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Monitoramento Em Biotecnologia

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Monitoramento Em Biotecnologia MONITORAMENTO EM BIOTECNOLOGIA Desenvolvimento científico e tecnológico Executor: Sistema de Informação sobre a Indústria Química (SIQUIM) / Escola de Química (EQ) / Universidade Federal do Rio de Janeiro (UFRJ) Dezembro / 2004 EQUIPE: Coordenação Geral: Profª Dra. Adelaide Antunes Coordenação Técnica: Dra. Claudia Canongia Pesquisadores: Simone Alencar – Engenheira Química, Doutoranda EQ/UFRJ Andressa Gusmão – Estagiária, Escola de Química EQ/UFRJ Daniel Hoefle - Estagiário, Escola de Química EQ/UFRJ Fernando Tibau – Estagiário, Escola de Química EQ/UFRJ Max Arnor – Estagiário, Ciências Atuariais IM/UFRJ SUMÁRIO 1 INTRODUÇÃO .................................................................................................................................................... 1 2 METODOLOGIA ................................................................................................................................................. 2 3 TENDÊNCIAS DE DESENVOLVIMENTO CIENTÍFICO (ARTIGOS) EM BIOTECNOLOGIA ........................... 5 3.1 TEMA: BIODIVERSIDADE/BIOPROSPECÇÃO .................................................................................................... 5 3.2 TEMA: BIOECONOMIA................................................................................................................................. 21 3.3 TEMA: BIOINDÚSTRIA ................................................................................................................................. 26 3.4 TEMA: BIOINFORMÁTICA............................................................................................................................. 34 3.5 TEMA: BIORREMEDIAÇÃO ........................................................................................................................... 40 3.6 TEMA: BIOTERRORISMO ............................................................................................................................. 46 3.7 TEMA: CERTIFICAÇÃO DE QUALIDADE BIOLÓGICA ......................................................................................... 50 3.8 TEMA: DEFESA AGROPECUÁRIA ................................................................................................................. 50 3.9 TEMA: FARMACOGENÉTICA ........................................................................................................................ 58 3.10 TEMA: FERTILIDADE E REPRODUÇÃO ANIMAL ............................................................................................... 62 3.11 TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE .............................................................................. 65 3.12 TEMA: METAGENÔMICA/ PROSPECÇÃO GÊNICA........................................................................................... 78 3.13 TEMA: MUDANÇAS CLIMÁTICAS GLOBAIS ..................................................................................................... 81 3.14 TEMA: PROGRAMAS DE DESCOBERTA......................................................................................................... 84 3.15 TEMA: SEGURANÇA BIOLÓGICA ................................................................................................................ 106 3.16 TEMA: SUSTENTABILIDADE AMBIENTAL ..................................................................................................... 111 4 TENDÊNCIAS DE DESENVOLVIMENTO TECNOLÓGICO (PATENTES) EM BIOTECNOLOGIA.............. 121 4.1 TEMA: BIODIVERSIDADE / BIOPROSPECÇÃO............................................................................................... 121 4.2 TEMA: BIOECONOMIA............................................................................................................................... 130 4.3 TEMA: BIOINDÚSTRIA ............................................................................................................................... 133 4.4 TEMA: BIOINFORMÁTICA........................................................................................................................... 151 4.5 TEMA: BIORREMEDIAÇÃO ......................................................................................................................... 156 4.6 TEMA: BIOTERRORISMO ........................................................................................................................... 167 4.7 TEMA: CERTIFICAÇÃO DE QUALIDADE BIOLÓGICA ....................................................................................... 170 4.8 TEMA: DEFESA AGROPECUÁRIA ............................................................................................................... 173 4.9 TEMA: FARMACOGENÉTICA ...................................................................................................................... 181 4.10 TEMA: FERTILIDADE E REPRODUÇÃO ANIMAL ............................................................................................ 184 4.11 TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE............................................................................ 187 4.12 TEMA: METAGENÔMICA / PROSPECÇÃO GÊNICA........................................................................................ 208 4.13 TEMA: MUDANÇAS CLIMÁTICAS GLOBAIS ................................................................................................... 209 4.14 TEMA: PROGRAMAS DE DESCOBERTA....................................................................................................... 210 4.15 TEMA: SEGURANÇA BIOLÓGICA ................................................................................................................ 255 4.16 TEMA: SUSTENTABILIDADE AMBIENTAL ..................................................................................................... 258 1 1 Introdução A área de biotecnologia vem sendo reforçada mundialmente como tecnologia portadora de futuro com importante papel em vários setores dentre eles Saúde, Agricultura, Informática e Meio Ambiente. O monitoramento nesta área é, portanto, essencial para identificação de tendências e lideranças. Assim, este trabalho tem como objetivo realizar monitoramento visando a identificação de tendências de desenvolvimento científico e tecnológico de produtos e serviços decorrentes da Biotecnologia, nos últimos 10 anos (1994/2004), em nível internacional e nacional. Este primeiro relatório apresenta visão de desenvolvimento científico (artigos) e tecnológico (patentes) considerando freqüência e série histórica dos temas e termos demandados, pertinentes a artigos e patentes, acrescentando-se lista com até 100 títulos mais recentes como amostragem para apoio à decisão e priorização. Monitoramento em Biotecnologia SIQUIM/EQ/UFRJ e CGEE 2 2 Metodologia As pesquisas foram realizadas a partir dos temas e termos propostos pelos especialistas em biotecnologia e entregue pelo Prof. Sérgio Salles (UNICAMP) representando o CGEE, apresentados na tabela a seguir, em que foram salientados em negrito os prioritários para o primeiro relatório. Tabela - Termos de busca para monitoramento em biotecnologia BIOTECNOLOGIA TEMAS TERMOS Bancos de germoplasma Herbários e demais formas de conservação ex situ Legislação ágil e eficiente Plantas/Animais e Microbiota 1. Biodiversidade/ Biodiversidade marinha Bioprospecção Acesso ao patrimônio Genético Conhecimento tradicional Mercado de produtos da floresta Propriedade intelectual Fitomedicamentos Mercado Nacional e Internacional Patentes Cadeia produtiva 2. Bioeconomia Inovação tecnológica Projetos pré-competitivos Produtos orgânicos Cadeia produtiva Produtos pré-competitivos Valor agregado Bioprodutos 3. Bioindústria Produtos com alta, média e baixa incorporação de (bio)tecnologia Marketing de Biotecnologia Branding Designing Redes Software 4. Bioinformática Gestão do conhecimento Aplicações para Genomas, proteomas e biodiversidade Meio ambiente Indústrias com passivo 5. Biorremediação ambiental alto Microorganismos Legislação 6. Bioterrorismo Capacitação de pessoal Inteligência Coleções certificadas 7. Certificação de qualidade Qualidade industrial biológica Microorganismos Fertilidade e 8. Competitividade da Reprodução Animal Economia Nacional Monitoramento em Biotecnologia SIQUIM/EQ/UFRJ e CGEE 3 BIOTECNOLOGIA TEMAS TERMOS Controle de pragas Espécies invasoras Normas internacionais Infra-estrutura para biossegurança Normas de qualidade 9. Defesa Agropecuária Capacidade Antecipativa Leitura de Cenários Capacidade de Integração de Orgãos e Arcabouços Legais Sistemas Efetivos de Monitoramento Recursos Humanos Fármacos Fitomedicamentos 10. Farmacogenética Custo/benefício Genoma de populações Melhoria genômica Competitividade 11. Fertilidade e reprodução Clonagem animal Células tronco Novos fármacos Capital de risco Eficiência das agências públicas 12. Financiamento Formas ágeis de avaliação Capitalização das empresas Espaço para micro-empresas Bancos de dados Propriedade da informação 13. Gestão de Informação Pessoal qualificado Biológica Desenvolvimento de software Integração de Sistemas Redes Cooperativas Nutracêuticos (Alimentos Funcionais) Novas formulações Alimentos especiais para populações especiais Qualidade de vida 14. Integração: alimentação, Bem estar nutrição e saúde Produtos orgânicos Organismos Geneticamente Modificados Produção de Vacinas em Plantas e Animais Produção de Hormônios Informação 15. Inteligência Quarentenária Espécies invasoras Qualidade agropecuária Ver Biodiversidade/ 16. Metagenômica/ Prospecção Bioprospecção Gênica Remediação ambiental Monitoramento Mudanças nos padrões de produção
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