11):1020-1029. Doi 10.1093/Aje/Kwi140.

IIA 5.10 Knopper LD, Lean 2004 Carcinogenic and genotoxic potential of turf 1 DRS pesticides commonly used on golf courses. Journal of Toxicology and Environmental Health-Part B-Critical Reviews 7 (4):267-279. Doi 10.1080/10937400490452697.

IIA 5.10 Kojima H, Katsura E, 2004 Screening for estrogen and androgen receptor 1 Takeuchi S, Niiyama K, activities in 200 pesticides by in vitro reporter gene Kobayashi K assays using Chinese hamster ovary cells. Environmental Health Perspectives 112 (5):524-531

IIA 5.10 Kojima H, Sata F, 2011 Comparative study of human and mouse pregnane X 1 Takeuchi S, Sueyoshi T, receptor agonistic activity in 200 pesticides using in Nagai T vitro reporter gene assays. Toxicology 280 (3):77- 87. doi: 10.1016/j.tox.2010.11.008.

IIA 5.10 Kramer V, Blewett C, 2008 Comments on "Evaluation of Estrogenic 2 (8.16) Also Gersich M Activities of Aquatic Herbicides and 1 (5.10) listed Surfactants Using a Rainbow Trout under IIA Vitellogenin Assay". Toxicol. Sci. 104 (1):228- 8.16 230. DOI: 10.1093/toxsci/kfn067.

IIA 5.10 Kudo K, Ishida T, Hikiji 2010 Pattern of poisoning in Japan: selection of drugs and 1 W, Usumoto Y, Umehara poisons for systematic toxicological analysis. T, Nagamatsu K, Tsuji A, Forensic Toxicology 28 (1):25-32. DOI: Ikeda N 10.1007/s11419-009-0088-8.

IIA 5.10 Landgren O, Kyle RA, 2009 Pesticide exposure and risk of monoclonal 1 Hoppin JA, Freeman LEB, gammopathy of undetermined significance in the Cerhan JR, Katzmann JA, Agricultural Health Study. Blood 113 (25):6386- Rajku- mar SV, Alavanja 6391. DOI 10.1182/blood-2009-02- MC 203471.

IIA 5.10 Lash TL 2007 Bias analysis applied to Agricultural Health Study 2 publications to estimate non-random sources of uncertainty. J Occup Med Toxicol 2:15. DOI: 10.1186/1745-6673-2-15.

IIA 5.10 Lebailly P, Devaux A, 2003 Urine mutagenicity and lymphocyte DNA damage in 1 Pottier D, De Meo M, fruit growers occupationally exposed to the fungicide Andre V, Baldi I, Severin captan. Occupational and Environmental Medicine F, Bernaud J, Durand B, 60 (12):910-917 Henry-Amar M, Gauduchon P

IIA 5.10 Lee CH, Shih CP, Hsu 2008 The early prognostic factors of glyphosate- surfactant 1 KH, Hung DZ, Lin CC intoxication. Am J Emerg Med 26 (3):275-81. DOI: 10.1016/j.ajem.2007.05.011.

Page 66 of 192

- 67 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Lee HL, Guo HR 2011 The hemodynamic effects of the formulation of 1 glyphosate-surfactant herbicides. In Herbicides, Theory and Applications, edited by S. Soloneski and M. L. Larramendy. Croatia. InTech. pp 545-566.

IIA 5.10 Lee HL, Kan CD, Tsai 2009 Comparative effects of the formulation of 1 CL, Liou MJ, Guo HR glyphosate-surfactant herbicides on hemodynamics in swine. Clin Toxicol (Phila) 47 (7):651-8. DOI: 10.1080/15563650903158862.

IIA 5.10 Lee WJ, Colt JS, Hei- 2005 Agricultural pesticide use and risk of glioma in 2 neman EF, McComb R, Nebraska, United States. Occupational and Weisenburger DD, Lijinsky Environmental Medicine 62 (11):-. DOI W, Ward MH 10.1136/oem.2005.020230.

IIA 5.10 Lee WJ, Lijinsky W, 2004 Agricultural pesticide use and adenocarcinomas of 1 Heineman EF, Markin RS, the stomach and oesophagus. Occupational and Weisenburger DD, Ward Environmental Medicine 61 (9):743-749. DOI MH 10.1136/oem.2003.011858.

IIA 5.10 Levine SL, Han Z, Liu J, 2007 Disrupting mitochondrial function with surfactants 1 Farmer DR, Papadopoulos inhibits MA-10 Leydig cell steroidogenesis. Cell V Biol Toxicol 23 (6):385- 400. DOI: 10.1007/s10565-007-9001-6.

IIA 5.10 Lord RCC 2001 The toxicology of herbicides. Medical 1 Biochemistry 1:315-323 IIA 5.10 Love BJ, Einheuser 2011 Effects on aquatic and human health due to large 1 MD, Nejadhashemi AP scale bioenergy crop expansion. Science of the Total Environment 409 (17):3215-3229. doi: 10.1016/j.scitotenv.2011.05.007.

IIA 5.10 Lueken A, Juhl-Strauss 2004 Synergistic DNA damage by oxidative stress (induced 2 U, Krieger G, Witte I by H2O2) and nongenotoxic environmental chemicals in human fibroblasts. Toxicology Letters 147 (1):35- 43. DOI 10.1016/j.toxlet.2003.10.020.

IIA 5.10 Machado Neto JG, 2007 Evaluation of Herbicide Application Using Backpack 1 Machado RF Sprayers for Post-Emergence Weed Control in Sugar Cane Crop and Safe Work Conditions. Planta Daninha 25 (4):877-887

IIA 5.10 Mage DT 2006 Suggested corrections to the Farm Family 1 E K Exposure Study. Environmental Health Per- spectives 114 (11): A633 IIA 5.10 Malatesta M, Perdoni F, 2008 Hepatoma tissue culture (HTC) cells as a model for 2 Santin G, Battistelli S, investigating the effects of low concentrations of Muller S, Biggiogera M herbicide on cell structure and function. Toxicol In Vitro 22 (8):1853-60. DOI: 10.1016/j.tiv.2008.09.006.

IIA 5.10 Malhotra RC, Ghia 2010 Glyphosate-surfactant herbicide-induced reversible 1 DK, Cordato DJ, Beran encephalopathy. J Clin Neurosci 17 (11):1472-3. DOI: RG 10.1016/j.jocn.2010.02.026. IIA 5.10 Manas F, Peralta L, 2009 Genotoxicity of AMPA, the environmental 2 E K Raviolo J, Ovando HG, metabolite of glyphosate, assessed by the Comet Weyers A, Ugnia L, assay and cytogenetic tests. Ecotoxico- Cid MG, Larripa I, logy and Environmental Safety 72 (3):834-837. DOI Gorla N 10.1016/j.ecoenv.2008.09.019.

Page 67 of 192

- 68 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Manas F, Peralta L, 2009 Genotoxicity of glyphosate assessed by the comet 2 E K Raviolo J, Ovandoa HG, assay and cytogenetic tests. Environ- mental Weyers A, Ugnia L, Cid Toxicology and Pharmacology 28 (1):37-41. DOI MG, Larripa I, Gorla N 10.1016/j.etap.2009.02.001.

IIA 5.10 Mandel JS, Alexander BH, 2005 Biomonitoring for farm families in the farm family 1 Baker BA, Acquavella JF, exposure study. Scand J Work Environ Health 31 Chapman P, Honeycutt R Suppl 1:98-104; discussion 63-5 IIA 5.10 Marc J, Belle R, Morales 2004 Formulated glyphosate activates the DNA- response 3 E K J, Cormier P, Mulner- checkpoint of the cell cycle leading to the prevention Lorillon O of G2/M transition. Toxicologi- cal Sciences 82 (2):436-442. DOI 10.1093/toxsci/kfh281.

IIA 5.10 Marc J, Mulner- 2004 Glyphosate-based pesticides affect cell cycle 3 E K Lorillon O, Belle R regulation. Biology of the Cell 96 (3):245-249. DOI 10.1016/j.biolcel.2003.11.010. IIA 5.10 Marc J, Mulner- Lorillon 2003 Embryonic cell cycle for risk assessment of pesticides 3 K O, Durand G, Belle R at the molecular level. Environmen- tal Chemistry Letters 1 (1):8-12. DOI 10.1007/s10311-002-0015-2.

IIA 5.10 Martinez A, Reyes I, 2007 [Cytotoxicity of the herbicide glyphosate in human 1 Reyes N peripheral blood mononuclear cells]. Biomedica 27 (4):594-604 IIA 5.10 McCoy KA, Bortnick LJ, 2008 Agriculture alters gonadal form and function in the 1 Also Campbell CM, Hamlin toad Bufo marinus. Environ Health Per- spect 116 listed HJ, Guillette LJ, St Mary (11):1526-32. DOI: under IIA CM 10.1289/ehp.11536. 8.16

IIA 5.10 McDaniel TV, Martin PA, 2008 Potential endocrine disruption of sexual development 1 Also Struger J, Sherry J, Marvin in free ranging male northern leopard frogs (Rana listed CH, McMaster ME, pipiens) and green frogs (Rana clamitans) from areas under IIA Clarence S, Tetreault G of intensive row crop agriculture. Aquat Toxicol 88 8.16 (4):230-42. DOI: 10.1016/j.aquatox.2008.05.002.

IIA 5.10 McDuffie HH, Pahwa P, 2001 Non-Hodgkin's lymphoma and specific pesticide 1 McLaughlin JR, Spinelli JJ, exposures in men: cross-Canada study of pesticides Fincham S, Dosman JA, and health. Cancer Epide- miol Biomarkers Prev 10 Robson D, Skinnider LF, (11):1155-63 Choi NW

IIA 5.10 McQueen H, Callan 2012 Estimating maternal and prenatal exposure to 1 AC, Hinwood AL glyphosate in the community setting. International Journal of Hygiene and Environmental Health. DOI: 10.1016/j.ijheh.2011.12.002.

IIA 5.10 Menendez-Helman RJ, 2012 Glyphosate as an Acetylcholinesterase Inhibitor in 2 Also Ferreyroa GV, dos Santos Cnesterodon decemmaculatus. Bulletin of listed Afonso M, Salibian A Environmental Contamination and Toxicology 88 under IIA (1):6-9. doi: 10.1007/s00128- 8.16 011-0423-8.

IIA 5.10 Mesnage R, Clair E, Gress 2012 Cytotoxicity on human cells of Cry1Ab and Cry1Ac 3 K S, Then C, Székács A, Bt insecticidal toxins alone or with a glyphosate-based Séralini GE herbicide. Journal of Applied Toxicology:n/a-n/a. DOI: 10.1002/jat.2712.

Page 68 of 192

- 69 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Meulenberg EP 2002 A new test to identify endocrine disruptors using 1 sex hormone-binding globulins from human serum. European Journal of Lipid Science and Technology 104 (2):131-136

IIA 5.10 Miligi L, Costantini AS, 2003 Non-Hodgkin's lymphoma, leukemia, and exposures 1 Bolejack V, Veraldi A, in agriculture: Results from the Italian multicenter Benvenuti A, Nanni O, case-control study. Ameri- can Journal of Industrial Ramazzotti V, Tumino R, Medicine 44 (6):627- Stagnaro E, Rodella 636. Doi 10.1002/Ajim.10289. S, Fontana A, Vindigni C, Vineis P

IIA 5.10 Mills KT, Blair A, 2009 Pesticides and Myocardial Infarction Incidence and 1 Freeman LEB, Sandler Mortality Among Male Pesticide Applicators in the DP, Hoppin JA Agricultural Health Study. American Journal of Epidemiology 170 (7):892-900. Doi 10.1093/Aje/Kwp214.

IIA 5.10 Mink PJ, Mandel JS, 2011 Epidemiologic studies of glyphosate and non- cancer 1 Lundin JI, Sceurman health outcomes: A review. Regulatory Toxicology BK and Pharmacology 61 (2):172-184. doi: 10.1016/j.yrtph.2011.07.006.

IIA 5.10 Mitsuse M, Hatano Y, 2011 Japan Poison Information Center: An 1 Endo Y, Kuroki Y, Epidemiological Analysis of Cases of Acute Fukuya C, Shirakawa Y, Glyphosate Poisoning. Jpn. J. Clin. Toxicol. Yoshioka T 24:69-72

IIA 5.10 Mladinic M, Berend S, 2009 Evaluation of genome damage and its relation to 3 K Vrdoljak AL, Kopjar N, oxidative stress induced by glyphosate in human Radic B, Zeljezic D lymphocytes in vitro. Environmental and Molecular Mutagenesis 50 (9):800-807. DOI: 10.1002/em.20495.

IIA 5.10 Mladinic M, Perkovic 2009 Characterization of chromatin instabilities induced 3 K P, Zeljezic D by glyphosate, terbuthylazine and carbofuran using cytome FISH assay. Toxicol Lett 189 (2):130-7. DOI: 10.1016/j.toxlet.2009.05.012.

IIA 5.10 Momesso JC, Machado 2003 Effects of herbicide spraying period and 1 Neto JG volume on the safety of tractor drivers spraying herbicides on sugarcane (Saccharum spp.) crop. Planta Daninha 21 (3):467-478

IIA 5.10 Monge P, Wesseling C, 2007 Parental occupational exposure to pesticides and the 1 Guardado J, Lundberg risk of childhood leukemia in Costa Rica. I, Ahlbom A, Cantor Scandinavian Journal of Work Environ- ment & KP, Weideroass E, Health 33 (4):293-303 Partanen T

IIA 5.10 Monroy CM, Cortes 2005 Cytotoxicity and genotoxicity of human cells 2 AC, Sicard DM, de exposed in vitro to glyphosate. Biomedica Restrepo HG 25:335-345 IIA 5.10 Montgomery MP, Ka- mel 2008 Incident diabetes and pesticide exposure among 1 F, Saldana TM, Alavanja licensed pesticide applicators: Agricultural Health MC, Sandler DP Study, 1993-2003. Am J Epidemiol 167 (10):1235- 46. DOI: 10.1093/aje/kwn028.

Page 69 of 192

- 70 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Moon JM, Chun BJ 2010 Predicting acute complicated glyphosate intoxication 1 in the emergency department. Clin Toxicol (Phila) 48 (7):718-24. DOI: 10.3109/15563650.2010.488640.

IIA 5.10 Moon JM, Il Min Y, 2006 Can early hemodialysis affect the outcome of the 1 Chun BJ ingestion of glyphosate herbicide? Clinical Toxicology 44 (3):329-332. Doi 10.1080/15563650600584550.

IIA 5.10 Mose T, Kjaerstad MB, 2008 Placental passage of benzoic acid, caffeine, and 1 Mathiesen L, Nielsen JB, glyphosate in an ex vivo human perfusion system. Edelfors Sn, Knud- sen LE Journal of Toxicology and Environmental Health-Part a-Current Issues 71 (15):984-991. doi: 10.1080/01932690801934513.

IIA 5.10 Mueller U, Gorst J 2012 Comment on "Maternal and fetal exposure to 3 pesticides associated to genetically modified foods in Eastern Townships of Quebec, Canada" by A. Aris and S. Leblanc [Reprod. Toxicol. 31 (2011) 528-533]. Reproductive Toxicology 33 (3):401-402. DOI: 10.1016/j.reprotox.2012.01.012.

IIA 5.10 Mulet JM 2011 Letter to the Editor Regarding the Article by 3 K Paganelli et al. Chemical Research in Toxicology 24 (5):609-609. doi: 10.1021/tx200077h.

IIA 5.10 Multigner L, Ndong JR, 2008 [Environmental pollutants and prostate cancer: 1 Oliva A, Blanchet P epidemiological data]. Gynecol Obstet Fertil 36 (9):848-56. DOI: 10.1016/j.gyobfe.2008.07.005.

IIA 5.10 Nagami H, Nishigaki Y, 2005 Hospital-based survey of pesticide poisoning in 1 Matsushima S, Matsushita Japan, 1998--2002. Int J Occup Environ Health T, Asanuma S, Yajima N, 11 (2):180-4 Usuda M, Hirosawa M

IIA 5.10 Nakashima K, Yoshi- 2002 [Effects of pesticides on cytokines production by 1 mura T, Mori H, Ka- human peripheral blood mononuclear cells-- waguchi M, Adachi S, fenitrothion and glyphosate]. Chudoku Kenkyu Nakao T, Yamazaki F 15 (2):159-65

IIA 5.10 Naydenova E, Troev K, 2007 Synthesis, cytotoxicity and clastogenicity of novel 1 Topashka-Ancheva M, alpha-aminophosphonic acids. Amino Acids 33 Hagele G, Ivanov I, (4):695-702. DOI: 10.1007/s00726- Kril A 006-0459-y.

IIA 5.10 Ndong JR, Blanchet P, 2009 Pesticides and prostate cancer: epidemiological data. 1 Multigner L Bulletin Du Cancer 96 (2):171-180. doi: 10.1684/bdc.2008.0812. IIA 5.10 Negga R, Rudd DA, 2011 Exposure to Mn/Zn ethylene-bis- dithiocarbamate 3 (5.10) Also Davis NS, Justice AN, and glyphosate pesticides leads to 1 (8.16) listed Hatfield HE, Valente AL, neurodegeneration in Caenorhabditis elegans. under IIA Fields AS, Fitsanakis VA NeuroToxicology 32 (3):331-341. DOI: 8.16 10.1016/j.neuro.2011.02.002.

IIA 5.10 Neiva TJC, Morase ACR, 2010 In vitro effect of the herbicide glyphosate on human 2 Schwyzer R, Viture blood platelet aggregation and coagulation. Revista CDL, Rocha TRF, Fries Brasileira de Hematologia e Hemoterapia 32 (4):291- DM, Silva MA, Benedetti 294. DOI: AL 10.1590/S1516-84842010005000087.

Page 70 of 192

- 71 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Ngo MA, O'Malley M, 2010 Percutaneous absorption and exposure assessment 1 Maibach HI of pesticides. Journal of Applied Toxicology 30 (2):91-114. DOI: 10.1002/jat.1505.

IIA 5.10 Nielsen JB, Nielsen F, 2007 Defense against dermal exposures is only skin deep: 1 Sorensen JA significantly increased penetration through slightly damaged skin. Arch Dermatol Res 299 (9):423-31. DOI: 10.1007/s00403- 007-0788-z.

IIA 5.10 Nosanchuk JD, Ovalle 2001 Glyphosate inhibits melanization of Cryptococcus 1 R, Casadevall A neoformans and prolongs survival of mice after systemic infection. Jour- nal of Infectious Diseases 183 (7):1093-1099

IIA 5.10 Nougadère A, Reninger J- 2011 Chronic dietary risk characterization for pesticide 1 Also C, Volatier J-L, Leblanc J- residues: A ranking and scoring method integrating listed C agricultural uses and food contamination data. Food under IIA and Chemical Toxi- cology 49 (7):1484-1510. DOI: 6.10 10.1016/j.fct.2011.03.024. IIA 5.10 Okubo T, Miyazaki E, 2009 Acute respiratory distress due to PL granule- 1 Hate M, Ando M, Nu- induced pneumonitis which was difficult to reki S, Yoshimatsu T, Ito discriminate from toxic pneumonitis after exposure K, Kumamoto T to herbicide, Glyphosate. Japanese Journal of Chest Diseases [Nihon kyobu rins- ho] 68 (1):60-67

IIA 5.10 Oliveira AG, Telles LF, 2007 Effects of the herbicide Roundup on the epididymal 3 K Also Hess RA, Mahecha region of drakes Anas platyrhynchos. Reprod Toxicol listed GA, Oliveira CA 23 (2):182-91. DOI: 10.1016/j.reprotox.2006.11.004. under IIA 8.16

IIA 5.10 Orsi L, Delabre L, 2009 Occupational exposure to pesticides and lymphoid 1 Monnereau A, Delval P, neoplasms among men: results of a French case- Berthou C, Fenaux P, control study. Occupational and Environmental Marit G, Soubeyran P, Medicine 66 (5):291-298. DOI Huguet F, Milpied 10.1136/oem.2008.040972. N, Leporrier M, Hemon D, Troussard X, Clavel J

IIA 5.10 Paganelli A, Gnazzo V, 2010 Glyphosate-Based Herbicides Produce Teratogenic 3 E K Acosta H, Lopez SL, Effects on Vertebrates by Impairing Retinoic Acid Carrasco AE Signaling. Chem Res Toxicol 23 (10):1586-1595. DOI: 10.1021/tx1001749.

IIA 5.10 Pahwa P, Karunanaya- ke 2012 Multiple Myeloma and Exposure to Pesticides: A 1 CP, Dosman JA, Spinelli Canadian Case-Control Study. Journal of JJ, McDuffie HH, Agromedicine 17 (1):40-50. DOI: McLaughlin JR 10.1080/1059924x.2012.632339.

IIA 5.10 Palli E, Makris D, 2011 Rapture of the large intestine caused by severe oral 1 Diakaki C, Garoufalis G, glyphosate-surfactant intoxication. The American Zakynthinos E Journal of Emergency Medicine 29 (4):459-460. DOI: 10.1016/j.ajem.2010.12.002.

Page 71 of 192

- 72 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Palma G 2011 Letter to the Editor Regarding the Article by 3 K Paganelli et al. Chemical Research in Toxicology 24 (6):775-776. doi: 10.1021/tx200086y.

IIA 5.10 Park JH, Shin SD, Song 2012 Epidemiology and outcomes of poisoning- induced 1 KJ, Park CB, Ro YS, out-of-hospital cardiac arrest. Resusci- tation 83 Kwak YH (1):51-57. doi: 10.1016/j.resuscitation.2011.07.005.

IIA 5.10 Pastor S, Creus A, Parron 2003 Biomonitoring of four European populations 1 T, Cebulska- Wasilewska occupationally exposed to pesticides: use of A, Siffel C, Piperakis S, micronuclei as biomarkers. Mutagenesis 18 Marcos R (3):249-258

IIA 5.10 Paz-Y-Mino C, Sanchez 2007 Evaluation of DNA damage in an Ecuadorian 3 E K ME, Arevalo M, Munoz population exposed to glyphosate. Genetics and MJ, Witte T, De-La-Carrera Molecular Biology 30 (2):456-460 GO, Leone PE IIA 5.10 Pedroso JAR, da Silva 2010 The nephrologist as a consultant for acute poisoning: 1 CAM epidemiology of severe poisonings in the State of Rio Grande do Sul and techniques to enhance renal elimination. Jornal brasileiro de nefrologia : orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia 32 (4):340-8. doi: 10.1590/S0101- 28002010000400003. IIA 5.10 Peixoto F 2005 Comparative effects of the Roundup and 2 glyphosate on mitochondrial oxidative phosphorylation. Chemosphere 61 (8):1115- 1122. DOI 10.1016/j.chemosphere.2005.03.044.

IIA 5.10 Pelfrene A 2003 Glyphosate: Toxicology and Human Risk 1 Assessment. Environnement, Risques & Sante 2 (6):323-334 IIA 5.10 Peluso M, Munnia A, 1998 32P-postlabeling detection of DNA adducts in mice E K Bolognesi C, Parodi S treated with the herbicide Roundup. Environmental and Molecular Mutagenesis 31 (1):55-59. doi: 10.1002/(sici)1098- 2280(1998)31:1<55::aid-em8>3.0.co;2-a.

IIA 5.10 Penagos H, Ruepert C, 2004 Pesticide patch test series for the assessment of 2 Partanen T, Wesseling C allergic contact dermatitis among banana plantation workers in panama. Dermatitis 15 (3):137-45

IIA 5.10 Pham CH, Min J, Gu 2004 Pesticide induced toxicity and stress response in 2 MB bacterial cells. Bulletin of Environmental Contamination and Toxicology 72 (2):380- 386. DOI 10.1007/s00128-003-8845-6.

IIA 5.10 Pieniazek D, Bu- 2004 Comparison of the effect of Roundup Ultra 1 kowska B, Duda W 360 SL pesticide and its active compound glyphosate on human erythrocytes. Pesticide Biochemistry and Physiology 79 (2):58-63. DOI 10.1016/j.pestbp.2004.03.003.

IIA 5.10 Pieniazek D, Bu- 2003 [Glyphosate--a non-toxic pesticide?]. Med Pr 1 kowska B, Duda W 54 (6):579-83

Page 72 of 192

- 73 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Piesova E 2005 The effect of glyphosate on the frequency of 1 Also micronuclei in bovine lymphocytes in vitro. Acta listed Veterinaria-Beograd 55 (2-3):101-109 under IIA 8.16

IIA 5.10 Piesova E 2004 The Influence Of Different Treatment Length On the 1 Induction Of Micronuclei In Bovine Lymphocytes After Exposure To Glyphosate. Folia Veterinaria 48 (3):130-134

IIA 5.10 Poletta GL, Larriera A, 2009 Genotoxicity of the herbicide formulation Roundup 3 (8.16) K Also Kleinsorge E, Mudry MD (R) (glyphosate) in broad-snouted caiman (Caiman 2 (5.10) listed latirostris) evidenced by the Comet assay and the under IIA Micronucleus test. Mutation Research-Genetic 8.16 Toxicology and Environmental Mutagenesis 672 (2):95-102. DOI 10.1016/j.mrgentox.2008.10.007.

IIA 5.10 Potrebic O, Jovic- 2009 [Acute glyphosate-surfactant poisoning with 1 Stosic J, Vucinic S, neurological sequels and fatal outcome]. Voj- Tadic J, Radulac M nosanit Pregl 66 (9):758-62 IIA 5.10 Poulsen MS, Rytting E, 2009 Modeling placental transport: correlation of in vitro 1 Mose T, Knudsen LE BeWo cell permeability and ex vivo human placental perfusion. Toxicol In Vitro 23 (7):1380-6. DOI: 10.1016/j.tiv.2009.07.028.

IIA 5.10 Prasad S, Srivastava S, 2009 Clastogenic effects of glyphosate in bone marrow 3 K Singh M, Shukla Y cells of swiss albino mice. J Toxicol 2009:308985. DOI: 10.1155/2009/308985. IIA 5.10 Ptok M 2009 Dysphonia following glyphosate exposition. HNO 2 57 (11):1197-1201. DOI: 10.1007/s00106-009-1962-8. IIA 5.10 Quassinti L, Maccari E, 2009 Effects of paraquat and glyphosate on 1 Also Murri O, Bramucci M steroidogenesis in gonads of the frog Rana esculenta listed in vitro. Pesticide Biochemistry and Physiology 93 under IIA (2):91-95. DOI 8.16 10.1016/j.pestbp.2008.11.006.

IIA 5.10 Raipulis J, Toma M, 2009 Toxicity and genotoxicity testing of Roundup. 2 Also Balode M Proceedings of the Latvian Academy of Sciences. listed Section B. Natural, Exact, and Ap- plied Sciences. 63 under IIA (1-2):29-32. doi: 8.16 10.2478/v10046-009-0009-6.

IIA 5.10 Richard S, Moslemi S, 2005 Differential effects of glyphosate and roundup on 3 E K Sipahutar H, Benachour human placental cells and aromatase. Envi- ronmental N, Seralini GE Health Perspectives 113 (6):716-720

IIA 5.10 Roberts DM, Buckley NA, 2010 A prospective observational study of the clinical 1 Mohamed F, Edd- leston toxicology of glyphosate-containing herbicides in M, Goldstein DA, adults with acute self-poisoning. Clin Toxicol (Phila) Mehrsheikh A, Bleeke 48 (2):129-36. DOI: MS, Dawson AH 10.3109/15563650903476491.

IIA 5.10 Rodrigues HG, Penha- 2011 Effects of Roundup Pesticide on the Stability of 3 K Silva N, Araujo MFP, Human Erythrocyte Membranes and Micronuclei Nishijo H, Aversi- Frequency in Bone Marrow Cells of Swiss Mice. Ferreira TA Open Biology Journal (4):54- 59

Page 73 of 192

- 74 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Romano M, Romano R, 2012 Glyphosate impairs male offspring reproductive 3 K Santos L, Wisniewski development by disrupting gonadotropin expression. P, Campos D, de Souza P, Archives of Toxico- logy 86 (4):663-673. DOI: Viau P, Bernardi M, Nunes 10.1007/s00204- M, de Oliveira C 011-0788-9.

IIA 5.10 Romano RM, Romano 2010 Prepubertal exposure to commercial formulation of 3 E K MA, Bernardi MM, the herbicide glyphosate alters testosterone levels Furtado PV, Oliveira CA and testicular morphology. Arch Toxicol 84 (4):309- 17. DOI: 10.1007/s00204-009-0494-z.

IIA 5.10 Ruan QL, Ju JJ, Li YH, Liu 2009 Evaluation of pesticide toxicities with differing 1 R, Pu YP, Yin LH, Wang mechanisms using Caenorhabditis elegans. J Toxicol DY Environ Health A 72 (11):746-51. 10.1080/15287390902841532.

IIA 5.10 Sakazaki H, Ueno H, 2001 Immunotoxicological evaluation of environmental 1 Umetani R, Utsumi H, chemicals utilizing mouse lymphocyte mitogenesis Nakamuro K test. Journal of Health Science 47 (3):258-271

IIA 5.10 Saltmiras D, Bus JS, 2011 Letter to the Editor Regarding the Article by 3 E K Spanogle T, Hauswirth J, Paganelli et al. Chemical Research in Toxicology Tobia A, Hill S 24 (5):607-608. doi: 10.1021/tx100452k.

IIA 5.10 Salvagni J, Ternus RZ, 2011 Assessment of the genotoxic impact of pesticides 2 Also Fuentefria AM on farming communities in the countryside of listed Santa Catarina State, Brazil. Genetics and under IIA Molecular Biology 34 (1):122- 8.16 126

IIA 5.10 Sampogna RV, Cunard 2007 Roundup intoxication and a rationale for 1 R treatment. Clin Nephrol 68 (3):190-6 IIA 5.10 Sanin LH, Carrasquilla G, 2009 Regional Differences in Time to Pregnancy Among 2 Solomon KR, Cole DC, Fertile Women from Five Colombian Regions with Marshall EJP Different use of Glyphosate. Journal of Toxicology and Environmental Health-Part a-Current Issues 72 (15-16):949- 960. Doi 10.1080/15287390902929691.

IIA 5.10 Sathyanarayana S, Basso 2010 Maternal pesticide use and birth weight in the 1 O, Karr CJ, Lozano P, agricultural health study. J Agromedicine 15 Alavanja M, Sandler DP, (2):127-36. DOI: Hoppin JA 10.1080/10599241003622699.

IIA 5.10 Sato C, Kamijo Y, 2011 Aseptic meningitis in association with 1 Yoshimura K, Ide T glyphosate-surfactant herbicide poisoning. Clinical Toxicology 49 (2):118-120. doi: 10.3109/15563650.2011.552065.

IIA 5.10 Savitz DA, Arbuckle T, 1997 Male pesticide exposure and pregnancy outcome. E K Kaczor D, Curtis KM American Journal of Epidemiology 146 (12):1025-1036 IIA 5.10 Seok S-J, Park J-S, Hong 2011 Surfactant volume is an essential element in human 1 J-R, Gil H-W, Yang J-O, toxicity in acute glyphosate herbicide intoxication. Lee E-Y, Song H-Y, Clinical Toxicology 49 (10):892- Hong S-Y 899. DOI: 10.3109/15563650.2011.626422.

Page 74 of 192

- 75 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Settimi L, Davanzo F, 2007 Italian Program for Surveillance of Acute 1 Travaglia A, Locatelli C, Pesticide-Related Illnesses: cases identified in Cilento I, Volpe C, Russo 2005. Giornale italiano di medicina del lavoro ed A, Miceli G, Fracassi A, ergonomia 29 (3 Suppl):264-266 Maiozzi P, Marcello I, Sesan F, Urbani E

IIA 5.10 Shaham J, Kaufman Z, 2001 Frequency of sister-chromatid exchange 1 Gurvich R, Levi Z among greenhouse farmers exposed to pesticides. Mutat Res 491 (1-2):71-80 IIA 5.10 Shaner DL 2004 Herbicide safety relative to common targets in plants 1 and mammals. Pest Management Scien- ce 60 (1):17- 24. Doi 10.1002/Ps.782. IIA 5.10 Shoji R, Miyazaki T, 2003 Estimation of cytotoxicity to HEP-G2 cells of 1 Nishimiya T 255 environmental pollutants and water using QSAR (Quantitative Structure-Activity Relationship). Journal of Environmental Science and Health Part a- Toxic/Hazardous Substances & Environmental Engineering 38 (12):2807-2823. Doi 10.1081/Ese- 120025832.

IIA 5.10 Siddiqui S, Meghvansi 2012 Glyphosate, Alachor and Maleic Hydrazide have 2 M, Khan S Genotoxic Effect on Trigonella foenum- graecum L. Bulletin of Environmental Contamination and Toxicology 88 (5):659- 665. DOI: 10.1007/s00128-012-0570-6.

IIA 5.10 Sivikova K, Dianovsky 2006 Cytogenetic effect of technical glyphosate on 2 J cultivated bovine peripheral lymphocytes. Int J Hyg Environ Health 209 (1):15-20. DOI: 10.1016/j.ijheh.2005.07.005.

IIA 5.10 Slager RE, Poole JA, 2009 Rhinitis associated with pesticide exposure among 1 LeVan TD, Sandler DP, commercial pesticide applicators in the Agricultural Alavanja MCR, Hoppin Health Study. Occupational and Environmental JA Medicine 66 (11):718-724. DOI: 10.1136/oem.2008.041798.

IIA 5.10 Slager RE, Simpson SL, 2010 Rhinitis Associated with Pesticide Use Among 1 LeVan TD, Poole JA, Private Pesticide Applicators in the Agricultural Sandler DP, Hoppin JA Health Study. Journal of Toxico- logy and Environmental Health, Part A 73 (20):1382-1393. DOI: 10.1080/15287394.2010.497443.

IIA 5.10 Snelder DJ, Masipiquena 2008 Risk assessment of pesticide usage by smallholder 1 MD, de Snoo GR farmers in the Cagayan Valley (Philippines). Crop Protection 27 (3-5):747- 762. DOI 10.1016/j.cropro.2007.10.011.

IIA 5.10 Solomon K, R., Anadón 2007 Comparative Hazard Assessment of the Substances 1 Also A, Brain Richard A, Used for Production and Control of Coca and Poppy in listed Cerdeira Antonio L, Colombia. In Rational Environmental Management of under IIA Crossan Angus N, Agrochemicals. American Chemical Society. Chapter 8.16 Marshall J, Sanin L-H, 6. pp 87- Smith L 99. doi:10.1021/bk-2007-0966.ch006.

Page 75 of 192

- 76 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Solomon KR, Anadon A, 2007 Coca and poppy eradication in Colombia: 3 (8.16) Also Carrasquilla G, Cerdeira environmental and human health assessment of 1 (5.10) listed AL, Marshall J, Sanin LH aerially applied glyphosate. Rev Environ Con- tam under IIA Toxicol 190:43-125 8.16

IIA 5.10 Song H-Y, Kim Y-H, 2012 Cellular Toxicity of Surfactants Used as 1 Seok S-J, Gil H-W, Yang Herbicide Additives. Journal of Korean J-O, Lee E-Y, Hong S-Y Medical Science 27 (1):3-9. DOI: 10.3346/jkms.2012.27.1.3.

IIA 5.10 Soso AB, Barcellos LJG, 2007 Chronic exposure to sub-lethal concentration 3 E K Also Ranzani-Paiva MJ, of a glyphosate-based herbicide alters hormone listed Kreutz LC, Quevedo profiles and affects reproduction of female Jundia under IIA RM, Anziliero D, Lima (Rhamdia quelen). Environmental To- xicology and 8.16 M, da Silva LB, Ritter F, Pharmacology 23 (3):308-313. DOI Bedin AC, Finco JA 10.1016/j.etap.2006.11.008.

IIA 5.10 Steffens W, Ptok M 2010 [Glyphosate exposure]. HNO 58 (7):733-5. DOI: 1 10.1007/s00106-010-2133-7. IIA 5.10 Stella J, Ryan M 2004 Glyphosate herbicide formulation: a potentially lethal 1 ingestion. Emerg Med Australas 16 (3):235-9. DOI: 10.1111/j.1742- 6723.2004.00593.x.

IIA 5.10 Swaen GMH, van 2004 Cancer mortality in a cohort of licensed herbicide 1 Amelsvoort LGPM, applicators. International Archives of Occupational Slangen JJM, Mohren and Environmental Health 77 (4):293-295. DOI DCL 10.1007/s00420-004-0503- 8.

IIA 5.10 Taponen J, Pulkkanen P, 2002 Grazing On Pastures Treated With Glyphosate: 1 Saastamoinen I, Influence On Bovine Reproduction Suomen Saloniemi H Elainlaakarilehti 108 (6):332-336 IIA 5.10 Valcin M, Henneberger 2007 Chronic bronchitis among nonsmoking farm women 1 PK, Kullman GJ, Um- bach in the agricultural health study. J Oc- cup Environ DM, London SJ, Alavanja Med 49 (5):574-83. DOI: MC, Sandler DP, Hoppin 10.1097/JOM.0b013e3180577768. JA

IIA 5.10 Vasiluk L, Pinto LJ, 2005 Oral bioavailability of glyphosate: Studies using 1 Moore MM two intestinal cell lines. Environmental Toxicology and Chemistry 24 (1):153-160 IIA 5.10 Vigfusson NV, Vyse 1980 The effect of the pesticides Dexon, Captan and E K ER Roundup on sister chromatid exchanges in human lymphocytes in-vitro. Mutation Re- search 79 (1):53- 57. doi: 10.1016/0165- 1218(80)90147-0.

IIA 5.10 Vlastos D, Stivaktakis 2006 Pesticide exposure and genotoxicity correlations 1 P, Matthopoulos DP within a Greek farmers group. International Journal of Environmental Analy- tical Chemistry 86 (3- 4):215-223. Doi 10.1080/03067310500247710.

IIA 5.10 Walsh LP, McCormick C, 2000 Roundup inhibits steroidogenesis by disrupting E K Martin C, Stocco DM steroidogenic acute regulatory (StAR) protein expression. Environmental Health Perspectives 108 (8):769-776. doi: 10.1289/ehp.00108769.

Page 76 of 192

- 77 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Wang G, Fan XN, Tan 2011 Parkinsonism after chronic occupational 2 YY, Cheng Q, Chen SD exposure to glyphosate. Parkinsonism & Related Disorders 17 (6):486-487. doi: 10.1016/j.parkreldis.2011.02.003.

IIA 5.10 Weichenthal S, Moase 2010 A review of pesticide exposure and cancer incidence 1 C, Chan P in the Agricultural Health Study cohort. Environ Health Perspect 118 (8):1117- 25. DOI: 10.1289/ehp.0901731.

IIA 5.10 Weng SF, Hung DZ, Hu 2008 Rhabdomyolysis from an intramuscular injection 1 SY, Tsan YT, Wang of glyphosate-surfactant herbicide. Clin Toxicol LM (Phila) 46 (9):890-1. DOI: 10.1080/15563650802286731.

IIA 5.10 Wester RC, Quan D, 2005 Percutaneous Absorption of Hazardous 1 Maibach HI, Wester Chemicals from Fabric into and Through Human RM Skin. In Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods. Boca Raton, FL. Taylor and Francis Group, LLC. Chapter 22. pp 303-310.

IIA 5.10 Williams AL, Watson 2012 Developmental and Reproductive Outcomes in 1 RE, DeSesso JM Humans and Animals After Glyphosate Exposure: A Critical Analysis. Journal of To- xicology and Environmental Health, Part B 15 (1):39-96. DOI: 10.1080/10937404.2012.632361.

IIA 5.10 Williams GM, Kroes R, 2000 Safety evaluation and risk assessment of the E K Munro IC herbicide Roundup and its active ingredient, glyphosate, for humans. Regulatory Toxicolo- gy and Pharmacology 31 (2):117-165. doi: 10.1006/rtph.1999.1371.

IIA 5.10 Wu JY, Chang SS, 2006 Parenteral glyphosate-surfactant herbicide 1 Tseng CP, Deng JF, intoxication. Am J Emerg Med 24 (4):504-6. DOI: Lee CC 10.1016/j.ajem.2005.12.002. IIA 5.10 Xie LT, Thrippleton K, 2005 Evaluation of estrogenic activities of aquatic 1 Also Irwin MA, Siemering GS, herbicides and surfactants using an rainbow trout listed Mekebri A, Crane D, Berry vitellogenin assay. Toxicological Scien- ces 87 under IIA K, Schlenk D (2):391-398. DOI 8.16 10.1093/toxsci/kfi249.

IIA 5.10 You YH, Jung WJ, Lee 2012 Effect of intravenous fat emulsion therapy on 1 MJ glyphosate-surfactant–induced cardiovascular collapse. The American Journal of Emergency Medicine. DOI: 10.1016/j.ajem.2011.06.042.

IIA 5.10 Yousef MI, Salem MH, 1995 Toxic effects of Carbofuran and Glyphosate on semen E K Ibrahim HZ, Helmi S, characteristics in rabbits. Journal of Environmental Seehy MA, Bertheus- sen Science and Health Part B- Pesticides Food K Contaminants and Agricultural Wastes 30 (4):513- 534. doi: 10.1080/03601239509372951.

IIA 5.10 Yue Y, Zhang Y, Zhou 2008 In vitro study on the binding of herbicide glyphosate 1 L, Qin J, Chen X to human serum albumin by optical spectroscopy and molecular modeling. J Pho- tochem Photobiol B 90 (1):26-32. DOI: 10.1016/j.jphotobiol.2007.10.003.

Page 77 of 192

- 78 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 5.10 Zaghi D, Wester RC, 2008 Pesticide percutaneous absorption and 1 Maibach HI decontamination. In Marzulli and Maibach's Dermatotoxicology, 7th Edition, edited by H. Zhai, K. P. Wilhelm and H. I. Maibach. Boca Raton, FL. Taylor & Francis Group. Chapter 36. pp 317-325. doi: 10.1201/9781420009774.ch36.

IIA 5.10 Zhai H, Chan HP, Hui 2008 Skin decontamination of glyphosate from human 1 X, Maibach HI skin in vitro. Food Chem Toxicol 46 (6):2258-60. DOI: 10.1016/j.fct.2008.03.001. IIA 5.10 Zhou Y, Kastenberg 2006 Quantification of changes in chemical pesticide human 1 WE health risk following the introduction of Bt cotton and herbicide-tolerant soybean: A case study. Human and Ecological Risk As- sessment 12 (5):871-887. Doi 10.1080/10807030600826920.

Page 78 of 192

- 79 - Glyphosate –List of tests and studies Toxicology and metabolism

Table 3. Supporting publications and documents Annex Author(s) Year Title point/ Citation reference number

IIA 5.10 Acquavella 1999 Letter to the Editor re: “A Case–Control Study of Non-Hodgkin Lymphoma and Exposureto Pesticides”. IIA 5.10 AFSSA (En) 2009 Notice from the French Agency for Food Safety regarding glyphosate and phytopharmaceutical preparations based on this active substance, Afssa – submission no. 2008-SA-0034 – Glyphosate

IIA 5.10 AFSSA (Fr) 2009 Avis de l'Agence française de sécurité sanitaire des aliments relatif au glyphosate et aux préparations phytopharmaceutiques à base de cette substance active, Afssa – saisine n°2008-SA-0034 - Glyphosate

IIA 5.10 Amouroux I., Pesando D., Noel H., 1999 Mechanisms of cytotoxicity by cosmetic ingredients Girard J-P. in sea urchin eggs. Archives of Environmental Contamination & Toxicology 36: 28-37.

IIA 5.10 Blair A., Zahm S.H. 1993 Patterns of pesticide use among farmers: implications for epidemiologic research. Epidemiology 4:55-62. IIA 5.10 Bleeke, M.S., Kurtzweil, M.L. and 2010 Dietary Exposure Assessment of Saltmiras, D.A. Polyoxyethylenealkylamines (POEA) Surfactants IIA 5.10 BfR 2009 BfR-Bewertung der Studie “Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines” vom 06.08.2009 IIA 5.10 BVL 2010 Glyphosate - Comments from Germany on the paper by Paganelli, A. et al. (2010): “Glyphosate-based Herbicides Produce Teratogenic Effects on Vertebrates by Impairing Retinoic Acid Signaling” IIA 5.10 Carr, K.H. and Bleeke, M.S. 2012 Process Description for Identification, Review, and Also listed Categorization of Scientific Literature Concerning under Glyphosate and AMPA Side-Effects on Health, the IIA 6.10, Environment, and Non-Target Species IIA 7.13 IIA 8.16

IIA 5.10 EFSA 2012 Letter to Corporate Europe Observatory, Earth Open Source, from EFSA Executive Director, Catherine Geslain-Lanéelle IIA 5.10 European Commission 2011 Standing Committee on the Food Chain and Animal Health, Section Phytopharmaceuticals – Plant Protection Products – Legislation – 22-23 November 2010. Summary Report.

IIA 5.10 Farmer DR, Lash TL, Acquavella JF 2005 Glyphosate Results Revisited. Environmental Health Perspectives 113(6): A365-A366

Page 79 of 192

- 80 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title point/ Citation reference number

IIA 5.10 French Committee for the Study of 2005 Enquiry into the referral of the Committee for the Toxicity (En) Study of Toxicity by the DGAL regarding the article “Differential effects of glyphosate and Roundup on human placental cells and aromatase.” Richard S., Moslemi S., Sipahutar H., Benachour N., Seralani G.E., Environ. Health Perspect., 2005 (in the press; online 24 February 2005)

IIA 5.10 French Commission d’Etude de la Instruction de la saisine de la Commission d’étude Toxicité: de la toxicité par ls DGAL sur l’article “Differential effects of glyphosate and Roundup on human placental cells and aromatase.” Richard S., Moslemi S., Sipahutar H., Benachour N., Seralani G.E., Environ. Health Perspect., 2005 (sous presse; online 24 February 2005)

IIA 5.10 Holson 1990 A Developmental Toxicity Study of MON 0818 in Rats, Final Report, Sponsor No.: WI-89-388

IIA 5.10 Kelce, W.R., Lamb, J.C. and 2010 A Critique of “Prepubertal Exposure to DeSesso, J.M. Commercial Formulation of the Herbicide Glyphosate Alters Testosterone Levels and Testicular Morphology” by Romano et al.

IIA 5.10 Kier L.D. 2010 Analysis of Bolognesi et al. (2009) J. Tox. Env. Health 72, 986-997 IIA 5.10 Klimisch H.J., Andreae M, Tillmann 1997 A systematic approach for evaluating the quality of Also listed U experimental toxicological and ecotoxicological under data. Regulatory Toxicology and Pharmacology 25 IIA 6.10, (1):1-5 IIA 7.13 IIA 8.16

IIA 5.10 Knapp, J.F. 2007 A Reproduction/Developmental Toxicity Screening Study of MON 0818 in Rats. Study No.: WIL-50282

IIA 5.10 Knapp, J.F. 2008 A Combined 28-Day Repeated Dose Oral (Dietary) Toxicity Study with the Reproduction/Developmental Toxicity Screening Test of MON 8109 and MON 0818 in Rats

IIA 5.10 National Cancer Institure 2012 TM What You Need To Know About Non- Hodgkin Lymphoma IIA 5.10 Saltmiras, D.A. and Tobia, A. 2012 No Evlidence of Endocrine Disruption by Glyphosate in Hershberger and Uterotrophic Assays. Abstract PS 2198. The Toxicologist (supplement to Toxicological Scien- ces)126(1): 474.

Page 80 of 192

- 81 - Glyphosate –List of tests and studies Toxicology and metabolism Annex Author(s) Year Title point/ Citation reference number

IIA 5.10 US EPA 2009 Final List of Initial Pesticide Active Ingredients and Pesticide Inert Ingredients to be Screened Under the Federal Food, Drug, and Cosmetic Act. Federal Register /Vol. 74, No. 71 /Wednesday, April 15, 2009 /Notices, 17579- 17585

IIA 5.10 Williams, A.L., Kimmel, G.L., 2012b Review and Evaluation of the Rabbit Kimmel, C.A. and DeSesso, J.M. Developmental Toxicity Database on Glyphosate, with Particular Attention to Cardiac Malformations

Page 81 of 192

- 82 - Glyphosate –List of tests and studies Residue data

2. Residue

2.1 Residue – Active Substance

Year Annex Title Owner Bayer Document Number point/ Source -Company name reference Report number No. Date GLP status, published or not

1991* IIA 6.1.1 Storage stability of Glyphosate residues in BAY M-644183-01-2 crop commodities れ:ubJz*゛ Bä2・龽・n, USA Study No.: MSL- 10843 Report No.: RIP95-01332 Date: 1991-06-01 GLP: yes unpublished

1988* IIA 6.1.1 Storage stability of Glyphosate and AMPA in BAY M-645906-01-2 swine tissues, dairy cow tissues and milk, laying hen tissues and eggs 4ehみkJョj 龾ゕ・dc8ö, USA Study No.: MSL 7515 Report No.: RIP95-01253 Date: 1988-02-16 GLP:: no unpublished 1989* IIA 6.1.1 Storage stability validation for ICIA0224 in SYN raw agricultural commodities. F9yjä.k・z säeilj5J Qi:i, UK Study No.: WRC 89-22 Report No.: RIP95-00028 Date: 1989-04-30 GLP:: yes unpublished

1995* IIA 6.1.1 Glyphosate-Trimesium: Storage Stability of SYN Residue of N-(phosphonomethyl)glycine (PMG) and Trimethylsulphonium Cation (TMS) (both derived from Glyphosate- trimesium) in Processed Fractions of Winter Wheat and Common Oats Tzpä?e じ4fqeä?tJ$゗ät Study No.: 93JH124 Report No.: RIP96-00003 Date: 1995-12-20 GLP:: yes unpublished

1987* IIA 6.1.1, Magnitude of SC-0224 Residues in Meat and Milk SYN Also lz`FdIzf ゕ1゗lic?? ゕ2eo5龿4 filed Study No.: RRC 87-44 under Report No.: RIP95-00024 IIA 6.4 Date: 1987-07-31 GLP:: no unpublished

Page 82 of 192

- 83 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document point/ Source -Company name Number referenc Report e No. Date number GLP status, published or not

1987* IIA 6.1.1, Magnitude of SC-0224 Residues in Eggs and SYN Also filed Poultry under Füz)/zI- ゗la?R4z: ゛_ゕ゜龽e8 IIA 6.4 Study No.: RRC 87-43 Report No.: RIP95-00025 Date: 1987-07-31 GLP: no unpublished

1996a IIA Determination of glyphosate in soybean raw CHE 6.1.1/01 agricultural commodities (RAC) stability report $v§$pk2U:t jErä PjacJ?p? ar3., USA Study No.: 91210 Report No.: 455 GLY Date: 1996-08-21 GLP: yes unpublished

1996b IIA Determination of glyphosate in pasture CHE 6.1.1/02 grasses stability report g3:k゛しt1pく l`äZ aJFatc8ä -ョz., USA Study No.: 91212 Report No.: 456 GLY Date: 1996-08-21 GLP: yes unpublished

1995 IIA Storage Stability of Glyphosate and AMPA in CHE 6.1.1/03 Wheat Grain and Straw and in Rye Grain and Straw BゕB A぀Da9a:acjj龾しイ. Switzerland Study No.: 303614 Report No.: 325 GLY Date: 1995-11-30 GLP: yes unpublished

1997 IIA Determination of the Storage Stability of CHE 6.1.1/04 Glyphosate in Beans, Oilseed Rape and Linseed öl-Jt/くi SäJ?t゜J!h, Germany Study No.: IF-94/13882-00 Report No.: 394 GLY Date: 1997-02-13 GLP: yes unpublished

2010 IIA Storage stability of residues of Glyphosate FSG 6.1.1/05 and AMPA in various plant materials `ürpTxtJ -Ä, ゜aa・jF OZS 龾UÜ・, Germany Report No.: FCS-0707 Date: 2010-03-11 GLP: yes unpublished

Page 83 of 192

- 84 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document Number point/ Source -Company name reference Report number No. Date GLP status, published or not

2012 IIA Storage stability of glyphosate and AMPA on BAY M-646734-01-2 6.1.1/06 citrus fruit Jc/れkdv0 ゕ&65e87 qlo:Ty!§&c3i? /zcP?qJ・ juE?e0q・h lz`Rz_, USA Report No.: MSL0023608 Date: 2012-02-01 GLP: yes unpublished 1975* IIA 6.2.1 The metabolism of CP 67573 by citrus. BAY M-649162-01-2 みpü1_Jz: ゕy8゘・ä・, USA Study No.: FR328. Report No.: RIP95-01194. Date: 1975-06-01 GLP: no unpublished

1976* IIA 6.2.1 Absorption, translocation and metabolism of BAY M-649322-01-2 Roundup herbicide in walnut, almond and pecan trees. 2くlねJäx9 g぀oe*ゕg, USA Study No.: FR403. Report No.: RIP95-01196. Date: 1976-04-01 GLP: no unpublished

1974* IIA 6.2.1 CP 67573 residue and metabolism Part 23: BAY M-649026-01-2 The metabolism of CP 67573 in apple trees. れ2xäphJj Bqd゗*?o, USA Study No.: FR342. Report No.: RIP95-01190. Date: 1974-10-29 GLP: no unpublished

1974* IIA 6.2.1 CP 67573 residue and metabolism Part 20: The BAY M-649025-01-2 metabolism of CP 67573 in grape plants ゜öヸqJ?iö 1龿8eゕ・ョ, USA Study No.: FR335. Report No.: RIP95-01191. Date: 1974-06-01 GLP: no unpublished

1975* IIA 6.2.1 CP 67573 residue and metabolism Part 26: The BAY M-649161-01-2 metabolism of CP67573 in potato plants. ゜ögヸuJ?j *龼Bvc1ö, USA Study No.: FR376. Report No.: RIP95-01193 Date: 1975-03-01 GLP: no unpublished

Page 84 of 192

- 85 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document Number point/ Source -Company name reference Report number No. Date GLP status, published or not

1973* IIA 6.2.1 CP 67573, Residue and Metabolism Part 10: BAY M-648850-01-2 The Metabolism of CP 67573 in Soybeans, Cotton, Wheat, and Corn. れ_4:J?oョ・bc6öB龿, USA Study No.: FR304. Report No.: RIP96-00099 Date: 1973-07-02 GLP: no unpublished

1974* IIA 6.2.1 CP 67573 residue and metabolism Part 22: BAY M-649027-01-2 The metabolism of N- phosphonomethy1g1ycine in barley, oats, rice and sorghum. 3J2juみkä u0dゕö&ä, USA Study No.: FR341. Report No.: RIP95-01189 Date: 1974-12-01 GLP: no unpublished

1976* IIA 6.2.1 CP 67573 residue and metabolism Part 29: The BAY M-649164-01-2 metabolism of CP 67573 in sugar beets. ヸくe:dJq5 B゜ehョ§゗. USA Study No.: FR394. Report No.: RIP95-01195 Date: 1976-03-01 GLP: no unpublished

1975* IIA 6.2.1 Glyphosate residue and metabolism studies in BAY M-651454-01-2 sugarcane and soils. れ12J§xäj B75&u?u, USA Report No.: RD93. Report No: RIP95-01l98 Date: 1976-03-01 GLP: no unpublished

1975* IIA 6.2.1 CP 67573 residue and metabolism Part 24: The BAY M-649024-01-2 metabolism of CP 67573 in coffee plants. ヸ$älüJ・8 B$龽üco*, USA Study No.: FR344. Report No.: RIP95-01192 Date: 1975-02-01 GLP: no unpublished 1976* IIA 6.2.1 The metabolism of Glyphosate in pasture BAY M-649321-01-2 crops. み6:bJzョx bB&ョe$o, USA Study No.: FR404. Report NO.: RIP95-01197 Date: 1976-05-18 GLP: no unpublished

Page 85 of 192

- 86 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document Number point/ Source -Company name reference Report number No. Date GLP status, published or not

1995* IIA 6.2.1 Nature of Glyphosate Residues in Corn Plants BAY M-650178-01-2 Which are Tolerant to Roundup Herbicide. み7qJic12 Rc゛&2x*, USA Study No.: MSL-14018. Report No.: RIP97-00618 Date: 1995-06-12 GLP: yes unpublished

1994* IIA 6.2.1 Nature of Glyphosate Residues in Roundup BAY M-650452-01-2 Herbicide Tolerant Canola. みüJn*ehj ゕg5龽xc8, USA Study No.: MSL-13318 Report No.: RIP98-00118 Date: 1994-06- 08 GLP: yes unpublished

1997* IIA 6.2.1 Nature of G1yphosate Residues in Cotton BAY M-650177-01-2 Plants Tolerant to Roundup Herbicide. 4Jね2?0ix ゕ9?2゗1゛, USA Study No.: MSL-14113. Report No.: RIP97-00619 Date: 1997-03-25 GLP: yes unpublished

1994* IIA 6.2.1 Nature of Glyphosate Residues in Soybeans BAY M-650176-01-2 Tolerant to Roundup Herbicide. れxeョ:§*J &?6゛Bu_, USA Study No.: MSL-13520 Report No.: RIP98-00117 Date: 1994-07-07 GLP: yes unpublished

1985* IIA 6.2.1 The nature of the residue of SC-0224 in citrus. SYN Pixr(c)c Rä龼z゛:e: Company Study No.: PMS-158. Report No.: RIP95-00011. Date: 1987-04-20 GLP: yes unpublished

1990* IIA 6.2.1 ICIA0224: Uptake and metabolism in grape SYN vines. fB- ÖIüezt?Jn゜぀c: Study No.: 88JH388. Report No.: RIP95-00017. Date: 1990- 02-28 GLP: yes unpublished

Page 86 of 192

- 87 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report number No. Date GLP status, published or not

1991* IIA 6.2.1 Glyphosate-trimesium: Uptake and SYN metabolism in USA grape vines. ゕr` ョzc龿?:Jしく(d/z Study No.: 89JH105. Report No.: RIP95-00012. Date: 1991-11-15 GLP: yes unpublished

1992* IIA 6.2.1 [14C-Anion] ICIA0224: Nature of the SYN residue: Soybeans. )(ゕ äl??JÖ&` )8?. Study No.: PMS 304. Report No.:RIP95-00015. Date: 1992-05-29 GLP: yes unpublished

1989* IIA 6.2.1 lClA0224: Metabolism on wheat following a SYN preharvest foliar spray. )B` p)ed?tzeHh぀:J Study No.: 88JH358. Report No.: RIP95-00014. Date: 1989- 12-06 GLP: yes unpublished 1988* IIA 6.2.2 Metabolism study of synthetic 13C/14C- BAY M-650618-01-2 labeled Glyphosate and Aminomethylphosphonic acid in laying hens. Part I. zeid4ダ?: Eüh-cq?zj`jJ し(jzc&?. f2e. Study No.: MSL 7591. Report No.: RIP95-01205. Date: 1987-11-13 GLP: yes unpublished

1988* IIA 6.2.2 Metabolism study of synthetic 13C/14C- BAY M-650617-01-2 labeled Glyphosate and Aminomethylphosphonic acid in laying hens. Part II. ねョz/hkJö ゘Rk7c3p, USA Study No.: MSL 7420. Report No.: RIP95- 01206. Date: 1988-02-01 GLP: yes unpublished

Page 87 of 192

- 88 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report number No. Date GLP status, published or not

1994* IIA 6.2.2 (14C-G1yphosate): Distribution, metabolism CHE and excretion following repeated oral administration to the laying hen. clbyAz?t T3a9`7, UK Study No.: . 676/8-1011 Report No.: RIP95-01208. Date: 1994-11-07 GLP: yes unpublished

1994* IIA 6.2.2 [14C-PMG] Glyphosate-trimesium: Nature of SYN the Residue in Tissues and Eggs of Laying Hens. E?3?ze ,Ö9 F(gä:J$* Study No.: PMS 379. Report No.: RIP95-00020 Date: 1994-02-28 GLP: yes unpublished

1988 IIA 6.2.3 Metabolism study of synthetic 13C/14C- BAY M-650451-01-2 labeled Glyphosate and Aminomethylphosphonic acid in lactating goats. Part I. e?jくイä:9 Tく-4cJ?ü?j`t Y&!??.cl _a,` Study No.: MSL 7586. Report No.: RIP95-01203. Date: 1987-11-13 GLP: yes unpublished

1988* IIA 6.2.3 Metabolism study of synthetic 13C/14C- BAY M-650619-01-2 labeled Glyphosate and Aminomethylphosphonic acid in lactating goats. Part II. ヸb3Jc96: Bョc3g゗0, USA Study No.: MSL 7458 Report No.: RIP95-01204 Date: 1988-02-01 GLP: yes unpublished 1994* IIA 6.2.3 (14C-Glyphosate): Absorption, distribution, CHE metabolism and excretion following repeated oral administration to the dairy goat. e8Näjcik Z!9övz, UK Study No.: 676/9-1011 Report No.: RIP95-01207 Date: 1994-11-07 GLP: yes unpublished

Page 88 of 192

- 89 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report number No. Date GLP status, published or not

1994* IIA .6.2.3 The Nature of Residues of Orally SYN Administered [Phosphonomethylene-14C glyphosate-trimesium in Goat Tissues and Milk. Läea0§e Ud. Products Study No.: PMS 378. Report No.: RIP95-00022. Date: 1994-03-14 GLP: yes unpublished

2012 IIA Determination of residues of glyphosate and GTF 6.3.1/01 AMPA after one application of MON 52276 in potatoes (outdoor) at 4 sites in France, Germany and Italy 2011 g/T!br7J ヌnyJcyäz!zj ?(äzF_/ ÜÄ龾p Study No.: S11-00258 Date: 08 March 2012 GLP: yes unpublished 2012 IIA Determination of residues of glyphosate and GTF 6.3.2/01 AMPA after one application of MON 52276 in carrots (outdoor) at 4 sites in France, Spain and Poland 2011 l゛JT5(v) hJ?aVョ`jcdz !jPc゛zc イ゘nÄ Study No.: S11-00259 Date: 28 February 2012 GLP: yes unpublished 2012 IIA Determination of residues of glyphosate and GTF 6.3.3/01 AMPA after one application of MON 52276 in bulb onions (outdoor) at 4 sites in France, Spain and Bulgaria 2011 nf1:qJT! fg?t?äダョJ$ä P`h:eää ゘Q9K Study No.: S11-00260 Date: 28 February 2012 GLP: yes unpublished

2012 IIA Determination of residues of glyphosate and GTF 6.3.4/01 AMPA after one application of MON 52276 in tomato (outdoor) at 2 sites in Hungary and Germany 2011 $!(/JT3p `kD3Jala*aa Fä(ylez O龿dY Study No.: S11-00267 Date: 28 February 2012 GLP: yes unpublished

Page 89 of 192

- 90 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report number No. Date GLP status, published or not

2012 IIA Determination of residues of glyphosate and GTF 6.3.5/01 AMPA after one application of MON 52276 in cucumber and zucchini (outdoor) at 3 sites in Italy, France and Germany 2011 50(T(j9J oInJzz?X/a* Fz`$:zä しg぀Q Study No.: S11-00261 Date: 28 February 2012 GLP: yes unpublished 2012 IIA Determination of residues of glyphosate and GTF 6.3.6/01 AMPA after one application of MON 52276 in cauliflower (outdoor) at 4 sites in France, Hungary, Bulgaria and Italy 2011 Z0))$゜lJ じIJhp6?:aää l?zP?f9 QY龿$ Study No.: S11-00263 Date: 28 February 2012 GLP: yes unpublished

2012 IIA Determination of residues of glyphosate and GTF 6.3.7/01 AMPA after one application of MON 52276 in head cabbage (outdoor) at 4 sites in Hungary, France (North), Spain and Bulgaria 2011 üör4T-lJ Jtc?GüIョäb? Fz(7t?e QU龿g Study: S11-00262 Date: 08 March 2012 GLP: yes unpublished 2012 IIA Determination of residues of glyphosate and GTF 6.3.8/01 AMPA after one application of MON 52276 in leaf and head lettuce (outdoor) at 4 sites in France, Spain, UK and Germany 2011 T・Iv`j6J ?゜?HdfョJjaz P!?ckta 龼qÜÄ Study No.: S11-00264 Date: 08 March 2012 GLP: yes unpublished 2012 IIA Determination of residues of glyphosate and GTF 6.3.9/01 AMPA after one application of MON 52276 in leek (outdoor) at 4 sites in France, United Kingdom, Bulgaria and Italy 2011 ü゜L)8-lJ じdfä:zbJcva FuezI/ä くし龼ヌ Study No.: S11-00265 Date: 28 February 2012 GLP: yes unpublished

2012 IIA Determination of residues of glyphosate and GTF 6.3.10/01 AMPA after one application of MON 52276 in sugar beet (outdoor) at 2 sites in Spain and Italy 2011 y)§JZ)ョj !J3??Üpke:? )klääPz Nく V゘ Study No.: S11-00266 Date: 08 March 2012 GLP: yes unpublished

Page 90 of 192

- 91 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document Number point/ Source -Company name reference Report number No. Date GLP status, published or not 1987* IIA 6.4 Residue determination of Glyphosate and BAY M-651048-01-2 AMPA in laying hen tissues and eggs following a 28-day feeding study. く/ヸ*Je$§ ゘cョ2ゕく7, USA Study No.: MSL 6676 Report No.: RIP95-01252 Date: 1987-11-02 GLP: no unpublished

1987* IIA 6.4 Magnitude of SC-0224 Residues in Eggs and SYN filed Poultry under PcI:yI(a R:ä*c぀z: B3぀hz4k IIA 6.1.1 Study No.: RRC 87-43 Report No.: RIP95-00025 Date: 1987-07-31 GLP: no unpublished

1987* IIA 6.4 Residue determination of Glyphosate and BAY M-650790-01-2 AMPA in dairy cow tissues and milk following a 28-day feeding study. nJ1l5れ9ä 4n70R゗c, USA Study No.: MSL 6729 Report No.: RIP95-01250 Date: 1987-09-29 GLP: no unpublished 1987* IIA 6.4, Magnitude of SC-0224 Residues in Meat and Milk SYN filed Pä4ra)/- Bd?t龽/e? 1vゕö゗qä under Study No.: RRC 87-44 IIA 6.1.1 Report No.: RIP95-00024 Date: 1987-07-31 GLP:: no unpublished

1987* IIA 6.4 Residue determination of Glyphosate and BAY M-651049-01-2 AMPA in swine tissues following a 28-day feeding study. ヸvくxJz5: ゕ&?ョ゜6k, USA Study no.: MSL 6627. Reference No.: RIP95-0125l. Date: 1987-09-28 GLP: no unpublished 1982* IIA 6.4 Glyphosate residues in grass, hay and silage BAY M-650795-01-2 following preharvest application of Roundup in the United Kingdom. ね゜y$Je8l $・c$7R぀, USA Study no.: MLL 30.080 Reference no. RIP95-01242. Date: 1982-05-15 GLP: no unpublished

Page 91 of 192

- 92 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document Number point/ Source -Company name reference Report number No. Date GLP status, published or not

1982* IIA 6.4 Glyphosate residues in ray grass, hay and BAY M-650794-01-2 silage following preharvest application of Roundup in France. ヸ0dJ?$3/ öゕ぀゜?y・, USA Study no.: MLL 30.082 Reference no. RIP95-01245 Date: 1982-09-15 GLP: no unpublished

1983* IIA 6.4 Residue analysis for glyphosate and AMPA in BAY M-650793-01-2 grass and silage following topical treatment with Roundup herbicide in Holland and Denmark 1982 trials. pJä/ね327 hR§゘cd8, USA Study no.: MLL 30.101 Reference no. RIP95-01264 Date: 1983-03-15 GLP: no unpublished

1979* IIA 6.4 Glyphosate residue in grass following BAY M-650796-01-2 Roundup application in the UK. 1pみ5dJz/ Bub*龽z_, USA Study no.: MLL 30.029 Reference no. RIP95-01228 Date: 1979-06-06 GLP: no unpublished

1984* IIA 6.4 Glyphosate and AMPA residues in grass, hay BAY M-650792-01-2 and silage following Roundup herbicide preharvest application in Germany and Finland trials. ねgJくghcj §6・B゗?く, USA Study no.: MLL 30.132 Reference no. RIP95-01273 Date: 1984-09-15 GLP: no unpublished 1984* IIA 6.4 Glyphosate and AMPA residues in ray grass, BAY M-650791-01-2 hay and silage following Roundup herbicide preharvest application in France -1982 and 1983 trials. 2l6ヸ9Jäu z89ゕョ龿2, USA Study no.: MLL 30.116 Reference no. RIP95-01271 Date: 1984-02-15 GLP: no unpublished

Page 92 of 192

- 93 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document Number point/ Source -Company name reference Report number No. Date GLP status, published or not

1988* IIA 6.4 Residue determination of Glyphosate and BAY M-650615-01-2 Aminomethylphosphonic acid in various crops following different Roundup or Glyphosate based formulations applications. 1978-1987 trial period みv9c5J゛j Bc5゘゛ö3, USA Study no.: MLL 30.206 Reference no. RIP95-01281 Date: 1988-04-15 GLP: no unpublished

1976* IIA 6.4 Determination of crop residues in grass. BAY M-650616-01-2 uJäuねp2: p龿゜ädゕ゜, USA Study no.: REPORT A11 Reference no. RIP95-01213 Date: 1976-10-15 GLP: no unpublished 1977* IIA 6.4 Determination of crop residues in grass. BAY M-650797-01-2 Je3j2み5h く9hB぀z0, USA Study no.: REPORT A12 Reference no. RIP95-01214 Date: 1977-02-15 GLP: no unpublished

1994* IIA 6.4 Determination of residues of glyphosate in CHE grass (grass and hay) - treatment with CHE 3607 - UK, season 1992. )くG9(tJa?? Tlu., UK Study plan AS/1911/CN Cheminova report no. IF-93/04572-01 Reference no. RIP95-01308. Date: 1994-03-31 GLP: yes unpublished

1994* IIA 6.4 Determination of residues of glyphosate in grass CHE (grass and silage) - treatment with CHE 3607 - UK, season 1992. H!tJ?c!züx jE3., UK Study plan AS/1912/CN Cheminova report no. IF-93/13842-01 Reference no. RIP95-01312. Date: 1994-07-18 GLP: yes unpublished

Page 93 of 192

- 94 - Glyphosate –List of tests and studies Residue data Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report number No. Date GLP status, published or not

2010 IIA 14 GTF Nature of [ C]glyphosate residues in 6.5.1/01 processed commodities – High temperature hydrolysis, FLCT J.Wcj `äö., USA Report No.: PTRL 1925W-001 (study) MSL0023072 (sponsor) Date: 2010-10-07 GLP: yes unpublished

1990* IIA 6.6.2 Confined rotational crops study of Glyphosate BAY M-649963-01-2 - Part I: In-field portion. F77ftjIc`Nzö:2c/ yfjJEe7ciく-c, Inc. Study No.: MSL 9810. Report No.: RIP95-01201\ Date: 1990-01-30 GLP: yes unpublished

1990* IIA. 6.6.2 Confined rotational crops study of glyphosate BAY M-650179-01-2 - Part II: Quantitation, characterisation and identification of Glyphosate and its metabolites in rotational crops. れ_く4゜Jäj ゕ龼zkxyb, USA Study No.: MSL 9811 Report No.: RIP95-01202 Date: 1990-06-22 GLP: yes unpublished

1998 IIA LX1146-02 (Glyphosate technical) confined CHE 6.6.2/01 rotational crop study on lettuce, radish, and wheat in California eI龼ääFく1 EゕF -ä0ej:j*lf1hä -xä,. USA Study No.: 1651-91-146-01-09B- 17 Report No.: 459 GLY Date: 1998-04-20 GLP: yes unpublished

Page 94 of 192

- 95 - Glyphosate –List of tests and studies Residue data

2.2 List of all Other/Special Studies in Section IIA 6.10

A list of all Other/Special Studies in Section IIA 6.10 is presented in the tables in the following pages:

• Table 1 lists all the relevant peer-reviewed publications from the literature that were selected for inclusion in the submission. For each publication it is noted whether or not a Klimisch rating (Klimisch, 1997) is included in the review. • Table 2 lists the publications and other documents that are cited within the discussion of the literature. These include documents such as government or company reports; publications that are included in the literature review under another section of the dossier; and publications that are outside the scope of the literature review.

Table 1. Relevant glyphosate literature Annex Author(s) Year Title

point/ Citation n o reference number Category Evaluation Translati

IIA 6.10 Ando C, Segawa R, Gana 2003 Dissipation and offsite movement of forestry 1 C, Li L, Walters J, Sava herbicides in plants of importance to native R, Barry T, Goh KS, Lee Americans in California National Forests. Bulletin P, Tran D, White J, Hsu J of Environmental Contamination and Toxicology 71 (2):354-361. DOI 10.1007/s00128-003-0171-5.

IIA 6.10 Arregui MC, Lenardon A, 2004 Monitoring glyphosate residues in transgenic 1 Sanchez D, Maitre MI, glyphosate-resistant soybean. Pest Manage- ment Scotta R, Enrique Science 60 (2):163-166. Doi S 10.1002/Ps.775.

IIA 6.10 Bohm GMB, Genove- se 2008 Residues of glyphosate and 1 MI, Pigosso G, Trichez aminomethylphosphonic acid and levels of D, Rombaldi CV isoflavones in BRS 244 RR and BRS 154 soybean. Ciência e Tecnologia de Alimentos 28:192-197

IIA 6.10 Bresnahan GA, Manthey 2003 Glyphosate applied preharvest induces shikimic acid 1 FA, Howatt KA, accumulation in hard red spring wheat (Triticum Chakraborty M aestivum). Journal of Agricul- tural and Food Chemistry 51 (14):4004-4007. Doi 10.1021/Jf0301753.

IIA 6.10 Caierao E, Acosta 2007 Industrial suitability for malting of grains from 1 ADS desiccated pre-harvest barley. Pesquisa Agro- pecuaria Brasileira 42 (9):1277-1282 IIA 6.10 Cataneo AC, Déstro 2003 Glutathione S-transferase activity on the 1 GFG, Ferreira LC, degradation of the herbicide glyphosate in maize Chamma KL, Sousa (Zea mays) plants. Planta Daninha 21 (2):307- DCF 312. DOI: 10.1590/S0100- 83582003000200017.

IIA 6.10 Cessna AJ, Darwent AL, 2002 Residues of glyphosate and its metabolite AMPA 1 Townley-Smith L, Harker in field pea, barley and flax seed following KN, Kirkland KJ preharvest applications. Canadian Journal of Plant Science 82 (2):485-489

Page 95 of 192

- 96 - Glyphosate –List of tests and studies Residue data Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 6.10 Duke SO 2011 Glyphosate Degradation in Glyphosate- Resistant and 1 -Susceptible Crops and Weeds. J Agric Food Chem 59 (11):5835-5841. DOI: 10.1021/jf102704x.

IIA 6.10 Duke SO, Rimando 2003 Isoflavone, glyphosate, and 1 AM, Pace PF, Reddy aminomethylphosphonic acid levels in seeds of KN, Smeda RJ glyphosate-treated, glyphosate-resistant soybean. Journal of Agricultural and Food Chemistry 51 (1):340-344. Doi 10.1021/Jf025908i.

IIA 6.10 Gimou MM, Charrondiere 2008 Dietary exposure to pesticide residues in 1 UR, Leblanc JC, Pouillot Yaounde: the Cameroonian total diet study. Food R Addit Contam Part A Chem Anal Control Expo Risk Assess 25 (4):458-71. DOI: 10.1080/02652030701567475.

IIA 6.10 Granby K, Vahl M 2001 Investigation of the herbicide glyphosate and the 1 plant growth regulators chlormequat and mepiquat in cereals produced in Denmark. Food Additives and Contaminants 18 (10):898-905

IIA 6.10 Harris CA, Gaston CP 2004 Effects of refining predicted chronic dietary intakes 1 of pesticide residues: a case study using glyphosate. Food Additives and Conta- minants 21 (9):857-864. Doi 10.1080/02652030412331282385.

IIA 6.10 Huther L, Drebes S, 2005 Effect of glyphosate contaminated feed on rumen 1 Lebzien P fermentation parameters and in sacco degradation of grass hay and corn grain. Ar- chives of Animal Nutrition 59 (1):73-79. Doi 10.1080/17450390512331342403.

IIA 6.10 Lorenzatti E, Maitre MI, 2004 Pesticide residues in immature soybeans of 1 Argelia L, Lajma- novich Argentina croplands. Fresenius Environmental R, Peltzer P, Anglada M Bulletin 13 (7):675-678

IIA 6.10 Low FL, Shaw IC, 2005 The effect of Saccharomyces cerevisiae on the 1 Gerrard JA stability of the herbicide glyphosate during bread leavening. Letters in Applied Microbio- logy 40 (2):133-137

IIA 6.10 Nougadère A, Reninger J- 2011 Chronic dietary risk characterization for pesticide 1 Also C, Volatier J-L, Leblanc residues: A ranking and scoring method integrating listed J-C agricultural uses and food contamination data. Food under IIA and Chemical Toxi- cology 49 (7):1484-1510. DOI: 5.10 10.1016/j.fct.2011.03.024.

IIA 6.10 Reddy KN, Rimando AM, 2008 Aminomethylphosphonic acid accumulation in plant 1 Duke SO, Nandu- la VK species treated with glyphosate. J Agric Food Chem 56 (6):2125-30. DOI: 10.1021/jf072954f.

IIA 6.10 Rojano-Delgado AM, 2012 Limited uptake, translocation and enhanced 2 K Cruz-Hipolito H, De metabolic degradation contribute to glyphosate Prado R, Luque de tolerance in Mucuna pruriens var. utilis plants. Castro MD, Franco AR Phytochemistry 73 (0):34-41. DOI: 10.1016/j.phytochem.2011.09.007.

Page 96 of 192

- 97 - Glyphosate –List of tests and studies Residue data Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 6.10 Simonsen L, 2008 Fate and availability of glyphosate and AMPA in 1 Also Fomsgaard IS, agricultural soil. Journal of Environmental Science listed Svensmark B, Spliid and Health, Part B: Pesticides, Food Contaminants, under IIA NH and Agricultural Wastes 43 (5):365 - 375. DOI: 7.13 10.1080/03601230802062000.

IIA 6.10 Wagner R, Kogan M, 2003 Phytotoxic activity of root absorbed glyphosate in 1 Also Parada AM corn seedlings (Zea mays L.). Weed Biology and listed Management 3:228-232 under IIA 8.16

Table 2. Supporting publications and documents Annex point/ Author(s) Year Title reference Citation number

IIA 6.10 Carr, K.H. and Bleeke, M.S. 2012 Process Description for Identification, Review, and Also listed Categorization of Scientific Literature Concerning under Glyphosate and AMPA Side-Effects on Health, the IIA 5.10, IIA Environment, and Non-Target Species 7.13, IIA 8.16

IIA 6.10 Klimisch HJ, Andreae 1997 A systematic approach for evaluating the quality of Also listed M, Tillmann U experimental toxicological and ecotoxicological data. under Regulatory Toxicology and Pharmacology 25 (1):1-5 IIA 5.10, IIA 7.13, IIA 8.16

Page 97 of 192

- 98 - Glyphosate –List of tests and studies Environmental fate and behaviour

3. Environmental fate and behaviour

3.1 Environmental fate and behavior – Active Substance

Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report number No. Date GLP status, published or not

2012 IIA 7.12/06 Analysis of groundwater contamination with GTF glyphosate/AMPA PRL ゗zeä龿akYb0j ä/ 8t-_龿apZn0véj. z5zGlJ, France Report No.: - Date: February 2012 GLP: no (literature study: does not contain laboratory work) Not published 2011 IIA 7.12/02 Investigation of the potential glyphosate GTF groundwater contamination in Lombardia region (North Italy) Öät!d-je !P/. P゜öläcä, Italy Report No.: - Date: 20 October 2011 GLP: no (literature study: does not contain laboratory work) Published

2005 IIA 7.12/05 An investigation of reported borehole BAY M-651309-01-2 contamination in the Vemmenhög Catchment, Sweden PDダH ロし Eョ.i Dll/$§龾ul?くveJ`, England Report No.: - Date: December 2005 GLP: no (literature study: does not contain laboratory work) Not published 1997* IIA 7.4.9 Determination of the rate of volatilization of AGC glyphosate from soil and plant surface (french beans) ÄHEKH ,.ゕヌ, rJ`wfn?ö4J??iuhョ. The Netherlands Report No.: 191071 Date: 1997 GLP: yes Not published 1996a IIA 7.1.1/04 14 SYN [P-Methylene- C]glyphosate acid: aerobic soil metabolism SEBE Jj.Wä f,.kz ä!-Bjlkbjä, USA Report No.: PTRL548W-1 (study) RR 96-027B (sponsor) Date: July 11, 1996 GLP: yes Not published

Page 98 of 192

- 99 - Glyphosate –List of tests and studies Environmental fate and behaviour Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report number No. Date GLP status, published or not

2009* IIA 7.7 Ready biodegradability of glyphosate in a NUF manometric respirometry test xJj:_!/: -(_ ゕü0tJä5:8iz 0$Vcii:9 $ョ7 dIR゛ J41:j/4 Üし-RRV ゗3ロダ. ゕ1)JJ7x`, Germany Report No.: 53981163 Date: December 10, 2009 GLP: yes Not published 2002 IIA 7.8.3/01 Aminomethylphosphonic acid: fate and FSG behaviour in water-sediment A&ね z6゜T( r-く D3e//*j* 9・ü pjjfね ziz1J ゘y--J゛゛ョJqa5 Fcäz`ot ゗.Üöじ Rzpz龿`くj, Germany Report No.: A &M 01-106 (study) Date: November 12, 2002 GLP: yes Not published 2010 IIA 7.12/04 Evaluatie van metingen van glyfosaat en GTF AMPA in grondwater in Nederland (Evaluation of glyphosate and AMPA measurements in groundwater in The Netherlands) 7F:el ゕJ?cäz(ö `kfe:/゜:a・nzj. ä*lョWz*くa8 Vゕ. The Netherlands Report No.: 354 Date: October 2010 GLP: no (literature study: does not contain laboratory work) Not published

1996 IIA 7.1.1/03 NUF (14C)-Glyphosate: aerobic soil metabolism ゕöh!lh§ ?/xKäälh Z3q-ka. d/A)$ K2)jz§J・I, England Report No.: 1413/1-1015 (study) Date: July 11, 1996 GLP: yes Not published 2000* IIA 7.10 Glyphosate acid - Calculation of the half life SYN by reaction with atmospheric hydroxyl radicals 6くäく.P3/? aäiJsi1l //jヌ, UK Report No.: 46852/01 Date: February 15, 2000 GLP: no (not applicable) Not published Also filed under IIA 2.10/02

2012 IIA 7.12/07 Survey of glyphosate and AMPA in GTF groundwaters and surface waters in Europe N8ヌÖ, UK Report No.: - GLP: no (desk study: does not contain laboratory work) Not published

Page 99 of 192

- 100 - Glyphosate –List of tests and studies Environmental fate and behaviour Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report number No. Date GLP status, published or not

2008 IIA 7.12/01 Review of glyphosate and AMPA in BAY M-651160-01-2 drinking water in selected European countries Wゕa PQyölgq. :fW/jJ4/z, UK Report No.: UC7729.04 Date: September 2008 GLP: no (literature review: does not contain laboratory work) Published

2003a IIA 7.1.2 Route and rate of anaerobic soil degradation of ALS * glyphosate according to SETAC, Part 1, 1.2 (March 1995) rqJ:/j:3 aJä3JP-7l ゕ・ä龾pc:Jä 1nd jゕvj゛ *:! J?2a e1)c::8Z゛d(ä $X.A゘ )/Kaau. Germany Report No.: IF-02/00005224 Date: February 7, 2003 GLP: yes Not published

2003b IIA 7.4.2/01 Aminomethylphosphonic acid: adsorption- ALS desorption ゕTZULw-F ,FPQ, u)J゜6Jョ!) Report No.: IF-02/00005220 (study) Date: February 07, 2003 GLP: yes Not published 2003c IIA 7.8.3/02 Aerobic aquatic degradation of ALS aminomethylphosphonic acid according to SETAC, part 1.8.2 (March 1995) ETUTRQ(F PÄ,F,, J1ョJ!!`g5 rJ/jョjvi !zJ7JPätn :JRkc぀ana b・9 ゕ :n/4h:( e?Jx Zä(:tä゜vh?$f QÖ . V?-:cb, Germany Report No.: IF-02/00005222 (study) Date: February 07, 2003 GLP: yes 1996 IIA 7.4.1/02 Glyphosate: deter mination of adsorption and SIN desorption properties based on the OECD method 106 -dk(・F3:$・ Eü-zl・tJ?8`c. 8ヌy-, Switzerland Report No.: 95-111-1020 (study) Date: April 26, 1996 GLP: yes Not published 14 2003 IIA 7.1.2/01 The degradation of [ C]-glyphosate in soil BAY M-644181-01-2 under anaerobic conditions k?!Jx!o? ゕJzcIe.a2 c*hZ)c/, Scotland Report No.: 22581 (study); MSL-18018 (sponsor) Date: July 08, 2003 GLP: yes Not published

Page 100 of 192

- 101 - Glyphosate –List of tests and studies Environmental fate and behaviour Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report number No. Date GLP status, published or not

2004a IIA 7.1.2 [14C]-Glyphosate: Anaerobic soil SIN * IIA 7.2.4 metabolism (rate and route of degradation in a sandy loam soil) ゕtb゗JdXy?je JzxBäzcf Z龾q/tl?. B_yd._Jc しf龾öJlI_j4?・/く゜c, UK Report No.: SNN/05 Date: July 19, 2004 GLP: yes Not published 2004b IIA 7.8.3/03 14 SIN [ C]-AMPA: Degradation and fate in water/sediment systems C:O8vzä0぀tJ C?-äoJcc E/゗x.jjc öä&gJcダ_!/niy8$tf, UK Report No.: SNN/03 (study) Date: June 7, 2004 GLP: yes Not published 1996 IIA 7.4.5/01 14 SIN Determination of the mobility of aged [ C]- glyphosate residues in one soil P/§`h゜)66u E?§0ä:.-d)taJ $`.ヌq Switzerland Report No.: 96-121-1020 (study) Date: June 14, 1996 GLP: yes Not published 1996 IIA 7.1.1/05 14 SIN [ C]-Glyphosate: determination of soil degradation, bio-transformation and metabolism under aerobic conditions !tpp2Fnhö! Z?゛・:ja-eョ`J. Aü3), Switzerland Report No.: 96-120-1020 (study) Date: June 14, 1996 GLP: yes Not published 1996 IIA 7.4.2/03 Glyphosate acid: adsorption and desorption SYN properties of the major metabolite, AMPA, in soil TゕイTOT e3゗lU6)7äez:J. äzjsiくj-J ロ:jt ゕJeI?cäp ä4く.Pi:j ゕ!??j/z゜g C?)81Jl-c, UK Report No: RJ2129B Date: August 27, 1996 GLP: yes Not published

1995 IIA 7.1.1/02 HR-001: Aerobic soil metabolism and route of ALS degradation ゜゜üロ_6ltü§ trZz F9aa:ze Ti,.n X_`0I ョ, England Report. No.: SNY 333/951445 (study) Date: December 1, 1995 GLP: yes Not published 2010a IIA 7.1.1/01 Rate and route of degradation of GTF 14 [ C]glyphosate in one soil incubated under aerobic conditions LSゕE WcJi. )qä,. ?itqfy/zゕ-. USA Report No.: PTRL1923W-1 (study) MSL0023070 (sponsor) Date: October 6, 2010 GLP: yes Not published

Page 101 of 192

- 102 - Glyphosate –List of tests and studies Environmental fate and behaviour Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report number No. Date GLP status, published or not

14 2010b IIA 7.2.1/01 Rate of degradation of [ C]glyphosate in GTF three soils incubated under aerobic conditions SZCE JWäl. e.!4, lI4?ゕcj!1l, USA Report No.: PTRL1946W-1 (study); MSL0023071 (sponsor) Date: October 6, 2010 GLP: yes Not published

2006 IIA 7.12/03 Clarification of well-related findings of GTF glyphosate and AMPA in groundwater FUP !ü::qJ/i PfcpJa_jJ pKÄ龼. pJä5E?8kJjj, Germany Report No.: IF-06/00603024 (study) Date: 14 December 2006 GLP: no (literature study: does not contain laboratory work) Not published 1996* IIA 7.4.9 Glyphosate: Determination of volatilisation - FSG Field study H`, ?2JY) t/1ロ8?gt N぀2.w §*Uj, Germany Report No.: PR94/032 (study); Date: 1996 GLP: yes Not published 1996 IIA 7.4.1/03 Glyphosate acid: adsorption and desorption SYN properties in 5 soils ZTRQEH N’c゗iJ.*d?7:äe ?/qi(scjJ Ntjt CzäzJ`z4 Pzi:6l2. Rzöj)agz/ a-J:ゕ9・)?, UK Report No: RJ2152B Date: September 12, 1996 GLP: yes Not published 2001 IIA 7.4.1/01 Adsorption/desorption of glyphosate on soil AGC EAロDし ,,.ゕA )zicqgJIイ)1ö11Je, The Netherlands Report No.: 320164 (study) Date: December 10, 2001 GLP: yes Not published

2002 IIA 7.4.2/02 Adsorption/desorption behaviour of AMPA FSG on soil according OECD 106 (adopted January 2000) ÖRZ V゘じ.h 4§ゕjn_z, Germany Report No.: PR02/007 (study) Date: June 24, 2002 GLP: yes Not published

Page 102 of 192

- 103 - Glyphosate –List of tests and studies Environmental fate and behaviour

3.2 Environmental fate and behaviour – Representative formulation

Year Annex point/ Title Owner Bayer Document reference Source -Company name Number number Report No. Date GLP status, published or not

2012a IIIA 9.4/01 Predicted environmental concentrations of GTF IIIA 9.5 glyphosate and its metabolite AMPA in soil (PECs) following application to various crops in the EU Yゕ, HVTZÜT BAATLPヌ OnN.゘ e3qgä:龿.れ Germany Report No.: 303605-1 Date: April 25, 2012 GLP: no (modelling study: does not contain laboratory work) Not published 2012 IIIA 9.6/01 Predicted environmental concentrations of GTF b glyphosate and its metabolite AMPA in groundwater (PECgw) using FOCUS PEARL 4.4.4 and FOCUS PELMO 4.4.3 following application to various crops in the EU ロ,ゕロNZTDL AZBAPVE 龿oダ.H ヸc2?jxb龽, Germany Report No.: 303605-2 Date: April 25, 2012 GLP: no (modelling study: does not contain laboratory work) Not published 2012c IIIA 9.7.1/01 Predicted environmental concentrations of GTF IIIA 9.8 glyphosate and its metabolites AMPA and HMPA in surface water (PECsw) and sediment (PECsed) following application to various crops in the EU Vゕ, UVLDZT イZBDPXE .K龽6 じ z9cj.みöv゗ Germany Report No.: 303605-3 Date: April 27, 2012 GLP: no (modelling study: does not contain laboratory work) Not published

2012 IIIA 9.1.1/01 Kinetic modelling analysis of the degradation GTF behaviour of glyphosate and its metabolite AMPA from aerobic laboratory soil degradation studies YC, VÖLETÄ YQFTゕダE 龿VV く. qみe5ョal぀, Germany Report No.: 303604-1 Date: May 3, 2012 GLP: no (kinetic evaluation: does not contain laboratory work) Not published 2012 IIIA 9.6.4/01 Review of sustainable water treatment BAY M-651305-01-2 Wゕe 0öFKtv・. :lJt?W:g`, England Report No.: UC8408v2 Date: March 2012 GLP: no (literature review: does not contain laboratory work) Not published

Page 103 of 192

- 104 - Glyphosate –List of tests and studies Environmental fate and behaviour Year Annex point/ Title Owner Bayer Document Number reference Source -Company name number Report No. Date GLP status, published or not 2010 IIIA 9.6.4/02 Removal of glyphosate and AMPA by water BAY M-651307-01-2 treatment BW? Ph3ダtü$. liiJ?Wョ/(, England Report No.: UC8164v2 Date: October 2010 GLP: no (literature study: does not contain laboratory work) Not published 2012 IIIA 9.2.1/01 Kinetic modelling analysis of the degradation GTF behaviour of glyphosate and its metabolite AMPA in field soil dissipation studies C,Ä HTダイTT BUGLDFT N&uロ. れä.3゜5zt龿 Germany Report No.: 303604-2 Date: April 27, 2012 GLP: no (kinetic evaluation: does not contain laboratory work) Not published 2012 IIIA 9.7/01 Kinetic modelling analysis of the GTF disappearance behaviour of glyphosate and its metabolite AMPA in water-sediment studies Äゕ, しTTÄロE ゕwZYPイZ ゘.Y ゛V pcれcd3t龽, Germany Report No.: 303604-3 Date: April 30, 2012 GLP: no (kinetic evaluation: does not contain laboratory work) Not published

Page 104 of 192

- 105 - Glyphosate –List of tests and studies Environmental fate and behaviour 3.3 List of all Other/Special Studies in Section IIA 7.13

A list of all Other/Special Studies in Section IIA 7.13 is presented in three tables in the following pages:

Table 1. Relevant glyphosate literature Annex Author(s) Year Title

point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Accinelli C, Koskinen 2006 Influence of Cry1Ac toxin on mineralization and 1 WC, Sadowsky MJ bioavailability of glyphosate in soil. J Agric Food Chem 54 (1):164-9. DOI: 10.1021/jf052252v. IIA 7.13 Accinelli C, Koskinen 2005 Effects of incorporated corn residues on glyphosate 1 WC, Seebinger JD, mineralization and sorption in soil. Journal of Vicari A, Sadowsky MJ Agricultural and Food Chemistry 53 (10):4110- 4117. Doi 10.1021/Jf050168r.

IIA 7.13 Accinelli C, Screpanti 2004 Influence of insecticidal toxins from Bacillus 1 C, Vicari A, Catizone P thuringiensis subsp kurstaki on the degradation of glyphosate and glufosinate-ammonium in soil samples. Agriculture Ecosystems & Envi- ronment 103 (3):497-507. DOI 10.1016/j.agee.2003.11.002.

IIA 7.13 Adams GW, Smith T, 2007 The absence of glyphosate residues in wet soil and 1 Miller JD the adjacent watercourse after a forestry application in new Brunswick. Northern Jour- nal of Applied Forestry 24 (3):230-232

IIA 7.13 Albers CN, Banta GT, 2009 The influence of organic matter on sorption and 1 Hansen PE, Jacobsen OS fate of glyphosate in soil – Comparing different soils and humic substances. Environ- mental Pollution 157 (10):2865-2870. DOI: 10.1016/j.envpol.2009.04.004.

IIA 7.13 Alexa E, Bragea M, 2009 Dynamic of glyphosate mineralization in 1 Sumalan R, Lazureanu different soil types. Romanian Agricultural A, Negrea M, Iancu S Research 26:57-60 IIA 7.13 Alexa E, Lazureanu A, 2008 Researches regarding extractable glyphosate 1 Alda S, Negrea M, residues from different soils. Commun Agric Iordanescu O Appl Biol Sci 73 (4):861-9 IIA 7.13 Alexa E, Micu R, Negrea 2010 Research on the weed control degree and glyphosate 1 M, Sumalan R, soil biodegradation in apple plantations (Pioneer Iordanescu O variety). Analele Universi- tatii din Oradea, Fascicula Biologie 17 (1):5-8

Page 105 of 192

- 106 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Alexa E, Sumalan R, 2008 Researches regarding the microorganisms 1 Negrea M influence on glyphosate biodegradation. Jour- nal of Agroalimentary Processes and Techno- logies 14 (2):498-502

IIA 7.13 Alletto L, Coquet Y, 2010 Tillage management effects on pesticide fate in 1 Benoit P, Heddadj D, soils. A review. Agron. Sustain. Dev. 30:367- Barriuso E 400. DOI: 10.1051/agro/2009018. IIA 7.13 Al-Rajab AJ, Amellal 2008 Sorption and leaching of C-14-glyphosate in 1 S, Schiavon M agricultural soils. Agronomy for Sustainable Development 28 (3):419-428. Doi 10.1051/Agro:2008014.

IIA 7.13 Al-Rajab AJ, Schiavon 2010 Degradation of 14C-glyphosate and 1 M aminomethylphosphonic acid (AMPA) in three agricultural soils. J Environ Sci (China) 22 (9):1374-80. DOI: 10.1016/S1001- 0742(09)60264-3.

IIA 7.13 Al-Salamah IS 2004 Simulating the fate and transport of pesticide in 1 unsaturated soil: a case study with glyphosate- isopropylammonium. In Geo- Environment: Monitoring, Simulation & Remediation of the Geological Environment. , edited by J. F. Martin- Deque, Brebbia, C. A., Godfrey, A. E., Diaz de Teran, J. R. Southapmpton, UK. WIT Press. pp 275-290.

IIA 7.13 Andrade GJMd, Roso- 2011 Uptake of Manganese in RR Soybean under 1 lem CA Glifosate Application. Revista Brasileira de Ciência do Solo 35 (3):961-968. doi: 10.1590/S0100-06832011000300030.

IIA 7.13 Andréa MM, Papini S, 2004 Glyphosate: influence on the soil bioactivity and 1 Also listed Peres TB, Bazarin S, action of earthworms on its soil dissipation. . under Savoy VLT, Matallo MB Planta Daninha 22:95-100. DOI: IIA 8.16 10.1590/S0100-83582004000100012.

IIA 7.13 Andréa MMd, Peres 2003 Influence of repeated applications of glyphosate 1 TB, Luchini LC, on its persistence and soil bioactivity. Pesquisa Bazarin S, Papini S, Agropecuaria Brasileira Matallo MB, Savoy 38:1329-1335. DOI: 10.1590/S0100- VLT 204X2003001100012.

IIA 7.13 Arantes SAdCM, 2011 Effect of liming on the mineralization of (14)C- 1 Lavorenti A, Tornisielo glyphosate in soils. Ciencia e Agrotec- nologia 35 VL (2):234-241 IIA 7.13 Aronsson H, Stenberg 2011 Leaching of N, P and glyphosate from two soils 2 M, Ulén B after herbicide treatment and incorporation of a ryegrass catch crop. Soil Use and Management 27 (1):54-68. doi: 10.1111/j.1475-2743.2010.00311.x.

IIA 7.13 Assalin MR, De 2010 Studies on degradation of glyphosate by several 1 Moraes SG, Queiroz oxidative chemical processes: ozonation, photolysis SC, Ferracini VL, and heterogeneous photocatalysis. J Environ Sci Duran N Health B 45 (1):89-94. DOI: 10.1080/03601230903404598.

Page 106 of 192

- 107 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Augustin B 2003 Urban areas - source of pesticide- contamination 1 of surface water? Paper read at Second International Symposium on plant health in urban horticulture, 27-29 August, 2003, at Berlin, Germany. 166-169.

IIA 7.13 Augustin B, Seibel H 2002 Herbicide treatment of urban areas - a possible 2 source of surface water contamination. Gesun- de Pflanzen 54 (7):235-240 IIA 7.13 Autio S, Siimes K, 2004 Adsorption of sugar beet herbicides to Finnish 1 Laitinen P, Ramo S, soils. Chemosphere 55 (2):215-226. DOI Oinonen S, Eronen L 10.1016/j.chemosphere.2003.10.015. IIA 7.13 Bailey WA, Poston DH, 2002 Glyphosate interactions with manganese. Weed 1 Wilson HP, Hines TE Technology 16 (4):792-799

IIA 7.13 Balci B, Oturan MA, 2009 Decontamination of Aqueous Glyphosate, 1 Oturan N, Sirés I (Aminomethyl)phosphonic Acid, and Glufosinate Solutions by Electro-Fenton-like Process with Mn2+ as the Catalyst. Journal of Agricultural and Food Chemistry 57 (11):4888-4894. DOI: 10.1021/jf900876x.

IIA 7.13 Barja BC, dos Santos 2005 Aminomethylphosphonic Acid and Glyphosate 1 Afonso M Adsorption onto Goethite: A Comparative Study. Environmental Science & Technology 39 (2):585-592. DOI: 10.1021/es035055q.

IIA 7.13 Barrett KA, McBride 2005 Oxidative degradation of glyphosate and 1 MB aminomethylphosphonate by manganese oxide. Environmental Science & Technology 39 (23):9223-9228. Doi 10.1021/Es051342d.

IIA 7.13 Barrett KA, McBride 2007 Phosphate and glyphosate mobility in soil columns 1 MB amended with roundup. Soil Science 172 (1):17-26. DOI 10.1097/01.ss.0000240549.44551.3d.

IIA 7.13 Barrett KA, McBride 2006 Trace element mobilization in soils by 2 MB glyphosate. Soil Science Society of America Journal 70 (6):1882-1888. DOI 10.2136/sssaj2005.0415.

IIA 7.13 Basso CJ, Santi AL, 2011 Foliar application of manganese in transgenic 1 Lamego FP, Girotto E soybean tolerant to glyphosate. Ciencia Rural 41 (10):1726-1731. doi: 10.1590/S0103- 84782011001000008.

IIA 7.13 Battaglin W, Rice K, 2009 The occurrence of glyphosate, atrazine, and other 2 Focazio M, Salmons S, pesticides in vernal pools and adjacent streams in Barry R Washington, DC, Maryland, Iowa, and Wyoming, 2005–2006. Environmental Monitoring and Assessment 155 (1):281-307

IIA 7.13 Battaglin WA, Kolpin 2005 Glyphosate, other herbicides, and transformation 1 DW, Scribner EA, products in Midwestern streams, 2002. Journal of Kuivila KM, Sand- the American Water Resources Association 41 strom MW (2):323-332

IIA 7.13 Baun A, Ledin A, 2004 Xenobiotic organic compounds in leachates from 1 Reitzel LA, Bjerg PL, ten Danish MSW landfills - chemical analysis and Christensen TH toxicity tests. Water Research 38 (18):3845-3858. DOI 10.1016/j.watres.2004.07.006.

Page 107 of 192

- 108 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Bazot S, Lebeau T 2008 Simultaneous mineralization of glyphosate and 1 diuron by a consortium of three bacteria as free- and/or immobilized-cells formulations. Appl Microbiol Biotechnol 77 (6):1351-8. DOI: 10.1007/s00253-007-1259-3.

IIA 7.13 Bellaloui N, Abbas HK, 2009 Effect of glyphosate-boron application on seed 2 K Gillen AM, Abel CA composition and nitrogen metabolism in glyphosate-resistant soybean. J Agric Food Chem 57 (19):9050-6. DOI: 10.1021/jf901801z.

IIA 7.13 Bellaloui N, Reddy KN, 2009 Effects of Glyphosate Application on Seed Iron and 2 K Zablotowicz RM, Abbas Root Ferric (III) Reductase in Soybean Cultivars. HK, Abel CA Journal of Agricultural and Food Chemistry 57 (20):9569-9574. Doi 10.1021/Jf902175y.

IIA 7.13 Bellaloui N, Reddy KN, 2006 Simulated glyphosate drift influences nitrate 2 K Zablotowicz RM, assimilation and nitrogen fixation in non- Mengistu A glyphosate-resistant soybean. J Agric Food Chem 54 (9):3357-64. DOI: 10.1021/jf053198l.

IIA 7.13 Bellaloui N, Zabloto- 2008 Nitrogen metabolism and seed composition as 2 K wicz RM, Reddy KN, influenced by glyphosate application in Abel CA glyphosate-resistant soybean. J Agric Food Chem 56 (8):2765-72. DOI: 10.1021/jf703615m.

IIA 7.13 Benetoli LOB, de 2010 Adsorption of glyphosate in a forest soil: a study 1 Santana H, Carneiro using Mössbauer and FT-IR spectroscopy. CEA, Zaia DAM, Química Nova 33 (4):855-859. doi: Ferreira AS, Paesano 10.1590/S0100-40422010000400017. Jr. A, Zaia CTBV

IIA 7.13 Bergström L, Börjesson 2011 Laboratory and Lysimeter Studies of Glyphosate 2 K E, Stenström J and Aminomethylphosphonic Acid in a Sand and a Clay Soil. J. Environ. Qual. 40 (1):98-108. doi: 10.2134/jeq2010.0179.

IIA 7.13 Bernards ML, Thelen 2005 Glyphosate interaction with manganese in tank 2 K KD, Penner D, mixtures and its effect on glyphosate Muthukumaran RB, absorption and translocation. Weed Science 53 McCracken JL (6):787-794

IIA 7.13 Birch H, Mikkelsen PS, 2011 Micropollutants in stormwater runoff and combined 2 Jensen JK, Lutzhoft HCH sewer overflow in the Copenhagen area, Denmark. Water Science and Technology 64 (2):485-493. DOI: 10.2166/wst.2011.687.

IIA 7.13 Bonfleur EJ, Lavorenti 2011 Mineralization and degradation of glyphosate and 1 A, Tornisielo VL atrazine applied in combination in a Brazilian Oxisol. Journal of Environmental Science and Health Part B-Pesticides Food Contaminants and Agricultural Wastes 46 (1):69-75. doi: 10.1080/03601234.2011.534384.

IIA 7.13 Borggaard OK 2011 Does Phosphate Affect Soil Sorption and 1 Degradation of Glyphosate? – A Review. Trends in Soil & Plant Sciences Journal 2 (1):16-27

Page 108 of 192

- 109 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Borggaard OK, Gim- 2008 Fate of glyphosate in soil and the possibility of 1 sing AL leaching to ground and surface waters: a review. Pest Manag Sci 64 (4):441-56. DOI: 10.1002/ps.1512.

IIA 7.13 Bott S, Lebender U, Yoon 2009 Evidence for glyphosate damage of winter wheat 3 K DJ, Tesfamariam T, depending on waiting-times after pre- crop Romheld V, Neu- mann G glyphosate application and density of desiccated weed plants under field and experimental conditions. Paper read at The Proceedings of the International Plant Nutrition Colloquium XVI., at UC Davis.

IIA 7.13 Bott S, Tesfamariam T, 2008 Glyphosate-induced impairment of plant growth 3 K Candan H, Cakmak I, and micronutrient status in glyphosate- resistant Roemheld V, Neumann G soybean (Glycine max L.). Plant and Soil 312 (1- 2):185-194. DOI 10.1007/s11104- 008-9760-8.

IIA 7.13 Bott S, Tesfamariam T, 2011 Phytotoxicity of glyphosate soil residues re- 3 K Kania A, Eman B, Aslan mobilised by phosphate fertilisation. Plant and Soil N, Roemheld V, 342 (1-2):249-263. doi: 10.1007/s11104- Neumann G 010-0689-3.

IIA 7.13 Botta F, Lavison G, 2009 Transfer of glyphosate and its degradate AMPA to 1 Couturier G, Alliot F, surface waters through urban sewerage systems. Moreau-Guigon E, Chemosphere 77 (1):133-9. DOI: Fauchon N, Guery B, 10.1016/j.chemosphere.2009.05.008. Chevreuil M, Blanchoud H

IIA 7.13 Boucherie C, Lecarpen- 2010 Ozone and "GAC filtration" synergy for removal of 1 tier C, Fauchon N, Djafer emerging micropollutants in a drinking water M, Heim V treatment plant? Water Science and Technology: Water Supply 10 (5):860- 868. doi: 10.2166/ws.2010.837.

IIA 7.13 Bozkaya B, Daines C, 2009 Treatment of nanofiltration membrane 1 Brunel A, Schrotter JC, concentrates: Organic micropollutant and nom Breant P removal. Desalination and Water Treatment 9:36-42

IIA 7.13 Bressy A, Gromaire MC, 2012 Towards the determination of an optimal scale for 1 Lorgeoux C, Saad M, stormwater quality management: Micropollutants Leroy F, Chebbo G in a small residential catchment. Water Research. doi: 10.1016/j.watres.2011.12.017.

IIA 7.13 Brosillon S, Wolbert D, 2006 Chlorination kinetics of glyphosate and its by- 1 Lemasle M, Roche P, products: modeling approach. Water Res 40 Mehrsheikh A (11):2113-24. DOI: 10.1016/j.watres.2006.03.028.

IIA 7.13 Brown CD, van Bei- 2009 Pesticide transport via sub-surface drains in 1 num W Europe. Environmental Pollution 157 (12):3314-3324. DOI 10.1016/j.envpol.2009.06.029.

IIA 7.13 Byer JD, Struger J, 2008 Low cost monitoring of glyphosate in surface waters 1 Klawunn P, Todd A, using the ELISA method: an evaluation. Environ Sci Sverko E Technol 42 (16):6052-7 IIA 7.13 Caceres-Jensen L, Gan J, 2009 Adsorption of glyphosate on variable-charge, 1 Baez M, Fuentes R, volcanic ash-derived soils. J Environ Qual 38 Escudey M (4):1449-57. DOI: 10.2134/jeq2008.0146.

Page 109 of 192

- 110 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Cakmak I, Yazici A, 2009 Glyphosate reduced seed and leaf concentrations 3 K Tutus Y, Ozturk L of calcium, manganese, magnesium, and iron in non-glyphosate resistant soybean. European Journal of Agro- nomy 31 (3):114-119

IIA 7.13 Candela L, Alvarez- 2007 Laboratory studies on glyphosate transport in soils 1 Benedi J, de Melo of the Maresme area near Barcelona, Spain: MTC, Rao PSC Transport model parameter estimation. Geoderma 140 (1-2):8-16. DOI 10.1016/j.geoderma.2007.02.013.

IIA 7.13 Candela L, Caballero J, 2010 Glyphosate transport through weathered granite 2 Ronen D soils under irrigated and non-irrigated conditions-- Barcelona, Spain. Sci Total Envi- ron 408 (12):2509-16. DOI: 10.1016/j.scitotenv.2010.03.006.

IIA 7.13 Castro JV, Peralba 2007 Biodegradation of the herbicide glyphosate by 1 Also listed MCR, Ayub MAZ filamentous fungi in platform shaker and batch under bioreactor. Journal of Environmental Science and IIA 8.16 Health Part B-Pesticides Food Contaminants and Agricultural Wastes 42 (8):883-886. Doi 10.1080/03601230701623290.

IIA 7.13 Cerdeira AL, Duke SO 2006 The current status and environmental impacts of 1 (7.13) Also listed glyphosate-resistant crops: a review. J Envi- ron 2 (8.16) under Qual 35 (5):1633-58. DOI: IIA 8.16 10.2134/jeq2005.0378.

IIA 7.13 Cerdeira AL, Duke SO 2010 Effects of glyphosate-resistant crop cultivation on 1 soil and water quality. GM Crops 1 (1):1-9 IIA 7.13 Cerdeira AL, Gazziero 2007 Review of potential environmental impacts of 1 DLP, Duke SO, Matallo transgenic glyphosate-resistant soybean in Brazil. MB, Spadotto CA Journal of Environmental Science and Health Part B-Pesticides Food Contaminants and Agricultural Wastes 42 (5):539-549. Doi 10.1080/03601230701391542.

IIA 7.13 Chang FC, Simcik MF, 2011 Occurrence and fate of the herbicide glyphosate 2 Capel PD and its degradate aminomethylphosphonic acid in the atmosphere. Environmental Toxicology and Chemistry 30 (3):548-555. doi: 10.1002/etc.431.

IIA 7.13 Colombo SM, Masini 2011 Developing a fluorimetric sequential injection 1 JC methodology to study adsorption/desorption of glyphosate on soil and sediment samples. Mic- rochemical Journal 98 (2):260-266. doi: 10.1016/j.microc.2011.02.009.

IIA 7.13 Comoretto L, Arfib B, 2007 Pesticides in the Rhone river delta (France): Basic 1 Chiron S data for a field-based exposure assessment. Science of the Total Environment 380 (1-3):124-132. DOI 10.1016/j.scitotenv.2006.11.046.

IIA 7.13 Cornish PS, Burgin S 2005 Residual effects of glyphosate herbicide in 1 ecological restoration. Restoration Ecology 13 (4):695-702

Page 110 of 192

- 111 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Correia NM, Durigan 2009 Glyphosate and Foliar Fertilization Using 1 JC Manganese in Transgenic Soybean Crop. Plan- ta Daninha 27 (4):721-727. doi: 10.1590/S0100-83582009000400010.

IIA 7.13 Coupe RH, Kalkhoff SJ, 2012 Fate and transport of glyphosate and 1 Capel PD, Gregoire C aminomethylphosphonic acid in surface waters of agricultural basins. Pest management science 68 (1):16-30. doi: 10.1002/ps.2212.

IIA 7.13 Coutinho CFB, Mazo 2005 Metallic complexes with glyphosate: a review. 1 LH Quimica Nova 28 (6):1038-1045 IIA 7.13 Crowe AS, Leclerc N, 2011 Application of a glyphosate-based herbicide to 1 Struger J, Brown S Phragmites australis: Impact on groundwater and near-shore lake water at a beach on Georgian Bay. Journal of Great Lakes Re- search 37 (4):616-624. DOI: 10.1016/j.jglr.2011.08.001.

IIA 7.13 da Cruz LH, de Santa- na 2007 Adsorption of glyphosate on clays and soils from 1 H, Zaia CTBV, Zaia Parana state: Effect of pH and phosphate DAM competitive adsorption of phosphate. Brazilian Archives of Biology and Technology 50 (3):385- 394

IIA 7.13 da Silva MD, Peralba 2003 Determination of glyphosate and 2 MdCR, Mattos ML aminomethylphosphonic acid in supervficial waters of Arroioi Passo do Pilao. Pesticidas: R. Ecotoxicol e Meio Ambiente, Curitiba 13:19- 28

IIA 7.13 Damonte M, Torres 2007 Some aspects of the glyphosate adsorption on 1 Sánchez RM, dos San- montmorillonite and its calcined form. Applied Clay tos Afonso M Science 36 (1–3):86-94. doi: 10.1016/j.clay.2006.04.015.

IIA 7.13 Davis AM, Thorburn 2012 Environmental impacts of irrigated sugarcane 1 PJ, Lewis SE, Bain- production: Herbicide run-off dynamics from bridge ZT, Attard SJ, farms and associated drainage systems. Agri- Milla R, Brodie JE culture, Ecosystems & Environment. doi: 10.1016/j.agee.2011.06.019.

IIA 7.13 De Araujo ASF, Mon- 2003 Biodegradation of glyphosate in two Brazilian 1 teiro RTR, Abakerli RB, soils. Pesticidas: R. Ecotoxicol. E. Meio Ambiente De Souza LS 13:157-164 IIA 7.13 de Armas ED, Monteiro 2007 Spatial-temporal diagnostic of herbicide occurrence 1 RTR, Antunes PM, dos in surface waters and sediments of Corumbatai Santos MAPF, de River and main affluents. Quimica Nova 30 Camargo PB, Abakerli (5):1119-1127 RB

IIA 7.13 de Jonge H, de Jonge LW, 2001 Glyphosate sorption in soils of different pH and 2 K Jacobsen OH, Yamaguchi phosphorus content. Soil Science 166 (4):230- T, Moldrup P 238

IIA 7.13 de Paz JM, Rubio JL 2006 Application of a GIS-AF/RF model to assess the 1 risk of herbicide leaching in a citrus- growing area of the Valencia Community, Spain. Sci Total Environ 371 (1-3):44-54. DOI: 10.1016/j.scitotenv.2006.07.018.

Page 111 of 192

- 112 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 de Roffignac L, Cattan P, 2008 Efficiency of a bagasse substrate in a biological 1 Mailloux J, Herzog D, Le bed system for the degradation of glyphosate, Bellec F malathion and lambda-cyhalothrin under tropical climate conditions. Pest Mana- gement Science 64 (12):1303-1313. DOI: 10.1002/ps.1633.

IIA 7.13 de Santana H, Toni LRM, 2006 Effect in glyphosate adsorption on clays and 1 Benetoli LOdB, Zaia soils heated and characterization by FT-IR CTBV, Rosa Jr M, Zaia spectroscopy. Geoderma 136 (3-4):738-750 DAM

IIA 7.13 Dideriksen K, Stipp 2003 The adsorption of glyphosate and phosphate to 1 SLS goethite: A molecular-scale atomic force microscopy study. Geochimica Et Cosmochi- mica Acta 67 (18):3313-3327. Doi 10.1016/S0016-7037(02)01369-8.

IIA 7.13 Dion HM, Harsh JB, 2001 Competitive sorption between glyphosate and 2 K Hill HH inorganic phosphate on clay minerals and low organic matter soils. Journal of Radioanalytical and Nuclear Chemistry 249 (2):385-390

IIA 7.13 Doublet J, Mamy L, 2009 Delayed degradation in soil of foliar herbicides 2 Barriuso E glyphosate and sulcotrione previously absorbed by plants: consequences on herbicide fate and risk assessment. Chemosphere 77 (4):582-9. DOI: 10.1016/j.chemosphere.2009.06.044.

IIA 7.13 Dousset S, Chauvin C, 2004 Transfer of hexazinone and glyphosate through 1 Durlet P, Thevenot M undisturbed soil columns in soils under Christmas tree cultivation. Chemosphere 57 (4):265-272. DOI 10.1016/j.chemosphere.2004.06.007.

IIA 7.13 Dousset S, Jacobson 2007 Facilitated transport of diuron and glyphosate in 2 K AR, Dessogne JB, high copper vineyard soils. Environ Sci Technol Guichard N, Baveye 41 (23):8056-61 PC, Andreux F

IIA 7.13 Druart C, Millet M, 2011 Glyphosate and glufosinate-based herbicides: fate 1 Also listed Scheifler R, Delhomme O, in soil, transfer to, and effects on land snails. under de Vaufleury A Journal of Soils and Sediments 11 (8):1373-1384. IIA 8.16 doi: 10.1007/s11368-011- 0409-5.

IIA 7.13 Duke SO, Powles SB 2008 Glyphosate: a once-in-a-century herbicide. Pest 1 Also listed Manag Sci 64 (4):319-25. DOI: under 10.1002/ps.1518. IIA 8.16

IIA 7.13 Eberbach PL, Douglas 1983 Persistence of glyphosate in a sandy loam. Soil E K LA Biology and Biochemistry 15 (4):485-488. doi: 10.1016/0038-0717(83)90016-0. IIA 7.13 Echavia GRM, 2009 Photocatalytic degradation of organophosphate and 1 Matzusawa F, Negishi N phosphonoglycine pesticides using TiO2 immobilized on silica gel. Chemosphere 76 (5):595- 600. DOI 10.1016/j.chemosphere.2009.04.055.

Page 112 of 192

- 113 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Eker S, Ozturk L, Yazici 2006 Foliar-applied glyphosate substantially reduced 3 K A, Erenoglu B, Romheld uptake and transport of iron and manganese in V, Cakmak I sunflower (Helianthus annuus L.) plants. Jour- nal of Agricultural and Food Chemistry 54 (26):10019- 10025. Doi 10.1021/Jf0625196.

IIA 7.13 Eriksson E, Baun A, 2007 Risk assessment of xenobiotics in stormwater 2 (7.13) Also listed Mikkelsen PS, Ledin A discharged to Harrestrup angstrom, Denmark. 1 (8.16) under Desalination 215 (1-3):187-197. DOI IIA 8.16 10.1016/j.desal.2006.12.008.

IIA 7.13 Eriksson E, Baun A, 2007 Selected stormwater priority pollutants - a 1 Scholes L, Ledin A, European perspective. Science of the Total Ahlman S, Revitt M, Environment 383 (1-3):41-51. DOI Noutsopoulos C, Mik- 10.1016/j.scitotenv.2007.05.028. kelsen PS

IIA 7.13 Ermakova IT, Kiseleva 2010 Bioremediation of glyphosate-contaminated soils. 1 NI, Shushkova T, Zha- Appl Microbiol Biotechnol 88 (2):585- rikov M, Zharikov GA, 94. DOI: 10.1007/s00253-010-2775-0. Leontievsky AA

IIA 7.13 Ermakova IT, 2008 [Microbial degradation of organophosphonates by 1 Shushkova TV, soil bacteria]. Mikrobiologiia 77 (5):689-95 Leont'evskii AA IIA 7.13 Farenhorst A, Mc- 2009 Variations in soil properties and herbicide 1 Queen DAR, Saiyed I, sorption coefficients with depth in relation to Hilderbrand C, Li S, PRZM (pesticide root zone model) calculations. Lobb DA, Messing P, Geoderma 150 (3-4):267-277. DOI Schumacher TE, Pa- 10.1016/j.geoderma.2009.02.002. piernik SK, Lindstrom MJ

IIA 7.13 Farenhorst A, Papier- nik 2008 Herbicide sorption coefficients in relation to soil 1 SK, Saiyed I, Mes- sing properties and terrain attributes on a cultivated P, Stephens KD, prairie. J Environ Qual 37 (3):1201- Schumacher JA, Lobb 8. DOI: 10.2134/jeq2007.0109. DA, Li S, Lindstrom MJ, Schumacher TE

IIA 7.13 Fobbe R, Kuhlmann B, 2006 Polar Herbicides and Metabolites. In Organic 1 Nolte J, Preuß G, Skark C, Pollutants in the Water Cycle, edited by T. Zullei-Seibert N Reemtsma and M. Jekel. Weinheim. Wiley- VCH Verlag GmbH & Co. KGaA. doi: 10.1002/352760877X.ch6. pp 121-153. doi: 10.1002/352760877X.ch6.

IIA 7.13 Fomsgaard IS, Spliid 2003 Leaching of pesticides through normal-tillage and 1 K Also listed NH, Felding G low-tillage soil - A lysimeter study. II. Glyphosate. under Journal of Environmental Science and Health Part IIA 7.4.7 B-Pesticides Food Contaminants and Agricultural Wastes 38 (1):19-35. Doi 10.1081/Pfc-120016603.

IIA 7.13 Getenga ZM, Kengara 2004 Mineralization of glyphosate in compost- amended 1 FO soil under controlled conditions. Bulletin of Environmental Contamination and Toxicology 72 (2):266-275. DOI 10.1007/s00128-003-900409.

Page 113 of 192

- 114 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Ghafoor A, Jarvis NJ, 2011 Measurements and modeling of pesticide 1 Thierfelder T, Sten- persistence in soil at the catchment scale. strom J Science of The Total Environment 409 (10):1900-1908. doi: 10.1016/j.scitotenv.2011.01.049.

IIA 7.13 Ghanem A, Bados P, 2007 Concentrations and specific loads of glyphosate, 2 Estaun AR, de Alencastro diuron, atrazine, nonylphenol and metabolites LF, Taibi S, Einhorn J, thereof in French urban sewage sludge. Mougin C Chemosphere 69 (9):1368-73. DOI: 10.1016/j.chemosphere.2007.05.022.

IIA 7.13 Ghanem A, Dubroca J, 2006 Fate of herbicides and nonylphenol in soil- plant- 2 Chaplain V, Mougin C water systems amended with contaminated sewage sludge. Environmental Chemistry Letters 4 (2):63-67. DOI 10.1007/s10311-006-0034-5.

IIA 7.13 Gimsing AL, Borg- 2002 Competitive adsorption and desorption of 1 gaard OK glyphosate and phosphate on clay silicates and oxides. Clay Minerals 37 (3):509-515. Doi 10.1180/0009855023730049.

IIA 7.13 Gimsing AL, Borg- 2002 Effect of phosphate on the adsorption of glyphosate 1 gaard OK on soils, clay minerals and oxides. International Journal of Environmental Analy- tical Chemistry 82 (8-9):545-552. Doi 10.1080/0306731021000062964.

IIA 7.13 Gimsing AL, Borg- 2007 Phosphate and glyphosate adsorption by hematite 1 gaard OK and ferrihydrite and comparison with other variable-charge minerals. Clays and Clay Minerals 55 (1):108-114. DOI: 10.1346/ccmn.2007.0550109.

IIA 7.13 Gimsing AL, 2004 Influence of soil composition on adsorption of 2 K Borggaard OK, Bang M glyphosate and phosphate by contrasting Danish surface soils. European Journal of Soil Science 55 (1):183-191. DOI 10.1046/j.1365- 2389.2003.00585.x.

IIA 7.13 Gimsing AL, Borggaard 2004 Chemical and microbiological soil characteristics 1 OK, Jacobsen OS, controlling glyphosate mineralisation in Danish Aamand J, Sorensen J surface soils. Applied Soil Ecology 27 (3):233-242. DOI 10.1016/j.apsoil.2004.05.007.

IIA 7.13 Gimsing AL, Borggaard 2004 Modeling the kinetics of the competitive adsorption 1 OK, Sestoft P and desorption of glyphosate and phosphate on goethite and gibbsite and in soils. Environmental Science & Technology 38 (6):1718-1722. Doi 10.1021/Es030572u.

IIA 7.13 Gimsing AL, Szilas C, 2007 Sorption of glyphosate and phosphate by 1 Borggaard OK variable-charge tropical soils from Tanzania. Geoderma 138 (1-2):127-132. DOI 10.1016/j.geoderma.2006.11.001.

IIA 7.13 Gjettermann B, Peter- 2011 Kinetics of Glyphosate Desorption from Mobilized 2 K sen CT, Hansen S, Koch Soil Particles. Soil Science Society of America CB, Styczen M Journal 75 (2):434-443. doi: 10.2136/sssaj2010.0198.

Page 114 of 192

- 115 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Gjettermann B, Peter- 2009 Particle-facilitated Pesticide Leaching from 1 sen CT, Koch CB, Differently Structured Soil Monoliths. J. Envi- ron. Spliid NH, Grøn C, Qual. 38 (6):2382-2393. DOI: Baun DL, Styczen M 10.2134/jeq2008.0417.

IIA 7.13 Gjettermann B, Styczen 2011 Evaluation of sampling strategies for pesticides in a 1 M, Koch CB, Hansen macroporous sandy loam soil. Soil & Se- diment S, Petersen CT Contamination 20 (8):986-994 IIA 7.13 Gregoire C, 2010 Use and fate of 17 pesticides applied on a 2 Payraudeau S, vineyard catchment. International Journal of Domange N Environmental Analytical Chemistry 90 (3- 6):406-420. DOI: 10.1080/03067310903131230.

IIA 7.13 Grey TL, Vencill WK, 2009 Herbicide Dissipation from Low Density 1 Webster TM, Culpepper Polyethylene Mulch. Weed Science 57 AS (3):351-356. Doi 10.1614/Ws-08-144.1. IIA 7.13 Grundmann S, Dörfler 2008 Mineralization and Transfer Processes of 14C- 1 K Also listed U, Ruth B, Loos C, labeled Pesticides in Outdoor Lysimeters. Wa- ter, under Wagner T, Karl H, Air, & Soil Pollution: Focus 8 (2):177-185 IIA 7.4.7 Munch J, Schroll R

IIA 7.13 Grunewald K, Schmidt 2001 Behavior of glyphosate and 1 W, Unger C, aminomethylphosphonic acid (AMPA) in soils and Hanschmann G water of reservoir Radeburg II catchment (Saxony/Germany). Journal of Plant Nutrition and Soil Science-Zeitschrift Fur Pflanzener- nahrung Und Bodenkunde 164 (1):65-70

IIA 7.13 Haarstad K, Ludvigsen 2007 Ten years of pesticide monitoring in 1 GH Norwegian ground water. Ground Water Monitoring and Remediation 27 (3):75-89 IIA 7.13 Haney RL, Senseman 2002 Effect of roundup ultra on microbial activity and 1 Also listed SA, Hons FM biomass from selected soils. Journal of under Environmental Quality 31 (3):730-735 IIA 8.16

IIA 7.13 Haney RL, Senseman 2002 Soil carbon and nitrogen mineralization as 1 Also listed SA, Krutz LJ, Hons FM affected by atrazine and glyphosate. Biology and under Fertility of Soils 35 (1):35-40. DOI IIA 8.16 10.1007/s00374-001-0437-1.

IIA 7.13 Hanke I, Wittmer I, 2010 Relevance of urban glyphosate use for surface 1 Bischofberger S, water quality. Chemosphere 81 (3):422-9. DOI: Stamm C, Singer H 10.1016/j.chemosphere.2010.06.067. IIA 7.13 Henry RS, Wise KA, 2011 Glyphosate's effect upon mineral accumulation in 1 Johnson WG soybean. Crop Management (October). doi:10.1094/CM-2011-1024-01-RS. IIA 7.13 Huang XJ, Pedersen T, 2004 Herbicide runoff along highways. 1. Field 1 Fischer M, White R, observations. Environmental Science & Tech- Young TM nology 38 (12):3263-3271 IIA 7.13 Huang XJ, Pedersen T, 2004 Herbicide runoff along highways. 2. Sorption 1 Fischer M, White R, control. Environmental Science & Technology Young TM 38 (12):3272-3278

Page 115 of 192

- 116 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Jacobsen CS, van der Keur 2008 Variation of MCPA, metribuzine, 1 P, Iversen BV, Rosenberg methyltriazine-amine and glyphosate P, Barlebo HC, Torp S, degradation, sorption, mineralization and Vosgerau H, Juhler RK, leaching in different soil horizons. Environ- Ernstsen V, Rasmussen J, mental Pollution 156 (3):794-802. DOI: Brinch UC, Jacobsen OH 10.1016/j.envpol.2008.06.002.

IIA 7.13 Jia D, Zhou C, Li C 2011 Adsorption of Glyphosate on Resin Supported by 1 Hydrated Iron Oxide: Equilibrium and Kinetic Studies. Water Environment Research 83 (9):784-790. doi: 10.2175/106143011x12928814445339.

IIA 7.13 Jolley VD, Hansen NC, 2004 Nutritional and management related interactions 2 K Shiffler AK with iron-deficiency stress response mechanisms. Soil Science and Plant Nutrition 50 (7):973-981

IIA 7.13 Kah M, Brown CD 2006 Adsorption of ionisable pesticides in soils. Reviews 1 of Environmental Contamination and Toxicology 188:149-217 IIA 7.13 Kaiser K 2011 Preliminary Study of Pesticide Drift into the Maya 1 Also listed Mountain Protected Areas of Belize. Bulletin of under Environmental Contamination and Toxicology 86 IIA 8.16 (1):56-59. doi: 10.1007/s00128- 010-0167-x.

IIA 7.13 Karpouzas DG, Singh 2006 Microbial degradation of organophosphorus 2 BK xenobiotics: Metabolic pathways and molecular basis. Advances in Microbial Physi- ology, Vol 51 51:119-185. Doi 10.1016/S0065-2911(06)51003-3.

IIA 7.13 Kempenaar C, Lotz 2007 Trade off between costs and environmental 1 LAP, van der Horst effects of weed control on pavements. Crop CLM, Beltman WHJ, Protection 26 (3):430-435. DOI Leemnans KJM, 10.1016/j.cropro.2006.01.022. Bannink AD

IIA 7.13 Keshteli MR, 2011 Adsorption behavior of glyphosate in some citrus 1 Farahbakhsh M, garden soils of Iran. Electronic Journal of Savaghebi GR Environmental, Agricultural and Food Che- mistry 10 (2):1943-1951

IIA 7.13 Kilbride KM, Paveglio 2001 Long-term fate of glyphosate associated with 1 FL repeated rodeo applications to control smooth cordgrass (Spartina alterniflora) in Willapa Bay, Washington. Archives of Environmental Contamination and Toxicology 40 (2):179-183

IIA 7.13 Kim BJ, Kim Y, Kim B, 2011 Effect of soil metal contamination on glyphosate 1 Hay AG, McBride MB, mineralization: role of zinc in the mineralization Kim YS, Kim BM rates of two copper-spiked mineral soils. Environmental Toxicology and Chemistry 30 (3):596-601. DOI: 10.1002/etc.424.

IIA 7.13 Kirmser EMD, Martire 2010 Degradation of the Herbicides Clomazone, 1 DO, Gonzalez MC, Paraquat, and Glyphosate by Thermally Activated Rosso JA Peroxydisulfate. Journal of Agricul- tural and Food Chemistry 58 (24):12858- 12862. Doi 10.1021/Jf103054h.

Page 116 of 192

- 117 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Kjaer J, Ernsten V, 2011 Transport modes and pathways of the strongly 2 K Jacobsen OH, Hansen N, sorbing pesticides glyphosate and pendimethalin de Jonge LW, Olsen P through structured drained soils. Chemosphere 84 (4):471-479. doi: 10.1016/j.chemosphere.2011.03.029.

IIA 7.13 Kjaer J, Ernstsen V, de 2011 Reply to Comments on "Transport modes and 2 K Jonge LW, Olsen P pathways of the strongly sorbing pesticides glyphosate and pendimethalin through structured drained soils" by Petersen, C.T. and Hansen, S. Chemosphere 84 (4) (2011) 471- 479. Chemosphere 85 (9):1539-1541. doi: 10.1016/j.chemosphere.2011.07.003.

IIA 7.13 Kjaer J, Olsen P, Ullum 2005 Leaching of glyphosate and amino- 2 K M, Grant R methylphosphonic acid from Danish agricultural field sites. Journal of Environmen- tal Quality 34 (2):608-620

IIA 7.13 Kleter GA, Harris C, 2008 Comparison of herbicide regimes and the 1 Also listed Stephenson G, Uns- associated potential environmental effects of under worth J glyphosate-resistant crops versus what they replace IIA 8.16 in Europe. Pest Manag Sci 64 (4):479- 88. DOI: 10.1002/ps.1513.

IIA 7.13 Klier C, Grundmann S, 2008 Modelling the Environmental Fate of the Herbicide 1 Gayler S, Priesack E Glyphosate in Soil Lysimeters. Wa- ter, Air, & Soil Pollution: Focus 8 (2):187-207 IIA 7.13 Klimek M, Lejczak B, 2001 Metabolism of the phosphonate herbicide 1 Kafarski P, Forlani G glyphosate by a non-nitrate-utilizing strain of Penicillium chrysogenum. Pest Management Science 57 (9):815-821

IIA 7.13 Kogan M, Metz A, 2003 Adsorption of glyphosate in Chilean soils and its 1 Ortega R relationship with unoccupied phosphate binding sites. Pesquisa Agropecuaria Brasileira 38 (4):513-519

IIA 7.13 Kolpin D, Battaglin W, 2009 Occurrence of Transformation Products in the 1 Conn K, Furlong E, Environment. In Transformation Products of Glassmeyer S, Kalk- hoff Synthetic Chemicals in the Environment. pp S, Meyer M, Schnoebelen 83-100. DOI: 10.1007/698_2_011. D

IIA 7.13 Kolpin DK, Schnoebe- 2004 Degradates provide insight to spatial and temporal 1 len DJ, Thurman EM trends of herbicides in ground water. Ground Water 42 (4):601-608 IIA 7.13 Kolpin DW, Thurman 2006 Urban contributions of glyphosate and its 2 EM, Lee EA, Meyer degradate AMPA to streams in the United MT, Furlong ET, States. Sci Total Environ 354 (2-3):191-7. Glassmeyer ST DOI: 10.1016/j.scitotenv.2005.01.028.

IIA 7.13 Krause B, Weigert A, 2009 Organic Trace Substances Relevant for Drinking 1 Heise S, Litz N Water – Assessing their Elimination through Bank Filtration. Prepared by UBA for Berlin Centre of Competence for Water (Kompetenzzentrum Wasser Berlin gGmbH), Berlin, Germany. Available at: http://www.kompetenz- wasser.de/fileadmin/user_upload/pdf/forschun g/TRACE_final_report_09092009.pdf

Page 117 of 192

- 118 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Kremer RJ, Means NE, 2005 Glyphosate affects soybean root exudation and 3 K Kim S rhizosphere micro-organisms. International Journal of Environmental Analytical Chemistry 85 (15):1165-1174. Doi 10.1080/03067310500273146.

IIA 7.13 Laitinen P, Rämö S, 2009 Glyphosate and phosphorus leaching and 2 K Nikunen U, Jauhiainen L, residues in boreal sandy soil. Plant and Soil Siimes K, Turtola E 323 (1):267-283 IIA 7.13 Laitinen P, Ramo S, 2007 Glyphosate translocation from plants to soil - does 2 Siimes K this constitute a significant proportion of residues in soil? Plant and Soil 300 (1-2):51- 60. DOI 10.1007/s11104-007-9387-1.

IIA 7.13 Laitinen P, Siimes K, 2006 Fate of the herbicides glyphosate, glufosinate- 1 Eronen L, Ramo S, ammonium, phenmedipham, ethofumesate and Welling L, Oinonen S, metamitron in two Finnish arable soils. Pest Manag Mattsoff L, Ruohonen- Sci 62 (6):473-91. DOI: Lehto M 10.1002/ps.1186.

IIA 7.13 Laitinen P, Siimes K, 2008 Effects of soil phosphorus status on environmental 2 K Ramo S, Jauhiainen L, risk assessment of glyphosate and glufosinate- Eronen L, Oinonen S, ammonium. J Environ Qual 37 (3):830-8. DOI: Hartikainen H 10.2134/jeq2007.0256.

IIA 7.13 Lamprea K, Ruban V 2011 Characterization of atmospheric deposition and 2 runoff water in a small suburban catchment. Environmental Technology 32 (10):1141-1149. DOI: 10.1080/09593330.2010.528045.

IIA 7.13 Lamprea K, Ruban V 2011 Pollutant concentrations and fluxes in both 1 stormwater and wastewater at the outlet of two urban watersheds in Nantes (France). Urban Water Journal 8 (4):219-231. doi: 10.1080/1573062x.2011.596211.

IIA 7.13 Lancaster SH, Hollister 2010 Effects of repeated glyphosate applications on soil 2 Also listed EB, Senseman SA, Gentry microbial community composition and the under TJ mineralization of glyphosate. Pest Manag Sci IIA 8.16 66 (1):59-64. DOI: 10.1002/ps.1831.

IIA 7.13 Landry D, Dousset S, 2005 Leaching of glyphosate and AMPA under two soil 2 K Fournier JC, Andreux F management practices in Burgundy vineyards (Vosne-Romane'e, 21-France). Envi- ronmental Pollution 138 (2):191-200. DOI 10.1016/j.envpol.2005.04.007.

IIA 7.13 Lane M, Lorenz N, 2012 Microbial activity, community structure and 1 Also listed Saxena J, Ramsier C, potassium dynamics in rhizosphere soil of soybean under Dick RP plants treated with glyphosate. Pedo- biologia 55 IIA 8.16 (3):153-159. doi: 10.1016/j.pedobi.2011.12.005.

IIA 7.13 Lashermes G, Barriuso 2012 Dissipation pathways of organic pollutants during 1 E, Houot S the composting of organic wastes. Che- mosphere. doi: 10.1016/j.chemosphere.2011.12.004.

IIA 7.13 Lashermes G, Houot S, 2010 Sorption and mineralization of organic 1 Barriuso E pollutants during different stages of composting. Chemosphere 79 (4):455-462. DOI: 10.1016/j.chemosphere.2010.01.041.

Page 118 of 192

- 119 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Lexow C, Morell I, 2005 Glyphosate mobility in piedmont soils of the 1 Bonorino AG Australes range in the south of Buenos Aires Province. Edited by E. H. M. A. U. E. Bocanegra. ed. vols. Vol. 6, Groundwater and Human Development. 'Original edition',

IIA 7.13 Lin CH, Lerch RN, Goyne 2011 Reducing Herbicides and Veterinary Antibiotics 1 KW, Garrett HE Losses from Agroecosystems Using Vegetative Buffers. Journal of Environ- mental Quality 40 (3):791-799. doi: 10.2134/jeq2010.0141.

IIA 7.13 Litz NT, Weigert A, 2011 Comparative studies on the retardation and 1 Krause B, Heise S, reduction of glyphosate during subsurface Gruetzmacher G passage. Water Research 45 (10):3047-3054. DOI: 10.1016/j.watres.2011.02.015.

IIA 7.13 Ludvigsen GH, Lode O 2001 Results from "JOVA" - The agricultural and 1 environmental monitoring program of pesticides in Norway 1995-1999. Fresenius Environmental Bulletin 10 (5):470-474

IIA 7.13 Ludvigsen GH, Lode O 2002 Trends of Pesticides in Norwegian Streams and 1 Rivers (1996-2000). International Journal of Environmental Analytical Chemistry 82 (8- 9):631-643. DOI: 10.1080/0306731021000062982.

IIA 7.13 Machado AFL, Ferreira 2009 Absorption, translocation and radicular glyphosate 1 LR, Tuffi Santos LD, exudation in Eucalyptus sp. clones. Planta Daninha Santos JB, Ferreira FA, 27 (3):549-554. doi: Viana RG 10.1590/s0100-83582009000300016.

IIA 7.13 Magga Z, Tzovolou DN, 2008 Soil column experiments used as a means to 1 Theodoropoulou MA, assess transport, sorption, and biodegradation of Dalkarani T, Piki- os K, pesticides in groundwater. J Environ Sci Health B Tsakiroglou CD 43 (8):732-41. DOI: 10.1080/03601230802388868.

IIA 7.13 Magga Z, Tzovolou 2012 Combining experimental techniques with non- 1 DN, Theodoropoulou linear numerical models to assess the sorption of MA, Tsakiroglou CD pesticides on soils. Journal of Contaminant Hydrology 129/130:62-69. doi: 10.1016/j.jconhyd.2011.09.010.

IIA 7.13 Maillard E, Payraudeau 2011 Removal of pesticide mixtures in a stormwater 1 S, Faivre E, Gregoire C, wetland collecting runoff from a vineyard Gangloff S, Imfeld G catchment. Science of The Total Environment 409 (11):2317-2324. doi: 10.1016/j.scitotenv.2011.01.057.

IIA 7.13 Maillard E, Payraudeau 2012 Removal of dissolved pesticide mixtures by a 1 S, Ortiz F, Imfeld G stormwater wetland receiving runoff from a vineyard catchment: an inter-annual comparison. International Journal of Environ- mental Analytical Chemistry:1-16. doi: 10.1080/03067319.2011.609935.

Page 119 of 192

- 120 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Major WW, Grue CE, 2003 Concentrations of glyphosate and AMPA in 1 Also listed Gardner SC, Grassley sediment following operational applications of under JM Rodeo (R) to control smooth cordgrass in Willapa IIA 8.16 Bay, Washington, USA. Bulletin of Environmental Contamination and Toxicology 71 (5):912-918. DOI 10.1007/s00128-003- 8905-y.

IIA 7.13 Malaguerra F, Al- 2010 Contamination of drinking water supply wells by 1 brechtsen HJ, Binning pesticides from surface water resources. In PJ Proceedings of the XVIII International Conference on Water Resources, edited by J. Carrera. CIMNE, Barcelona. CMWR. pp 746- 756.

IIA 7.13 Malaguerra F, Al- 2012 Pesticides in water supply wells in Zealand, 1 brechtsen HJ, Thorling L, Denmark: A statistical analysis. Science of The Binning PJ Total Environment 414:433-444. doi: 10.1016/j.scitotenv.2011.09.071.

IIA 7.13 Malone RW, Shipitalo 2004 Residual and contact herbicide transport through 1 MJ, Wauchope RD, field lysimeters via preferential flow. Journal of Sumner H Environmental Quality 33 (6):2141- 2148

IIA 7.13 Mamy L, Barriuso E 2007 Desorption and time-dependent sorption of 1 herbicides in soils. European Journal of Soil Science 58 (1):174-187 IIA 7.13 Mamy L, Barriuso E 2005 Glyphosate adsorption in soils compared to 1 herbicides replaced with the introduction of glyphosate resistant crops. Chemosphere 61 (6):844-855. DOI 10.1016/j.chemosphere.2005.04.051.

IIA 7.13 Mamy L, Barriuso E, 2005 Environmental fate of herbicides trifluralin, 1 Gabrielle B metazachlor, metamitron and sulcotrione compared with that of glyphosate, a substitute broad spectrum herbicide for different glyphosate-resistant crops. Pest Management Science 61 (9):905-916. Doi 10.1002/Ps.1108.

IIA 7.13 Mamy L, Gabrielle B, 2010 Comparative environmental impacts of glyphosate 2 Barriuso E and conventional herbicides when used with glyphosate-tolerant and non-tolerant crops. Environ Pollut 158 (10):3172-8. DOI: 10.1016/j.envpol.2010.06.036.

IIA 7.13 Mamy L, Gabrielle B, 2008 Measurement and modelling of glyphosate fate 2 Barriuso E compared with that of herbicides replaced as a result of the introduction of glyphosate- resistant oilseed rape. Pest Manag Sci 64 (3):262-75. DOI: 10.1002/ps.1519.

IIA 7.13 Manassero A, Passalia C, 2010 Glyphosate degradation in water employing the 1 Negro AC, Cassano AE, H2O2/UVC process. Water Research 44 (13):3875- Zalazar CS 82. DOI: 10.1016/j.watres.2010.05.004.

IIA 7.13 Mattos MLT, Peralba 2002 Environmental Monitoring Of Glyphosate and Its 1 MDCR, Dias SLP, Metabolite (aminomethylphosphonic acid) In Prata F, Camargo L Tillage Water Of Irrigated Rice. Pesticidas: R.Ecotoxicol. e Meio Ambiente, Curitiba 12:145-154

Page 120 of 192

- 121 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Mehrsheikh A, Bleeke 2006 Investigation of the mechanism of chlorination of 1 M, Brosillon S, glyphosate and glycine in water. Water Research 40 Laplanche A, Roche P (16):3003-3014. DOI 10.1016/j.watres.2006.06.027.

IIA 7.13 Messing PG, Farenhorst 2011 Predicting wetland contamination from 2 A, Waite DT, McQueen atmospheric deposition measurements of DAR, Sproull JF, pesticides in the Canadian Prairie Pothole Humphries DA, region. Atmospheric Environment 45 Thompson LL (39):7227-7234

IIA 7.13 Moneke AN, Okpala 2010 Biodegradation of glyphosate herbicide in vitro 1 GN, Anyanwu CU using bacterial isolates from four rice fields. African Journal of Biotechnology 9 (26):4067- 4074

IIA 7.13 Morillo E, Undabeytia T, 2002 The effect of dissolved glyphosate upon the 2 Maqueda C, Ramos A sorption of copper by three selected soils. Chemosphere 47 (7):747-752 IIA 7.13 Motavalli PP, Kremer 2004 Impact of genetically modified crops and their 1 Also listed RJ, Fang M, Means NE management on soil microbially mediated plant under nutrient transformations. Journal of Environ- mental IIA 8.16 Quality 33 (3):816-824

IIA 7.13 Neumann G, Kohls S, 2006 Relevance of glyphosate transfer to non-target 3 K Landsberg E, Stock- plants via the rhizosphere. Journal of Plant Oliveira Souza K, Ya- Diseases and Protection (Special Issue mada T, Romheld V 20):963-969

IIA 7.13 Newton M, Cole EC, 2008 Dissipation of four forest-use herbicides at high 1 Tinsley IJ latitudes. Environ Sci Pollut Res Int 15 (7):573-83. DOI: 10.1007/s11356-008-0039-7. IIA 7.13 Nourouzi MM, Chuah 2010 Adsorption of glyphosate onto activated carbon 1 TG, Choong TSY derived from waste newspaper. Desali- nation and Water Treatment 24 (1-3):321-326. doi: 10.5004/dwt.2010.1461.

IIA 7.13 Nourouzi MM, Chuah 2011 Glyphosate utilization as the source of carbon: 1 TG, Choong TSY, Lim isolation and identification of new bacteria. E- CJ Journal of Chemistry 8 (4):1582-1587 IIA 7.13 Nowack B 2002 Aminopolyphosphonate removal during 1 wastewater treatment. Water Research 36:4636-4642 IIA 7.13 Olesen CF, Cedergreen 2010 Glyphosate uncouples gas exchange and 1 N chlorophyll fluorescence. Pest Manag Sci 66 (5):536-42. DOI: 10.1002/ps.1904. IIA 7.13 Orcaray L, Zulet A, 2012 Impairment of carbon metabolism induced by the 1 Zabalza A, Royuela M herbicide glyphosate. Journal of plant physiology 169 (1):27-33. doi:10.1016/j.jplph.2011.08.009.

IIA 7.13 Ozturk L, Yazici A, Eker 2008 Glyphosate inhibition of ferric reductase activity in 3 K S, Gokmen O, Rolmheld iron deficient sunflower roots. New Phytologist V, Cakmak I 177 (4):899-906. DOI 10.1111/j.1469-8137.2007.02340.x.

IIA 7.13 Pappas EA, Smith DR 2007 Effects of dredging an agricultural drainage ditch on 1 water column herbicide concentration, as predicted by fluvarium techniques. Journal of Soil and Water Conservation 62 (4):262-268

Page 121 of 192

- 122 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Peruzzo PJ, Porta AA, 2008 Levels of glyphosate in surface waters, sediments 1 Ronco AE and soils associated with direct sowing soybean cultivation in north pampasic region of Argentina. Environ Pollut 156 (1):61-6. DOI: 10.1016/j.envpol.2008.01.015.

IIA 7.13 Pesce S, Fajon C, Bardot 2008 Longitudinal changes in microbial planktonic 2 Also listed C, Bonnemoy F, Portelli communities of a French river in relation to under C, Bohatier J pesticide and nutrient inputs. Aquat Toxicol 86 IIA 8.16 (3):352-60. DOI: 10.1016/j.aquatox.2007.11.016.

IIA 7.13 Peschka M, Müller J, 2006 Trends in Pesticide Transport into the River 2 Knepper T, Seel P Rhine. In The Rhine. pp 155-175. IIA 7.13 Pessagno RC, dos 2005 N-(Phosphonomethyl) Glycine Interactions 1 Santos Afonso M, With Soils. J. Argent. Chem. Soc. 93 (4-6):97- Torres Sanchez RM 108 IIA 7.13 Pessagno RC, Sanchez 2008 Glyphosate behavior at soil and mineral-water 1 RAT, Afonso MD interfaces. Environmental Pollution 153 (1):53- 59. DOI 10.1016/j.envpol.2007.12.025. IIA 7.13 Petersen CT, Hansen S 2011 Comments on ‘‘Transport modes and pathways of 2 K the strongly sorbing pesticides glyphosate and pendimethalin through structured drained soils” by J. Kjær, V. Ernsten, O.H. Jacobsen, N. Hansen, L.W. de Jonge, P. Olsen [Chemosphere 84(4) (2011) 471–479]. Che- mosphere 85 (9):1538. doi: 10.1016/j.chemosphere.2011.06.111.

IIA 7.13 Pizzul L, Castillo MD, 2009 Degradation of glyphosate and other pesticides by 1 Stenstrom J ligninolytic enzymes. Biodegradation 20 (6):751- 759. DOI 10.1007/s10532-009-9263- 1.

IIA 7.13 Prata F, Cardinali 2003 Glyphosate Sorption And Desorption In Soils 1 VCdB, Lavorenti A, With Distinct Phosphorus Levels. Scientia Tornisielo VL, Agricola 60 (1):175-180 Regitano JB

IIA 7.13 Prata F, Lavorenti A, 2005 Glyphosate behavior in a rhodic oxisol under no- 1 Regitano JB, till and conventional agricultural systems. Revista Vereecken H, Brasileira De Ciencia Do Solo 29 (1):61-69 Tornisielo VL, Pelissari A

IIA 7.13 Puertolas L, Damasio J, 2010 Evaluation of side-effects of glyphosate mediated 2 Also listed Barata C, Soares AM, Prat control of giant reed (Arundo donax) on the under N structure and function of a nearby Mediterranean IIA 8.16 river ecosystem. Environ Res 110 (6):556-64. DOI: 10.1016/j.envres.2010.05.004.

IIA 7.13 Quaghebeur D, De 2004 Pesticides in rainwater in Flanders, Belgium: 2 Smet B, De Wulf E, results from the monitoring program 1997- Steurbaut W 2001. Journal of Environmental Monitoring 6 (3):182-190. Doi 10.1039/B312558k.

IIA 7.13 Queiroz GMP, da Silva 2011 Glyphosate transport in runoff and leaching 2 MR, Ferraz Bianco RJ, waters in agricultural soil. Química Nova 34 Pinheiro A, Kaufmann V (2):190-195. doi: 10.1590/s0100- 40422011000200004.

Page 122 of 192

- 123 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Rampoldi EA, Hang S, 2011 The Fate of Glyphosate in Crop Residues. Soil 1 Barriuso E Science Society of America Journal 75 (2):553-559. doi: 10.2136/sssaj2010.0105. IIA 7.13 Ramwell CT, Heather 2004 Herbicide loss following application to a railway. 1 AIJ, Shepherd AJ Pest Management Science 60 (6):556- 564. Doi 10.1002/Ps.850. IIA 7.13 Ramwell CT, Heather 2002 Herbicide loss following application to a 1 AIJ, Shepherd AJ roadside. Pest Management Science 58 (7):695-701. Doi 10.1002/Ps.506. IIA 7.13 Reddy KN, Bellaloui 2010 Glyphosate effect on shikimate, nitrate reductase 2 K Also listed N, Zablotowicz RM activity, yield, and seed composition in corn. J under Agric Food Chem 58 (6):3646-50. DOI: IIA 8.16 10.1021/jf904121y.

IIA 7.13 Reimer M, Farenhorst 2005 Effect of manure on glyphosate and trifluralin 1 A, Gaultier J mineralization in soil. Journal of Environmental Science and Health Part B- Pesticides Food Contaminants and Agricultural Wastes 40 (4):605-617. Doi 10.1081/Pfc- 200061562.

IIA 7.13 Rosolem CA, Andrade 2009 Manganese uptake and redistribution in soybeans as 1 GJM, Lisboa IP, Zoca affected by glyphosate. In The Proceedings of the SM International Plant Nutrition Colloquium XVI, Department of Plant Sciences, University of California-Davis. Retrieved from: http://escholarship.org/uc/item/3f53794z.

IIA 7.13 Rosolem CA, de An- 2010 Manganese uptake and redistribution in soybean as 1 drade GJM, Lisboa IP, affected by glyphosate. Revista Brasileira de Ciência Zoca SM do Solo 34 (6):1915-1922 IIA 7.13 Ruban V, Larrarte F, 2005 Quantitative and qualitative hydrologic balance for a 1 Berthier M, Favreau L, suburban watershed with a separate sewer system Sauvourel Y, Letellier L, (Nantes, France). Water Science and Technology 51 Mosisni ML, Raimbault (2):231-238 G

IIA 7.13 Sanchís J, Kantiani L, 2011 Determination of glyphosate in groundwater 2 Llorca M, Rubio F, samples using an ultrasensitive immunoassay and Ginebreda A, Fraile J, confirmation by on-line solid-phase extraction Garrido T, Farré M followed by liquid chromatography coupled to tandem mass spectrometry. Analyti- cal and Bioanalytical Chemistry:1-11. doi: 10.1007/s00216-011-5541-y.

IIA 7.13 Santos JB, Ferreira EA, 2007 Effects of glyphosate formulations on transgenic 1 Reis MR, Silva AA, soybean. Planta Daninha 25:165- Fialho CMT, Freita MAM 171

IIA 7.13 Sasal MC, Andriulo 2010 Glyphosate losses by drainage and runoff from 1 AE, Wilson MG, Porte- la Mollisois under no-till agriculture. Información SI tecnológica 21 (5):135-142. doi: 10.4067/S0718-07642010000500017.

IIA 7.13 Schmidt H, Boas P 2006 Accompanying experiments on weed control on 1 public footways using the roller wiper ‘Rotofix’ Nachrichtenbl. Deut. Pflanzen- schutzd. 58 (2):46-49

Page 123 of 192

- 124 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Schnurer Y, Persson P, 2006 Effects of surface sorption on microbial 2 Nilsson M, Nordgren A, degradation of glyphosate. Environ Sci Tech- nol Giesler R 40 (13):4145-50 IIA 7.13 Schonherr J, Schreiber 2004 Interactions of calcium ions with weakly acidic 1 L active ingredients slow cuticular penetration: A case study with glyphosate. Journal of Agricul- tural and Food Chemistry 52 (21):6546-6551. Doi 10.1021/Jf049500s.

IIA 7.13 Schoonenberg Kegel FS, 2010 Reverse osmosis followed by activated carbon 1 Rietman BM, Ver- liefde filtration for efficient removal of organic ARD micropollutants from river bank filtrate. Water Science and Technology 61 (10):2603-2610. doi: 10.2166/wst.2010.166.

IIA 7.13 Schroll R, Becher HH, 2006 Quantifying the effect of soil moisture on the 1 Dorfler U, Gayler S, aerobic microbial mineralization of selected Hartmann HP, Ruoss J pesticides in different soils. Environmental Science & Technology 40 (10):3305-3312. Doi 10.1021/Es052205j.

IIA 7.13 Screpanti C, Accinelli 2005 Glyphosate and glufosinate-ammonium runoff 1 C, Vicari A, Catizone P from a corn-growing area in Italy. Agronomy for Sustainable Development 25 (3):407-412. Doi 10.1051/Agro:2005031.

IIA 7.13 Selim S, Klik A, Gril- 2010 The sorption of Glyphosate and its metabolite 1 litsch B, Fürhacker M, amino-methyl-phosphonic acid (AMPA) on Mentler A biopolymer chitin. ALVA-Jahrestagung 331- 333

IIA 7.13 Serra AP, Marchetti ME, 2011 Glyphosate influence on nitrogen, manganese, iron, 2 da Silva Candido AC, copper and zinc nutritional efficiency in glyphosate Dias ACR, Christoffoleti resistant soybean. Ciencia Rural 41 (1):77-84. doi: PJ 10.1590/S0103- 84782011000100013.

IIA 7.13 Shareef KA, Hamada- 2009 Adsorption of Metalaxyl and Glyphosate on Six 1 min SI Erbilian Agricultural Soils. Asian Journal of Chemistry 21 (4):2673-2683 IIA 7.13 Sheals J, Sjoberg S, 2002 Adsorption of glyphosate on goethite: Molecular 1 Persson P characterization of surface complexes. Environmental Science & Techno- logy 36 (14):3090-3095. Doi 10.1021/Es010295w.

IIA 7.13 Shen Y, Ma J, Zhao X, 2011 Ozonation of Herbicide Glyphosate. Acta 1 Liu S, Lan H Scientiae Circumstantiae 31 (8):1647-1652. doi: 0253- 2468(2011)31:8<1647:xyyhjj>2.0.tx;2-k.

IIA 7.13 Shipitalo MJ, Malone 2008 Impact of glyphosate-tolerant soybean and 1 RW, Owens LB glufosinate-tolerant corn production on herbicide losses in surface runoff. J Environ Qual 37 (2):401-8. DOI: 10.2134/jeq2006.0540.

IIA 7.13 Shipitalo MJ, Owens 2011 Comparative Losses of Glyphosate and Selected 1 LB Residual Herbicides in Surface Runoff from Conservation-tilled Watersheds Planted with Corn or Soybean. J. Environ. Qual. 40 (4):1281- 1289. doi: 10.2134/jeq2010.0454.

Page 124 of 192

- 125 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Shushkova T, 2010 Glyphosate bioavailability in soil. 1 Ermakova I, Biodegradation 21 (3):403-10. DOI: Leontievsky A 10.1007/s10532-009-9310-y. IIA 7.13 Shushkova TV, 2009 Sorption and microbial degradation of glyphosate 1 Vasilieva GK, in soil suspensions. Applied Bio- chemistry and Ermakova IT, Microbiology 45 (6):599-603. doi: Leontievsky AA 10.1134/s0003683809060040.

IIA 7.13 Siimes K, Ramo S, 2006 Comparison of the behaviour of three herbicides in a 1 Welling L, Nikunen U, field experiment under bare soil conditions. Laitinen P Agricultural Water Management 84 (1-2):53-64. DOI 10.1016/j.agwat.2006.01.007.

IIA 7.13 Sillanpaa MET, 2011 Degradation of chelating agents in aqueous 1 Kurniawan TA, Lo W solution using advanced oxidation process (AOP). Chemosphere 83 (11):1443-1460. doi: 10.1016/j.chemosphere.2011.01.007.

IIA 7.13 Simonsen L, 2008 Fate and availability of glyphosate and AMPA in 1 Also listed Fomsgaard IS, agricultural soil. Journal of Environmental Science under Svensmark B, Spliid and Health, Part B: Pesticides, Food Contaminants, IIA 6.10 NH and Agricultural Wastes 43 (5):365 - 375. DOI: 10.1080/03601230802062000.

IIA 7.13 Skark C, Zullei-Seibert 2004 Contribution of non-agricultural pesticides to 1 N, Willme U, Gatze- pesticide load in surface water. Pest Manage- mann U, Schlett C ment Science 60 (6):525-530. Doi 10.1002/Ps.844.

IIA 7.13 Soltani N, Shropshire 2011 Short Communication: Influence of manganese on 1 C, Sikkema P efficacy of glyphosate in glyphosate- resistant soybean. Canadian Journal of Plant Science 91 (6):1061-1064. doi: 10.4141/cjps2011-035.

IIA 7.13 Sorensen SR, Schultz 2006 Sorption, desorption and mineralisation of the 1 A, Jacobsen OS, Aa- herbicides glyphosate and MCPA in samples from mand J two Danish soil and subsurface profiles. Environ Pollut 141 (1):184-94. DOI: 10.1016/j.envpol.2005.07.023.

IIA 7.13 Sorvari J, Jaakkonen S 2011 Environmental Risks Caused by Pesticides at 1 Also listed Forest Nurseries in Finland. Human and Eco- under logical Risk Assessment 17 (2):431-466. doi: IIA 8.16 10.1080/10807039.2011.552398.

IIA 7.13 Spanoghe P, Claeys J, 2005 Rainfastness and adsorption of herbicides on hard 1 Pinoy L, Steurbaut W surfaces. Pest Management Science 61 (8):793- 798. Doi 10.1002/Ps.1063. IIA 7.13 Speich P, Reulet P 2005 Evaluation Of Pesticides Transfers In Waters. 1 Case Of the Basins Slopes With Vineyards. Phytoma 582:11-14 IIA 7.13 Spliid NH, Helweg A, 2006 Leaching and degradation of 21 pesticides in a full- 1 Heinrichson K scale model biobed. Chemosphere 65 (11):2223-32. DOI: 10.1016/j.chemosphere.2006.05.049.

Page 125 of 192

- 126 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Stadlbauer H, Fank J, 2005 Lysimeteruntersuchungen zur Verlagerung von 1 K Also listed Lorbeer G Glyphosate im Lichte der Anwendung von under Pflanzenschutzmitteln zur Beseitigung von IIA 7.4.7 winterharten Grundecken. [Lysimeter investigations on the removal of glyphosate in light of the application of pesticides for the removal of winter green cover.]. Paper read at 11. Lysimetertagung, Lysimetrie im Netzwerk der Dynamik von Ökosystemen 5 und 6 April 2005, at Raumberg-Gumpenstein, Austria. 131-136.

IIA 7.13 Starrett SK, Klein J 2008 Glyphosate Runoff When Applied to Zoysiagrass 1 under Golf Course Fairway Conditions. In Fate of Nutrients and Pesticides in the Urban Environment, edited by M. T. Nett, M. J. Carroll, B. P. Horgan and A. M. Petrovic. ACS Symposium Series, Volume 997. Chapter 14. pp 237-253. doi: 10.1021/bk- 2008-0997.ch014.

IIA 7.13 Stefanello FF, 2011 Effect of glyphosate and manganese on nutrition 1 Marchetti ME, da Silva and yield of transgenic glyphosate- resistant EF, Stefanello J, Doreto soybean. Semina: Ciencias Agrarias (Londrina) RBS, Novelino JO 32 (3):1007-1014. doi: 10.5433/1679-0359.2011v32n3p1007.

IIA 7.13 Stenrod M, Charnay 2006 Spatial variability of glyphosate mineralization and 1 MP, Benoit P, Eklo soil microbial characteristics in two Norwegian OM sandy loam soils as affected by surface topographical features. Soil Biology & Biochemistry 38 (5):962-971. DOI 10.1016/j.soilbio.2005.08.014.

IIA 7.13 Stenrod M, Eklo OM, 2005 Effect of freezing and thawing on microbial activity 1 Charnay MP, Benoit P and glyphosate degradation in two Norwegian soils. Pest Management Science 61 (9):887-898. Doi 10.1002/Ps.1107.

IIA 7.13 Stone WW, Wilson JT 2006 Preferential flow estimates to an agricultural tile 1 drain with implications for glyphosate transport. J Environ Qual 35 (5):1825-35. DOI: 10.2134/jeq2006.0068.

IIA 7.13 Strange-Hansen R, Holm 2004 Sorption, mineralization and mobility of N- 1 PE, Jacobsen OS, (phosphonomethyl)glycine (glyphosate) in five Jacobsen CS different types of gravel. Pest Management Science 60 (6):570-578. Doi 10.1002/Ps.842.

IIA 7.13 Struger J, Thompson 2008 Occurrence of glyphosate in surface waters of 1 D, Staznik B, Martin P, Southern Ontario. Bull Environ Contam Toxicol McDaniel T, Marvin C 80 (4):378-84. DOI: 10.1007/s00128- 008-9373-1.

IIA 7.13 Styczen M, Petersen CT, 2011 Macroscopic Evidence of Sources of Particles for 1 Koch CB, Gjetter- mann Facilitated Transport during Intensive Rain. Vadose B Zone Journal 10 (4):1151-1161. doi: 10.2136/vzj2010.0124.

IIA 7.13 Sudol T, Krzysko- 2005 Direct indicators of determination of glyphosate 1 Pulicka T decomposition by filamentous fungi. Physicochemical Problems of Mineral Processing : . 39:257-261

Page 126 of 192

- 127 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Suhadolc M, Schroll R, 2010 Single application of sewage sludge - Impact on 1 Hagn A, Doerfler U, the quality of an alluvial agricultural soil. Schloter M, Lobnik F Chemosphere 81 (11):1536-1543. doi: 10.1016/j.chemosphere.2010.08.024.

IIA 7.13 Sumalan R, Alexa E, 2009 Researches concerning the structure and activity of 1 Megrea M, Dehelea C edaphic microflora community when glyphosate is added. Analele Universita- tii din Oradea, Fascicula Biologie 16 (2):142- 145

IIA 7.13 Sviridov A, Shushkova T, 2012 Distribution of glyphosate and methylphosphonate 1 Zelenkova N, Vinokurova catabolism systems in soil bacteria Ochrobactrum N, Morgunov I, Ermakova anthropi and Achromobacter sp. Applied I, Leontievsky A Microbiology and Biotechnology 93 (2):787-796. DOI: 10.1007/s00253-011-3485-y.

IIA 7.13 Sviridov AV, Zelenko- va 2011 New approaches to identification and activity 1 NF, Vinokurova NG, estimation of glyphosate degradation enzymes. Ermakova IT, Biochemistry-Moscow 76 (6):720-725. doi: Leontievsky AA 10.1134/s0006297911060149.

IIA 7.13 Swift KI, Bell FW 2011 What are the environmental consequences of using 1 Also listed silviculturally effective forest vegetation under management treatments? Forestry Chronicle 87 IIA 8.16 (2):201-216

IIA 7.13 Syversen N 2005 Cold-climate vegetative buffer zones as 1 pesticide-filters for surface runoff. Water Science and Technology 51 (3-4):63-71 IIA 7.13 Syversen N, Bechmann 2004 Vegetative buffer zones as pesticide filters for 1 M simulated surface runoff. Ecological Enginee- ring 22 (3):175-184. DOI 10.1016/j.ecoleng.2004.05.002.

IIA 7.13 Tesfamariam T, Bott S, 2009 Glyphosate in the rhizosphere--Role of waiting 3 K Cakmak I, Römheld V, times and different glyphosate binding forms Neumann G in soils for phytotoxicity to non-target plants. European Journal of Agronomy 31 (3):126-132

IIA 7.13 Todorovic GR 2009 Behavior of organic pollutants in the soil 1 environment. Special focus on glyphosate and AMPA. Edited by A. P. E. V. G. V. A. L. Manos Dassenakis. ed. vols. Vol., Air, water and soil quality. 'Original edition',

IIA 7.13 Todorovic GR, Mentler A, 2010 Dispersion of glyphosate in soils through erosion. 1 Rampazzo N, Blum WEH, Paper read at International Congress Eder A, Strauss of Air, water and soil pollution, at Imola, Italy. P 125-138.

IIA 7.13 Torstensson L, Borjes- 2005 Efficacy and fate of glyphosate on Swedish railway 2 K son E, Stenstrom J embankments. Pest Management Science 61 (9):881-886. Doi 10.1002/Ps.1106. IIA 7.13 Tsui MTK, Chu LM 2008 Environmental fate and non-target impact of 1 glyphosate-based herbicide (Roundup (R)) in a subtropical wetland. Chemosphere 71 (3):439- 446. DOI 10.1016/j.chemosphere.2007.10.059.

Page 127 of 192

- 128 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Tsui MTK, Wang WX, 2005 Influence of glyphosate and its formulation 1 Also listed Chu LM (Roundup (R)) on the toxicity and bioavailability of under metals to Ceriodaphnia dubia. Environmental IIA 8.16 Pollution 138 (1):59-68. DOI 10.1016/j.envpol.2005.02.018.

IIA 7.13 Tuffi Santos LD, 2005 Root Exudation of Glyphosate by Brachiaria 1 Ferreira FA, Barros decumbens and its Effects on Eucalypt Plants and NF, Siqueira CH, Microbial Soil Respiration. Planta Daninha Santos IC, Machado 23 (1):143-152 AFL

IIA 7.13 Tuffi Santos LD, 2009 Leaf anatomy and morphometry in three eucalypt 1 Sant'Anna-Santos BF, clones treated with glyphosate. Brazi- lian Journal Meira RMSA, Ferreira of Biology 69 (1):129-136 FA, Tiburcio RAS, Machado AFL

IIA 7.13 Tuffi Santos LD, San- 2008 Radicular exudation of glyphosate by Brachiaria 1 tos JB, Ferreira FA, decumbens and its effects on eucalypt plant. Planta Oliveira JA, Bentiven- Daninha 26 (2):369-374. doi: 10.1590/S0100- ha S, Machado AFL 83582008000200013.

IIA 7.13 Veiga F, Zapata JM, 2001 Dynamics of glyphosate and 1 Marcos MLF, Alvarez E aminomethylphosphonic acid in a forest soil in Galicia, north-west Spain. Science of the Total Environment 271 (1-3):135-144

IIA 7.13 Vereecken H 2005 Mobility and leaching of glyphosate: a review. Pest 2 Management Science 61 (12):1139-1151. Doi 10.1002/Ps.1122. IIA 7.13 Vinther FP, Brinch UC, 2008 Field-scale variation in microbial activity and soil 1 Elsgaard L, Fredslund L, properties in relation to mineralization and sorption Iversen BV, Torp S, of pesticides in a sandy soil. J Environ Qual 37 Jacobsen CS (5):1710-8. DOI: 10.2134/jeq2006.0201.

IIA 7.13 Vischetti C, Perucci P, 2006 Biochemical parameter changes in urban-waste 1 Casucci C, Monaci E, compost used as biofilter for pesticide Dumontet S decontamination. International Journal of Envi- ronmental Analytical Chemistry 86 (3-4):195- 205. Doi 10.1080/03067310500249849.

IIA 7.13 Vogel JR, Linard JI 2011 Agricultural herbicide transport in a first-order 2 intermittent stream, Nebraska, USA. Applied Engineering in Agriculture 27 (1):63-74 IIA 7.13 Waiman CV, Avena 2012 A simple and rapid spectrophotometric method to 1 MJ, Garrido M, quantify the herbicide glyphosate in aqueous media. Fernández Band B, Application to adsorption isotherms on soils and Zanini GP goethite. Geoderma 170:154-158. doi: 10.1016/j.geoderma.2011.11.027.

IIA 7.13 Wang MD, Cheng FX, Si 2009 The Inhibition of the Combined Pollution of 1 YB Copper and Glyphosate to the Seed Germination and Root Elongation of Wheat. Asian Journal of Ecotoxicology 4 (4):591-596

IIA 7.13 Wang N, Besser JM, 2005 Influence of sediment on the fate and toxicity of a 1 Also listed Buckler DR, Honegger polyethoxylated tallowamine surfactant system under JL, Ingersoll CG, Johnson (MON 0818) in aquatic microcosms. IIA 8.16 BT, Kurtzweil ML, Chemosphere 59 (4):545-551. DOI MacGregor J, McKee MJ 10.1016/j.chemosphere.2004.12.009.

Page 128 of 192

- 129 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Wang YH, Li X, Zhou 2010 Residue and field decline study of glyphosate- 1 XM, Bai LY, Cai HL ammonium in ramie field. Nongyaoxue Xue- bao 12 (2):201-206. doi: 10.3969/j.issn.1008- 7303.2010.02.15.

IIA 7.13 Wang Y-J, Cui Y-X, 2009 Adsorption Kinetics of Glyphosate and Copper(II) 1 Zhou D-M, Wang S-Q, Alone and Together on Two Types of Soils. Soil Xiao A-Y, Wang R-H, Sci. Soc. Am. J. 73:1995-2001. Zhang H doi:10.2136/sssaj2008.0360.

IIA 7.13 Wang YJ, Zhou DM, 2005 Effects of phosphate on the adsorption of glyphosate 2 Sun RJ on three different types of Chinese soils. Journal of Environmental Sciences-China 17 (5):711-715

IIA 7.13 Wang YJ, Zhou DM, 2006 Cosorption of zinc and glyphosate on two soils with 2 Sun RJ, Cang L, Hao different characteristics. J Hazard Mater XZ 137 (1):76-82. DOI: 10.1016/j.jhazmat.2006.02.032.

IIA 7.13 Warnemuende EA, 2007 Effects of tilling no-till soil on losses of atrazine 1 Patterson JP, Smith and glyphosate to runoff water under variable DR, Huang C-h intensity simulated rainfall. Soil and Tillage Research 95 (1-2):19-26. DOI: 10.1016/j.still.2006.09.001.

IIA 7.13 Weaver MA, Krutz LJ, 2007 Effects of glyphosate on soil microbial 1 Also listed Zablotowicz RM, Red- communities and its Mississippi soil. Pest under dy KN Management Science 63 (4):388-393. Doi IIA 8.16 10.1002/Ps.1351.

IIA 7.13 Xu D, Meyer S, 2009 Land use and riparian effects on prairie 1 Gaultier J, Farenhorst wetland sediment properties and herbicide A, Pennock D sorption coefficients. J Environ Qual 38 (4):1757-65. DOI: 10.2134/jeq2008.0357.

IIA 7.13 Xu X, Ji F, Fan Z, He L 2011 Degradation of Glyphosate in Soil Photocatalyzed 1 by Fe(3)O(4)/SiO(2)/TiO(2) under Solar Light. International Journal of Environmental Research and Public Health 8 (4):1258-1270. doi: 10.3390/ijerph8041258.

IIA 7.13 Yang YJ, Haught RC, 2009 Real-time contaminant detection and classification 1 Goodrich JA in a drinking water pipe using conventional water quality sensors: Techniques and experimental results. Journal of Environ- mental Management 90 (8):2494-2506. DOI 10.1016/j.jenvman.2009.01.021.

IIA 7.13 Yu Y, Zhang H, Zhou 2011 Using Soil Available P and Activities of Soil 1 Q Dehydrogenase and Phosphatase as Indicators for Biodegradation of Organophosphorus Pesticide Methamidophos and Glyphosate. Soil and Sediment Contamination: An International Journal 20 (6):688- 701. doi: 10.1080/15320383.2011.594110.

IIA 7.13 Yu Y, Zhou QX 2005 Adsorption characteristics of pesticides 1 methamidophos and glyphosate by two soils. Chemosphere 58 (6):811-816. DOI 10.1016/j.chemosphere.2004.08.064.

Page 129 of 192

- 130 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Yu Y, Zhou QX, He 2005 Effects of methamidophos and glyphosate on 1 ZL copper sorption-desorption behavior in soils. Science in China Series C-Life Sciences 48 (1):67-75. doi: 10.1007/bf02889803.

IIA 7.13 Zabaloy MC, Zanini 2011 Herbicides in the Soil Environment: Linkage 1 Also listed GP, Bianchinotti V, Between Bioavailability and Microbial Ecology. In under Gomez MA, Garland Herbicides, Theory and Applications, edited by S. IIA 8.16 JL Soloneski and M. L. Larramendy. Croatia. InTech. pp 161-192.

IIA 7.13 Zablotowicz RM, Ac- 2009 Soil depth and tillage effects on glyphosate 1 cinelli C, Krutz LJ, degradation. J Agric Food Chem 57 (11):4867- Reddy KN 71. DOI: 10.1021/jf900272w. IIA 7.13 Zablotowicz RM, Red- 2004 Impact of glyphosate on the Bradyrhizobium 1 dy KN japonicum symbiosis with glyphosate-resistant transgenic soybean: A minireview. Journal of Environmental Quality 33 (3):825-831

IIA 7.13 Zgheib S, Moilleron R, 2012 Priority pollutants in urban stormwater: Part 1 2 Chebbo G – Case of separate storm sewers. Water Re- search. doi: 10.1016/j.watres.2011.12.012. IIA 7.13 Zgheib S, Moilleron R, 2010 What priority pollutants occur in stormwater and 2 Chebbo G wastewater? WIT Transactions on Ecology and the Environment (Water Pollution X) 135:3-13. doi: 10.2495/WP100011.

IIA 7.13 Zhao BZ, Zhang JB, 2009 Glyphosate mobility in soils by phosphate 1 Gong JD, Zhang H, application: Laboratory column experiments. Zhang CZ Geoderma 149 (3-4):290-297. DOI 10.1016/j.geoderma.2008.12.006.

IIA 7.13 Zhao RB, Bao HY, Liu 2010 Isolation and Characterization of Penicillium 1 YX oxalicum ZHJ6 for Biodegradation of Methamidophos. Agricultural Sciences in Chi- na 9 (5):695-703. doi: 10.1016/s1671- 2927(09)60145-0.

IIA 7.13 Zhou DM, Wang YJ, 2004 Adsorption and cosorption of cadmium and 1 Cang L, Hao XZ, Luo glyphosate on two soils with different XS characteristics. Chemosphere 57 (10):1237- 1244. DOI 10.1016/j.chemosphere.2004.08.043.

IIA 7.13 Zhou Y, Wang Y, 2010 Differential Transport of Atrazine and 2 Hunkeler D, Zwahlen F, Glyphosate in Undisturbed Sandy Soil Boillat J Column. Soil and Sediment Contamination: An International Journal 19 (3):365 - 377

IIA 7.13 Zobiole LH, Kremer 2011 Glyphosate affects micro-organisms in 2 K RJ, Oliveira RS, Jr., rhizospheres of glyphosate-resistant soybeans. J Constantin J Appl Microbiol 110 (1):118-27. DOI: 10.1111/j.1365-2672.2010.04864.x.

IIA 7.13 Zobiole LH, Oliveira 2010 Glyphosate affects seed composition in 2 K RS, Visentainer JV, glyphosate-resistant soybean. J Agric Food Kremer RJ, Bellaloui Chem 58 (7):4517-22. DOI: N, Yamada T 10.1021/jf904342t.

IIA 7.13 Zobiole LHS, Bonini EA, 2010 Glyphosate affects lignin content and amino acid 2 K de Oliveira RS, Kremer production in glyphosate-resistant soybean. Acta RJ, Ferrarese O Physiologiae Plantarum 32 (5):831-837

Page 130 of 192

- 131 - Glyphosate –List of tests and studies Environmental fate and behaviour Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 7.13 Zobiole LHS, de 2010 Glyphosate reduces shoot concentrations of 3 K Oliveira RS, Huber mineral nutrients in glyphosate-resistant DM, Constantin J, de soybeans. Plant and Soil 328 (1-2):57-69 Castro C, de Oliveira FA, de Oliveira A

IIA 7.13 Zobiole LHS, de Oliveira 2010 Water use efficiency and photosynthesis of 2 K RS, Kremer RJ, glyphosate-resistant soybean as affected by Constantin J, Bonato CM, glyphosate. Pesticide Biochemistry and Phy- Muniz AS siology 97 (3):182-193

IIA 7.13 Zobiole LHS, de 2010 Nutrient Accumulation and Photosynthesis in 2 K Oliveira RS, Kremer Glyphosate-Resistant Soybeans Is Reduced under RJ, Muniz AS, de Glyphosate Use. Journal of Plant Nutri- tion 33 Oliveira A (12):1860-1873

IIA 7.13 Zobiole LHS, Kremer 2010 Glyphosate affects photosynthesis in first and 2 K RJ, de Oliveira RS, second generation of glyphosate-resistant Constantin J soybeans. Plant and Soil 336 (1-2):251-265 IIA 7.13 Zobiole LHS, Kremer 2011 Glyphosate affects chlorophyll, nodulation and 2 K RJ, Oliveira RS, nutrient accumulation of "second generation" Constantin J glyphosate-resistant soybean (Glycine max L.). Pesticide Biochemistry and Physiology 99 (1):53-60

IIA 7.13 Zobiole LHS, Oliveira 2011 Prevention of RR Soybean Injuries Caused by 2 K RS, Constantin J, Biffe Exogenous Supply of Aminoacids. Planta Daninha DF 29 (1):195-205 IIA 7.13 Zobiole LHS, Oliveira 2010 Use of Exogenous Amino Acid to Prevent 2 K RS, Constantin J, Biffe Glyphosate Injury in Glyphosate-Resistant DF, Kremer RJ Soybean. Planta Daninha 28 (3):643-653 IIA 7.13 Zobiole LHS, Oliveira 2010 Effect of glyphosate on symbiotic N(2) fixation 2 K RS, Kremer RJ, and nickel concentration in glyphosate-resistant Constantin J, Yamada T, soybeans. Applied Soil Ecology 44 (2):176-180 Castro C, Oliveira FA, Oliveira A

Table 2. Supporting publications and documents Annex point/ Author(s) Year Title reference Citation number

IIA 7.13 Carr, K.H. and Bleeke, M.S. 2012 Process Description for Identification, Review, and Also listed Categorization of Scientific Literature Concerning under Glyphosate and AMPA Side-Effects on Health, the IIA 5.10, Environment, and Non-Target Species IIA 6.10, IIA 8.16 IIA 7.13 Klimisch HJ, Andreae M, 1997 A systematic approach for evaluating the quality of Also listed Tillmann U experimental toxicological and ecotoxicological data. under Regulatory Toxicology and Pharmacology 25 (1):1-5 IIA 5.10, IIA 6.10, IIA 8.16

Page 131 of 192

- 132 - Glyphosate –List of tests and studies Ecotoxicology

4 Ecotoxicology

4.1 Ecotoxicology - Active substance

Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1978 IIA One-Generation Reproduction Study – Bobwhite BAY M-645463-01-2 * 8.1.4./03 Quail; Glyphosate Technical. 7/`äW:it fij9ä(vzlqq?/ Zjü Jü.Läj9 ?!o:2$れc, USA Report No: 139-141 Date: 1978-11-01 GLP: no Not published

1978 IIA One-Generation Reproduction Study - Mallard BAY M-646733-01-2 8.1.4./04 Duck; Glyphosate technical. tlWj:§Iz :ceht!k-0/joe /1E Zä:dJ§. e_ね`t?9o, USA Report No: 139-143 Date: 1978-09-25 GLP: no Not published

1998 IIA 96-Hour Acute Toxicity Study in Rainbow trout AGC 8.2.1/05 with (Aminomethyl)Phosphonic Acid (Static). イ ZYじO ロC,. dkくp しK J(D5a3くa'a):0xJ3, The Netherlands Report No: 232469 Date: 1998-06-29 GLP: yes Not published

1998 IIA Acute Toxicity Study in Daphnia magna with AGC 8.3.1.1./08 (Aminomethyl)Phosphonic Acid (Static). じLUNN ,イR. ・ö29 Äヌ J)c!ip$b0'A*?_Je, The Netherlands Report No: 232471 Date: 1998-06-29 GLP: yes Not published

1998 IIA 8.4/10 Fresh Water Algal Growth Inhibition Test with AGC (Aminomethyl)Phosphonic Acid ZGKOK ,O.C 49kh じw '-l2z9JIダa6ョ2Ja・, The Netherlands Report No: 232458 Date: 1998-06-30 GLP: yes Not published

1994 IIA Tier 2 Vegetative Vigor Nontarget Phytotoxicity BAY M-646735-01-2 * 8.12/02 Study Using Glyphosate Sしö!je$/ä/äh`/ö) e.T$J prz,. 0?-.ヸze B/!ytz/ry? 5゛2h$. USA Report No: MSL-13320 Date: 1994-01-14 GLP: yes Not published

Page 132 of 192

- 133 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2005 IIA Evaluation of the toxicity of Glyphosate and BAY M-645907-01-2 8.12/05 Paraquat to terrestrial non-target plants Rョ e龾qflbä jnv龾z/T$゜`5l? JJcJJ龽äG$/J. R?öョ 4龿`jä. U.K. Report No: CEA.104 Date: 2005-09-19 GLP: no Not published 2003 IIA 8.4/09 MON 78623: A 72-Hour Toxicity Test with the BAY M-648220-01-2 Freshwater Alga (Selenastrum capricornutum) Wtb:ji`? a:lpz`ö/fvä0i. Zi6,. n6§n z!u゘゘caa A- j6ä. ZäJ5・.i ?*/0ね`?・ b8゜oy, USA Report No: WL-2002-148 Date: 2003-02-11 GLP: Yes not published

2000 IIA Acute Toxicity of Glifosate Técnico Nurfarm to NUF 8.2.1/03 Zebrafish (Brachydanio rerio) R_–te`/ ??0f:pJTöhfl 6E/?. ゕ§ FnJ::e n$ó 2 BZF 71゛kf.hh38 :!c/oFeeä? ゜ FS Brasil Report No: RF-D61.47/99 Date: 2000-01-26 GLP: yes not published

2000 IIA Chronic Toxicity of Glifosate Técnico Nufarm to NUF 8.2.3/01 Zebrafish larvae (Brachydanio rerio) Cuä くfj/ Z?0?/lJ.§)u!・ Päp ?d7.Si Brasil Report No: RF-D62.16/99 Date: 2000-01-13 GLP: yes not published

2000 IIA 8.4/01 Acute toxicity of glifosate tecnico NUFARM to NUF Selenastrum capricornutum BIOAGRI E?:)3ョョ)cョjJ eEl2 Fee:?c0t-c, Brasil Report No: RF-D2.44/99 Date: 2000-01-03 GLP: yes not published

2002 IIA 8.4/07 A study on the Toxicity of Glyphosate ALS isopropylamine salt 62.5% BZL Ä?3uvj゜p:くip:5? し龼_K. S:?t.5- J9& Germany Report No: A-99-02-04 Date: 2002-11-27 GLP: yes not published

1996 IIA Glyphosate acid: A Tier 2 greenhouse Study to SYN 8.12/03 Assess the Effects on Vegetative Vigour of Terrestrial Non-Target Plants. Tpäääz f*?aJ.しく゜a龾lzj ?cjx:/s- J Ntt/ BJfz§??ä :bFl?:u. !zv9/ゕeat y§l?RzfJ), UK Report No:RJ2009B Date: 1996-09-16 GLP: yes Not published

Page 133 of 192

- 134 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1996 IIA Glyphosate acid: A Tier 2 greenhouse Study to SYN 8.12/04 Assess the Effects on Seedling Emergence of Terrestrial Non-Target Plants. vLzza? じü!&.゜e6ctz?jJ e:ljs?゜(J /jUl ゕ?Jäeä’ö :l8kFie. )a・üa/jCc Rz`gJ2j-c, UK Report No:RJ2008B Date: 1996-09-19 GLP: yes Not published 2010 IIA An extended laboratory bioassay of the effects of GTF 8.8.2.2/01 fresh residues of MON 52276 on the predatory mite, Typhlodromus pyri (Acari: Phytoseiidae) み?1!E0぀゜9 E龿/:/?n. ゜ w/゛Iz3ä 5.ゕ?u ゕj:yョ:K7f Fz?b:e? )S?*. Fn・lö゘jz288 PöA9 8G.S UK Report No: MT-2009-404 Date: 2010-04-27 GLP: yes not published

2000 IIA Acute toxicity of glifosate tecnico Nufarm to NUF 8.3.1.1/03 Daphnia magna ゕHw`!ロゕ Tv!j8yäョz!/ .E:öe (Sf?c1tä:zz, Brasil Report No: RF-D51.39/99 Date: 2000-01-17 GLP: yes not published

2000 IIA Acute toxicity of glifosato IPA tecnico Nufarm to NUF 8.3.1.1./06 Daphnia magna rイHゕ(Rじ ?ü):öuEbz‘t Elz.x r/`eätz?6äS, Brasil Report No: RF-D51.017/00 Date: 2000-07-31 GLP: yes not published

2000 IIA Acute Contact Toxicity of GLIFOSATO IPA NUF 8.7.1/06 TECHNICO NUFARM to Honey Bees (Apis mellifera L.) ロfR`ÖXゕ j8(JTc_y(ej3 T/k?,. j(aäFälc0c, Brasil Report No: RF-D4.017/00 Date: 2000-07-24 GLP: yes not published

2000 IIA Side-Effects of Glifosate Técnico Nufarm on Soil NUF 8.10.1/01 Microflora Carbon and Nitrogen Cycles 8ch:ゕl- Ecqqjo!eI:kJ E:ve. óB 3J/tS? ghd n BLS 2$34)o.vüy !äzFj?ä/ä・ 3 FS Brasil Report No: RF-D1. 113/99 Date: 2000-01-05 GLP: yes not published

1999 IIA Glyphosate Acid: A Reproduction Study with the SYN 8.1.4./01 Northern Bobwhite (Colinus virginianus) W:ij2l(? (xjc(?2?l:$8: Z/v ä58LJj. ncみz)i2_, USA Report No: 123-186 Date: 1999-05-13 GLP: yes Not published

Page 134 of 192

- 135 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1999 IIA Glyphosate Acid: A reproduction Study with the SYN 8.1.4./02 Mallard (Anas platyrhynchos) t/W/4t(? iäzo:(v`5/:゜c j゛Z TäJ.:vくみjexäfb ゜, USA Report No: 123-187 Date: 1999-01-11 GLP: yes Not published

2009 IIA MON0139 - Sublethal toxicity to the earthworm GTF 8.9.2/01 Eisenia fetida Rpゕ5c龾j ゛IeK!. Thvä` 7(( Clt:Je1äöョ§ kü_ ゕz゛z.p぀jJa w?Jz7Il?pg/, Germany Report No: 09 10 48 056 S Date: 2009-11-30 GLP: yes Not published

2010 IIA MON0139 – Effects on the reproduction of the GTF 8.9.2/06 collembolans Folsomia candida ゕ/_&・R? eq)eI. cü5!E hIf _8lä8/inJgz 9ö3 ?/?ョää_぀J ロ 0tく?//y V龽ョ.w 2zj`OnI`J? ・ä 7. 4く4q§ )nn9X?leJz/, Germany Report No: 09 10 48 057 S Date: 2010-02-02 GLP: yes 2010 IIA AM PA – Effects on the Reproduction of the GTF 8.9.2/08 collembolans Folsomia candida Cä:ョゕ゛぀ ?`ä)3. IZ?gp 9-I _J・2j゛:2:az ゜52 e/J?3ä゗?ö H?vly5j/ Ü8.龿Ü Ux?J:eョ?゜ I)f n. hßßョ6 )töJä.Näz$jp Germany Report No: 10 10 48 054 S Date: 2010-09-07 GLP: yes 2003 IIA MON b78623:li hd An Acute Oral Toxicity Study with the BAY M-646873-01-2 8.1.1./05 Northern Bobwhite i゛-äW:il f/a-・?/g?4l§:. Zn/,. 0üdg R ゛龽゘zI?? fkäAl. 0.TzJ:・み-jeüüä3 49yhu. USA Report No: WL-2002-151 Date: 2003-10-10 GLP: no Not published 2003 IIA Laboratory bioassays to determine acute oral and BAY M-644180-01-2 8.7.1/07 contact toxicity of MON 78623 to the honeybee, II A 8.7.2 Apis mellifera れ?&ygo8fE Tö./, ゕcej/ョ龾k:z :JPäc2eä Rョ$ld/jk. ゕJz/eJ: Jeä§B`c: LJ:.? ü2*Pül?龼_j$ ÖqPョ 3Sし. UK Report No: MT-2002-108 Date: 2003-04-11 GLP: yes not published

Page 135 of 192

- 136 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2010 IIA Glyphosate acid: Early life-stage toxicity test with CHE 8.2.4./01 rainbow trout (Oncorhynchus mykiss) under flow-through conditions ゗jPlu?IJ KlJtzk?l HX pn5d 3Y`p, Switzerland Report No: 1005.029.321 Date: December 23, 2010 GLP: yes not published

1994 IIA LX1146-02 (Glyphosate Technical) Tier II Non- CHE 8.12/01 Target hazard Evaluation – Terrestrial Vegetative Vigor EpktJä 6z(7z:/く9z:.(i -5?,. ロc:.ygJ:z ロX . USA Report No: 236 GLY Date: 1994-07-22 GLP: yes Not published

2000 IIA A laboratory investigation of the effects of glyphosate BAY M-644841-01-2 8.9.2/02 and its breakdown product AMPA on reproduction in the earthworm Eisenia fetida. みBT _it?Uäüjzi äf7F/?zJ E3l, Q)*/b YplJa, Great Britain Report No: CEMR-1173 Date: 2000-03-27 GLP: yes Not published

1987 IIA 8.4/05 The Toxicity of Glyphosate Technical to BAY M-644071-01-2 * Skeletonema costatum zヸä/゜t龿 S`alö:. `gz, jWdjz Fic:.1J VO ゛4u_u, USA Report No: 1092-02-1100-3 Date: 1987-04-27 GLP: no Not published

1994 IIA Acute Toxicity in Daphnia magna; Test Article: FSG 8.3.1.1./05 'Glyphosate isopropylamine salt' R(ゕ ken7öJP)Jö V぀5Ä. W?iJk`nz, Germany Report No: 83-91-0737-00-93 Date: 1994-01-28 GLP: yes not published

1997 IIA Glyphosate acid. Acute oral toxicity (LD50) to SYN 8.1.1/01 Bobwhite quail Ä_b/nョ1:9く Zträ äczFlo? ,E/ö. ョt4N_/ö1d1. ゕ?d`-?&:*_?J*/, UK Report No: ISN 400/963858 Date: 1997-02-03 GLP: yes not published

Page 136 of 192

- 137 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1995 IIA Glyphosate acid: Acute Toxicity to Bluegill SYN 8.2.1/02 Sunfish (Lepomis macrochirus) R-/xc龾u Td)§゘zy/zhl*i ic_üe/・(o.` LLQZBロ. E゛,.j Rlb1龼)c. V゛.zö8 pEロョ.ゕÖ UK Report No: BL5553/B Date: 1995-12-21 GLP: yes not published

1995 IIA GLYPHOSATE ACID: Acute Toxicity to SYN 8.2.1/01 rainbow trout (Oncorhynchus mykiss) (龽ゕjön? ::zL2n-öh龿c7j c8.E゛`?l_`く TGZGE ゕ Zt龿a/jv. RI:kz4゘ cdhじ0 ZKx 4CK. UK Report No: BL5552/B Date: 1995-12-8 GLP: yes Not published

1994 IIA AMPA: Acute toxicity to rainbow trout SYN 8.2.1/06 (Oncorhynchus mykiss) n぀RIt゜e Lhq゗i:9t-8a8z Ze9`egk`i_. ÖRLTTイ T:゛&//a. fvoCl?龾 G?3d2 LX1 N・ゕ, UK Report No: BL5070/B Date: 1994-02-10 GLP: yes Not published

1995 IIA Testing Toxicity to Honeybee - Apis mellifera L. FSG 8.7.1/01 (laboratory) according to EPPO Guideline No II A 8.7.2 170. Glyphosate (tec.) Rjy§zゕ龽 Ö゘pA `jJ74wzfä. Zz0-5 くz)J3rB7h4I. BfJbu()6yö?. Germany Report No: 95 10 48 065 Date: 1995-09-11 GLP: yes not published

2012 IIA Comparative Post-Emergence Phytotoxicity of BAY M-651389-01-2 8.16.1/01 AMPA and Glyphosate to Crop and Annual Weed Species れ61äö/4J Rv龼gz1_. F,i ・gJEl. みt$y.JJIj np3・h, USA Report No: MSL0024009 Date: 2012-04-10 GLP: no Not published

2000 IIA Glyphosate technical: Determination of toxicity to SYN 8.15/01 Pseudomonas putida )yq?Rl龽 j(_゘i?tLvく7?v exü- j_g.Eä- a?aeLö Z/::?_龼. C(t゛5龾ä. Äc1ü2, UK Report No: BL6889/B Date: 2000-06-19 GLP: yes not published

Page 137 of 192

- 138 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1999 IIA Glyphosate acid: Chronic toxicity to Daphnia SYN 8.3.2.1/01 magna tb龽ゕ!*z h/゗jZ$Iq゛ä5/ä Eeoq.゛`c:I5 Eo?ääe i$El぀la. j3.C!くz゘ ?く9イ・, UK Report No: BL6535/B Date: 1999-06-29 GLP: yes not published 2002 IIA 8.4/08 Isopropylamine Salt of Glyphosate Acid: SIN Toxicity to the Freshwater Alga Scenedesmus subspicatus RヸL Ök?///qlzz Fz-olä?J /,Zx. a!4Jzゕq/-. L4:c53§. U.K. Report No: CEMR-1874 Date: not stated GLP: yes Not published

2002 IIA Sinon Glyphosate Technical: The Acute Toxicity to SIN 8.9.1/01 the Earthworm Eisenia foetida RwTヸF. _i?Ui?1z S!§?. cSz)ö0k8 y.ゕe_ (kしbl じz.J9: C)ョ_zäJl`, UK Report No: CEMR-1875 Date: 2002-11-29 GLP: yes Not published 1978 IIA Acute Toxicity of Technical Glyphosate (AB-78- BAY M-646029-01-2 8.3.1.1/01 201) to Daphnia magna gbjteziGzj enc぀JlRlpt-2 z6i9`täJ.TkIä 4a(,. Rni゗z_1j. J3§ねtJ)/ g9・72, USA Report No: AB 78-201 Date: 1978-08-31 GLP: no not published

1999 IIA Avian Single-Dose Acute Oral Toxicity Test in NUF 8.1.1/03 Japanese Quail with the chemical product じi/ョléIJ? zLaz9lh ロ`4ä!龽 `UACÄC- ゕGイ`PZヌACZBダ G,ZZO: Pcczp8? Tdééb kj/C0é, Brasil Report No: D8.1 – 382/99 Date: 1999-12-20 GLP: no not published 2011 IIA AMPA (Aminomethylphosphonic acid): An early GTF 8.2.4./02 life-stage toxicity test with the fathead minnow (Pimephales promelas) lj3Wt/`c a)§:゛$zr゜j?l/ Tiョ,. pb447 n・L?Jj. みcjx(ョe・, USA Report No: WL-2010-328 Date: 2011-06-16 GLP: yes not published

Page 138 of 192

- 139 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2011 IIA AMPA (Aminomethylphosphonic acid): A semi- GTF 8.3.2.1/02 static life cycle toxicity test with the Cladoceran (Daphnia magna) Wjj3tt!ä lc!y?t7ei!dlk. i.Tく, く_3öv みiäoefo8, USA Report No: WL-2010-327 Date: 2011-06-17 GLP: yes Not published

1996 IIA Glyphosate acid: Acute toxicity to Daphnia SYN 8.3.1.1./04 magna Rldzf9龿 h$!80a0cZ:&/t EeIjö(vöz§. Lzczüa E龾l:t?*. j0e぀.R)2 Ücpy_, UK Report No: BL5551/B Date: 1996-02-22 GLP: yes not published 2000 IIA AMPA: Acute toxicity of AMPA technical SYN 8.9.1/02 material to the earthworm Eisenia andrei in an artificial soil test TBL ä3o/dtcX$l0oöi゛龿0ダV. J§Ptdfaj龾, Germany Report No: F13RA Date: 2000-09-13 GLP: yes Not published

2002 IIA AMPA Earthworm (Eisenia fetida), Effects on FSG 8.9.2/03 Reproduction f,ダ V5?・!v-l龼eEz9e3)/3 f!v Äü?Yp:7c8a ゕjyqäi・l. Fej§!Jcl, Germany Report No: 011120FB Date: 2002-06-05 GLP: yes Not published

1996 IIA Glyphosate: Acute Oral Toxicity to Japanese NUF 8.1.1/02 Quail n(lpR57 しe:cäi3u Lx゛a-.fI_ H3Iiq H*Jü)?`gl Üロu StO, UK Report No: 1413/4-1011 Date: 1996-07-23 GLP: yes Not published

1996 IIA Glyphosate: Acute Oral Toxicity to Mallard Duck NUF 8.1.1./04 ゕ!1nl6ö O??/vai6 ゛-8§-.fTc ダ*(くi イJ4-zk-6t ヌ1ロ /Fダ, UK Report No: 1413/5-1011 Date: 1996-07-18 GLP: yes Not published

Page 139 of 192

- 140 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2003 IIA MON 78623: A 96-hour Static Acute Toxicity BAY M-646028-01-2 8.2.1/07 Test with the Rainbow Trout (Oncorhynchus mykiss) /3:/?W:) )!.gja4ci:buct k,Zl. yh30 B5&äIzc゘ Äj?(く. L?J:.h5 ねe-ö?$j3 6gn*g, USA Report No: WL-2002-149 Date: 2003-08-28 GLP: no not published 2003 IIA MON 78623: A 48-Hour Static Acute Toxicity BAY M-645481-01-2 8.3.1.1/07 Test with the Cladoceran (Daphnia magna) llW/üt-a `ä)ziju2ä:.くi0 Z,.:§ öq42 ゛&!R぀?e? tö?UI. eiü.TJ0 ねf:78cpe ョ゜d$k, USA Report No: WL-2002-150 Date: 2003-05-01 GLP: no not published

2011 IIA HMPA (Hydroxymethylphosphonic acid): A 48- GTF 8.3.1.1./09 hour static acute toxicity test with the cladoceran (Daphnia magna) Wjzjiq/( `lc5xö`cilxei b.T:, LedJj7. ヸK, USA Report No: WL-2010-329 Date: 2011-03-29 GLP: yes not published

2011 IIA 8.4/11 HMPA (hydroxymethylphosphonic acid): A 72- GTF Hour Toxicity Test with the Freshwater Alga (Pseudokirchneriella subcapitata) :゛j-zW:i 3z*ir:`z:62zj. Tjョ. Lj5.zJ$ ね:z゛c-7v ön5y4 USA Report No: 139A-396A Date: 2011-10-11 GLP: yes not published

2011 AII 8.6/06 HMPA (hydroxymethylphosphonic acid): A 7- GTF Day Static-Renewal Toxicity Test with Duckweed (Lemna gibba G3) Wjt/-i_a f8bäjüe:/?)l8. ョZ/. Lu.äJi8 みe(jö0ep ゜2ョ67 USA Report No: 139A-397 Date: 2011-10-11 GLP: yes not published

1999 AII 8.6/02 Glyphosate 62% IPA-Salt, Aquatic Plant toxicity FSG Test using Lemna gibba Q-, Hzョ?(ü`4ä!Z1öcjj5龽 1)r k゛äzppcダQ: Rt4t゛くlä. fJ?Fäiyi. Germany Report No: 980909FH Date: 1999-02-12 GLP: yes not published

Page 140 of 192

- 141 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2010 IIA Residues of glyphosate in arthropods after spray GTF 8.16.2./01 application in an arable field – magnitude and time course of residue decline ゕ-SくR7 w゘_V. at5a)yイ:5z, Germany Report No: 10153 Date: 2010-12-14 GLP: yes not published

2009 IIA MON0139 – Effects on the reproduction of the GTF 8.9.2/05 predatory mite Hypoaspis aculeifer 1ゕlBvä゗ äcu(). ku(Zä `p` t/la0_§゛Jä8 0bq eä・3z龿/Jä ロ§cj2jt* イuU龽. X2J)hz1Iä- lc v. 2gョ9゛ äJ?H-tzu_:k. Germany Report No: 09 10 48 058 S Date: 2009-12-18 GLP: yes 2010 IIA AM PA – Effects on the GTF 8.9.2/07 Reproduction of the Predatory Mite Hypoaspis aculeifer Bjß龽ゕ8a z!.?4- Eäuh- rbI ot く5゛jJzt4? $ßb e3?/e龽Jßä Ü?i*jvく/ DH龿3. k2?I:(?イ- Jb? y. 7d゜ßn eJt9X?`:ü*z. Germany Report No: 10 10 48 053 S Date: 2010-09-07 2010 IIA AMPA - Effects on the Activity of Soil Microflora GTF 8.10.1/02 (Nitrogen and Carbon Transformation Tests) pゕゕ/öa龼 ?!`$ä. Zcq!h r6- 5kく:a゜/ntJz ゜ 7く぀tJeävc4z ョtblÖc/6 V龽uヌ. c:゜yäH- ?Jt§. Germany Report No: 10 10 48 010 C/N Date: 2010-10-07 GLP: yes not published

2003 IIA Laboratory determination of the side-effects of ALS 8.9.2/04 aminomethyl phosphonic acid (AMPA) on the reproductive performance of earthworms (Eisenia fetida) using artificial soil substrate ゛ppJFjerä Jä.,,),i, ?kF. France Report No: 01-64-077-ES Date: 2003-01-20 GLP: yes Not published 1996 AII 8.6/01 GLYPHOSATE ACID: Toxicity to duckweed SYN (Lemna gibba) jp龽R)゛c Z(くäkn/く龿a゜/j Tklxpe1`?I. HLBLTN :&tjg.Tä e぀R-tü・イä*21 Eじo ダ.qC UK Report No: BL5662/B Date: 1996-01-31 GLP: yes not published

Page 141 of 192

- 142 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1996 IIA 8.4/06 Glyphosate acid: Toxicity to freshwater diatom SYN Navicula pelliculosa CIj9cb& _)ä4Tく:_g龾/ät ü)e3Täqi5` Ec3aee E:aョl゗i. ?g.X$ü UK Report No: BL5673/B Date: 1996-11-10 GLP: yes not published 1995 IIA 8.4/02 Glyphosate acid: Toxicity to the green alga SYN Selenastrum capricornutum Cte龿-5v Z72龿?/ョ/)4uc/ Zhdc8fzj!゜ Eäz?äü ゗:T:/z0. zョÄョ*. UK Report No: BL5550/B Date: 1995-12-12 GLP: yes not published

1996 IIA 8.4/04 Glyphosate acid: Toxicity to the marine alga SYN Skeletonema costatum )゗Cldbz xf25:Zxlp&c?/ T?xi` くn!äp Eäoaää t゜.T゘:l? Äョg?3, UK Report No: BL5684/B Date: 1996-11-08 GLP: yes not published 1996 IIA 8.4/03 Glyphosate acid: Toxicity to blue-green alga SYN Anabaena flos-aquae 0ä぀ゕ(tü Zkt_hiäi゜`ö&a Te ゛cp(・8Il ä5eTaa T぀/jhja. A9k.äö UK Report No: BL5698/B Date: 1996-11-08 GLP: yes not published 2010 IIA An extended laboratory test to determine the BAY M-646575-01-2 8.8.2.3/01 effects of MON 52276 on the ground-active beetle, Aleochara bilineata (Coleoptera, Staphylinidae) 龿ö(5くみedL T,i゛. 6*zgF$l぀i・ョ, UK Report No: MON-09-4 (MT-2009-403) Date: 2010-04-27 GLP: yes not published

2010 IIA A rate-response extended laboratory test to BAY M-646874-01-2 8.8.2.1/01 determine the effects of MON 52276 on the parasitic wasp, Aphidius rhopalosiphi (Hymenoptera, Braconidae) ev§)Lu・み& T,i2. Fj36:・゜゛e龼§, UK Report No: MON-09-2 (MT-2009-405) Date: 2010-04-27 GLP: yes not published

Page 142 of 192

- 143 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

1998 IIA Glyphosate Acid: Acute Contact and Oral Toxicity SYN 8.7.1/03 to Honey Bees (Apis mellifera) z:゛zUj4t Ca? .ヌ II A 8.7.2 p:/ zIR9/äi Fejä?4e Tcäf.nk`i*g F゜äx l:7Öhョ. D ゜d`, UK Report No: FN9700 Date: 1998-12-04 GLP: yes not published

2011 IIA Glyphosate: Study to determine potential exposure GTF 8.7.3/01 of honeybee colonies to residues under semi-field conditions Lua Suvö ?くp ゛:!na6j?Zh゛龽: ゕJcz?4aI V1ae.qp cF§5 Yoij7ョ. gI.じ_ U.K. Report No: V7YH1002 Date: 2011-12-21 GLP: yes not published

2012 IIA Glyphosate: Evaluating potential effects on GTF 8.7.4/01 honeybee brood (Apis mellifera) development E9z P957 öä゜ Z9(u゘?/ztb/くg C?z5aJc( cg.Y8§z ?öFü 1/1じ:$. A!n$. U.K. Report No: V7YH1001 Date: 2012-01-27 GLP: yes not published

2002 IIA 8.6/03 IPA Salt of Glyphosate: Effects on Lemna SIN minor ゕTヸ öi??iHctol F?5?z(/J ,.El・ `J/.R?4゜ )z L9?§bgj, U.K. Report No: CEMR-1873 Date: not stated GLP: yes Not published

1995 IIA Honey Bees (Apis mellifera L.), oral toxicity study AGC 8.7.1/04 in the laboratory with Glyphosate ダKLDイ X.C, a-hgbJäxイip?2, The Netherlands Report No: 141907 Date: 1995-09-22 GLP: yes not published

1995 IIA Honey Bees (Apis mellifera L.), contact toxicity AGC 8.7.1/05 study in the laboratory with Glyphosate ダÜZイÄ II A 8.7.2 R,N. qö_3 KÖ `z(i0ä26qJ'Jし$?く, The Netherlands Report No: 142335 Date: 1995-09-22 GLP: yes not published

Page 143 of 192

- 144 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number reference Report No. number Date GLP status, published or not

2012 AII 8.6/04 Effect of MON77973 (Glyphosate acid) on the GTF Growth of Myriophyllum aquaticum in the Presence of Sediment. Test with a subsequent Recovery Period. `e§§5c`r!Ji/P§(゜jöjc (8- ョc§i?(れta C゜ihjü6 äb$ Äotlchく Lä1:゛12 !-fヸL. §8g*xロ( Fu぀:・ *z?jcnä), Germany Report No: CHE-015/4-80/A Date: 2012-02-21 GLP: yes Not published

2012 AII 8.6/05 Effect of AMPA (Aminomethylphosphonic acid) on GTF the Growth of Myriophyllum aquaticum in the Presence of Sediment, with a subsequent Recovery Period, including Amendment No 2 Sz68*(・/4`§r?`)J:/ia 4I) ねtä4/く?z` R1i・゛0j zョü ロqicxtk Ta/v2xx (f-ヸZ. しI6k919 Fq:z$afz龿etn3, Germany Report No: CHE-022/4-80/A Date: 2012-02-12 GLP: yes Not published

2006 IIA Glyphosate Technical: Acute Toxicity to NUF 8.2.1/04 Common Carp (Cyprinus carpio) Fer8!z_c龽く)äjzEäy゛I/J jlc.E/龾゛ NäJö?.!vk/) OL$3 しイ゛, UK Report No: 2060/015 Date: 2006-01-03 GLP: Yes not published

1996 IIA Glyphosate: Acute contact and oral toxicity to NUF, CHE 8.7.1/02 honeybees. II A 8.7.2 8f/゛Bph Vaijkäcü -*z(T7f5. Nef゜.`n?/? ゛kヌfi 7-fc.ロxJ・j UK Report No: 1413/3-1018 Date: 1996-08-14 GLP: yes not published

1990 IIA Assessment of the acute toxicity of glyphosate CHE 8.15/02 technical on aerobic waste-water bacteria CRR ?/i?7゗/ダ龽Ü?a Dロ $ky6 r:.l・3c$ Switzerland Report No: 277830 Date: 1990-10-17 GLP: yes Published

1990 IIA 48-Hour Acute Toxicity of GLYPHOSATE CHE 8.3.1.1/02 TECHNICAL to Daphnia magna (OECD- Immobilization Test) RCB QれLÜれTWZZゕTf XX. `gqkRイh rl5cpix, Switzerland Report No: 272968 Date: 1990-11-09 GLP: yes Not published

Page 144 of 192

- 145 - Glyphosate –List of tests and studies Ecotoxicology

4.2 Ecotoxicology – Representative formulation

Year Annex Title Owner Bayer Document point/ Source -Company name Number referenc Repor e t No. number Date GLP status, published or not

2001 IIIA Laboratory bioassays to determine acute oral BAY M-646576-02-3 10.4.2./01 and contact toxicity of MON 52276 to the honeybee, Apis mellifera ヸcpq9龿!Zy /Ek. ilゕeJJ? -a2RaJ?l LzJl. P:゗bq8o゛?$: Pdbn Fじ9, UK Report No: MON-00-2 version 2 Date: 2001- 01-08 GL 2002 AIII Assess ment of toxic effects of MON 52276 on BAY M-646121-01-2 10.8.2.1/01 aquatic plants using the duckweed Lemna gibba ダゕじ lz1/aRkjä*0くbl Vし゗く. !じja(ä(ö YJ4)$ä?:7 く0, Germany Report No: GA-2002-051 Date: 2002-11-18 GLP: yes not published 1992* IIIA MON 52276: An acute study with the BAY M-646574-01-2 10.6.2/01 earthworm in an artificial soil substrate. :0tW:t(c :ä)?/3i!§4iyc x,Ti Z0y.äJi 4täd2. みcf USA Report No: 139-306 Date: 1992-09-18 GLP: yes Not published

2011 IIIA MON 52276: Effect on Soil Microbial GTF 10.7.1/01 Activity, Carbon and Nitrogen Transformations RLれ U?h?jョj/ä: P:zJa)nä E:龽:j?4 rTwR れFf Q/ä7ehjc -.S?0 R!_l.zJb!a UK Report No: CEMR-5259 Date: 2012-01-26 GLP: yes 1992* IIIA MON 52276: Acute toxicity to rainbow trout, BAY M-646461-01-2 10.2.2.1/01 Oncorhynchus mykiss, under flow-through test conditions ゛4/?・$L §/`§d龼tT1?゜:e l?JFzpzz. ?.s5yji- i_t0P`ä 2pョ゜゜, USA Report No: TO-91-296 Date: 1992-01-23 GLP: yes 1992* IIIA MON 52276: Acute toxicity to the common BAY M-646460-01-2 10.2.2.1/02 carp, Cyprinus carpio, under flow-through test conditions. *oEp:z・ L*3jnョa7f&/z/ Fäl5?aJa. süq/:ä-. S゜ I?/tk _xb$h, USA Report No: TO-91-298 Date: 1992-01-24 GLP: yes not published

Page 145 of 192

- 146 - Glyphosate –List of tests and studies Ecotoxicology Year Annex Title Owner Bayer Document point/ Source -Company name Number referenc Repor e t No. number Date GLP status, published or not

1992* IIIA MON 52276: Acute toxicity to the water BAY M-646459-01-2 10.2.2.2./0 flea, Daphnia magna, under flow-through 1 test conditions Eh?n/vp qj)?Lkn3぀äqi/ Pätc*Jza. shl.q/z` /b!Pl0ä, USA Report No: TO-91-295 Date: 1992-01-23 GLP: yes Not published

1992* IIIA A1ga, Growth Inhibition Test Effect of MON BAY M-646122-01-2 10.2.2.3./0 52276 on The Growth Of 1 Selenastrum capricornutum ZrLFゕ. k4Cfok ?1Aö Belgium Report No: LI-91-389 Date: 1992-01-10 GLP: yes Not published

2012 AIII Effect of MON52276 (Glyphosate formulation) GTF 10.8.2.1/02 on the Growth of Myriophyllum aquaticum in the Presence of Sediment, with a subsequent Recovery Period. S(゜p()Jilvieod?-)6lä 3() ヸga:iäücf ゛1ゕj:_u dcu 0ijw・äv ・_゛Tej8 !-Z. み` nbAf5yo ョ龿/:6P?ääkga-, Germany Report No: CHE-016/4-80/A Date: 2012-02-24

Page 146 of 192

- 147 - Glyphosate –List of tests and studies Ecotoxicology

4.3 List of all Other/Special Studies in Section IIA 8.16

A list of all Other/Special Studies in Section IIA 8.16 is presented in three tables in the following pages:

Table 1. Studies conducted by the Glyphosate Task Force or member companies in support of the submission Annex Year Title Owner Bayer Document point/ Source (where different from Number reference company), Company name number Report No. Date GLP status (where relevant) published or not

IIA 8.16.1/01 2012 Comparative Post-Emergence Phytotoxicity BAY M-651389-01-2 of AMPA and Glyphosate to Crop and Annual Weed Species yJ§lnみqz v8Bく゘$?. lP, EJ§くj, Missouri, 63167, USA Report No: MSL0024009 Date: 2012-04-10 GLP: no Not published IIA 8.16.2/01 2010 Residues of glyphosate in arthropods after GTF spray application in an arable field – magnitude and time course of residue decline P1qゕ)B ゗uÄK. ?jv.ロat*・z` Germany Report No: 10153 Date: 2010-12-14 GLP: yes not published

Page 147 of 192

- 148 - Glyphosate –List of tests and studies Ecotoxicology

Table 2. Relevant glyphosate literature Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Abrantes N, Pereira R, de 2009 A Whole Sample Toxicity Assessment to Evaluate 1 Figueiredo DR, Marques the Sub-Lethal Toxicity of Water and Sediment CR, Pereira MJ, Elutriates from a Lake Goncalves F Exposed to Diffuse Pollution. Environmental Toxicology 24 (3):259-270. Doi 10.1002/Tox.20428.

IIA 8.16 Accinelli C, Screpanti C, 2002 Short-time effects of pure and formulated herbicides 1 Dinelli G, Vicari A on soil microbial activity and biomass. International Journal of Environ- mental Analytical Chemistry 82 (8-9):519- 527. Doi 10.1080/03067310290009514.

IIA 8.16 Achiorno CL, de 2008 Toxicity of the herbicide glyphosate to 3 K Villalobos C, Ferrari L Chordodes nobilii (Gordiida, Nematomorpha). Chemosphere 71 (10):1816-1822. DOI 10.1016/j.chemosphere.2008.02.001.

IIA 8.16 Addison PJ, Barker 2006 Effect of various pesticides on the non-target species 1 GM Microctonus hyperodae, a biological control agent of Listronotus bonariensis. Entomologia Experimentalis Et Applicata 119 (1):71-79

IIA 8.16 Ahemad M, Khan 2011 Ecotoxicological assessment of pesticides towards the 1 MS plant growth promoting activities of Lentil (Lensesculentus)-specific Rhizobium sp. strain MRL3 Ecotoxicology 20 (4):661-669. DOI: 10.1007/s10646-011- 0606-4.

IIA 8.16 Ahemad M, Khan 2011 Effect of Pesticides on Plant Growth Promoting 1 MS Traits of Greengram-Symbiont, Bradyrhizobium sp. strain MRM6 Bulletin of Environmental Contamination and Toxicology 86 (4):384-388. doi: 10.1007/s00128-011-0231-1.

IIA 8.16 Ahemad M, Khan 2012 Effects of pesticides on plant growth promoting 1 MS traits of Mesorhizobium strain MRC4. Journal of the Saudi Society of Agricultural Sciences 11 (1):63-71. doi: 10.1016/j.jssas.2011.10.001.

IIA 8.16 Ahemad M, Khan 2011 Toxicological assessment of selective pesticides 1 MS towards plant growth promoting activities of phosphate solubilizing Pseudomonas aeruginosa. Acta Microbiolo- gica et Immunologica Hungarica 58 (3):169- 187. doi: 10.1556/AMicr.58.2011.3.1.

IIA 8.16 Ahemad M, Khan 2011 Toxicological Effects of Selective Herbicides on Plant 1 MS Growth Promoting Activities of Phosphate Solubilizing Klebsiella sp. Strain PS19. Current Microbi- ology 62 (2):532-538. doi: 10.1007/s00284- 010-9740-0.

Page 148 of 192

- 149 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Ainsworth N 2003 Integration of herbicides with arthropod biocontrol 1 agents for weed control. Bio- control Science and Technology 13 (6):547- 570. Doi 10.1080/0958315031000151819.

IIA 8.16 Akcha F, Spagnol C, 2012 Genotoxicity of diuron and glyphosate in oyster 1 Also listed Rouxel J spermatozoa and embryos. Aquatic toxicology under (Amsterdam, Netherlands) 106- IIA 5.10 107:104-13. doi:10.1016/j.aquatox.2011.10.018.

IIA 8.16 Albajes R, Lumbierres 2011 Two heteropteran predators in relation to weed 1 B, Pons X management in herbicide-tolerant corn. Biological Control 59 (1):30-36. DOI 10.1016/j.biocontrol.2011.03.008.

IIA 8.16 Ali MI, Gharieb 2002 The Effect Of Copper Oxychloride Fungicide or 1 MM, El-Shoura AA Glyphosate Herbicide On Gypsum Solubilization Activity Of Certain Soil Fungi. African Journal of Mycology and Biotechnology 11 (1):A207-A224

IIA 8.16 Al-Khatib K, Claas- sen 2003 Grain sorghum response to simulated drift from 1 MM, Stahlman PW, Geier glufosinate, glyphosate, imazethapyr, and PW, Re- gehr DL, Duncan sethoxydim. Weed Technology 17 (2):261-265 SR, Heer WF

IIA 8.16 Alvarez-Moya C, Silva 2011 Evaluation of genetic damage induced by glyphosate 3 (8.16) K Also listed MR, Arambula ARV, isopropylamine salt using Tradescantia bioassays. 2 (5.10) under Sandoval AI, Vasquez Genetics and Mole- cular Biology 34 (1):127-130 IIA 5.10 HC, Montes RMG

IIA 8.16 Amoros I, Alonso JL, 2007 Assessment of toxicity of a glyphosate-based 2 Romaguera S, Carrasco formulation using bacterial systems in lake water. JM Chemosphere 67 (11):2221-2228. DOI 10.1016/j.chemosphere.2006.12.020.

IIA 8.16 Anderson JA, Kol- mer 2005 Rust control in glyphosate tolerant wheat 1 JA following application of the herbicide glyphosate. Plant Disease 89 (11):1136- 1142. Doi 10.1094/Pd-89-1136.

IIA 8.16 Andréa MM, Papini S, 2004 Glyphosate: influence on the soil bioactivity and 1 Also listed Peres TB, Bazarin S, action of earthworms on its soil dissipation. . Planta under Savoy VLT, Matallo MB Daninha 22:95-100. DOI: 10.1590/S0100- IIA 7.13 83582004000100012.

IIA 8.16 Antunes SC, Pereira JL, 2010 Structural effects of the bioavailable fraction of 1 Cachada A, Duarte AC, pesticides in soil: Suitability of elutriate testing. Goncalves F, Sousa JP, Journal of Hazardous Materials 184 (1-3):215-225. Pereira R DOI 10.1016/j.jhazmat.2010.08.025.

IIA 8.16 Araujo ASF, 2003 Effect of glyphosate on the microbial 1 Monteiro RTR, activity of two Brazilian soils. Chemosphere Abarkeli RB 52 (5):799-804. Doi 10.1016/S0045- 6535(03)00266-2.

IIA 8.16 Arfarita N, Imai T, Kanno 2011 Screening of Soil-Born Fungi from Forest Soil Using 1 A, Higuchi T, Yamamoto Glyphosate Herbicide as the Sole Source of K, Sekine M Phosphorus. Journal of Water and Environment Technology 9 (4):391-400. doi: 10.2965/jwet.2011.391.

Page 149 of 192

- 150 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Ayoola SO 2008 Histopathological Effects of Glyphosate on Juvenile 2 African Catfish (Clarias gariepinus). American- Eurasian J. Agric. & Environ. Sci. 4 (3):362-367

IIA 8.16 Ayoola SO 2008 Toxicity of glyphosate herbicide on Nile tilapia 2 (Oreochromis niloticus) juvenile. African Journal of Agricultural Research 3 (12):825-834

IIA 8.16 Babiker EM, Hulbert SH, 2011 Optimum Timing of Preplant Applications of 2 Schroeder KL, Paulitz TC Glyphosate to Manage Rhizoctonia Root Rot in Barley. Plant Disease 95 (3):304-310. doi: 10.1094/pdis-05-10-0354.

IIA 8.16 Baley GJ, Campbell KG, 2009 Influence of glyphosate, crop volunteer and root 1 Yenish J, Kidwell KK, pathogens on glyphosate-resistant wheat under Paulitz TC controlled environmental conditions. Pest Manag Sci 65 (3):288-99. DOI: 10.1002/ps.1687.

IIA 8.16 Barbukho OV, Zhy- 2011 Effect of Herbicide "Roundup" on Viability of the 1 denko AO Carp Eggs and Possibility of Profylaxis of its Toxic Impact by Probiotic Preparations BPS-44. Hydrobiological Jour- nal 47 (5):72-76. doi: 10.1615/HydrobJ.v47.i5.70.

IIA 8.16 Barriuso J, Marin S, 2011 Potential Accumulative Effect of the Herbicide 1 Mellado RP Glyphosate on Glyphosate- Tolerant Maize Rhizobacterial Communities over a Three-Year Cultivation Period. Plos One 6 (11):e27558. doi: 10.1371/journal.pone.0027558. IIA 8.16 Barriuso J, Marin S, 2010 Effect of the herbicide glyphosate on glyphosate- 2 Mellado RP tolerant maize rhizobacterial communities: a comparison with pre- emergency applied herbicide consisting of a combination of acetochlor and terbuthylazine. Environ Microbiol 12 (4):1021-30. DOI: 10.1111/j.1462- 2920.2009.02146.x.

IIA 8.16 Barriuso J, Mellado 2012 Relative Effect of Glyphosate on Glyphosate-Tolerant 1 RP Maize Rhizobacterial Communities is Not Altered by Soil Properties. J. Microbiol. Biotechnol. 22 (2):159- 165. DOI: 10.4014/jmb.1107.07036.

IIA 8.16 Barriuso J, Valverde 2011 Effect of the Herbicide Glyphosate on the Culturable 1 JR, Mellado RP Fraction of Glyphosate-tolerant Maize Rhizobacterial Communities Using Two Different Growth Media. Microbes and Environments 26 (4):332-338. doi: 10.1264/jsme2.ME11137.

IIA 8.16 Benamu MA, Schneider 2010 Effects of the herbicide glyphosate on biological 3 K MI, San- chez NE attributes of Alpaida veniliae (Araneae, Araneidae), in laboratory. Che- mosphere 78 (7):871-6. DOI: 10.1016/j.chemosphere.2009.11.027.

IIA 8.16 Bennicelli RP, Sza- 2009 Influence of pesticide (glyphosate) on 2 franek-Nakonieczna A, dehydrogenase activity, pH, Eh and gases Wolinska A, production in soil (laboratory conditions). Stepniewska Z, Bo- International Agrophysics 23 (2):117-122 gudzinska M

Page 150 of 192

- 151 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Bernal MH, Solomon 2009 Toxicity of formulated glyphosate (glyphos) and 1 KR, Carrasquilla G cosmo-flux to larval and juvenile colombian frogs 2. Field and laboratory microcosm acute toxicity. J Toxicol Environ Health A 72 (15):966-73. DOI: 10.1080/15287390902929717.

IIA 8.16 Bernal MH, Solomon 2009 Toxicity of formulated glyphosate (glyphos) and 1 KR, Carrasquilla G cosmo-flux to larval Colombian frogs 1. Laboratory acute toxicity. J Toxicol Environ Health A 72 (15):961-5. DOI: 10.1080/15287390902929709.

IIA 8.16 Bernard MB, Cole P, 2010 Reducing the Impact of Pesticides on Biological 2 Kobelt A, Horne PA, Control in Australian Vineyards: Pesticide Mortality Altmann J, Wratten SD, and Fecundity Effects on an Indicator Species, the Yen AL Predatory Mite Euseius victoriensis (Acari: Phytoseiidae). Journal of Economic Entomology 103 (6):2061-2071. Doi 10.1603/Ec09357.

IIA 8.16 Bérubé M-E, Vanasse A, 2012 Effect of Glyphosate on Fusarium Head Blight in 1 Rioux S, Bourget N, Dion Wheat and Barley Under Different Soil Tillages. Y, Tremblay G Plant Disease 96 (3):338-344. DOI: 10.1094/pdis-04- 11-0297.

IIA 8.16 Blackburn LG, Bou- tin 2003 Subtle effects of herbicide use in the context of 3 K C genetically modified crops: A case study with glyphosate (Roundup (R)). Ecotoxico- logy 12 (1- 4):271-285

IIA 8.16 Blazier MA, Hennessey 2005 Effects of fertilization and vegetation control on 1 TC, Deng SP microbial biomass carbon and dehydrogenase activity in a juvenile loblolly pine plantation. Forest Science 51 (5):449- 459

IIA 8.16 Bohm GMB, Alves BJR, 2009 Glyphosate- and imazethapyr-induced effects on 2 Urquiaga S, Boddey RM, yield, nodule mass and biological nitrogen fixation in Xavier GR, Hax F, field-grown glyphosate- resistant soybean. Soil Rombal- di CV Biology & Bioche- mistry 41 (2):420-422. DOI 10.1016/j.soilbio.2008.11.002.

IIA 8.16 Bohm GMB, Sche- 2011 Weed control, biomass and microbial metabolism of 1 neider L, Castilhos D, soil depending on the application of glyphosate and Agostinetto D, imazethapyr Rombaldi CV on crop soybeans. Semina: Ciencias Agrarias (Londrina) 32 (3):919-930

IIA 8.16 Botelho AAA, Mon- teiro 2011 Sensitivity of entomopathogenic fungi to pesticides 1 AC used in management of sugarcane. Bragantia 70 (2):361-369 IIA 8.16 Boutin C, Elmegaard 2004 Toxicity testing of fifteen non-crop plant species with 3 K N, Kjaer C six herbicides in a greenhouse experiment: Implications for risk assessment. Ecotoxicology 13 (4):349-369

IIA 8.16 Boutin C, White AL, 2010 Measuring variability in phytotoxicity testing using 3 K Carpenter D crop and wild plant species. Environmental Toxicology and Chemistry 29 (2):327-337. DOI: 10.1002/etc.30.

Page 151 of 192

- 152 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Brain RA, Solomon 2009 Comparison of the hazards posed to amphibians by 1 KR the glyphosate spray control program versus the chemical and physical activities of coca production in Colombia. J Toxicol Environ Health A 72 (15):937-48. DOI: 10.1080/15287390902929683.

IIA 8.16 Brausch JM, Beall B, 2007 Acute and sub-lethal toxicity of three POEA 3 K Smith PN surfactant formulations to Daphnia magna. Bulletin of Environmental Contamination and Toxicology 78 (6):510-514. DOI 10.1007/s00128-007-9091-0.

IIA 8.16 Brausch JM, Cox S, 2006 Pesticide usage on the Southern High Plains and 3 K Smith PN acute toxicity of four chemicals to the fairy shrimp Thamnocephalus platyurus (Crustacea: Anostraca). The Texas Journal of Science 58 (4):309-324 IIA 8.16 Brausch JM, Smith 2007 Toxicity of three polyethoxylated tallowamine 3 K PN surfactant formulations to laboratory and field collected fairy shrimp, Thamnocephalus platyurus. Archives of Environmental Contamination and Toxico- logy 52 (2):217-221. DOI 10.1007/s00244- 006-0151-y. IIA 8.16 Bringolf RB, Cope WG, 2007 Acute and chronic toxicity of glyphosate compounds 3 K Mosher S, Barnhart to glochidia and juveniles of Lampsilis siliquoidea MC, Shea D (Unionidae). Environ Toxicol Chem 26 (10):2094- 100. DOI: 10.1897/06-519R1.1.

IIA 8.16 Brodman R, New- man 2010 Interaction of an Aquatic Herbicide and Predatory 3 K WD, Laurie K, Osterfeld Salamander Density on Wetland Communities. S, Lenzo N Journal of Herpetology 44 (1):69-82

IIA 8.16 Brown LR, Robinson 2009 Response of Corn to Simulated Glyphosate Drift 1 DE, Young BG, Loux Followed by In-Crop Herbicides. Weed Technology MM, Johnson WG, 23 (1):11-16. Doi 10.1614/Wt- Nurse RE, Swanton CJ, 08-067.1. Sikkema PH IIA 8.16 Brown PB, Wilson KA, 2003 Glyphosate tolerant canola meal is equivalent to the 1 Jonker Y, Nick- son TE parental line in diets fed to rainbow trout. Journal of Agricultural and Food Chemistry 51 (15):4268-4272. Doi 10.1021/Jf034018f.

IIA 8.16 Bueno AD, Bueno 2008 Effects of pesticides used in soybean crops to the 1 RCOD, Parra JRP, egg parasitoid Trichogramma pretiosum. Ciencia Vieira SS Rural 38 (6):1495-1503 IIA 8.16 Busse MD, Ratcliff 2001 Glyphosate toxicity and the effects of long- term 1 AW, Shestak CJ, vegetation control on soil microbial communities. Powers RF Soil Biology & Biochemistry 33 (12-13):1777-1789

IIA 8.16 Carmo ELd, Bueno AdF, 2009 Selectivity of different pesticides used in soybean 1 Bueno RCOdF, Vieira SS, to the eggs parasitoid Telenomus remus. Ciência Gobbi AL, Vasco FR Rural 39:2293-2300

IIA 8.16 Carmo ELd, Bueno AF, 2010 Selectivity of pesticides used in soybean crops to 1 Bueno RCOF, Vieira Trichogramma pretiosum Riley, SS, Goulart MMP, 1879 (Hymenoptera: Trichogrammatidae) pupae. Carneiro TR Arq. Inst. Biol., São Paulo 77 (2):283-290

Page 152 of 192

- 153 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Casabe N, Piola L, Fuchs 2007 Ecotoxicological assessment of the effects of 2 J, Oneto ML, Pamparato glyphosate and chlorpyrifos in an Argentine soya field. L, Basack S, Gimenez R, Journal of Soils and Sediments 7 (4):232-239. DOI Massaro R, Papa JC, 10.1065/jss2007.04.224. Kesten E

IIA 8.16 Castilhos RV, 2011 Selectivity of Pesticides Used in Peach Orchard on 1 Grutzmacher AD, Nava Adults of Chrysoperla Externa (Hagen, 1861) DE, Zotti MJ, Siqueira (Neuroptera: Chrysopidae). Revista Brasileira De PRB Fruticultura 33 (1):73- 80

IIA 8.16 Castilla AM, Dauwe T, 2010 Nitrates and Herbicides Cause Higher Mortality than 2 Mora I, Malone J, Guitart the Traditional Organic Fertilizers on the Grain R Beetle, Tenebrio molitor. Bulletin of Environmental Contami- nation and Toxicology 84 (1):101-105. DOI 10.1007/s00128-009-9883-5.

IIA 8.16 Castilla AM, Dauwe T, 2008 Mortality of the yellow mealworm Tenebrio molitor 2 Mora I, Palmer M, Guitart exposed to fertilizers and herbicides commonly used R in agriculture. Vie et Milieu - Life and Environment 58 (3/4):243-247

IIA 8.16 Castro Jr. JV, Sel- bach 2006 Evaluation of the effect of herbicide glyphosate on 1 PA, Zachiaayub MA soil microbiota. Pesticidas: R. Ecotoxicol. E. Meio Ambiente, Curitiba 16:21-30

IIA 8.16 Castro JV, Peralba 2007 Biodegradation of the herbicide glyphosate by 1 Also listed MCR, Ayub MAZ filamentous fungi in platform shaker and batch under bioreactor. Journal of Environmental Science and IIA 7.13 Health Part B-Pesticides Food Contaminants and Agricultural Wastes 42 (8):883-886. Doi 10.1080/03601230701623290.

IIA 8.16 Cattaneo R, Clasen B, 2011 Toxicological Responses of Cyprinus carpio Exposed 2 Loro VL, de Menezes to a Commercial Formulation Containing Glyphosate. CC, Pretto A, Bulletin of Envi- ronmental Contamination and Baldisserotto B, Santi Toxicology 87 (6):597-602. doi: 10.1007/s00128-011- AL, de Avila LA 0396- 7.

IIA 8.16 Cauble K, Wagner 2005 Sublethal effects of the herbicide glyphosate on 3 K RS amphibian metamorphosis and development. Bulletin of Environmental Contamination and Toxicology 75 (3):429- 435. DOI 10.1007/s00128-005-0771-3.

IIA 8.16 Cavalcante DGSM, 2008 Genotoxic effects of Roundup (R) on the fish 1 (8.16) Also listed Martinez CBR, Sofia SH Prochilodus lineatus. Mutation Research-Genetic 2 (5.10) under Toxicology and Environmental Mutagenesis 655 IIA 5.10 (1-2):41- 46. DOI 10.1016/j.mrgentox.2008.06.010.

IIA 8.16 Cavas T, Konen S 2007 Detection of cytogenetic and DNA damage in 2 (8.16) K Also listed peripheral erythrocytes of goldfish (Carassius 3 (5.10) under auratus) exposed to a glyphosate formulation using E IIA 5.10 the micronucleus test and the comet assay. Mutagenesis 22 (4):263-8. DOI: 10.1093/mutage/gem012.

IIA 8.16 Cedergreen N, Ole- sen 2010 Can glyphosate stimulate photosynthesis? Pesticide 1 CF Biochemistry and Physiology 96 (3):140-148. DOI 10.1016/j.pestbp.2009.11.002.

Page 153 of 192

- 154 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Cedergreen N, Strei- big 2005 The toxicity of herbicides to non-target aquatic plants 1 JC and algae: assessment of predictive factors and hazard. Pest Manage- ment Science 61 (12):1152- 1160. Doi 10.1002/Ps.1117.

IIA 8.16 Cerdeira AL, Duke 2006 The current status and environmental impacts of 2 (8.16) Also listed SO glyphosate-resistant crops: a review. J Environ 1 (7.13) under Qual 35 (5):1633-58. DOI: IIA 7.13 10.2134/jeq2005.0378.

IIA 8.16 Cericato L, Machado JG, 2008 Cortisol response to acute stress in jundia Rhamdia 2 Fagundes M, Kreutz LC, quelen acutely exposed to sublethal concentrations Quevedo RM, Finco J, da of agrichemicals. Comparative Biochemistry and Rosa JGS, Koakoski G, Physiology Centenaro L, Pottker E, C-Toxicology & Pharmacology 148 (3):281- Anziliero D, Bar- cellos 286. DOI 10.1016/j.cbpc2008.06.008. LJG IIA 8.16 Cericato L, Neto JGM, 2009 Responsiveness of the interrenal tissue of Jundia 1 Kreutz LC, Quevedo (Rhamdia quelen) to an in vivo ACTH test RM, da Rosa JGS, following acute exposure to sublethal concentrations Koakoski G, Centenaro of agrichemicals. Comparative Biochemistry and L, Pottker E, Marqueze Physiology A, Barcellos LJG C-Toxicology & Pharmacology 149 (3):363- 367. DOI 10.1016/j.cbpc.2008.09.002.

IIA 8.16 Chattopadhyay A, 2007 Influences of environmental factors and antidote 2 Adhikari S, Adhikary SP, addition on glyphosate toxicity to freshwater fish, Ayyappan S Labeo rohita (Hamilton). Chemistry and Ecology 23 (4):279-287. Doi 10.1080/02757540701517845.

IIA 8.16 Chen CY, Hathaway 2004 Multiple stress effects of Vision (R) herbicide, pH, 3 K KM, Folt CL and food on zooplankton and larval amphibian species from forest wetlands. Environmental Toxicology and Chemistry 23 (4):823-831

IIA 8.16 Coler RA, Coler RR, 2005 Applying weight gain in Pomacea lineata (SPIX 1824) 2 Felizardo EK, Watanabe (Mollusca: Prosobranchia) as a measure of herbicide T toxicity. Braz J Biol 65 (4):617-23

IIA 8.16 Comstock BA, Sprinkle 2007 Acute toxic effects of round-up herbicide on wood 3 K SL, Smith GR frog tadpoles (Rana sylvatica). Journal of Freshwater Ecology 22 (4):705-708 IIA 8.16 Conners DE, Black 2004 Evaluation of lethality and genotoxicity in the 2 MC freshwater mussel Utterbackia imbecillis (Bivalvia : Unionidae) exposed singly and in combination to chemicals used in lawn care. Archives of Environmental Contamination and Toxicology 46 (3):362-371. DOI 10.1007/s00244-003-3003-z.

IIA 8.16 Contardo-Jara V, 2009 Bioaccumulation of glyphosate and its formulation 1 Klingelmann E, Wie- Roundup Ultra in Lumbriculus variegatus and its gand C effects on biotransformation and antioxidant enzymes. Environ Pollut 157 (1):57-63. DOI: 10.1016/j.envpol.2008.07.027. IIA 8.16 Correia FV, Moreira 2010 Effects of glyphosate and 2,4-D on earthworms 3 K JC (Eisenia foetida) in laboratory tests. Bull Environ Contam Toxicol 85 (3):264-8. DOI: 10.1007/s00128- 010-0089- 7.

Page 154 of 192

- 155 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Costa MJ, Monteiro DA, 2008 Oxidative stress biomarkers and heart function in 2 Oliveira-Neto AL, Rantin bullfrog tadpoles exposed to Roundup Original FT, Kali- nin AL (R). Ecotoxicology 17 (3):153-163. DOI 10.1007/s10646-007- 0178-5.

IIA 8.16 Cox C, Surgan M 2006 Unidentified inert ingredients in pesticides: 1 Implications for human and environmental health. Environmental Health Perspectives 114 (12):1803-1806

IIA 8.16 Cruz-Hipolito H, Rojano- 2011 Glyphosate tolerance by Clitoria ternatea and 1 Delgado A, Dominguez- Neonotonia wightii plants involves differential Valenzuela JA, Heredia absorption and translocation of the herbicide. Plant A, de Castro MDL, de and Soil 347 (1-2):221- Prado R 230. doi:10.1007/s11104-011-0840-9.

IIA 8.16 Curran CA, Grassley 2004 Toxicity of R-11 (R) surfactant to juvenile rainbow 2 JM, Grue CE trout: Does size matter? Bulletin of Environmental Contamination and Toxico- logy 72 (2):401-408. DOI 10.1007/s00128- 003-0264-1.

IIA 8.16 Cycon M, Kaczynska 2004 Effects of selected pesticides on soil microbial 1 A activity in nitrogen and carbon transformation. Pestycydy 1/2:113-120 IIA 8.16 Daam MA, Van den 2010 Implications of differences between temperate and 1 Brink PJ tropical freshwater ecosystems for the ecological risk assessment of pesticides. Ecotoxicology 19 (1):24-37. DOI 10.1007/s10646-009-0402-6.

IIA 8.16 Dalton RL, Boutin C 2010 Comparison of the effects of glyphosate and atrazine 2 herbicides on nontarget plants grown singly and in microcosms. Environ Toxicol Chem 29 (10):2304-15. DOI: 10.1002/etc.277.

IIA 8.16 Damin V, Franco HCJ, 2008 Nitrogen loss in Brachiaria decumbens after 1 Moraes MF, Franco A, application of glyphosate or glufosinate- ammonium. Trivelin PCO Scientia Agricola 65 (4):402- 407

IIA 8.16 Davis A, Lewis S, 2008 Pesticide Residues In Waterways Of The Lower 1 Bainbridge Z, Brodie J, Burdekin Region: Challenges In Ecotoxicological Shannon E Interpretation Of Monitoring Data. Australasian Journal of Ecotoxicology 14 (2-3):89-108

IIA 8.16 de Alvarez AV, Fuentes 2002 In vitro response of one isolate of Rhizoctonia 1 CL, Torres- Torres E solani, the pathogen of the rice sheath blight and four isolates of Trichoderma to glyphosate. Agronomia Colombiana 19 (1-2):43-55

IIA 8.16 de Jong FMW, de 2001 Development of a field bioassay for the side- effects of 2 Haes HAU herbicides on vascular plants using Brassica napus and Poa annua. Environmen- tal Toxicology 16 (5):397- 407

Page 155 of 192

- 156 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 de Solla SR, Martin 2011 Toxicity of pesticide and fertilizer mixtures 1 PA, Mikoda P simulating corn production to eggs of snapping turtles (Chelydra serpentina). Science of the Total Environment 409 (20):4306-4311. DOI 10.1016/j.scitotenv.2011.06.046.

IIA 8.16 Debenest T, Silvestre 2010 Effects of Pesticides on Freshwater Diatoms. In 1 J, Coste M, Pinelli E Reviews of Environmental Contamination and Toxicology, edited by D. M. Whitacre. Springer New York. pp 87- 103. DOI: 10.1007/978-1-4419-1352-4_2.

IIA 8.16 Deeds ZA, Al-Khatib K, 2006 Wheat Response to Simulated Drift of Glyphosate 1 Peterson DE, Stahlman and Imazamox Applied at Two Growth Stages. Weed PW Technology 20:23-31 IIA 8.16 Demetrio PM, Rossini 2012 Effects of Pesticide Formulations and Active 1 GDB, Bonetto CA, Ingredients on the Coelenterate Hydra attenuata Ronco AE (Pallas, 1766). Bulletin of Envi- ronmental Contamination and Toxicology 88 (1):15-9. doi:10.1007/s00128-011-0463-0.

IIA 8.16 Devos Y, Cougnon M, 2008 Environmental impact of herbicide regimes used 1 Vergucht S, Bul- cke R, with genetically modified herbicide- resistant maize. Haesaert G, Steurbaut W, Transgenic Research 17 (6):1059-1077. DOI: Reheul D 10.1007/s11248-008- 9181-8.

IIA 8.16 Diaz G, Carrillo C, 2003 Differential responses of ectomycorrhizal fungi to 1 Honrubia M pesticides in pure culture. Crypto- gamie Mycologie 24 (3):199-211 IIA 8.16 Dinehart SK, Smith LM, 2009 Toxicity of a glufosinate- and several glyphosate- 2 McMurry ST, Anderson based herbicides to juvenile amphibians from the TA, Smith PN, Haukos Southern High Plains, USA. Sci Total Environ 407 DA (3):1065-71. DOI: 10.1016/j.scitotenv.2008.10.010.

IIA 8.16 Dinehart SK, Smith LM, 2010 Acute and chronic toxicity of Roundup Weathermax 3 K McMurry ST, Smith PN, (R) and Ignite (R) 280 SL to larval Spea multiplicata Anderson TA, Haukos and S. bombifrons from the Southern High Plains, DA USA. Envi- ronmental Pollution 158 (8):2610-2617. DOI 10.1016/j.envpol.2010.05.006.

IIA 8.16 Ding W, Reddy KN, 2011 Physiological responses of glyphosate- resistant and 3 K Zablotowicz RM, glyphosate-sensitive soybean to Bellaloui N, Arnold aminomethylphosphonic acid, a metabolite Bruns H of glyphosate. Chemosphere 83 (4):593-8. DOI: 10.1016/j.chemosphere.2010.12.008.

IIA 8.16 Dixon FL, Clay DV, 2002 Susceptibility of woodland plants to herbicide drift. 1 Wiloughby I Quarterly Journal of Forestry 96 (1):32-36 IIA 8.16 Dominguez-Cortinas G, 2008 Analysis of the toxicity of glyphosate and Faena® 1 Saavedra JM, Santos- using the freshwater invertebrates Daphnia magna Medrano GE, Rico- and Lecane quadridentata. Toxicological & Martinez R Environmental Chemistry 90 (2):377 - 384

Page 156 of 192

- 157 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 dos Santos JB, Fer- reira 2005 Tolerance of Bradyrhizobium strains to glyphosate 2 EA, Kasuya MCM, da formulations. Crop Protection 24 (6):543-547. DOI Silva AA, Procopio SDO 10.1016/j.cropro.2004.10.007.

IIA 8.16 Drouin P, Sellami M, 2010 Tolerance to agricultural pesticides of strains 1 Prevost D, Fortin J, belonging to four genera of Rhizobiaceae. Journal of Antoun H Environmental Science and Health Part B-Pesticides Food Contaminants and Agricultural Wastes 45 (8):757-765. doi: 10.1080/03601234.2010.515168.

IIA 8.16 Druart C, Millet M, 2011 Glyphosate and glufosinate-based herbicides: fate 1 Also listed Scheifler R, Delhomme in soil, transfer to, and effects on land snails. under O, de Vaufleury A Journal of Soils and Sediments 11 (8):1373-1384. IIA 7.13 doi: 10.1007/s11368-011-0409-5.

IIA 8.16 Druart C, Millet M, 2011 Snails as indicators of pesticide drift, deposit, transfer 2 Scheifler R, Del- and effects in the vineyard. Science of the Total homme O, Raeppel C, Environment 409 (20):4280-4288. DOI de Vaufleury A 10.1016/j.scitotenv.2011.07.006.

IIA 8.16 Druart C, Scheifler 2010 Towards the development of an embryotoxicity 2 R, de Vaufleury A bioassay with terrestrial snails: Screening approach for cadmium and pesticides. Journal of Hazardous Materials 184 (1-3):26-33. DOI 10.1016/j.jhazmat.2010.07.099.

IIA 8.16 Druart C, Scheifler 2012 Landsnail eggs bioassays: A new tool to assess 1 R, Millet M, de Vau- embryotoxicity of contaminants in the solid, liquid or fleury A gaseous phase of soil. Ap- plied Soil Ecology 53:56- 64. doi: 10.1016/j.apsoil.2011.11.006.

IIA 8.16 Duke S, Wedge D, 2007 Interactions Of Synthetic Herbicides With Plant 1 Cerdeira A, Matallo M Disease And Microbial Herbicides. In Novel Biotechnologies for Biocontrol Agent Enhancement and Management. pp 277-296.

IIA 8.16 Duke SO, Powles SB 2008 Glyphosate: a once-in-a-century herbicide. Pest 1 Also listed Manag Sci 64 (4):319-25. DOI: under 10.1002/ps.1518. IIA 7.13

IIA 8.16 Dunfield KE, Germi- da 2004 Impact of genetically modified crops on soil- and 1 JJ plant-associated microbial communities. Journal of Environmental Quality 33 (3):806-815

IIA 8.16 Dutra BK, Fernandes FA, 2011 Effect of Roundup(R) (glyphosate formulation) in 3 K Failace DM, Oliveira GT the energy metabolism and reproductive traits of Hyalella castroi (Crustacea, Amphipoda, Dogielinotidae). Ecotoxicology 20 (1):255-63. DOI: 10.1007/s10646-010-0577-x. IIA 8.16 Eason TH, Scanlon 2002 Effects of Atrazine and Glyphosate ingestion on body 1 PF weight and nutritional well-being of Coturnix quail. Zeitschrift Fur Jagdwissen- schaft 48:281-285

Page 157 of 192

- 158 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Edge CB, Gahl MK, Pauli 2011 Exposure of juvenile green frogs (Lithobates 1 BD, Thompson DG, clamitans) in littoral enclosures to a glyphosate-based Houlahan JE herbicide. Ecotoxicology and Environmental Safety 74 (5):1363-1369. DOI 10.1016/j.ecoenv.2011.04.020. IIA 8.16 Edginton AN, Sheridan 2004 A comparison of two factorial designs, a complete 2 PM, Boermans HJ, 3X3 factorial and a central composite rotatable design, Thompson DG, Holt JD, for use in binomial response experiments in aquatic Stephenson GR toxicology. Archives of Environmental Con- tamination and Toxicology 46 (2):216-223. DOI 10.1007/s00244-003-2176-9. IIA 8.16 Edginton AN, 2004 Comparative effects of pH and Vision (R) herbicide 2 E K Sheridan PM, on two life stages of four anuran amphibian species. Stephenson GR, Environmental Toxico- logy and Chemistry 23 Thompson DG, (4):815-822 Boermans HJ

IIA 8.16 Elandalloussi LM, Leite 2008 Effect of the herbicide Roundup (R) on Perkinsus 1 RB, Rodrigues PM, olseni in vitro Proliferation and in vivo survival when Afonso R, Cancela ML infecting a permissive host, the clam Ruditapes decussatus. Bulletin of Environmental Contamination and Toxi- cology 80 (6):512-515. DOI 10.1007/s00128-008-9412-y.

IIA 8.16 Ellis JM, Griffin JL 2002 Soybean (Glycine max) and cotton (Gossypium 1 hirsutum) response to simulated drift of glyphosate and glufosinate. Weed Technology 16 (3):580-586

IIA 8.16 Ellis JM, Griffin JL, 2003 Rice (Oryza sativa) and corn (Zea mays) response to 1 Linscombe SD, Web- ster simulated drift of glyphosate and glufosinate. Weed ER Technology 17 (3):452- 460

IIA 8.16 El-Sayed EA 2003 Efficiency of biocontrol agents to control fusarial 2 diseases of watermelon as influenced by herbicide Roundup. Assiut Journal of Agricultural Sciences 34 (2):225- 239

IIA 8.16 El-Shenawy NS, 2003 Physiological and behavioural responses of Ruditapes 1 Abdel-Nabi IM, decussatus to roundup and reldan. Egyptian Journal of Moawad TI, A. TI Biology 5:108-119 IIA 8.16 Enrich-Prast A 2006 Effect of pesticides on nitrification in aquatic 2 sediment. Braz J Biol 66 (2A):405-12 IIA 8.16 Eriksson E, Baun A, 2007 Risk assessment of xenobiotics in stormwater 1 (8.16) Also listed Mikkelsen PS, Ledin A discharged to Harrestrup angstrom, Denmark. 2 (7.13) under Desalination 215 (1- IIA 7.13 3):187-197. DOI 10.1016/j.desal.2006.12.008.

IIA 8.16 Evans SC, Shaw EM, 2010 Exposure to a glyphosate-based herbicide affects 3 K Rypstra AL agrobiont predatory arthropod behaviour and long- term survival. Ecotoxi- cology 19 (7):1249-57. DOI: 10.1007/s10646-010-0509-9.

IIA 8.16 Evrard E, Marchand J, 2010 Impacts of mixtures of herbicides on molecular and 1 Theron M, Pichavant- physiological responses of the European flounder Rafini K, Durand G, Platichthys flesus. Comparative Biochemistry and Quiniou L, Laroche J Physiology Part C: Toxicology and Pharmacology 152 (3):321-331. DOI: 10.1016/j.cbpc.2010.05.009.

Page 158 of 192

- 159 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Favret KP, Lynn JW 2010 Flow-Cytometric Analyses of Viability Biomarkers in 2 Pesticide-Exposed Sperm of Three Aquatic Invertebrates. Archives of Environmental Contamination and Toxico- logy 58 (4):973-984. DOI: 10.1007/s00244- 009-9410-z.

IIA 8.16 Felix J, Boydston R, 2011 Potato Response to Simulated Glyphosate Drift. 2 Burke IC Weed Technology 25 (4):637-644. DOI: 10.1614/wt-d-11-00001.1. IIA 8.16 Feng PCC, Baley GJ, 2005 Glyphosate inhibits rust diseases in glyphosate- 1 Clinton WP, Bunkers GJ, resistant wheat and soybean. Proceedings of the Alibhai MF, Paulitz TC, National Academy of Sciences of the United Kidwell KK States of America 102 (48):17290-17295. DOI 10.1073/pnas.0508873102.

IIA 8.16 Feng PCC, Clark C, 2008 The control of Asian rust by glyphosate in 1 Andrade GC, Balbi MC, glyphosate-resistant soybeans. Pest Mana- gement Caldwell P Science 64 (4):353-359. Doi 10.1002/Ps.1498.

IIA 8.16 Fernandez MP, Zent- ner 2007 Impacts of crop production factors on common root 3 K KP, DePauw rot of barley in eastern Saskatchewan. Crop RM, Gehl D, Steven- son Science 47 (4):1585- FC 1595. DOI 10.2135/cropsci2006.09.0606.

IIA 8.16 Fernandez MR, Hu- ber 2008 Impact of agronomic practices on populations of 3 K D, Basnyat P, Zentner Fusarium and other fungi in cereal and noncereal RP crop residues on the Canadian Prairies. Soil & Tillage Research 100 (1-2):60-71. DOI 10.1016/j.still.2008.04.008.

IIA 8.16 Fernandez MR, Sel- les 2005 Crop production factors associated with fusarium 3 K F, Gehl D, De- pauw head blight in spring wheat in eastern RM, Zentner RP Saskatchewan. Crop Science 45 (5):1908-1916. DOI 10.2135/cropsci2004.0197.

IIA 8.16 Fernandez MR, Zentner 2009 Glyphosate associations with cereal diseases caused 3 K RP, Basnyat P, Gehl D, by Fusarium spp. in the Canadian Prairies. European Selles F, Huber D Journal of Agronomy 31 (3):133-143

IIA 8.16 Fernandez MR, Zentner 2007 Impacts of crop production factors on fusarium 3 K RP, DePauw RM, Gehl D, head blight in barley in eastern Saskatchewan. Steven- son FC Crop Science 47 (4):1574- 1584. DOI 10.2135/cropsci2006.09.0596.

IIA 8.16 Ferreira D, Motta 2010 Assessment of oxidative stress in Rhamdia quelen 1 ACd, Kreutz LC, Toni exposed to agrichemicals. Che- mosphere 79 C, Loro VL, Barcellos (9):914-921. DOI: LJG 10.1016/j.chemosphere.2010.03.024.

IIA 8.16 Filizadeh Y, Islami 2011 Toxicity determination of three sturgeon species 3 K HR exposed to glyphosate. Iranian Jour- nal of Fisheries Sciences 10 (3):383-392 IIA 8.16 Franca AC, Freitas 2010 Nutrient Content in Arabica Coffee Cultivars 2 MAM, D'Antonino Subjected to Glyphosate Drift. Planta Da- ninha 28 L, Fialho CMT, Silva (4):877-885. doi: 10.1590/s0100- AA, Reis MR, 83582010000400021. Ronchi CP

Page 159 of 192

- 160 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Frontera JL, Vatnick I, 2011 Effects of Glyphosate and Polyoxyethylenamine on 2 Chaulet A, Rodriguez Growth and Energetic Reserves in the Freshwater EM Crayfish Cherax quadricarinatus (Decapoda, Parastacidae). Archives of Environmental Contamination and Toxicology 61 (4):590- 598. DOI 10.1007/s00244-011-9661-3.

IIA 8.16 Fuentes L, Moore LJ, 2011 Comparative toxicity of two glyphosate formulations 1 Rodgers Jr. JH, Bowerman (original formulation of Roundup and Roundup WW, Yarrow GK, Chao WeatherMAX) to six North American larval anurans. WY Environ- mental toxicology and chemistry / SETAC 30 (12):2756-61. doi: 10.1002/etc.670. IIA 8.16 Gahl MK, Pauli BD, 2011 Effects of chytrid fungus and a glyphosate- based 2 Houlahan JE herbicide on survival and growth of wood frogs (Lithobates sylvaticus). Ecologi- cal Applications 21 (7):2521-2529

IIA 8.16 García-del-Pino F, 2010 Synergistic effect of the herbicides glyphosate and 2 Morton A MCPA on survival of entomopathogenic nematodes. Biocontrol Science and Technology 20 (5):483-488. DOI: 10.1080/09583151003592844.

IIA 8.16 Garcia-Orenes F, Guerrero 2010 Soil microbial biomass and activity under different 2 C, Roldan A, Mataix- agricultural management systems in a semiarid Solera J, Cerda A, Mediterranean agroecosystem. Soil & Tillage Campoy M, Zornoza R, Research 109 (2):110-115. doi: Barcenas G, Caravaca F 10.1016/j.still.2010.05.005.

IIA 8.16 Garnett R 2001 The herbicide Glyphosate: A Scientific 1 Overview. In Genetic Engineering and Ecology. pp 58-63. IIA 8.16 Ge H, Liu S, Zhu X, 2008 Microplate algae toxicity of 9 pesticides to 2 Wang L Scenedesmus obliquus based on absorbance. Asian Journal of Ecotoxicology 3 (6):606- 612

IIA 8.16 Gilreath JP, Chase 2001 Crop injury from sublethal rates of herbicide. 1 CA I. Tomato. Hortscience 36 (4):669-673

IIA 8.16 Giolo FP, Grützma- cher 2005 Side-effects of glyphosate formulations on 2 AD, Procópio SO, Trichogramma pretiosum (Hymenoptera: Manzoni CG, Lima Trichogrammatidae). Planta Daninha CAB, Nörn- berg SD 23:458-462

IIA 8.16 Glazko VI, Glazko TT, 2006 Change in the enzyme spectra of soil 1 Iutinskaya GA, microorganisms Micrococcus luteus CCM Yamborko NI 248 and Stenotrophomonas maltophilia UKM V- 257 under the effect of certain pesticides. Russian Agricultural Sciences 5:8-1

IIA 8.16 Glusczak L, Loro V, 2011 Acute Exposure to Glyphosate Herbicide Affects 2 Pretto A, Moraes B, Oxidative Parameters in Piava (Leporinus Raabe A, Duarte M, da obtusidens). Archives of Environmental Fonseca M, de Menezes Contamination and Toxicology 61 (4):624-630. C, de Sousa Valladão D DOI: 10.1007/s00244-011-9652-4.

Page 160 of 192

- 161 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Glusczak L, Miron DD, 2007 Acute effects of glyphosate herbicide on metabolic 2 Moraes BS, Simoes RR, and enzymatic parameters of silver catfish (Rhamdia Schetin- ger MRC, quelen). Comparative Biochemistry and Physiology Morsch VM, Loro VL C-Toxicology & Pharmacology 146 (4):519- 524. DOI 10.1016/j.cbpc.2007.06.004.

IIA 8.16 Glusczak L, Miron DDS, 2006 Effect of glyphosate herbicide on 1 Crestani M, da Fonseca acetylcholinesterase activity and metabolic and MB, Pedron FDA, Duarte hematological parameters in piava (Leporinus MF, Vieira VUP obtusidens). Ecotoxicology and Environmental Safety 65 (2):237-241. DOI 10.1016/j.ecoenv.2005.07.017.

IIA 8.16 Gomez E, Ferreras L, 2009 Impact of glyphosate application on microbial 1 Lovotti L, Fernandez E biomass and metabolic activity in a Vertic Argiudoll from Argentina. Europe- an Journal of Soil Biology 45 (2):163-167. DOI 10.1016/j.ejsobi.2008.10.001.

IIA 8.16 Gopal K, Babu GP 2004 Efficacy of pesticides on population dynamics of 1 Fusarium solani, a causal agent of dry root-rot of citrus. Geobios (Jodhpur) 31 (1):67-68

IIA 8.16 Goradia L, Hartman 2009 Evaluation of glyphosate-tolerant soybean cultivars for 1 G, Daniel S resistance to bacterial pustule. European Journal of Plant Pathology 124 (2):331-335. doi: 10.1007/s10658-008-9410- 2.

IIA 8.16 Gove B, Power SA, 2007 Effects of herbicide spray drift and fertilizer 2 Buckley GP, Ghazoul J overspread on selected species of woodland ground flora: comparison between short- term and long-term impact assessments and field surveys. Journal of Applied Ecology 44 (2):374-384. DOI 10.1111/j.1365- 2664.2007.01261.x.

IIA 8.16 Gravena R, Filho RV, 2009 Low glyphosate rates do not affect Citrus 1 Alves PLC, limonia (L.) Osbeck seedlings. Pest Management Mazzafera P, Science 65 (4):420-425 Gravena AR

IIA 8.16 Gregorc A, Ellis JD 2011 Cell death localization in situ in laboratory reared 3 K honey bee (Apis mellifera L.) larvae treated with pesticides. Pesticide Bioche- mistry and Physiology 99 (2):200-207. DOI: 10.1016/j.pestbp.2010.12.005.

IIA 8.16 Gregorc A, Evans JD, 2012 Gene expression in honey bee (Apis mellifera) larvae 3 K Scharf M, Ellis JD exposed to pesticides and Varroa mites (Varroa destructor). Journal of Insect Physiology (0). DOI: 10.1016/j.jinsphys.2012.03.015.

IIA 8.16 Gressel J 2010 Herbicides as Synergists for Mycoherbicides, and 1 Vice Versa. Weed Science 58 (3):324-328. DOI: 10.1614/ws- 09-071.1.

Page 161 of 192

- 162 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Griesinger LM, Evans 2011 Effects of a glyphosate-based herbicide on mate 3 K SC, Rypstra AL location in a wolf spider that inhabits agroecosystems. Chemosphere 84 (10):1461-1466. DOI: 10.1016/j.chemosphere.2011.04.044.

IIA 8.16 Grisolia CK 2002 A comparison between mouse and fish micronucleus 1 Also listed test using cyclophosphamide, mitomycin C and under various pesticides. Mutati- on Research-Genetic IIA 5.10 Toxicology and Envi- ronmental Mutagenesis 518 (2):145-150

IIA 8.16 Guilherme S, Gaivão I, 2010 European eel (Anguilla anguilla) genotoxic and pro- 3 (8.16) K Also listed Santos MA, Pacheco M oxidant responses following short- term exposure to 2 (5.10) under Roundup®—a glyphosate- based herbicide. E IIA 5.10 Mutagenesis 25 (5):523- 530. DOI: 10.1093/mutage/geq038.

IIA 8.16 Hall LW, Killen WD, 2007 Relationship of Farm Level Pesticide Use and Physical 1 Alden RW Habitat on Benthic Community Status in a California Agricultural Stream. Human and Ecological Risk Assessment: An International Journal 13 (4):843-869. DOI: 10.1080/10807030701456775.

IIA 8.16 Haller WT, Stocker 2003 Toxicity of 19 adjuvants to juvenile Lepomis 2 RK macrochirus (bluegill sunfish). Environmen- tal Toxicology and Chemistry 22 (3):615- 619

IIA 8.16 Haney RL, Senseman 2002 Effect of roundup ultra on microbial activity and 1 Also listed SA, Hons FM biomass from selected soils. Journal of Environmental under Quality 31 (3):730-735 IIA 7.13

IIA 8.16 Haney RL, Senseman SA, 2002 Soil carbon and nitrogen mineralization as affected by 1 Also listed Krutz LJ, Hons FM atrazine and glyphosate. Biology and Fertility of Soils under 35 (1):35-40. DOI IIA 7.13 10.1007/s00374-001-0437-1.

IIA 8.16 Harikrishnan R, 2002 Effects of herbicides on root rot and 1 Yang XB damping-off caused by Rhizoctonia solani in glyphosate-tolerant soybean. Plant Disease 86 (12):1369-1373

IIA 8.16 Harikrishnan R, 2001 Influence of herbicides on growth and sclerotia 1 Yang XB production in Rhizoctonia solani. Weed Science 49 (2):241-247 IIA 8.16 Hart MM, Powell JR, 2009 Separating the effect of crop from herbicide on soil 1 Gulden RH, Dunfield KE, microbial communities in glyphosate- resistant corn. Peter Pauls K, Swanton Pedobiologia 52 (4):253-262 CJ, Kliro- nomos JN, Antunes PM, Koch AM, Tre- vors JT

IIA 8.16 Hedberg D, Wallin 2010 Effects of Roundup and glyphosate formulations on 2 M intracellular transport, microtubules and actin filaments in Xenopus laevis melanophores. Toxicol In Vitro 24 (3):795-802. DOI: 10.1016/j.tiv.2009.12.020.

Page 162 of 192

- 163 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Helbing CC, Maher SK, 2010 Peering into molecular mechanisms of action with 1 Han J, Gunderson MP, frogSCOPE. General and Comparative Endocrinology Borchers C 168 (2):190-198. DOI: 10.1016/j.ygcen.2010.01.012.

IIA 8.16 Henriksen B, Elen O 2005 Natural Fusarium grain infection level in wheat, 1 barley and oat after early application of fungicides and herbicides. Journal of Phytopathology 153 (4):214-220

IIA 8.16 Howe CM, Berrill M, 2004 Toxicity of glyphosate-based pesticides to four North 3 K Pauli BD, Helbing CC, American frog species. Environ- mental Toxicology Werry K, Veld- hoen N and Chemistry 23 (8):1928-1938

IIA 8.16 Hu B-Y, Hsieh H-J, Yao 2005 Study on the Tolerance of Some Soil Fungi to 1 J-C, Fu C-H Glyphosate. J Exp For Nat Taiwan Univ 19 (1):17-23 IIA 8.16 Huang XJ, Fong S, 2005 Toxicity of herbicides in highway runoff. 1 Deanovic L, Young TA Environmental Toxicology and Chemistry 24 (9):2336-2340 IIA 8.16 Hued A, Oberhofer S, 2012 Exposure to a Commercial Glyphosate Formulation 3 K de los Ángeles Bistoni (Roundup) Alters Normal Gill and Liver Histology M and Affects Male Sexual Activity of Jenynsia multidentata (Anablepidae, Cyprinodontiformes). Archi- ves of Environmental Contamination and Toxicology 62 (1):107-117. DOI: 10.1007/s00244-011-9686-7.

IIA 8.16 Imfeld G, Vuilleu- 2012 Measuring the effects of pesticides on bacterial 1 mier S communities in soil: A critical review. European Journal of Soil Biology. doi: 10.1016/j.ejsobi.2011.11.010.

IIA 8.16 Imura O, Shi K, Iimura 2010 Assessing the effects of cultivating genetically 2 K, Takamizo T modified glyphosate-tolerant varieties of soybeans (Glycine max (L.) Merr.) on populations of field arthropods. Environ Biosafety Res 9 (2):101-12. DOI: 10.1051/ebr/2010010.

IIA 8.16 Inderjit I, Kaushik S 2010 Effect of herbicides with different modes of action on 2 physiological and cellular traits of Anabaena fertilissima. Paddy and Water Environment 8 (3):277- 282. DOI: 10.1007/s10333-010-0208-4.

IIA 8.16 Irvine IC, Witter MS, 2012 Relationships between Methylobacteria and 2 Brigham CA, Glyphosate with Native and Invasive Plant Species: Martiny JBH Implications for Restoration. Resto- ration Ecology. doi: 10.1111/j.1526- 100X.2011.00850.x.

IIA 8.16 Jayawardena UA, 2011 Acute and chronic toxicity of four commonly used 3 K Navaratne AN, agricultural pesticides on Amerasinghe PH, the Asian common toad, Bufo melanostictus Rajakaruna RS Schneider. Journal of the National Science Foundation of Sri Lanka 39 (3):267-276. doi: 10.4038/jnsfsr.v39i3.3631.

Page 163 of 192

- 164 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Jayawardena UA, 2010 Toxicity of Agrochemicals to Common Hourglass 3 K Rajakaruna RS, Tree Frog (Polypedates cruciger) in Acute and Navaratne AN, Chronic Exposure. Internatio- nal Journal of Amerasinghe PH Agriculture and Biology 12 (5):641-648

IIA 8.16 Jiang W, Garrett KA, 2005 The window of risk for emigration of Wheat streak 1 Peterson DE, Harvey TL, mosaic virus varies with host eradication method. Bowden RL, Fang L Plant Disease 89 (8):853-858. Doi 10.1094/Pd-89-0853.

IIA 8.16 Jiraungkoorskul W, 2003 Biochemical and histopathological effects of 1 E K Upatham ES, glyphosate herbicide on Nile tilapia (Oreochromis Kruatrachue M, niloticus). Environmental Toxicology 18 (4):260-267. Sahaphong S, Vichasri- Doi Grams S, Pokethitiyook 10.1002/Tox.10123. P

IIA 8.16 Jiraungkoorskula W, 2002 Histopathological Effects of Roundup, a Glyphosate 1 Upatham ES, Herbicide, on Nile tilapia ( Oreochromis niloticus). Kruatrachue M, ScienceAsia 28:121- Sahaphong S, Vichasri- 127 DOI: 10.2306/scienceasia1513- Grams S, Pokethitiyook P 1874.2002.28.121. IIA 8.16 Johal GS, Huber DM 2009 Glyphosate effects on diseases of plants. European 2 K Journal of Agronomy 31 (3):144- 152 IIA 8.16 Jones DK, Hammond 2011 Competitive stress can make the herbicide Roundup® 3 K JI, Relyea RA more deadly to larval amphibians. Environmental Toxicology and Chemistry 30 (2):446-454. DOI: 10.1002/etc.384.

IIA 8.16 Jones DK, Hammond 2010 Roundup® and amphibians: The importance of 3 K JI, Relyea RA concentration, application time, and stratification. Environmental Toxicology and Chemistry 29 (9):2016-2025. DOI: 10.1002/etc.240.

IIA 8.16 Kaiser K 2011 Preliminary Study of Pesticide Drift into the Maya 1 Also listed Mountain Protected Areas of Belize. Bulletin of under Environmental Contamination and Toxicology 86 IIA 7.13 (1):56-59. doi: 10.1007/s00128-010-0167-x.

IIA 8.16 Kaneda S, Okano S, 2009 Effects of herbicides, glyphosate, on density and 1 T Urashima Y, Mura- kami casting activity of earthworm, Pheretima (Amynthas) T, Nakajima M carnosus. Japanese Journal of Soil Science and Plant Nutrition 80:469-476

IIA 8.16 Kannan C, Kathire- san 2002 Herbicidal control of water hyacinth and its impact 1 RM on fish growth and water quality. Indian J. Weed Sci. 34 (1-2):92-95 IIA 8.16 Kaschuk G, Alberton 2009 Three decades of soil microbial biomass studies in 1 O, Hungria M Brazilian ecosystems: Lessons learned about soil quality and indications for improving sustainability. Soil Biology and Biochemistry In Press, Corrected Proof. DOI: 10.1016/j.soilbio.2009.08.020.

Page 164 of 192

- 165 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Kelly DW, Poulin R, 2010 Synergistic effects of glyphosate formulation and 3 K Tompkins DM, Townsend parasite infection on fish malformations and survival. CR Journal of Applied Ecology 47 (2):498-504. DOI: 10.1111/j.1365- 2664.2010.01791.x.

IIA 8.16 Kerby JL, Richards- 2010 An examination of amphibian sensitivity to 1 Hrdlicka KL, Storfer A, environmental contaminants: are amphibians poor Skelly DK canaries? Ecology Letters 13 (1):60-67. DOI 10.1111/j.1461-0248.2009.01399.x.

IIA 8.16 Keum YS, Lee HR, Kim 2010 Effects of Pesticides on the Bacterial Production of 1 JH Pyrrolnitrin. Journal of Agri- cultural and Food Chemistry 58 (9):5531- 5537. Doi 10.1021/Jf904195j.

IIA 8.16 Khokhar UU, 2001 Changes in some physicochemical and microbiological 1 Sharma MK, Singh R properties of the soil under various systems of floor management in almond (Prunus amygdalus Batsch.) orchard. Journal of the Indian Society of Soil Science 49 (1):213-215

IIA 8.16 Kielak E, Sempruch C, 2011 Phytotoxicity of Roundup Ultra 360 SL in aquatic 2 Mioduszewska H, Klocek ecosystems: Biochemical evaluation with duckweed J, Leszc- zyński B (Lemna minor L.) as a model plant. Pesticide Biochemistry and Physiolo- gy 99 (3):237-243. DOI: 10.1016/j.pestbp.2011.01.002.

IIA 8.16 King CA, Purcell 2001 Plant growth and nitrogenase activity of glyphosate- 1 LC, Vories ED tolerant soybean in response to foliar glyphosate applications. Agronomy Journal 93 (1):179-186

IIA 8.16 King JJ, Wagner RS 2010 Toxic Effects of the Herbicide Roundup® Regular 3 K on Pacific Northwestern Amphibians. Northwestern Naturalist 91 (3):318-324. DOI: 10.1898/nwn09- 25.1.

IIA 8.16 Kleter GA, Harris C, 2008 Comparison of herbicide regimes and the associated 1 Also listed Stephenson G, Uns- potential environmental effects of glyphosate-resistant under worth J crops versus what they replace in Europe. Pest Manag IIA 7.13 Sci 64 (4):479-88. DOI: 10.1002/ps.1513.

IIA 8.16 Koger CH, Shaner DL, 2005 Rice (Oryza satiova) response to drift rates of 1 Krutz LJ, Walker TW, glyphosate. Pest Management Science 61 (12):1161- Buehring N, Henry 1167. Doi 10.1002/Pt.1113. WB, Thomas WE, Wilcut JW

IIA 8.16 Kortekamp A 2011 Unexpected Side Effects of Herbicides: Modulation 1 of Plant-Pathogen Interactions. In Herbicides and Environment, edited by A. Kortekamp. Croatia. InTech. pp 85 - 104.

IIA 8.16 Kramer V, Blewett 2008 Comments on "Evaluation of Estrogenic Activities 2 (8.16) Also listed C, Gersich M of Aquatic Herbicides and Surfactants Using a 1 (5.10) under Rainbow Trout Vitellogenin Assay". Toxicol. Sci. IIA 5.10 104 (1):228-230. DOI: 10.1093/toxsci/kfn067.

IIA 8.16 Kremer RJ 2006 Deleterious Rhizobacteria. In Plant- 2 Associated Bacteria, edited by S. S. Gnanamanickam. pp 335-357.

Page 165 of 192

- 166 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Kremer RJ, Kussman 2011 Soil quality in a pecan-kura clover alley cropping 1 RD system in the Midwestern USA. Agroforestry Systems 83 (2):213-223. doi: 10.1007/s10457-011-9370-y.

IIA 8.16 Kremer RJ, Means 2009 Glyphosate and glyphosate-resistant crop interactions 2 K NE with rhizosphere microorganisms. European Journal of Agro- nomy 31 (3):153-161

IIA 8.16 Kreutz LC, Barcellos LJ, 2010 Exposure to sublethal concentration of glyphosate or 3 K Marteninghe A, Dos atrazine-based herbicides alters the phagocytic Santos ED, Zanatta R function and increases the susceptibility of silver catfish fingerlings (Rhamdia quelen) to Aeromonas hydrophila challenge. Fish Shellfish Immunol 29 (4):694-7. DOI: 10.1016/j.fsi.2010.06.003.

IIA 8.16 Kreutz LC, Barcellos LJG, 2008 Acute toxicity test of agricultural pesticides on silver 1 Silva TO, Anzilierol D, catfish (Rhamdia quelen) fingerlings. Ciencia Rural Martins D, Lorenson M, 38 (4):1050-1055 Marteninghe A, da Silva LB

IIA 8.16 Kreutz LC, Gil Bar- 2011 Altered hematological and immunological 3 K cellos LJ, de Faria Valle parameters in silver catfish (Rhamdia quelen) S, de Oliveira Silva T, following short term exposure to sublethal Anziliero D, Davi dos concentration of glyphosate. Fish Shellfish Immunol Santos E, Pivato M, 30 (1):51-7. DOI: Zanatta R 10.1016/j.fsi.2010.09.012.

IIA 8.16 Krzysko-Lupicka T 2008 Ecological effects of phosphoorganic herbicide on soil 1 diazotrophs in spring. Part II. Ecological Chemistry & Engineering S 15 (4):595-602

IIA 8.16 Krzysko-Lupicka T, 2008 Ecological effects of phosphoorganic herbicide on soil 1 Grata K diazotrophs in autumn. Part I. Ecological Chemistry and Engineering S- Chemia I Inzynieria Ekologiczna S 15 (1):95-102

IIA 8.16 Krzysko-Lupicka T, 2005 The Ability Of Selected Fusarium Fungi To A 1 Sudol T Growth In the Presence Of Different Glyphosate Concentrations. Polish Journal of Chemical Technology 7 (2):10-15

IIA 8.16 Krzysko-Lupicka T, 2008 Interactions between glyphosate and autochthonous 1 Sudol T soil fungi surviving in aqueous solution of glyphosate. Chemosphe- re 71 (7):1386-91. DOI: 10.1016/j.chemosphere.2007.11.006.

IIA 8.16 Kuklinsky-Sobral HL, 2005 Isolation and characterization of endophytic bacteria 2 Araujo WL, Mendes R, from soybean (Glycine max) grown in soil treated Pizzirani- Kleiner AA, with glyphosate herbicide. Plant and Soil 273 (1- Azeve- do JL 2):91-99. DOI 10.1007/s11104-004-6894-1.

IIA 8.16 Kulesza AE, Holo- muzki 2008 Benthic community structure in stands of Typha 1 JR, Klarer DM angustifolia and herbicide-treated and untreated Phragmites australis. Wetlands 28 (1):40-56

Page 166 of 192

- 167 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Kumar K, Han T 2010 Physiological response 2 ofLemna species to herbicides and its probable use in toxicity testing. Toxicology and Environmental Health Sciences 2 (1):39-49. DOI: 10.1007/bf03216512.

IIA 8.16 Kumar PKR, Rao 2007 Influence of pesticides on growth and sporulation of 1 AN Ascochyta cypericola. Ann Pl Protect Sci 15 (2):530- 531 IIA 8.16 Kurtz ME, Street JE 2003 Response of rice (Oryza sativa) to glyphosate 1 applied to simulate drift. Weed Technology 17 (2):234-238 IIA 8.16 Kyaw KM, Toyota K 2007 Suppression of nitrous oxide production by the 1 herbicides glyphosate and propanil in soils supplied with organic matter. Soil Science and Plant Nutrition 53 (4):441-447. DOI 10.1111/j.1747- 0765.2007.00151.x.

IIA 8.16 Laatikainen T, Hei- 2002 Mycorrhizal growth in pure cultures in the presence 1 nonen-Tanski H of pesticides. Microbiological Re- search 157 (2):127-137 IIA 8.16 Lajmanovich R, 2003 Comparative acute toxicity of the commercial 2 Lorenzatti E, Maitre MI, herbicides glyphosate to neotropical tadpoles Scinax Enrique S, Pelt- zer P nasicus (Anura : Hylidae). Fresenius Environmental Bulletin 12 (4):364-367

IIA 8.16 Lajmanovich RC, 2011 Toxicity of Four Herbicide Formulations with 3 K Attademo AM, Pelt- zer Glyphosate on Rhinella arenarum (Anura: Bufonidae) PM, Junges CM, Tadpoles: B-esterases and Glutathione S-transferase Cabagna MC Inhibitors. Arch Environ Contam Toxicol 60 (4):681- 9. DOI: 10.1007/s00244-010-9578-2. IIA 8.16 Lajmanovich RC, Peltzer 2010 Activity levels of B-esterases in the tadpoles of 11 3 K PM, Junges CM, species of frogs in the middle Paraná River Attademo AM, Sanchez floodplain: Implication for ecological risk assessment LC, Bassó A of soybean crops. Ecotoxi- cology and Environmental Safety 73 (7):1517-1524. DOI: 10.1016/j.ecoenv.2010.07.047.

IIA 8.16 Lajmanovich RC, 2003 Induction of mortality and malformation in Scinax 2 E K Sandoval MT, Pelt- zer nasicus tadpoles exposed to glyphosate formulations. PM Bulletin of Envi- ronmental Contamination and Toxicology 70 (3):612-618. DOI 10.1007/s00128- 003- 0029-x.

IIA 8.16 Lancaster SH, Haney RL, 2006 Soil microbial activity is affected by Roundup 2 Senseman SA, Hons FM, WeatherMax and pesticides applied to cotton Chandler JM (Gossypium hirsutum). J Agric Food Chem 54 (19):7221-6. DOI: 10.1021/jf061673p.

IIA 8.16 Lancaster SH, Hol- lister 2010 Effects of repeated glyphosate applications on soil 2 Also listed EB, Senseman SA, microbial community composition and the under Gentry TJ mineralization of glyphosate. Pest Manag Sci 66 IIA 7.13 (1):59-64. DOI: 10.1002/ps.1831.

Page 167 of 192

- 168 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Lane M, Lorenz N, 2012 Microbial activity, community structure and 1 Also listed Saxena J, Ramsier C, potassium dynamics in rhizosphere soil of soybean under Dick RP plants treated with glyphosate. Pedobiologia 55 IIA 7.13 (3):153-159. doi: 10.1016/j.pedobi.2011.12.005.

IIA 8.16 Langiano VdC, Mar- 2008 Toxicity and effects of a glyphosate-based herbicide 2 tinez CBR on the Neotropical fish Prochilodus lineatus. Comparative Bioche- mistry and Physiology Part C: Toxicology & Pharmacology 147 (2):222-231

IIA 8.16 Larson RL, Hill AL, 2006 Influence of glyphosate on Rhizoctonia and Fusarium 2 Fenwick A, Kniss AR, root rot in sugar beet. Pest Mana- gement Science 62 Hanson LE, Miller SD (12):1182-1192. Doi 10.1002/Ps.1297.

IIA 8.16 Le TH, Lim ES, Lee SK, 2010 Effects of glyphosate and methidathion on the 3 K Choi YW, Kim YH, Min expression of the Dhb, Vtg, Arnt, CYP4 and CYP314 J in Daphnia magna. Che- mosphere 79 (1):67-71. DOI: 10.1016/j.chemosphere.2009.12.067.

IIA 8.16 Lee CD, Penner D, 2003 Glyphosate and shade effects on glyphosate- resistant 1 Hammerschmidt R soybean defense response to Sclerotinia sclerotiorum. Weed Science 51 (3):294-298

IIA 8.16 Lenkowski JR, San- 2010 Low concentrations of atrazine, glyphosate, 2 chez-Bravo G, Mc- 2,4-dichlorophenoxyacetic acid, and triadimefon Laughlin KA exposures have diverse effects on Xenopus laevis organ morphogenesis. J Environ Sci (China) 22 (9):1305-8

IIA 8.16 Li J, Wang H, Han Z, Shi 2010 Acute toxicity of eight pesticides on the 2 S, Wang Y, Ding J development of sea urchin embryos. Asian Journal of Ecotoxicology (Shengtai Duli Xuebao) 5 (2):255- 261

IIA 8.16 Li SN, Kole RK 2004 Response of gill ATPase and liver esterase of 2 pseudorasobora parva to a two month exposure to glyphosate and metsulfuron methyl. Toxicological & Environmental Chemistry 86 (4):239 - 245

IIA 8.16 Lindsay EA, French 2004 The impact of the herbicide glyphosate on leaf litter 1 K invertebrates within Bitou bush, Chrysanthemoides monilifera ssp rotundata, infestations. Pest Management Science 60 (12):1205-1212. Doi 10.1002/Ps.944.

IIA 8.16 Lins VS, Santos H, 2007 The effect of the glyphosate, 2,4-D, atrazine e 1 Goncalves MC nicosulfuron herbicides upon the edaphic collembola (Arthropoda : Ellipura) in a no tillage system. Neotropical Entomology 36 (2):261-267

IIA 8.16 Liphadzi KB, Al- Khatib 2005 Soil microbial and nematode communities as affected 1 K, Bensch CN, Stahlman by glyphosate and tillage practices PW, Dille JA, Todd T, in a glyphosate-resistant cropping system. Weed Rice CW, Horak MJ, Science 53 (4):536-545 Head G

Page 168 of 192

- 169 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Lipok J 2009 Dual action of phosphonate herbicides in plants 1 affected by herbivore-Model study on black bean aphid Aphis fabae rearing on broad bean Vicia faba plants. Ecotoxicology and Environmental Safety 72 (6):1701-1706. DOI 10.1016/j.ecoenv.2009.03.007.

IIA 8.16 Lipok J, Studnik H, 2010 The toxicity of Roundup® 360 SL formulation and 3 K Gruyaert S its main constituents: Glyphosate and isopropylamine towards non-target water photoautotrophs. Ecotoxi- cology and Environmental Safety 73 (7):1681-1688. DOI: 10.1016/j.ecoenv.2010.08.017.

IIA 8.16 Lo C-C 2010 Effect of pesticides on soil microbial community. 1 Journal of Environmental Science and Health, Part B 45 (5):348-359. DOI: 10.1080/03601231003799804.

IIA 8.16 Locke MA, Zabloto- wicz 2008 Integrating soil conservation practices and 1 RM, Reddy KN glyphosate-resistant crops: impacts on soil. Pest Manag Sci 64 (4):457-69. DOI: 10.1002/ps.1549.

IIA 8.16 Lu L-l, Zhang G-l, Li 2010 Effects of Glyphosate on the Growth and 1 Y-d, Gao X-w, Fu Development of Agasicles hygrophila. Jour- nal of W-d South China Agricultural University 31 (1):22-25

IIA 8.16 Lupwayi NZ, Harker KN, 2009 Soil microbial response to herbicides applied to 1 Clayton GW, O'Donovan glyphosate-resistant canola. Agriculture Ecosystems & JT, Blackshaw RE Environment 129 (1-3):171- 176. DOI 10.1016/j.agee.2008.08.007.

IIA 8.16 Lupwayi NZ, Harker KN, 2004 Soil microbial biomass and diversity after herbicide 1 Clayton GW, Turkington application. Canadian Journal of Plant Science 84 TK, Rice WA, (2):677-685 O'Donovan JT

IIA 8.16 Lushchak OV, Ku- brak 2009 Low toxic herbicide Roundup induces mild oxidative 1 OI, Storey JM, Storey KB, stress in goldfish tissues. Che- mosphere 76 (7):932- Lushchak VI 7. DOI: 10.1016/j.chemosphere.2009.04.045.

IIA 8.16 Lynch JD, Arroyo 2009 Risks to Colombian amphibian fauna from 2 SB cultivation of coca (Erythroxylum coca): a geographical analysis. J Toxicol Environ Health A 72 (15):974-85. DOI: 10.1080/15287390902929733.

IIA 8.16 Ma J 2002 Differential sensitivity to 30 herbicides among 1 populations of two green algae Scenedesmus obliquus and Chlorella pyrenoidosa. Bulletin of Environmental Contamination and Toxicology 68 (2):275- 281

IIA 8.16 Ma J, Liang W 2001 Acute toxicity of 12 herbicides to the green algae 1 Chlorella pyrenoidosa and Scenedesmus obliquus. Bull Environ Con- tam Toxicol 67 (3):347-51

IIA 8.16 Ma J, Liang W, Xu L, 2001 Acute toxicity of 33 herbicides to the green alga 1 Wang S, Wei Y, Lu J Chlorella pyrenoidosa. Bull Environ Contam Toxicol 66 (4):536-41

Page 169 of 192

- 170 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Ma J, Lin F, Wang S, Xu 2003 Toxicity of 21 herbicides to the green alga 1 L Scenedesmus quadricauda. Bulletin of Envi- ronmental Contamination and Toxicology 71 (3):594-601. DOI 10.1007/s00128-003- 8521-x.

IIA 8.16 Ma JY, Wang SF, 2006 Toxicity assessment of 40 herbicides to the green 1 Wang PW, Ma LJ, alga Raphidocelis subcapitata. Ecoto- xicology and Chen XL, Xu RF Environmental Safety 63 (3):456-462. DOI 10.1016/j.ecoenv.2004.12.001.

IIA 8.16 Ma JY, Xu LG, 2002 A quick, simple, and accurate method of 1 Wang SF screening herbicide activity using green algae cell suspension cultures. Weed Science 50 (5):555-559

IIA 8.16 Ma JY, Xu LG, 2002 Toxicity of 40 herbicides to the green alga Chlorella 1 Wang SF, Zheng RQ, Jin vulgaris. Ecotoxicology and Environmental Safety SH, Huang SQ, Huang YJ 51 (2):128-132. DOI 10.1006/eesa.2001.2113.

IIA 8.16 Magbanua FS, 2010 Responses of stream macroinvertebrates and 1 Townsend CR, ecosystem function to conventional, integrated and Blackwell GL, Phillips organic farming. Journal of Applied Ecology 47 N, Matthaei CD (5):1014-1025. DOI: 10.1111/j.1365-2664.2010.01859.x.

IIA 8.16 Mailloux J, Le Bellec 2010 Influence of ground cover management on diversity 1 F, Kreiter S, Tixier and density of phytoseiid mites (Acari: Phytoseiidae) M-S, Dubois P in Guadeloupean citrus orchards. Experimental and Applied Acaro- logy 52 (3):275-290. DOI: 10.1007/s10493- 010-9367-7.

IIA 8.16 Major WW, Grue CE, 2003 Concentrations of glyphosate and AMPA in sediment 1 Also listed Gardner SC, Grassley following operational applications of Rodeo (R) to under JM control smooth cordgrass in Willapa Bay, IIA 7.13 Washington, USA. Bulletin of Environmental Contamination and Toxico- logy 71 (5):912-918. DOI 10.1007/s00128- 003-8905-y.

IIA 8.16 Malkomes HP 2007 Influence of differently formulated glyphosate 1 herbicides and a herbicidal reference compound on microbial activities in soil. Nachrichtenbl. Deut. Pflanzen- schutzd. 59 (6):124-132 IIA 8.16 Malty JD, Siqueira 2006 Effects of glyphosate on soybean symbiotic 1 JO, Moreira FMD microorganisms, in culture media and in greenhouse. Pesquisa Agropecuaria Brasilei- ra 41 (2):285-291

IIA 8.16 Mann RM, Bidwell 2001 The acute toxicity of agricultural surfactants to the 1 JR tadpoles of four Australian and two exotic frogs. Environ Pollut 114 (2):195-205 IIA 8.16 Mann RM, Bidwell 2003 Toxicity of herbicide formulations to frogs and the 1 JR, Tyler MJ implications for product registration: A case study from Western Australia. Ap- plied Herpetology 1:13- 22

Page 170 of 192

- 171 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Mann RM, Hyne RV, 2009 Amphibians and agricultural chemicals: Review of 2 Choung CB, Wilson SP the risks in a complex environment. Environmental Pollution 157 (11):2903-2927. DOI 10.1016/j.envpol.2009.05.015.

IIA 8.16 Manzoni CG, Grutz- 2006 Side effects of pesticides used in integrated 1 macher AD, Giolo FP, production of apple in adults of Trichogramma Harter WD, Mul- ler C pretiosum. Pesquisa Agrope- cuaria Brasileira 41 (10):1461-1467

IIA 8.16 Marc J, Le Breton M, 2005 A glyphosate-based pesticide impinges on 3 E K Cormier P, Morales transcription. Toxicology and Applied J, Belle R, Mulner- Pharmacology 203 (1):1-8. DOI Lorillon O 10.1016/j.taap.2004.07.014.

IIA 8.16 Marc J, Mulner- Lorillon 2002 Pesticide roundup provokes cell division dysfunction 2 E K O, Boulben S, Hureau D, at the level of CDK1/cyclin B activation. Chemical Durand G, Belle R Research in Toxicology 15 (3):326-331. Doi 10.1021/Tx015543g.

IIA 8.16 Marchand J, Tanguy A, 2006 Molecular identification and expression of 2 Charrier G, Quiniou L, differentially regulated genes of the European Plee- Gauthier E, flounder, Platichthys flesus, submitted to pesticide Laroche J exposure. Mar Bio- technol (NY) 8 (3):275-94. DOI: 10.1007/s10126-005-0099-3.

IIA 8.16 Martin ML, Ronco 2006 Effect of mixtures of pesticides used in the direct 1 AE seeding technique on nontarget plant seeds. Bull Environ Contam Toxicol 77 (2):228-36. DOI: 10.1007/s00128-006-1054- 3.

IIA 8.16 Massenssini AM, Costa 2008 Activity of Phosphate Solubilizing Bacterial Isolates in 1 MD, Reis MR, Silva AA the Presence of Commercial Glyphosate Formulations. Planta Daninha 26 (4):815-823

IIA 8.16 Matarczyk JA, Willis AJ, 2002 Herbicides, weeds and endangered species: 1 Vranjic JA, Ash JE management of bitou bush (Chrysanthemoides monilifera ssp rotundata) with glyphosate and impacts on the endangered shrub, Pimelea spicata. Biologi- cal Conservation 108 (2):133-141

IIA 8.16 Matschke J, Macha- 2002 Changes in the content of indole-3-acetic acid and 2 ckova I cytokinins in spruce, fir and oak trees after herbicide treatment. Biologia Plantarum 45 (3):375-382

IIA 8.16 McComb BC, Curtis L, 2008 Acute toxic hazard evaluations of glyphosate herbicide 1 Chambers CL, Newton on terrestrial vertebrates of the Oregon coast range. M, Bentson K Environ Sci Pollut Res Int 15 (3):266-72

IIA 8.16 McCoy KA, Bortnick LJ, 2008 Agriculture alters gonadal form and function in the 1 Also listed Campbell CM, Hamlin HJ, toad Bufo marinus. Environ Health Perspect 116 under Guillette LJ, St Mary CM (11):1526-32. DOI: IIA 5.10 10.1289/ehp.11536.

IIA 8.16 McCoy KA, Hoang LK, 2008 Renal pathologies in giant toads (Bufo marinus) vary 1 Guillette LJ, Jr., St Mary with land use. Sci Total Envi- ron 407 (1):348-57. CM DOI: 10.1016/j.scitotenv.2008.09.008.

Page 171 of 192

- 172 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 McDaniel TV, 2008 Potential endocrine disruption of sexual development 1 Also listed Martin PA, Struger J, in free ranging male northern leopard frogs (Rana under Sherry J, Marvin CH, pipiens) and green frogs (Rana clamitans) from areas IIA 5.10 McMaster ME, Clarence of intensive row crop agriculture. Aquat Toxicol 88 S, Tetreault G (4):230- 42. DOI: 10.1016/j.aquatox.2008.05.002.

IIA 8.16 McMullin RT, Bell 2012 The effects of triclopyr and glyphosate on lichens. 1 FW, Newmaster SG Forest Ecology and Management 264:90-97. doi: 10.1016/j.foreco.2011.09.039.

IIA 8.16 Means NE, Kremer 2007 Influence of soil moisture on root colonization of 1 RJ glyphosate-treated soybean by Fusarium species. Communications in Soil Science and Plant Analysis 38 (13- 14):1713-1720. Doi 10.1080/00103620701435472.

IIA 8.16 Means NE, Kremer 2007 Effects of glyphosate and foliar amendments on 1 RJ, Ramsier C activity of microorganisms in the soybean rhizosphere. J Environ Sci Health B 42 (2):125-32. DOI: 10.1080/03601230601123227. IIA 8.16 Melhoranca Filho AL, 2011 Effect Of Subdoses Glyphosate On The Germination 1 Pereira MRR, Martins Of Seeds Of Soybean Cultivars RR And D Conventional. Bioscience Journal 27 (5):686-691

IIA 8.16 Melnichuk SD, 2007 Effects of Fakel herbicide on vital activity of 1 Scherban YP, Lok- Ceriodaphnia affinis in acute and chronic experiments. hanskaya VI Hydrobiological Journal 43 (6):83-91. doi: 10.1615/HydrobJ.v43.i6.70.

IIA 8.16 Mendes D, Pitelli 2004 Effect of herbicide concentrations on biological 1 RA, Coelho L aspects of Fusarium sp. (isolation FCAV#940). Planta Daninha 22 (1):85-93 IIA 8.16 Menendez-Helman RJ, 2012 Glyphosate as an Acetylcholinesterase Inhibitor in 2 Also listed Ferreyroa GV, dos Cnesterodon decemmaculatus. Bulletin of under Santos Afonso M, Environmental Contamination and Toxicology 88 IIA 5.10 Salibian A (1):6-9. doi: 10.1007/s00128-011-0423-8.

IIA 8.16 Menezes C, Fonseca M, 2011 Roundup Effects on Oxidative Stress 3 K Loro V, Santi A, Parameters and Recovery Pattern of Cattaneo R, Clasen B, Rhamdia quelen. Archives of Environmental Pretto A, Morsch V Contamination and Toxicology 60 (4):665- 671. DOI: 10.1007/s00244-010-9574-6.

IIA 8.16 Mensah PK, Muller 2011 Acute toxicity of Roundup® herbicide to three life 3 K WJ, Palmer CG stages of the freshwater shrimp Caridina nilotica (Decapoda: Atyidae). Physics and Chemistry of the Earth, Parts A/B/C 36 (14–15):905-909. DOI: 10.1016/j.pce.2011.07.071.

IIA 8.16 Meriles JM, Gil SV, 2008 Selected soil-borne fungi under glyphosate 1 Haro RJ, March GJ, application and crop residues from a long- term field Guzman CA experiment. Biological Agricultu- re & Horticulture 26:193-205

IIA 8.16 Meriles JM, Gil SV, 2006 Glyphosate and previous crop residue effect on 2 Haro RJ, March GJ, deleterious and beneficial soil-borne fungi from a Guzman CA peanut-corn-soybean rotations. Journal of Phytopathology 154 (5):309-316

Page 172 of 192

- 173 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Michalková V, Pekár 2009 How glyphosate altered the behaviour of agrobiont 1 S spiders (Araneae: Lycosidae) and beetles (Coleoptera: Carabidae). Biological Control 51 (3):444-449

IIA 8.16 Michel A, Johnson RD, 2004 Dose-response relationships between herbicides 1 Duke SO, Scheffler BE with different modes of action and growth of Lemna paucicostata: An improved ecotoxicological method. Envi- ronmental Toxicology and Chemistry 23 (4):1074-1079

IIA 8.16 Mijangos I, Becerril JM, 2009 Effects of glyphosate on rhizosphere soil microbial 1 Albizu I, Epelde L, communities under two different plant compositions Garbisu C by cultivation-dependent and -independent methodologies. Soil Bio- logy & Biochemistry 41 (3):505-513. DOI 10.1016/j.soilbio.2008.12.009.

IIA 8.16 Milosevic NA, Go- 2002 Effect of herbicides on microbiological properties 1 vedarica MM of soil. Proceedings for Natural Sciences (Matica Srpska Nove Sad) 102 (5):21

IIA 8.16 Mirande L, Haram- boure 2010 Side-effects of glyphosate on the life parameters of 3 K M, Smagghe G, Pineda S, Eriopis connexa (Coleoptera: Coccinelidae) in Schnei- der MI Argentina. Commun Agric Appl Biol Sci 75 (3):367- 72

IIA 8.16 Miteva LPE, Ivanov 2010 Alterations in glutathione pool and some related 1 SV, Alexieva VS enzymes in leaves and roots of pea plants treated with the herbicide glyphosate. Russian Journal of Plant Physiology 57 (1):131-136. doi: 10.1134/s1021443710010188.

IIA 8.16 Modesto KA, Marti- nez 2010 Roundup® causes oxidative stress in liver and 1 CBR inhibits acetylcholinesterase in muscle and brain of the fish Prochilodus lineatus. Chemosphere 78 (3):294-299. DOI: 10.1016/j.chemosphere.2009.10.047.

IIA 8.16 Modesto KA, Marti- nez 2010 Effects of Roundup Transorb on fish: Hematology, 2 CBR antioxidant defenses and acetylcholinesterase activity. Chemosphere 81 (6):781-787. DOI: 10.1016/j.chemosphere.2010.07.005.

IIA 8.16 Mohamed AH 2011 Sublethal toxicity of Roundup to immunological and 3 K molecular aspects of Biomphalaria alexandrina to Schistosoma mansoni infection. Ecotoxicology and Envi- ronmental Safety 74 (4):754-760. DOI: 10.1016/j.ecoenv.2010.10.037.

IIA 8.16 Moldes CA, Camiña JM, 2012 Physiological effects of glyphosate over amino acid 2 Medici LO, Tsai SM, profile in conventional and transgenic soybean Azevedo RA (Glycine max). Pesticide Biochemistry and Physiology. doi: 10.1016/j.pestbp.2011.12.004.

IIA 8.16 Moldes CA, Medici LO, 2008 Biochemical responses of glyphosate resistant and 1 Abrahao OS, Tsai SM, susceptible soybean plants exposed to glyphosate. Azevedo RA, Tsai SM Acta Physiologiae Plantarum 30 (4):469-479. doi: 10.1007/s11738-008-0144-8.

Page 173 of 192

- 174 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Moore LJ, Fuentes L, 2012 Relative toxicity of the components of the original 1 Rodgers Jr JH, Bowerman formulation of Roundup® to five North American WW, Yarrow GK, Chao anurans. Ecotoxicology and Environmental Safety. WY, Bridges Jr WC doi: 10.1016/j.ecoenv.2011.11.025.

IIA 8.16 Moreno B, Garcia- 2009 Rainfed olive farming in south-eastern Spain: Long- 1 Rodriguez S, Canizares term effect of soil management on biological R, Castro J, Benitez E indicators of soil quality. Agri- culture Ecosystems & Environment 131 (3- 4):333-339. DOI 10.1016/j.agee.2009.02.011.

IIA 8.16 Morjan WE, Pedigo 2002 Fungicidal effects of glyphosate and glyphosate 1 LP, Lewis LC formulations on four species of entomopathogenic fungi. Environmental Entomology 31 (6):1206- 1212

IIA 8.16 Motavalli PP, Kre- mer 2004 Impact of genetically modified crops and their 1 Also listed RJ, Fang M, Means NE management on soil microbially mediated plant under nutrient transformations. Journal of IIA 7.13 Environmental Quality 33 (3):816-824

IIA 8.16 Mugni H, Ronco A, 2011 Insecticide toxicity to Hyalella curvispina in runoff 1 Bonetto C and stream water within a soybean farm (Buenos Aires, Argentina). Ecotoxico- logy and Environmental Safety 74 (3):350- 354. DOI: 10.1016/j.ecoenv.2010.07.030.

IIA 8.16 Nakamura A, Catterall 2008 Effects of glyphosate herbicide on soil and litter 1 CP, Kitching RL, House macro-arthropods in rainforest: Implications for APN, Burwell CJ forest restoration. Ecologi- cal Management & Restoration 9 (2):126- 133. DOI: 10.1111/j.1442- 8903.2008.00404.x.

IIA 8.16 Nandula VK, Reddy KN, 2007 Glyphosate-resistant and -susceptible soybean 1 Rimando AM, Duke SO, (Glycine max) and canola (Brassica napus) dose Poston DH response and metabolism relationships with glyphosate. Journal of Agricultural and Food Chemistry 55 (9):3540-3545. doi: 10.1021/jf0635681.

IIA 8.16 Negga R, Rudd DA, 2011 Exposure to Mn/Zn ethylene-bis- dithiocarbamate 1 (8.16) Also listed Davis NS, Justice AN, and glyphosate pesticides leads to 3 (5.10) under Hatfield HE, Valente neurodegeneration in Caenorhabditis elegans. IIA 5.10 AL, Fields AS, NeuroToxicology Fitsanakis VA 32 (3):331-341. DOI: 10.1016/j.neuro.2011.02.002.

IIA 8.16 Nelson KA, Renner KA, 2002 Cultivar and herbicide selection affects soybean 1 Hammerschmidt R development and the incidence of Sclerotinia stem rot. Agronomy Journal 94 (6):1270-1281

IIA 8.16 Njiti VN, Myers Jr. O, 2003 Roundup Ready Soybean: Glyphosate Effects on 1 Schroeder D, Lightfoot Fusarium solani Root Colonization and Sudden DA Death Syndrome. Agron. J. 95 (1140-1145)

IIA 8.16 Noel GR, Wax LM 2009 Heterodera glycines population development on 1 soybean treated with glyphosate. Ne- matropica 39 (2):247-253

Page 174 of 192

- 175 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Nornberg SD, 2008 Selectivity of glyphosate formulations applied 1 Grutzmacher AD, on miniature stages of Giolo FP, Junior GJE, Trichogramma pretiosum. Planta Daninha 26 (3):611- Lima CAB, 617 Grutzmacher DD

IIA 8.16 Oliveira AG, Telles LF, 2007 Effects of the herbicide Roundup on the epididymal 3 K Also listed Hess RA, Mahecha GA, region of drakes Anas platyrhynchos. Reprod under Oliveira CA Toxicol 23 (2):182- IIA 5.10 91. DOI: 10.1016/j.reprotox.2006.11.004.

IIA 8.16 Olszyk D, Pfleeger T, 2010 Potato (Solanum Tuberosum) Greenhouse Tuber 2 Lee EH, Plocher M Production as an Assay for Asexual Reproduction Effects from Herbicides. Envi- ronmental Toxicology and Chemistry 29 (1):111-121. Doi 10.1002/Etc.12.

IIA 8.16 Olszyk DM, Curdick 2004 Assessing the risks to non-target terrestrial plants 1 CA, Pfleeger TG, Lee from herbicides. J Agric Meteorol 60 (4):221-242 EH, Watrud LS IIA 8.16 Olurin KB, Olojo 2006 Histopathological responses of the gill and liver 2 EAA, Mbaka GO, tissues of Clarias gariepinus fingerlings to herbicide, Akindele AT glyphosate. African Journal of Biotechnology 5(24): 2480-2487 5 (24):2480-2487

IIA 8.16 Ortiz BV, Thomson SJ, 2011 Determination of differences in crop injury from 1 Huang Y, Reddy KN, aerial application of glyphosate using vegetation Ding W indices. Computers and Electro- nics in Agriculture 77 (2):204-213. DOI: 10.1016/j.compag.2011.05.004.

IIA 8.16 Ortiz-Ordoñez E, 2011 Effect of Yerbimat Herbicide on Lipid Peroxidation, 1 Uría-Galicia E, Ruiz- Catalase Activity, and Histological Damage in Gills Picos R, Sánchez Duran and Liver of the Freshwater Fish Goodea Atripinnis. A, Hernández Trejo Y, Archives of Environmental Contamination and Sedeño- Díaz J, López- Toxicology 61 (3):443-452. DOI: López E 10.1007/s00244-011-9648-0. IIA 8.16 Ortiz-Santaliestra M, 2011 Influence of a Combination of Agricultural 2 Fernández-Benéitez M, Chemicals on Embryos of the Endangered Gold- Lizana M, Marco A Striped Salamander (Chioglossa lusitanica). Archives of Environmental Contamination and Toxicology 60 (4):672-680. DOI: 10.1007/s00244-010-9570-x.

IIA 8.16 Ouyang F 2010 Experimental Study on the Acute Toxicity of 2 Two Pesticides to Rana Catesbeiana Tadpole. Journal of Xinxiang University (Natural Science Edition) 27 (4):63-64

IIA 8.16 Pankey JH, Griffin JL, 2005 Preemergence herbicide and glyphosate effects on 1 Colyer PD, Schneider seedling diseases in glyphosate- resistant cotton. RW, Miller DK Weed Technology 19 (2):312-318

IIA 8.16 Papchenkova G, 2009 The parameters of reproduction, sizes, and activities 2 Golovanova I, of hydrolases in Daphnia magna Ushakova N straus of successive generations affected by Roundup herbicide. Inland Water Biology 2 (3):286-291. DOI: 10.1134/s1995082909030158.

Page 175 of 192

- 176 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Pasaribu A, Mohamad 2011 Growth and development of symbiotic Arbuscular 1 RB, Awang Y, Othman mycorrhizal fungi, Glomus mossea (Nicol. and R, Puteh A Gerd.), in alachlor and glyphosate treated soils. African Journal of Biotechnology 10 (55):11520- 11526

IIA 8.16 Pereira JL, Antunes SC, 2009 Toxicity evaluation of three pesticides on non- 1 Castro BB, Marques CR, target aquatic and soil organisms: commercial Goncalves AMM, formulation versus active ingredient. Ecotoxicology Goncalves F, Pereira R 18 (4):455-463. DOI 10.1007/s10646-009-0300-y.

IIA 8.16 Perez GL, Torremorell A, 2007 Effects of the herbicide Roundup on freshwater 1 Mugni H, Rodriguez P, microbial communities: a mesocosm study. Ecol Solange Vera M, do Appl 17 (8):2310-22 Nascimento M, Allende L, Bustingorry J, Escaray R, Ferraro M, Izaguirre I, Pizarro H, Bonetto C, Morris DP, Zagarese H

IIA 8.16 Perez GL, Vera MS, 2011 Effects of Herbicide Glyphosate and Glyphosate- 1 Miranda LA Based Formulations on Aquatic Ecosystems. In Herbicides and Environment, edited by Kortekamp. Croatia. InTech. Chapter 16. pp 343 - 368.

IIA 8.16 Pesce S, Batisson I, 2009 Response of spring and summer riverine microbial 1 Bardot C, Fajon C, communities following glyphosate exposure. Portelli C, Montuelle B, Ecotoxicol Environ Saf 72 (7):1905-12. DOI: Bohatier J 10.1016/j.ecoenv.2009.07.004.

IIA 8.16 Pesce S, Fajon C, Bardot 2008 Longitudinal changes in microbial planktonic 2 Also listed C, Bonnemoy F, Portelli communities of a French river in relation to pesticide under C, and nutrient inputs. Aquat Toxicol 86 (3):352-60. IIA 7.13 Bohatier J DOI: 10.1016/j.aquatox.2007.11.016.

IIA 8.16 Pettersson M, Eke- lund 2006 Effects of the herbicides roundup and avans on 1 NGA Euglena gracilis. Archives of Environ- mental Contamination and Toxicology 50 (2):175-181. DOI 10.1007/s00244-004- 0042-z.

IIA 8.16 Pfleeger T, Olszyk D, 2011 Comparing Effects of Low Levels of Herbicides on 3 K Lee EH, Plocher M Greenhouse- and Field-Grown Potatoes (Solanum Tuberosum L.), Soybeans (Glycine Max L.), and Peas (Pisum Sativum L.). Environmental Toxico- logy and Chemistry 30 (2):455-468. Doi 10.1002/Etc.394.

IIA 8.16 Pfleeger T, Olszyk 2008 Effects of low concentrations of herbicides on full- 1 D, Plocher M, Yilma season, field-grown potatoes. J Envi- ron Qual 37 S (6):2070-82. DOI: 10.2134/jeq2007.0376.

IIA 8.16 Pierre J, Marsault D, 2003 Effects of herbicide-tolerant transgenic oilseed rape 1 Genecque E, Renard M, genotypes on honey bees and other pollinating Champolivier J, Pham- insects under field conditions. Entomologia Delegue MH Experimentalis Et Applicata 108 (3):159-168

Page 176 of 192

- 177 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Piesova E 2005 The effect of glyphosate on the frequency of 1 Also listed micronuclei in bovine lymphocytes in vitro. Acta under Veterinaria-Beograd 55 (2-3):101-109 IIA 5.10

IIA 8.16 Piha H, Pekkonen M, 2006 Morphological Abnormalities in Amphibians in 3 K Merilä J Agricultural Habitats: A Case Study of the Common Frog Rana remporaria. Copeia 4: 810-817 4:810-817. DOI: 10.1643/0045- 8511.

IIA 8.16 Piotrowicz-Cieslak AI, 2010 Different Glyphosate Phytotoxicity of Seeds and 3 K Adomas B, Mi- Seedlings of Selected Plant Species. Polish Journal of chalczyk DJ Environmental Studies 19 (1):123-129

IIA 8.16 Pline WA, Wilcut JW, 2002 Physiological and morphological response of 3 K Edmisten KL, Wells R glyphosate-resistant and non-glyphosate- resistant cotton seedlings to root-absorbed glyphosate. Pesticide Biochemistry and Physiology 73 (1):48-58

IIA 8.16 Poletta GL, Kleinsorge 2011 Genetic, enzymatic and developmental alterations 1 E, Paonessa A, Mudry observed in Caiman latirostris exposed in ovo to MD, Larriera A, Siroski pesticide formulations and mixtures in an experiment PA simulating environmental exposure. Ecotoxicology and Environmental Safety 74 (4):852-859. DOI: 10.1016/j.ecoenv.2010.12.005.

IIA 8.16 Poletta GL, Larriera A, 2009 Genotoxicity of the herbicide formulation Roundup 3 (8.16) K Also listed Kleinsorge E, Mudry (R) (glyphosate) in broad-snouted caiman (Caiman 2 (5.10) under MD latirostris) evidenced by the Comet assay and the IIA 5.10 Micronucleus test. Mutation Research-Genetic Toxicology and Environmental Mutagenesis 672 (2):95-102. DOI 10.1016/j.mrgentox.2008.10.007.

IIA 8.16 Powell JR, Campbell RG, 2009 Effect of glyphosate on the tripartite symbiosis 1 Dunfield KE, Gulden RH, formed by Glomus intraradices, Bradythizobium Hart MM, Levy-Booth japonicum, and genetically modified soybean. DJ, Klironomos JN, Applied Soil Ecology 41 (1):128-136. DOI Pauls KP, Swanton CJ, 10.1016/j.apsoil.2008.10.002. Trevors JT, An- tunes PM

IIA 8.16 Powell JR, Levy- Booth 2009 Effects of genetically modified, herbicide- tolerant 1 DJ, Gulden RH, Asbil crops and their management on soil food web WL, Campbell RG, Dun- properties and crop litter decomposition. Journal of field KE, Hamill AS, Hart Applied Ecology MM, Lerat S, Nurse RE, 46 (2):388-396. DOI 10.1111/j.1365- Pauls KP, Sikkema PH, 2664.2009.01617.x. Swan- ton CJ, Trevors JT, Klironomos JN

IIA 8.16 Powell JR, Swanton 2008 A critique of studies evaluating glyphosate effects on 2 CJ diseases associated with Fusarium spp. Weed Research 48 (4):307-318

Page 177 of 192

- 178 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Progar RA, Markin G, 2010 Inundative Release of Aphthona spp. Flea Beetles 1 Milan J, Barbou- letos T, (Coleoptera: Chrysomelidae) as a Biological Rinella MJ “Herbicide” on Leafy Spurge in Riparian Areas. Journal of Economic Ento- mology 103 (2):242-248. DOI: 10.1603/ec09294.

IIA 8.16 Puertolas L, Damasio J, 2010 Evaluation of side-effects of glyphosate mediated 2 Also listed Barata C, Soares AM, Prat control of giant reed (Arundo donax) on the structure under N and function of a nearby Mediterranean river IIA 7.13 ecosystem. Envi- ron Res 110 (6):556-64. DOI: 10.1016/j.envres.2010.05.004.

IIA 8.16 Puglis H, Boone M 2011 Effects of Technical-Grade Active Ingredient vs. 2 Commercial Formulation of Seven Pesticides in the Presence or Absence of UV Radiation on Survival of Green Frog Tadpoles. Archives of Environmental Con- tamination and Toxicology 60 (1):145-155. DOI: 10.1007/s00244-010-9528-z.

IIA 8.16 Quaranta A, Bellantuono 2009 Why Amphibians Are More Sensitive than 1 V, Cassano G, Lippe C Mammals to Xenobiotics. PLoS ONE 4 (11):e7699

IIA 8.16 Quassinti L, Maccari 2009 Effects of paraquat and glyphosate on 1 Also listed E, Murri O, steroidogenesis in gonads of the frog Rana under Bramucci M esculenta in vitro. Pesticide Biochemistry and IIA 5.10 Physiology 93 (2):91-95. DOI 10.1016/j.pestbp.2008.11.006.

IIA 8.16 Raipulis J, Toma M, 2009 Toxicity and genotoxicity testing of Roundup. 2 Also listed Balode M Proceedings of the Latvian Academy of Sciences. under Section B. Natural, Exact, and Applied Sciences. 63 IIA 5.10 (1-2):29-32. doi: 10.2478/v10046-009-0009-6.

IIA 8.16 Ramah K 2011 Histopathological study on the effect of rice 1 herbicides on grass carp (Ctenopharyngodan idella). African Journal of Biotechnology 10 (7):1112-1116

IIA 8.16 Ramírez DW, Ron- dón 2009 Acute toxicity and histopathological lesions in silver 2 BI, Vidal BH, Eslava Pacu (Piaractus brachypomus) exposed to a mixture MP of the herbicide Roundup and the surfactant Cosmoflux 411F. Revista MVZ Cordoba 14 (1):1563- 1575 DOI: 10.1371/journal.pone.0007699.

IIA 8.16 Ramírez-Duarte WF, 2008 Acute toxicity and histopathological alterations of 2 Rondón-Barragán IS, Roundup® herbicide on "cachama blanca" (Piaractus Eslava-Mocha PR brachypomus). Pesquisa Veterinária Brasileira 28:547-554. DOI: 10.1590/S0100- 736X2008001100002.

IIA 8.16 Ratcliff AW, Busse 2006 Changes in microbial community structure following 1 MD, Shestak CJ herbicide (glyphosate) additions to forest soils. Applied Soil Ecology 34 (2- 3):114-124. DOI 10.1016/j.apsoil.2006.03.002.

Page 178 of 192

- 179 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Ray P, Sushilkumar, 2008 Deleterious effect of herbicides on waterhyacinth 1 Pandey AK biocontrol agents Neochetina bruchi and Alternaria alternata. Biocontrol Science and Technology 18 (5):523-533. Doi 10.1080/09583150802001734.

IIA 8.16 Reddy KN, Abbas 2007 Mycotoxin occurrence and Aspergillus flavus soil 1 HK, Zablotowicz propagules in a corn and cotton glyphosate-resistant RM, Abel CA, Koger cropping systems. Food Addit Contam 24 (12):1367- CH 73. DOI: 10.1080/02652030701509964.

IIA 8.16 Reddy KN, Bellaloui 2010 Glyphosate effect on shikimate, nitrate reductase 2 K Also listed N, Zablotowicz RM activity, yield, and seed composition in corn. J Agric under Food Chem 58 (6):3646-50. DOI: IIA 7.13 10.1021/jf904121y.

IIA 8.16 Reddy KN, Rimando 2004 Aminomethylphosphonic acid, a metabolite of 3 E K AM, Duke SO glyphosate, causes injury in glyphosate- treated, glyphosate-resistant soybean. Jour- nal of Agricultural and Food Chemistry 52 (16):5139-5143. Doi 10.1021/Jf049605v.

IIA 8.16 Reddy SR 2010 Effect of Herbicides on Mycoflora of Rice Field 1 Soils. Journal of Mycology and Plant Pathology 40 (3):450-453 IIA 8.16 Reis MR, Silva AA, J.L. 2010 Impact of Glyphosate Associated with 1 P, Freitas MAM, Costa Endosulphan and Tebuconazole on the MD, Silva MCS, Santos Endosymbiotic Microorganisms of the Soybean. EA, Franca AC, Ferreira Planta Daninha 28 (1):113-121 GL

IIA 8.16 Relyea R, Hoverman 2006 Assessing the ecology in ecotoxicology: a review and 3 K J synthesis in freshwater systems. Ecology Letters 9 (10):1157-1171. DOI 10.1111/j.1461-0248.2006.00966.x.

IIA 8.16 Relyea RA 2011 Amphibians Are Not Ready for Roundup, edited by 1 J. E. Elliott, C. A. Bishop and C. A. Morrissey. Springer New York. pp 267- 300. DOI: 10.1007/978-0-387-89432-4_9.

IIA 8.16 Relyea RA 2009 A cocktail of contaminants: how mixtures of 1 pesticides at low concentrations affect aquatic communities. Oecologia 159 (2):363-76. DOI: 10.1007/s00442-008-1213- 9.

IIA 8.16 Relyea RA 2004 Growth and survival of five amphibian species 3 K exposed to combinations of pesticides. Environmental Toxicology and Chemistry 23 (7):1737-1742

IIA 8.16 Relyea RA 2005 The impact of insecticides and herbicides on the 3 K biodiversity and productivity of aquatic communities. Ecological Applications 15 (2):618-627

IIA 8.16 Relyea RA 2005 The lethal impact of roundup on aquatic and 3 K terrestrial amphibians. Ecological Applicati- ons 15 (4):1118-1124

Page 179 of 192

- 180 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Relyea RA 2005 The lethal impacts of roundup and predatory stress on 3 K six species of North American tadpoles. Archives of Environmental Con- tamination and Toxicology 48 (3):351-357. DOI 10.1007/s00244-004-0086-0.

IIA 8.16 Relyea RA 2012 New effects of Roundup on amphibians: Predators 3 K reduce herbicide mortality; herbicides induce antipredator morphology. Ecological Applications 22 (2):634-647. DOI: 10.1890/11-0189.1.

IIA 8.16 Relyea RA, Jones 2009 The Toxicity of Roundup Original Max (R) to 13 2 DK Species of Larval Amphibians. Envi- ronmental Toxicology and Chemistry 28 (9):2004-2008

IIA 8.16 Relyea RA, 2005 Pesticides and amphibians: The importance of 3 K Schoeppner NM, community context. Ecological Applicati- ons 15 Hoverman JT (4):1125-1134 IIA 8.16 Renaud A, Poinsot- 2004 Influence of four soil maintenance practices on 2 Balaguer N, Cortet J, Le Collembola communities in a Mediterranean vineyard. Petit J Pedobiologia 48 (5- 6):623-630. DOI 10.1016/j.pedobi.2004.07.002.

IIA 8.16 Rigoli RP, Fontana LC, 2008 Response of beetroot (Beta vulgaris) and carrot 1 Figueredo SS, Noldin (Daucus carota) to simulated glyphosate and JA clomazone drift. Planta Da- ninha 26 (2):451-456

IIA 8.16 Rivera D, Camelo M, 2010 Different pesticides’ effect on Azotobacter 1 Estrada G, Obando chroococcum growth. Rev. Colomb. Biotec- nol. XII M, Bonilla R (1):94-102 IIA 8.16 Rizzardi MA, Fleck NG, 2003 Herbicide action in plant defence mechanisms to 2 Agostinetto D, Balbinot pathogens. Ciencia Rural, Santa Maria 33 (5):957- Jr AA 965 IIA 8.16 Roberts CW, Roberts F, 2002 The shikimate pathway and its branches in 1 Lyons RE, Kirisits MJ, apicomplexan parasites. Journal of Infecti- ous Mui EJ, Finnerty J, Diseases 185:S25-S36 Johnson JJ, Fergu- son DJP, Coggins JR, Krell T, Coombs GH, Milhous WK, Kyle DE, Tzipori S, Barnwell J, Dame JB, Carlton J, McLe- od R

IIA 8.16 Rodriguez AM, Ja- 2010 Glyphosate effects on floristic composition and 1 cobo EJ species diversity in the Flooding Pampa grassland (Argentina). Agriculture, Ecosys- tems & Environment 138 (3–4):222- 231. DOI: 10.1016/j.agee.2010.05.003.

IIA 8.16 Rohr JR, Raffel TR, 2008 Understanding the net effects of pesticides on 2 Sessions SK, Hudson PJ amphibian trematode infections. Ecol Appl 18 (7):1743-53

Page 180 of 192

- 181 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Rombke J, 2008 Risk assessment of pesticides for soils of the Central 1 Waichman AV, Amazon, Brazil: comparing outcomes with temperate Garcia MV and tropical data. Integr Environ Assess Manag 4 (1):94-104. DOI: 10.1897/IEAM_2007-052.

IIA 8.16 Romero DM, Rios de 2011 Oxidative stress induced by a commercial glyphosate 2 Molina MC, Juarez AB formulation in a tolerant strain of Chlorella kessleri. Ecotoxicol Environ Saf 74 (4):741-7. DOI: 10.1016/j.ecoenv.2010.10.034.

IIA 8.16 Ronco MG, Ruscitti ME, 2008 Glyphosate and mycorrhization induce changes in 2 Arango MC, Beltrano J plant growth and in root morphology and architecture in pepper plants (Capsicum annuum L.). Journal of Horticultural Science & Biotechnology 83 (4):497-505

IIA 8.16 Rosa DD, Basseto 2010 Effect of herbicides on phytopathogenic agents. 1 MA, Cavariani C, Acta Scientiarum-Agronomy 32 (3):379-383. Furtado EL doi: 10.4025/actasciagron.v32i3.3728.

IIA 8.16 Rossi SC, da Silva MD, 2011 Sublethal Effects of Waterborne Herbicides in 1 Piancini LDS, Ribeiro Tropical Freshwater Fish. Bulletin of Environmental CAO, Cestari MM, de Contamination and Toxico- logy 87 (6):603-607. doi: Assis HCS 10.1007/s00128- 011-0397-6.

IIA 8.16 Ruan Z-X, Brown 2008 Effects of acute glyphosate exposure on the growth 1 MT and physiology of Nostoc sphaeroides, an edible cyanobacterium of paddy rice fields. Acta Hydrobiologica Sini- ca [Shuisheng shengwuxue jikan] 32 (4):462-468

IIA 8.16 Ruzkova M, Ruzek L, 2011 Microbiological characterization of land set- aside 2 Vorisek K, Vra- blik P, before and after Roundup desiccation. Plant Soil and Musilova D Environment 57 (2):88-94 IIA 8.16 Saenz ME, Di 2009 Ecotoxicity of herbicide Glyphosate to four 2 Marzio WD chlorophyceaen freshwater algae. Limnetica 28 (1):149-158 IIA 8.16 Salbego J, Pretto A, 2010 Herbicide formulation with glyphosate affects growth, 3 K Gioda CR, de Mene- zes acetylcholinesterase activity, and metabolic and CC, Lazzari R, Radunz hematological parameters in piava (Leporinus Neto J, Bal- disserotto B, obtusidens). Arch Envi- ron Contam Toxicol 58 Loro VL (3):740-5. DOI: 10.1007/s00244-009-9464-y.

IIA 8.16 Salvagni J, Ternus 2011 Assessment of the genotoxic impact of pesticides on 2 Also listed RZ, Fuentefria AM farming communities in the countryside of Santa under Catarina State, Brazil. Genetics and Molecular IIA 5.10 Biology 34 (1):122- 126

IIA 8.16 Sanchez D, Graca 2007 Testing the use of the water milfoil (Myriophyllum 3 K MAS, Canhoto J spicatum l.) in laboratory toxicity assays. Bulletin of Environmental Contamination and Toxicology 78 (6):421- 426. DOI 10.1007/s00128-007-9131-9.

Page 181 of 192

- 182 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Sanchez W, Piccini B, 2010 Comparison of two reference systems for biomarker 2 Maillot-Marechal E, data analysis in a freshwater biomonitoring context. Porcher JM Environment Interna- tional 36 (4):377-382. DOI 10.1016/j.envint.2010.02.006.

IIA 8.16 Sandermann H 2006 Plant biotechnology: ecological case studies on 2 herbicide resistance. Trends Plant Sci 11 (7):324-8. DOI: 10.1016/j.tplants.2006.05.004.

IIA 8.16 Sanogo S, Yang XB, 2001 Field response of glyphosate-tolerant soybean to 1 Lundeen P herbicides and sudden death syndrome. Plant Disease 85 (7):773-779 IIA 8.16 Santos JB, Jacques RJS, 2004 Effects of different glyphosate commercial 2 Procopio SO, Kasuya formulations on the Bradyrhizobium strains. Planta MCM, Silva A, Santos Daninha Vicosa-MG 22 (2):293-299 EA

IIA 8.16 Santos MJG, Morgado R, 2011 Evaluation of the joint effect of glyphosate and 1 Ferreira NGC, Soares dimethoate using a small-scale terrestrial ecosystem. AMVM, Loureiro S Ecotoxicology and Environmen- tal Safety 74 (7):1994-2001. DOI: 10.1016/j.ecoenv.2011.06.003.

IIA 8.16 Santos MJG, Soares 2010 Joint effects of three plant protection products 1 AMVM, Loureiro S to the terrestrial isopod Porcellionides pruinosus and the collembolan Folsomia candida. Chemosphe- re 80 (9):1021-1030. DOI: 10.1016/j.chemosphere.2010.05.031.

IIA 8.16 Sanyal D, Shrestha A 2008 Direct Effect of Herbicides on Plant Pathogens and 1 Disease Development in Various Cropping Systems. Weed Science 56 (1):155-160. doi: 10.1614/ws-07-081.1.

IIA 8.16 Sarigul Z, Bekcan S 2009 Acute Toxicity of The Herbicide Glyphosate on 3 K T Daphnia magna. Tarim Bilimeri Derigisi - Journal of Agricultural Sciences 15 (2):204- 208

IIA 8.16 Savin MC, Purcell LC, 2009 Response of Mycorrhizal Infection to Glyphosate 1 Daigh A, Manfredini A Applications and P Fertilization in Glyphosate- Tolerant Soybean, Maize, and Cotton. Journal of Plant Nutrition 32 (10):1702-1717

IIA 8.16 Saxton MA, Morrow EA, 2011 Glyphosate influence on phytoplankton community 1 Bourbonniere RA, structure in Lake Erie. Journal of Great Lakes Wilhelm SW Research 37 (4):683-690. doi: 10.1016/j.jglr.2011.07.004.

IIA 8.16 Schier A 2006 Field study on the occurrence of ground beetles and 1 spiders in genetically modified, herbicide tolerant corn in conventional and conservation tillage systems. Journal of Plant Diseases and Protection. Special Edition XX:101-113

Page 182 of 192

- 183 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Schneider MI, San- chez 2009 Impact of glyphosate on the development, fertility 1 N, Pineda S, Chi H, and demography of Chrysoperla externa Ronco A (Neuroptera: Chrysopidae): ecological approach. Chemosphere 76 (10):1451-5. DOI: 10.1016/j.chemosphere.2009.05.029.

IIA 8.16 Sebiomo A, Ogunde- ro 2011 Effect of four herbicides on microbial population, 2 VW, Bankole SA soil organic matter and dehydrogenase activity. African Journal of Biotechnology 10 (5):770-778

IIA 8.16 Shen HR, Zhou 2002 Effects of 6 herbicides on Rhizoctonia solani AG-1-IA 1 EXQ, P.K. [English translation of Chinese title]. Acta Phytophylacica Sinica 29 (3):249-253

IIA 8.16 Shimina VS, Neela- 2010 Effect of herbicide Excel Mera-71 (glyphosate) 1 megam R treatment on seed germination and early seedling growth of Black gram (Vigna mungo, Hepper.) var T-9. Ad. Plant Sci. 23 (11):515-518

IIA 8.16 Shiogiri NS, Carra- schi 2010 Ecotoxicity of glyphosate and aterbane® br surfactant 1 SP, Cubo P, Schiavetti on guaru (Phalloceros caudimaculatus). Ad. Plant Sci. BL, da Cruz C, Pitelli 23 (11):515- RA 518

IIA 8.16 Smith BC, Curran CA, 2004 Toxicity of four surfactants to juvenile rainbow trout: 2 Brown KW, Cabarrus JL, Implications for use over water. Bulletin of Gown JB, McIntyre JK, Environmental Contami- nation and Toxicology 72 Moreland EE, Wong VL, (3):647-654. DOI Grassley JM, Grue CE 10.1007/s00128-004-0292-5.

IIA 8.16 Smith GR 2001 Effects of acute exposure to a commercial formulation 2 of glyphosate on the tadpoles of two species of anurans. Bulletin of Envi- ronmental Contamination and Toxicology 67 (4):483-488

IIA 8.16 Soares RM, Gazziero 2008 Glyphosate application on soybean rust control. 1 DLP, Morita DAD, Pesquisa Agropecuaria Brasileira 43 (4):473-477 Ciliato ML, Flausino AM, Santos LCM, Janegitz T

IIA 8.16 Sobrero C, Martin 2007 Phytotoxicity of the Roundup (R) Max herbicide on 3 K ML, Ronco A the non-target species Lemna gibba in field and laboratory studies. Hidro- biologica 17 (1):31-39

IIA 8.16 Sobrero MC, Rimoldi 2007 Effects of the glyphosate active ingredient and a 3 K F, Ronco AE formulation on Lemna gibba L. at different exposure levels and assessment end-points. Bull Environ Contam Toxicol 79 (5):537- 43. DOI: 10.1007/s00128-007-9277- 5.

Page 183 of 192

- 184 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Solomon K, R., Anadón 2007 Comparative Hazard Assessment of the Substances 1 Also listed A, Brain Richard A, Used for Production and Control of Coca and Poppy in under Cerdeira Antonio L, Colombia. In Rational Environmental Management of IIA 5.10 Crossan Angus N, Agrochemicals. American Chemical Society. Chapter Marshall J, Sanin L-H, 6. pp 87-99. doi:10.1021/bk-2007- Smith L 0966.ch006.

IIA 8.16 Solomon KR, Anadon A, 2007 Coca and poppy eradication in Colombia: 2 (8.16) Also listed Carrasquilla G, Cerdeira environmental and human health assessment of 1 (5.10) under AL, Marshall J, Sanin LH aerially applied glyphosate. Rev Environ Contam IIA 5.10 Toxicol 190:43-125

IIA 8.16 Solomon KR, 2003 Ecological risk assessment for aquatic 1 Thompson DG organisms from over-water uses of glyphosate. Journal of Toxicology and Environmental Health-Part B-Critical Reviews 6 (3):289-324. Doi 10.1080/15287390390155571.

IIA 8.16 Sorvari J, Jaakkonen 2011 Environmental Risks Caused by Pesticides at Forest 1 Also listed S Nurseries in Finland. Human and Ecological Risk under Assessment 17 (2):431-466. doi: IIA 7.13 10.1080/10807039.2011.552398.

IIA 8.16 Soso AB, Barcellos LJG, 2007 Chronic exposure to sub-lethal concentration of a 3 E K Also listed Ranzani-Paiva MJ, glyphosate-based herbicide alters hormone profiles under Kreutz LC, Quevedo and affects reproduction of female Jundia (Rhamdia IIA 5.10 RM, Anziliero D, Lima quelen). Environ- mental Toxicology and M, da Silva LB, Ritter F, Pharmacology 23 (3):308-313. DOI Bedin AC, Finco JA 10.1016/j.etap.2006.11.008.

IIA 8.16 Soukup J, Holec J, Jursík 2011 Environmental and agronomic monitoring of adverse 1 M, Hamouzo- vá K effects due to cultivation of genetically modified herbicide tolerant crops. Journal für Verbraucherschutz und Lebensmittelsicherheit 6 (0):125-130. DOI: 10.1007/s00003-011-0682-7.

IIA 8.16 Sparling DW, Matson C, 2006 Toxicity of glyphosate as Glypro (R) and LI700 to red- 1 Bickham J, Doelling- eared slider (Trachemys scripta elegans) embryos and Brown P early hatchlings. Envi- ronmental Toxicology and Chemistry 25 (10):2768-2774

IIA 8.16 St. Laurent A, Merwin 2008 Long-term orchard groundcover management 1 IA, Thies JE systems affect soil microbial communities and apple replant disease severity. Plant and Soil 304 (1- 2):209-225. DOI 10.1007/s11104-008-9541-4.

IIA 8.16 Stanghellini ME, Waugh 2004 Crop residue destruction strategies that enhance 1 MM, Rade- wald KC, rather than inhibit reproduction of Monosporascus Kim DH, Ferrin DM, cannonballus. Plant Patho- logy 53 (1):50-53. DOI Turini T 10.1046/j.1365- 3059.2003.00944.x.

Page 184 of 192

- 185 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Stapleton JJ, Summers 2010 Deleterious activity of cultivated grasses (Poaceae) and 1 CG, Mitchell JP, Prather residues on soilborne fungal, nematode and weed TS pests. Phytoparasitica 38 (1):61-69. doi: 10.1007/s12600-009-0070-3.

IIA 8.16 Stefanello GJ, 2008 Selectivity of herbicides registered on corn to 1 Grutzmacher AD, Trichogramma pretiosum (Hymenoptera : Grutmacher DD, Lima Trichogrammatidae). Planta Daninha 26 (2):343-351 CAB, Dalmozo DO, Paschoal MDF

IIA 8.16 Stoleson SH, Ristau TE, 2011 Ten-year response of bird communities to an 1 deCalesta DS, Horsley operational herbicide–shelterwood treatment in a SB northern hardwood forest. Forest Ecolo- gy and Management 262 (7):1205-1214. DOI: 10.1016/j.foreco.2011.06.017.

IIA 8.16 Sullivan TP, Sullivan 2003 Vegetation management and ecosystem disturbance: 1 DS impact of glyphosate herbicide on plant and animal diversity in terrestrial systems. Environ. Rev. 11 (1):37-59. DOI: 10.1139/a03-005.

IIA 8.16 Swift KI, Bell FW 2011 What are the environmental consequences of using 1 Also listed silviculturally effective forest vegetation management under treatments? Forestry Chronicle 87 (2):201-216 IIA 7.13

IIA 8.16 Taccari M, Comitini F, 2011 Toxicity assessment of compounds in soil using a 1 Casucci C, Ciani M simple respirometric technique. In- ternational Biodeterioration & Biode- gradation 65 (1):60- 64. DOI: 10.1016/j.ibiod.2010.02.008.

IIA 8.16 Takahashi M 2007 Oviposition site selection: pesticide avoidance by 1 gray treefrogs. Environ Toxi- col Chem 26 (7):1476- 80 IIA 8.16 Tan WZ, Li QJ, Qing 2002 Biological control of alligatorweed 1 L (Alternanthera philoxeroides) with a Fusarium sp. Biocontrol 47 (4):463-479 IIA 8.16 Tanney JB, Hutchi- son 2010 The effects of glyphosate on the in vitro linear 2 LJ growth of selected microfungi from a boreal forest soil. Can J Microbiol 56 (2):138-44. DOI: 10.1139/w09-122.

IIA 8.16 Tatum VL 2004 Toxicity, transport, and fate of forest herbicides. 1 Wildlife Society Bulletin 32 (4):1042-1048

IIA 8.16 Tatum VL, Borton DL, 2011 Acute toxicity of commonly used forestry 1 Streblow WR, Louch J, herbicide mixtures to Ceriodaphnia dubia and Shepard JP Pimephales promelas. Environmental Toxicology:n/a-n/a. DOI: 10.1002/tox.20686.

IIA 8.16 Tejada M 2009 Evolution of soil biological properties after addition 2 of glyphosate, diflufenican and glyphosate plus diflufenican herbicides. Chemosphere 76 (3):365- 373. DOI 10.1016/j.chemosphere.2009.03.040.

Page 185 of 192

- 186 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Terech-Majewska E, 2003 The influence of herbicide Roundup on 1 Siwicki AK, Szweda W immunocompetent cells of carp (Cyprinus carpio) and European sheatfish (Silurus glanis). Acta Scientiarum Polonorum - Pis- caria 2 (1):269-278

IIA 8.16 Thomas WE, Burke IC, 2005 Yield and physiological response of nontransgenic 1 Robinson BL, Pline- cotton to simulated glyphosate drift. Weed Technology Srnic WA, Edmisten KL, 19 (1):35-42 Wells R, Wilcut JW

IIA 8.16 Thomas WE, Pline- 2004 Glyphosate negatively affects pollen viability but not 1 Srnic WA, Thomas JF, pollination and seed set in glyphosate-resistant corn. Edmisten KL, Wells R, Weed Science 52 (5):725-734 Wilcut JW

IIA 8.16 Thompson D, Chartrand 2010 Integrating advanced technologies for optimization of 1 D, Staznik B, Leach J, aerial herbicide applications. New Forests 40 (1):45- Hodgins P 66. DOI 10.1007/s11056-009-9181-4.

IIA 8.16 Thompson DG, Woj- 2004 Chemical and biomonitoring to assess potential acute 2 taszek BF, Staznik B, effects of Vision (R) herbicide on native amphibian Chartrand DT, Ste- larvae in forest wetlands. Environmental Toxicology phenson GR and Chemistry 23 (4):843-849

IIA 8.16 Tierney KB, Ross PS, 2006 Changes in juvenile coho salmon electro- 3 K Jarrard HE, Delaney olfactogram during and after short-term exposure to KR, Kennedy CJ current-use pesticides. Environ Toxicol Chem 25 (10):2809-17

IIA 8.16 Tierney KB, Sekela MA, 2011 Evidence for behavioral preference toward 1 Cobbler CE, Xhabija B, environmental concentrations of urban-use Gledhill M, herbicides in a model adult fish. Environ- mental Ananvoranich S, Toxicology and Chemistry 30 (9):2046-2054. DOI: Zielinski BS 10.1002/etc.588.

IIA 8.16 Tierney KB, Singh CR, 2007 Relating olfactory neurotoxicity to altered 1 Ross PS, Kennedy CJ olfactory-mediated behaviors in rainbow trout exposed to three currently-used pesticides. Aquat Toxicol 81 (1):55-64. DOI: 10.1016/j.aquatox.2006.11.006.

IIA 8.16 Tsui MT, Chu LM 2004 Comparative toxicity of glyphosate-based herbicides: 1 aqueous and sediment porewater exposures. Arch Environ Contam Toxicol 46 (3):316-23

IIA 8.16 Tsui MT, Chu LM 2003 Aquatic toxicity of glyphosate-based formulations: 2 comparison between different organisms and the effects of environmental factors. Chemosphere 52 (7):1189-97. DOI: 10.1016/S0045-6535(03)00306-0.

IIA 8.16 Tsui MTK, Wang 2005 Influence of glyphosate and its formulation 1 Also listed WX, Chu LM (Roundup (R)) on the toxicity and bioavailability of under metals to Ceriodaphnia dubia. Environmental IIA 7.13 Pollution 138 (1):59- 68. DOI 10.1016/j.envpol.2005.02.018.

Page 186 of 192

- 187 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Tsumanuma GM, Soares 2010 Effect of herbicides and fungicides on progress 1 AR, Fancelli AL, curves and damage quantification caused by Rodrigues MAT, soybean rust. Ciencia Rural 40 (7):1485-1491. doi: Begliomini E 10.1590/s0103- 84782010005000123.

IIA 8.16 Tuffi Santos LD, de 2007 Growth and Concentration of Nutrients in the Aerial 1 Siqueira CH, de Barros Tissue of Eucalypt under glyphosate drift effect. Cerne NF, Ferreira FA, 13 (4):347-352 Ferreira LR, Machado AFL

IIA 8.16 Tuffi Santos LD, 2005 Leaf Growth and Morphoanatomy of Eucalypt 1 Ferreira FA, Meira under the Effect of Glyphosate Drift. Planta RMSA, Barros NF, Daninha, Viçosa-MG 23 (1):133-142 Ferreira LRE, Machado AFL

IIA 8.16 Tuffi Santos LD, Graca 2011 Glyphosate reduces urediniospore development and 1 RN, Alfenas AC, Ferreira Puccinia psidii disease severity on Eucalyptus FA, Melo CAD, Machado grandis. Pest management science 67 (7):876-880. MS doi: 10.1002/ps.2130.

IIA 8.16 Tuffi Santos LD, Neves 2007 Glyphosate on Eucalyptus Resistance to Rust 1 Graca R, Alfenas AC, (Puccinia psidii). Planta Daninha 25 (1):139-147 Ferreira FA, Ferreira LR, Oda S

IIA 8.16 Tuffi Santos LD, Wagner 2006 Herbicide Drift Simulation and Effect of Fungicide 1 Júnior A, Silva JOC, Planta Daninha, Viçosa-MG 24 (3):505-512 Pimentel LD, Santos CEM, Bruckner CHE, Ferreira FA

IIA 8.16 Turgut C, Fomin A 2002 Sensitivity of the rooted macrophyte Myriophyllum 3 K aquaticum (Vell.) Verdcourt to seventeen pesticides determined on the basis of EC50. Bulletin of Environmental Contamination and Toxicology 69 (4):601- 608. DOI 10.1007/s00128-002-0103-9.

IIA 8.16 Turkington TK, Orr 2001 The influence of Roundup (R) on in vitro growth and 1 DD, Xi K sporulation of Rhynchosporium secalis and Pyrenophora teres. Canadian Journal of Plant Pathology-Revue Canadien- ne De Phytopathologie 23 (3):307-311

IIA 8.16 Unver T, Bakar M, 2010 Genome-wide profiling and analysis of Festuca 1 Shearman RC, Budak H arundinacea miRNAs and transcriptomes in response to foliar glyphosate application. Molecular Genetics and Genomics 283 (4):397-413. DOI 10.1007/s00438-010-0526-7.

IIA 8.16 Usenko OM, 2010 Influence of Phosphorus Bearing Herbicides on the 1 Manturova OV, Functional Activity of Algae. Hydro- biological Sakevich AI Journal 46 (3):73-85. doi: 10.1615/HydrobJ.v46.i3.60.

Page 187 of 192

- 188 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Vera MS, Lagomar- sino 2010 New evidences of Roundup (glyphosate formulation) 3 K L, Sylvester M, Perez GL, impact on the periphyton community and the water Rodriguez P, Mugni H, quality of freshwater ecosystems. Ecotoxicology 19 Sinistro R, Ferraro M, (4):710-21. DOI: 10.1007/s10646-009-0446- Bonet- to C, Zagarese H, 7. Pizarro H

IIA 8.16 Verrell P, Van 2004 As the worm turns: Eisenia fetida avoids soil 2 Buskirk E contaminated by a glyphosate-based herbicide. Bulletin of Environmental Con- tamination and Toxicology 72 (2):219-224. DOI 10.1007/s00128- 003-9134-0.

IIA 8.16 Wagner JA, Tuffi Santos 2008 Drift simulation of glyphosate commercial 1 LD, Santos CEM, Silva formulations on yellow passion fruit growth. Planta JOC, Pimentel LD, Daninha 26 (3):677-683 Bruck- ner CH, Ferreira FA

IIA 8.16 Wagner R, Kogan M, 2003 Phytotoxic activity of root absorbed glyphosate in 1 Also listed Parada AM corn seedlings (Zea mays L.). Weed Biology and under Management 3:228-232 IIA 6.10

IIA 8.16 Wang N, Besser JM, 2005 Influence of sediment on the fate and toxicity of a 1 Also listed Buckler DR, Honegger polyethoxylated tallowamine surfactant system under JL, Ingersoll CG, (MON 0818) in aquatic microcosms. Chemosphere IIA 7.13 Johnson BT, Kurtzweil 59 (4):545-551. DOI ML, 10.1016/j.chemosphere.2004.12.009. MacGregor J, McKee

IIA 8.16 Wang Y, Zhou D, Sun 2006 Effects of glyphosate and Cd interaction on the 2 T R, Hao X activities of several soil enzymes. Asian Journal of Ecotoxicology 1 (1):58-63 IIA 8.16 Weaver MA, Krutz LJ, 2007 Effects of glyphosate on soil microbial 1 Also listed Zablotowicz RM, Reddy communities and its Mississippi soil. Pest under KN Management Science 63 (4):388-393. Doi IIA 7.13 10.1002/Ps.1351.

IIA 8.16 Weidenhamer JD, 2010 Direct and Indirect Effects of Invasive Plants on Soil 1 Callaway RM Chemistry and Ecosystem Function. Journal of Chemical Ecology 36 (1):59-69. DOI 10.1007/s10886- 009-9735-0.

IIA 8.16 White AL, Boutin C 2007 Herbicidal effects on nontarget vegetation: 1 Investigating the limitations of current pesticide registration guidelines. Environ- mental Toxicology and Chemistry 26 (12):2634-2643

IIA 8.16 Wibawa W, Bin 2009 Residual Phytotoxicity Effects of Paraquat, 1 Mohamad R, Bin Puteh Glyphosate and Glufosinate-Ammonium Herbicides in A, Omar D, Juraimi AS, Soils from Field-Treated Plots. International Journal of Abdul- lah SA Agriculture and Biology 11 (2):214-216

IIA 8.16 Wibawa W, Ma- 2010 Comparative impact of a single application of 1 hammad RB, Omar D, selected broad spectrum herbicides on ecological Cain NM, Puteh AB, components of oil palm plantation. African Journal Awang Y of Agricultural Research 5 (16):2097-2102

Page 188 of 192

- 189 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Widenfalk A, Bertilsson 2008 Effects of pesticides on community composition 2 S, Sundh I, Goedkoop and activity of sediment microbes - responses at W various levels of microbial community organization. Envi- ronmental Pollution 152 (3):576-584. DOI 10.1016/j.envpol.2007.07.003.

IIA 8.16 Williams BK, Sem- 2010 Larval Responses of Three Midwestern Anurans to 3 K litsch RD Chronic, Low-Dose Exposures of Four Herbicides. Arch Environ Contam Toxicol 58:819-827. DOI: 10.1007/s00244- 009-9390-z.

IIA 8.16 Wojtaszek BF, Staz- nik 2004 Effects of Vision (R) herbicide on mortality, 2 B, Chartrand DT, avoidance response, and growth of amphibian larvae Stephenson GR, in two forest wetlands. Environmental Toxicology and Thompson DG Chemistry 23 (4):832-842

IIA 8.16 Wrinn KM, Evans 2012 Predator cues and an herbicide affect activity and 2 SC, Rypstra AL emigration in an agrobiont wolf spider. Chemosphere. doi: 10.1016/j.chemosphere.2011.12.030.

IIA 8.16 Xi YL, Feng LK 2004 Effects of thiophanate-methyl and glyphosate on 1 asexual and sexual reproduction in the rotifer Brachionus calyciflorus Pallas. Bulletin of Environmen- tal Contamination and Toxicology 73 (4):644-651. DOI 10.1007/s00128-004- 0475-0.

IIA 8.16 Xiang WS, Wang 2005 Expression of a wheat cytochrome P450 2 XJ, Ren TR, Ju XL monooxygenase in yeast and its inhibition by glyphosate. Pest Management Science 61 (4):402-406. Doi 10.1002/Ps.969.

IIA 8.16 Xiao YH, Zhu SQ, Li 2007 Influences of the herbicide glyphosate- 1 XH, Jiang P isopropylammonium solution on heart activities of Bufo gargarizans. Acta Zoologi- ca Sinica 53 (4) : 668-673. 53 (4):668-673

IIA 8.16 Xie LT, Thrippleton K, 2005 Evaluation of estrogenic activities of aquatic 1 Also listed Irwin MA, Sieme- ring herbicides and surfactants using an rainbow trout under GS, Mekebri A, Crane D, vitellogenin assay. Toxicological Sciences 87 (2):391- IIA 5.10 Berry K, Schlenk D 398. DOI 10.1093/toxsci/kfi249.

IIA 8.16 Xu Y, Liu Q, Hu Z, Shen 2010 Acute Toxicity of Ten Pesticides to Larval Red 1 H, Cao J, Tong L Swamp Crayfish Procambarus clarkii. Asian Journal of Ecotoxicology (Shengtai Duli Xuebao) 5 (1):50- 56

IIA 8.16 Yamashita OM, 2006 Simulated drift of glyphosate in cotton crop: dose 1 Guimaraes SC effect, cultivation and development levels. . Planta Daninha 24 (4):821-826 IIA 8.16 Yamashita OM, 2006 Quality of Cotton Seeds from Plants Submitted to 1 Guimarães SC Reduced Rates of Glyphosate. Planta Daninha Viçosa-MG 24 (2):352-358 IIA 8.16 Yang XY, Harrison 2002 Soybean (Glycine max) response to glyphosate and 1 SK, Riedel RM soybean cyst nematode (Heterodera glycines). Weed Technology 16 (2):332-339

Page 189 of 192

- 190 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

/ point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Yasmin S, D'Souza 2007 Effect of pesticides on the reproductive output of 1 D Eisenia fetida. Bull Environ Con- tam Toxicol 79 (5):529-32. DOI: 10.1007/s00128-007-9269-5.

IIA 8.16 Yates B, Rogers W 2011 Atrazine selects for ichthyotoxic 1 Prymnesium parvum, a possible explanation for golden algae blooms in lakes of Texas, USA. Ecotoxico- logy 20 (8):2003-2010. DOI: 10.1007/s10646-011-0742-x.

IIA 8.16 You W, Chen X, 2010 Toxicity Evaluation of Sixteen Herbicides to Bombyx 1 Song M, Wang C mori. Asian Journal of Ecotoxicology (Shengtai Duli Xuebao) 5 (1):91-94

IIA 8.16 Yuan J, Liu S, Wang 2011 Optimization of microplate toxicity analysis method 1 LJ, Shao Y based on Chlorella pyrenoidose. Research of Environmental Sciences 24 (5):553-558

IIA 8.16 Yupsanis T, Moustakas 2010 Paraquat and roundup effects on nucleases activities 1 M, Symeonidis L, Patras of alfalfa seedlings and alfalfa nucleases activities on A, Christou A, Mantragou paraquat-treated and roundup-treated nucleic acids. C, Yupsani A, Frangopol Acta Physio- logiae Plantarum 32 (1):11-17. DOI P 10.1007/s11738-009-0368-2.

IIA 8.16 Zabaloy MC, Gar- land 2008 An integrated approach, to evaluate the impacts of 1 JL, Gomez MA the herbicides glyphosate, 2,4-D and metsulfuron- methyl on soil microbial communities in the Pampas region, Argentina. Applied Soil Ecology 40 (1):1- 12. DOI 10.1016/j.apsoil.2008.02.004.

IIA 8.16 Zabaloy MC, Gomez 2008 Microbial respiration in soils of the 1 MA Argentine Pampas after metsulfuron methyl, 2,4-D, and glyphosate treatments. Commu- nications in Soil Science and Plant Analysis 39 (3-4):370-385. Doi 10.1080/00103620701826506.

IIA 8.16 Zabaloy MC, Zanini GP, 2011 Herbicides in the Soil Environment: Linkage Between 1 Also listed Bianchinotti V, Gomez Bioavailability and Microbial Ecology. In Herbicides, under MA, Garland JL Theory and Applications, edited by S. Soloneski and IIA 7.13 M. L. Larramendy. Croatia. InTech. pp 161- 192.

IIA 8.16 Zablotowicz RM, 2007 Nitrogenase activity, nitrogen content, and yield 1 K Reddy KN responses to glyphosate in glyphosate- resistant soybean. Crop Protection 26 (3):370-376. DOI 10.1016/j.cropro.2005.05.013.

IIA 8.16 Zhang L, Duan S, Sun 2010 Hormesis effect of organophosphorus pesticide 1 K, Qian X Glyphosate-isopropylammonium on Phaeocystis globosa. Ecology and Envi- ronmental Sciences (China) 19 (1):51-56

Page 190 of 192

- 191 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title

point/ Citation n o reference number Category Evaluation Translati

IIA 8.16 Zhang Y-H, Liu S-S, Liu 2010 Evaluation of the combined toxicity of 15 pesticides 1 H-L, Liu Z-Z by uniform design. Pest Manage- ment Science 66 (8):879-887. DOI: 10.1002/ps.1957.

IIA 8.16 Zhang Z, Wang JT, Tan 2010 Stimulation Effect of Glyphosate on Chaetoceros 1 LJ curvisetus and Dunallelia salina. Asian Journal of Ecotoxicology 5 (5):685-691

IIA 8.16 Zhidenko AA, Kova- 2007 The influence of Roundup on the dynamics of 1 lenko YM histological changes in organs of carps. Hydrobiological Journal 43 (2):93-99 IIA 8.16 Zhydenko AA 2008 Dynamics of the juvenile carps' hematological 1 parameters under the impact of herbicides. Hydrobiological Journal 44 (5):73-80. doi: 10.1615/HydrobJ.v44.i5.80.

IIA 8.16 Zilli JE, Botelho GR, 2008 Effect of glyphosate and imazaquin on the soybean 1 Neves MCP, Rumja- nek rhizoplane bacterial community and microbiological NG soil characteristics. Revista Brasileira De Ciencia Do Solo 32 (2):633- 642

IIA 8.16 Zilli JE, Smiderle OJ, 2007 Microbial population in soil cultivated with soybean 1 Neves MCP and treated with different herbicides in cerrado area of Roraima. Acta Amaz. 37 (2):201-212

Table 3. Supporting publications and documents Annex Author(s) Year Title point/ Citation reference number

IIA 8.16 Carr, K.H. and Bleeke, M.S. 2012 Process Description for Identification, Review, and Also listed Categorization of Scientific Literature Concerning under Glyphosate and AMPA Side-Effects on Health, the IIA 5.10, Environment, and Non-Target Species IIA 6.10, IIA 7.13 IIA 8.16 Giesy JP, Dobson S, Solomon 2000 Ecotoxicological Risk Assessment for Roundup KR Herbicide. Reviews of Environmental Contamination and Toxicology 167: 35-120 IIA 8.16 Hecker M, Hollert H, Cooper R, 2011 The OECD validation program of the H295R Also listed Vinggaard AM, Akahori Y, Murphy steroidogenesis assay: Phase 3. Final inter- laboratory under M, Nellemann C, Higley E, Newsted validation study. Environ Sci Pollut Res Int. 18(3):503-15. IIA 5.10 J, Laskey J, Buckalew A, Grund S, Maletz S, Giesy J, Timm G.

IIA 8.16 Klimisch H.J., Andreae M., 1997 A systematic approach for evaluating the quality Also listed Tillmann U. of experimental toxicological and ecotoxicological data. under Regulatory Toxicology and Pharmacology IIA 5.10, 25 (1):1-5 IIA 6.10, IIA 7.13

Page 191 of 192

- 192 - Glyphosate –List of tests and studies Ecotoxicology Annex Author(s) Year Title point/ Citation reference number

IIA 8.16 Kojima, H., E. Katsura, S. Ta- 2004 Screening for estrogen and androgen receptor activities Also listed keuchi, K. Niiyama and K. Ko- in 200 pesticides by in vitro reporter gene assays using under bayashi. Chinese hamster ovary cells. Environmental Health IIA 5.10 Perspectives 112: 524-531

IIA 8.16 Petit F, LeGoff P, Cravedi J-P, 1997 Two complementary bioassays for screening the Valotaire Y, Pakdel F. estrogenic potency of xenobiotics: recombinant yeast for trout estrogen receptor and trout hepatocyte cultures. J. Molecular Endocrinology. 19: 321-335.

Page 192 of 192