Low Molecular Weight Heparin Versus Acenocoumarol in the Secondary Prophylaxis of Deep Vein Thrombosis
Thromb Haemost 1999; 81: 26–31 © 1999 Schattauer Verlag, Stuttgart Low Molecular Weight Heparin versus Acenocoumarol in the Secondary Prophylaxis of Deep Vein Thrombosis S. Lopaciuk, H. Bielska-Falda1, W. Noszczyk1, M. Bielawiec 2, W. Witkiewicz 3, S. Filipecki 4, J. Michalak 5, L. Ciesielski 6, Z. Mackiewicz 7, E. Czestochowska 8, K. Zawilska 9, A. Cencora 10, among others* From the Institute of Hematology and Blood Transfusion, Warsaw, 1st 1Department of Surgery, Medical School, Warsaw, 2Department of Hematology, Medical School, Bialystok, 3Department of Vascular Surgery, District General Hospital, Wroclaw, 4Department of Internal Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, 5Department of Vascular Surgery, Medical School, Lublin, 1st 6Department of Surgery, Medical School, Lodz, 7Department of Vascular Surgery, Medical School, Bydgoszcz, 3rd 8Department of Internal Medicine, Medical School, Gdansk, 9Department of Hematology, Medical School, Poznan, and 10Department of Vascular Surgery, District General Hospital, Krakow, Poland Summary oral anticoagulant for at least 3 months (secondary prophylaxis). Al- though long-term anticoagulation with coumarin drugs, the most popu- The aim of this study was to determine the efficacy and safety of lar of which are warfarin and acenocoumarol, has been repeatedly dem- subcutaneous weight-adjusted dose low molecular weight heparin onstrated effective in the prevention of recurrent venous thromboembo- (LMWH) compared with oral anticoagulant (OA) in the prevention of lism, it suffers from a number of limitations. This treatment requires recurrent venous thromboembolism. In a prospective multicenter trial, strict laboratory control and consequent adjustments of the drug dosage 202 patients with symptomatic proximal deep vein thrombosis (DVT) and carries a substantial risk of bleeding complications (1).
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