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Supplemental Material 1 Supplemental Table I. List of genes altered by miRNA mimics in DC and Mφ. Highlighted genes indicate predicted targets Dendritic Cells miR-24 miR-30b miR-142-3p Fold Change Fold Change Fold Change Gene Ratio Gene Ratio Gene Ratio Inhib/Mimic Inhib/Mimic Inhib/Mimic Phospholipase C, beta 1 DIRAS family, GTP- 149.09 Mannose receptor, C type 1 129.79 (phosphoinositide- 49.87 binding RAS-like 3 specific) Macrophage receptor with Macrophage receptor with Toll-like receptor 6 74.03 78.25 44.63 collagenous structure collagenous structure Mannose receptor, C Fc fragment of IgG, low Mannose receptor, C type 48.84 38.59 32.90 type 1 affinity IIa, receptor (CD32) 1 Fc fragment of IgG, Fc fragment of IgG, low C-type lectin domain family 7, low affinity IIa, 24.59 35.02 affinity IIa, receptor 29.65 member A receptor (CD32) (CD32) C-type lectin domain 18.00 Toll-like receptor 4 32.67 CD14 molecule 24.93 family 7, member A DIRAS family, GTP-binding Toll-like receptor 4 17.51 20.97 Toll-like receptor 6 24.08 RAS-like 3 Macrophage receptor Fc fragment of IgE, high with collagenous 16.91 affinity I, receptor for; alpha 19.97 Toll-like receptor 4 21.41 structure polypeptide Fc fragment of IgE, Fc fragment of IgE, high high affinity I, receptor 16.34 Toll-like receptor 6 17.03 affinity I, receptor for; 20.68 for; alpha polypeptide alpha polypeptide Phospholipase C, zeta Fc fragment of IgE, low C-type lectin domain 11.08 9.51 15.56 1 affinity II, receptor for (CD23) family 7, member A Phospholipase C, beta Actin, alpha 1, skeletal 1 (phosphoinositide- 9.13 CD14 molecule 9.32 13.45 muscle specific) Ras-related C3 botulinum Fc fragment of IgE, Macrophage scavenger receptor toxin substrate 2 (rho low affinity II, receptor 7.89 7.11 11.55 1 family, small GTP binding for (CD23) protein Rac2) Toll-like receptor 1 7.57 Lymphocyte antigen 86 7.06 Phospholipase C, beta 2 9.92 CD14 molecule 7.36 Toll-like receptor 1 6.28 Toll-like receptor 1 9.45 Fc fragment of IgE, low Toll-like receptor 9 5.21 Lymphocyte antigen 96 5.94 affinity II, receptor for 8.51 (CD23) Lymphocyte antigen 5.10 Complement component 3 5.10 Fibronectin 1 8.00 96 Ras-related C3 botulinum toxin Toll-like receptor 5 4.66 substrate 2 (rho family, small 4.63 Toll-like receptor 9 7.41 GTP binding protein Rac2) Ras-related C3 botulinum toxin substrate 2 (rho family, 4.63 Toll-like receptor 3 4.53 Toll-like receptor 2 5.94 small GTP binding protein Rac2) Macrophage scavenger DIRAS family, GTP- 4.59 Mannose receptor, C type 2 4.20 5.66 receptor 1 binding RAS-like 3 Complement 4.53 Phospholipase C, zeta 1 4.06 Phospholipase C, zeta 1 5.39 component 3 Lymphocyte antigen 4.08 Toll-like receptor 5 2.99 Lymphocyte antigen 86 5.35 86 5.24 Phospholipase C, beta Phospholipase C, gamma 3.71 Phospholipase C, gamma 2 2.91 2 2 Fc fragment of IgE, high Mannose receptor, C 3.66 affinity I, receptor for; gamma 2.87 Toll-like receptor 3 5.03 type 2 polypeptide Mannose receptor, C type Protein kinase C, beta 2.95 Phospholipase C, beta 2 2.77 4.92 2 Fc fragment of IgE, Toll-interleukin 1 receptor high affinity I, receptor 2.93 Fibronectin 1 2.08 (TIR) domain containing 4.66 for; gamma adaptor protein polypeptide Phospholipase C, gamma 2 Phosphoinositide-3-kinase, Macrophage scavenger 2.79 1.96 4.53 (phosphatidylinositol- regulatory subunit 2 (beta) receptor 1 specific) Phosphoinositide-3- Fibronectin 1 2.51 Phosphoglycerate kinase 1 1.96 kinase, regulatory subunit 4.41 1 (alpha) Toll-like receptor 3 2.38 Protein kinase C, beta 1.95 Lymphocyte antigen 96 4.32 Phosphoinositide-3- Fc fragment of IgE, high kinase, catalytic, 2.04 affinity I, receptor for; 4.03 gamma polypeptide gamma polypeptide Single immunoglobulin Toll-like receptor 2 2.01 and toll-interleukin 1 3.63 receptor (TIR) domain Phosphoinositide-3- kinase, regulatory subunit 3.61 2 (beta) Phospholipase C, beta 4 3.51 Protein kinase C, beta 3.36 Ras homolog gene family, 3.34 member B Ras homolog gene family, 3.27 member D Ras homolog gene family, 2.77 member A Mitogen-activated protein 2.71 kinase kinase kinase 7 Phospholipase C, delta 1 2.69 Protein kinase C, epsilon 2.45 Mitogen-activated protein 2.38 kinase 14 Wiskott-Aldrich 2.31 syndrome-like Protein kinase C, alpha 2.03 Macrophages miR-24 miR-30b miR-142-3p Fold Change Fold Change Fold Change Gene Ratio Gene Ratio Gene Ratio Inhib/Mimic Inhib/Mimic Inhib/Mimic Fc fragment of IgE, high Mannose receptor, C type Rho family GTPase 3 6.15 affinity I, receptor for; alpha 67.65 15.24 1 polypeptide Fc fragment of IgE, high Phospholipase C, zeta 1 23.75 affinity I, receptor for; 2.94 alpha polypeptide Macrophage receptor with Mannose receptor, C type 1 14.52 2.29 collagenous structure Protein kinase C, alpha 2.35 Protein kinase C, alpha 1.95 Macrophage receptor with 2.10 collagenous structure Ras-related C3 botulinum toxin substrate 2 (rho family, small 2.00 GTP binding protein Rac2) .
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