Alopecia Areata
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NAIL DISEASES and NAIL HEALTH Your Nails Can Tell You a Lot About Your Health
Dermatology Patient Education NAIL DISEASES AND NAIL HEALTH Your nails can tell you a lot about your health. Nail diseases and warning signs of other health problems appear on the nails. Your nails also reveal whether you are taking good care them. Good nail care is important because it can help prevent many common nail problems. NAIL DISEASES The skin around our nails and the tissue beneath are susceptible to many diseases. If you see any of the following, promptly see a dermatologist. Early diagnosis and proper treatment offer the best outcome. If allowed to progress, nail disease can be challenging to treat. Melanoma under the nail • Dark spot or streak Melanoma (skin cancer): Nail streaks are common in people of color. While many nail streaks are harmless, it is important to know that about 30% to 40% of melanomas that occur in people of color develop under a nail. While melanoma under the nail is more common in people of color, anyone can get melanoma under a nail. If your nail has a dark streak or spot and you do not remember injuring the nail, promptly see a dermatologist. When caught early, melanoma can be cured. • Growth Skin cancer: Many different types of skin cancer, including melanoma and Squamous cell carcinoma, can form under or around a nail. If you see a growth under or around your nail, promptly see a dermatologist. Your dermatologist can tell you whether the growth should be removed. Wart: A growth on the skin surrounding a nail is often a wart. Warts are common on the hands and feet. -
A RARE PRESENTATION of INGROWN TOE NAIL *Alagar Samy R
CIBTech Journal of Surgery ISSN: 2319-3875 (Online) An Open Access, Online International Journal Available at http://www.cibtech.org/cjs.htm 2015 Vol. 4 (1) January-April, pp.24-27/Samy Case Report A RARE PRESENTATION OF INGROWN TOE NAIL *Alagar Samy R. ESIC Medical College and Hospital, Coimbatore, Tamilnadu, India *Author for Correspondence ABSTRACT Onychocryptosis or ingrown toenail is a very common pathology of the toenail unit, chiefly affecting adolescents and young adults. The ingrown toenail is responsible for disabling complaints like pain and difficulty in walking. It is associated with significant morbidity, hampering the quality of life as it interferes with sporting activities, school, or work. It principally occurs in the hallux. It is ascribed to poor trimming of the nails in combination with local pressure due to ill-fitting footwear, hyperhidrosis, poor foot hygiene and nail abnormalities. Pain, swelling and discharge are the main clinical features. Four stages of the condition have been described. Diagnosis is usually evident, but it should be differentiated from subungual exostosis and tumors of the nail bed (James et al., 2006). I report a case of in grown toe nail involving right great toe with a swelling in the same toe with occasional pain. There was no history of trauma or any co morbid illness. Hence the right great toe nail with a swelling excised intoto. The Histopathological examination revealed only chronic inflammation. The post operative period was uneventful and discharged on third post operative period. It is being presented for its rarity. Keywords: Onychocryptosis, Hallux, Ingrown, Avulsion INTRODUCTION Onychocryptosis or ingrown toenail is a very common pathology of the toenail unit, chiefly affecting adolescents and young adults. -
Hair Loss in Infancy
SCIENCE CITATIONINDEXINDEXED MEDICUS INDEX BY (MEDLINE) EXPANDED (ISI) OFFICIAL JOURNAL OF THE SOCIETÀ ITALIANA DI DERMATOLOGIA MEDICA, CHIRURGICA, ESTETICA E DELLE MALATTIE SESSUALMENTE TRASMESSE (SIDeMaST) VOLUME 149 - No. 1 - FEBRUARY 2014 Anno: 2014 Lavoro: 4731-MD Mese: Febraury titolo breve: Hair loss in infancy Volume: 149 primo autore: MORENO-ROMERO No: 1 pagine: 55-78 Rivista: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA Cod Rivista: G ITAL DERMATOL VENEREOL G ITAL DERMATOL VENEREOL 2014;149:55-78 Hair loss in infancy J. A. MORENO-ROMERO 1, R. GRIMALT 2 Hair diseases represent a signifcant portion of cases seen 1Department of Dermatology by pediatric dermatologists although hair has always been Hospital General de Catalunya, Barcelona, Spain a secondary aspect in pediatricians and dermatologists 2Universitat de Barcelona training, on the erroneous basis that there is not much in- Universitat Internacional de Catalunya, Barcelona, Spain formation extractable from it. Dermatologists are in the enviable situation of being able to study many disorders with simple diagnostic techniques. The hair is easily ac- cessible to examination but, paradoxically, this approach is often disregarded by non-dermatologist. This paper has Embryology and normal hair development been written on the purpose of trying to serve in the diag- nostic process of daily practice, and trying to help, for ex- ample, to distinguish between certain acquired and some The full complement of hair follicles is present genetically determined hair diseases. We will focus on all at birth and no new hair follicles develop thereafter. the data that can be obtained from our patients’ hair and Each follicle is capable of producing three different try to help on using the messages given by hair for each types of hair: lanugo, vellus and terminal. -
Nails Develop from Thickened Areas of Epidermis at the Tips of Each Digit Called Nail Fields
Nail Biology: The Nail Apparatus Nail plate Proximal nail fold Nail matrix Nail bed Hyponychium Nail Biology: The Nail Apparatus Lies immediately above the periosteum of the distal phalanx The shape of the distal phalanx determines the shape and transverse curvature of the nail The intimate anatomic relationship between nail and bone accounts for the bone alterations in nail disorders and vice versa Nail Apparatus: Embryology Nail field develops during week 9 from the epidermis of the dorsal tip of the digit Proximal border of the nail field extends downward and proximally into the dermis to create the nail matrix primordium By week 15, the nail matrix is fully developed and starts to produce the nail plate Nails develop from thickened areas of epidermis at the tips of each digit called nail fields. Later these nail fields migrate onto the dorsal surface surrounded laterally and proximally by folds of epidermis called nail folds. Nail Func7on Protect the distal phalanx Enhance tactile discrimination Enhance ability to grasp small objects Scratching and grooming Natural weapon Aesthetic enhancement Pedal biomechanics The Nail Plate Fully keratinized structure produced throughout life Results from maturation and keratinization of the nail matrix epithelium Attachments: Lateral: lateral nail folds Proximal: proximal nail fold (covers 1/3 of the plate) Inferior: nail bed Distal: separates from underlying tissue at the hyponychium The Nail Plate Rectangular and curved in 2 axes Transverse and horizontal Smooth, although -
Nail Involvement in Alopecia Areata
212 CLINICAL REPORT Nail Involvement in Alopecia Areata: A Questionnaire-based Survey on DV Clinical Signs, Impact on Quality of Life and Review of the Literature 1 2 2 1 cta Yvonne B. M. ROEST , Henriët VAN MIDDENDORP , Andrea W. M. EVERS , Peter C. M. VAN DE KERKHOF and Marcel C. PASCH1 1 2 A Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, and Health, Medical and Neuropsychology Unit, Institute of Psychology, Leiden University, Leiden, The Netherlands Alopecia areata (AA) is an immune-mediated disease at any age, but as many as 60% of patients with AA will causing temporary or permanent hair loss. Up to 46% present with their first patch before 20 years of age (4), and of patients with AA also have nail involvement. The prevalence peaks between the 2nd and 4th decades of life (1). aim of this study was to determine the presence, ty- AA is a lymphocyte cell-mediated inflammatory form pes, and clinical implications of nail changes in pa- of hair loss in which a complex interplay between genetic enereologica tients with AA. This questionnaire-based survey eva- factors and underlying autoimmune aetiopathogenesis V luated 256 patients with AA. General demographic is suggested, although the exact aetiological pathway is variables, specific nail changes, nail-related quality of unknown (5). Some studies have shown association with life (QoL), and treatment history and need were evalu- other auto-immune diseases, including asthma, atopic ated. Prevalence of nail involvement in AA was 64.1%. dermatitis, and vitiligo (6). ermato- The specific nail signs reported most frequently were Many patients with AA also have nail involvement, D pitting (29.7%, p = 0.008) and trachyonychia (18.0%). -
NAIL CHANGES in RECENT and OLD LEPROSY PATIENTS José M
NAIL CHANGES IN RECENT AND OLD LEPROSY PATIENTS José M. Ramos,1 Francisco Reyes,2 Isabel Belinchón3 1. Department of Internal Medicine, Hospital General Universitario de Alicante, Alicante, Spain; Associate Professor, Department of Medicine, Miguel Hernández University, Spain; Medical-coordinator, Gambo General Rural Hospital, Ethiopia 2. Medical Director, Gambo General Rural Hospital, Ethiopia 3. Department of Dermatology, Hospital General Universitario de Alicante, Alicante, Spain; Associate Professor, Department of Medicine, Miguel Hernández University, Spain Disclosure: No potential conflict of interest. Received: 27.09.13 Accepted: 21.10.13 Citation: EMJ Dermatol. 2013;1:44-52. ABSTRACT Nails are elements of skin that can often be omitted from the dermatological assessment of leprosy. However, there are common nail conditions that require special management. This article considers nail presentations in leprosy patients. General and specific conditions will be discussed. It also considers the common nail conditions seen in leprosy patients and provides a guide to diagnosis and management. Keywords: Leprosy, nails, neuropathy, multibacillary leprosy, paucibacillary leprosy, acro-osteolysis, bone atrophy, type 2 lepra reaction, anonychia, clofazimine, dapsone. INTRODUCTION Leprosy can cause damage to the nails, generally indirectly. There are few reviews about the Leprosy is a chronic granulomatous infection affectation of the nails due to leprosy. Nails are caused by Mycobacterium leprae, known keratin-based elements of the skin structure that since ancient times and with great historical are often omitted from the dermatological connotations.1 This infection is not fatal but affects assessment of leprosy. However, there are the skin and peripheral nerves. The disease causes common nail conditions that require diagnosis cutaneous lesions, skin lesions, and neuropathy, and management. -
Hair and Nail Disorders
Hair and Nail Disorders E.J. Mayeaux, Jr., M.D., FAAFP Professor of Family Medicine Professor of Obstetrics/Gynecology Louisiana State University Health Sciences Center Shreveport, LA Hair Classification • Terminal (large) hairs – Found on the head and beard – Larger diameters and roots that extend into sub q fat LSUCourtesy Health of SciencesDr. E.J. Mayeaux, Center Jr., – M.D.USA Hair Classification • Vellus hairs are smaller in length and diameter and have less pigment • Intermediate hairs have mixed characteristics CourtesyLSU Health of E.J. Sciences Mayeaux, Jr.,Center M.D. – USA Life cycle of a hair • Hair grows at 0.35 mm/day • Cycle is typically as follows: – Anagen phase (active growth) - 3 years – Catagen (transitional) - 2-3 weeks – Telogen (preshedding or rest) about 3 Mon. • > 85% of hairs of the scalp are in Anagen – Lose 75 – 100 hairs a day • Each hair follicle’s cycle is usually asynchronous with others around it LSU Health Sciences Center – USA Alopecia Definition • Defined as partial or complete loss of hair from where it would normally grow • Can be total, diffuse, patchy, or localized Courtesy of E.J. Mayeaux, Jr., M.D. CourtesyLSU of Healththe Color Sciences Atlas of Family Center Medicine – USA Classification of Alopecia Scarring Nonscarring Neoplastic Medications Nevoid Congenital Injury such as burns Infectious Systemic illnesses Genetic (male pattern) (LE) Toxic (arsenic) Congenital Nutritional Traumatic Endocrine Immunologic PhysiologicLSU Health Sciences Center – USA General Evaluation of Hair Loss • Hx is -
Alopecia Areata – a Literature Review
Review Article Alopecia Areata – A literature Review S Mushtaq 1*, Md. Raihan2, Azad Lone3, Mushtaq M4 1M.D. Scholar, Jamia Hamdard, Hamdard University, New Delhi; 2Assistant Professor, Department of Dermatology, Rama Medical College Delhi; 3Medical Officer, ISM department, Govt. of Jammu and Kashmir; 4Medical Officer, L.D Hospital, Govt. of Jammu and Kashmir. ABSTRACT Alopecia areata (AA) is a disease marked by extreme variability in hair loss, not only at the time of initial onset of hair loss but in the duration, extent and pattern of hair loss during any given episode. This variable and unpredictable nature of spontaneous re-growth and lack of a uniform response to various therapies has made clinical trials in alopecia areata difficult to plan and implement. It is a type of alopecia that affects males and females equally. It occurs in both children and adults. The peak age of occurrence is 20 to 50 years .The most common clinical presentation is asymptomatic shedding of telogen hairs followed by patchy non scarring hair Dermatology loss in association with nail pitting, Beau’s line and nail dystrophy. The disease may progress from this limited – presentation to total loss of all scalp hairs (Alopecia totalis) or all body hair (alopecia universalis) with significant onychodystrophy. Mostly it is characterised by reversible hair loss involving the scalp although others areas of head including eyelashes, eyebrows and beard may also be affected. Although, it is a mostly Section cosmetic problem but it often has devastating effects on quality of life and self-esteem. The paper aims at providing an overview of Alopecia areata. -
A Leukonychia Nail Disease Detection Using Deep Learning Approach
8 III March 2020 International Journal for Research in Applied Science & Engineering Technology (IJRASET) ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.429 Volume 8 Issue III Mar 2020- Available at www.ijraset.com A Leukonychia Nail Disease Detection using Deep Learning Approach Naveen1, Gaurav Rai2, Aquib Hussain3, Amit Kumar4, Rahul Nijhawan5 1, 2, 3, 4Student, COER Roorkee, Uttarakhand, India 5Guide, GEU Dehradun, Uttarakhand, India Abstract: Nail Diseases are some kind of deformities in nails. Detection of Nail Disease (Leukonychia) using modern state-of- the-art technological tools, thereby reducing the dependency on medical experts. It is still challenging to identify the disease in Nails. Leukonychia, is a medical term for white discoloration appearing on nails. The most common cause is injury to the base of the nail where the nail is formed. The common causes that are noticed around the nails are changing the color of nails to dark streaks, white streaks, changes in nail shape, changes in nail thickness, bleeding around nails or change in nail color. This affection of the disease is about 31% in the adult population. Treatment of leukonychia has been reported from treating malnutrition associated with zinc deficiency and other minerals. This paper strives for a deep convolutional neural network to classify Leukonychia disease from images that are provided in the dataset. The skeleton uses (VGG)-16, (VGG)-19 and INCEPTION-V3 for extracting the features. Due to the absence of an active dataset, a new dataset was created for testing the correctness of our debatable framework. This work is tested on our dataset and is measured with other advanced algorithms (Artificial Neural Network, Support Vector Machine, Random Forest, Adaboost, CN2 Rule Induction, K-Nearest Neighbour, Naive Bayes and Logistic Regression) which results in considerable performance in extraction of features. -
Case Report a Case and Review of Congenital Leukonychia Akhilesh S
Volume 22 Number 10 October 2016 Case Report A case and review of congenital leukonychia Akhilesh S Pathipati1 BA, Justin M Ko2 MD MBA and John M Yost3 MD MPH Dermatology Online Journal 22 (10): 6 1 Stanford University School of Medicine, Stanford, CA 2 Stanford University School of Medicine, Department of Dermatology, Stanford, CA 3Stanford University School of Medicine, Department of Dermatology, Nail Disorders Clinic, Stanford, CA Correspondence Akhilesh S Pathipati 291 Campus Drive Stanford, CA 94305 Tel. (916)725-3900; Fax. (650)721-3464; Email: [email protected] Abstract Leukonychia refers to a white discoloration of the nails. Although several conditions may cause white nails, a rare, isolated, congenital form of the disease is hypothesized to stem from disordered keratinization of the nail plate. Herein, we report a case of a 41-year-old woman with congenital leukonychia and review prior cases. Keywords: Leukonychia, Nail disorders, Congenital nail disease Introduction Leukonychia is defined as a white or milky discoloration of the nail plate and has traditionally been subclassified into true and apparent variants. Apparent leukonychia derives from pathological changes in the nail bed (most commonly edema) resulting in tissue pallor visible through the nail plate, whereas true leukonychia stems from structural abnormalities of the nail plate itself owing to disordered keratinization occurring in the nail matrix [1]. In the latter, the white opacity of the nail plate derives from two separate histopathologic features: retained parakeratotic cells containing enlarged keratohyaline granules and disorganized keratin fibrils [2,3]. Both of these abnormalities affect and impede light diffraction through the nail plate, ultimately contributing to the characteristic white discoloration [1]. -
Etiopathogenesis of Alopecia Areata
y & Tran ap sp r la e n h t T a r t i i o a n H Hair : Therapy & Transplantation Bhat, et al., Hair Ther Transplant 2014, 4:2 DOI: 10.4172/2167-0951.1000123 ISSN: 2167-0951 Review Article Open Access Etiopathogenesis of Alopecia Areata Yasmeen J Bhat*, Peerzada Sajad and Iffat Hassan Department of Dermatology, STD & Leprosy, Government Medical College, University of Kashmir, Srinagar, J&K- India *Corresponding author: Yasmeen J Bhat, Department of Dermatology, STD & Leprosy, Government Medical College, Srinagar (J&K), India, Tel: 019-42453114; E- mail: [email protected] Rec date: March 22, 2014; Acc date: April 22, 2014; Pub date: April 28, 2014 Copyright: © 2014 Bhat YJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Alopecia areata (AA) is a recurrent, non-scarring type of hair loss affecting the hair follicles and sometimes the nails. Current evidence indicates that hair follicle inflammation in alopecia areata is caused by a T-cell mediated autoimmune mechanism occurring in genetically predisposed individuals. Environmental factors like infections, diet, vaccination and stress may be responsible for triggering the disease. The association between alopecia areata and other autoimmune diseases suggests that alopecia areata is itself an autoimmune disease. Recently many cytokines have been implicated in the pathogenesis of AA and these are focused upon in this article. Keywords: Alopecia areata; Hair loss; Autoimmune diseases children, and in 50-60% of AA patients the first patch usually develops before 20 years of age. -
A Case of Twenty Nail Dystrophy and Review of Treatment Options Emily Tongdee, BS,* Shahjahan Shareef, BS,** Tracy Favreau, DO,*** Khasha Touloei, DO****
A Case of Twenty Nail Dystrophy and Review of Treatment Options Emily Tongdee, BS,* Shahjahan Shareef, BS,** Tracy Favreau, DO,*** Khasha Touloei, DO**** *Medical student, Florida International University Herbert Wertheim College of Medicine, Miami, FL **Medical student, Nova Southeastern University College of Osteopathic Medicine, Ft. Lauderdale, FL ***Dermatologist, Nova Southeastern University College of Osteopathic Medicine, Ft. Lauderdale, FL ****Dermatology resident, 3rd year, Nova Southeastern University College of Osteopathic Medicine, Ft. Lauderdale, FL Disclosures: None Correspondence: Shahjahan Shareef; [email protected] Abstract Twenty nail dystrophy (TND), also known as trachyonychia, is an abnormality of the proximal nail matrix. It presents as a homogenous roughness, giving the nail a sandpaper-like appearance.1- 3 Idiopathic trachyonychia most commonly presents with spongiotic inflammation with exocytosis of inflammatory cells.1,3-5 This disease has been shown to spontaneously resolve within about five to six years, but that may be too long for some patients, as this nail disorder can be cosmetically disfiguring, further impacting quality of life.6,7 We present a case of idiopathic TND and provide an updated review of the literature and the various treatments that have been utilized to treat the condition. Griseofulvin injections, PUVA, systemic steroids, oral retinoids, cyclosporine A, and nail plate dressings have shown to be highly successful treatment options. TND is a self-limiting disease. If treatment is sought, various options are available that can shorten the disease course, although no one particular treatment is considered the gold standard. along the nail surface, longitudinal ridging and/ idiopathic twenty nail dystrophy, as all twenty Introduction 15 Twenty nail dystrophy (TND), also known as or pitting are almost always observed.