Host Cell Protein Knowledge Accelerator Go Beyond ELISA and Learn What SWATH® LC-MS Can do for Your Host Cell Protein Analysis Unbeatable Sensitivity with Unbiased Host Cell Protein Detection
Host cell proteins (HCPs) can adversely affect drug safety, making it critical that these HCP contaminants can be accurately detected and identified during biotherapeutic development.
LC-MS/MS not only enables you to fully detect and characterize HCPs in a biologic preparation. Unlike polyclonal ELISA-based methods which only provide a total HCP level, the SCIEX SWATH-based method provides estimates of individual HCP quantities. SWATH® Acquisition provides unbiased sampling for detection of low-level HCPs – even those that were previously unknown.
Resources
ALL High Sensitivity Host Protein Quantitation in MS/MS with SWATH® Acquisition an IgG1 Monoclonal Antibody Preparation via Data-Independent Acquisition
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The Optimization of Simultaneous Quantitative Peptide Host-Cell Protein Detection Mapping and Host Cell Protein Detection Using Data Independent in a Recombinant IgG1 Monoclonal SWATH MS Antibody Preparation using Data-Independent Acquisition
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Visit our Application Page to Learn More: Host Cell Protein Detection and Quantitation 2 Dr. Thomas Kofoed CEO, Alphalyse
“Mass spec is going to be the gold-standard for HCP analysis, as it provides more detailed information about individual HCPs compared to ELISA assays. Adding SWATH Acquisition for unbiased identification and quantification of proteins leads to high reproducibility and sensitivity. With this solution, standardization of the methods to any given set of biotherapeutic samples becomes possible, providing us with a huge advantage.”
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Webinars
Identify and Quantify Individual SWATH-MS HCPs Profiling Host Cell Proteins – Does Your and Absolute Quantification HCP ELISA Measure Up? of Key Impurities
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Single Digit PPM Level Identification Characterization of Host-Cell of Host Cell Protein Contaminants Using Proteins Using Mass Spectrometry a Simple One Hour SWATH Enables Effective Purification Acquisition Method Optimization Read More Read More
Visit our Application Page to Learn More: Host Cell Protein Detection and Quantitation 3 SCIEX Now™ Support Network The Destination for All Your Support Needs
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