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Tailor Made Compounding PEPTIDE CATALOG TAILOR MADE COMPOUNDING Phone: 1 859 887 0013 | Email: [email protected] Our Story | 04-05 MK-677 | 36 Peptide Fact Sheets | 06-55 Myristyl | 37 3-Desoxy DHEA | 08 NMN | 38 5-Amino-1MQ | 09 PEG-MGF | 39 Amlexanox | 10 Pentosan Polysulfate | 40 AMT | 11 PNC-27 | 41 Aniracetam | 12 PT-141 | 42 AOD 9604 | 13 PTD-DBM | 43 AOD 9604 + HA | 14 RG3, Methylcobalamin, NAD+ | 44 BPC-157 | 15 Sarms LGD-4033 | 45 Cerebrolysin | 16 Selank | 46 CJC-1295 | 17 Semax | 47 DHH-B | 18 Tesamorelin | 48 Dihexa | 19 Tesofensine | 49 DSIP | 20 Tetradecylthioacetic Acid (TTA) | 50 Eclomiphene | 21 Thymosin Alpha-1 | 51 Epitalon | 22 Thymosin Beta | 52 FGL (l) | 23 VIP | 53 GHK-Cu | 24 Zinc Thymulin | 54 TABLE OF TABLE Glycyrrhetinic Acid & Aminophylline Dosing Charts | 25 56-62 Transdermal Fat Loss Cream Licensed States | 64-65 IGF-1 | 26 TMC App | 66-67 Ipamorelin | 27 Contact Us | 68 iRGD | 28 Kisspeptin-10 | 29 KPV | 30 Leuphasyl | 31 LL-37 | 32 Malanotan II | 33 Met-Enkephalin | 34 MOTS-c | 35 CONTENTS Tailor Made Compounding was launched United States. Since the inception of TMC, in the U.S. in January of 2016. We have we have sourced and compounded over 40 since become a major contributor to unique peptides. We are proud to be the peptide medicines in the integrative first in the United States to offer health space. compounds like CJC 1295, Bremelanotide, OUR PT 141, BPC-157, and Epitalon and Through our compounding expertise, continue to introduce new and exciting knowledge and experience, we have compounds to our formulary. quickly grown as one of the top compounding pharmacies in the nation. At Tailor Made, we pride ourselves in being STORY Together, with our sister pharmacies partners with our practitioners and their around the world, we have established a staff. That’s why a major part of what we reputation for working closely with our do involves educating our prescribers on physicians and are well known for the products we develop, including their obtaining difficult to source and hard to clinical indications, and dosing. Through compound pharmaceuticals. Our sister building these relationships and creating facility and first establishment, Como cutting-edge peptide therapies, we compounding in Melbourne, has been promise to maintain our status as leaders in working with peptide therapies for over a the industry. Collectively, all of our decade. After witnessing the success these locations work to support the same products were having for both doctors and mission; To positively disrupt medicine patients in Australia, we saw the demand using innovative technologies through to bring our compounding expertise to the education and partnership. Positively disrupting medicine using innovative technology 04 05 PEPTIDE FACT SHEETS At Tailor Made Compounding, we want you to have all the required information to understand the products we offer. Our peptide fact sheets contain a description, protocol, and clinical reasearch for each product. If you have any further questions please reach out to us: Phone: 1 859 887 0013 Email: [email protected] 06 07 3-Desoxy DHEA 5-amino-1MQ Purity: >98% (HPLC on request) | Molecular Formula:R1=H, R2=CH3 Purity: >98% (HPLC on request) | Molecular Formula: C10H11N2 Molecular Weight: 288.43 g/mol | Sequence: Non-Peptide Molecular Weight: 159.21 g/mol | Sequence: Non-Peptide DESCRIPTION: DESCRIPTION: 3-Desoxy DHEA is a competitive aromatase aromatase inhibition only occurs while 3-Desoxy 5-amino-1MQ is a small, selective, membrane permeable to prevent adipogenesis and type II diabetes and reverse inhibitor for use in controlling estrogen and DHEA is present in the body. 3-Desoxy DHEA molecule that is an inhibitor of nicotinamide diet-induced obesity as a result of increased intracellular increasing endogenous testosterone production. is a relatively quickly metabolized compound N-methyltransferase (NNMT), a cytosolic enzyme that NAD+ and SAM. plays a role in cellular metabolism and energy In a study using diet-induced obsese mice fed a high fat This compound is shown to potently reduce and has an excellent potency with IC50 and Ki homeostasis. NNMT has been found to be up-regualted diet, the effects of 5-amino-1MQ on obesity measures and aromatase activity through binding to the values. 3-Desoxy DHEA offers you a new option in white adipose tissue of mice compared to other tissues, plasma lipid were evaluated. After 11 days, mice treated enzyme and blocking access to endogenous for estrogen control and natural testosterone thus, NNMT is an ideal target for anti-obesity medication. with 5-amino-1MQ lost weight, exhibited a decrease in estrogen precursors (androstenedione, elevation along with a high potency coupled with 5-amino-1MQ is a derivative of methylquinolinium (MQ) white adipose mass and cholesterol levels, and displayed testosterone). The competitive inhibition offers a better dose control. which has exhibited a high efficacy in NNMT inhibition, reduced lipogenesis. The results of this study validate cell viability, and membrane permeability. It did not have NNMT as a practical target to treat obesity and related more short term solution to estrogen control, as any effect on the activity of any other enzymes in the metabolic conditions and support the development of an relevant metabolic cycles, therefore reducing the risks of NNMT inhibitor therapeutics to reverse diet-induced PROTOCOL: potential side effects. This NNMT inhibitor could be used obesity. Content & Potency: 100mg capsules provided in quantity of 30. Suggested dosage: Take 1 capsule by mouth once daily. PROTOCOL: Content & Potency: 10ml at 300mg/ml CLINICAL RESEARCH: Suggested dosage: 150mcg (.5ml) daily for 20 days 30 minutes after oral administration of NAD+ precursor What is desoxy-DHEA and How Does it Work? Although Desoxy DHEA is an effective competitive selected in vitro data. Competitive aromatase inhibition inhibitor of aromatase it is not nearly as potent as SERMs works differently than suicide substrate inhibition, which is CLINICAL RESEARCH: or other steroidal and non-steroidal suicide inhibitors. The the mode of action through which other over the Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat structure- activity relationships mentioned are not counter aromatase inhibitors such as 6-OXO and ATD diet-induced obesity in mice comprehensive as there undoubtedly exists additional work. Competitive inhibition offers a more short term There is a critical need for new mechanism-of-action drugs that primary amine substitutions displayed high permeability from structural manipulations that occur to further enhance solution to estrogen control, as aromatase inhibition only reduce the burden of obesity and associated chronic metabolic passive and active transport across membranes. Importantly, aromatase anity. Therefore, it is NOT an appropriate occurs while Desoxy DHEA is present in the body. Desoxy comorbidities. A potentially novel target to treat obesity and type methylquinolinium analogues displayed high selectivity, not replacement to prescription compounds when heavy DHEA is a relatively quickly metabolized compound. So 2 diabetes is nicotinamide-N-methyltransferase (NNMT), a inhibiting related SAM-dependent methyltransferases or enzymes aromatase inhibition is required. It does however, offer a with Desoxy DHEA Tailor Made offers you a new option cytosolic enzyme with newly identified roles in cellular in the NAD+ salvage pathway. NNMT inhibitors reduced cost-effective, safe, and legal method of estrogen for estrogen control. metabolism and energy homeostasis. To validate NNMT as an intracellular 1-MNA, increased intracellular NAD+ and management as validated by independent lab tests and anti-obesity drug target, we investigated the permeability, selectiv- S-(5’-adenosyl)-L-methionine (SAM), and suppressed lipogenesis ity, mechanistic, and physiological properties of a series of small in adipocytes. Treatment of diet-induced obese mice molecule NNMT inhibitors. Membrane permeability of NNMT systemically with a potent NNMT inhibitor significantly reduced Ben Esgro, BS,CSCS,CISS inhibitors was characterized using parallel artificial body weight and white adipose mass, decreased adipocyte size, A full copy of all trials are available from Tailor Made Compounding Pharmacy. Please contact us for more info. membrane permeability and Caco-2 cell assays. Selectivity was and lowered plasma total cholesterol levels. Notably, tested against structurally-related methyltransferases and administration of NNMT inhibitors did not impact total food nicotinamide adenine dinucleotide (NAD+) salvage pathway intake nor produce any observable adverse effects. These results enzymes. Effects of NNMT inhibitors on lipogenesis and support development of small molecule NNMT inhibitors as intracellular levels of metabolites, including NNMT reaction therapeutics to reverse diet-induced obesity and validate NNMT product 1- methylnicotinamide (1-MNA) were evaluated in as a viable target to treat obesity and related metabolic cultured adipocytes. Effects of a potent NNMT inhibitor on conditions. Increased flux of key cellular energy regulators, obesity measures and plasma lipid were assessed in diet-induced including NAD+and SAM, may potentially define the therapeutic obese mice fed a high-fat diet. Methylquinolinium scaffolds with mechanism-of-action of NNMT inhibitors. Harshini Neelakantan, Virginia Vance, Michael D. Wetzel, Hua-Yu Leo Wang, Stanton F.
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