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Pressure-Volume Curves of the Respiratory System Pressure-Volume Curves of the Respiratory System R Scott Harris MD Introduction Equation of Motion Static Versus Dynamic Pressure-Volume Curves Static Compliance, Chord Compliance, Specific Compliance, and the Pressure-Volume Curve Measurement Supersyringe Method Constant-Flow Method Multiple-Occlusion Method Physiologic Meaning Lung Versus Chest Wall Supine Posture Hysteresis Alterations in Disease States Obesity Acute Respiratory Distress Syndrome Congestive Heart Failure Emphysema Asthma Interstitial Lung Disease Intra-Abdominal Hypertension Summary The quasi-static pressure-volume (P-V) curve of the respiratory system describes the mechanical behavior of the lungs and chest wall during inflation and deflation. To eliminate resistive and convective acceleration effects, the measurement of volume and pressure must be performed during short periods of apnea or during very slow flow. There are 3 main techniques for acquiring quasi-static P-V curves: the supersyringe method, the constant flow method, and the multiple- occlusion (or ventilator) method. For the information to be interpreted correctly, one must under- stand the interaction between the lungs and the chest wall, the effects of the supine position, and the meaning of hysteresis. The P-V curve has been studied in many disease states, but it has been applied most extensively to patients with acute respiratory distress syndrome, in hopes that it might allow clinicians to customize ventilator settings according to a patient’s individual respiratory mechanics and thus protect the patient from ventilator-induced lung injury. However, lack of standardization of the procedure used to acquire P-V curves, difficulties in measuring absolute lung volume, lack of knowledge regarding how to use the information, and a paucity of data showing a benefit in morbidity and mortality with the use of P-V curves have tempered early enthusiasm regarding the clinical usefulness of the quasi-static P-V curve. Key words: lung mechanics, compli- ance, lung recruitment, pressure-volume curve, mechanical ventilation; acute respiratory distress syn- drome; waveforms. [Respir Care 2005;50(1):78–98. © 2005 Daedalus Enterprises] 78 RESPIRATORY CARE • JANUARY 2005 VOL 50 NO 1 PRESSURE-VOLUME CURVES OF THE RESPIRATORY SYSTEM Introduction such that only the compliance is assessed. Thus, static P-V curves are also called compliance curves. Also evident is In spontaneously breathing subjects the diaphragm and the respiratory muscle contribution to pressure. If a subject chest wall together form a mechanical pump that moves is not sufficiently sedated (or paralyzed), the measured air in and out of the lungs to exchange oxygen and carbon P-V curve may not be representative of the lung compli- dioxide to and from the blood. When the respiratory sys- ance properties alone and may include effects of the re- tem fails and mechanical ventilation is necessary, the re- spiratory muscles. spiratory system’s mechanical behavior can change in char- acteristic ways that can be assessed by the mechanical Static Versus Dynamic Pressure-Volume Curves ventilator or with simple equipment available in respira- tory care departments. The quasi-static pressure-volume Whenever one measures pressure when airflow has (P-V) relationship is one aspect of mechanical behavior stopped, there is always a continual change in pressure— that has been used to gain information about the way the lowering in an exponential fashion. Because we must al- lungs deform during breathing in health and disease. low the subject to breathe, the measurement must be in- It has long been hoped that with mechanically ventilated terrupted after a few seconds. Therefore, the system never patients the P-V curve would allow the clinician to diag- reaches truly static conditions, so we obtain what has been nose lung disease, customize ventilator settings, follow the called a “quasi-static” P-V curve. This means that the course of disease, and make prognoses. Surprisingly, de- resultant curve depends somewhat on how long the clini- spite over a half-century of research on P-V curves, we cian waits for static conditions. It is possible to use a slow still have a limited understanding of the meaning of the flow rate to approximate static conditions, but the flow P-V relationship. So, though some of those goals have rate must be Ͻ 9 L/min to largely eliminate the pressure been realized, much research still needs to be done before change from resistive elements of the respiratory system.1,2 P-V curves can be widely used clinically. The confusing term “dynamic compliance” has been used to mean various things, but it originally referred to Equation of Motion compliance calculated during a tidal breath at the points of zero flow on the dynamic P-V loop. Some investigators The equation of motion describes the pressure change at have made arguments that perhaps P-V measurements the airway opening during breathing. The equation as- should be made during breathing rather than in quasi-static sumes one degree of freedom, meaning that the lung ex- conditions, since that might be more representative of the pands equally in all directions (isotropic expansion). It is mechanical behavior that the lung experiences during written as: breathing. Ranieri et al3 used the shape of the inspiratory pressure-time curve during constant flow to calculate a V “stress index,” which, they argue, can detect overdisten- ϭ ϩ ˙ ϩ ¨ Ϫ PAO C VR VI Pmus (1) tion or recruitment. Lichtwarck-Aschoff et al4 advocate using the “slice method” to estimate static compliance in which PAO is the pressure at the airway opening (mouth from a dynamic P-V loop, using a linear resistance-com- 5 or endotracheal tube), Pmus is the pressure generated by the pliance model. Karason et al developed a method to cal- respiratory muscles, V is lung volume, C is respiratory- culate the alveolar pressure during dynamic/therapeutic system compliance, V˙ is gas flow, R is airway resistance, conditions, which they call the “dynostatic pressure.” They V¨ is convective gas acceleration, and I is impedance. What argue that this method has the advantage that it provides a is evident from that equation is that a static P-V curve breath-by-breath analysis of the P-V relationship, without eliminates the resistive and impedance effects on pressure, requiring ventilator disconnects. Adams et al6 studied the effect of increasing constant flows on the shape of the inspiratory P-V loop. They mea- R Scott Harris MD is affiliated with the Pulmonary and Critical Care sured a quasi-static P-V curve, using the supersyringe tech- Unit, Department of Medicine, Massachusetts General Hospital, Harvard nique, and compared it with inspiratory P-V curves mea- Medical School, Boston, Massachusetts. sured with 10, 30, and 50 L/min constant inspiratory flows in dogs with oleic-acid-induced lung injury. They found R Scott Harris MD presented a version of this article at the 34th RESPI- RATORY CARE Journal Conference, Applied Respiratory Physiology: Use that the curve consistently shifted to the right at all in- of Ventilator Waveforms and Mechanics in the Management of Critically spiratory flows tested (Fig. 1). They also found that during Ill Patients, held April 16–19, 2004, in Cancu´n, Mexico. the measurement of the dynamic P-V curves there was Correspondence: R Scott Harris MD, Pulmonary and Critical Care Unit, increased volume at the beginning of the dynamic inspi- Bulfinch 148, Massachusetts General Hospital, 55 Fruit Street, Boston rations while on positive end-expiratory pressure (PEEP), MA 02114. E-mail: [email protected]. which, they concluded, was recruitment from tidal venti- RESPIRATORY CARE • JANUARY 2005 VOL 50 NO 179 PRESSURE-VOLUME CURVES OF THE RESPIRATORY SYSTEM Fig. 1. Comparison of static and dynamic pressure-volume (P-V) Fig. 2. Effect of PEEP on static compliance (C ). In this example, loops. The thick solid line is the quasi-static P-V loop acquired stat if C is measured with a PEEP of zero (⌬V0/⌬P0) on one day and with the supersyringe method. The thin solid, dotted, and dashed stat then a PEEP of 15 cm H O(⌬V15/⌬P15) the next day, one could lines are dynamic P-V loops acquired with inspiratory flow rates of 2 50, 30, and 10 L/min, respectively. P-V loops were collected at 3 erroneously interpret that as an improvement in the patient’s lung different PEEP levels. Note the rightward shift of the P-V curve disease (increased compliance). However, this change in compli- with increasing flow rate, which represents increased pressure ance is simply a change in the position of the volume excursion on generated from airway resistance. Note also the increased volume the same pressure-volume curve. at each PEEP level at the beginning of the curve, representing tidal recruitment. (From Reference 6, with permission.) pliance.” Specific compliance is compliance that is nor- malized by a lung volume, usually total lung capacity (TLC) or functional residual capacity (FRC). Thus, given lation independent of PEEP. From that study it is clear that the same volume excursion, a child will have lower chord measuring P-V curves with tidal ventilation at high flow compliance than an adult, but they will have the same (Ն 10 L/min) still leaves a large pressure change from specific compliance. Specific compliance is often used to resistive components, and, furthermore, that there is a better assess the intrinsic elastic properties of the lung, by PEEP-independent volume-recruitment effect. This last eliminating the effects of variations in lung size. point will be discussed below, in the section that describes the multiple-occlusion method for measuring P-V curves. Measurement Static Compliance, Chord Compliance, Specific Compliance, and the Pressure-Volume Curve There are 3 main techniques for constructing a quasi- static P-V curve: the supersyringe method, the constant- flow method, and the multiple-occlusion method.
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