Supplementary Table 3. Differentially expressed involved in activated pathways in

embryos (Day 7.5) collected from cows fed a diet supplemented with either flax (FLX) vs.

sunflower (SUN) seed. Red and green symbols indicate up- and down-regulated genes,

respectively.

Network Top diseases and functions Molecules in network 1 Amino Acid Metabolism, ABCG2, Akt, BTG2, CALB1, CD3, CLDN4, Post-Translational CLDN23, COL12A1, COL9A2, CXCL14, DSC2, Modification, Small EPS8L1, estrogen receptor, F Actin, GCSH, GLDC, Molecule Biochemistry Gm-csf, histone deacetylase, Histone h4, HMGN1, Hsp27, ID2, Mek, MGLL, N-cor, PFKL, PLAC8, Ppp2c, PRSS8, STAT5a/b, TACC2, Tnf (family), TRIM63, ULBP1

2 DNA Replication, ABHD14B, ACOT1, AIM1L, APMAP, DARS2, Recombination, and DCAF13, EMG1, ETNPPL, FAM127A, FSIP2, Repair, Nucleic Acid GIMAP4, HEBP2, KBTBD6, KRT2, LIPH, MFF, Metabolism, RNA Post- MPV17L2, NEDD8, NIPSNAP3A, NSUN5, Transcriptional NUCB1, NUDT19, PSAT1, QTRT1, QTRTD1, Modification RNPEP, SCFD2, SH3BGRL, SLC34A2, STAT5B, TMEM45B, UBC, URGCP, ZDHHC2, ZYG11B

3 Cellular Growth and ALDH3A2, Alpha catenin, Calcineurin (s), Proliferation, Cell Death CALML5, caspase, Cg, EDN3, ENPP3, FSH, and Survival, GADD45B, GFPT2,GOT, Hdac, IFI30, Ifn, IL12 Gastrointestinal Disease (complex), IL1RN, Immunoglobulin, KIAA0930, KRT19, LDL, Lh, MEF2, NFkB (complex), Nos, PTGS2, SAA, SFN, Sod, SRXN1, TBX3, TCF, Tgf beta, TIMP1, XDH

4 Cell Morphology, ANXA1, ANXA4, B2M, BCR (complex), calpain, Hematological System CAMK2N2, CD8, CD8B, Cyclin A, EFNA1, Development and ERK1/2, FOLH1, Ige, Igm, Laminin, LGALS3, Function, Cell-mediated MHC Class I (complex), Mucin, Nfat (family), Immune Response NID1, Pak, PI3K (family), PLA2, PLA2R1, PLCL2, PTPN5, Rac, Rap1, SCIN, Sos, SYK/ZAP, TDGF1, TRPM6, TSH, ZAP70

5 Cellular Development, A2ML1, Acot1, AGPAT1, APOBEC1, AQP11, Lipid Metabolism, Small BCL9, beta-estradiol, C8orf4, CCBL1, cholesterol, Molecule Biochemistry CHPT1, ELAVL1, FAM107A, FAM134C, GFM1, GIPC2, HCST, HSD17B11, IFI30, IFNG, LTA4H, MS4A8, PDCD7, PPM1K, PTGDR, RT1-EC2, RTP4, SCIMP, SMPDL3A, SUSD2, TGFB1, TMEM50B, WWOX, ZNF638, ZNF280B

6 Endocrine System Ap1, AS3MT, AUTS2, Collagen type IV, Development and Collagen(s), CSRP2, ERK, FOS, GNRH, GST, Function, Cell Death and GSTO1, IL1, Interferon alpha, Mapk, MGAT4A, Survival, Neurological MGST2, Mmp, NADPH oxidase, NMDA Receptor, Disease NR3C1, P38 MAPK, p85 (pik3r), Pdgf (complex), PDGF BB, Pka, Pkc(s), PLC, PSAT1, Ras, SCARB2, SLC7A7, TCR, Tlr, , Vegf

7 Inflammatory Response, ANXA2, ANXA3, APP, CDH24, CLEC2B, DPYS, Cell-To-Cell Signaling and GC, GRB2, Hmgn2 (includes others), IFI35, KRT2, Interaction, Nervous LY6G6C, MDK, NCL, neuroprotectin D1, NFAM1, System Development and NMT2, ORC6, OSM, Pde4d, PDK3, PLLP, Function PQLC3, PTGDR, RNASEL, ROBO4, SERPING1, SLC23A1, TDO2, TMC4, TMCO4, TMEM245, TNF, TP53, TSPAN12

8 Cell Morphology, 26s Proteasome, Actin, ALAD, Atf, CCDC71, Inflammatory Response, Endothelin, FAM3B, FBXO45, FFAR4, FOXRED2, Cell Cycle Gamma tubulin, GPN3, Gsk3, H2-L, Histone h3, HSD17B11, IgG, IKZF1, IL12 (family), Insulin, Jnk, LARP1B, MAP1LC3A, MTCH2, NME7, PADI3, PI3K (complex), RFTN1, RNA polymerase II, SLC25A12, TNFAIP8L2, TPI1, UBD, Ubiquitin, VPS36

9 Cell Death and Survival, ADM, ANP32A, AQP1, ATF3, BLM, CASP3, Cellular Growth and CASP10, CYR61, DNMT3B, EIF2AK3, ELK1, Proliferation, Cellular EMILIN2, EPHA7, GCG, HBEGF, HFE, HK2, Development KLF4, LMNB1, NDRG1, NFATC3, NGFR, NUPR1, OSBPL6, PEA15, PIM1, PTGES3, PTMA, RAD51, SLC2A1, TFAP2A, TNFRSF10A, TNFRSF10B, UNC5B, XRCC2

10 Developmental Disorder, GPR3, TMEM5 Hereditary Disorder, Metabolic Disease