FMO5 Antibody Cat. No.: 60-965

FMO5 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

This FMO5 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 474-502 amino acids from the C-terminal region of human FMO5.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 60 kDa WEIGHT:

Properties

This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

September 29, 2021 1 https://www.prosci-inc.com/fmo5-antibody-60-965.html PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: FMO5

Dimethylaniline monooxygenase [N-oxide-forming] 5, Dimethylaniline oxidase 5, Hepatic ALTERNATE NAMES: flavin-containing monooxygenase 5, FMO 5, FMO5

ACCESSION NO.: P49326

PROTEIN GI NO.: 1346021

GENE ID: 2330

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in BACKGROUND: fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.

REFERENCES: 1) Rose, J. Phd, et al. Mol. Med. (2010) In press :

2) Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)

3) Wheeler, H.E., et al. PLoS Genet.(10), E1000685 (2009) :

4) Zhang, J., et al. Drug Metab. Dispos. 34(1):19-26(2006)

ANTIBODIES FOR RESEARCH USE ONLY.

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