Day of Immunology 2018 P12

ASI NEWS JUNE 2018

DAY OF IMMUNOLOGY 2018 P12

Australasian Society 14 23 for Immunology Inc.

IN MEMORY OF THE INAUGURAL WOMEN’S ASI Inc. Secretariat DEREK HART: DENDRITIC INITIATIVE AWARD PO Box 1371, Mitcham North 3132 Dr. Hamutal Mazrier Ph: 03 8393 9388 CELL PIONEER http://www.immunology.org.au/contact-us/ Mark Hogarth, Georgina Clark & Dr. Cindy Ma & Barbara Fazekas ASI NEWSLETTER JUNE 2018

CONTENTS

HELLO FROM THE EDITOR! ...... 5 Day of Immunology Public Forum: Immunology education is the Immunotherapy and Cancer, 3 perspectives new Translational Medicine Tessa Campbell and Caroline Ashley ...... 26 Angelica Lau DAY OF IMMUNOLOGY IN QLD ...... 28 PRESIDENT’S REPORT ...... 6 Sumaira Hasnain, QLD Councillor Susanne Heinzel, ASI president DAY OF IMMUNOLOGY IN SA AND NT ...... 30 FROM THE OUTGOING ASI SECRETARIAT ...... 8 Iain Comerford, SA/NT Councillor Judi Anderson DAY OF IMMUNOLOGY IN NZ ...... 32 47TH ANNUAL SCIENTIFIC MEETING Dr. Emily Bisset 2ND-6TH DECEMBER 2018, PERTH WA ...... 11 2017 GORDON ADA Connie Jackaman and Scott Fisher, SENIOR AWARD WINNER ...... 33 ASI2018 Co-Chair Dr. Connie Wong, Monash University THE IUIS CORNER ...... 12 JARED PURTON AWARD RECIPIENT 2016 ....35 J. Alejandro Lopez Sumaira Hasnain IN MEMORY OF DEREK HART: ASI’S VISITING SPEAKER PROGRAM ...... 37 DENDRITIC CELL PIONEER ...... 14 Stuart Mannering, VSP Coordinator Mark Hogarth, Georgina Clark and Barbara Fazekas BRANCH REPORTS ...... 38

DAY OF IMMUNOLOGY 2018 ...... 16 WOMEN’S INITIATIVE AWARD RECIPIENTS 46 Dr Gabriella Khoury TRAVEL REPORTS ...... 48

DAY OF IMMUNOLOGY IN VIC ...... 20 PUBLICATIONS OF INTEREST ...... 54 Dr. Kim Pham Our Sustaining Members

DAY OF IMMUNOLOGY IN NSW ...... 22 ABOUT THE AUSTRALASIAN SOCIETY Day of Immunology Discovery Tours FOR IMMUNOLOGY ...... 57 at the Garvan Institute Angelica Lau and Joanne Reed ...... 22

DoI at the Museum of Human Disease, UNSW Fabio Luciani, UNSW ...... 24 FRONT COVER: DAY OF IMMUNOLOGY FLASH MOB

8 16 50 JUDI ANDERSON DAY OF IMMUNOLOGY SAN SERVOLO ISLAND A few words from the 19th International outgoing ASI Secretariat logo competition for Conference on Lymphatic The International Day of Tissues and Germinal Immunology 2018. Centres in Immune Reactions

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SECRETARY’S REPORT ASI NEWSLETTER MARCH 2018 Clinical & Translational Immunology

Cutting-edge advances in biomedical research Editor-in-Chief: Rajiv Khanna Clinical & Translational Clinical & Translational Immunology is an Immunology open access, online-only journal, seeking www.wileyonlinelibrary.com/journal/cti Volume 7‚ Issue 1‚ January 2018 to cover basic, translational and clinical studies in all aspects of human immunology, including experimental models specific to human diseases.

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Find out more at www.wileyonlinelibrary.com/journal/cti EDITORIAL ASI NEWSLETTER JUNE 2018

HELLO FROM THE EDITOR! Immunology education is the new Translational Medicine ANGELICA LAU

It wasn’t that long ago the ASI quarterly newsletter was published in March – yet this June edition is more exciting than ever!!

Many events have happened engage and educate the public within these few short months, (kids and parents alike) about Be sure to check out how ranging from prominent visiting the progress of translational different states celebrated and speakers gracing our southern Immunology research during the showcased their passion for continent and sharing with us their week of DoI. With the increasing Immunology research! research, to the hugely successful application of immunotherapies celebration of International Day and personalised medicines, of Immunology (DoI) across the public engagement and education On a more solemn note, in this Australasian region. It is pleasing about the importance of targeting issue we also take the chance to to hear from president Su Heinzel and manipulating the immune honour an invaluable ASI member, that ASI aim to collaborate more system have never been more the late Derek Hart (1952-2017), with its sister society ASCIA, and important. The enthusiasm from pioneer of dendritic cell research. ASI members are encouraged all the volunteers who helped Thanks to Mark Hogarth, Georgina and invited to their society organise and run the DoI events Clark and Barbara Fazekas who meetings. Clearly there are many really highlighted how active and wrote this obituary – a remarkable new incentives and initiatives translatable Immunology research story of a pioneer with an happening in all states so make is in Australia and New Zealand. incredible vision who inspired sure to pay attention to your State It really is a perfect opportunity many. Councillor’s reports! for Immunology to shine as a discipline in both basic and clinical If you have anything interesting to If you like some light reading, you research – be sure to check out share with the ASI community, I’d might just like this issue as much love to hear it. as I do. It was great to see our and showcased their passion for ASI members getting creative E: [email protected] Immunology research! with the way they communicate,

Australasian Society for Immunology Inc. PO Box 7108, Upper Ferntree Gully VIC 3156 P: +61 3 9756 0128 E: [email protected]

05 PRESIDENT’S REPORT ASI NEWSLETTER JUNE 2018

PRESIDENT’S REPORT SUSANNE HEINZEL, ASI president

It has been a busy first half of the year for ASI. I firstly want to take this opportunity to welcome the new members to ASI council. Deputy treasurer on their behalf that cannot be Asolina Braun, NSW councillor Helen McGuire, and of course Vice President thanked enough. John Fraser are all members of voting council. Angelica Lau has taken over as Sadly the transition to a new newsletter editor and Stuart Mannering is the new VSP coordinator. secretariat also means the end of an era. Judi Anderson has been There has been a flurry of warmly welcome AES to the world working with ASI for more than activities since they came on of ASI. I also want to encourage 20 years – first as an employee of board and their contributions have membership to actively interact a secretariat service provider and with AES and to address your then as a contractor in her own we’re already half way through the general questions (deadlines, right. She has seen and been part year this is also a timely reminder eligibility, membership etc) to of ASI’s journey. Judi has been that some positions will come to them. Our general e-mail address incredibly loyal and supportive the end of their term (WA, SA/ where queries should be directed of us over the years. Many of you NT and ACT councillors on voting to is: [email protected]. would have had interactions with council, meeting coordinator, As with all changes to systems her over the years and would FIMSA and IUIS councillor as and services, the transition has have experienced her helpfulness non-voting members of council) initially created a lot of extra and diligence first hand. We are at the of the year and that this work. I do want to give a special immensely thankful to her. You is the time to think about good mention to three people. Firstly, can read more about her journey candidates to fill these positions Tyani Chan who is and has with ASI in an article in this and whether this might be the been instrumental in getting newsletter. year where you’d like to put your the transition underway and is hand up and get involved. working closely with all members The biggest change that has of the AES team to transfer the happened within ASI this year has secretariat / admin services. But been the change of our secretariat particularly, I want to mention Kim services from an ‘in house’ service Jacobson and Elissa Deenick who The biggest change that has run by Judi, Sarah and more both have been working tirelessly happened within ASI this year recently Tyani (to fill in for Sarah), during their spare (and sparse) has been the change of our to a professional service company voluntary time to make this AES, headed by Nick Koerbin. The happen. For them the transition secretariat services from an ‘in transition is almost complete and has created a lot of extra work. house’ service. I’d like to take this opportunity to Of course this is only temporary, 6 PRESIDENT’S REPORT ASI NEWSLETTER JUNE 2018

occasions. Over time I assume there will be more and more of these requests and we might consider initiating them ourselves.

The ASI council meets twice a year, mid year and then just before the annual scientiﬁc meeting and I’m writing this just as I come out of the mid year council meeting. Council meetings are always a wonderful way to remind us of the purpose of the society, which is to advance immunology and to support our members. Council is working hard to fulﬁl these goals and I believe that we are on the right track.

As an immediate measure to support our members we have decided to double the funds that go into our travel awards. This means that we now have an ASCIA WA IMMUNOLOGY DAY 2018 - THE WA ASCIA GROUP RAN THE HIGHLY SUCCESSFUL annual budget of $105k to support 8TH ASCIA WA IMMUNOLOGY DAY (WAID) ON 2 JUNE 2018, WITH MORE THAN 70 international travel (Miller, Ada,

BETWEEN ASCIA AND ASI, WITH THE MEETING CHAIRED BY PROFESSOR MICHAELA (ASCIA and ITAs) (equalling >30 members WA CHAIR) AND PRESENTATIONS BY DR WILLIAM SMITH (ASCIA PRESIDENT), DR SUSANNE per year to attend international HEINZEL (ASI PRESIDENT) AND DR CONNIE JACKMAN (ASI WA CHAIR). meetings) and $40k for travel bursaries (around 40-50 students and early career postdocs) We’ve also been focussing on As you may remember we also to attend our own meeting. strengthening our interactions had several requests by societies Discussion on other ways how to with other societies within from other countries to contribute best support our membership are Australia and outside. In particular to their meetings. These requests ongoing (and we’d still love to we are working to build a closer are a wonderful opportunity to hear suggestions about this). relationship with our sister As an exciting new initiative, we society ASCIA. There is a lot of to mid-career scientists. Joshua are on track to provide onsite interaction happening at the Ooi was selected to present at child care facilities during the ASI national and local levels. For the SBI meeting in Brazil. We meeting in Perth. It will be a ﬁrst example, I was privileged to speak were also able to send 5 ASI for us and we are very excited at the local ASCIA meeting in members to the 10th anniversary to see how this works out. The WA last week. There I also had of the Singaporean Society for cost will be partially subsidised the chance to catch up with Immunology. Antje Blumenthal, by ASI and expression of interest the current ASCIA president Emma Hamilton-Williams, Lisa in the facilities is linked to the William Smith and the WA ASCIA Mielke, Scott Mueller and Clare registration page of the meeting. representative Michaela Lucas, Slaney were selected from This will hopefully make it easier who is also a long standing and about 35 expressions of interest for parents to attend our meetings very active ASI member, to talk we received. In return we will and we are hoping it will serve as about ideas to further improve host a group from Singapore at a model for other organisations our collaborations. We are also the 2018 ASI meeting in Perth. too. working on integrating ASCIA The selection of speakers was I’m looking forward to a into our meetings (and vice done in collaboration with productive and positive second versa) and William is a member the hosting societies and led half of the year. of the Adelaide 2019 LOC for that to an outstanding group of purpose. people representing ASI at both

7 DAY OF IMMUNOLOGY REPORTS

THE OUTGOING ASI SECRETARIAT - JUDI ANDERSON ASI NEWSLETTER JUNE 2018

FROM THE OUTGOING ASI SECRETARIAT JUDI ANDERSON

After many years working in advertising and public relations in Melbourne and London, I joined the Victorian Medical Postgraduate Foundation (VMPF) around 1990 as editor of their quarterly magazine and handling general administration where I remained for 10 years. VMPF provided educational services to GPs and overseas doctors seeking registration, as well as providing secretariat services to three organisations. For ASI these services included maintaining of the membership database (new memberships and renewals), preparing and distributing the quarterly newsletter, and basic accounting for ASI income and

expenditures. I didn’t work on JUDI SHOWING KIEWA HER AWARD the ASI account until the last few years of my time with VMPF.

At the end of the 90s, VMPF a dozen staff to 1.5 persons. It the introduction of the GST – a lost its main source of income could not continue to provide headache for all concerned, – funding from the Victorian secretariat services and I was with new procedures and forms government – and went from one of the majority of the staff required. losing their jobs, so I decided Although we had email, most to start my own business, Judi things were still done using The ASI newsletter editor back then Anderson Secretariat Services, printing companies, Australia sourced feature articles, I liaised and continued providing services Post and cheque books – internet to the organisations VMPF had with ITA winners, Branch Councillors banking was still in the future. been looking after. and advertisers, then formatted the The ASI newsletter editor back newsletter before it was printed, Setting up my business then sourced feature articles, I enveloped and mailed out. coincided almost exactly with liaised with ITA winners, Branch 8 DAY OF IMMUNOLOGY REPORTS

THE OUTGOING ASI SECRETARIAT - JUDI ANDERSON ASI NEWSLETTER JUNE 2018

Councillors and advertisers, and general management under then formatted the newsletter the direction of the Council, before it was printed, enveloped including membership application and mailed out. Membership and renewal processes, all linked applications back then required through the website. Payments paper forms signed by two are now by EFT, including nominating members. Renewal overseas payments – no more notices were printed and posted trips to the bank to organise out along with personalised international bank drafts which update forms for members to often caused headaches for bank advise changes to their details. staff when we were reimbursing Renewals were by cheque and Visiting Speakers from all over the credit card, with those processed world. Just a couple of years ago JUDI DRIVING HER PURE BRED MORGAN by handwritten individual the newsletter was completely GELDING, MT TAWONGA KIEWA vouchers posted to members with re-vamped with the editor a receipt. responsible for design, layout and sourcing all materials; it is no Back then, there was no set term years and with the Morgan Horse longer printed and posted – all of office for the newsletter editor Association of Australia since done electronically these days. and at one stage, in the early just after its inception in 1990 2000s, there was an editorial and have been honoured to be committee of four. Some of the I got a ‘kick’ out of seeing ASI awarded Life Membership from editors I worked with in those members (especially those I’d both. I was especially honoured early days were Nicholas King, worked with personally) in the news to receive the 2017 International Miles Davenport, Phil Hodgkin, with breakthroughs in Immunology Award from the American Margaret Cooley, Margaret Baird. Morgan Horse Association for my – though I have to admit I still don’t Photos didn’t become a regular “contribution to the breed”. My part of the newsletter until around understand what you do, even after pure bred gelding, Mt Tawonga 2002. Most of my contact was all this time. Kiewa, is now retired at age 27 with the Honorary Secretary and but has won many awards himself, some of those I worked with were I have seen many changes over including Supreme Morgan Exhibit Jane Allan, Geeta Chaudhri, Jose the 20+ years I have worked for under an American judge at the Villadangos, Susanne Heinzel (the ASI. I’ve had a lot of close working Association’s annual show some current President). I also used to relationships with many newsletter years ago. attend the Mid Year and End of editors, Council members and I have been associated with the Year Council meetings and take Branch Councillors and have VJC’s magazine and am currently Minutes. It wasn’t until 2009 that enjoyed it all very much. I got a its production editor. With the Honorary Secretary took over ‘kick’ out of seeing ASI members the freeing up of my time, I’m these responsibilities, sensible, as (especially those I’d worked with planning to volunteer with the they were involved in day-to-day personally) in the news with Australian Jazz Museum, which decision-making. breakthroughs in Immunology – collects, archives and disseminates though I have to admit I still don’t Technology streamlined Australian jazz. It’s not hard to understand what you do, even procedures and the amount give to ‘causes’ about which you after all this time. of manual handling required are passionate, as is obvious from gradually reduced. Nowadays we Technology has helped me reduce the enthusiasm I have seen with only have one member who pays my working hours and with the those who have participated in by cheque – we’ve moved from a changeover of the Secretariat to ASI activities. majority paying via credit card to Association Executive Services I wish everyone associated with virtually everyone paying through (AES), I will be able to devote ASI all the best for the future and PayPal linked to the online more time to my personal look forward to hearing about database. The move to PayPal passions – traditional jazz (as advances in Immunology which and the online database has a listener, not a musician) and will benefit everyone. occurred over the past five years Morgan horses. I have been or so, along with a ASI member involved with the Victorian Jazz taking on website management Club (VJC) for more than 50

9 Graham Pawelec Kate Schroder SPEAKERS Universityww of Tuebingen,w.asi20 Germany18.org University of Queensland, QLD Fiona Powrie Paul Klenerman Mimi Tang University of Oxford, UK University of Oxford, UK Murdoch Children's Research Institute, VIC Ido Amit Yuval Rinkevich Axel Kallies Weizmann Institute of Science, Israel Helmholtz Zentrum München, Germany Walter and Eliza Hall Institute, VIC Ellen Rothenberg Cecile King Stuart Tangye California Institute of Technology, USA Garvan Institute, NSW Garvan Institute, NSW Andrea Schietinger Sharon Lewin Meredith O’Keeffe Memorial Sloan Kettering, USA University of Melbourne, VIC Monash University, VIC Luke O’Neill Alistair Forrest Ruth Ganss Trinity College Dublin, Ireland Harry Perkins Institute of Medical Research, WA Harry Perkins Institute of Medical Research, WA www.asi2018.org DAY OF IMMUNOLOGY REPORTS

47TH ANNUAL SCIENTIFIC MEETING ASI NEWSLETTER JUNE 2018

47TH ANNUAL SCIENTIFIC MEETING 2ND-6TH DECEMBER 2018, PERTH WA CONNIE JACKAMAN AND SCOTT FISHER, ASI2018 CO-CHAIR

On behalf of the organising Confirmed international speakers areas. December is a great time committee we invite you to join include: Fiona Powrie, Ido to visit and explore the city and Amit, Ellen Rothenberg, Andrea beyond, particularly as there are us for the 47th Annual Scientific Schietinger, Luke O’Neill, Graham cheap airfares on at the moment! Meeting to be held 2nd-6th Pawelec, Paul Klenerman, Yuval We also encourage you to bring December 2018 at Pan Pacific Perth, Rinkevich, Florent Ginhoux, Bing your family, for the first time Western Australia. We are putting Su, Daniela Frasca, Lai Guan Ng childcare facilities will be hosted together in exciting program with and Nicholas Gascoigne. on site. We look forward to seeing you there!. key dates below: This year we will also be Abstracts Open: incorporating an ‘amazing Please visit the website for more Monday 2nd July 2018 race’ into the exhibition booths details: www.asi2018.org whereby you will have the Abstracts Close: opportunity to ‘perform an Friday 31st August 2018 experiment’ by racing through the Registration fees for members: different booths. We also encourage you to $650 early bird member Perth has seen an amazing bring your family, for the first (or $750 after) expansion in the last five years time childcare facilities will be $395 early bird student member with an array of small bars, hosted on site. (or $475 after) restaurants, shopping and cultural

Graham Pawelec Kate Schroder SPEAKERS Universityww of Tuebingen,w.asi20 Germany18.org University of Queensland, QLD Fiona Powrie Paul Klenerman Mimi Tang University of Oxford, UK University of Oxford, UK Murdoch Children's Research Institute, VIC Ido Amit Yuval Rinkevich Axel Kallies Weizmann Institute of Science, Israel Helmholtz Zentrum München, Germany Walter and Eliza Hall Institute, VIC Ellen Rothenberg Cecile King Stuart Tangye California Institute of Technology, USA Garvan Institute, NSW Garvan Institute, NSW Andrea Schietinger Sharon Lewin Meredith O’Keeffe Memorial Sloan Kettering, USA University of Melbourne, VIC Monash University, VIC Luke O’Neill Alistair Forrest Ruth Ganss Trinity College Dublin, Ireland Harry Perkins Institute of Medical Research, WA Harry Perkins Institute of Medical Research, WA www.asi2018.org 11 DAY OF IMMUNOLOGY REPORTS

THE IUIS CORNER ASI NEWSLETTER JUNE 2018

THE IUIS CORNER J. ALEJANDRO LOPEZ

Here is a brief update of the news coming from IUIS. If you wish to follow the news coming directly from the IUIS, visit the www. iuisonline.org.

Secretary-General of the IUIS, an ambassador and has contributed increasing number of members of with the educational video the ASI are also making important “Immunology in 333 seconds” contributions to the work at the (https://www.immunopaedia.org. IUIS. za/our-ambassadors/oceania/). This IUIS website is undergoing a Stuart Tangye from the Garvan There are multiple opportunities substantial restructuring with the recently started his tenure as to contribute and learn from aim at making it more prominent Chair of the Inborn Errors of colleagues around the world at the in the educational resources that Immunity (IEI) committee. same time as you may be earning it has to offer. It is expected to those precious professional launch in early 2019. Di Yu from ANU was elected as contribution points enhancing new member of the Publications You can now also follow IUIS your career development profile. committee, reinforcing the activities on Twitter: https:// presence of the FIMSA countries. twitter.com/iuis_online This followed a call open to all FRONTIERS IN IMMUNOLOGY ASI membership and with the The official journal of the IUIS IUIS NEWSLETTER participation of 9 candidates. has increased its impact factor The latest issue of the IUIS to 6.429, which is fantastic. It Natkunam Ketheesan from the newsletter is available from this currently boasts of being the University of New England is link: https://mailchi.mp/kit-group/ largest and most cited open- now one of the Immunopaedia iuis-online-and-around-the- access journal. world-1081893 IUIS COUNCIL MEETINGS The last council meeting took place in Cancun on May 14-18, in the context of the meeting of the Latin American Congress of Immunology. Australia was represented by Ros Kemp (IUIS General Secretary) and Menno van Zelm from Monash who was chairing the Nomenclature group meeting. MORE ASI MEMBERS CONTRIBUTING TO KEY IUIS ACTIVITIES In addition to the very important job of Roslyn Kemp from IUIS-FAIS-SMI MOROCCO COURSE University of Otago as Executive

12 THE IUIS CORNER ASI NEWSLETTER JUNE 2018

The official journal of the IUIS has • IUIS-FAIS Immuno-Kenya • Award for the Best Newcomer increased its impact factor to 6.429, Course on “How viruses hijack Campaign, by EFIS – 1000 which is fantastic. host immunity leading to euros for the best campaign cancers” is planned to take organized by a candidate place at the KCB Leadership participating in the DoI for the The IUIS has a commitment to Center in Nairobi/Kenya from ﬁrst time 23 to 28 September 2018 One form of this support is with Best 2017, 2018 or 2019 Theme the generation of Research Topics. • IUIS-ALAI Immuno-Informatics Award, by IUIS – 1000 euros for The Publications Committee course Mexico April 2019 the best campaign organized by actively seeks for editors for a candidate participating in the a special focused group of INTERNATIONAL DAY OF DoI, which corresponds to one publications (Research topics) of the year’s themes (IGE-Allergy amongst immunologists willing Next year’s theme of the DoI will 2017, Vaccine Developments to contribute with gathering be Cancer Checkpoint Blockade. in Tuberculosis 2018, Cancer articles of their research interest. Checkpoint Blockade 2019) Now, members of the Council IUIS has now established special and of chairs of each of the IUIS Awards totalling 5000 euros IUIS 2019 Beijing (The 17th committees will also seek for that will be given once every International Congress of these contributions. Great news 3 years for the 4 best public Immunology) will take place at – an incentive of $2000USD has relations campaigns of the Day of the Chinese National Convention been approved by the council for Immunology for 2017, 2018 and Centre in Beijing, from October 18 the editors recruited via the IUIS, 2019: - 23, 2019. The Scientiﬁc Program which will help paying for their • International Day of Committee will be chaired by own publications expense. Immunology Award, by IUIS Xuetao Cao and Vijay Kuchroo will - 2000 euros for the best serve as vice-Chair. ACTIVITIES OF THE EDUCATION international campaign COMMITTEE • European Day of Immunology A very energetic Education Award, by EFIS - 2000 euros committee supports a number of for the best campaign in Important dates: iuis2019.org courses and there is always room Europe, where the annual DoI • Early Registration opens to participate. Indeed, a course has been celebrated since 2005 November 2018 in the FIMSA region (most likely India) this November is on the • Abstract Submission opens cards and being organised. September 2018

• IUIS-FAIS-SMI-Immuno- Morocco 2018: 2nd Regional North African Immunology Course on “Cancer, Inﬂammation and Immunotherapy”: 3-7 April 2018, in Fes/Morocco

• ISIA-IUIS Advanced Course on Immunotherapy, Tehran/Iran, 23-25 April 2018

• Stipends for the German Society for Immunology (DGfI) Spring School in Ettal, Germany (18-23 March 2018)

• Travel awards for AAI Introductory course (10-15 June 2018) and AAI Advanced course (23-27 July 2018)

13 DAY OF IMMUNOLOGY REPORTS

IN MEMORY OF DEREK HART ASI NEWSLETTER JUNE 2018

IN MEMORY OF DEREK HART: DENDRITIC CELL PIONEER MARK HOGARTH, GEORGINA CLARK AND BARBARA FAZEKAS

Professor Derek Hart was a pioneer contributed the blood sample that of the human dendritic cell field. Andrew McMichael used to define He was the first to identify human HLA-A0201. It was during this time, dendritic cells and developed while studying expression of HLA- this important discovery into an antigens on human renal tissue, inspired program of research that that he identified morphologically encompassed fundamental science unusual interstitial cells with combined with development branched dendrite-like cytoplasmic of novel therapeutics including extensions … the human dendritic dendritic cell vaccines and cell had been discovered. This monoclonal antibodies. crucial finding underpinned his career-long pioneering research Derek was a clinician and a on dendritic cells and their researcher who saw medicine and manipulation in transplantation science as intimately linked: for and ultimately in immune therapy. him, aspiration to best practice In one of his seminal papers DEREK HART, PIONEER OF HUMAN in one field drove best practice DENDRITIC CELL (1952 – 2017 published in 1981, he predicted in the other. His career was one that monoclonal antibodies would of indefatigable commitment to be useful for controlling immune clinical practice and ‘translational’ characterisation of cell surface responses in transplantation and research. The breadth of his molecules. This was the start of the cancer therapy. vision was evident at every major highly productive Hart/Clark team milestone of his career. Derek returned to Christchurch in that produced much influential 1983, completed his haematology Derek Hart was born and educated research on human dendritic cell training, and with his mentor in New Zealand, graduating with immunology and dendritic cell role Dr Mike Beard published an distinction from the Faculty of in disease. Derek was instrumental indispensable guide for junior Medicine at the University of in bringing immunology into the doctors in the initial treatment of Otago in 1976. After graduation he clinical laboratories in Christchurch, medical problems. This became won a Rhodes Fellowship to the setting up immunophenotyping an invaluable companion to all University of Oxford, which he took for leukaemias and lymphomas hospital resident doctors, and has up at Brasenose College and the and bringing MRC sponsored trials remained in print with constant Nuffield Department of Surgery, for new therapies to New Zealand updates since then. He was under the supervision of Sir Peter patients with haematological appointed Head of the Clinical Morris. He submitted his DPhil on cancers. Haematology and Bone Marrow transplantation antigens in 1981. Opportunity arose to establish Transplant Units and set up his The time at Oxford was pivotal a new research institute at the first dendritic cell laboratory. for Derek. He learned how to Mater Hospital in Brisbane and in He convinced Georgina Clark, make monoclonal antibodies from 1998 Derek was appointed as the who was working in the Nuffield Caesar Milstein, and made some inaugural Director. He set out with Department of Surgery, to join of the first monoclonal antibodies his usual energy to establish the the department in Christchurch to histocompatibility antigens. Mater Medical Research Institute as the driving force behind Little known is the fact that he as an international research hub, molecular-based discovery and

14 IN MEMORY OF DEREK HART ASI NEWSLETTER JUNE 2018

actively recruiting researchers Derek was a generous colleague Steinman to Australia to talk at from around the globe. Together and friend. He mentored numerous the first DC Symposium held in with Ian Frazer, he initiated the clinician and basic scientists, conjunction with the opening development of the Translational of the Mater Medical Research establishing many in their careers. Research Institute in Queensland Institute. Free registration before being recruited in 2000 persuading financers to invest. To and vigorous discussion were to the ANZAC Research Institute set up DendroCyte BioTech Pty the established principles at and the University of Sydney as Ltd, which holds IP around immune this annual symposium, which Professor of Transplantation and therapies including DC vaccines, continues at the ANZAC where Immunotherapy and NHMRC monoclonal antibody therapeutics the DC Down Under meetings Senior Principal Research Fellow. and immune diagnostics, he and are an annual highlight for the Australasian dendritic cell research With the move to Sydney and the Georgina mortgaged the house - a community. establishment of the Dendritic Cell perfect example of Derek’s belief Research group at the ANZAC, that one should put one’s money Despite ultimately settling in Derek and Georgina brought where one’s mouth is. DendroCyte Australia, Derek retained great together postgraduate students, BioTech is committed to bringing oncologists, transplanters, novel immune therapies into sporting output - in particular, the immunologists, haematologists and clinical practice, the first of exploits of the All Blacks and the many other to integrate and apply which is a human monoclonal New Zealand America’s Cup sailors the research of three decades into antibody that targets and deletes who reflected his own interests active programs across clinical human dendritic cells as they as a university rugby player and departments in the University of become activated, preventing the dedicated sailor. Sydney and its associated hospitals detrimental immune response but Derek faced his final illness with and institutes. During this time, leaving the rest of the dendritic Derek was recognised as a Paul cell compartment intact for future metastatic cancer approached, Harris Fellow, and a Royal College immune protection. This will be of Pathologists Distinguished developed for the prevention the goals that had inspired Fellow, amongst numerous other of graft versus host disease in a accolades. Derek’s commitment clinical setting. to immunology and medical to the importance of science in Derek was a generous colleague research from the premature end medicine and the central place of and friend. He mentored numerous the clinician scientist in improving clinician and basic scientists, by the legacy he made with every medical care inspired a generation establishing many in their careers. of researchers and his legacy will Many benefited from his tireless bequeath. We and the rest of the continue through the Dendritic Cell Research group at the ANZAC dendritic cells. He enticed Ralph come. Research Institute.

Derek ﬁrmly believed that Australian medical research generally, and immune therapy in particular, should be actively moved to clinical testing, and that a strong Australian focus should be retained throughout the entire clinical trial process. The vision of the self-perpetuating virtuous cycle of research/investment/ medicines/industry development is shared by many, but Derek was one of the very few who implemented it by drawing together commercial experts, creating a company structure and DEREK, MENTOR TO SCIENTISTS AND CLINICIANS, ANZAC INSTITUTE

15 DAY OF IMMUNOLOGY REPORT ASI NEWSLETTER JUNE 2018

DAY OF IMMUNOLOGY 2018 DR GABRIELLA KHOURY

Once again it is fabulous to see the growing interest from our ASI members in engaging the public with immunology. In 2018 we have seen the roll out of our national Day of Immunology logo (designed by Jie Zhou) and new branding (you can get a taste in the right panel). We have also welcomed two new organising committees - NSW and Tasmania. Thank you to Helen McGuire, Angelica Lau, Derek Williamson and Fabio Luciani (NSW) and Kristof Wing (Tasmania) for your hard work expanding Day of Immunology into your states.

This year was by far the largest and best range of events we have hosted to date. Five public lectures were hosted in 5 states! Multiple primary and secondary school workshops were held in Victoria and Queensland. Eleven research institutes around Australia opened their doors to the public by running discovery tours. The NSW committee reached out to students in regional NSW with their innovative event “Facetime with a scientist”. There was also a museum exhibition, immunology pub trivia, a ﬂashmob and a

This year was by far the largest and best range of events we have hosted to date. Five public lectures were MELBOURNE PUBLIC LECTURE – IMMUNOTHERAPIES TO TREAT DISEASE. PROF ROBYN hosted in 5 states! O’HEHIR (SPEAKER). PHOTO COURTESY OF HYNESITE PHOTOGRAPHY.

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ASI NEWSLETTER JUNE 2018

Multiple primary and secondary school workshops were held in Victoria and Queensland.

DAY OF IMMUNOLOGY VOLUNTEERS DISCUSS THEIR RESEARCH WITH FEDERAL GREENS MP ADAM BANDT . PHOTO COURTESY OF HYNESITE PHOTOGRAPHY.

ASI PRESIDENT SU HEINZEL DISCUSSED IMMUNOLOGY WITH THE MEDIA AT THE MELBOURNE VACCINATION CAFÉ. PHOTO COURTESY OF HYNESITE PHOTOGRAPHY.

DAY OF IMMUNOLOGY VOLUNTEERS MET WITH VICTORIAN STATE HEALTH MINISTER JILL HENNESSY (DEPARTMENT OF HEALTH AND HUMAN SERVICES). PHOTO COURTESY OF HYNESITE PHOTOGRAPHY

CAREERS IN IMMUNOLOGY SESSION. DR JESSICA BORGER DISCUSSES A CAREER IN CAREERS IN IMMUNOLOGY SESSION. RESEARCH WITH SECONDARY STUDENTS AND GTAC SECONDARY SCHOOL WORKSHOP. PHOTO COURTESY OF HYNESITE PHOTO COURTESY OF HYNESITE PHOTOGRAPHY. PHOTOGRAPHY.

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DAY OF IMMUNOLOGY REPORT ASI NEWSLETTER JUNE 2018

FLASHMOB – DANCING FOR IMMUNOLOGY. PHOTO COURTESY OF GABRIELA KHOURY.

vaccination café! In Victoria I attracted Federal Minister Adam Bandt, Victorian Health Minister Jill Hennessy and documentary film director Sonya Pemberton to the Melbourne vaccination café.

Congratulations to all of the organising committees and thank you to all the volunteers who contributed their time to make 2018 such a successful year. Enjoy reading the Day of Immunology featured articles in this issue!!!

I’m already looking forward to 2019! Rumour has it that Day of Immunology will be reaching Canberra!

Eleven research institutes around Australia opened their doors to the public by running discovery tours... There was also a museum exhibition, immunology pub trivia, a flashmob PART OF THE FLASHMOB – DANCING FOR IMMUNOLOGY. PHOTO COURTESY OF and a vaccination café! GABRIELA KHOURY.

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THANK YOU FLASHMOBBERS!

This is a chronical all about how, a squad of scientists turned Melbourne upside down!

a pod of purple dancers began to click and tap!

Dr Catherine Osborne counted them in, and crowds of Melburnians stared on with big grins!

Shoppers and city slickers watched with wonder, as synchronised scientists tried to dance without blunder!

from Bourke Street Mall to Federation Square!

Catherine called the chorey ... High! Low! and Rainbow!

The hive of entertainers buzzed here and bounced there, spreading the good word of vaccine science to whom had a care!

At the booked-out vax café with co ee in hand,

grand!

Thank you to all who shared the good vibe, from all of us here at the JLR tribe.

JOMAR LIFE RESEARCH 1 Dalmore Drive, Scoresby VIC 3179 1 300 543 373 Videos & Pics > www.Jlresearch.com.au/Flashmob

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DAY OF IMMUNOLOGY IN VIC ASI NEWSLETTER JUNE 2018

DAY OF IMMUNOLOGY IN VIC DR. KIM PHAM VIC Day of Immunology coordinator and chair (2016-2018)

International Day of Immunology in Victoria was celebrated by a staggering 14 events, engaging over 1500 members of the public and students. A cast of at least 50 enthusiastic ASI scientists from all over Melbourne celebrated immunology through:

Public Lecture on ‘Immunotherapy’: We had a fully booked event of over 250 attendees at the Doherty Institute. The lecture was opened by ASI’s president Su Heinzel and chaired by Associate Professor Edwin Hawkins (WEHI). This year’s speakers included Professor Robyn O’Hehir AO L-R: PROFESSOR ROBYN O’HEHIR, ASSOCIATE PROFESSOR EDWIN HAWKINS, ASI (Monash) on thunderstorm asthma PRESIDENT SUSANNE HEINZEL, PROFESSOR TOM KAY, DR SHANEEN SHANDU, DR. DANIEL PELLICI. PHOTO CREDIT: MONASH UNIVERSITY, HYNESITE PHOTOGRAPHY immunotherapies, Professor Tom Kay (St. Vincent’s Institute) on immunotherapies for diabetes, and Dr Shahneen Sandhu (Peter MacCallum Cancer Centre) on cancer immunotherapies.

Workshops for Secondary School Students: Four workshops were held collectively at GTAC (Parkville), Federation University Ballarat and Federation University Berwick, educating 320 Year 12 student school groups with full day practical immunology workshops and lectures by prominent immunologists followed by scientific career planning sessions. Notable speakers included Sir Gus Nossal, Professor Phil Hodgkin, Professor David Tarlinton and Dr ASI SCIENTISTS SUPPORTING IMMUNITY OF THE COMMUNITY AT THE VACCINATION CAFÉ. PHOTO CREDIT: MONASH UNIVERSITY Morgan Wallace.

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DAY OF IMMUNOLOGY IN VIC ASI NEWSLETTER JUNE 2018

Vaccination Café: Approximately Thank you to our sponsors for supporting our events, and again to 650 members of the public the scientists from all over Victoria. It has been a pleasure seeing the entered Melbourne Town Hall Victorian events grow in size and impact. and were given a chance to speak to ASI member scientists about the science of vaccination, including those from Monash Alfred Medical Research and Education Precinct (AMREP), The University of Melbourne Department of Microbiology and Immunology, CSIRO, Hudson Institute of Medical Research, Peter Doherty Institute (PDI), and WEHI. Educational videos on the immune system and immunisation science from WHO Flu Centre, Sonya Pemberton

(producer of Jabbed- Fear HIGH SCHOOL WORKSHOPS AT GTAC, PARKVILLE. PHOTO CREDIT: MONASH UNIVERSITY of Vaccines), Immunisation Coalition and WEHI were on display as the public received their double shot of influenza vaccines and complimentary coffee. ASI president Susanne Heinzel attended the vaccination café, as well as Federal Minister for Melbourne Adam Bandt and the Victorian Health Minister Jill Hennessy who thanked ASI scientists and immunisation FIND THE PERFECT nurses to contributing to FIND THE PERFECT “immunity for the community”. FIT FOR YOUR LAB There was even an immunology flash mob dance!

Discovery Tours: Eight research institutes and universities around Melbourne opened their doors to the public to raise awareness of Meet our family of multimode plate readers - including the importance of our immune ourMeet newest our family addition, of multimode the VICTOR plate Nivo readers system - including our newest addition, the VICTOR Nivo system system. Over 300 members of PerkinElmer’s portfolio of microplate readers are all equipped with multiple detection modes to PerkinElmer’smeet the diverse portfolio assay ofrequirements microplate ofreaders today’s are laboratories. all equipped No with matter multiple which detection one you modes choose, to the public registered to attend meetyou can the expect diverse excellent assay requirements performance of and today’s reliability. laboratories. With the No variety matter of which models, one configurations you choose, youand canaccessories, expect excellent there’s a performance PerkinElmer plateand reliability. reader to With match the both variety your of throughput models, configurations needs and these tours, which gave a glimpse andyour accessories,budget. there’s a PerkinElmer plate reader to match both your throughput needs and VICTOR Nivo™ Multimode Plate Reader your budget. to cutting-edge immunology Plus, you can benefit from our >30 years’ experience in assay VICTOR Nivo™ Multimode Plate Reader Plus,and instrument you can benefit development, from our and >30 our years’ vast experience array of in assay research being done in Victoria. andcomplementary instrument development,products and servicesand our -vast reagents, array ofassays, complementarymicroplates, informatics, products consultancyand services and - reagents, technical assays, support, We thank the following institutes microplates,and instrument informatics, maintenance consultancy and servicing and technical - for a complete support, and University departments: andsolution instrument for your maintenance research. and servicing - for a complete solution for your research. AMREP, Burnet Institute, Hudson Institute of Medical Research, EnVision® Multimode Plate Reader EnSight™ Multimode Plate Reader La Trobe Institute for Molecular EnVision® Multimode Plate Reader EnSight™ Multimode Plate Reader Science (LIMS), Monash Biomedicine Discovery Institute, For any additional information, please contact Nick Jones, [email protected] PDI, Peter MacCallum Cancer FForo rresearch mor euse i nonly.fo rNotm afort iuseon in v diagnosticisit ww procedures.w.perkinelmer.com Centre, and WEHI. For research use only. Not for use in diagnostic procedures.

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DAY OF IMMUNOLOGY IN NSW ASI NEWSLETTER JUNE 2018

DAY OF IMMUNOLOGY IN NSW

DAY OF IMMUNOLOGY DISCOVERY TOURS AT THE GARVAN INSTITUTE ANGELICA LAU AND JOANNE REED

On the fateful day of May 4th (and multiple references to Star wars, undoubtedly), Garvan Institute hosted 60 students from years 10 – 12 from 6 different high schools. Our very own Professor Stuart Tangye set the scene with an introduction to basic immunology, likening the adaptive immune system to the “storm troopers” keeping in place the rebel “infections” while Professor Tony Basten followed with insights into clinical immunology, putting the importance of Immunological research into context.

Armed with a new appreciation for the immune system, the students headed to the lab to get some hands on experience with the everyday technologies we use to SNAP SHOT AT THE GARVAN DISCOVERY TOUR, STUDENTS FROM VARIOUS SCHOOLS research the immune system and PARTICIPATING IN HANDS-ON LABORATORY ACTIVITIES INCLUDING MICROSCOPY, ELISA, GEL ELECTROPHORESIS all its complications.

We were very grateful to have the support from both students Armstrong, Peter Schofield, One of the most popular activities and researchers from the Garvan Stacey Walters and Clara Young) was the Garvan-Weizmann Cell Immunology Division to help who tirelessly demonstrated Observatory – an interactive us run this event as well as the and encouraged the students to virtual reality game designed to financial support from the Garvan take part in laboratory activities engage and educate students Foundation. We particularly would including flow cytometry, about cellular genomics. All like to thank the fantastic and cell culture, microscopy, gel students and teachers were enthusiastic team of volunteers: electrophoresis, cloning, enzyme encouraged to ask questions Julia Bier, Megan Faulks, Julia linked immunosorbent assay and and have a go at the lab Kiss, Wenyan Li, Imogen Moran, Biolayer Inferometry. activities. After all the fun in Bethany Pillay, Hira Saeed, Melissa

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DAY OF IMMUNOLOGY IN NSW ASI NEWSLETTER JUNE 2018

DR ANGELICA LAU & DR JOANNE REED COINCIDENTALLY MATCHING FOR THE COORDINATORS JOANNE AND ANGELICA (MIDDLE) WITH JULIA KISS (2ND FROM RIGHT) DAY OF IMMUNOLOGY! FROM THE GARVAN FOUNDATION AND HER TEAM OF VOLUNTEERS

the lab, the students gathered for a careers session with three engaging speakers at different stages of their careers. Debbie Burnett – Immunology PhD student, Dr. Katherine Jackson – Computational Immunologist and Dr. Marie Dziadek – Garvan’s Chief Scientific Officer, each spoke about their career and all the experiences that went with it. The day concluded with a Q&A session with prizes awarded to students with the most insightful questions. The students showed great interest and asked interesting questions! We thank the Garvan Foundation for sponsoring this event and we look forward to continue celebrating the Day of Immunology and supporting this wonderful opportunity to engage and educate the young bright minds out there.

Check out Garvan’s coverage of our amazing immunology celebration! www.garvan.org.au/news-events/ news/day-of-immunology- engaging-a-new-generation-of- researchers

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DAY OF IMMUNOLOGY IN NSW ASI NEWSLETTER JUNE 2018

DOI AT THE MUSEUM OF HUMAN DISEASE, UNSW great to see students asked many questions and Derek received FABIO LUCIANI, UNSW good feedback on how helpful this We have partnered with the Museum of Human Disease has activity was for them. Museum of Human Diseases at established a wonderful program During the week of DoI, we the UNSW Campus in Randwick, with NSW Schools. On May 1st, organised two teams of PhD Sydney to establish a closer students from years 11 and 12 students and early career contact with general public and engaged with several PhD students researchers to meet with 5 notably schools! and early career researchers (from schools across NSW. Two of University of Sydney; Caroline these physically visited the Face-time with an immunologist Ashley, Tessa Campbell, Chelsea Museum, while the rest was for high school students Gerada, Kevin Zhang, and from via educational teleconference As tradition of DoI in NSW, we have the Garvan Institute; Angelica Lau interface Dart Connections.org.au. run for the 5th year in a row the and Simon Pelham) on how the This experience aimed to provide “face-time with an immunologist”. immune system works, and also support for their HSC studies and Derek Williamson, director of the to discuss career paths. It was syllabus, as well as to give these young minds some “directions” on what research is, how to best choose their career path at a University and to have a clearer understanding of what research comprises of and how this can be helpful for the broader society.

Engaging with general public

This year DoI was close to the NSW School Holiday break. We took this opportunity to set up the Museum of Human Disease with several activities and tools that the general public, family and children could use to get some more insight on our amazing immune system.

With courtesy of Dr Tri Phan

ENTHUSIASTIC STUDENTS KEVIN ZHANG, CHELSEA GERADA FACE-TIMING REGION from the Garvan Institute and SCHOOLS the great support of Tim Burykin (Uni Syd) who turned Tri’s movie into a 3D interactive display, we set up a virtual reality based on live imaging of B cells in the

During the week of DoI, we organised two teams of PhD students and early career researchers to meet with 5 THE FACE-TIME CREW (L-R) DEREK WILLIAMSON, SIMON PELHEM, ANGELICA LAU, CHELSEA GERADA, TESSA CAMPBELL, FABIO LUCIANI, CAROLINE ASHLEY schools across NSW.

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DAY OF IMMUNOLOGY IN NSW ASI NEWSLETTER JUNE 2018

HIGHLIGHTS AT THE MUSEUM OF HUMAN DISEASE, UNSW, SHOWCASING THE WONDERS OF THE IMMUNE SYSTEM AT DAY OF I MMUNOLOGY 2018

lymph node using intravital live QR codes using smartphones. imaging. We had a great group of Four barcodes were positions PhD students, Mikaela Coleman throughout the museum rooms and Jackie Marshall (University and people enjoyed integrating of Sydney), Corinne Letendre the visit with interacting activities. (Western Sydney University), Other activities included 3D Angelica Lau (Garvan) that printed antibodies and antigens! organised a great set of fantastic Visitors enjoyed how antibodies activities, including a virtual recognise any sort of structures! journey on how the “Immune There were several materials and battle” against pathogens. This prints on vaccination, allergy and ANGELICA LAU & SIMON PELHEM, general immunology, utilising was based on animated videos GARVAN INSTITUTE that were accessible via scanning imaging, quiz and puzzles.

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DAY OF IMMUNOLOGY IN NSW ASI NEWSLETTER JUNE 2018

DAY OF IMMUNOLOGY PUBLIC FORUM: IMMUNOTHERAPY AND The evening began with a unique welcome reception, with drinks CANCER, 3 PERSPECTIVES and canapes served amongst TESSA CAMPBELL AND CAROLINE ASHLEY displays of selected finalist posters Department of Infectious Diseases & Immunology, University of Sydney from ASI student members. Email: [email protected], [email protected] However, far from an intensive Twitter: @ScientistTess, @Carolinelashley conference poster, these displays communicated immunology A recent global survey (3M State of Science Index) found a third of concepts to the general public, participants were sceptical of science, indicating how crucial it is for especially tailored to a high school the scientific community to work towards better communication and audience. It was fantastic to see involvement with the general public. The ASI Day of Immunology Public attendees engaged and inspired Forum, organised by ASI NSW Councillor Dr Helen McGuire and held on by the immunology, covering 23rd April 2018 at the Charles Perkins Centre, University of Sydney was an topics from vaccination to cells of example of the perfect event to facilitate this. the immune system.

Attendees were also encouraged to get involved by casting their vote for the People’s Choice poster award. By the end of the evening the posters were covered in colourful (and often comical!) stickers reading “This will go viral!” “This poster deserves a complement!”, “This work is infectious!”, and “I ♥ Immunology”. The winning posters were ‘Viral manipulation of the host immune response’ from Caroline Ashley (University of Sydney) and ‘Natural killer cells: Ninjas of the immune system’ from Tessa Campbell (University of Sydney). ATTENDEES ENJOYING THE DISPLAY OF IMMUNOLOGY POSTERS Buoyed by immunology ideas from the posters, attendees were then invited to three inspiring talks presenting different perspectives on cancer, facilitated by A/Prof Kellie Charles (University of Sydney). We first heard from Dr Joanne Reed (Garvan Institute of Medical Research) who gave great insight into how scientists approach the complex field of cancer research. Prof Ian Chubb AC then discussed the impact of clinical trials from a patient’s perspective, having recently recovered from cancer. The forum concluded with A/ Prof Alex Menzies, a clinician and researcher with the Melanoma Institute Australia, who explained ANSWERING AUDIENCE QUESTIONS AT THE PUBLIC FORUM – L-R: A/PROF ALEX MENZIES, PROF IAN CHUBB, DR JOANNE REED, A/PROF KELLIE CHARLES

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DAY OF IMMUNOLOGY IN NSW ASI NEWSLETTER JUNE 2018

THE WINNING POSTERS COMMUNICATING IMMUNOLOGY TO THE GENERAL PUBLIC

the current breakthroughs and developments in cancer immunotherapy.

The Public Forum was a great success for all who attended, thanks to the hard work of organiser Helen McGuire. As scientists, it was an important reminder of the impact our research can have and the people our discoveries can help. For members of the general public who attended, the Forum was an invaluable insight into the powers of the immune system and the work of the Australian scientific immunology community.

* 3M State of Science Index, 2018 Global Report. A/PROF ALEX MENZIES DISCUSSING THE BENEFITS OF IMMUNOTHERAPY COMPARED TO TRADITIONAL CANCER THERAPIES

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DAY OF IMMUNOLOGY IN QLD ASI NEWSLETTER JUNE 2018

DAY OF IMMUNOLOGY IN QLD SUMAIRA HASNAIN, QLD COUNCILLOR

First I’d like to acknowledge the Day of Immunology Brisbane Organising Committee: Danielle Stanisic (lead), Ran Wang, Soi Law, Ali Zaid, Burhan Khan, Kirsty Short, Sumaira Hasnain.

ASI-QLD ran very successful DoI events at the Translational Research Institute within the SPARQ-ed (Students Performing Advanced Research Queensland) program. Two separate “Disease Outbreak” workshops were conducted designed especially for 6th and 7th graders. All the students received a DoI-ASI goodie bag at the end which was a hit! The feedback was overwhelmingly positive and ASI- QLD looks forward to continuing these workshops in 2019! A big thank you to all the DoI committee for making the event a success and to the lead Danielle Stanisic and the lead at SPARQed Ayanthi

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DAY OF IMMUNOLOGY IN QLD ASI NEWSLETTER JUNE 2018

ASI-QLD ran very successful DoI events at the Translational Research Institute within the SPARQ-ed (Students Performing Advanced Research Queensland) program. Australian Biosearch is your source for Richards for her input. Thank you Origene in Australia/New Zealand to Gabriela Khoury for promoting the event! OriGene is committed to its mission to be Here are some of the lovely “Your Gene Company”, feedback we received from the in supplying everything a researcher needs for gene based research. children and families that attended these workshops:

“My daughter had an absolutely brilliant time and she was bursting with excitement about it when she got home. Thank you for providing such a wonderful experience!”

“I just want to say Thank You for allowing my daughter the opportunity to attend this workshop. She thoroughly enjoyed herself, and is still telling family and friends about everything she learnt.”

“Thanks Danielle, my son enjoyed his day there. It is not often that Grade 6 kids get to visit a real Learn more about the suppliers we represent at: lab, so thanks for the valuable experience.” www.aust-biosearch.com.au

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DAY OF IMMUNOLOGY IN SA AND NT ASI NEWSLETTER JUNE 2018

DAY OF IMMUNOLOGY IN SA AND NT IAIN COMERFORD, SA/NT COUNCILLOR

On Friday 27th April the SA/NT the lay audience new advances talks were given by all and there branch of ASI held two events for in tumour immunotherapies, was a stimulating Q+A session Day of Immunology. showcasing local research in this afterwards. A big thank you to our area and answer questions from invited speakers for agreeing to The first event was held at the public on this topic. give up their Friday night to come Basil Hetzel Institute at Queen along and share their passion for Elizabeth Hospital featuring an We had a full house with all 200 tumour immunology! institute tour for the public and available tickets taken up. Excellent talks from local immunologists about their work. Presentations were given by Dr Kevin Fenix, Joe Wrin and Zelalem Mekonnen. The event was extremely popular and all available tickets for this event were taken up.

Following the success at BHI, an event was held that same evening at the new Biomedical precinct in Adelaide at the SAHMRI Auditorium. The theme was ‘Cancer Immunotherapies’ and our invited speakers were Professor Simon Barry, Professor Deb White, Dr Tessa Gargett and Carly Whyte. Our aim was to discuss with

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DAY OF IMMUNOLOGY IN SA AND NT ASI NEWSLETTER JUNE 2018

Our aim was to discuss with the lay audience new advances in tumour immunotherapies, showcasing local research in this area and answer questions from the public on this topic.

Organising Committees: SAHMRI event: Iain Comerford, Damon Tumes, Jasmine Wilson, Tim Tyliss, Todd Norton, Kerrie Foyle, Caitlin Abbott, Nikki Lansdown, Annabelle Small, Maleika Osman, Joe Wrin.

Basil Hetzel event: Danushka Wijesundara, Kevin Fenix, Joe Wrin, Amita Gautam-Ghadge.

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DAY OF IMMUNOLOGY IN NZ ASI NEWSLETTER JUNE 2018

DAY OF IMMUNOLOGY IN NZ DR. EMILY BISSET

The International Day of Immunology was celebrated in Otago by holding a DoI Quiz Night. As usual, there was a great turn out of approximately 80 staff and students from the University, as well as quizzers from the wider Dunedin community.

The quiz was run with a format

of an interesting immunological QUIZZERS QUIZ MARKERS fact following by a linked general knowledge quiz question. For example; Vaccination can be considered a training course for the immune system. Vaccination currently prevents between 2-3 million deaths each year. Q: Which sportsperson is New Zealand’s highest earner, with a salary of approximately $35 million? (a) Steven Adams, (b) Scott Dixon, (c) Lydia Ko, (d) Winston Reid. QUIZ MASTER MC-MHC QUIZ WINNERS; THE NEOANTIGENS

The quizzers were kept on their place. Also a special mention to toes by our wonderful quiz team I’LL BE BACK!teria for the master MC-MHC and immunology most creative team name. post-graduate students were on Vaccination can be considered Thank you to Medi’Ray and hand to mark the quiz and answer a training course for the BioLegend for providing the any burning immunological immune system. Vaccination prizes and ASI for supporting this question from the audience. currently prevents between event. 2-3 million deaths each year. Congratulations go to Team NeoAntigens for taking out first

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2017 GORDON ADA SENIOR AWARD WINNER ASI NEWSLETTER JUNE 2018

DR CONNIE WONG, RECIPIENT OF 2017 GORDON ADA SENIOR AWARD

2017 GORDON ADA SENIOR AWARD WINNER DR. CONNIE WONG, Monash University

My laboratory is interested in studying the body’s response to inflammation and disseminate systemically to in the brain and the gut. In particular, we are interested in how our immune ultimately cause fatal infections. This is a significant concern system responds to diseases such as stroke and colitis. given that the gut bacteria Stroke is a common and come about because of the may be antibiotic-resistant and debilitating brain injury caused patient’s immobility and the currently used anti-bacterial by the sudden interruption hospital environment they are therapy may be ineffective of blood flow to the brain. It in. Research from my laboratory or misguided. Unsurprisingly, has been recognised for many shows for the first time that a number of large clinical years that stroke patients are stroke not only damages the studies failed to demonstrate prone to infections, but very brain, but also directly weakens the efficacy of prophylactic little is known about how the immune system and gut antibiotics in the prevention and where these infections barrier in such a way that allow of post-stroke infection. The originate from. Traditionally, “bad” bacteria in the intestines findings of our research were infections were assumed to the opportunity to translocate published in Science and Nature

MY RESEARCH GOAL IS TO UNDERSTAND HOW STROKE TRIGGERS AN IMPAIRMENT OF THE IMMUNE SYSTEM AND BARRIER FUNCTION, CONTRIBUTING TO THE INCREASED RISK OF INFECTIONS FOLLOWING THIS ACUTE BRAIN INJURY.

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2017 GORDON ADA SENIOR AWARD WINNER ASI NEWSLETTER JUNE 2018

Medicine. Clearly, an alternative approach is required to tackle this significant post-stroke complication. Our discovery alters accepted paradigms and provides novel therapeutic avenues to control infection after stroke via the manipulation of gut barrier integrity. Identifying a new and better-targeted approach to limit this important cause of morbidity and mortality in stroke patients will bypass the growing problem of antibiotic resistance, ultimately improving patient outcomes.

With our insight that stroke can MEMBERS OF MY LAB, THE NEUROINFLAMMATION RESEARCH GROUP, CTR FOR INFLAM induce intestinal barrier changes, DISEASE MONASH HEALTH we became intrigued by the potential contribution of complex host-pathogen interactions within Indeed, emerging evidence to create a microenvironment the gut. In fact, it is currently suggests bidirectional interaction that is less inflammatory, while unknown whether mucosal between the gut microbiota and supporting the recruitment of bacteria that live on and interact immune system significantly anti-inflammatory neutrophils, closely with the host intestinal influences the outcome of several which jointly protects the host epithelium (and immune cells) can inflammatory diseases. As such, from colonic inflammation. regulate bacterial translocation there is renewed interest on The findings of this research after stroke. In our recent the potential of altering the gut were published in Frontiers in publication in Scientific Reports, microbiota as a novel therapeutic Immunology. Future research that we revealed that the composition method for various inflammatory provides further insight into the of intestinal mucosal microbiota diseases. Needless to say, colitis iNKT cell–microbiota–neutrophil is significantly and robustly has been one of the most studied axis has the potential to identify modified following the onset of inflammatory diseases in relation novel therapeutic avenues to stroke. Alterations in mucosal to the gut microbiota. A gut reduce the devastating impact microbiota composition following microbiota that shapes the host of colitis. Moreover, we are stroke were found to change the immune response to promote currently investigating the effect predicted functional potential of inflammation has been found of microbiota-modifying agents the microbiota, with significant to be detrimental to disease and diets as novel therapeutic increases in pathways associated outcome. Conversely, whether approaches to modulate the with infectious diseases, host immune cells can also control host response in inflammatory membrane transport, xenobiotic the microbiota composition and diseases, with feasible translational degradation, lipid metabolism impact on subsequent leukocyte relevance to clinical settings. recruitment and function is and signalling. Therefore, as we Finally, I would like to take this currently unknown. In our start to understand the peripheral opportunity to express my recent work, we examined the consequences of stroke, we gratitude to the talented and contribution of invariant natural cannot dismiss the dynamic and hardworking members of my lab. killer T (iNKT) cells in shaping intricate relationship between I work with great people who the microbiota and recruitment the brain, gut barrier integrity, teach me new things everyday of neutrophils in a mouse model microbiota and host immunity. as we work towards a common of acute colitis. An intriguing goal to make a difference. Also, finding of this study supports a I have been extremely fortunate An intriguing finding of this study changing dogma that neutrophils to have fantastic mentors and possess important regulatory supports a changing dogma that collaborators who I am sure are roles in inflammation. In fact, we neutrophils possess important super busy but yet generously demonstrated that the lack of regulatory roles in inflammation. gave me their time. iNKT cells alters the gut microbiota

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JARED PURTON AWARD RECIPIENT 2016 ASI NEWSLETTER JUNE 2018

DR. SUMAIRA HASNAIN, JARED PURTON 2016 RECIPIENT

JARED PURTON AWARD RECIPIENT 2016 SUMAIRA HASNAIN

I was honoured with the Jared Purton Award in 2016 by ASI. Since the start of I am currently applying for my postdoctoral research in March 2011, I have made significant contributions funding which would lead to discoveries that would be my to the field of immunology and published 23 manuscripts in high impact pipeline towards future grant journals including Nature Medicine. proposals and are a part of my My current research is focussed host institute. Therefore, gaining long-term vision to identify, on new strategies to cover this prestigious award has not characterise and then manipulate treatment gaps in mucosal only helped raise my national immune‐driven pathologies for inflammatory and infectious and international profile, but therapeutic use. The Jared Purton diseases. My vision is to identify, also directly aided my lab in ASI award will enable me to characterise and manipulate the generating data on a project that generate some proof of principle immune factors I have identified was previously unfunded. data for my first grant application to modulate cellular stress as lead investigator. In addition, My proposed research is focused pathways in mucosal diseases. I believe gaining this prestigious on new strategies to cover This has led to an international award would also raise my treatment gaps in mucosal patent on which I am an inventor. national and international profile. inflammatory and infectious I would spend the prize money In 2015, I was promoted to Career diseases; with strong preliminary on reagents that are key to Track Fellow by my host institute data, collaborations and generating this data on a project (Mater Research Institute – The clinical input. This has led to an that is currently not funded and University of Queensland), which international patent on which will provide a foundation for my also coincided with my return I am an inventor. My evolving independent research career. from maternity leave. This was position as an emerging leader a critical time in my career as was recognised by my host Publication of interest: Wang, I was trying to establish my institute as I was promoted R, Moniruzzaman, Md., Shuffle, independent research niche and to Career Track Fellow, which E., Lourie, R., Hasnain, S Z., applying to gain tier-1 funding. recognises my transition to 2018, Immune regulation of The cash injection into the independence. This transition into the unfolded protein response laboratory by the Jared Purton a higher level of responsibility as at the mucosal barrier in viral award enabled me to generate a Career Track Fellow has also infection, Clinical & Translational some key proof of principle coincided with my return from Immunology; e1014. Doi: 10.1002/ data in 2016-2017. In 2017, I was maternity leave. Therefore, this cti2.1014 awarded the Career Development is a critical time in my career Fellowship by NHMRC and as I am trying to establish my promoted to group leader at my independent research niche.

35 JARED PURTON AWARD RECIPIENT 2016 ASI NEWSLETTER JUNE 2018

FIGURE 1 INAPPROPRIATE ACTIVATION OF STRESS CYCLE. ALTHOUGH THE PRODUCTION OF CYTOKINES SUCH AS INTERFERONS (TYPE I) IS BENEFICIAL FOR ANTI-VIRALRESPONSES; HOWEVER, PROLONGED PRODUCTION FURTHER INDUCES PROTEIN MISFOLDING AND LEADS TO A CYCLE OF STRESS AND INFLAMMATION IN THE ABSENCE OF PATHOGENS. THESE SEQUENTIAL EVENTS DESTROY THE EPITHELIAL INTEGRITY AND LEAVE THE EPITHELIUM VULNERABLE TO OTHER CHRONIC DISEASES. THEREFORE, STRESS-REDUCING CYTOKINES SUCH AS IL-10 CAN PLAY AN IMPORTANT ROLE TO MINIMISE PROTEIN MISFOLDING AND STOP STRESS– INFLAMMATION CYCLE.

FIGURE 2 PROPOSED MECHANISM OF ANTI-VIRAL FUNCTION OF CYTOKINES. PRE-INFECTION: BASAL LEVEL OF UPR MAINTAINS THE HOMEOSTASIS OF SECRETORY CELLFUNCTION. INFECTION: HOST ER STRESS AND UPR ARE INTRINSIC MECHANISMS THAT WILL LIMIT VIRAL PROTEIN SYNTHESIS. HOWEVER, VIRUSES CAN POTENTIALLY BYPASS THESE MECHANISMS TO REPLICATE. SPECIFIC CYTOKINES (SUCH AS TYPE I IFNS) THAT INDUCE OXIDATIVE STRESS WOULD LEAD TO PROTEIN MISFOLDING WHICH WILL BE BENEFICIAL IN LIMITING VIRAL INFECTION. POST-INFECTION: FOLLOWING VIRAL CLEARANCE, THE WOUND HEALING PATHWAYS ARE ACTIVATED. SPECIFIC CYTOKINES, SUCH AS IL-10, KNOWN TO SUPPRESS UPR SIGNALS AND ER STRESS, WILL ALLOW THE RESTORATION OF NORMAL PROTEIN PRODUCTION IN THE CELLS.

36 DAY OF IMMUNOLOGY REPORTS

UPDATE ON ASI’S VISITING SPEAKER PROGRAM ASI NEWSLETTER JUNE 2018

UPDATE ON ASI’S VISITING SPEAKER PROGRAM STUART MANNERING, VSP Coordinator

The following two visiting speakers Melbourne, Uri will fly to Sydney he will present at the University will be visiting Australia and New where he will participate in the of Otago, before flying home ACT/NSW Branches’ Immunology on Friday 21st September. A big Zealand as ASI Visiting Speakers retreat (at Kiama, NS) on ‘thank you’ to Kim Jacobson for during August and September. September 13 and 14th. He then nominating Uri and hosting his Please check locally for presentation travels to Dunedin, NZ where visit. venues and times.

1. Prof Arne Akbar from University College London will be visiting Australia in August 2018. Arne’s trip will start in Perth, he arrives on Wednesday 15th of August. After a few days in Perth he will travel to Wellington, New Zealand where he will present at the Malaghan Institute on Tuesday 21st August. Arne will then attend the IgV winter conference in Melbourne which runs from Thursday 23rd to Friday 24th of August. After giving a seminar at Monash University he leaves Melbourne to return home on Tuesday 28th of August. Many thanks to Kylie Quinn for nominating Arne and hosting his visit.

2. Prof Uri Hershberg, from The Hebrew University of Jerusalem, will be visiting Australia in September 2018. Uri’s visit will start in Perth on Tuesday September 4th. He will then visit Melbourne from Friday 7th to Wednesday 12th of September. Currently Uri is scheduled to Contact us at: present at WEHI on Tuesday 11th Ozgene Pty Ltd September, other presentations [email protected] are being arranged. After www.ozgene.com/goGermline

37 DAY OF IMMUNOLOGY REPORTS

BRANCH REPORTS ASI NEWSLETTER JUNE 2018

BRANCH REPORTS

NZ BRANCH REPORT RIES LANGLEY, NZ COUNCILLOR

NZ Branch therapy for cancer. For those NZ Branch students, Meeting 26 - 27 • Dr Yury Goltsev, Research technicians, and early-career August 2018 Scientist, Department of scientists who wish to be apply for Registration Microbiology & Immunology, travel bursaries, the deadline for and Abstract Stanford University School of abstract submission is 3 July. submission for Medicine. Advanced tools for the NZ branch meeting are multi-parametric cell analysis. Brooks, Margaret Currie, Ian now open. Go to http://www. • Dr Alexandra Corbett, Senior Hermans, Sarah Hook, Fiona queenstownresearchweek.org/ for Research Officer, Doherty Radcliff, and Ries Langley. more information and to register. Institute, University of As usual, we will hold our AGM We will not be extending the Melbourne. Functions of MAIT during the branch meeting. If you abstract submission period. cells during bacterial infection. have any agenda items please Abstracts will not be accepted This years Watson Orator is send them to me prior to the after 13 July. Professor Frank Griffin, from the meeting. For those NZ Branch students, Department of Microbiology & Visiting Speakers technicians, and early-career Immunology, and Director of Ag@ scientists who wish to be apply Otago, at the University of Otago. Prof Diane Mathis (Wellington) for travel bursaries, the deadline and Dr Alan Sher (Dunedin, Our Social Function will be on for abstract submission is 3 July. Wellington) had successful visits the evening of 26th August at To be eligible you must submit to New Zealand in March. Prof Public Kitchen and Bar. The Public an abstract by this date and be a Arne Akbar is confirmed to visit Kitchen and Bar is the closest current ASI member. Wellington in August and will restaurant to the lake and offers speak at the Malaghan Institute Our International invited Speakers exceptional local cuisine made on 21 August. Prof Uri Hershberg are: from local produce caught in the will visit Otago in September hills, farmed down the road, or • Professor Cath Bollard, Director while Prof Joel Ernst will visit in caught off the coast. Tickets are of the Center for Cancer & October. only $25 for members. Immunology at the Children’s All ASI-NZ Branch student, National Health System in Queenstown Research Week postdoc, and technician members Washington DC. T cell therapy is New Zealand’s biggest are eligible for travel assistance for cancer and chronic virus annual scientific gathering to participate in VSP events. If infections. and is held in an incredible you are interested in attending a winter location. http://www. • Professor Peng Li, Principal VSP event in another NZ centre, queenstownresearchweek.org/ Investigator at the Chinese please provide me with a short asiqmb-immunology/ Academy of Sciences’ justification for the travel (why Guangzhou Institute of The ASI-NZ 2018 Organising you want to go and what it would Biomedicine & Health, and Committee are Rod Dunbar and mean for your research). Director of Wellington Zhaotai Ros Kemp (co-chairs), Anna Therapies Ltd. CAR-T cell 38 DAY OF IMMUNOLOGY REPORTS

BRANCH REPORTS ASI NEWSLETTER JUNE 2018

VIC/TAS BRANCH REPORT SCOTT MUELLER, VIC/TAS COUNCILLOR

This year around Victoria we had an exciting line- up of Day of Immunology events that show just how important this event is for engaging the public with immunology and research. The public lecture on Immunotherapy featured Professor Robyn O’Hehir, Monash University, Professor Tom Kay, VSP SPEAKERS DINNER St Vincent’s Institute of Medical Research, Doctor Shahneen Sandhu, Peter MacCallum Cancer The venue, which is right next to (Unimelb), Nathan Croft (Monash), Centre, and was chaired by Edwin the Werribee zoo, looks excellent Steve Turner (Monash), Joseph Hawkins, WEHI. The Vaccination and is readily accessible from Rosenbluh (Hudson), Kaylene Cafe was once again held at Melbourne. We have a fantastic Simpson (VCCC) and Daniela the Melbourne town hall, and in line-up invited speakers includes Zalcenstein (WEHI). This event light of this year’s demand for international speakers Andrea is growing each year and we Flu shots, it was well utilised by Ablasser (Ecole Polytechnique expect it to be an engaging and people getting in early! Discovery Fédérale de Lausanne), Arne informative day. tours were held at 9 sites across Akbar (University College 2018 sees a very busy year for Melbourne and Secondary School London) and Laiguan Ng ASI visiting speakers and lots of Workshops were held at GTAC, (A*STAR) and national speakers great talks for local members. Our Federation University Ballarat and Liz Hartland, Kanta Subbarao, first VSP for 2018 was Dr Clare Berwick. Jomar also organised Andrew Currie, Nicola Harris and Bryant (Cambridge University) a Flash Mob to support the DoI Si Ming Man. There will be ample who gave a seminar on Feb events (#immunomob on Twitter). opportunities for talks and posters 12th at the Hudson Institute By all accounts, this year’s DoI was for registrants. and at WEHI on Feb 13th and a resounding success! The IgV Masterclass will take place then at the Lorne Infection and We have an exciting second this year at the PDI on Friday Immunity conference (Feb 14-16). half of the year shaping up for 26th of October and will focus Professor Diane Mathis visited IgV events, following on from on Systems and Quantitative on March 20th, along with Prof. a number of great ASI visiting Immunology. Topics will include Christophe Benoist (both from speakers at the start of the year. transcriptomics, genomics, the Department of Microbiology First up, on Friday June 22nd, proteomics, single cell analysis and Immunology, Harvard Medical the 2018 IgV Mid-winter Seminar (including CyTOF, scRNAseq) School, USA) and presented at the will be held at the Leveson Hotel and image quantitation. half-day symposium on Immune and will feature Dr Kate Schroder Speakers include Helen McGuire Reactivity and Tolerance on March (University of Queensland) with (Centenary), Matt Dixon 20th at WEHI (organised by Daniel sponsorship generously provided Gray). The event was a resounding by Miltenyi. success and Profs. Mathis and Planning for the 2018 IgV Annual We have an exciting second half of Benoist then headed off to meeting (August 23-24) is well the year shaping up for IgV events, Thymoz on Heron Island. Our underway. This year we have an following on from a number of great third VSP for 2018 was Dr Alan exciting new venue, the Mansion ASI visiting speakers at the start of Sher from the NIH. Alan graced Werribee (www.igv2018.com). the year. ASI members with 3 seminars,

39 DAY OF IMMUNOLOGY REPORTS

BRANCH REPORTS ASI NEWSLETTER JUNE 2018

the first at the University of SA/NT BRANCH REPORT Tasmania on March 22nd (hosted by A/Prof Guna Karupiah). Alan IAIN COMERFORD, SA/NT COUNCILLOR then spoke at the Peter Doherty Institute on March 23rd (hosted by Siddhartha Mahanty and SA/NT ASI Prizes for Adelaide Immunology Retreat Kanta Subbarao, PDI) and then Immunology 2018 at the Hudson Institute (hosted • The ‘Immunology Prize’ Our next big ASI event for SA/ by Ashley Mansell) on March ($250) at the University of NT will be the 14th Annual 26th. Alan praised the quality of Adelaide awarded to the top Adelaide Immunology Retreat our VSP scheme and encouraged undergraduate immunology (AIR-14) at the McCracken us to keep it up! student. The 2018 winner is Country Club in Victor Harbour. Madelaine Massy-Westropp. Planning for the Retreat is well underway and we are delighted The IgV committee bids farewell to • The inaugural Flinders University that Dr Scott Mueller (Doherty Seth Masters and thanks him for his undergraduate immunology Institute) will be joining us as contributions. prize ($250) was won by Aiden our invited Interstate Speaker Norbury. We are also looking forward to and Dr Gabriela Minigo (Menzies a number of exciting upcoming Congratulations to Madeleine & Institute) will be our ‘local’ VSPs, including Prof. Arne Aiden! speaker from within the branch. Akbar (hosted by Kylie Quinn, Monash) who will present at Monash University as well as the IgV Annual Meeting on August 23-24th. More VSPs on the way include Prof. Uri Hershberg (Drexel University) in September hosted by Kim Jacobson, Prof Joel Ernst (New York University), Prof. Donna Farber (Columbia University) in August/September, hosted by David Tarlinton, Prof. Bob Seder (NIH) and Prof. Paul Kubes (University of Calgary).

Stay tuned for more information about these VSP events and other events throughout the year. Keep up to date with us on Facebook (www.facebook.com/ immunologygroupofvictoria) and Twitter (@ImmunoGroupVic).

Finally, the IgV committee bids farewell to Seth Masters and thanks him for his contributions, while we welcome Nick Huntington (WEHI) and two new student members to the committee: Rosemary Millen (VCCC) and Marios Koutsakos (PDI).

40 DAY OF IMMUNOLOGY REPORTS

BRANCH REPORTS ASI NEWSLETTER JUNE 2018

UA IMMUNOLOGY PRIZE WINNER MADELEINE MASSY-WESTROPP FLINDERS UNI IMMUNOLOGY PRIZE WINNER, AIDEN NORBURY

The retreat, which is aimed at giving Early Career Researchers (ECRs), PhD students, Honours students and

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41 DAY OF IMMUNOLOGY REPORTS

BRANCH REPORTS ASI NEWSLETTER JUNE 2018

WA BRANCH REPORT CONNIE JACKAMAN, WA COUNCILLOR

Day of Morning tea hosted at Curtin Su’s seminars were incredibly well Immunology Health Innovation Research received, and Su’s presentation Institute (CHIRI), 28th April activities, held on on Friday was a record attendance 28th April Staff and students at CHIRI with standing room only at the Afternoon of were invited to bring along Perkins seminar room! Immunology their best immunology-themed Public Symposium, Harry Perkins morning tea and more than a SAVE THE DATES! Institute for Medical Research, dozen creative cakes, biscuits Upcoming events 28th April and savoury dips were supplied. The best examples included a We have two international As part of Day of Immunology, red blood cell cake, neutrophil visiting speakers coming through the ASI WA student committee extracellular traps cake and the ASI international speaker (Amy Prosser, Laura Brookes, immune cell cupcakes. Everyone program:- Niamh Troy, Caitlyn Tilsed, was very enthusiastic and Wayne Aston and Lelinh Duong) • Arne Akbar, University College supportive of the entries! It was organised an afternoon of London, T cell Immunity and a great way to celebrate the Immunology Public Symposium Ageing International Day of Immunology on 28th April held at the Harry Wednesday 15th August to and to bring staff and students Perkins Institute of Medical Saturday 18th August together at CHIRI. Research. This event proved • Uri Hershberg, Drexel to be very popular, attracting National visiting speaker: University, Systems over 60 registrants. The Susanne Heinzel, Immunology program included talks from 1st – 2nd June September (dates TBC) keynote speakers Michaela Lucas (PathWest) who spoke ASI President and national Both of the speakers will present about Allergy, Claire Sharp visiting speaker, Su Heinzel, a branch seminar and will be (Murdoch University) on visited recently hosted by available to meet with local Veterinary Immunology, Phil Michaela Lucas and Connie groups. Further details for their Stumbles (Murdoch University) Jackaman. Su gave a seminar seminars/visits are to come and on Asthma and Joost Lesterhuis at the Harry Perkins Institute if you would like to schedule a and Jonathan Chee (University for Medical Research, Friday 1st meeting with either please let us of Western Australia) on June followed by a presentation know. Saturday 2nd June at the Cancer Immunology. Other • 47th ASI annual scientific Australasian Society of Clinical highlights of the day included meeting will be held 2nd-6th Immunology and Allergy presentations by WA’s talented December 2018, Pan Pacific (ASCIA), WA Immunology Day postgraduate students, followed Perth. by a sundowner and lab tours at the Perth Zoo. Su’s seminars to finish off an exciting day of were incredibly well received, immunology. and Su’s presentation on Friday was a record attendance with standing room only at the Staff and students at CHIRI were Perkins seminar room! This invited to bring along their best also was a great opportunity to immunology-themed morning tea develop stronger ties between ASI and ASCIA. Su also managed and more than a dozen creative to squeeze in a visit to the Pan cakes, biscuits and savoury dips Pacific conference site (and were supplied. The best examples importantly the dinner venue included a red blood cell cake, on the river) for the upcoming neutrophil extracellular traps cake ASI2018, to be held at Pan Pacific and immune cell cupcakes. Perth, 2nd-6th December 2018. 42 DAY OF IMMUNOLOGY REPORTS

BRANCH REPORTS ASI NEWSLETTER JUNE 2018

NSW BRANCH REPORT HELEN MCGUIRE, NSW COUNCILLOR

The first half of 2018 saw a flurry of immunology events in NSW!

Events in NSW started with Prof Alan Sher from NIH coming to Sydney on the ASI Visiting Speakers Program. Hosted by Prof Carl Feng at the Charles Perkins Centre, the University of Sydney, Alan gave a captivating seminar covering many vast aspects of his esteemed career. Alan was very generous with his time and spent two days meeting with our local immunology community, and this included a wonderful mentoring lunch with our students and ECRs. POSTGRAD AND ECR LUNCH WITH PROF ALAN SHER NSW went large with our efforts to celebrate Day of Immunology, and it paid off with some wonderfully successful events! We anticipate the following Visiting tuned for registration details Please check out the event Speakers Program invitees to travel via email! It promises to be reports written to cover each of a great program, particularly our way- Donna Farber to be hosted the three participating partners, from our students to showcase written by our brilliant ASI by Garvan in August, Uri Hershberg their hard work. We’ve also members who helped out with joining our branch meeting in lined up some great keynote organising each celebration. September, and Joel Ernst in speakers which include the nationally renown Prof The UNSW Museum of Human October, with venue to be decided. Mariapia Degli-Esposti (Lions Disease, covering school holidays Eye Institute, The University activities and our ‘Facetime an And pleased to report the of Western Australia), Prof Immunologist’ event, with report following exciting ASI events in Barbara Fazekas de St Groth by our DoI coordinator Dr Fabio NSW still yet to come for 2018; (The University of Sydney), Luciani We anticipate the following Prof Emad El Omar (UNSW), Dr The Garvan Institute of Medical Visiting Speakers Program Pablo Silveira (ANZAC Institute), Research, with report contributed invitees to travel our way- Donna and internationally Prof Uri by our fantastic Discovery tour Farber to be hosted by Garvan in Hershberg (Drexel University, coordinators Dr Joanne Reed and August, Uri Hershberg joining our Philidephila, PA, USA). Dr Angelica Lau branch meeting in September, Please feel free to contact and Joel Ernst in October, with Our immensely successful Public me if you would like to get venue to be decided. Forum hosted by the Charles more information or make any Perkins Centre, the University And of course our much suggestions for upcoming events of Sydney, with reports by our anticipated NSW/ACT branch ([email protected]. immunology student poster meeting hosted at Sebel au). I’m always keen to hear the prize-winners Caroline Ashley and Harbourside, Kiama on the thoughts of ASI members. Tessa Campbell. 13th and 14th September. Stay

43 BRANCH REPORTS ASI NEWSLETTER JUNE 2018

QLD BRANCH REPORT SUMAIRA HASNAIN, QLD COUNCILLOR

ASI-QLD has had ASI-QLD is very excited to • Associate Professor Shane Grey, a very exciting announce the opening of Garvan Institute of Medical start to the year! registrations for the Brisbane Research With a lot of Immunology Group Meeting to • Associate Professor Seth be held at Gold Coast SeaWorld Masters, Walter and Eliza Hall taking place. If Resort in September! Register Institute of Medical Research you are interested now and submit your abstracts. in getting involved in the Visiting Speaker Program There will be a prize for the activities supported by ASI-QLD Prof. Clare Bryant (Unniversity of best poster and best talk (PhD please email Sumaira.hasnain@ Cambridge) - Feb 2018 (hosted session), sponsored by ASI-QLD mater.uq.edu.au by Prof. Matt Sweet, IMB-UQ) ($250 each). Prof. Alan Sher (NIH Brisbane Immunology Group ASI-QLD is planning to support Distinguished Investigator, USA) Meeting travel bursaries for applicants – March 2018 (hosted by Prof. Organising Committee: Sumaira from North QLD to be able to Christian Engwerda, QIMR) Hasnain, Rajiv Khanna, Matt attend the meeting – keep an eye Sweet, Ray Steptoe out for the call out! ASI-QLD had the privilege of hosting two prominent Jonathon Sprent Orator: international researchers earlier ASI-QLD is planning to support Professor Gabrielle Belz travel bursaries for applicants from this year. I would like to thank Conﬁrmed Plenary Speakers: Prof. Matt Sweet and Prof. North QLD to be able to attend the • Dr Laura Mackay, Peter Doherty Christian Engwerda for hosting meeting – keep an eye out for the Institute for Infection and the speakers and making the call out! Immunity visiting speakers trip a huge success.

44 BRANCH REPORTS ASI NEWSLETTER MARCH 2018

TRANSLATIONAL RESEARCH INSTITUTE AUSTRALIA ADVANCED IMMUNOLOGY COURSE

The University of Queensland Diamantina Institute is pleased to offer a Winter Course in Advanced Immunology at the Translational Research Institute, Woolloongabba. Monday 16th - Friday 20th July 2017

THE ADVANCED IMMUNOLOGY COURSE OFFERS STUDENTS: • Advanced instruction in immunology • Advanced practical training in immunological techniques • An opportunity to meet and hear from international leaders in the field of immunology

TICKET OPTIONS: • Lectures + Practical (enrolled undergraduate student, any university) *Eligible for bursary • Lectures only (external attendees) • Lectures only (UQ staff + enrolled students (UG or PG) at any university) RISQ option available

* Three bursaries to attend the course will be awarded based on merit. If you are awarded a bursary your fee paid to attend the course will be refunded. Win a $3250 Honours Scholarship REGISTRATIONS AND APPLICATIONS OPENING SOON visit di.uq.edu.au/advanced-immunology-course 45 DAY OF IMMUNOLOGY REPORTS

WOMEN’S INITIATIVE AWARD RECIPIENTS ASI NEWSLETTER JUNE 2018

WOMEN’S INITIATIVE AWARD RECIPIENTS

DR. HAMUTAL MAZRIER SYDNEY SCHOOL OF VETERINARY SCIENCE, UNIVERSITY OF SYDNEY

Mindfulness in Brisbane would lead you to [Doctor The 2017 annual ASI meeting Graham Mitchell (Foundation I was honoured to be one of the was extremely well organised Lecture) and Professor Chris four recipients of the inaugural with impressive attendance, an Goodnow (Presidents Lecture)]. ASI Women Initiative Award. As always, any early-career, astonishing array of talks by The award allowed my family mid-career or senior researchers top international and national to join me for the recent ASI in the auditorium felt modest immunologists and well received annual meeting at Brisbane and and envy when listening to the therefore, unable me to be there workshops and events. quality research presented during for the full time and without the need to attend daily family issues from distance. The 2017 annual ASI meeting was extremely well organised with impressive attendance, an astonishing array of talks by top international and national immunologists and well received workshops and events. Considering that this meeting followed the successful ICI2016 international conference of the preceding year, this was a great achievement.

Proudly, the Sydney University Veterinary Science was well represented in the meeting as the head and tail excellent presentations were given by two veterinarians who graduated there. They inspired the audience,

talking about where good start, HIGHLIGHTS OF ASI BRISBANE FOR MY FAMILY AND I, SUPPORTED BY ASI WOMEN’S good mentors and tolerance INITIATIVE.

46 DAY OF IMMUNOLOGY REPORTS

WOMEN’S INITIATIVE AWARD RECIPIENTS ASI NEWSLETTER JUNE 2018 the New Investigator Award DR. CINDY MA Session. Two of my favourite GARVAN INSTITUTE OF MEDICAL RESEARCH, SYDNEY presentations in the conference were relevant to my own research interests: Dr Cindy Ma described In recognition that attendance monogenetic variants of cytokine to the ASI annual meeting may receptor genes in human require care-givers to be away immunodeficiencies [Lymphocyte from their home base and thus Differentiation, Activation and need alternative arrangements Memory Symposium II]; Professor for carer responsibilities, the ASI Sarah Robertson demonstrated Women’s Initiative offered 4 travel the crucial role of microRNA awards (of up to $750) to support regulation of T cell tolerance their female members attending in pregnancy [Plenary IV], the 46th Annual Scientific Meeting expending the knowledge on held in Brisbane (27th November microRNA-cytokines interactions – 1st December 2017). The funds in reproductive related tissues could be used in whatever way such as seminal fluids and reveal that best suited the recipient’s their contributions to conception personal circumstances, for rates and fertility. Social highlights example additional childcare included the well-attendant and days while the recipient attended utterly funny Lafferty Debate, the conference, child-minding which stimulated a line-up of DURING ASI 2017 ASI POSTER SESSION at the conference, or to fund a microbiome-related limericks in ALONG WITH MY TWO YOUNG CHILDREN. companion to come to Brisbane the Conference Dinner… to take on carer responsibilities The attention, discussions and while the recipient attended the set by previous ASI meetings and questions I received during the conference. For me, these awards on the back of the International poster session would contribute could not have come at a better Congress of Immunology that was to the next stages of research time and were vital to my ability held in Melbourne the previous conducted in my lab, investigating to attend the annual meeting. year. It had a stellar scientific the role of cytokine receptor I had the privilege of being an program with an excellent line- gene variants associated with invited speaker to the meeting, up of national and international canine immune-related diseases. but at the time of accepting the invited speakers. A definite Additionally, several discussions invitation I knew I would most highlight for myself was the and talks during the conference likely still be on maternity leave honour of presenting my research have emphasized the promise and primary carer for a less than to so many of my peers, which I and applicability of comparative 6-month-old baby who was still consider to be a much tougher immunology and (non-mice) being nursed. The award made audience than any other world- animal models to human diseases. it possible for my husband to stage. Outside of the scientific We are currently exploring the accompany me to Brisbane and program, I was able meet with interest amongst the ASI members act as primary carer for both numerous collaborators, including in establishing a (non-human/non- our children while I attended the Jean-Laurent Casanova who was mice) Comparative Immunology conference. This arrangement one of the international invited Workshop/SIG (please contact worked extremely well for us as plenary speakers. I was also able [email protected] there were plenty of kid-friendly to catch up with peers, many of for more details). activities close to the conference whom I also consider to be close venue, the Brisbane Convention I sincerely thank the Australasian friends. I would also like to take and Exhibition Centre, to keep Society for immunology this opportunity to commend the my 4 year old occupied, and I organisation for the opportunity ASI Women’s Initiative Councillor, was able to utilise the parenting to mindfully be there and discuss Dr Vanessa Bryant and the society facilities at the Convention Centre. immunology throughout the full for putting these measures in superb meeting! The 2017 ASI Annual Scientific place in support of their female Meeting in Brisbane definitely immunologists. lived up to the high precedent

47 DAY OF IMMUNOLOGY REPORTS

TRAVEL REPORTS ASI NEWSLETTER JUNE 2018

TRAVEL REPORTS

5TH ANNUAL MEETING OF THE INTERNATIONAL CYTOKINE AND INTERFERON SOCIETY 29 October – 2 November 2017, Kanazawa, Japan LE SON TRAN, Hudson Institute of Medical Research, Centre of Innate Immunity and Infectious Disease. E: [email protected]

Travel Report I was very grateful to D, thereby modulating host gastric receive an ASI International Travel cell survival responses; 2) whether Award which allowed me to attend targeting this signalling pathway the 2017 Cytokine Conference could activate host mucosal organised by The International immunity to promote bacterial Cytokine and Interferon Society clearance? (ICIS) in Kanazawa (Japan) in There was also a burst of interest October. in a new and fascinating field, This year’s conference program immunometabolism. The plenary was excellent and encompassed speaker, Professor Luke O’Neill, all aspects of innate and adaptive and other speakers inclusively immunity in various disease highlighted that metabolic settings. Every presentation pathways and metabolites not only seemed so intriguing and it was provide energy and substrates so hard for me to decide which for growth and survival, but symposium/workshop I would also instruct effector functions, attend each day. Of particular differentiation, and gene DELICIOUS FOOD AT THE CONFERENCE BANQUET DINNER interest to me was the talk given expression of innate immune cells. by Professor Richard Flavell These interesting presentations who was the first to elucidate drew my interest to this field, the role of the Nod-like receptor especially, as a microbiologist, was also intrigued by several families (NLRs) in innate immune I would be interested in advance technologies introduced responses. He nicely described investigating the biological effects at this conference such as single how the newly identified NLR of changes in metabolic profiles cell analysis. This technology receptor NLRP9b promotes during host-pathogen interactions is believed to pave the way for protective host defence against an in antimicrobial responses. the development of precision enteric virus infection by activating therapies. In addition, I attended some other Gasdermin-D dependent cell sessions which enabled me to stay The poster session played an death pathway. My current study abreast of advanced technology important role as an excellent demonstrated the importance of platforms that are quite useful forum to network with scientists in another NLR receptor member, for my research. Of these, I was my field. It was also a great honour NOD1, in sensing of H. pylori inspired by many talks and posters for me to present my unpublished infection, therefore his exciting related to the CAR-T cell therapy, a work at this session. My poster talk prompted me to think about rapidly emerging immunotherapy entitled “NOD1 sensing of H. some potential questions for my approach recently approved by pylori mediates IL-18 processing future research: 1) Could NOD1 FDA. I have learnt a lot by simply to maintain gastric homeostasis” also engage similar downstream having a chat with speakers received some constructive mechanisms to cleave Gasdermin after the session. In addition, I feedback on my results and 48 DAY OF IMMUNOLOGY REPORTS

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insightful suggestions as to future work from numerous distinguished international scientists. These interactive and informal conversations allowed me to make some fruitful connections with delegates who I had only known through reading their publications. I also mingled and viewed other posters which focused on emerging IL-1 cytokine family members, such as IL-33 and IL- 36. Their findings on the role and regulation of these cytokines at mucosal sites were quite relevant to my current work and provided inspiration for my future research.

The venue and food catering was very impressive, which held JAPANESE TRADITIONAL DANCE AT THE CONFERENCE BANQUET DINNER people together and encouraged network chances. I had a great time catching up with my former that this unique collaboration would like to thank ASI and The colleagues during lunch, coffee would generate data for a CASS Foundation for sponsoring breaks and banquet dinner served collaborative publication and for me to attend the conference and with plenty of delicious Japanese future grant applications. On top of visit collaborators’ laboratories. seafood. that, I was really delighted to take Particularly, I truly appreciated that In addition to attending the a ride on one of the fastest trains in ASI has continuously offered me conference, I took advantage the world, the Japanese bullet train so many opportunities to attend of this opportunity to visit two (Shinkansen), to travel to Tokyo international conferences for over laboratories in Osaka and Tokyo. where I visited the laboratory of the past seven years. I always share My first lab visit was to the Professor Masanori Hatakeyama, a my great experiences as a member laboratory of Professor Koichi world leader in H. pylori research. of the Society with students Fukase in Osaka University. His The key outcome of this visit and postdoc colleagues at my lab has extensive experience in was that I received critical inputs institution and encourage them to characterizing and synthesizing from experts in my field for my sign up for ASI membership. NOD1 ligands which are particularly manuscript which I have recently useful for my current work. After submitted for publication. I also giving a 20-minute presentation, received a lot of helpful advice I received a lot of intriguing from his laboratory staff to trouble- questions which I had never been shoot our technical issues with asked before and invaluable detecting H. pylori virulence feedback on my methods and factors. results from biochemists in his Overall, attending this conference department. Following my talk, and visiting labs in Japan were we had an in-depth discussion definitely one of my highlights to set up a cross-disciplinary for the year. This was a fantastic collaboration which will exploit the opportunity for me, as a young existing complementary resources scientist, to keep up-to-date and expertise between two with most recent findings of research groups working towards cutting-edge research in the field, understanding the functionality of develop new perspectives for my NOD signaling pathways and how research and establish fruitful to modulate this pathway in vivo collaboration with international MY LAB VISIT AT THE UNIVERSITY OF using synthetic ligands. We expect OSAKA researchers. Last but not least, I

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19TH INTERNATIONAL CONFERENCE ON LYMPHATIC TISSUES AND GERMINAL CENTRES IN IMMUNE REACTIONS San Servolo Island, Venice, Italy ILENIA PAPA, Australian National University

In September this year I had the great privilege to attend the 19th International Conference on Lymphatic Tissues and Germinal Centres in Immune Reactions, better known as The Germinal Centre Conference (GCC). The Conference is held every three years, and this year it was hosted by The IFOM in San Servolo Island, Venice (Italy). In other words … we were trapped for three days on a tiny little island with more than 150 GC experts from around the world. A great experience for some, the worse nightmare for others! Just kidding, it was a valuable time and generally speaking everyone 19TH GCC GROUP PHOTO: ALL CONFERENCE PARTICIPANTS. SAN SERVOLO PIER. TAKEN BY THE OFFICIAL PHOTOGRAPHER. got a lot out of it.

This year the meeting was also celebrating the 50th anniversary of this series of international conferences focused on the understanding of the basic mechanisms underlying the function of the adaptive immune system in health and disease. Marie Kosco-Vilbois opened the conference on behalf of Frans

The talk was really interesting and provided an overview of all discoveries made during this 50 years and which provided the basis of our understanding 19TH GCC STUDENTS: FROM THE LEFT, CRISTIAN BECCARIA, ILENIA PAPA, IMOGEN MORAN, of the germinal centre ELENA MERINO, FLORIANA CREMASCO, FAITH UWADIAE AND INKEN KELCH. BURANO, responses. VENICE. TAKEN BY CRISTIAN BECCARIA.

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Kroese, who had historically made significant contributions to the field and who unfortunately could not attend the meeting. The talk was really interesting and provided an overview of all discoveries made during this 50 years and which provided the basis of our understanding of the germinal centre responses.

All sessions were well attended throughout the whole meeting and packed with high quality talks across ten excellent sessions, which were accompanied by two poster sessions. Overall the conference addressed several topics related to the identification and functional dissection of novel molecular pathway controlling the dynamics of B and T cells within germinal centre, B cell selection and differentiation into memory and plasma cells.

There was a discrete but important Australasian presence in attendance at the meeting with talks from David Tarlinton, 19TH GCC STROLLING AROUND BURANO. PHOTO TAKEN BY INKEN KELCH. Carola Vinuesa, Kim Good- Jacobson, Di Yu, Imogen Moran and Inken Kelch presenting their outstanding work on germinal well known for its brightly centre immunology happening painted fisherman’s houses and at the moment in Australia and for the handmade Burano lace. New Zealand. There were also We had a nice time strolling several excellent opportunities through the island’s labyrinth for the younger conference Overall this conference made of narrow streets and lots attendees to present their work provided a unique opportunity of bridges and a quick stop to and I was also fortunate enough for networking and gaining cheer with a glass of Spritz. to present my work on the role invaluable feedback. I’m really Overall this conference of dopamine in human germinal looking forward to the next provided a unique opportunity centre responses in the third for networking and gaining session of the first day. I was meeting in Israel in three invaluable feedback. I’m really quite nervous and excited at the years. looking forward to the next same time to share my work with meeting in Israel in three years. that audience full of very smart people. Finally, I would like to thank glass making, where we visited the Australasian Society of In addition to the science we had one of the glass factories and Immunology for supporting this a fun boat excursion and visited watched a demonstration of the travel, and allowing me to attend two other islands in the Venetian glass blowing and glass sculpture this conference and meet great Lagoon. We went to Murano, techniques. Second stop was the scientists and maybe my future renowned for its long tradition of picturesque island of Burano, post-doc supervisor.

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THE 42ND ANNUAL INTERNATIONAL HERPESVIRUS WORKSHOP 29 July – 2 August, 2017 (Ghent, Belgium) TESSA CAMPBELL, Department of Infectious Diseases & Immunology, University of Sydney. E: [email protected] T: @ScientistTess

I count myself extremely fortunate to have been awarded an ASI Postgraduate International Travel Award last year. Going against the norm, I attended the International Herpesvirus Workshop (IHW) in July/August 2017, staged against the beautiful backdrop of Ghent, Belgium. This annual meeting presents the best opportunity for herpesvirology researchers to come together, covering a wide scope of science from hard-core virology to viral-host interactions in pathogenesis and immune cell dynamics. I was particularly eager to learn about current research on the multitudes of NK cell evasion strategies employed by cytomegalovirus, as well as recent therapy developments using herpesviruses as vaccine BEAUTIFUL GHENT IN SUMMER– A MORE PICTURESQUE LOCATION THAN MY LAST IHW IN BOISE, IDAHO vectors for cancer and chronic pain. I did my best at the meeting to help bring the immunology (and excessive flow plots), presenting my work on the inhibition of NK cell function by varicella zoster virus (VZV) and herpes simplex virus. I was delighted to give an oral presentation in the VZV workshop, and as is tradition at IHW, I additionally presented an accompanying poster, allowing further opportunity for discussion.

Speaking of tradition, IHW is a meeting with many unique customs that make for a fantastic conference experience. The attendees were treated to a night of music and dancing by the Herpetic Legion – a band of AUSTRALIAN IMMUNOLOGY-VIROLOGISTS ENJOYING THE CONFERENCE BEER. L–R: TESSA virology professors that each CAMPBELL (USYD), DAVID TSCHARKE (JCSMR, ANU), JARROD KENNEDY (USYD), THILAGA VELUSAMY (JCSMR, ANU), MEGAN STEAIN (USYD) year ‘reactivate’ to perform at the meeting. And rather than 52 DAY OF IMMUNOLOGY REPORTS

TRAVEL REPORTS ASI NEWSLETTER JUNE 2018

conference. While there are many sources to apply for conference support, it is much harder to find funding to visit international labs when considering postdoc opportunities. I am therefore incredibly grateful to ASI for its support, without which I would not have been able to visit so many labs across Europe, informing my future postdoctoral research. I am honoured to have received the Postgraduate International Travel Award, and I hope to continue representing ASI as I move into the international immunology ENJOYING THE OLD CITY OF GHENT AFTER ANOTHER PACKED DAY OF SCIENCE sphere in the next stage of my career.

* Afifa M Sultana, Ann Du, Berit a conference-sponsored bag, of Zürich, Yenan Bryceson at the Carow, Catrine M Angbjär, the organisers kept true to Karolinska Institute, Dan Davis Jessica M Weidner, Sachie Belgium and had a custom beer at the University of Manchester, Kanatani, Jonas M Fuks, Tamara produced by a group of savvy and Gillian Griffith’s group at the De Koning, Jaime James, Imogen PhD students. To everyone’s Cambridge Institute for Medical O Mansfield, Tessa M Campbell, amusement the delicious brew Research. Visiting these labs Lifeng Liu, Nadir Kadri, Henrik was named ‘Acyclobeer’ and was a valuable opportunity to Lambert, Antonio Barragan, marketed as an alternative meet with other researchers, Benedict J Chambers (2017). therapy to acyclovir for present my data and receive Down-modulation of effector herpesvirologists! constructive feedback, as well as functions in NK cells upon T. hear about the fascinating work gondii infection. Infection and But putting the fun to the side, these groups are undertaking. Immunity 85 (10): e00069-17. the IHW conference was an I am very grateful to all these excellent opportunity for me people for the time they made as a finishing PhD student to to welcome me into their labs receive feedback on my research and talk science. I was also before returning home to write able to catch up with Benedict up manuscripts and my thesis. Chambers (Karolinska) who I was thrilled to meet leading supervised me during an researchers like Stipan Jonjić undergraduate exchange project (University of Rijeka), as well many years ago. In an amazing as cement my connections and stroke of coincidence, our paper* networks within the herpesvirus on that work was accepted for field as I begin to transition publication on the day I flew into further into immunology during Stockholm, giving us the chance my postdoc. To this end, ASI’s to celebrate when I visited! funding made it possible for me to use the trip to also visit I was fortunate to additionally labs across Europe to scope out receive funding from The possible postdoc opportunities. University of Sydney (through the Daphne Goulston Scholarship While travelling, I organised to CATCHING UP AND CELEBRATING WITH and the Postgraduate Research visit several labs in line with my MY FORMER PROJECT SUPERVISOR, Support Scheme), which helped interests in NK cell immunology: BENEDICT CHAMBERS (KAROLINSKA allay the cost of attending the INSTITUTET) Christian Münz at the University

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AUSTRALASIAN SOCIETY FOR IMMUNOLOGY ASI NEWSLETTER JUNE 2018

ABOUT THE AUSTRALASIAN SOCIETY FOR IMMUNOLOGY

The aim of the ASI is to encourage ASI COUNCIL and support the discipline of immunology in the Australasian Executive region. President - Susanne Heinzel [email protected]

The Australasian Society for Vice President – John Fraser [email protected] Immunology Incorporated (ASI) Honorary Secretary - Elissa Deenick [email protected] was created by the amalgamation in 1991 of the Australian Society Treasurer - Kim Jacobson [email protected] for Immunology, formed in 1970, Deputy Treasurer – Asolina Braun [email protected] and the New Zealand Society for Immunology, formed in 1975. It is a Voting Council broadly based society, embracing NSW Councillor – Helen McGuire [email protected] clinical and experimental, cellular and molecular immunology in SA/NT Councillor - Iain Comerford [email protected] humans and animals. The Society QLD Councillor - Sumaira Hasnain [email protected] provides a network for the VIC/TAS Councillor - Scott Mueller [email protected] exchange of information and for collaboration within Australia, ACT Councillor - Ian Cockburn [email protected] New Zealand and overseas. ASI NZ Councillor - Ries Langley [email protected] members have been prominent in advancing biological and WA Councillor - Connie Jackaman [email protected] medical research worldwide. We seek to encourage the study of Non-voting council immunology in Australia and General Manager – Tyani Chan [email protected] New Zealand and are active in Facebook + Twitter Manager - Gabriela Khoury [email protected] introducing young scientists to the discipline. Newsletter Editor – Angelica Lau [email protected] IUIS Representative - Alejandro Lopez [email protected] ASI Member Benefits include: ICB Editor-in-Chief - Anne La Flamme [email protected] • International Travel Awards ICT Editor-in-Chief – Rajiv Khanna [email protected] • Bursaries to attend ASI’s Annual Meeting FIMSA Representative - Laura Mackay [email protected]

• New Investigator and Student Visiting Speaker Program – Stuart Mannering [email protected] Awards at ASI Annual Meeting Women’s Initiative Co-ordinator - Vanessa Bryant bryant.v@wehi.edu.au

• ASI Women’s Initiative to Meeting Co-ordinator - Meredith O’Keeffe [email protected] support female scientists DoI coordinator - Gabriela Khoury [email protected] • ASI Member’s benefits Honorary Archivist - Judith Greer [email protected] publishing in ASI Journals ICB and CTI 2018 LOC Meeting Co-Chair – Connie Jackaman [email protected]

• Special offers from ASI’s 2018 LOC Meeting Co-Chair – Scott Fisher [email protected] Sustaining Members

• Full access to the journals The ASI membership directory, listing all financial members of the Immunology and Cell Biology, Society is available here Clinical and Translational Immunology To join the ASI or renew your subscription, go here