Highlights from 2016/17 1 Our mission at Great Ormond Street Hospital Children’s Charity (GOSH Charity) is to enhance Great Ormond Street Hospital’s (GOSH) ability to transform the health and wellbeing of children and young people, giving them the chance of a better future. The NHS can only do so much. It meets the day-to-day running costs of the hospital, but GOSH relies on the support of all of the charity’s donors and volunteers, in order to pioneer new treatments for more children and provide the extraordinary care the hospital is so well known for. Everything you’ll see in this report was supported by GOSH Charity. And only possible thanks to people like you.

Evie is nearly three and she came to GOSH for a heart transplant.

2 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 3 The year in numbers £10m Thanks to you, this year has been an WAS RAISED incredible one for the charity. Here are through the Tick Tock Club’s third appeal towards creating some of the highlights: the world-class Dorfman Surgery Centre. £550,000 176,849 7,500 was raised by our CHRISTMAS SUPPORTERS RUNNERS PARTNERSHIP now give regular gifts took part in the record- to the charity. breaking Royal Bank of WITH Canada Race for the Kids, SAINSBURY’S raising an amazing £1 million. £13.6m 126 22,600 VOLUNTEER INVESTED BY CHRISTMAS THE CHARITY IN CHARITY AMBASSADORS MESSAGES RESEARCH were sent by supporters to support the lives of children helped us raise awareness to children on the wards with complex conditions. about GOSH in their local of GOSH through our communities. Stocking Appeal. £1,124,715 527 148 was raised at the 2016 RECORD- PARENTS AND GRANTS BREAKING FAMILIES AWARDED GOSH GALA will be able to stay at Sandwich from supporting the hospital’s Street, our new parent Play Team through to funding accommodation close to the a package of new operating hospital, every year. theatre equipment.

4 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 5 A rewarding year Being the best we can be, to build a better future

What we can achieve together never fails to astound One of the key aspects of my role as Chairman, and me. The GOSH family consists not only of those the role of all our Trustees, is to ensure that the work that work for the hospital and charity, but also our GOSH Charity supports is aligned with the most supporters and of course the extraordinary patients urgent needs of the hospital. Every day brings new and families who are at the heart of everything we do. challenges at GOSH and every donation of time This year we were delighted to welcome the children’s or money to GOSH Charity helps to meet them – medical research charity, Sparks, into our family. I’m giving young patients the best chance to fulfil their excited that together, we are set to launch the largest potential. The charity must enable GOSH to go above funding scheme of its kind in the UK – making £2 and beyond the care they would be able to provide million available for child health research. without charitable donations.

Thanks to our incredible supporters, in 2016/17 we Demand for GOSH’s care continues to rise, and I’ve were able to spend £109.6 million on building a better seen for myself how far the hospital has come over future for seriously ill children. I feel privileged to be the years. In this report we highlight how the amazing able to walk the corridors of the hospital and see the £101.8 million you helped to raise has been spent difference your donations make to young patients It’s been a busy and rewarding year, and there’s plenty and the projects that we have been proud to make close to their children while they have treatment at and their families. I hope the coming pages will allow planned for next year too. The hospital will open the possible this year. GOSH. It also included a range of medical equipment you to see this for yourself, too. Your generosity means charity-funded Premier Inn Clinical Building, the final and support projects that will improve the treatment children and young people at GOSH have access to part of the Mittal Children’s Medical Centre. We will One thing I notice more and more, is the pace at and care of children and families. life-changing medical advances through the latest cut the ribbon on brand-new parent accommodation which technology is changing. I am delighted that facilities, cutting-edge equipment and ground- and explore exciting projects like a new centre for the charity has been able to support GOSH’s vision Our work would not be possible without the tireless breaking research. It also means we can enrich the sight and sound. With support from GOSH Charity, of becoming a truly digital hospital by funding effort and dedication of our Trustees. Jennifer hospital experience with things like play and restful the hospital will expand their vital paediatric and electronic patient record and research data analysis Bethlehem, Nina Bibby, Nicky Bishop, Sandeep outdoor spaces. neonatal intensive care units, and begin work on a platforms. These systems will revolutionise the care Katwala and Michael Marrinan joined the Board of new facility that will allow doctors to perform scans and treatment of every child and impact every Trustees this year – bringing an exceptional depth The ways you’ve given your support have been as during complex surgery, ensuring the best outcomes aspect of the hospital’s work. In the future, remote of experience to the charity and reflecting our diverse as ever this year. Royal Bank of Canada Race for children with brain tumours and epilepsy. Finally, monitoring could allow more children to be assessed commitment to have the strongest governance focus for the Kids 2016 was a truly incredible day, with a one of our most transformational investments will from home, the very latest research evidence will and processes possible. I’d like to thank Steven Sharp, record 7,500 participants raising an impressive £1 start to come to life – harnessing the power of digital be on hand to inform treatment decisions, and the who stepped down this year, for his contribution as million – I’m already looking forward to this autumn’s technology in the hospital to support the very best system could even support the use of robotics. a Trustee. event! One of our landmark fundraising events – the care and experience for every single child. GOSH Gala – had its best year ever, and we celebrated This year has also seen GOSH Charity invest in, and And finally, a huge thank you to all of the charity’s the 10th anniversary of our pioneering Tick Tock Club, We couldn’t do any of this without your support, and undertake, digital projects to improve the way we supporters. Without you, the hospital would not be who have helped fundraise for some of the hospital’s we are deeply grateful that, together, we can look work. We have implemented a new way of storing the the truly exceptional place it is. Your support, and the most urgent needs. Many of you even shopped to forward to another rewarding year. records of all our supporters, ensuring we maintain extraordinary patients at GOSH, fuel the charity’s support us, when we were chosen as Sainsbury’s the very best standards of data protection and give drive to make a better future for more seriously ill Christmas charity partner. It was such a boost for us, our supporters more flexibility in telling us how they children and young people. I’m proud to be a part of it. and important to raise awareness that GOSH patients want to hear from us. We want to ensure that GOSH are in hospital, even at Christmas. Charity is exemplary in looking after our supporter’s interests, and this system will help us to do so for This year saw more supporters than ever choosing years to come. to give a monthly donation. These regular gifts help us to plan for the future, so we’re grateful for your But of course, those were not our only investments. support. We also renewed our ‘supporter promise’ – to Thanks to you, we were able to invest £109.6 million treat personal details and donations with the utmost into enabling a better future for seriously ill children. respect. In this report, you will see how our money has Tim Johnson This included progressing exciting building projects John Connolly been raised, how we spent it, and how we make the Chief Executive such as two nearby properties which will become a Chairman best use of every donation. Great Ormond Street Hospital Children’s Charity home away from home for families needing to stay Great Ormond Street Hospital Children’s Charity

6 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 7 What we raised, together

A breakdown of where our income came from in 2016/17

67% Donations

14% Legacies

6% Trading MONEY RAISED 2% 2016/17 Investment income (realised) £101.8 2% MILLION Property and other income

1% Sparks income

8% Gain/(loss) on investments

£5.7m >£2m >£88m MORE OVER RAISED RAISED OUR TARGET BY YOU THAN 2015/16 INCOME

8 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 9 Where your money went

A breakdown of where we spent our money in 2016/17

£13.6 million p16–27 Pioneering research into revolutionary gene therapy, creating tailor-made organs for transplant, and finding treatments for the most complex childhood illnesses.

Humaira, age five, in the playroom whilst waiting WE COMMIITTED for an appointment on a £37.8 million p28–39 2016/17 cancer ward. Advanced medical equipment for treating the toughest and rarest £109.6 conditions, from ultrasound scanners to MILLION new software to improve patient care, experience and research.

£7.8 million p40–49 Patient and family support services that can ease the burden on families, raise spirits, and support children and young people through their treatment.

£22.2 million p50–57 The power of every pound Rebuilding and refurbishment All of your money helps improve wards and medical facilities designed the lives of children, whether it’s around children and young people that immediately going towards one of let the hospital treat more patients in our four funding areas, helping us £ the best possible surroundings. save for large upcoming projects or allowing us to raise more money for the future. The way we spend 72.5p money can vary year on year, Charitable £28.2 million The NHS can only do so much. It meets the day-to-dayespecially if a new project such as activity Running costs and raising funds running costs of the hospital, but GOSH relies on thea building requires a large upfront helping us to run the charity and raise support of all of the charity’s donors and volunteerssum. to Because of this, we try to look at the long term relationship 27.5p more money for the future. go above and beyond, pioneering new treatments for Raising the next pound* more children and providing the extraordinary carebetween the cost of raising money the hospital is so well known for. and the donations you give us. *Average over five years

10 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 11 Aiming for a better future

We are committed to sharing our aims with you, as well as how we perform against them. Here you can see how we did in 2016/17.

Aim Achieved? Status Future

Growing

Grow our income from fundraising Yes, our income was Aim to maintain our income. and our assets to £98 million. £101.8 million. Ensure that, on average, at Yes. We achieved this Ensure we make the most of every least 70p from every £1 goes to in 2016/17 and, on pound year on year. charitable activity. average, over the last five-year period. Fundraising

Raise over £93 million from No. We raised £88 Raise £96 million. fundraising. million. Increase our fundraising activity Yes. We launched Continue to grow support in this for research. a new £50 million area, including launching a public appeal for research. appeal to raise £5 million. Investing

Support ongoing construction of Yes – ongoing. Premier Inn Clinical Building to the Premier Inn Clinical Building open in 2017–18. and Zayed Centre for Research ... Zayed Centre for Research to into Rare Disease in Children. officially open in late 2018.

Fund research, medical equipment, Yes. See more detail Continue to ensure that our patient, family and staff support on pages 16-57. funding streams meet the most projects, and rebuilding and urgent needs of the hospital. refurbishing that meets the needs of the hospital. Improving

Update and monitor our Yes. Review of Review and update all policies fundraising policies and practices practices undertaken. and practices in line with to meet the highest sector and Actions identified the revised data protection ethical standards, including being implemented. legislation, new guidance updating the way we store and New supporter and regulations. This will use supporter information. database to launch ensure effective management, May 2017. compliance and assurance for our supporters. Develop a culture of leadership Yes. Launched our Embedding our new people among our staff through our new people strategy strategy to meet our objective of people strategy. in November 2016. engaged, enabled and effective staff and volunteers.

12 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 13 Ensuring your donations make a difference

It’s my role to oversee how the charity gives funds to GOSH and, in the case of research, scientists around the country. Whenever I’m in a meeting about funding, or reading an application, it’s always in the back of my mind that everything we do is only possible thanks to the generosity of our supporters, donors, partners and volunteers. Maximising the power of every pound, including making sure that we’re thoroughly evaluating the difference we’re making, is a high priority.

Our funding process is very methodical and rigorous. It involves leaders in the field, expert committees, and our highly-experienced Trustees, who play a vital role in carefully reviewing the applications and asking tough questions (for a list of Trustees please see page 69). We check that each project aligns with one or more of the “Making sure that we ways that the charity aims to improve the lives of seriously thoroughly evaluate ill children and their families. These are known as our impact goals: the difference we're making, is a high • more children treated Lewis, age four, from • improved patient outcomes Surrey, on an isolation priority.” • better patient experience ward at GOSH. • enhanced experience for families

Making choices about what to fund, and measuring the impact of projects, is not always easy. If we purchase a piece of clinical equipment, we can count the number of young patients who have benefited. But a fundamental scientific discovery, made during research that we’ve funded, may not have an impact for years. And even then it may not be in the way that was first anticipated. However, I firmly believe that just because something is hard to evaluate, doesn’t mean we should shy away from it, and we’re striving to put clear and appropriate measures in place for the wide range of projects we support.

Measuring the impact of our funding may sometimes be difficult, but in very many cases it’s plain to see the difference your donations have made. I hope that, as you read the stories that follow, you’ll feel proud to be part of GOSH Charity. By supporting the charity this year, you have helped to change the lives of seriously ill children and their families.

Kiki Syrad, Deputy Director (Grants)

14 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 15 Kaycee, age five, has a nerve-wasting disorder and is on a clinical trial at GOSH. She is enjoying the sensory room with her dad. PIONEERING RESEARCH

With your help, this year we funded pioneering research to make discoveries that will improve the lives of seriously ill children now and in the future.

16 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 17 RESEARCH: the year at a glance

Key highlights “Without the staff working hard to Our new partnership with develop these new the children’s medical drugs and treatments, research charity Sparks will my life would be make more money available for vital child health very different to how research across the UK. p20 it is now.”

We invested in special stem Joe, GOSH patient cells that can be created from a patient’s own tissues, like skin or hair, which could hold the key to treating many conditions. p22 By increasing GOSH’s 13.6m capacity to run clinical trials, we helped more INVESTED IN children get access to RESEARCH groundbreaking treatments. to support the lives of We began a global search children with complex for world-leading cancer conditions. professors to join GOSH.

“Nina is testament to what research can do. We entered 77 a trial for untested gene therapy – it was a real risk, PIONEERING but we had run out of options. Now she is so full of life RESEARCH and mischief, just like any PROJECTS other child!”

funded by GOSH Charity. Graeme, GOSH dad

18 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 19 The new GOSH Charity family

In February 2017, Sparks, the children’s medical research charity, merged with GOSH Charity. Sparks was set up in 1991, and to-date has funded more Could a bone-forming The race to find the first ever treatment for a rare than 300 child health research projects across the super-gel treat cleft palate? brain condition UK and overseas. Sparks will continue to raise money exclusively for child health research across the UK, in Dr Richard Shelton, Professor Yanick Crow, a joint funding initiative with GOSH Charity. University of Birmingham University of Manchester

From next year, we will merge our national research Children born with a severe cleft lip Professor Yanick Crow is an expert in Labrune syndrome, an funds, making up to £2 million available. This will be and palate undergo a painful exceptionally rare and devastating condition that affects the blood the largest fund in the UK dedicated to child health operation at the age of eight to vessels in the brain. There is currently no cure. He says: “Support research, and will benefit children at GOSH, nationally repair the gap in their gum. Dr from GOSH Charity has allowed us to take advantage of a major and around the world. Richard Shelton wants to see opportunity to not only improve the diagnosis of Labrune syndrome, if he could replace this with a but to work towards the first ever cure.” Here are some examples of projects funded through groundbreaking technique that this year’s national research funds. Marked locations involves injecting the site with a are places where GOSH Charity and/or Sparks liquid gel that sets in the body projects were happening in 2016–17. and contains cells that have been programmed to form bone tissue.

When biology meets engineering – a new approach to preventing preterm labour

‘Off-the-shelf’ cells to Dr Tina Chowdhury, kill cancer Queen Mary University of London

Professor Waseem Qasim, Babies who are born too soon can have UCL Great Ormond Street Institute issues that affect them for life. A major of Child Health cause of premature birth is early rupture of the membranes, or sac, that surround the Professor Waseem Qasim wants to baby. Once they’re damaged, they can’t be create a treatment using immune repaired. Dr Tina Chowdhury is working on cells from healthy donors that, when an extraordinary innovation that will help combined with special cancer- a mother’s membranes to heal - meaning a flagging molecules, can hunt down brighter future for more children. She says: and destroy blood cancers. This “To have potentially found a way to reduce could offer the hope of cures for preterm births and prevent early deaths of even more children. young babies globally is incredibly exciting.”

20 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 21 The cells with superpowers

New stem cell technology is revolutionising the way we approach medicine. GOSH is leading the way in using these techniques to understand and treat childhood diseases.

Each of us started life as one single cell, which small sample of hair, skin or blood is all that’s contained all the instructions needed to develop needed to create a liver cell, a nerve cell or almost into a human body. Tucked away in that one any other type of cell. cell, was every scrap of information and all the foundations needed to drive the growth of the The magic of these cells doesn’t stop there. They hundreds of different cell types in our body – from hold the same genetic information as the person hair and skin cells, to nerve and blood cells. they came from, meaning they can be studied to understand that patient’s illness or to test which But how did that one first cell, create so many cells treatments might work for them. In the future, they that look and behave differently? It’s all thanks to may even be used to create a whole new organ stem cells. tailored to an individual. It might sound like the stuff of science fiction, but it’s happening right now, Under the right conditions, stem cells have the right here at GOSH, supported by funding from unique ability to become almost any cell in the GOSH Charity. body. They’re your body’s own blank canvas, primed to create biological masterpieces – from individual The implications are huge. From the potential to cells to whole organs. save a child’s sight, to building new organs and finding treatments for complex nerve disorders, A strand of hair is all you need GOSH Charity funding is allowing researchers to It’s a common misconception that adults don’t have push the boundaries of stem cell medicine. stem cells. They do. Including in our bone marrow, where they provide a lifelong supply of every type By embedding iPSC technology in our five-year of blood cell we need. research strategy, the charity will continue to help GOSH gather all the techniques, facilities and But research has led to a remarkable new era expert staff they need to keep up with this rapidly for stem cells. Scientists can now transform cells evolving area of medicine. from the hair or skin into stem cells, called induced pluripotent stem cells (iPSCs). This means a The implications are huge. From the potential to save a child’s sight, to building new organs and finding treatments for complex nerve disorders, GOSH Charity funding is pushing the boundaries of Computer-generated stem cell medicine. close up of a stem cell.

22 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 23 Reprog Creatingramming or stem editing cells under specialin the conditions lab in the lab

Stem cells can become almost any cell in the body. Researchers can now make a kind of stem cell called an induced pluripotent stem cell (iPSC) in the lab, from a patient’s own cells.

STAGE 1 b a l e th n i ons i t i ond c l a eci sp r e und ng i t i d e or ng mmi a r g o r p e R Sample taken from a patient. Building organs in the lab Saving sight Repairing nerve damage eg. Hair, blood or skin. One of our key priority areas in our Professor Jane Sowden and her Together with colleagues, Dr research strategy is regenerative team hope to use iPSCs to help Mills and Dr Tuschl, Dr Manju Reprogramming or editing under special conditions in the lab medicine – replacing, engineering save the sight of children with Kurian recently discovered a or rebuilding human cells, tissues or diseases of the retina – the layer of new disorder where the metal, Patient cells organs to restore normal function. nerve tissue that allows us to see. manganese, accumulates in the GOSH Charity have long supported Retinal diseases are the leading brain. Manganese is essential Reprogramming or the pioneering work of Professor cause of blindness in the developed for a number of important STAGE 2 editing under special Paolo De Coppi, a world-leader in world, and for many children with functions in the brain and is conditions in the lab this field. rare genetic conditions affecting found in many foods, from fruit Patient-specificReprogrammi stemng or editing under special conditions in the lab sight, there is currently no cure. to oats. It is usually handled cells created. Incredibly, over the coming years by the body with no problems, Special conditions he plans to build and transplant a Healthy retinal cells grown using but in this newly identified These are able to turn into to turn stem cells into desired cell type foodpipe (oesophagus) into a child iPSCs could be transplanted to condition, the body cannot handle almost any cell in the body. whose oesophagus has not formed restore or preserve a child’s sight. manganese properly, causing it e typ ell c d e r i s e d o t n i s ll e c m e t s turn o t ons i t i ond c l a eci p S properly. To do this, he will add a The team are also studying retinal to build up. This leads to severe child’s own stem cells to a scaffold cells from patients with genetic difficulties in movement and created using tissue from animals. conditions, to learn more about painful body spasms that worsen Stem cells Special conditions to In the future, this approach could how they differ from healthy retinal significantly over time. Sadly, turn stem cells into also be carried out using iPSCs. cells. These cells are also a good patients often lose their life to desired cell type testing ground for potential new the condition in childhood. STAGE 3 gosh.nhs.uk/regeneration sight-saving drug treatments. Stem cells become The team are growing brain cells desiredS cellpeci type.al conditions to turn stem cells into desired cell type from iPSCs to study the disease and understand why it happens. In the future they hope to use the cells to help develop treatments that This year we funded: will slow down or even reverse the • One new dedicated progression of the disease, giving state-of-the-art iPSC more children a brighter future. Nerve cell Heart cell Immune cell facility at the UCL Great Special conditions to turn stem cells into desired cell type Ormond Street Institute of Child Health (ICH), The future starts here increasing our capacity to STAGE 4 Eventually our researchers grow and study stem cells. hope to use cells like these Cells can be used • A research manager to grow full organs in the lab to test drugs, to coordinate projects that can be transplanted into understand diseases using stem cells to patients, without the risk or even transplanted construct organs. of rejection. back into patients.

24 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 25

How yesterday’s donations are changing lives today

When a new building opens or a piece of medical equipment is delivered to GOSH, the impact on patients is immediately clear to see. Other investments, like research, take longer to benefit GOSH’s young patients, but are just as life-changing.

Gabriella goes back A new frontier in Boosting clinical A step forward for a Helping families Pinpointing the causes to school muscle wasting research complex movement understand genome of life-threatening brain diseases disorder sequencing infections

APRIL MARCH 2016 2017

Rheumatic conditions affect GOSH Charity support Professor Your donations help to support GOSH Charity has supported Thanks to research that we’ve Encephalitis is swelling in the joints and soft tissues, and can be Francesco Muntoni – a world- the work of the Somers Clinical the work of Dr Manju Kurian been funding since 2015, a short brain caused by an infection. The painful and exhausting. We have leading researcher of devastating Research Facility at GOSH, giving since 2013. This year, she made animated film was produced to condition can be caused by many supported the work of leading muscle-wasting conditions like more children access to clinical the news when she discovered explain how ‘glitches’ in DNA different viruses or bacteria but rheumatology researcher Professor Duchenne muscular dystrophy trials of cutting-edge treatments. a gene that helps predict which can cause disease. This was in over 60% of cases the cause Lucy Wedderburn for many years. (DMD). A breakthrough new drug Thanks to the outstanding work children with a painful movement designed to help patients and of the infection is unknown. This Her work has improved treatment developed by his team reached being carried out there, GOSH were disorder will benefit from deep families who are considering means doctors don’t know which for children like Gabriella, who a landmark step in 2016 – being awarded an additional £3 million brain stimulation surgery. Katie undergoing genetic testing to treatment will work best. With are now able to manage their approved for use in the United investment from the National has already benefitted from the understand the intricacies of your donations, we funded work condition enough to go back to States. Professor Muntoni says: “It’s Institute for Health Research research. Her mum, Sarah, says: reading a child’s entire genetic to see if a new technique, RNA seq, school. Mum Lyn says: “Without the hard to overstate the significance (NIHR). This will allow the Facility “We’re only a few months on and code. It also helps explain how could pinpoint the exact cause. research done at GOSH, Gabriella of this approval. Before, if you to give more children with rare Katie’s already walking better and important this is for the future of In early 2017, GOSH launched the would not be going through the rite were told your son had DMD there and complex diseases the doesn’t need as much support. The understanding diseases. first testing service of its kind in of passage of starting secondary was nothing you could do. Now opportunity to join trials of future is bright.” Europe. This will help more children school with her friends.” there is hope. I am sure it’s just the brand-new medicines. gosh.nhs.uk/mygenome get life-saving treatment for brain beginning of better outcomes for gosh.org/katie infections – fast. gosh.org/gabriella these children.” gosh.nhs.uk/researchfacility

gosh.nhs.uk/dmddrug

26 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 27 Isita is five years old and is having cancer treatment at GOSH. MEDICAL EQUIPMENT

With your help, this year we provided high-tech hardware to ensure children at GOSH have access to the least invasive and most effective treatments.

28 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 29 MEDICAL EQUIPMENT: the year at a glance

Key highlights “I think defibrillators are an amazing bit From life-saving defibrillators to the of kit. Without one latest equipment that being used on me, helps diagnose genetic I wouldn’t be here. conditions quickly, this year we provided vital tools to I know CPR too.” help GOSH go above and beyond for its patients. Joe, GOSH patient We funded four of the latest ultrasound scanners. One will help to diagnose heart problems in babies before they are born, another will assist in sight- £31.5m saving operations. p32 COMMITTED TO Some of GOSH’s operating theatre equipment NEW DIGITAL needed updating, so we SYSTEMS provided funding to put the most up-to-date kit that will revolutionise patient at surgeons’ fingertips. care and research, for every child who comes to GOSH. p38 We funded a high-tech scanner that allows surgeons to view a “Thanks to a specialist patient’s spine in multiple dimensions during complex scan at 20 weeks, my spinal surgery. p36 son’s heart condition was diagnosed early and they were able to continue to monitor us both throughout my pregnancy.” Lucy, GOSH mum

30 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 31 Scanning the body with sound

This year, the charity funded a fleet of new ultrasound machines that are already benefitting young patients across the hospital.

Some of us will have had an ultrasound scan that body – with different tissues returning sound waves we won’t even remember – because we hadn’t yet at different rates. The ultrasound machine interprets made our grand entrance into the world. Pregnancy this information to create a physical image of our ultrasounds have been a routine part of maternity internal anatomy. care in the UK for decades, but this imaging technology has many other important uses at GOSH. In this way ultrasound opens a window on our insides, safely and without pain. Clinicians can use it to help When you have an ultrasound scan, your body acts as diagnose complex conditions, guide expert hands a sophisticated ‘echo’ machine. Inaudible sound waves during surgery, and make sure babies are developing sent out from the machine are reflected back by the as they should in the womb.

Original wave MEET CODY

Cody was born with a condition that affects blood vessels and can cause heart failure and problems with blood supply to the brain. His condition was spotted when routine checks showed his head was growing at an abnormal rate compared to the rest of his body. After a CT scan at his local hospital, Cody was referred to GOSH with a diagnosis of Vein of Galen malformation. Only around 10 to 12 children in the UK are diagnosed with the condition each year. GOSH is the largest specialist hospital within the UK treating these children. Cody was treated in one of GOSH’s interventional radiology suites. The delicate procedure involved using ultrasound to guide careful insertion of tiny metal coils into an artery in Ultrasound Cody’s leg. The coils were slowly worked all the machine way up to his brain to correct blood flow to the malformation. It was a long five hours for Cody’s Mum and Dad as they anxiously waited for his procedure to finish. Everything went well and Reflective wave further scans a few months later confirmed that the procedure had been a complete success. Mum Luisa said: “It was amazing… I’d spent months crying with fear and I just wanted to cry again!”

32 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 33 From diagnosis to ‘pinhole’ Delivering medication Diagnosing heart problems surgery – interventional during eye surgery before birth radiology Children undergoing eye surgery At 12 weeks of pregnancy, a baby’s Thanks to advances in imaging, may need tubes fed into their heart is no bigger than a grain clinicians can now diagnose and blood vessels to deliver medication, of rice. The structures contained treat some conditions without or injections into nerves to numb within the heart are even tinier, but, open surgery. That means less the areas around them. Getting the with the right equipment, doctors pain, a quicker recovery, and less right placement of these tubes and can diagnose some major heart time in hospital for the patient. needles is key, not only to ensure problems at this very early stage. that medication and anaesthesia At 16 weeks, with the heart still Guided by ultrasound and get to where they’re needed, only the size of a peanut, they can other imaging, interventional but also to avoid damage to diagnose even more. radiologists feed narrow tubes and surrounding tissue and long-term wires through a patient’s blood side-effects. GOSH frequently receives vessels to find the cause of their referrals of pregnant women symptoms, or even to treat the Ultrasound can help guide these from other hospitals if something MEET LUCY AND disease itself. From taking a kidney procedures, providing a clear worrying shows up on an early biopsy to fixing a narrowed blood image that allows the doctor to ultrasound scan. This year, GOSH vessel, all that’s needed is a tiny see – in real time, as they insert Charity funded a new, upgraded GEORGE two-millimetre incision in the skin a tube or needle – that the ultrasound scanner that can First-time mum Lucy was having a routine – smaller than a sesame seed! placement is perfect. produce images of a far superior pregnancy scan when the nurse spotted quality to current machines. something wrong with her baby boy’s tiny At GOSH, more than 3,000 of The Ophthalmology Department at heart. Further detailed scans showed a these intricate procedures are GOSH sees over 20,000 outpatients This is already helping the narrowed valve and a large hole between two performed each year, and demand and performs more than 400 eye hospital’s heart specialists to of the chambers. Lucy was devastated. His is always increasing. This year, your operations each year. Thanks to diagnose problems in unborn only chance of survival would be open-heart donations helped us to purchase your donations to GOSH Charity, babies at a much earlier stage surgery at around three months old. For Lucy a new ultrasound machine for the the department’s outdated of pregnancy. This gives parents and her husband it felt like a nightmare. But team. It arrived in November 2016, ultrasound machines have been and doctors more time to prepare at GOSH they knew they were in safe hands. and is already making a difference. replaced by two new, state-of-the- and plan and for some families, it “When they referred us I just felt relief,” says art scanners with excellent image may even be possible to consider Lucy. “I wouldn’t have wanted him to be Adit Dogan, Specialist quality, making procedures quicker treatment before the baby is anywhere else.” Radiographer, says: “Thanks to and safer for the children who born. These options may grow as the new ultrasound machine, need them. the exciting area of operating on Since newborns are too small for such major we have better image quality babies in the womb develops. surgery, George had to wait – with his oxygen and technology that allows us levels closely monitored – while he grew bigger to share images more readily. and stronger. At 14 weeks, George had his We’re now helping three operation and one year on Lucy explains that times as many children.” “he’s a real character, cheeky, funny, and a very happy little boy.”

34 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 35 Viewing the spine in Megan still comes to another dimension Great Ormond Street Hospital with her mum, Naomi, so doctors can check her progress. This year we helped GOSH to purchase a mobile scanner that will make complex spinal surgery safer.

Inserting metal screws next to the largest nerve super- highway in the body, the spinal cord, is among the most intricate operations GOSH performs. Just one mistake could have disastrous consequences. And yet every year at GOSH, hundreds of children undergo this kind of operation, to correct severe disorders of the spine that can cause deformity, pain, weakness and disability.

GOSH’s surgeons are experts in their field, with many successful operations under their belts, but they continually strive to reduce the risks to the child during these procedures. Every patient is different and this means each surgery brings a new challenge. To ensure the best possible placement of the pins and screws needed to repair the spine, surgeons currently use two-dimensional X-rays. This means a surgeon positions a screw and then needs to take X-rays from different angles to check the placement is correct before proceeding.

Now, in a bid to make these operations safer and reduce the need for follow-up operations, we’ve funded a mobile scanner that can be used in the operating theatre during complex spinal surgery. Shaped a bit like a donut, the impressive piece of kit gives a high-quality, multidimensional view of the spine in just one ‘spin’, MEET MEGAN helping to guide surgeons as they work. This could benefit “My condition means my spine is curved in the shape of an ‘s’. the 140 children and young people who undergo spinal We don’t know what caused it, but it happened during puberty. reconstruction and repair surgery each year at GOSH, by I was shocked when I saw my first X-ray – I had no idea my spine making the procedures safer and more accurate. was so misshapen.

“I think spinal surgery and neurosurgery “I had MAGEC metal rods put in my back at GOSH, which straightened part of my spine. They also have magnetic motors are just the tip of the iceberg for this piece in them which means that I haven’t needed to have an operation of kit. I happened to be walking along every time I grow. The doctors put a magnet against my back that causes the motor to spin around, which extends the rods. the corridor with a surgeon from another discipline and mentioned it to him. Now “Before, I wasn’t able to be very active, but the treatment means my spine is not as curved as it used to be. I am so much taller and I can he’s thinking about how he could use it. breathe properly too. I’m really excited because it means I can go to I think there will be interest from other Thorpe Park next year with my friends, which is something I couldn’t surgeons as well.” do before. I’ll also be able to do lots in PE at school and go climbing and skiing. I even did the Duke of Edinburgh’s Bronze Award in Mr Richard Reilly, September and October 2016.” GOSH Service Manager for Surgery

36 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 37 The future at our fingertips: digital innovations to transform patient care

“Medicine is predicted GOSH has embarked on a new digital project that will enhance the experience and care of all patients and families at the hospital and fuel to change more in life-changing research. Digital technology is advancing at an unparalleled allow real-time 24-hour monitoring of patients in the rate. With funding from the charity, GOSH can now hospital and, when necessary, at home – alerting if take advantage of this to help give every child and action needs to be taken, and gathering information the next decade than family the best care and experience possible. for research.

The systems we are helping to purchase will provide a This comprehensive data will drive a research and single, comprehensive clinical record for each patient, innovation platform, which will enable GOSH to carry in the previous 100 which is fully integrated with medical devices. It will out research more effectively. This could lead to provide a digital connection with patients at home prediction of catastrophic events like cardiac arrest and provide information prior to appointments. The and mine the vast volumes of gathered data to find system also holds the key to a more efficient check-in new ways to diagnose or treat complex conditions. years. We want to be process, meaning a better experience for everyone. Over 200 hospital staff have been involved in the Housing all patient data in one place will ensure plans to implement this electronic patient record (EPR) clinical staff have the most up-to-date information and research system, which will be one of the most at the forefront of about the needs and care of all their patients. important investments the hospital and charity will Clinicians will also have access to the latest research ever make. It could even allow GOSH to employ new evidence through the system, to inform complex technologies in the future, including virtual reality clinical decision making and ensure consistent and robotics. that revolution and standards of care across the hospital. The system will I can't wait to see what we can achieve A BETTER FUTURE STARTS HERE: some of the areas EPR will benefit for GOSH patients.”

More efficient Innovative Virtual reality Faster Home check-in process research and robotics diagnoses monitoring Neil Sebire, Chief Research Information Officer and Professor of Paediatric and Developmental Pathology

38 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 39 Pelesmenia, age nine, and her mum, Esmenia, get a lot of support from their charity-funded Play Specialist, Sasha Morris. CHILD AND FAMILY SUPPORT

With your help, in 2016/17 we continued to provide services to ease the burden on families, raise spirits, and support children and young people through their treatment.

40 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 41 CHILD AND FAMILY SUPPORT: the year at a glance

Key highlights “GOSH Arts was a wonderful breath We continued to fund the of fresh air on a lousy hospital’s much-loved Play morning of treatment Team. They help children and rain. Thank you come to terms with being in hospital, ease their worries, for the wonderful and let children be children, music.” even while they’re ill. p44 A new innovative system GOSH parent funded by GOSH Charity will allow the hospital to collect on-the-spot feedback from patients and families, helping to make GOSH better for everyone. p48 557 We continued to cover the costs of GOSH’s parent FAMILIES accommodation. This is SUPPORTED particularly important for by the hospital’s Citizens those whose children are Advice Service, from advice on being treated in intensive care, debt to guidance on housing and those who have travelled and immigration issues. long distances to be at GOSH.

“Through the night, when your child is in intensive care, £7.8m you need to be only a few minutes away so you can rush SPENT ON CHILD over if anything happens. AND FAMILY Parent accommodation was a big help, I don’t know how I SUPPORT would have afforded to rent PROJECTS accommodation so close.” meeting our target of Magda, Sofia’s mum spending over £5 million.

42 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 43 GOSH’s toy-toting superheroes

Spend any amount of time at GOSH and you’ll soon notice a legion clad in purple and lilac, moving purposefully around the hospital carrying teddies, buckets of bricks or stacks of books.

This colourful crew is the Play Team, who are dedicated to bringing fun into the hospital and making life as normal as possible for the children who need to be there. They can ease a child’s anxieties about being in hospital and even help them to recover more quickly. The team consists of Play Specialists and Play Workers, who work together to share their unique expertise in childcare and play.

“Taking play away from a child is abnormal. That’s what we’re here for: to try and put some normality back in an environment that isn’t normal to a child. We help children find ways to cope. We show them they can have fun and be in control in hospital.” Janet Holmes, Senior Play Specialist

THE CHARITY COVERS THE 160 38 COST OF PLAY PATIENTS AND MEMBERS OF SPECIALISTS, SIBLINGS STAFF IN THE PLAY WORKERS, In 2016, the Play Team PLAY SERVICE. interacted with more than TRAINING AND 160 patients and siblings TOYS. each day. Janet Holmes, Senior Play Specialist

44 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 45 A day in the life of a… “We looked after a child who was limiting his diet

and didn’t like the texture Play Play or feel of certain foods. Specialist Worker His Play Specialist devised activities to get him used to new sensations and mess, all via play. Within BRINGING DISTRACTING PREPARING FOR FUN INTO THE DURING PROCEDURES a short period of time he HOSPITAL PROCEDURES Letting children be children, Using activities to redirect Using techniques like role- was squelching his fingers and helping them to feel a child’s attention during play and drawing to help comfortable, relaxed procedures that are invasive, children understand their and engaged. painful or upsetting, helping illness or treatment, and through dough. His mum to ensure that they get the what will happen to them treatment they need. in hospital. was delighted with the EASING SUPPORTING MAKING change in his attitude ANXIETIES THE WHOLE MILESTONES FAMILY FUN towards food and eating.” Using therapeutic techniques Supporting parents and Delivering activities to to help children relax or carers by explaining help a child progress and overcome things that are complicated illnesses to develop, which complements upsetting them, such as children. The team also make the GOSH school and pre- needles. time to play with siblings. Mandy Byron school activity centre. Consultant Clinical Psychologist

46 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 47 On-the-spot feedback to improve patient care

This year, we funded a new system that helps Pelesmenia, age nine, having a chat with her patients, families and carers give feedback mum on the ward. more quickly and easily.

This will tell the hospital what it does well and where it can make improvements. Compared to the current system, the new ‘real-time’ feedback platform will allow visitors to give feedback at any point during their journey with GOSH, whether onsite or at home.

Children, young people and their families are at the heart of everything GOSH does. While the hospital already receives a great deal of positive feedback, they constantly strive to improve their services to better meet the needs of patients and families. This can help smooth the journey through diagnosis and treatment.

The system will incorporate the well-established NHS Friends and Family Test, but to help GOSH get to the heart of what patients need, it will also include a bank of carefully crafted questions tailored to different age groups. Children and young people will help to craft questions that cover the topics that matter to them, in appropriate language. They will also help to ensure that the system is designed to be as fun, engaging and child-centred as possible, so that everyone can take part.

48 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 49 REBUILDING AND REFURBISHMENT

With your help, GOSH’s redevelopment programme continued with the creation of patient-centred spaces to deliver world-class care for some of the UK’s most seriously ill children.

The new Premier Inn Clinical Builidng will include a new cardiac ward, benefitting patients like Connie, age three, from Essex.

50 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 51 REBUILDING AND REFURBISHMENT: the year at a glance

Key highlights “I can’t wait for Construction of the Premier my bigger, better Inn Clinical Building room on the new continued. This is the final part of the Mittal Children’s Leopard Ward” Medical Centre, due to open in 2017/18. p54 Ava, GOSH Work began on a new patient place for parents to stay close to the hospital, and the construction of the Zayed Centre for Research continued.

TV’s DIY SOS took on a challenge with a difference – transporting an award- 141 winning garden from the RHS Chelsea Flower Show BEDS across London to GOSH. p57 in the new Premier Inn Clinical Building.

“The nursing team are all incredibly happy and caring. In the new wards, the pressures of the environment will be taken away, which will definitely make us even stronger.”

Polly Livermore, GOSH Nurse Manager

52 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 53 From panthers to pelicans: the new ward animals waiting to welcome patients

A herd of exotic animals will greet children, families and staff when the hospital’s new Premier Inn Clinical Building, the second part of the Mittal Children’s 8 9 35 Medical Centre, opens its doors to patients later in 2017. BEDSWORLD -CLASS CARDIAC DAY CASE The menagerie of ward mascots were chosen after (97 inpatient,WARDS 9 ICU, INTENSIVE BEDS more than 100 GOSH children voted for their favourite 35 day case) CARE BEDS birds and animals. From the shortlist, winners were picked by medical staff – for who the wards will Outside there are become a second home. trees and flowers, outsideSPECIALITIES there is We are thrilled to report that the new creatures to bounce, stalk, crawl and soar into the wards are summer and snow. kangaroo, leopard, nightingale, alligator, chameleon, Outside there is £84m possum, panther and pelican. In GOSH tradition, the animals will be assigned to wards according to their sun and sky, 97 100 habitats, from ‘living on the ground’ on Level 2 to ‘living now we must INPATIENT INVESTED BY CHILDREN VOTED in the sky’ on Level 7. go back inside. BEDS GOSH CHARITY for the ward Choosing the ward animals was fun for all those Written by GOSH patient involved, and added to the excitement about the mascots. opening of the new building, which has taken more Ava when she was seven. than three years to construct and equip. The Premier This poem inspired new Inn Clinical Building will help GOSH to meet the ever artwork by Sister Arrow, increasing demand for its world-class clinical care. Ollie Elliot and Ross Cairns, designed to help Children – some of who will transfer from the hospital’s oldest buildings – will be welcomed into state-of-the- bring the outside into the art facilities, including spacious en-suite bedrooms. new building. As well as popping up in colourful artwork around the 11,252 clinical spaces, the ward animals will provide a unique identity that can give children a sense of belonging, SQUARE METRES even if they are far from home. of newly developed clincial space.

54 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 55 Five years of the Morgan Stanley Clinical A breath of fresh Building – the first part of the Mittal air for patients, Children’s Medical Centre staff and families As the Morgan Stanley Clinical Building, the first part “Koala Ward is an of the Mittal Children’s Medical Centre, reached its incredible place – In May 2016, the TV home improvers from DIY fifth birthday in June 2017, we look back at what this SOS worked with an army of volunteers to move charity-funded project has helped achieve so far. lovely, light and airy mountains – of soil! They transported an entire with a real family feel garden, including more than 2,000 plants, GOSH surgeon Richard Hewitt has seen the benefits four miles across central London from the RHS of the building first hand: “Patients in the Morgan to it. Emily liked to ride Chelsea Flower Show to a rooftop courtyard at Stanley Clinical Building have their own, quiet rooms, round the ward in a the heart of the hospital. helping them to get a proper night’s sleep. We know from research that proper sleep can help children little push-around car, The award-winning Morgan Stanley Garden, recover more quickly, and I’ve seen myself that these and the play facilities designed by Chris Beardshaw, was hefted into children go home sooner and that their families are were great” its new home with the help of 200 volunteers less stressed – that’s good news for everyone.” and 73 crane lifts.

Ashley, Emily’s dad The garden opened in September 2016 and has endured the test of a British winter, providing a place for visitors to rest and reflect, at any time of the year. Staff, patients and families can relax In the five years since the under the garden’s shelter and enjoy a peaceful Morgan Stanley Clinical atmosphere away from the buzz of the hospital. Building opened in June 2012: “A tranquil space, where you can just ‘be’ and not have to Monroe is two years old and having tests make any decisions or think 422 for suspected epilepsy. about anything is very rare in children have been treated for Photo of Koala kidney conditions in the British Ward hospital and it is probably the Kidney Patient Association thing you need most.” (BKPA) Centre. 6,081 Lyn, GOSH mum patients have been treated in the Wolfson Heart and Lung Centre. 13,000 procedures have taken place in its four state-of-the-art operating theatres.

56 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 57 With your support in 2017/18 we will: WITH YOUR Research Equipment SUPPORT...

•  Enable GOSH surgeons to operate on a baby with •  Purchase new specialist equipment to expand our spina bifida while they’re still in the womb, for the intensive care units, allowing the hospital to help 2017/18 promises to be first time in the UK. more critically ill babies and children. •  Invest £1.5 million to find new and better ways to •  Support work on a brand-new scanning facility that another remarkable year. treat children with cancer, by improving GOSH’s allows surgeons to capture images during brain ability to run clinical trials. surgery, giving each child the best chance of a successful operation. Our plans are ambitious, •  Fund a much-needed programme to train the next generation of surgical scientists, who will carry out •  Provide state-of-the-art equipment to help doctors innovative research in the field of surgery. diagnose and treat heart conditions without the exciting and, as always, need for open-heart surgery. child-centred. We look Support Rebuilding and forward to seeing what Refurbishment we can achieve, together.

•  Fund new projects designed to enhance the •  Complete the Mittal Children’s Medical Centre, by experience of children and families at GOSH. opening the Premier Inn Clinical Building, enabling GOSH to treat more patients than ever before. •  Enable more parents to stay close to their children, by supporting parent accommodation. •  Complete building work on new accommodation just 10 minutes’ walk from GOSH, for parents who may •  Continue to fund teams and activities that support have travelled long distances or have a child in patients and families, including the Play Service, intensive care. GOSH Arts, Social Care Service and patient parties. •  Progress construction of the Zayed Centre for Research, bringing us closer to the promise of bigger facilities with more room for groundbreaking research. •  Explore the possibility of converting one of our historic buildings into a new sight and sound clinical centre.

58 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 59 The hospital’s perspective: cells to treat what was previously considered fatal What inspires you? childhood leukaemia – we couldn’t do any of it The children we care for and their parents. So many why do we need the charity? without our supporters. lead complicated lives as a result of complex or chronic diseases. I am in awe of the burden that they The difference your support makes to children is carry and the grace with which they carry it. immense. Now, a heart valve can be replaced as a day Quite simply, GOSH wouldn’t be the place it is without procedure instead of requiring full open-heart surgery the help of the millions of donors who have supported and many days in intensive care. Simply because What would you say to GOSH Charity we now have the technology to replace the valve by supporters? it throughout its lifetime. inserting a small tube through the groin. Thank you for sharing our passion for helping children The hospital’s Chief Executive, Dr Peter Steer, sees the It’s such a pleasure to see families benefitting from who live challenging and complicated lives, and for difference your donations make every single day. the support services we can offer as a result of helping to create a better future for more children. donations. This includes our extraordinary multi-faith Thank you for helping us make discoveries that change He talks to us about what your support really means chaplaincy, our talented music and play therapists, lives not just here in the UK, but throughout the world. to the children and young people at GOSH. and a dedicated family advice service.

What are you excited about for the future of GOSH? What difference do our supporters GOSH has a 165-year history of healthcare for children, make to GOSH? leading the world in innovation and discovery. We continue to lead, and we now partner with other There is an old saying that “it takes a village to international hospitals and research institutions to raise a child”, and I see that every day at GOSH. The change children’s lives. Our unique position within the challenges our patients and families face are complex. NHS, and our commitment to universal access and They live complicated lives and we’re here to help. to becoming a leading research hospital, will ensure Thanks to our supporters, GOSH is able to provide the GOSH continues to lead internationally. We want to be very best care, with the very best equipment, in what is at the forefront of advances in children’s health in the soon to be the very best environment – thanks to new age of digital technology, genetics and big data. facilities opening over the next few years. That quality of care can help families navigate immensely difficult times in their lives. What drew you to GOSH from your I see everyone who comes into contact with GOSH, previous role as Chief Executive of Peter Steer in any way, as being part of our partnership. Children’s Health Queensland Hospital • Chief Executive of GOSH: A partnership that makes the seemingly and Health Service in Australia? 2014 – present impossible, possible. While GOSH is a national icon, not everyone in the UK • Professor in the is aware of its legendary status among paediatricians School of Medicine What difference do donations make to around the world. at the University of the running of the hospital? Queensland So many internationally renowned paediatricians Thanks to donations, the breadth of services we are have trained here and that means the hospital’s • Board member of the able to offer is profound and diverse. Every day we see impact spreads beyond the UK. There is no other Australian Provincial the incredible impact of things that wouldn’t be there children’s hospital in the UK with GOSH’s concentration Council on Children’s without them. of specialties and researchers under one roof. Health For me, this was the best job available in children’s • Distinguished career in The advanced medical equipment your donations health and it’s a privilege to work here. Being childhood medicine in have funded literally changes lives. From technology appointed Chief Executive at Great Ormond Street Australia and Canada that means we can avoid complex major surgery, to Hospital is one of the top highlights of my career. the capacity to grow entire organs in the laboratory for transplant, and genetically altering immune

60 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 61 Thank you Legacy of David Blagden The Dinosaur Trust Ashley Grote Bloomberg L.P. Domaine des Remparts Ryad Hotel Legacy of Brian Guy Our sincere thanks go to all those individuals and Legacy of Cyril Booth Spa and Golf Resort organisations who have so generously supported GOSH Legacy of Freda Bosustow Legacy of Iain Donaldson H Legacy of Andrew Boyd Legacy of Harry Dooley Häggblom and Partners Ltd Charity, through donations and Gifts in Kind, in 2016–17 Legacy of Philip Breeze The Dorfman Foundation Stuart and Lorraine Hall and those who have chosen to give anonymously. Legacy of Henry Brett Doyle Collection The Hall Hunter Foundation Legacy of Elsie Browne Duchenne UK Chloe Laura Hancock On behalf of the inspiring patients and the remarkable Legacy of Pamela Bruce dunnhumby Michael John Hancock Legacy of Angela Brunsdon Arabella Dunn and Catherine Cadbury Harlequin Football Club Ltd staff at Great Ormond Street Hospital, thank you. BT Global Services Harrison’s Fund Limited BTIG UK E Legacy of Violet Harvey John and Susan Burns eBay for Charity Legacy of Arthur Hawken FRIENDS OF ADEONA GlaxoSmithKline The Variety Club Children’s Charity Butlin’s Edge Grove School Legacy of Monica Hayes Granaway The Walt Disney Company Ltd Legacy of John Edney Headline Pictures Constance Green Foundation Garfield Weston Foundation C The Beth Egan TeamGOSH Fund Heathfield House Lord and Lady Harris The Charles Wolfson Charitable Trust Legacy of Isaiah Calleja Legacy of Robert Elliott Anne Hess Martin and Zoe Harris The Wolfson Foundation The Carmen Butler-Charteris Legacy of Arthur Elmy Alan and Christiane Hodson Hinson Jon Wood Charitable Trust Enesco The Olivia Hodson Cancer Fund The Hobson Charity Limited Richard Wright Darren Carter Legacy of Edna English Legacy of Eric Holderness Khoo Teck Puat UK Foundation The Carvill Trust Legacy of Christopher English Holland and Holland Friends of Adeona recognises our Dorothy & Spiro Latsis Benevolent Trust OTHER NOTABLE DONATIONS Charles Stanley Group Plc The Entertainer Legacy of Geoffrey Hope most generous benefactors who The Bernard Lewis Family Charitable Channel 4’s Comedy Gala Escada Legacy of Alice Horsman have helped make the hospital the Trust A Legacy of Violet Chapman Legacy of Pamela Essex Peter Howell world-class organisation it is today. Natalie and Ian Livingstone ADM Milling (UK) Ltd Niren and Aditi Chaudhary Legacy of Gareth Evans HQ Theatres & Hospitality and Qdos Marks & Spencer plc Legacy of Eileen Albury Legacy of Eugenie Chevalier Entertainment AF Foundation Harvey and Allison McGrath Legacy of Samuel Allen Children with Cancer UK F HSBC GLCM The Aghia Philothei Trust Scott and Suling Mead ALPI UK Ltd The Children’s Welfare and Research FDD International Ltd Martin and Celestina Hughes The Al Fayed Charitable Foundation Aditya and Megha Mittal Anki Foundation Legacy of Patricia Fish Legacy of Christopher Huggins ASK Italian Restaurants Morgan Stanley Gillian Anderson City Agents Club Legacy of Muriel Fisher Brad and Sian Hurrell The Barclay Foundation Her Highness Sheikha Fatima bint ArgoGlobal Viscount Clanfield Fisher Productions Legacy of Albert Hyde Sir JM Barrie Mubarak Ascential plc Naomi Clarke Formula One Management Legacy of Evelyn Hyde Heather Beckwith Mike Nelson ASK Italian Restaurants Clinique Legacy of Audrey Foster The Botnar family Newlife Foundation for Disabled Celia and Edward Atkin Close Brothers Motor Finance Franklin Templeton Investments I British Gas Children Cloud Nine Hair Tools ICandy World British Heart Foundation Oak Foundation B Legacy of Mabel Cole G The India Association - ‘Bobby’s Walk The British Kidney Patient Association Philips AVENT Legacy of David Baggott Legacy of Lysbeth Collier The Galvin Bracken Foundation Full Circle’ The Bunting family Premier Inn and Restaurants James Baggott Legacy of Lee Collyer Legacy of Brian Gamble IT&M’s Peter Pan - The British Musical Channel 4 and Addison Cresswell The Reuben Foundation The Baily Thomas Charitable Fund Nicholas Coutanche Legacy of Ivor Garrett Children with Cancer Baroness Jeanne de Rothschild Legacy of Eric Baldwin Legacy of John Cowell giffgaff J John and Odile Connolly Royal Bank of Canada Legacy of Malcom Barham Legacy of Leslie Crampton Legacy of Cecil Gilbert J Murphy & Sons Ltd Credit Suisse Securities (Europe) JN and Dame Phyllis Somers Legacy of Barbara Barrington Legacy of James Creese Davide, Azzurra and Minerva Giordano Legacy of Marjorie Jackson Limited Sir Hugh and Lady Stevenson Legacy of Dorothy Bartlett Legacy of Eileen Cruise Givergy Legacy of Gloria Janes Charles Dickens Lord Sugar and Lady Sugar Annabel Bartfeld and Jessy Global Security JJ Sweeney Ltd The Djanogly Foundation The Bernard Sunley Charitable Legacy of Eric Bateman D Globe-Trotter Legacy of Peter Johnston The Dorfman Foundation Foundation Mr and Mrs Richard Beecham Dalata Hotel Group Lydia and Manfred Gorvy Legacy of Eileen Jones The Clore Duffield Foundation Sweets for Life Ltd Legacy of Gordon Bell Legacy of Valerie D’Ambra The Shauna Gosling Trust Legacy of Sheila Jones Menashi Ephraim Tesco Legacy of Hillel Bender Legacy of Angela Van Dantzig The Alfie Gough Trust Legacy of Walter Jones Eurasian Natural Resources The Thompson Family Charitable Trust Legacy of Anne Berridge Legacy of George Davies Legacy of Pamela Gray Corporation (ENRC) PLC Towergate Charitable Foundation The Jack Bernstein TeamGOSH Fund Legacy of Colin Davis Legacy of Joyce Green K Evening Standard and Independent The Philip Ullmann Trust BGC Partners Tom Davis and Oh My Gosh Greene King PLC Kantor Charitable Trust Merrill, Amelia and Tatiana Fitzgibbons The Ulverscroft Foundation Bishopsgate School and the Delta Air Lines Legacy of Joan Gregory Eugenie Kamasa United Biscuits Bishopsgate Ball Committee The DG Charitable Settlement Sarah Gridley Legacy of Ranjanbala Karia

62 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 63 Legacy of Terence Kelly Legacy of Ann Mitchell Retro Computers Ltd T APPEALS, FUNDRAISING COMMITTEES Kenny Wax Ltd - Peter Pan Goes Wrong Legacy of Vera Mitchell Legacy of Edward Richardson Andrew Taee and Charity Clay Pigeon AND PATRONS 2016/17 Carol Concert 2016 Kent Reliance The Monarch Group Legacy of Christopher Roderick Shoot Limited Legacy of Kathleen Kendall Piers Morgan Rosewood London The Tanlaw Foundation Kingpin Communications Morgan Stanley The Countess of Rothes Legacy of Joan Taylor Room to Legacy of Jack Kirkland Legacy of Roderick Morison Legacy of Margaret Rowley Legacy of Margaret Terroni ARRT Society Champagne Garden Party Breathe Conor Kitching Legacy of Barbara Mosley Royal Bank of Canada Tesco A heart-warming family event of carols

Legacy of Patricia Koenraads J P Moulton Charitable Foundation The Royal National Hotel The Thompson Family Charitable Trust THE and readings from special guests Legacy of Mary Krins Muscular Dystrophy UK RUSH Thomas Cook Children’s Charity and patients at St Pauls Church, Kuehne + Nagel Chris Rush Thomsons Online Benefits SOCIETY Knightsbridge. All funds raised went N Legacy of Judith Ryland Legacy of Beryl Thomas towards Room to Breathe, a three-year L Legacy of John Nathan Legacy of Winifred Thorne A family friendly afternoon of live appeal to raise £1 million towards the Lazard National Theatre S James and Rosie Thornton music by The Arts Club, magicians, redevelopment of the respiratory ward. Scott Leah Legacy of Mary Nixon Sainsbury’s Supermarkets Tobar Group Trading Ltd a barbecue and much more. Geoffrey Lee Andrew Norton Legacy of Irene Sallis Tokio Marine Kiln Chair Legacy of Annie Leonard Norton-Freeman Charitable Trust Samuel French Inc, New York Stanley and Beatrice Tollman Chair Stephanie Léouzon Les Trois Rois Samuel French Ltd, London Legacy of Amelia Toyn Tom Hodson Legacy of Annie Levett O Legacy of Edward Sandy Toys R Us and Kit for Kids Group Co-Founder Bernard Lewis Family Charitable Trust Legacy of Howard O’Hara Legacy of Berenice Saxby Lindsay Tufft Committee Bridgett Walters James Lewis Foundation One Great Day Scorpio Group Legacy of Gwendoline Tyler Rebecca di Sora Legacy of Turner Layton Orient Corporation Benjamin Scott India Goss Committee Legacy of Thomas Linehan Legacy of Catherine Searle U Freddie Parker Anita Bott Legacy of Evelyn Lines P Ian and Carol Sellars Uniserve (Holdings) Ltd Alessandro Raspa Jo Broadhead Legacy of Irene Ling PageGroup Aria Seth The Utley Family Charitable Trust Rosanna Ruff Antonia Christie Little Baby Bum (El Bebe Legacy of Karin Page ShareGift Katie Trueman Susi Clement Davies Productions Ltd) Mark Palmer The Jasper Sherlock TeamGOSH Fund V Vanessa Colomar Legacy of Margaret Lound Legacy of Gwyneth Parry Silver Levene LLP Victoria’s Secret Kelly Curtain Legacy of Hugh Pearson Jonathon Slack Nick Ede M Legacy of Ruth Pearson Slimming World W Tara Falk Legacy of Betty Maconchy The Earl Peel Small Luxury Hotels of the World™ Marjorie Walker Brighter Future Funds Sarah Golding Maidwell Hall School Legacy of Henrietta Perkins Bethany Smith Legacy of Eileen Wallman Matthew Hurlock Legacy of Pamela Majaro Peter Pan – the American Musical Dr Dermot Smurfit Legacy of Patrick Walsh Amanda Husson Mark Stolkin Foundation Peters & Peters Solicitors LLP Sophie’s Steakhouse The Walt Disney Company Ltd Timothy Knatchbull Marks & Spencer plc The Rowan Pethard TeamGOSH Fund Ramez and Tiziana Sousou Legacy of Doris Warwood Natasha Leith-Smith Brighter Future Fund Legacy of Rona Marsden PF Charitable Trust Legacy of Mary Southern Peter Watts Eugène Léouzon Legacy of Keith Martin 3.1 Philip Lim Legacy of David Southgate Legacy of Nicholas Webster Brighter Future Funds have continued Alison Loehnis The Mahboubian Family Trust Heating Plumbing Supplies Ltd Legacy of Bernard Speer Legacy of Alfred Westwood to raise incredible amounts in loving Patty Madara Max’s Foundation Rob Pomphrett James and Dorothy Spicer Legacy of David Wharam memory of: Eileen Mannion MBNA Premier Inn and Restaurants Sir Howard Panter and Rosemary whizzbo Limited Simon Moore Geraldine McCaughrean Legacy of Amanda Price Squire OBE Legacy of Margaret Wiles Ollie Anstey Alice Page Macfarlanes LLP Legacy of Caroline Prior Stella McCartney Kids Legacy of Linda Wilkinson William Andrew Joshua Crook Luciana Redi Legacy of Julie McKnight Legacy of Gavin Puddifoot Henrietta St George Wilko Toby Hambrook-Skinner Martizina Slater Legacy of Robert McWatt The PwC Foundation St John’s School, Northwood The Wolfson Foundation Lennie Ives Jennifer Spink Scott and Suling Mead Stiles and Drewe’s Peter Pan – A Jon Wood Kyan and Anaiya Khattran Murray Stroud Legacy of Kenneth Meekin Q Musical Adventure David Wyatt Anna Lewis Dawn Vernon The Mercers Company Qubic Tax Stelios Philanthropic Foundation Tyler Stephen Reader Naomi Weinberg Berk The Mikheev Charitable Trust The Sterling Dental Foundation X Darcey Leigh Shaw Susan Wells Legacy of Leslie Miller R Legacy of Brian Stevens Xchanging, a CSC company James William Shaw Legacy of Patricia Milsom Raamin4Charity and the Race Across Stork XTX Markets Rory Spinks The Laurence Misener Charitable Trust America team Matteo Stokes Golf Day Heidi Taylor Mischief Theatre – Peter Pan Goes The Gordon and Tana Ramsay Lord Sugar and Lady Sugar Aran Varsani Wrong Foundation Sweets for Life Ltd Mitsubishi Pencil Company Johnny Reay and family

64 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 65 Jacques Malone Madeleine Macey Andrew Taee (until November 2016) Corporate Partnerships Board Iain O’Rourke HAIRraising Love GOSH Eloise Margoline Lady Madeline Lloyd Webber (from 1 A network of industry leaders who Linda Panahpour Iza Minkiewicz January 2017) help GOSH Charity secure mutually- Cristina Rashidian HAIRraising Salons go to all lengths for kids Rebecca Mitchell Andrew White (until November 2016) beneficial corporate partnerships. Dr Dermot Smurfit Marissa Montgomery An initiative to bring the hairdressing A valentines themed evening raising Martine Montgomery Members Chair community together to raise funds for money for a single bedroom in the new Saskia Winbergh 4 Charity Foundation Simon Smith the new respiratory ward due to open cardiac ward opening in early 2018, Amie Witton-Wallace Mr and Mrs Terence Adams in early 2018. and life-saving defibrillators. Nick and Kate Austin Board Members GOSH Gala Junior Committee The Balasuriya Family

Marc Allera THE Founder Chair Francesca Boschetto Mr Tony Ball Matteo Canonaco John Frieda Tara Falk Laura Gabriele The Barclay Foundation David Craig Layann Masri Mr and Mrs Peter Beckwith Jonathan Grundy Patrons Committee Harry Osborne The Beecham Family Steve Ingham A Narnia-themed fundraising gala. Julietta Dexter Natalie Avvoltoio Alexandra Samaras Alan and Sara Bennie Chris Jansen Jayne Lewis-Orr Tom Cox Sophie Smurfit Emily and Len Blavatnik Cyrus Kapadia Chair Rush James Furlonge Mr Bobrovnikov and Mrs Chernavskaya Audrey Klein Ken Costa Alex Goward The Bunting Family John O’Higgins Janet Henderson John and Susan Burns Matthew Ponsonby Committee Jennifer MacArthur CBRE Tim Score Dominic Collins and Rosie Henderson Rebecca Mitchell Tick Tock Club Jason and Belinda Chaffer Dave Thomas Rory and Benjama Fleming OSCAR Jane Ratcliffe Mr and Mrs Joe Chambers Georgina Vaughan Antony and Amanda Jenkins Andrea Thompson The Chilton Family John Waples Hubert and Caroline Keller OSCAR Susan Wells Sir Trevor and Lady Chinn Afsi Moshiri John Coldman Jonathan and Jennifer Oppenheimer An appeal created to unite the S and J Cooper Matthew Riley international shipping community by A giving club, set up to address the Richard and Lucinda Cormack Nana Sao and Zeze Oriaikhi-Sao raising money for childhood cancers hospital’s most urgent needs. The Club Mr and Mrs Ken Costa Friendship Ball Ramez and Tiziana Sousou and immune disease research. Shop Wear Care is now in its fourth appeal – raising Josh and Elizabeth Critchley Jeremy and Bumble Sparrow funds for a new state-of-the-art The Peter Cruddas Foundation Chair intra-operative MRI scanner. Dr Genevieve and Mr Peter Davies Phil Parry Ian and Penny Davis Chair The DG Charitable Settlement Board Members An exclusive shopping event, where Grahame Chilton (until November 2016) Sarah and Lloyd Dorfman GOSH Charity and The Children’s The GOSH Matchplay Cup Julian Bray leading fashion designers donate Rosemary Squire OBE (from 1 January The Dorfman Foundation Medical & Research Foundation at Laura Bugden collections for guests to purchase at a 2017) Alex and Tara Easton Our Lady’s Children’s Hospital, Crumlin Guy Campbell discounted retail price with all income Tamara Ecclestone joined forces to raise money for cardiac Crispin Eccleston going directly to the charity. Patron André Elshout and Mike Elms research at both hospitals. Richard J Fulford-Smith Gary Lineker OBE The Entertainer A unique golf event at Stoke Park to Richard Greiner Chair Michael and Francesca Evans Chair raise money for the hospital’s most Mark Jackson Sayoko Teitelbaum Board Members FDD International Ltd Ron Boschetto urgent needs. Andrew Jennings Amy Dorfman (from 1 January 2017) Dorothée and Pierre-Henri Flamand Paul Jennings Committee Louise Galvin (from 1 January 2017) The Galvin Bracken Foundation Committee Chair Robin King Juliet Angus David Haggie (until November 2016) Gary and Catherine Grant Thoraya Bartawi Tim Stansbury Julie Lithgow Samantha Bauer Steve Jacobs (until November 2016) Green Hall Foundation Linda Boschetto Nicholas P Lockyer Pilar Boxford Sachin N Khajuria (until November 2016) Charles and Kaaren Hale Viscountess Clanfield Committee Mark Long Lisa Bridgett Kelly Luchford (from 1 January 2017) Robert Hall Foundation Kyle Dargan Ed James Greig MacPherson Georgina Cohen Gilberto Pozzi (until November 2016) Mrs R E Heale Cyril Delamare Marcus Jansa Brain Perrott Patricia Dente Haimes Kamal Rahman (until November 2016) The Higgins Family Rainer Häggblom Lee Spink Mark Stokes Deana Goldstein Mark Sartori (until November 2016) The Hobson Charity Limited Bernard Heffernan Nick Stewart Raffaele Zagari Carolina Gonzalez-Bunster Tom Stone (until November 2016) Alan and Christiane Hodson Diane Kordas Jason Stoop James Wilkes Alison Henry Alison Swinburn (from 1 January 2017) Brette and Gordon Holmes Roger Macey Mark Worrall

66 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 67 Brad and Sian Hurrell The Sareen Foundation CHARITY TRUSTEES, DIRECTORS AND Oleksandr Iaroslavskyi The Sartori Family Valentine’s Party, Big Hearts for RESEARCH ASSESSMENT PANEL Steve Jacobs Ian and Carol Sellars Little People David and Elizabeth James Osman and Claudia Semerci VALENTINE’S The Jenkins Family The Shanly Foundation Nick and Linda Johnston Dominic Shorthouse PARTY Trustees Research Assessment Panel Directors Rose Marie and Erland Karlsson Andrew and Blanche Sibbald BIG HEARTS John Connolly (Chairman) FOR LITTLE PEOPLE Mr and Mrs Nagi R Kawkabani John Sibree and family Diana Dunstan OBE Chair Chief Executive Mr Sachin Khajuria Standard Chartered plc A valentine’s themed family fundraising Margaret Ewing Professor Stephen Holgate Tim Johnson Philip King Charitable Trust Sir Hugh and Lady Stevenson event to raise funds for private en-suite Kaela Fenn-Smith The Lake House Foundation Robert Stirling bedrooms as part of the hospital’s David Claydon Members Director of Communications Zayn Lakhani & Family Angela and Tom Stone redevelopment. Mark Sartori Professor John Anderson Cymbeline Moore Jude Law Lord Sugar and Lady Sugar Steven Sharp (resigned 23 Professor Michael Beresford Jason Leonard OBE Alison Swinburn Co-chairs December 2016) Professor Jill Clayton-Smith Director of Corporate Partnerships Eugène and Stephanie Léouzon Bobbi Hernandez and Morgan Sze Samantha Bauer Frances Murphy (deceased 25 Professor David Edwards Amit Aggarwal Keith and Muriel Lipman Andrew and Katrina Taee Sayoko Teitelbaum May 2016) Dr Lee Elliott Major (until October 2016) The Lotus Foundation The Taylor Family Foundation Sandeep Katwala (appointed Professor David Goldblatt Director of Finance and Operations Gavin and Luise MacDonald Chris and Carole Taylor Committee 10 January 2017) Baroness Margaret Jay Ian Chivers Charly Malek and The Thompson Family Maryam Akhavan Jennifer Bethlehem (appointed Dr Colin Michie Alessandra Steinherr Charitable Trust Patricia Dente Haimes 10 January 2017) Ms Miranda Pink Director of People and Planning Charles and Sophia Mason Richard and Susan Thornton - The Alex Demong Nicky Bishop (appointed Professor Anne-Marie Rafferty Heather Morgan The Maaike McInnes Thornton Foundation Zeina Embiricos 10 January 2017) Professor Rosalind Smyth Charitable Trust Ben and Harriet Thorpe Alys Garman Nina Bibby (appointed 10 January 2017) Professor Maria Quigley Director of Major Gift and Special Matt and Emma Stanley and Beatrice Tollman Nicole Gazal O’Neil Michael Marrinan (appointed Dr Chris Verity (until October 2016) Event Fundraising Scott and Suling Mead Laura and Barry Townsley Deana Goldstein 16 February 2017) Neal Donnelly George Michael and Kenny Goss The Toy Trust Tami Goven Mitch and Alison Moore Amanda and Dominic Vail Shona Hampel Associate Trustees Director of Marketing and Hilton and Louise Nathanson CT van Hoorn Charitable Trust Elizabeth Hawtin Simon Stormer Public Fundraising Fiona and Andrew Neale Vivid Imaginations Arianne Kamyab Ruary Neill Richard Bowyer Andrew and Marina Newington Alasdair Warren Bianca Ladow Humphrey van der Klugt Christopher and Emily O’Donoghue Garfield Weston Foundation Patty Ladow Chris Morris Amicia and Richard Oldfield Michael and Rachel Weston Iza Minkiewicz Dr Benjamin Jacobs Mr and Mrs Harry Owen Mr and Mrs Andrew White Leila Moghadam (appointed 1 May 2016) Sir Howard Panter and Rosemary Mr and Mrs Roger Wyatt Blaine Peck Professor Mary Rutherford Squire OBE Louise Redknapp (appointed 1 May 2016) Francesco Pascuzzi Lisa Reuben Elizabeth and Daniel Peltz Saskia Winbergh Simon Picken QC and Dr Sophie Picken Paul Pindar Tick Tock Club Charity Fundraising Patrons Gilberto Pozzi Golf Day Susan Burns The Presidents Club Grahame Chilton Charitable Trust Chair Ken Costa Alexandra Raphael and Family Paul Roy Andrew Taee The Reuben Foundation Lady Estelle Wolfson of Marylebone Jane and Nick Robinson Committee Stuart and Bianca Roden Alan Bennie Ambassador The Rothermere Foundation Huw Jenkins Jason Chaffer The Countess of Rothes Andrew White The Roy family Matthew Wright Charity Patrons The Dr Mortimer and Theresa Sackler Tess Daly Foundation Vernon Kay The Basil Samuel Charitable Trust

68 Great Ormond Street Hospital Children’s Charity Highlights from 2016/17 69 Sadie, age one, is on Miffy Ward while her mum learns to use the ventilator equipment before they can go home.

70 Great Ormond Street Hospital Children’s Charity