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The Genetic Landscape of Scotland and the Isles
The genetic landscape of Scotland and the Isles Edmund Gilberta,b, Seamus O’Reillyc, Michael Merriganc, Darren McGettiganc, Veronique Vitartd, Peter K. Joshie, David W. Clarke, Harry Campbelle, Caroline Haywardd, Susan M. Ringf,g, Jean Goldingh, Stephanie Goodfellowi, Pau Navarrod, Shona M. Kerrd, Carmen Amadord, Archie Campbellj, Chris S. Haleyd,k, David J. Porteousj, Gianpiero L. Cavalleria,b,1, and James F. Wilsond,e,1,2 aSchool of Pharmacy and Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin D02 YN77, Ireland; bFutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin D02 YN77, Ireland; cGenealogical Society of Ireland, Dún Laoghaire, Co. Dublin A96 AD76, Ireland; dMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland; eCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh EH8 9AG, Scotland; fBristol Bioresource Laboratories, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, United Kingdom; gMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, United Kingdom; hCentre for Academic Child Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1NU, United Kingdom; iPrivate address, Isle of Man IM7 2EA, Isle of Man; jCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University -
Service Review
Editorial Standards Findings Appeals to the Trust and other editorial issues considered by the Editorial Standards Committee December 2012 issued February 2013 Getting the best out of the BBC for licence fee payers Editorial Standards Findings/Appeals to the Trust and other editorial issues considered Contentsby the Editorial Standards Committee Remit of the Editorial Standards Committee 2 Summaries of findings 4 Appeal Findings 6 Silent Witness, BBC One, 22 April 2012, 9pm 6 Application of Expedited Procedure at Stage 1 14 News Bulletins, BBC Radio Shropshire, 26 & 27 March 2012 19 Watson & Oliver, BBC Two, 7 March 2012, 7.30pm 26 Rejected Appeals 38 5 live Investigates: Cyber Stalking, BBC Radio 5 live and Podcast, 1 May 2011; and Cyber- stalking laws: police review urged, BBC Online, 1 May 2011 38 Olympics 2012, BBC One, 29 July 2012 2 Today, BBC Radio 4, 29 May 2012 5 Bang Goes the Theory, BBC One, 16 April 2012 9 Have I Got News For You, BBC Two, 27 May 2011and Have I Got A Bit More News For You, 2 May 2012 16 Application of expedited complaint handling procedure at Stage 1 21 Look East, BBC One 24 December 2012 issued February 2013 Editorial Standards Findings/Appeals to the Trust and other editorial issues considered by the Editorial Standards Committee Remit of the Editorial Standards Committee The Editorial Standards Committee (ESC) is responsible for assisting the Trust in securing editorial standards. It has a number of responsibilities, set out in its Terms of Reference at http://www.bbc.co.uk/bbctrust/assets/files/pdf/about/how_we_operate/committees/2011/esc_t or.pdf. -
Electronic Health Record and Genome-Wide Genetic Data In
Wellcome Open Research 2017, 2:85 Last updated: 16 OCT 2017 DATA NOTE Electronic health record and genome-wide genetic data in Generation Scotland participants [version 1; referees: 2 approved, 1 approved with reservations] Shona M. Kerr 1, Archie Campbell 2, Jonathan Marten 1, Veronique Vitart 1, Andrew M McIntosh 3,4, David J. Porteous 2,5, Caroline Hayward 1 1MRC Human Genetics Unit, University of Edinburgh, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK 2Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK 3Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK 4Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK 5Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK v1 First published: 18 Sep 2017, 2:85 (doi: 10.12688/wellcomeopenres.12600.1) Open Peer Review Latest published: 18 Sep 2017, 2:85 (doi: 10.12688/wellcomeopenres.12600.1) Referee Status: Abstract This article provides the first detailed demonstration of the research value of the Electronic Health Record (EHR) linked to research data in Generation Scotland Invited Referees Scottish Family Health Study (GS:SFHS) participants, together with how to 1 2 3 access this data. The structured, coded variables in the routine biochemistry, prescribing and morbidity records, in particular, represent highly valuable version 1 phenotypic data for a genomics research resource. Access to a wealth of other published report report report specialized datasets, including cancer, mental health and maternity inpatient 18 Sep 2017 information, is also possible through the same straightforward and transparent application process. -
Culture, Media and Sport Committee
House of Commons Culture, Media and Sport Committee Future of the BBC Fourth Report of Session 2014–15 Report, together with formal minutes relating to the report Ordered by the House of Commons to be printed 10 February 2015 HC 315 INCORPORATING HC 949, SESSION 2013-14 Published on 26 February 2015 by authority of the House of Commons London: The Stationery Office Limited £0.00 The Culture, Media and Sport Committee The Culture, Media and Sport Committee is appointed by the House of Commons to examine the expenditure, administration and policy of the Department for Culture, Media and Sport and its associated public bodies. Current membership Mr John Whittingdale MP (Conservative, Maldon) (Chair) Mr Ben Bradshaw MP (Labour, Exeter) Angie Bray MP (Conservative, Ealing Central and Acton) Conor Burns MP (Conservative, Bournemouth West) Tracey Crouch MP (Conservative, Chatham and Aylesford) Philip Davies MP (Conservative, Shipley) Paul Farrelly MP (Labour, Newcastle-under-Lyme) Mr John Leech MP (Liberal Democrat, Manchester, Withington) Steve Rotheram MP (Labour, Liverpool, Walton) Jim Sheridan MP (Labour, Paisley and Renfrewshire North) Mr Gerry Sutcliffe MP (Labour, Bradford South) The following Members were also a member of the Committee during the Parliament: David Cairns MP (Labour, Inverclyde) Dr Thérèse Coffey MP (Conservative, Suffolk Coastal) Damian Collins MP (Conservative, Folkestone and Hythe) Alan Keen MP (Labour Co-operative, Feltham and Heston) Louise Mensch MP (Conservative, Corby) Mr Adrian Sanders MP (Liberal Democrat, Torbay) Mr Tom Watson MP (Labour, West Bromwich East) Powers The Committee is one of the Departmental Select Committees, the powers of which are set out in House of Commons Standing Orders, principally in SO No 152. -
Telescopes in Our Collection, Approximately in Date Order
©JSR2006/2009 Historic telescopes at the University of Aberdeen Historic telescopes at the University of Aberdeen Notes by Dr John S. Reid, Cruickshank Lecturer in Astronomy & Meteorology, Department of Physics. Jan 2006. Astronomy has always fascinated people of vision and imagination and it is both appropriate and fitting that some aspects of astronomy have been taught to students at the University of Aberdeen for many centuries. We have never had a separate Department of Astronomy but astronomy still forms a significant element of our degrees in Physics. Courses are also given at both levels 1 and 2 that are aimed at a wide range of BSc students and scientifically interested MA students. There are records over the centuries of interested staff acquiring telescopes on behalf of the University, extending right back to the early days in which telescopes could be purchased, namely the first quarter of the 18th century. We still possess and treasure a significant collection of historical telescopes. Not all of the recorded telescopes survive but we have by way of ‘compensation’ three late eighteenth century and nineteenth century instruments for which no acquisition records have yet been found. Over the centuries many observations have been conducted from University grounds, windows and rooftops but the University has built three observatories in the past two-and-a- half centuries. Only one survives, that on the roof of the Cromwell Tower of King’s College. The first observatory was built by Marischal College at the Castlehill in the final quarter of the eighteenth century using funds raised by public subscription. -
Genome-Wide Haplotype-Based Association Analysis of Major Depressive Disorder in Generation Scotland and UK Biobank David M
Howard et al. Translational Psychiatry (2017) 7:1263 DOI 10.1038/s41398-017-0010-9 Translational Psychiatry ARTICLE Open Access Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank David M. Howard 1,LynseyS.Hall1, Jonathan D. Hafferty1, Yanni Zeng1,2,MarkJ.Adams 1, Toni-Kim Clarke1, David J. Porteous 3,RekaNagy2, Caroline Hayward 2,4, Blair H. Smith 4,5, Alison D. Murray4,6,NiamhM.Ryan3, Kathryn L. Evans3,7, Chris S. Haley 2, Ian J. Deary4,7,8, Pippa A. Thomson 3,7 and Andrew M. McIntosh 1,4,7 Abstract Genome-wide association studies using genotype data have had limited success in the identification of variants associated with major depressive disorder (MDD). Haplotype data provide an alternative method for detecting associations between variants in weak linkage disequilibrium with genotyped variants and a given trait of interest. A genome-wide haplotype association study for MDD was undertaken utilising a family-based population cohort, Generation Scotland: Scottish Family Health Study (n = 18,773), as a discovery cohort with UK Biobank used as a population-based replication cohort (n = 25,035). Fine mapping of haplotype boundaries was used to account for overlapping haplotypes potentially tagging the same causal variant. Within the discovery cohort, two haplotypes exceeded genome-wide significance (P <5×10−8) for an association with MDD. One of these haplotypes was nominally significant in the replication cohort (P < 0.05) and was located in 6q21, a region which has been previously associated with bipolar disorder, a psychiatric disorder that is phenotypically and genetically correlated with MDD. -
Genome-Wide Meta-Analyses of Stratified Depression in Generation Scotland and UK Biobank', Translational Psychiatry, Vol
Edinburgh Research Explorer Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank Citation for published version: Generation Scotland, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Porteous, D, Deary, I, Thomson, P, Haley, C & McIntosh, A 2018, 'Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank', Translational Psychiatry, vol. 8, 9. https://doi.org/10.1038/s41398-017-0034-1 Digital Object Identifier (DOI): 10.1038/s41398-017-0034-1 Link: Link to publication record in Edinburgh Research Explorer Document Version: Publisher's PDF, also known as Version of record Published In: Translational Psychiatry Publisher Rights Statement: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. -
Generation Scotland Participant Survey on Data Collection [Version 1; Peer Review: 1 Approved, 1 Approved with Reservations]
Wellcome Open Research 2019, 4:111 Last updated: 28 APR 2021 RESEARCH ARTICLE Generation Scotland participant survey on data collection [version 1; peer review: 1 approved, 1 approved with reservations] Rachel Edwards 1,2, Archie Campbell 1,3, David Porteous 1 1Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, City of Edinburgh, EH4 2XU, UK 2MRC Human Genetics Unit, University of Edinburgh, Edinburgh, City of Edinburgh, EH4 2XU, UK 3Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, City of Edinburgh, EH4 2XU, UK v1 First published: 25 Jul 2019, 4:111 Open Peer Review https://doi.org/10.12688/wellcomeopenres.15354.1 Latest published: 13 Dec 2019, 4:111 https://doi.org/10.12688/wellcomeopenres.15354.2 Reviewer Status Invited Reviewers Abstract Background: Generation Scotland (GS) is a population and family- 1 2 based study of genetic and environmental health determinants. Recruitment to the Scottish Family Health Study component of GS version 2 took place between 2006-2011. Participants were aged 18 or over and (revision) report consented to genetic studies, linkage to health records and recontact. 13 Dec 2019 Several recontact exercises have been successfully conducted aimed at a) recruitment to embedded or partner studies and b) the collection version 1 of additional data. As the cohort matures in age, we were interested in 25 Jul 2019 report report surveying attitudes to potential new approaches to data collection and recruitment. Methods: A ten-question online survey was sent to those participants 1. Elaine Douglas , University of Stirling, who provided an email address. Stirling, UK Results: We report a high level of positive responses to encouraging relatives to participate, to remote data and sample collection and for 2. -
Directory 2016/17 the Royal Society of Edinburgh
cover_cover2013 19/04/2016 16:52 Page 1 The Royal Society of Edinburgh T h e R o Directory 2016/17 y a l S o c i e t y o f E d i n b u r g h D i r e c t o r y 2 0 1 6 / 1 7 Printed in Great Britain by Henry Ling Limited, Dorchester, DT1 1HD ISSN 1476-4334 THE ROYAL SOCIETY OF EDINBURGH DIRECTORY 2016/2017 PUBLISHED BY THE RSE SCOTLAND FOUNDATION ISSN 1476-4334 The Royal Society of Edinburgh 22-26 George Street Edinburgh EH2 2PQ Telephone : 0131 240 5000 Fax : 0131 240 5024 email: [email protected] web: www.royalsoced.org.uk Scottish Charity No. SC 000470 Printed in Great Britain by Henry Ling Limited CONTENTS THE ORIGINS AND DEVELOPMENT OF THE ROYAL SOCIETY OF EDINBURGH .....................................................3 COUNCIL OF THE SOCIETY ..............................................................5 EXECUTIVE COMMITTEE ..................................................................6 THE RSE SCOTLAND FOUNDATION ..................................................7 THE RSE SCOTLAND SCIO ................................................................8 RSE STAFF ........................................................................................9 LAWS OF THE SOCIETY (revised October 2014) ..............................13 STANDING COMMITTEES OF COUNCIL ..........................................27 SECTIONAL COMMITTEES AND THE ELECTORAL PROCESS ............37 DEATHS REPORTED 26 March 2014 - 06 April 2016 .....................................................43 FELLOWS ELECTED March 2015 ...................................................................................45 -
Biobanks in Europe: Prospects for Harmonisation and Networking
Biobanks in Europe: Prospects for Harmonisation and Networking Eleni Zika, Daniele Paci, Tobias Schulte in den Bäumen, Anette Braun, Sylvie RijKers- Defrasne, Mylène Deschênes, Isabel Fortier, Jens Laage-Hellman, Christian A. Scerri, Dolores Ibarreta EUR 24361 EN - 2010 The mission of the JRC-IPTS is to provide customer-driven support to the EU policy-making process by developing science-based responses to policy challenges that have both a socio- economic as well as a scientific/technological dimension. European Commission Joint Research Centre Institute for Prospective Technological Studies Contact information Address: Edificio Expo. c/ Inca Garcilaso, 3. E-41092 Seville (Spain) E-mail: [email protected] Tel.: +34 954488318 Fax: +34 954488300 http://ipts.jrc.ec.europa.eu http://www.jrc.ec.europa.eu Legal Notice Neither the European Commission nor any person acting on behalf of the Commission is responsible for the use which might be made of this publication. Europe Direct is a service to help you find answers to your questions about the European Union Freephone number (*): 00 800 6 7 8 9 10 11 (*) Certain mobile telephone operators do not allow access to 00 800 numbers or these calls may be billed. A great deal of additional information on the European Union is available on the Internet. It can be accessed through the Europa server http://europa.eu/ JRC57831 EUR 24361 EN ISBN 978-92-79-15783-7 ISSN 1018-5593 DOI 10.2791/41701 Luxembourg: Publications Office of the European Union © European Union, 2010 Reproduction is authorised provided the source is acknowledged Printed in Spain Reviewers Jane Kaye (University of Oxford, UK) Thorkild I.A. -
Balancing the Local and the Universal in Maintaining Ethical Access to a Genomics Biobank Catherine Heeney1* and Shona M
Heeney and Kerr BMC Medical Ethics (2017) 18:80 DOI 10.1186/s12910-017-0240-7 RESEARCH ARTICLE Open Access Balancing the local and the universal in maintaining ethical access to a genomics biobank Catherine Heeney1* and Shona M. Kerr2 Abstract Background: Issues of balancing data accessibility with ethical considerations and governance of a genomics research biobank, Generation Scotland, are explored within the evolving policy landscape of the past ten years. During this time data sharing and open data access have become increasingly important topics in biomedical research. Decisions around data access are influenced by local arrangements for governance and practices such as linkage to health records, and the global through policies for biobanking and the sharing of data with large-scale biomedical research data resources and consortia. Methods: We use a literature review of policy relevant documents which apply to the conduct of biobanks in two areas: support for open access and the protection of data subjects and researchers managing a bioresource. We present examples of decision making within a biobank based upon observations of the Generation Scotland Access Committee. We reflect upon how the drive towards open access raises ethical dilemmas for established biorepositories containing data and samples from human subjects. Results: Despite much discussion in science policy literature about standardisation, the contextual aspects of biobanking are often overlooked. Using our engagement with GS we demonstrate the importance of local arrangements in the creation of a responsive ethical approach to biorepository governance. We argue that governance decisions regarding access to the biobank are intertwined with considerations about maintenance and viability at the local level. -
Voicing Climate Change? Television, Public Engagement and the Politics of Voice
Open Research Online The Open University’s repository of research publications and other research outputs Voicing climate change? Television, public engagement and the politics of voice Journal Item How to cite: Smith, Joe; Revill, George and Hammond, Kim (2018). Voicing climate change? Television, public engagement and the politics of voice. Transactions of the Institute of British Geographers, 43(4) pp. 601–614. For guidance on citations see FAQs. c 2018 The Authors https://creativecommons.org/licenses/by/4.0/ Version: Version of Record Link(s) to article on publisher’s website: http://dx.doi.org/doi:10.1111/tran.12250 Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online’s data policy on reuse of materials please consult the policies page. oro.open.ac.uk Accepted: 16 March 2018 DOI: 10.1111/tran.12250 REGULAR PAPER Voicing climate change? Television, public engagement and the politics of voice Joe Smith | George Revill | Kim Hammond Department of Geography, The Open This paper examines a body of TV commissions made for BBC Television that University, Milton Keynes, UK formed components of the BBC Climate Chaos season (2006–2007). These com- Correspondence missions represent the first and, to date, only concerted attempt to address the George Revill Email: [email protected] issue of climate change with a range of approaches across a number of broadcast and online platforms within a public service broadcasting context across an extended season. The paper contributes to the task of balancing the relatively extensive body of research into news media coverage of climate change with that of longer form broadcast content.