Safety Data Sheet: Benzylamine
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02/06/2019 12:05 PM Appendix 3745-21-09 Appendix A
ACTION: Final EXISTING DATE: 02/06/2019 12:05 PM Appendix 3745-21-09 Appendix A List of Organic Chemicals for which Paragraphs (DD) and (EE) of Rule 3745-21-09 of the Administrative Code are Applicable Organic Chemical Organic Chemical Acetal Benzaldehyde Acetaldehyde Benzamide Acetaldol Benzene Acetamide Benzenedisulfonic acid Acetanilide Benzenesulfonic acid Acetic acid Benzil Acetic Anhydride Benzilic acid Acetone Benzoic acid Acetone cyanohydrin Benzoin Acetonitrile Benzonitrile Acetophenone Benzophenone Acetyl chloride Benzotrichloride Acetylene Benzoyl chloride Acrolein Benzyl alcohol Acrylamide Benzylamine Acrylic acid Benzyl benzoate Acrylonitrile Benzyl chloride Adipic acid Benzyl dichloride Adiponitrile Biphenyl Alkyl naphthalenes Bisphenol A Allyl alcohol Bromobenzene Allyl chloride Bromonaphthalene Aminobenzoic acid Butadiene Aminoethylethanolamine 1-butene p-aminophenol n-butyl acetate Amyl acetates n-butyl acrylate Amyl alcohols n-butyl alcohol Amyl amine s-butyl alcohol Amyl chloride t-butyl alcohol Amyl mercaptans n-butylamine Amyl phenol s-butylamine Aniline t-butylamine Aniline hydrochloride p-tertbutyl benzoic acid Anisidine 1,3-butylene glycol Anisole n-butyraldehyde Anthranilic acid Butyric acid Anthraquinone Butyric anhydride Butyronitrile Caprolactam APPENDIX p(183930) pa(324943) d: (715700) ra(553210) print date: 02/06/2019 12:05 PM 3745-21-09, Appendix A 2 Carbon disulfide Cyclohexene Carbon tetrabromide Cyclohexylamine Carbon tetrachloride Cyclooctadiene Cellulose acetate Decanol Chloroacetic acid Diacetone alcohol -
United States Patent Office Patented May 16, 1967 2 3,320,314 125 C
3,320,314 United States Patent Office Patented May 16, 1967 2 3,320,314 125 C. Agitation may be employed during the reaction, CHLOROBENZYL SULFAMDES but none is required. William J. Houlihan, Mountain Lakes, N.J., assignor to The tertiary amine medium provides a solvent system Sandoz Inc., Hanover, N.J. in which the reaction takes place. Contemplated tertiary No Drawing. Filled June 15, 1964, Ser. No. 375,288 5 amines include, for example, tri(lower) alkylamines, e.g. 6 Claims. (C. 260-556) triethylamine; (lower) alkyl pyrroles, e.g. N-propyl-pyr This application is a continuation-in-part of application role; pyridine; (lower) alkyl pyridines, e.g. 3-ethyl pyri Ser. No. 339,354, filed on Jan. 22, 1964, and now aban dine; (lower) alkoxy pyridines, e.g. 2,5-dimethoxypyri doned. dine; quinoline; (lower) alkyl quinolines, e.g. 8-ethyl O quinoline; N-(lower) alkyl morpholine, e.g. N-methyl This invention is directed to two groups of benzyl sulf morpholine; and N,N'-di(lower) alkyl piperazine, e.g. amides having one or more chlorine substituents on the N-methyl,N'-ethyl-piperazine. sole aromatic ring. These groups are, respectively, of For the preparation of Compounds II wherein R6 is a the formulae hydrogen atom similar reaction conditions are employed; R1 a primary benzyl amine (V) is substituted for the sec ondary benzyl amine (III), and the reaction medium is an R2- ceN seNH aqueous ethanolic medium: R R3- -H 20 R1 R4 (I) and R2- ot NH R1 -- (IV) - (II) -- NH3 R3 -Rs R' ce ise 25 R2- N NEI k (B) R6 R3 -R5 (V) RA (II) 30 wherein In both reaction (A) and reaction (B) each of R, R, R is either lower alkyl having two or more carbon atoms R, R3, R, R5 and R6 has its above-ascribed meaning. -
Hydrogenation of Benzonitrile Over Supported Pd Catalysts: Kinetic and Mechanistic Insight Mairi I
This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. Article Cite This: Org. Process Res. Dev. 2019, 23, 977−989 pubs.acs.org/OPRD Hydrogenation of Benzonitrile over Supported Pd Catalysts: Kinetic and Mechanistic Insight Mairi I. McAllister,† Cedrić Boulho,† Lauren F. Gilpin,† Liam McMillan,† Colin Brennan,‡ and David Lennon*,† † School of Chemistry, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, U.K. ‡ Syngenta, Jeallot’s Hill International Research Centre, Berkshire RG42 6EY, U.K. ABSTRACT: The liquid phase hydrogenation of benzonitrile over a 5 wt % Pd/C catalyst using a stirred autoclave is investigated. The reaction conforms to a consecutive reaction sequence: first benzonitrile is hydrogenated to produce benzylamine, which subsequently undergoes a hydrogenolysis step to form toluene. Benzonitrile hydrogenation obeys first-order kinetics with an activation energy of 27.6 kJ mol−1. In contrast, the benzylamine hydrogenolysis stage obeys zero-order kinetics −1 and exhibits an activation energy of 80.1 kJ mol . A 1 wt % Pd/Al2O3 catalyst is additionally examined, which is also seen to support hydrogenolysis activity alongside the hydrogenation pathway. Gas phase transmission infrared spectroscopic measurements of the hydrogenation of benzonitrile and benzylamine over the 1 wt % Pd/Al2O3 catalyst utilizing hydrogen and deuterium are undertaken, which enable reaction schemes incorporating adsorption geometries of intermediate adsorption complexes to be proposed. KEYWORDS: nitrile hydrogenation, carbon-supported palladium, hydrogenolysis, benzonitrile, benzylamine 1. INTRODUCTION selectivity (95%).12 The high selectivity toward the primary Primary aromatic amines represent an important class of amine was obtained under mild conditions (303 K, 6 bar H2) chemicals with widespread application in many areas of the in the presence of an acid additive. -
Further Studies on the Synthesis Of
FURTHER STUDIES ON THE SYNTHESIS OF ARYLETHMOLMINES By Robert Simonoff in Thesis submitted to the Faculty of the Graduate School of the University of Maryland in partial fulfillment of the requirements for the degree of Doctor of Philosophy 1945 UMI Number: DP70015 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. UMI Dissertation Publishing UMI DP70015 Published by ProQuest LLC (2015). Copyright in the Dissertation held by the Author. Microform Edition © ProQuest LLC. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code ProQuest ProQuest LLC. 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106- 1346 ACKNOWLEDGEMENT The author wishes to express his appreciation for the encouragement and assistance given by Dr, Walter H. Hartung under whose direction this work has been carried out* TABLE OF CONTENTS Page INTRODUCTION.................................................... 1 REVIEW OF THE LITERATURE Previous Methods of Synthesis of Arylethanolamines Hydrogenolytic Debenzylation. ................. ......17 EXPERIMENTAL Synthesis of Ketones .................... .33 Synthesis of Amines.......... ........ ......... ....... ....... 38 Nitrosation of Ketones.• •«••••••.......... 40 Decomposition of Arylglyoxylohydroxamyl -
Bis(Benzylamine) Monomers: One-Pot Preparation and Application in Dendrimer Scaffolds for Removing Pyrene from Aqueous Environments
Supporting Information for Bis(benzylamine) monomers: One-pot preparation and application in dendrimer scaffolds for removing pyrene from aqueous environments Olivia N. Monaco, Sarah C. Tomas, Meghan K. Kirrane and Amy M. Balija* Address: Department of Chemistry, Fordham University, 441 E. Fordham Road, Bronx, NY 10458, United States Email: Amy M. Balija* - [email protected] *Corresponding author Full experimental synthetic procedures for compounds 3a–g, 4a–h,6–8, and 11–13, and pyrene fluorescence spectral data Table of contents: I. General experimental II. Synthesis of bisimine compounds 3 III. Synthesis of bisamine compounds 4 IV. Synthesis of dendrimers 6, 11–13 V. Thin film fluorescence experiments VI. Calculations of inclusion formation constants, Gibbs free energies, and dendrimer capacities VII. Representative 1H and 13C NMR spectral data VIII. References I. General experimental All reactions were performed under an argon gas atmosphere with either flame-dried or oven-dried glassware unless otherwise noted. Reagents were obtained from Aldrich or TCI America. 2-(Dimethylamino)pyridinium p-toluenesulfonate (DPTS) was synthesized as reported previously [1]. Solvents and reagents were used without further purification except for the following: MeOH was distilled from CaSO4, CH2Cl2 was distilled from CaH2, benzaldehyde was distilled neat, and phloroglucinol dihydrate was azeotroped 5 times with toluene prior to use. Reactions were monitored by thin layer chromatography (TLC) using silica gel 60 F254 glass plates. TLC bands were visualized by UV and phosphomolybdic acid (PMA) stain. Eluent solvent ratios are reported in v/v. Size exclusion chromatography was performed using a 2 cm x 50 cm column of Bio-Rad Bio- Beads S-X1 beads (200–400 mesh) in toluene. -
Dissociation Constants of Organic Acids and Bases
DISSOCIATION CONSTANTS OF ORGANIC ACIDS AND BASES This table lists the dissociation (ionization) constants of over pKa + pKb = pKwater = 14.00 (at 25°C) 1070 organic acids, bases, and amphoteric compounds. All data apply to dilute aqueous solutions and are presented as values of Compounds are listed by molecular formula in Hill order. pKa, which is defined as the negative of the logarithm of the equi- librium constant K for the reaction a References HA H+ + A- 1. Perrin, D. D., Dissociation Constants of Organic Bases in Aqueous i.e., Solution, Butterworths, London, 1965; Supplement, 1972. 2. Serjeant, E. P., and Dempsey, B., Ionization Constants of Organic Acids + - Ka = [H ][A ]/[HA] in Aqueous Solution, Pergamon, Oxford, 1979. 3. Albert, A., “Ionization Constants of Heterocyclic Substances”, in where [H+], etc. represent the concentrations of the respective Katritzky, A. R., Ed., Physical Methods in Heterocyclic Chemistry, - species in mol/L. It follows that pKa = pH + log[HA] – log[A ], so Academic Press, New York, 1963. 4. Sober, H.A., Ed., CRC Handbook of Biochemistry, CRC Press, Boca that a solution with 50% dissociation has pH equal to the pKa of the acid. Raton, FL, 1968. 5. Perrin, D. D., Dempsey, B., and Serjeant, E. P., pK Prediction for Data for bases are presented as pK values for the conjugate acid, a a Organic Acids and Bases, Chapman and Hall, London, 1981. i.e., for the reaction 6. Albert, A., and Serjeant, E. P., The Determination of Ionization + + Constants, Third Edition, Chapman and Hall, London, 1984. BH H + B 7. Budavari, S., Ed., The Merck Index, Twelth Edition, Merck & Co., Whitehouse Station, NJ, 1996. -
Supporting Information Top-Down Fabrication of Crystalline Metal
Electronic Supplementary Material (ESI) for Chemical Communications This journal is © The Royal Society of Chemistry 2011 Supporting Information Top-down fabrication of crystalline metal-organic framework nanosheets Pei-Zhou Li,a,b Yasushi Maedaa and Qiang Xu*a,b aNational Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577, Japan. Fax: +81-72-751-9629; Tel: +81-72-751-9562; E-mail: [email protected] bGraduate School of Engineering, Kobe University, Nada Ku, Kobe, Hyogo 657-8501, Japan Experimental section General All the reagents and solvents employed were commercially available and used without further purification. All the experiment were carried out in the laboratory atmosphere at room temperature (20 – 30 °C). FT-IR spectra were recorded on a BIORAD FTS-6000e spectrometer. Thermogravimetric analyses (TGA) were carried out at a ramp rate of 5 °C/min from room temperature to 600 °C under helium atmosphere on a Shimadzu DTG-50 instrument. Powder X-ray diffraction (XRD) measurements were performed on a Rigaku 2000 diffractometer at 40 kV and 40 mA with Cu Kα radiation (λ = 1.5406 Å). Scanning electron microscopy (SEM) measurements were performed on a Hitachi S-5000 SEM instrument. Atom force microscope (AFM) measurements were performed on a SPA-300 (SII Nanotechnology) AFM instrument. Preparation of the bulk crystals of MOF-2 Zn(NO3)2·4H2O (0.262 g, 1.0 mmol) and terephthalic acid (TPA, 0.166 g, 1.0 mmol) were dissolved in N,N-dimethylformamide (DMF, 10 mL). After solvo-thermal reaction at 105 °C for 24 hours in a Teflon-Steel autoclave, the most part of the mother-liquid was discarded and the mother-liquid soaked crystals were moved into a petri dish and diffused by distilled water at 45 oC for 4 hours. -
Acid-Base Equilibrium Constants for the Reaction of Tribenzylamine with Picric Acid and with Trinitro-M Cresol in Benzene, from Spectrophotometric Data
U. S. Department of Commerce Research Paper RP1997 National Bureau of Standards Volume 42, June 1949 Part of the Journal of Research of the National Bureau of Standards ·Acid-Base Equilibrium Constants for the Reaction of Tribenzylamine with Picric Acid and with Trinitro-m Cresol in Benzene, from Spectrophotometric Data By Marion Maclean Davis and E. Anne McDonald The relative acidic strengths ~ o f picric acid and t rinitro-m-cresol in benzene have been measured spectrophotometrically in terms of their reactivity with the base, t ribenzylamine. The respective constants found for the combinat ion of tribenzylamine with picric acid and with trinitro-m-cresol in benzene=a t 25° Care 1.58X 103 and 4.48 X 102• The same relative order of strengths would be predicted on theoretical grounds. The constant for picric acid is in close agreement wi th previous measurements of the dielectric constant of benzene solutions of t ribenzylammonium picrate. The method used for assessment of the relat ive strengths of the two 'acids is superior:to measurements of their ionic dissociation in water. 1. Introduction as both dono)' and acccptor. But whencvcr the solvent displays aciclic or basic character, the During Lhe first quarter of this century, the nat.ure of the reaction between a dissolved acid definitions of an acid and a base most commonly and base is partially masked. The id eal condi taught and applied were founded on the behavior tion for studying the reaction between an acid of aqueous soluLions. As is well known, acidic and ft base would be to u e no solvent at all. -
Oxidative Coupling of Benzylamines Into JV-Benzylbenzaldimines with Mntppcl/Z-Buooh
1600 Bull. Korean Chem. Soc. 2005, Vol. 26, No. 10 Notes Oxidative Coupling of Benzylamines into JV-Benzylbenzaldimines with MnTPPCl/Z-BuOOH Sung Soo Kim* and Santosh S. Thakura Department of Chemistry, Inha University Incheon 402-751, Korea. ^E-mail: sungsoo@inha. ac. kr Received April 15, 2005 Key Words : Benzylamines, jV-Benzylbenzaldimine, Electron transfer, Deprotonation, Coupling Mn(III)-based oxidative free radical cyclizations and follow similar 아 eps of reaction to those of reference 11. annulations have been extensively iiive아 igated,' The rate Mn(III) ion of MnTPPCl may make a complex with determining step in the oxidation of acetic acid by TBHP to give Mn(V)=O that may provoke electron transfer Mn(OAc)3 involves an oxo-centered trian이 e ofMn(III) with from benzylamine forming aminium cation, C6H5CH2NH2 bridging acetates,2 1. The loss of a proton from 1 gives 23 5. 5 becomes acidic enough to expel benzylic proton that undergoes rapid electron transfer to the oxo-centered to produce C6H5CH-NH2 6 that is oxidized by Mn(IV) metal system forming 3.3 adds to the alkene to produce 4 with formation of C6H5CH=NH고 7. Benzaldehyde might (Scheme 1). result from hydrolysis of 7. However our control experiment Benzylamine has been catalytically transformed into N- at sub-zero temperature shows no trace of benzaldehyde benzylbenzaldimine 8 via various pathways.4-7 3-Methyl- (aldehydic proton: S= 10 ppm) but indicates instead gradual umiflavin4 promotes conversion of C6H5CH2NH? to 8 under increase of benzylic hydrogen of 8 (benzylic proton : 8 = acid catalyzed thermal conditions. -
Equilibrium Constants for the Formation of Silver
EQUILIBRIUM CONSTANTS FOR THE FORMATION OF SILVER AMMINES IN ETHANOL-WATER MIXTURES DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Charles Thomas Anderson, A.B ****** The Ohio State University Approved by* Adviser Department of Chemistry .•■--•.sia-ji • c--.\'--~t ' -.- ■?-..-_ _ _ _ _ __ ACKNOWLEDGMENT I -wish to express my deep appreciation to my preoeptor. Professor Prank Verhoek, for suggesting this problem, and for his advice and encouragement during the course of the work. 1 also wish to thank the Cincinnati Chemical Works for providing a fellowship under which much of this work was done. ii PREFACE This dissertation is & report of experimental studies on the equilibrium constants of a number of silver ammine complexes in ethanol-water solution, with the purpose of examining the relation ship between the stabilities of these complexes and the basio strengths and structures of the amines. Formation constants of the complex silver ions and dissociation constants of the amines were obtained at 25°C in 50 mole % ethanol-water mixtures from pH measurements of solutions containing known amounts of silver ion, acid, amine and neutral salt. The glass eleotrode used was calibrated on solutions for which the pH had been determined by potentiometric measurements with hydrogen electrodes and by spectrophotometric measurements using an indicator. - iii - TABLE OF CONTENTS ACKNOWLEDGMENT ....................................... ii PREFACE............................................... iii LIST OF T A B L E S ......................................... vi LIST OF ILLUSTRATIONS................................... ix LIST OF AMINES (ALPHABETICAL).......................... x LIST OF AMINES (BY NUMBER SYMBOL)........................ xi I. -
Selective Production of Benzylamine Via Gas Phase Hydrogenation of Benzonitrile Over Supported Pd Catalysts
Heriot-Watt University Research Gateway Selective production of benzylamine via gas phase hydrogenation of benzonitrile over supported Pd catalysts Citation for published version: Hao, Y, Li, M, Cárdenas-Lizana, F & Keane, MA 2016, 'Selective production of benzylamine via gas phase hydrogenation of benzonitrile over supported Pd catalysts', Catalysis Letters, vol. 146, no. 1, pp. 109-116. https://doi.org/10.1007/s10562-015-1655-8 Digital Object Identifier (DOI): 10.1007/s10562-015-1655-8 Link: Link to publication record in Heriot-Watt Research Portal Document Version: Peer reviewed version Published In: Catalysis Letters General rights Copyright for the publications made accessible via Heriot-Watt Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy Heriot-Watt University has made every reasonable effort to ensure that the content in Heriot-Watt Research Portal complies with UK legislation. If you believe that the public display of this file breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Download date: 27. Sep. 2021 Selective Production of Benzylamine via Gas Phase Hydrogenation of Benzonitrile over Supported Pd Catalysts Yufen Hao, Maoshuai Li, Fernando Cárdenas-Lizana and Mark A. Keane* Chemical Engineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, Scotland *corresponding author: e-mail: [email protected]; tel.: +44(0)131 451 4719 e-mail: [email protected] e-mail: [email protected] e-mail: [email protected] 1 Abstract The continuous gas phase hydrogenation of benzonitrile has been studied over Pd/C and Pd/Al2O3 (mean Pd size = 2.5-3.0 nm from STEM). -
Safety Data Sheet
SAFETY DATA SHEET Revision Date 26-Feb-2021 Revision Number 2 SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1. Product identifier Product Description: 3-Fluoro-2-(trifluoromethyl)benzylamine Cat No. : H32210 CAS-No 771581-62-5 Molecular Formula C8 H7 F4 N 1.2. Relevant identified uses of the substance or mixture and uses advised against Recommended Use Laboratory chemicals. Uses advised against No Information available 1.3. Details of the supplier of the safety data sheet Company Thermo Fisher (Kandel) GmbH . Erlenbachweg 2 76870 Kandel Germany Tel: +49 (0) 721 84007 280 Fax: +49 (0) 721 84007 300 E-mail address [email protected] www.alfa.com Product safety Tel + +049 (0) 7275 988687-0 1.4. Emergency telephone number Carechem 24: +44 (0) 1235 239 670 (Multi-language emergency number) Poison Information Center Mainz www.giftinfo.uni-mainz.de Telephone: +49(0)6131/19240 Exclusively for customers in Austria: Poison Information Center (VIZ) Emergency call 0-24 clock: +43 1 406 43 43 Office hours: Monday to Friday, 8am to 4pm, tel: +43 1 406 68 98 SECTION 2: HAZARDS IDENTIFICATION 2.1. Classification of the substance or mixture CLP Classification - Regulation (EC) No 1272/2008 Physical hazards Based on available data, the classification criteria are not met ______________________________________________________________________________________________ ALFAAH32210 Page 1 / 10 SAFETY DATA SHEET 3-Fluoro-2-(trifluoromethyl)benzylamine Revision Date 26-Feb-2021 ______________________________________________________________________________________________ Health hazards Skin Corrosion/Irritation Category 1 C (H314) Serious Eye Damage/Eye Irritation Category 1 (H318) Environmental hazards Based on available data, the classification criteria are not met Full text of Hazard Statements: see section 16 2.2.