Cluster 1 - Downregulated genes Functional category biopolymer metabolism GO ID 43283 Raw p-Value 2.10E-11 Corrected p-Value 0.001 Number of genes 140 Frequency in set 33.49% Gene ID Gene Symbol Probe ID

9978 RBX1 218117_at 995 CDC25C 205167_s_at 994 CDC25B 201853_s_at 993 CDC25A 204695_at 991 CDC20 202870_s_at 990 CDC6 203968_s_at 983 CDC2 203213_at 9555 H2AFY 207168_s_at 951 CD37 204192_at 94239 H2AV 212205_at 9416 DDX23 40465_at 9401 RECQL4 213520_at 9232 PTTG1 208511_at , 203554_x_at 9212 AURKB 209464_at 9156 EXO1 204603_at 8975 USP13 205356_at 8479 HIRIP3 204504_s_at 8318 CDC45L 204126_s_at 8317 CDC7 204510_at 8243 SMC1L1 201589_at 8208 CHAF1B 204775_at 8099 CDK2AP1 201938_at 7443 VRK1 203856_at 7398 USP1 202413_s_at 7334 UBE2N 212751_at 7298 TYMS 202589_at 7272 TTK 204822_at 7155 TOP2B 211987_at 7102 TM4SF2 202242_at 7083 TK1 202338_at 701 BUB1B 203755_at 699 BUB1 209642_at 6839 SUV39H1 218619_s_at 6790 STK6 204092_s_at , 208079_s_at 672 BRCA1 204531_s_at 6636 SNRPF 203832_at 6632 SNRPD1 202690_s_at 6627 SNRPA1 206055_s_at 6605 SMARCE1 211988_at 6596 SMARCA3 202983_at 6502 SKP2 210567_s_at 64759 TENS1 217853_at 6447 SGNE1 203889_at 6434 SFRS10 200893_at 6432 SFRS7 201129_at 6431 SFRS6 208804_s_at 6428 SFRS3 208673_s_at 6427 SFRS2 214882_s_at 6426 SFRS1 208863_s_at 6421 SFPQ 201586_s_at 6419 SETMAR 206554_x_at 6347 CCL2 216598_s_at 631 BFSP1 206746_at 6241 RRM2 209773_s_at 6240 RRM1 201477_s_at 6119 RPA3 209507_at 6117 RPA1 201528_at 5985 RFC5 203209_at 5984 RFC4 204023_at 5983 RFC3 204127_at 5982 RFC2 1053_at 5891 RAGE 205130_at 5888 RAD51 205024_s_at 5867 RAB4A 203581_at , 206272_at 580 BARD1 205345_at 5775 PTPN4 205171_at 5591 PRKDC 208694_at 55872 TOPK 219148_at 5557 PRIM1 205053_at 5427 POLE2 205909_at 5426 POLE 216026_s_at 5424 POLD1 203422_at 5422 POLA 204835_at 54101 ANKRD3 221215_s_at 5393 PMSCL1 213226_at 5352 PLOD2 202620_s_at 5347 PLK1 202240_at 51659 Pfs2 221521_s_at 5159 PDGFRB 202273_at 51163 DBR1 219149_x_at 5111 PCNA 201202_at 51053 GMNN 218350_s_at 4998 ORC1L 205085_at 4921 DDR2 205168_at 4913 NTHL1 209731_at 4826 NNAT 204239_s_at 4751 NEK2 204641_at 4678 NASP 201969_at 4638 MYLK 202555_s_at 4436 MSH2 209421_at 4361 MRE11A 205395_s_at 4285 MIPEP 36830_at 4281 MID1 203637_s_at 4175 MCM6 201930_at 4174 MCM5 216237_s_at 4172 MCM3 201555_at 4171 MCM2 202107_s_at 3978 LIG1 202726_at 3181 HNRPA2B1 205292_s_at 3146 HMGB1 200679_x_at 3065 HDAC1 201209_at 3015 H2AFZ 200853_at 2956 MSH6 202911_at 26271 FBXO5 218875_s_at 2590 GALNT2 217788_s_at 2589 GALNT1 201722_s_at 23658 LSM5 202904_s_at 23649 POLA2 204441_s_at 23596 OPN3 219032_x_at 23594 ORC6L 219105_x_at 2353 FOS 209189_at 2342 FNTB 1773_at 2237 FEN1 204767_s_at 2175 FANCA 203805_s_at 2149 F2R 203989_x_at 2146 EZH2 203358_s_at 1854 DUT 208955_at 1786 DNMT1 201697_s_at 1665 DHX15 201386_s_at 142 ADPRT 208644_at 11335 CBX3 200037_s_at 1111 CHEK1 205393_s_at 11073 TOPBP1 202633_at 11065 UBE2C 202954_at 11041 B3GNT6 203188_at 10951 CBX1 201518_at 10733 PLK4 204887_s_at 10635 PIR51 204146_at 1058 CENPA 204962_s_at 10535 RNASEH2A 203022_at 10492 SYNCRIP 217833_at 10477 UBE2E3 210024_s_at 10432 RBM14 204178_s_at 10401 PIAS3 203035_s_at 10362 HMG20B 210719_s_at 1033 CDKN3 209714_s_at 10236 HNRPR 208766_s_at 10212 DDX39 201584_s_at 1017 CDK2 204252_at 10036 CHAF1A 203975_s_at

Functional category nucleotide binding GO ID 0000166 Raw p-Value 3.971E-7 Corrected p-Value 0.002 Number of genes 96 Frequency in set 22.96% Gene ID Gene Symbol Probe ID

6447 SGNE1 203889_at 5891 RAGE 205130_at 4921 DDR2 205168_at 1665 DHX15 201386_s_at 1373 CPS1 204920_at 10492 SYNCRIP 217833_at 5159 PDGFRB 202273_at 6150 MRPL23 213897_s_at 2130 EWSR1 209214_s_at 5825 ABCD3 202850_at 10432 RBM14 204178_s_at 6596 SMARCA3 202983_at 31 ACACA 212186_at 6434 SFRS10 200893_at 10362 HMG20B 210719_s_at 54101 ANKRD3 221215_s_at 5867 RAB4A 203581_at , 206272_at 3306 HSPA2 211538_s_at 51182 HSP70-4 219212_at 10381 TUBB4 202154_x_at 47 ACLY 201128_s_at 9401 RECQL4 213520_at 4638 MYLK 202555_s_at 10966 RAB40B 204547_at 10236 HNRPR 208766_s_at 4670 HNRPM 200072_s_at 7846 TUBA3 209118_s_at 7155 TOP2B 211987_at 1660 DHX9 202420_s_at 10801 MSF 41220_at 6426 SFRS1 208863_s_at 6431 SFRS6 208804_s_at 6428 SFRS3 208673_s_at 368 ABCC6 214033_at 5424 POLD1 203422_at 55501 CHST12 218927_s_at 5982 RFC2 1053_at 4833 NME4 212739_s_at 7283 TUBG1 201714_at 7913 DEK 200934_at 11004 KIF2C 211519_s_at 3978 LIG1 202726_at 5426 POLE 216026_s_at 8317 CDC7 204510_at 6432 SFRS7 201129_at 3835 KIF22 202183_s_at 5984 RFC4 204023_at 5347 PLK1 202240_at 4522 MTHFD1 202309_at 2956 MSH6 202911_at 6427 SFRS2 214882_s_at 7443 VRK1 203856_at 1111 CHEK1 205393_s_at 6421 SFPQ 201586_s_at 990 CDC6 203968_s_at 10212 DDX39 201584_s_at 9585 MPHOSPH1 205235_s_at

7072 TIA1 201448_at204092_s_at , 6790 STK6 208079_s_at 51593 ARS2 222047_s_at 699 BUB1 209642_at 1017 CDK2 204252_at 9416 DDX23 40465_at 8243 SMC1L1 201589_at 3181 HNRPA2B1 205292_s_at 1633 DCK 203302_at 4751 NEK2 204641_at 9319 TRIP13 204033_at 22974 TPX2 210052_s_at 5422 POLA 204835_at 5983 RFC3 204127_at 4175 MCM6 201930_at 6240 RRM1 201477_s_at 24137 KIF4A 218355_at 10592 SMC2L1 213253_at 7272 TTK 204822_at 56992 KNSL7 219306_at 4998 ORC1L 205085_at 4436 MSH2 209421_at 4172 MCM3 201555_at 983 CDC2 203213_at 10733 PLK4 204887_s_at 9212 AURKB 209464_at 5985 RFC5 203209_at 10051 SMC4L1 201664_at 701 BUB1B 203755_at 5209 PFKFB3 202464_s_at 4174 MCM5 216237_s_at 55872 TOPK 219148_at 5888 RAD51 205024_s_at 9493 KIF23 204709_s_at 10112 KIF20A 218755_at 3832 KIF11 204444_at 4171 MCM2 202107_s_at 4288 MKI67 212020_s_at 7083 TK1 202338_at

Functional category mitosis GO ID 7067 Raw p-Value 2.10E-23 Corrected p-Value 0.001 Number of genes 40 Frequency in set 9.56% Gene ID Gene Symbol Probe ID

10982 MAPRE2 202501_at 9232 PTTG1 208511_at , 203554_x_at 9700 ESPL1 38158_at 899 CCNF 204826_at 7283 TUBG1 201714_at 11004 KIF2C 211519_s_at 995 CDC25C 205167_s_at 3835 KIF22 202183_s_at 9133 CCNB2 202705_at 994 CDC25B 201853_s_at 991 CDC20 202870_s_at 11065 UBE2C 202954_at 5347 PLK1 202240_at 3619 INCENP 219769_at 990 CDC6 203968_s_at

9585 MPHOSPH1 205235_s_at204092_s_at , 6790 STK6 208079_s_at 699 BUB1 209642_at 1017 CDK2 204252_at 8243 SMC1L1 201589_at 4751 NEK2 204641_at 22974 TPX2 210052_s_at 10592 SMC2L1 213253_at 9055 PRC1 218009_s_at 10403 KNTC2 204162_at 7272 TTK 204822_at 56992 KNSL7 219306_at 4085 MAD2L1 203362_s_at 64151 HCAP-G 218662_s_at 983 CDC2 203213_at 10051 SMC4L1 201664_at 701 BUB1B 203755_at 55872 TOPK 219148_at 51203 NUSAP1 218039_at 3925 STMN1 200783_s_at 10615 SPAG5 203145_at 9493 KIF23 204709_s_at 890 CCNA2 203418_at 3832 KIF11 204444_at 993 CDC25A 204695_at Functional category nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism GO ID 0006139 Raw p-Value 2.93E-10 Corrected p-Value 0.001 Number of genes 151 Frequency in set 36.12% Gene ID Gene Symbol Probe ID

7030 TFE3 206649_s_at 9555 H2AFY 207168_s_at 6636 SNRPF 203832_at 5591 PRKDC 208694_at 3398 ID2 201565_s_at 1665 DHX15 201386_s_at 6839 SUV39H1 218619_s_at 9282 CRSP2 202611_s_at 1373 CPS1 204920_at 5631 PRPS1 208447_s_at 10401 PIAS3 203035_s_at 5757 PTMA 208549_x_at 8914 TIMELESS 203046_s_at 3015 H2AFZ 200853_at 2290 FOXG1B 206018_at 10492 SYNCRIP 217833_at 6659 SOX4 201417_at 1809 DPYSL3 201431_s_at 7089 TLE2 40837_at 6627 SNRPA1 206055_s_at 51163 DBR1 219149_x_at 2130 EWSR1 209214_s_at 6493 SIM2 206558_at 2023 ENO1 201231_s_at 10951 CBX1 201518_at 10432 RBM14 204178_s_at 25937 TAZ 202133_at 9232 PTTG1 208511_at , 203554_x_at 10935 PRDX3 201619_at 1382 CRABP2 202575_at 6596 SMARCA3 202983_at 6434 SFRS10 200893_at 8099 CDK2AP1 201938_at 2976 GTF3C2 212429_s_at 10362 HMG20B 210719_s_at 7167 TPI1 213011_s_at 7398 USP1 202413_s_at 5867 RAB4A 203581_at , 206272_at 865 CBFB 202370_s_at 5993 RFX5 202963_at 8479 HIRIP3 204504_s_at 142 ADPRT 208644_at 6632 SNRPD1 202690_s_at 47 ACLY 201128_s_at 11335 CBX3 200037_s_at 9401 RECQL4 213520_at 9551 ATP5J2 202961_s_at 23658 LSM5 202904_s_at 23594 ORC6L 219105_x_at 10236 HNRPR 208766_s_at 6605 SMARCE1 211988_at 7155 TOP2B 211987_at 3726 JUNB 201473_at 1869 E2F1 2028_s_at 10535 RNASEH2A 203022_at 6925 TCF4 203753_at 22823 M96 203345_s_at 11073 TOPBP1 202633_at 5141 PDE4A 204735_at 2983 GUCY1B3 203817_at 9994 CASP8AP2 222201_s_at 1628 DBP 209782_s_at 2354 FOSB 202768_at 4361 MRE11A 205395_s_at 6426 SFRS1 208863_s_at 115 ADCY9 204497_at 6431 SFRS6 208804_s_at 6428 SFRS3 208673_s_at 2175 FANCA 203805_s_at 5424 POLD1 203422_at 5982 RFC2 1053_at 4833 NME4 212739_s_at 7913 DEK 200934_at 4913 NTHL1 209731_at 3978 LIG1 202726_at 2146 EZH2 203358_s_at 5426 POLE 216026_s_at 6117 RPA1 201528_at 518 ATP5G3 207507_s_at 8317 CDC7 204510_at 6432 SFRS7 201129_at 10009 ZNF-kaiso 214631_at 5984 RFC4 204023_at 8204 NRIP1 202600_s_at 10036 CHAF1A 203975_s_at 631 BFSP1 206746_at 6662 SOX9 202936_s_at 3149 HMGB3 203744_at 4522 MTHFD1 202309_at 26292 MYCBP 203359_s_at 2956 MSH6 202911_at 51427 ZFD25 205739_x_at 6427 SFRS2 214882_s_at 6664 SOX11 204915_s_at 7025 NR2F1 209505_at 23589 CARHSP1 218384_at 1111 CHEK1 205393_s_at 6421 SFPQ 201586_s_at 990 CDC6 203968_s_at 6119 RPA3 209507_at 4212 MEIS2 207480_s_at 4605 MYBL2 201710_at 10224 ZNF443 205928_at 10212 DDX39 201584_s_at 2969 GTF2I 210891_s_at 1058 CENPA 204962_s_at 4678 NASP 201969_at 1017 CDK2 204252_at 9416 DDX23 40465_at 8243 SMC1L1 201589_at 23421 ITGB3BP 205176_s_at 6419 SETMAR 206554_x_at 3181 HNRPA2B1 205292_s_at 1786 DNMT1 201697_s_at 3065 HDAC1 201209_at 1633 DCK 203302_at 94239 H2AV 212205_at 3397 ID1 208937_s_at 23649 POLA2 204441_s_at 3146 HMGB1 200679_x_at 9319 TRIP13 204033_at 5422 POLA 204835_at 5557 PRIM1 205053_at 5983 RFC3 204127_at 4175 MCM6 201930_at 6240 RRM1 201477_s_at 8208 CHAF1B 204775_at 10635 PIR51 204146_at 2353 FOS 209189_at 672 BRCA1 204531_s_at 4998 ORC1L 205085_at 4436 MSH2 209421_at 4172 MCM3 201555_at 2237 FEN1 204767_s_at 8318 CDC45L 204126_s_at 5985 RFC5 203209_at 1854 DUT 208955_at 4929 NR4A2 216248_s_at 4174 MCM5 216237_s_at 580 BARD1 205345_at 5393 PMSCL1 213226_at 5888 RAD51 205024_s_at 7298 TYMS 202589_at 4171 MCM2 202107_s_at 5427 POLE2 205909_at 51053 GMNN 218350_s_at 5111 PCNA 201202_at 9156 EXO1 204603_at 51659 Pfs2 221521_s_at 7083 TK1 202338_at 6241 RRM2 209773_s_at

Functional category response to DNA damage stimulus GO ID 0006974 Raw p-Value 9.281E-11 Corrected p-Value 0.001 Number of genes 35 Frequency in set 8.37% Gene ID Gene Symbol Probe ID

5591 PRKDC 208694_at 10432 RBM14 204178_s_at 9232 PTTG1 208511_at , 203554_x_at 7398 USP1 202413_s_at 142 ADPRT 208644_at 9401 RECQL4 213520_at 11073 TOPBP1 202633_at 4361 MRE11A 205395_s_at 2175 FANCA 203805_s_at 5424 POLD1 203422_at 4913 NTHL1 209731_at 3978 LIG1 202726_at 5426 POLE 216026_s_at 6117 RPA1 201528_at 5984 RFC4 204023_at 10036 CHAF1A 203975_s_at 2956 MSH6 202911_at 1111 CHEK1 205393_s_at 6421 SFPQ 201586_s_at 6119 RPA3 209507_at 8243 SMC1L1 201589_at 3146 HMGB1 200679_x_at 8208 CHAF1B 204775_at 10635 PIR51 204146_at 672 BRCA1 204531_s_at 4436 MSH2 209421_at 2237 FEN1 204767_s_at 5985 RFC5 203209_at 580 BARD1 205345_at 5888 RAD51 205024_s_at 7298 TYMS 202589_at 890 CCNA2 203418_at 5427 POLE2 205909_at 5111 PCNA 201202_at 9156 EXO1 204603_at

Functional category cell division GO ID 0051301 Raw p-Value 3.93E-16 Corrected p-Value 0.001 Number of genes 33 Frequency in set 7.89% Gene ID Gene Symbol Probe ID

10982 MAPRE2 202501_at 9232 PTTG1 208511_at , 203554_x_at 9700 ESPL1 38158_at 899 CCNF 204826_at 3978 LIG1 202726_at 995 CDC25C 205167_s_at 8317 CDC7 204510_at 9133 CCNB2 202705_at 994 CDC25B 201853_s_at 991 CDC20 202870_s_at 1164 CKS2 204170_s_at 11065 UBE2C 202954_at 3619 INCENP 219769_at 990 CDC6 203968_s_at 699 BUB1 209642_at 1017 CDK2 204252_at 8243 SMC1L1 201589_at 896 CCND3 201700_at 4751 NEK2 204641_at 10592 SMC2L1 213253_at 9134 CCNE2 205034_at 9055 PRC1 218009_s_at 4085 MAD2L1 203362_s_at 64151 HCAP-G 218662_s_at 983 CDC2 203213_at 10051 SMC4L1 201664_at 701 BUB1B 203755_at 51203 NUSAP1 218039_at 10615 SPAG5 203145_at 9493 KIF23 204709_s_at 890 CCNA2 203418_at 3832 KIF11 204444_at 993 CDC25A 204695_at

Functional category cell cycle checkpoint GO ID 0000075 Raw p-Value 1.89E-6 Corrected p-Value 0.002 Number of genes 11 Frequency in set 2.63% Gene ID Gene Symbol Probe ID

1111 CHEK1 205393_s_at 990 CDC6 203968_s_at 699 BUB1 209642_at 8243 SMC1L1 201589_at 9134 CCNE2 205034_at 672 BRCA1 204531_s_at 7272 TTK 204822_at 4085 MAD2L1 203362_s_at 8318 CDC45L 204126_s_at 701 BUB1B 203755_at 890 CCNA2 203418_at Functional category M phase GO ID 0000279 Raw p-Value 4.141E-23 Corrected p-Value 0.001 Number of genes 44.0 Frequency in set 10.52% Gene ID Gene Symbol Probe ID

10982 MAPRE2 202501_at 9232 PTTG1 208511_at , 203554_x_at 3306 HSPA2 211538_s_at 9700 ESPL1 38158_at 4361 MRE11A 205395_s_at 899 CCNF 204826_at 7283 TUBG1 201714_at 11004 KIF2C 211519_s_at 995 CDC25C 205167_s_at 3835 KIF22 202183_s_at 9133 CCNB2 202705_at 994 CDC25B 201853_s_at 991 CDC20 202870_s_at 11065 UBE2C 202954_at 5347 PLK1 202240_at 3619 INCENP 219769_at 1111 CHEK1 205393_s_at 990 CDC6 203968_s_at

9585 MPHOSPH1 205235_s_at204092_s_at , 6790 STK6 208079_s_at 699 BUB1 209642_at 1017 CDK2 204252_at 8243 SMC1L1 201589_at 4751 NEK2 204641_at 22974 TPX2 210052_s_at 10592 SMC2L1 213253_at 9055 PRC1 218009_s_at 10403 KNTC2 204162_at 7272 TTK 204822_at 56992 KNSL7 219306_at 4085 MAD2L1 203362_s_at 64151 HCAP-G 218662_s_at 983 CDC2 203213_at 10051 SMC4L1 201664_at 701 BUB1B 203755_at 55872 TOPK 219148_at 51203 NUSAP1 218039_at 5888 RAD51 205024_s_at 3925 STMN1 200783_s_at 10615 SPAG5 203145_at 9493 KIF23 204709_s_at 890 CCNA2 203418_at 3832 KIF11 204444_at 993 CDC25A 204695_at Cluster 2 - Upregulated genes Functional category ligase activity\, forming phosphoric ester bonds GO ID 0016886 Raw p-Value 2.246E-7 Corrected p-Value 0.002 Number of genes 11 Frequency in set 2.94% Gene ID Gene Symbol Probe ID

6301 SARS 200802_at 7453 WARS 200629_at 2617 GARS 208693_s_at 16 AARS 201000_at 2058 EPRS 200843_s_at 8634 RTCD1 203594_at 4141 MARS 213671_s_at 833 CARS 212971_at 4677 NARS 200027_at 3376 IARS 204744_s_at 6897 TARS 201263_at

Functional category programmed cell death GO ID 0012501 Raw p-Value 6.284E-6 Corrected p-Value 0.004 Number of genes 39 Frequency in set 10.42% Gene ID Gene Symbol Probe ID

57761 C20orf97 218145_at 23645 PPP1R15A 37028_at 8878 SQSTM1 213112_s_at , 201471_s_at 1054 CEBPG 204203_at 1647 GADD45A 203725_at 8795 TNFRSF10B 209295_at 3313 HSPA9B 200691_s_at 331 BIRC4 206536_s_at 8535 CBX4 206724_at 4194 MDM4 205655_at 3569 IL6 205207_at 64121 RRAGC 218088_s_at 26471 P8 209230_s_at 694 BTG1 200921_s_at 1026 CDKN1A 202284_s_at 81566 C12orf22 221260_s_at 6477 SIAH1 202980_s_at 9616 RNF7 218286_s_at 7009 TEGT 200804_at 598 BCL2L1 212312_at 837 CASP4 209310_s_at 6478 SIAH2 209339_at 9093 DNAJA3 205963_s_at 4792 NFKBIA 201502_s_at 5663 PSEN1 203460_s_at 8682 PEA15 200788_s_at 7818 DAP3 208822_s_at 10116 FEM1B 212373_at 7157 TP53 201746_at 5970 RELA 201783_s_at 2309 FOXO3A 204131_s_at 7128 TNFAIP3 202644_s_at 578 BAK1 203728_at 7159 TP53BP2 203120_at 8879 SGPL1 212321_at 8877 SPHK1 219257_s_at 329 BIRC2 202076_at 7184 TRA1 200599_s_at 57099 AVEN 219366_at

Functional category translation GO ID 0043037 Raw p-Value 3.46E-5 Corrected p-Value 0.028 Number of genes 17 Frequency in set 4.54% Gene ID Gene Symbol Probe ID 6301 SARS 200802_at 7453 WARS 200629_at 1978 EIF4EBP1 221539_at 2617 GARS 208693_s_at 16 AARS 201000_at 2058 EPRS 200843_s_at 4141 MARS 213671_s_at 833 CARS 212971_at 8894 EIF2S2 208726_s_at 4677 NARS 200027_at 3376 IARS 204744_s_at 2872 MKNK2 218205_s_at 6897 TARS 201263_at 1983 EIF5 208706_s_at 4528 MTIF2 203095_at 8667 EIF3S3 201592_at 6499 SKIV2L 203727_at

Functional category protein localization GO ID 0008104 Raw p-Value 3.769E-5 Corrected p-Value 0.029 Number of genes 37 Frequency in set 9.89% Gene ID Gene Symbol Probe ID

8878 SQSTM1 213112_s_at , 201471_s_at 4864 NPC1 202679_at 10961 C12orf8 201216_at 10466 COG5 203629_s_at 868 CBLB 209682_at 10469 TIMM44 203093_s_at 6811 STX5A 203330_s_at 821 CANX 208852_s_at , 200068_s_at 6810 STX4A 203530_s_at 10040 TOM1L1 204485_s_at 51160 VPS28 218679_s_at 64215 DNAJC1 218409_s_at 11231 SEC63 201916_s_at 6747 SSR3 217790_s_at 22820 COPG 217749_at 9570 GOSR2 213180_s_at 1314 COPA 208684_at 10239 AP3S2 202399_s_at 26520 TIMM9 218316_at 10981 RAB32 204214_s_at 23423 P24B 208837_at 4792 NFKBIA 201502_s_at 5868 RAB5A 209089_at 9363 RAB33A 206039_at 10254 STAM2 209649_at 9181 ARHGEF2 207629_s_at 9546 APBA3 215148_s_at 378 ARF4 201097_s_at 23256 SCFD1 215548_s_at 7184 TRA1 200599_s_at 10043 TOM1 202807_s_at 10066 SCAMP2 218143_s_at 57403 RAB22A 218360_at 8774 NAPG 210048_at 7251 TSG101 201758_at 3841 KPNA5 206241_at 3840 KPNA4 209653_at

Functional category amino acid metabolism GO ID 0006520 Raw p-Value 3.346E-6 Corrected p-Value 0.002 Number of genes 22 Frequency in set 5.88% Gene ID Gene Symbol Probe ID

6301 SARS 200802_at 440 ASNS 205047_s_at 2673 GFPT1 202722_s_at 7453 WARS 200629_at 29968 PSAT1 220892_s_at 26227 PHGDH 201397_at 2805 GOT1 208813_at 2617 GARS 208693_s_at 16 AARS 201000_at 6472 SHMT2 214437_s_at 468 ATF4 200779_at 2058 EPRS 200843_s_at 1491 CTH 217127_at 4141 MARS 213671_s_at 586 BCAT1 214452_at 833 CARS 212971_at 4677 NARS 200027_at 3376 IARS 204744_s_at 875 CBS 212816_s_at 6897 TARS 201263_at 3155 HMGCL 202772_at 8879 SGPL1 212321_at