Robotics Technology

Total Page:16

File Type:pdf, Size:1020Kb

Robotics Technology Urol Clin N Am 31 (2004) 793–800 Robotics technology: a journey into the future Abhilash Pandya, PhD*, Gregory Auner, PhD Department of Electrical and Computer Engineering, Wayne State University, Engineering Building #3160, 5050 Anthony Wayne Drive, Detroit, MI 48201, USA The authors predict that technology-assisted Even with enormous technologic gains, robotic medicine, and robotics in particular, will have surgery is still in its infancy. Some major techno- a significant impact over the next few decades. logic improvements are needed for this technology Robots will augment the surgeon’s motor perfor- to reach its ultimate potential, including better mance, diagnosis capability, and senses with visualization, tactile sensing, diagnostic sensing, haptics (feel), augmented reality (sight), and and miniaturization [27]. This article gives the ultrasound (sound). Robots already boost surgical authors’ vision of the future of robotic technology skills by filtering tremor and scaling motions, but with respect to robotic vision, sensor fusion, and may be able to automate certain routine tasks to nano-/microrobot development and discusses the free the surgeon to focus on higher-level tasks. path to that future from the current state-of-the- With intelligent interfaces, the robotic system art for medical robots. could warn surgeons of incorrect trajectories or restrict the movements of the surgery away from Robotic vision (augmented reality and image dangerous or critical areas. The authors predict guidance) that the impact of robots will parallel that of imaging technology in medicine today. Many studies have compared and improved Robotic devices have been used in cardiac the surgical interface and improved the surgeon’s surgery [1–13], urology [14–16], fetal surgery performance [28–31]. One of the key problems of [17,18], pediatrics [19–22], neurosurgery [23,24], robotic surgery, however, is that surgeries can orthopedics [25,26], and many other medical become more difficult and take longer [32].In disciplines. As with imaging technology, robotics robotic surgery, the magnification and, therefore, will bring patient care and treatment a leap for- the size of the field-of-view changes with the ward. In several cases, it has started to happen proximity of the endoscope to the objects being already. In particular, the Vattikuti Urology In- viewed [33]. Because of the small incisions and stitute at Henry Ford Hospital in Detroit, Mich- camera view, the surgeon can no longer see inside igan is the first facility in the country to perform the patient directly. Visualization is critical for surgery routinely using a robotic system for the systems that use a robotic interface because the treatment of prostate cancer. With this robotic surgeon typically operates from a remote location laparoscopic procedure, the patient’s pain, blood and relies almost entirely on indirect, limited field- loss, and recovery time in the hospital and at of-view video of the surgery [27,33,34]. Direct home are reduced significantly compared with linkage of medical robotic systems to patient data traditional surgery. In addition, the procedure and the optimal visualization of those data for eliminates the need for large incisions [15]. the surgical team are important for successful operations. In their review article on medical robots, Cleary and Nguyen [27] state that if medical * Corresponding author. robots are to reach their full potential, they need E-mail address: [email protected] to be more integrated systems in which the robots (A. Pandya). are linked to the imaging modalities or directly to 0094-0143/04/$ - see front matter Ó 2004 Elsevier Inc. All rights reserved. doi:10.1016/j.ucl.2004.06.013 794 A. Pandya, G. Auner / Urol Clin N Am 31 (2004) 793–800 the patient anatomy. They state further that robotic arms on the operating table to avoid robotics systems need to be developed in an collisions between arms during the procedure ‘‘Image-Compatible’’ way. Visual information and maximize the range of motion of the instru- from the patient site needs to be augmented to ments. A significant potential exists to affect allow greater situational awareness, accuracy, and medical robotics with the preoperative planning confidence. That is, these systems must operate and intraoperative visualization tools [37]. within the constraints of various image modalities Two types of visualization technology have such as CT and MRI. This link, they conjecture, is been used for real-time visualization in the essential if the potential advantages of robots are medical domain: augmented reality (AR) and to be realized in the medical domain. virtual reality (VR) [38,39]. These visualization In addition, surgical planning and information methods are well suited for robotic surgery. management for these robotic systems is essential Image guidance is an example of VR. In image- for successful operations [27]. Two main problems guidance surgery (IGS), the surgeon views a encountered in robotic surgery are nonoptimal computer-generated world of image data and port (incisions on the patient’s body for the three-dimensional models after registration. The robotic arms) placements and robotic-arm colli- registration ensures a one-to-one correspondence sions. Robotic-arm collisions often require man- to the end-effector of the robot and the image ual repositioning of the robotic arms on the coordinates. In contrast, the AR system gener- operating table that unnecessarily adds to the ates a composite view for the user that includes operative time. Incorrect port placement typically the live video view fused (registered) with either results in robotic-arm collisions, can damage precomputed data (eg, three-dimensional geome- robotic instruments, and also can make the try) or other registered sensed data [40].ARis operative site inaccessible. Improved accessibility a variation and extension of VR and represents to the operative site can enhance patient safety a middle ground between computer graphics in [35]. These problems can be avoided in the a completely synthetically generated world (as in preoperative stages given the appropriate visual- VR) and a normal camera view of the real world ization tools. Therefore, it is important that [41–45]. The current technique of image guidance a robust visualization system be built that is does not allow the surgeon to use real and linked to patient imaging data to offer the surgeon synthetic data simultaneously [46]. The surgeon tools for visualization, robotic system setup, and can detect anomalies using advanced imaging port placement [36]. and sensors and can place his or her tools Computer modeling tools that help visualize accurately within surgical environments with the anatomic structures of the patient would aid robots. Nevertheless, the surgeon also needs his the surgeon greatly in the preoperative stage. or her own vision to detect other features that Visualization tools can help the surgeon determine may not be available from the sensor informa- optimal port-placement sites. In addition, these tion. This, the authors believe, is one advantage tools will help determine the placement of the of AR (Fig. 1) [47]. Fig. 1. Augmented reality and image-guided visualization. A. Pandya, G. Auner / Urol Clin N Am 31 (2004) 793–800 795 Robotic ultrasound volume. If this information is extracted, the physical parameters of each resolvable volume Imagine listening to tissue for abnormalities. element (ie, approximately 1 mm3) in the insoni- New technology using acoustic holography is fied volume then should enable diagnosis of the within reach for early diagnosis of diseases such nature of the material. In principle, it is possible as cancer because of significant advances in to distinguish small tumors from healthy tissues microsystem and signal analysis. Although holog- by this method. Preliminary images and phase raphy technology has existed for over 25 years, its information are shown in Fig. 2. application in the clinical/diagnostic arena did not come to fruition because of a lack of advanced microsystems and signal analysis technology. Robotic touch What has been missing is a conversion element that can record the ultrasound interference pat- Can the sense of hyper-touch and -temperature terns, reconstruct them with a real or synthesized be useful for a surgeon? Development of advanced ultrasound interference pattern, and finally re- force-sensing arrays can advance tactile augmen- construct them with real or synthesized ultra- tation on the robot. For example, new dual-mode sound frequency waves that could be transformed acoustic wave sensors that can switch between directly into a visible image. surface acoustic wave and surface transverse wave This is now possible using micropiezoelectric modes can sense pressure and viscosity in liquid, arrays equipped with chip reconstruction at high distinguish force caused by liquid or solid inter- spatial and temporal resolution. In addition to actions, and further distinguish between normal three-dimensional holography imaging, a vital and transverse forces (pinching pressure or sliding objective of the device is to recover the wave frictional forces). Because new wide-bandgap, envelope emerging from each pixel. Although the semiconductor-based acoustic sensor arrays have hologram requires freezing the waves in time long linear temperature coefficients, they can be superb enough to capture a stable interference pattern temperature sensors as well. Thus, tactile forces with adequate signal-to-noise (typically
Recommended publications
  • Gene Therapy and Genetic Engineering: Frankenstein Is Still a Myth, but It Should Be Reread Periodically
    Indiana Law Journal Volume 48 Issue 4 Article 2 Summer 1973 Gene Therapy and Genetic Engineering: Frankenstein is Still a Myth, but it Should be Reread Periodically George A. Hudock Indiana University - Bloomington Follow this and additional works at: https://www.repository.law.indiana.edu/ilj Part of the Genetics and Genomics Commons Recommended Citation Hudock, George A. (1973) "Gene Therapy and Genetic Engineering: Frankenstein is Still a Myth, but it Should be Reread Periodically," Indiana Law Journal: Vol. 48 : Iss. 4 , Article 2. Available at: https://www.repository.law.indiana.edu/ilj/vol48/iss4/2 This Article is brought to you for free and open access by the Law School Journals at Digital Repository @ Maurer Law. It has been accepted for inclusion in Indiana Law Journal by an authorized editor of Digital Repository @ Maurer Law. For more information, please contact [email protected]. GENE THERAPY AND GENETIC ENGINEERING: FRANKENSTEIN IS STILL A MYTH, BUT IT SHOULD BE REREAD PERIODICALLY GEORGE A. HUDOCKt Biotechnology and the law are far removed from each other as disciplines of human intellect. Yet the law and my own discipline, genetics, have come together in many courtrooms concerning such matters as paternity, and they will continue to intersect with increasing frequency as the visions of 100 years ago become the reality of today. This article examines the implications of recent research for human genetic therapy and genetic engineering, and suggests some guidelines for legal regulation of genetic technology. The following discussion derives from three premises which I view as basic: (1) that which is currently possible in genetic engineering, and in fact has already been done, is generally underestimated; (2) what may be possible in the near future is quite commonly overesti- mated; (3) regulation of the application of genetic technology is possible and will not be overwhelmingly complicated.
    [Show full text]
  • New Techniques of Genetic Engineering
    March 2016 New techniques of genetic engineering Why EU GMO law must be fully applied to the so-called ‘New Plant Breeding Techniques’ The European Commission is considering whether genetically modified organisms (GMOs) that have been produced through a range of new techniques should be excluded from the European Union’s GMO regulations. Biotechnology companies want to apply these techniques to engineer plants and animals for use in industrial food, biomass and biofuel production. They argue that these new methods to directly modify the genetic make-up of living organisms fall outside the scope of EU GMO regulations. This would mean that there is no risk assessment, labelling and monitoring of GM organisms produced by the new techniques and their derived products. The Commission has announced that it will present a legal analysis on the matter by the end of March 2016. The new GMOs present a real risk to the environment and human health. Legal analysis shows that they are covered by EU GMO law. If they were to escape EU regulations, any potential negative effects on food, feed or environmental safety would go unchecked. European consumers, farmers and breeders would have no way to avoid GMOs. The Commission should leave no doubt that all products of genetic engineering are subject to EU GMO law which requires rigorous risk assessment, detectability and labelling. 1 Which techniques are we talking about? The biotechnology industry and the European Commission use the term ‘New Plant Breeding Techniques’ to refer to a diverse set of genetic
    [Show full text]
  • Drawing the Line: Disability, Genetic Intervention and Bioethics
    laws Article Drawing the Line: Disability, Genetic Intervention and Bioethics Adam Conti Graduate student, Melbourne Law School, University of Melbourne, 185 Pelham St., Carlton, VIC 3053, Australia; [email protected] Received: 2 June 2017; Accepted: 10 July 2017; Published: 17 July 2017 Abstract: Meteoric scientific advances in genetic technologies with the potential for human gene editing intervention pose tremendous legal, medical, social, ethical and moral issues for society as a whole. Persons with disabilities in particular have a significant stake in determining how these technologies are governed at the international, domestic and individual levels in the future. However, the law cannot easily keep up with the rate of scientific progression. This paper aims to posit a methodology of reform, based on a core value of human dignity, as the optimal course of action to ensure that the interests of persons with disabilities, other possibly marginalised groups, and the scientific community, are balanced fairly. The paper critically analyses the current law and varying bioethical perspectives to ultimately conclude that a clear principled approach toward open discussion and consensus is of paramount importance to have any chance of devising an effective regulatory regime over human gene editing technology. Keywords: disability; human rights; genetics; gene editing; bioethics; governance; human dignity; eugenics; germline; Convention on the Rights of Persons with Disabilities The true good is in the different, not the same (Menand 2004). 1. Introduction Popular, professional and scholarly interest in genetics and their influence on human variability, behaviour and development has grown exponentially in recent years. In no small part has this interest been bolstered by mainstream media coverage of large-scale collaborative scientific initiatives like the Human Genome Project, which endeavoured to identify and map the human genome and determine the sequence of nucleotide base pairs that make up our DNA.
    [Show full text]
  • Genetic Engineering & Genetically Modified Organisms
    Genetic Engineering & Genetically Modified Organisms: Forming Informed Opinions By Smith, Lisa Scientific Theme(s): Science and Technology *Relationships among science, technology, and society Grade Level(s): 6-8 Lesson Duration: Designed for one 70 minute lesson Overview This lesson provides students an introduction to genetic engineering and genetically modified organisms, and raises student awareness of the potential Bias of availaBle information and the importance of forming informed, defendaBle opinions regarding controversial topics in science. The lesson was designed as an introduction for students to the genetic engineering and genetically modified organisms in preparation for a two-week research project exploring GMO topics, culminating with student presentations giving their opinions on the topics. Objectives Students will: 1. Define the term, ‘Biotechnology’. 2. Understand the difference Between selective Breeding and genetic engineering. 3. Identify different applications of genetic engineering, and recognize that all genetically engineered organisms are genetically modified organisms (GMOs). 4. Recognize Bias in print media, and to Be aware of the need to identify sources. 5. Understand the importance of forming informed, defendaBle opinions. Grade Level Expectations (GLEs) Addressed Science as Inquiry and Process [7] SA2.1 identifying and evaluating the sources used to support scientific statements Science and Technology [7] SE1.1 descriBing how puBlic policy affects the student’s life (e.g., puBlic waste disposal) [7] SE3.1 recognizing the effects of a past scientific discovery, invention, or scientific Breakthrough (e.g., DDT, internal comBustion engine) Required BacKground This lesson builds upon concepts covered in previous lessons on DNA, genes, and heredity. Students should have a solid understanding of the Basics of these concepts, including the idea that DNA is the “Blueprint” of life, that genes are coding regions of DNA, and that traits encoded By genes can Be inherited.
    [Show full text]
  • Genetic Engineering (3500 Words)
    Genetic Engineering (3500 words) Biology Also known as: biotechnology, gene splicing, recombinant DNA technology Anatomy or system affected: All Specialties and related fields: Alternative medicine, biochemistry, biotechnology, dermatology, embryology, ethics, forensic medicine, genetics, pharmacology, preventive medicine Definition: Genetic engineering, recombinant DNA technology and biotechnology – the buzz words you may have heard often on radio or TV, or read about in featured articles in newspapers or popular magazines. It is a set of techniques that are used to achieve one or more of three goals: to reveal the complex processes of how genes are inherited and expressed, to provide better understanding and effective treatment for various diseases, (particularly genetic disorders) and to generate economic benefits which include improved plants and animals for agriculture, and efficient production of valuable biopharmaceuticals. The characteristics of genetic engineering possess both vast promise and potential threat to human kind. It is an understatement to say that genetic engineering will revolutionize the medicine and agriculture in the 21st future. As this technology unleashes its power to impact our daily life, it will also bring challenges to our ethical system and religious beliefs. Key terms: GENETIC ENGINEERING: the collection of a wide array of techniques that alter the genetic constitution of cells or individuals by selective removal, insertion, or modification of individual genes or gene sets GENE CLONING: the development
    [Show full text]
  • The Moral Dilemma of Genetically Modified Foods (Gmos)
    Fordham University Masthead Logo DigitalResearch@Fordham Student Theses 2001-2013 Environmental Studies 2005 The orM al Dilemma of Genetically Modified Foods (GMOs) Anamarie Beluch Follow this and additional works at: https://fordham.bepress.com/environ_theses Part of the Environmental Sciences Commons Recommended Citation Beluch, Anamarie, "The orM al Dilemma of Genetically Modified Foods (GMOs)" (2005). Student Theses 2001-2013. 72. https://fordham.bepress.com/environ_theses/72 This is brought to you for free and open access by the Environmental Studies at DigitalResearch@Fordham. It has been accepted for inclusion in Student Theses 2001-2013 by an authorized administrator of DigitalResearch@Fordham. For more information, please contact [email protected]. The Moral Dilemma of Genetically Modified Foods (GMOs) By Anamarie Beluch Genetically modified (GM) foods are foods that are produced from genetically modified organisms (GMO) that have had their DNA altered through genetic engineering. The process of producing a GMO used for genetically modified foods involve taking DNA from one organism, modifying it in a laboratory, and then inserting it into the target organism's genome to produce new and useful genotypes or phenotypes. These techniques are generally known as recombinant DNA technology. In recombinant DNA technology, DNA molecules from different sources are combined in vitro into one molecule to create a new gene. This DNA is then transferred into an organism and causes the expression of modified or novel traits. Such GMOs are generally referred to as transgenic, which means pertaining to or containing a gene or genes from another species. There are other methods of producing a GMO, which include increasing or decreasing the number of copies of a gene already present in the target organism, silencing or removing a particular gene, or modifying the position of a gene within the genome.
    [Show full text]
  • Human Gene Therapy: Ethics and Public Policy*
    HUMAN G E N E T H E R A P Y 2:115-122 (1991) Mary A n n Liebert, Inc., Publishers Human Gene Therapy: Ethics and Public Policy* LEROY W A L T E R S ABSTRACT The first t h r e e h u m a n gene t r a n s f e r / t h e r a p y clinical p r o t o c o l s a r e n o w u n d e r w a y after h a v i n g b e e n s u b j e c t e d t o a n extensive review process b y t h e Recombinant D N A A d v i s o r y Committee (RAC) a n d i t s H u m a n Gene Therapy S u b c o m m i t t e e . T h e "Points t o C o n s i d e r " d o c u m e n t d e v e l o p e d b y t h e R A C established t h e f r a m e w o r k for e v a l u a t i n g genetic i n t e r v e n t i o n protocols. T h i s r e v i e w process is t a k i n g place in a b r o a d e r social c o n t e x t .
    [Show full text]
  • Science of Genetically Engineered Crops (AKA Gmos)
    Science of Genetically Engineered Crops (AKA GMOs) Margaret Smith Plant Breeding & Genetics Cornell University Topics • What is a “GMO”? • How is genetic engineering done? • Where are products from GE varieties found in our food and feed systems? What is a “GMO”? • It depends on who you ask! • Genetically modified organism – Organism = a plant, animal, or microbe – Foods are not organisms, thus not “GMO” – Food products or ingredients might come from a GMO • What is considered “genetically modified”? 2016 US Labeling Act • “Bioengineering” refers to a food: – “That contains genetic material that has been modified through in vitro recombinant DNA techniques; and – For which the modification could not otherwise be obtained through conventional breeding or found in nature.” UN FAO / WHO Definition “Genetically engineered/modified organisms, and products thereof, are produced through techniques in which the genetic material has been altered in a way that does not occur naturally by mating and/or natural recombination.” Which are “natural”? • Domestication • Farmer selection of new crops and varieties • Cross breeding • Genetic engineering Techniques that produce “GMO” varieties • Genetic engineering Techniques that produce “GMO” varieties • Genetic engineering • Cell or protoplast fusion? Techniques that produce “GMO” varieties • Genetic engineering • Cell or protoplast fusion? • Gene editing? Techniques that produce “GMO” varieties • Genetic engineering • Cell or protoplast fusion? • Gene editing? • Gene drives? Am I eating foods from genetically engineered crops? What foods contain GE crops? • 60-70% of supermarket foods have ingredients from a GE variety • Products made with soy or corn most obvious • Products with soy or corn derivatives • Limited fresh produce Food for Thought * * * * * * * * * * * * * * * * * * Ingredient may be made from a genetically-engineered organism The Food Supply GE Crops Non-GE Crops Harvesting Detection Equip.
    [Show full text]
  • De-Extinction in a Crisis Discipline C
    opinions, perspectives & reviews ISSN 1948-6596 opinion De-extinction in a crisis discipline C. Josh Donlan Advanced Conservation Strategies, Midway, UT 84049 USA & Department of Ecology & Evolutionary Bi- ology, Cornell University, Ithaca, NY 14853 USA. [email protected] De-extinction, the idea of resurrecting extinct spe- one of hundreds of technological innovations that cies using genetic engineering, has recently caught will happen in the coming decades. Most of them the attention of both the scientific community and will bring new ethical challenges, and de- the wider public (Kumar 2012, Sherkow and extinction may prove to be mild compared to Greely 2013, Zimmer 2013). A diverse group of other disruptive innovations coming our way. The scientists and practitioners, led by long-time envi- pace of de-extinction progress will largely depend ronmental proponent Stewart Brand, has been on the resources its proponents are able to at- busy articulating a framework for de-extinction tract. and exploring a roadmap forward, including iden- Like all intervention-based strategies, there tifying the many challenges that lie ahead. De- will be risks, costs and benefits to de-extinction. In extinction may mean different things to different my view, the potential benefits are profound, people. The Long Now Foundation defines it as while the potential costs and risks are real, but using “genetic technology and DNA from museum not novel. The risks are similar to other restora- specimens or fossils to revive species that have tion-based approaches to biodiversity conserva- gone totally extinct”1. Related discussions are also tion, such as the potential for disease transmis- underway around using genetic engineering to sion and unexpected species interactions (Donlan assist populations in adapting to climate change et al.
    [Show full text]
  • Genetically Modified Organisms Vocabulary Deoxyribonucleic Acid (DNA) Gene - a Section of DNA That - the Long, Double-Stranded Codes for a Specific Product
    A Quick Look at Genetically Modified Organisms Vocabulary Deoxyribonucleic acid (DNA) Gene - a section of DNA that - the long, double-stranded codes for a specific product. helical molecule that contains Genes (and environmental fac- an organism’s genes. tors) determine traits exhibited The “blueprint” or “recipe” for by an organism. an organism. Genetically Modified Transgenic Organism - an Organism (GMO) - an organism organism that has had genes whose DNA has been changed from another species, or syn- in some way. Includes alteration thetic genes, introduced into its by genetic engineering and DNA by genetic engineering. non-genetic engineering meth- Sometimes found in nature, ods. Frequently occur in nature. most created in laboratories. Genetic Engineering - the Mutation - a spontaneous or in- introduction or change of DNA, duced change in an organism’s RNA, or proteins by human DNA. Plant “sports”, like blood manipulation. oranges, are common examples of mutation. Methods Used in Plant Breeding Conventional Breeding Genetic Engineering Cross Pollination Agrobacterium-mediated The natural or artificial Transformation transfer of pollen from one The use of the naturally sexually compatible part- occurring, soil-dwelling ner to another. The oldest bacterium Agrobacterium technique used in plant tumefaciens to transfer breeding. genes into a target plant. Chromosome Doubling Gene Editing Inhibiting proper cell divi- The use of sequence-specific sion to produce cells with enzymes to alter targeted, twice the amount of DNA. non-random sites in the Can be induced by radia- DNA. Allows for precision tion, chemical treatment, or genetic engineering. natural errors in cell division. Mutation Breeding Particle Bombardment The process of exposing “Gene gun” method.
    [Show full text]
  • Molecular Technology the Promise Of
    The Promise of Molecular Technology Unlocking new sources of molecular diversity to create products that are better, cheaper and more sustainable for all TABLE OF CONTENTS 03 Overview - About Zymergen 05 The Zymergen Approach 09 The Science and Technology to Make the Promise a Reality 15 Market Impact and Opportunities ABOUT ZYMERGEN ABOUT ZYMERGEN Over the past century, industrial progress has not kept pace drive untargeted, genome-wide surveys to discover unknown with the demands of the world. For decades, the materials used in traits. Our software infrastructure lays on top of our cutting- everything from clothing to toothpaste, food sweeteners, fertilizers, edge manufacturing environment, an automated, modular, full- and many other products have been obtained from petroleum. production facility for creating modified microbial strains. In this People have now nearly exhausted the methods for using facility, scientists safely and accurately conduct high throughput petrochemicals and traditional processes to create wholly new (HTP) experiments using automated equipment and workflows. materials. Yet, innovation relies on creating products that are high- Zymergen’s proprietary manufacturing platform and data performance and sustainably-sourced. Zymergen looks to biology infrastructure enable work with a wide range of microbes in a host to produce these new molecules that will make up the materials of agnostic manner. We have proven capabilities with the full range the future. of microbes currently used for industrial production, including Founded in 2013, Zymergen marries the latest innovations in canonical hosts such as S. cerevisiae and E. coli, as well as a range data science, automation, and molecular biology to discover and of yeasts and filamentous fungi, and less commonly engineered engineer new molecular products.
    [Show full text]
  • How Genetic Engineering Differs from Conventional Breeding Hybridization
    GENETIC ENGINEERING IS NOT AN EXTENSION OF CONVENTIONAL PLANT BREEDING; How genetic engineering differs from conventional breeding, hybridization, wide crosses and horizontal gene transfer by Michael K. Hansen, Ph.D. Research Associate Consumer Policy Institute/Consumers Union January, 2000 Genetic engineering is not just an extension of conventional breeding. In fact, it differs profoundly. As a general rule, conventional breeding develops new plant varieties by the process of selection, and seeks to achieve expression of genetic material which is already present within a species. (There are exceptions, which include species hybridization, wide crosses and horizontal gene transfer, but they are limited, and do not change the overall conclusion, as discussed later.) Conventional breeding employs processes that occur in nature, such as sexual and asexual reproduction. The product of conventional breeding emphasizes certain characteristics. However these characteristics are not new for the species. The characteristics have been present for millenia within the genetic potential of the species. Genetic engineering works primarily through insertion of genetic material, although gene insertion must also be followed up by selection. This insertion process does not occur in nature. A gene “gun”, a bacterial “truck” or a chemical or electrical treatment inserts the genetic material into the host plant cell and then, with the help of genetic elements in the construct, this genetic material inserts itself into the chromosomes of the host plant. Engineers must also insert a “promoter” gene from a virus as part of the package, to make the inserted gene express itself. This process alone, involving a gene gun or a comparable technique, and a promoter, is profoundly different from conventional breeding, even if the primary goal is only to insert genetic material from the same species.
    [Show full text]