(12) United States Patent (10) Patent No.: US 6,586,617 B1 Tabuchi Et Al
USOO65866.17B1 (12) United States Patent (10) Patent No.: US 6,586,617 B1 Tabuchi et al. (45) Date of Patent: Jul. 1, 2003 (54) SULFONAMIDE DERIVATIVES JP 63-307851 12/1988 JP 1-156952 6/1989 (75) Inventors: Takanori Tabuchi, Tsukuba (JP); WO 96/36596 11/1996 WO 97/24135 7/1997 Tetsuhiro Yamamoto, Toride (JP); WO 97/31910 9/1997 Masaharu Nakayama, Tsukuba (JP) WO 98/45.255 10/1998 (73) Assignee: Sumitomo Chemical Takeda Agro WO 99/06037 2/1999 Company, Limited, Tokyo (JP) WO OO/50391 8/2000 OTHER PUBLICATIONS (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 Derek R. Buckle et al., “Inhibition of Cyclic Nucleotide U.S.C. 154(b) by 0 days. Phosphodiesterase by Derivatives of 1,3-Bis(cyclopropyl methyl)xanthine”, J. Med. Chem., vol. 37, No. 4, pp. (21) Appl. No.: 09/958,953 476-485, 1994. (22) PCT Filed: Apr. 17, 2000 Francisca Lopes et al., “Acyloxymethyl as a Drug Protecting Group. Part 6: N-Acyloxymethyl- and N-Aminocarbony (86) PCT No.: PCT/JP00/02764 loxy)methylsulfonamides as Prodrugs of Agents Contain S371 (c)(1), ing a Secondary Sulfonamide Group”, Bioorganic & (2), (4) Date: Dec. 18, 2001 Medicinal Chemistry, vol. 8, No. 4, pp. 707-716, 2000. J.S. Sukla et al., “Studies on Some Newer Possible Biologi (87) PCT Pub. No.: WO00/65913 cally Active Agents: Part II. Synthesis of N-(-aminopropyl)-2-heterocyclic-p-arylidene aminoben PCT Pub. Date: Nov. 9, 2000 ZeneSulphonamides and N(-aminopropyl)-2-heterocyclic (30) Foreign Application Priority Data Sulphanalamides and their Antibacterial Activity, J.
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