Geophysical Anomalies Detected by Electrical Resistivity Tomography in the Area Surrounding Tutankhamun's Tomb
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Kv2 Dysfunction After Peripheral Axotomy Enhances Sensory Neuron
Our reference: YEXNR 11584 P-authorquery-v11 AUTHOR QUERY FORM Journal: YEXNR Please e-mail or fax your responses and any corrections to: Bennett, Timothy E-mail: [email protected] Fax: +1 619 699 6721 Article Number: 11584 Dear Author, Please check your proof carefully and mark all corrections at the appropriate place in the proof (e.g., by using on-screen annotation in the PDF file) or compile them in a separate list. Note: if you opt to annotate the file with software other than Adobe Reader then please also highlight the appropriate place in the PDF file. To ensure fast publication of your paper please return your corrections within 48 hours. For correction or revision of any artwork, please consult http://www.elsevier.com/artworkinstructions. Any queries or remarks that have arisen during the processing of your manuscript are listed below and highlighted by flags in the proof. Click on the ‘Q’ link to go to the location in the proof. Location in article Query / Remark: click on the Q link to go Please insert your reply or correction at the corresponding line in the proof Q1 Please confirm that given names and surnames have been identified correctly. Q2 Please check the layout of Table 5, and correct if necessary. Q3 A dummy footnote citation of footnote [**] has been inserted as a corresponding footnote text has been provided. Please check if the placement is correct and amend if necessary. Q4, Q5 This sentence has been slightly modified for clarity. Please check that the meaning is still correct, and amend if necessary. -
2012: Providence, Rhode Island
The 63rd Annual Meeting of the American Research Center in Egypt April 27-29, 2012 Renaissance Providence Hotel Providence, RI Photo Credits Front cover: Egyptian, Late Period, Saite, Dynasty 26 (ca. 664-525 BCE) Ritual rattle Glassy faience; h. 7 1/8 in Helen M. Danforth Acquisition Fund 1995.050 Museum of Art Rhode Island School of Design, Providence Photography by Erik Gould, courtesy of the Museum of Art, Rhode Island School of Design, Providence. Photo spread pages 6-7: Conservation of Euergates Gate Photo: Owen Murray Photo page 13: The late Luigi De Cesaris conserving paintings at the Red Monastery in 2011. Luigi dedicated himself with enormous energy to the suc- cess of ARCE’s work in cultural heritage preservation. He died in Sohag on December 19, 2011. With his death, Egypt has lost a highly skilled conservator and ARCE a committed colleague as well as a devoted friend. Photo: Elizabeth Bolman Abstracts title page 14: Detail of relief on Euergates Gate at Karnak Photo: Owen Murray Some of the images used in this year’s Annual Meeting Program Booklet are taken from ARCE conservation projects in Egypt which are funded by grants from the United States Agency for International Development (USAID). The Chronique d’Égypte has been published annually every year since 1925 by the Association Égyptologique Reine Élisabeth. It was originally a newsletter but rapidly became an international scientific journal. In addition to articles on various aspects of Egyptology, papyrology and coptology (philology, history, archaeology and history of art), it also contains critical reviews of recently published books. -
The Work of the Theban Mapping Project by Kent Weeks Saturday, January 30, 2021
Virtual Lecture Transcript: Does the Past Have a Future? The Work of the Theban Mapping Project By Kent Weeks Saturday, January 30, 2021 David A. Anderson: Well, hello, everyone, and welcome to the third of our January public lecture series. I'm Dr. David Anderson, the vice president of the board of governors of ARCE, and I want to welcome you to a very special lecture today with Dr. Kent Weeks titled, Does the Past Have a Future: The Work of the Theban Mapping Project. This lecture is celebrating the work of the Theban Mapping Project as well as the launch of the new Theban Mapping Project website, www.thebanmappingproject.com. Before we introduce Dr. Weeks, for those of you who are new to ARCE, we are a private nonprofit organization whose mission is to support the research on all aspects of Egyptian history and culture, foster a broader knowledge about Egypt among the general public and to support American- Egyptian cultural ties. As a nonprofit, we rely on ARCE members to support our work, so I want to first give a special welcome to our ARCE members who are joining us today. If you are not already a member and are interested in becoming one, I invite you to visit our website arce.org and join online to learn more about the organization and the important work that all of our members are doing. We provide a suite of benefits to our members including private members-only lecture series. Our next members-only lecture is on February 6th at 1 p.m. -
Protective Zika Vaccines Engineered to Eliminate Enhancement of Dengue Infection Via Immunodominance Switch
ARTICLES https://doi.org/10.1038/s41590-021-00966-6 Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch Lianpan Dai 1,2,3,8 ✉ , Kun Xu3,8, Jinhe Li2,4,8, Qingrui Huang5, Jian Song 1, Yuxuan Han2, Tianyi Zheng2,4, Ping Gao2,4, Xuancheng Lu6, Huabing Yang 5, Kefang Liu7, Qianfeng Xia3, Qihui Wang 1, Yan Chai1, Jianxun Qi 1, Jinghua Yan 5 ✉ and George F. Gao 1,2,4 ✉ Antibody-dependent enhancement (ADE) is an important safety concern for vaccine development against dengue virus (DENV) and its antigenically related Zika virus (ZIKV) because vaccine may prime deleterious antibodies to enhance natural infections. Cross-reactive antibodies targeting the conserved fusion loop epitope (FLE) are known as the main sources of ADE. We design ZIKV immunogens engineered to change the FLE conformation but preserve neutralizing epitopes. Single vaccination conferred sterilizing immunity against ZIKV without ADE of DENV-serotype 1–4 infections and abrogated maternal–neonatal transmis- sion in mice. Unlike the wild-type-based vaccine inducing predominately cross-reactive ADE-prone antibodies, B cell profiling revealed that the engineered vaccines switched immunodominance to dispersed patterns without DENV enhancement. The crystal structure of the engineered immunogen showed the dimeric conformation of the envelope protein with FLE disruption. We provide vaccine candidates that will prevent both ZIKV infection and infection-/vaccination-induced DENV ADE. IKV is a mosquito-borne pathogen belonging to the genus models12,13,19,20. More importantly, a recent study of pediatric cohorts Flavivirus in the family Flaviviridae1. The 2015–2016 ZIKV in Nicaragua clearly shows that previous ZIKV infection enhanced epidemic spread to 84 countries worldwide, including future risk of DENV2 disease and severity, as well as DENV3 sever- Z2,3 21,22 China . -
This Pdf of Your Paper in Current Research in Egyptology 2014 Belongs to the Publishers Oxbow Books and It Is Their Copyright
This pdf of your paper in Current Research in Egyptology 2014 belongs to the publishers Oxbow Books and it is their copyright. As author you are licenced to make up to 50 offprints from it, but beyond that you may not publish it on the World Wide Web until three years from publication (April 2018), unless the site is a limited access intranet (password protected). If you have queries about this please contact the editorial department at Oxbow Books (editorial@ oxbowbooks.com). An offprint from CURRENT RESEARCH IN EGYPTOLOGY 2014 Proceedings of the Fifteenth Annual Symposium University College London and King’s College London April 9–12, 2014 edited by Massimiliano S. Pinarello, Justin Yoo, Jason Lundock and Carl Walsh Paperback Edition: ISBN 978-1-78570-046-0 Digital Edition: ISBN 978-1-78570-047-7 © Oxbow Books 2015 Oxford & Philadelphia www.oxbowbooks.com Published in the United Kingdom in 2015 by OXBOW BOOKS 10 Hythe Bridge Street, Oxford OX1 2EW and in the United States by OXBOW BOOKS 908 Darby Road, Havertown, PA 19083 © Oxbow Books and the individual contributors 2015 Paperback Edition: ISBN 978-1-78570-046-0 Digital Edition: ISBN 978-1-78570-047-7 A CIP record for this book is available from the British Library All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical including photocopying, recording or by any information storage and retrieval system, without permission from the publisher in writing. For a complete list of Oxbow titles, please contact: UNITED KINGDOM UNITED STATES OF AMERICA Oxbow Books Oxbow Books Telephone (01865) 241249, Fax (01865) 794449 Telephone (800) 791-9354, Fax (610) 853-9146 Email: [email protected] Email: [email protected] www.oxbowbooks.com www.casemateacademic.com/oxbow Oxbow Books is part of the Casemate Group Front cover: Original Artwork by Isabel Zemani, © Isabel Zemani. -
Subunits Identified in the Human Genome
Obligatory heterotetramerization of three previously uncharacterized Kv channel ␣-subunits identified in the human genome N. Ottschytsch, A. Raes, D. Van Hoorick, and D. J. Snyders* Laboratory for Molecular Biophysics, Physiology, and Pharmacology, University of Antwerp (UIA) and Flanders Institute for Biotechnology (VIB), B2610 Antwerp, Belgium Edited by Lily Y. Jan, University of California School of Medicine, San Francisco, CA, and approved April 12, 2002 (received for review November 20, 2001) Voltage-gated K؉ channels control excitability in neuronal and sense, these ‘‘silent’’ subunits can be considered regulatory various other tissues. We identified three unique ␣-subunits of subunits—e.g., the metabolic regulation of the Kv2.1͞Kv9.3 -voltage-gated K؉-channels in the human genome. Analysis of the heteromultimer might play an important role in hypoxic pulmo full-length sequences indicated that one represents a previously nary artery vasoconstriction and in the possible development of uncharacterized member of the Kv6 subfamily, Kv6.3, whereas the pulmonary hypertension (8). others are the first members of two unique subfamilies, Kv10.1 and In this study we report the cloning and functional properties Kv11.1. Although they have all of the hallmarks of voltage-gated of three previously uncharacterized subunits that were identified K؉ channel subunits, they did not produce K؉ currents when in the early public draft version of the human genome. Based on expressed in mammalian cells. Confocal microscopy showed that sequence identity, one of these is a previously uncharacterized Kv6.3, Kv10.1, and Kv11.1 alone did not reach the plasma mem- member of the Kv6 subfamily (Kv6.3), whereas the others are the brane, but were retained in the endoplasmic reticulum. -
On the Modeling of Air Flow in the Tombs of the Valley of Kings
cs: O ani pe ch n e A c M c Khalil, Fluid Mech Open Acc 2017, 4:3 d e i s u s l F Fluid Mechanics: Open Access DOI: 10.4172/2476-2296.1000166 ISSN: 2476-2296 Research Article Open Access On the Modeling of Air Flow in the Tombs of the Valley of Kings Essam E Khalil1,2* 1Chairman Arab HVAC Code Committee ASHRAE Director-At-Large, USA, Convenor ISO TC205 WG2, Co-Convenor ISO TC163 WG4, Deputy Director (International) AIAA, USA 2DIC, Professor of Mechanical Engineering, Cairo University, Cairo, Egypt Abstract The tombs of the kings in Valley of the Kings, Luxor, are considered to be one of the tourism industry’s bases in Egypt due to their uniqueness all over the world. Hence, they should be preserved from the different factors that might cause harm for their wall paintings. One of these factors is the excessive relative humidity as it increases the bacteria and fungus activity inside the tomb in addition to its effect on the mechanical and physical properties of materials. This chapter describes the Research work to design ventilation systems to some of these important tombs. The chapter aims to investigate, design, and implement controlled climate to the tombs of the valley of kings with complete monitoring of air properties, temperature, relative humidity and carbon oxides and air quality parameters mechanical distributions inside selected tombs of the valley of the kings that are open for visitors. A complete climate control and monitoring of air will be effected with the aid of a mechanical ventilation system extracting air at designated locations in the wooden raised floor of the tombs. -
Ancient Egyptian Life Map for the Valley of the Kings
Ancient Egyptian Life Map for the Valley of the Kings The Valley of the Kings is where all the great pharaohs are buried. There is also the lesser known KV1 Valley of the Queens, where the wives, princes and princesses are buried, as well as some noble people. The Valley of the Kings is near the city of Thebes, now called Luxor. One of Napoleon Bonaparte’s expeditions came across the valley in 1799. Pharaoh Ramesses VII Since then, 63 different tombs have been found there. Some of them go down into the earth 650 feet. Most are richly adorned with paintings and carvings of life in Egypt and Egyptian beliefs of afterlife with the gods. The most famous tomb discovered was that of King Tutenkhamun. Compared to other tombs his was tiny, KV7 and it was undisturbed by grave robbers. Around the 18th dynasty Egyptians left Pharaoh Ramesses II behind building pyramids to carving tombs into the cliffsides of the valley. It is not known why the use of pyramids as burial tradition stopped. KV62 Some Egyptologists think that the valley was started by Queen Hatshepsut. Tutankhamun What do you think? What factors could affect a decision to abandon burying leaders and statesmen in pyramids, or, what might be the appeal of using the cliffs, if any? KV35 Amenhotep II was a succesful military leader during Egypt’s 18th dynasty. Pharaoh Amenhotep II King Tut ascended the throne still a child; his reign returned the country to polytheistic religion and away from his father’s institution of the one sun god. -
Minnowenvironmental Inc
--~------- minnowenvironmental inc. _____ 2 Lamb Street Georgetown, Ontario L7G 3M9 Memorandum To: Dan Cornett, Access Consulting Group From: Cynthia Russel, Minnow Environmental Inc. Date: February 13, 2008-02-13 Re: Update of Surface Water Quality Assessment for United Keno Hill Mine Complex. Minnow Environmental Inc. (Minnow) was retained by Access Consulting Group to undertake an assessment of the existing water quality data for the United Keno Hill Mine Complex (United Keno, Galena and Sourdough Hill). The objective of this assessment was to identify parameters and locations of concern within the downstream waters relative to established guidelines and background. This information, combined with toxicity data and watershed use objectives may then be combined to develop an approach for considering the development of Site Specific Water Quality Objectives (SSWQO) for various parameters and locations. In order to meet the study objectives, a progressive assessment of the available water quality data was undertaken which included the following steps; • Screen all data to identify outliers (i.e., those greater then 3 standard deviations from the mean) and remove these data. • Establish the background concentration for each parameter based the upper limit of background data distribution (mean + t S.D.) for the combined data from KV-1 and KV-37. UKH Surface Water Quality Assessment - Progress Report • Identify parameters with high method detection limits relative to guidelines which preclude determination of whether concentrations exceed the guideline. • Identify background concentrations which exceed the Canadian Water Quality Guidelines (CWQG). • Determine the median, mean, minimum and maximum concentration for each parameter at each location. • Determine which locations exceed background and/or CWQG at measurable (10%) and substantial (50%) frequencies. -
Heteromeric KV2/KV8.2 Channels Mediate Delayed Rectifier Potassium Currents in Primate Photoreceptors
3414 • The Journal of Neuroscience, April 4, 2018 • 38(14):3414–3427 Systems/Circuits Heteromeric KV2/KV8.2 Channels Mediate Delayed Rectifier Potassium Currents in Primate Photoreceptors Jacqueline Gayet-Primo,1 Daniel B. Yaeger,3 Roupen A. Khanjian,3 and XTeresa Puthussery1,2,3 1School of Optometry, 2Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, and 3Casey Eye Institute, Oregon Health & Science University, Portland, Oregon 97239 Silent voltage-gated potassium channel subunits (KVS) interact selectively with members of the KV2 channel family to modify their functional properties. The localization and functional roles of these silent subunits remain poorly understood. Mutations in the KVS subunit, KV8.2 (KCNV2), lead to severe visual impairment in humans, but the basis of these deficits remains unclear. Here, we examined the localization, native interactions, and functional properties of KV8.2-containing channels in mouse, macaque, and human photore- ceptors of either sex. In human retina, KV8.2 colocalized with KV2.1 and KV2.2 in cone inner segments and with KV2.1 in rod inner segments. KV2.1 and KV2.2 could be coimmunoprecipitated with KV8.2 in retinal lysates indicating that these subunits likely interact directly. Retinal KV2.1 was less phosphorylated than cortical KV2.1, a difference expected to alter the biophysical properties of these channels. Using voltage-clamp recordings and pharmacology, we provide functional evidence for Kv2-containing channels in primate rods and cones. We propose that the presence of KV8.2, and low levels of KV2.1 phosphorylation shift the activation range of KV2 channels toalignwiththeoperatingrangeofrodandconephotoreceptors.OurdataindicatearoleforKV2/KV8.2channelsinhumanphotoreceptor function and suggest that the visual deficits in patients with KCNV2 mutations arise from inadequate resting activation of KV channels in rod and cone inner segments. -
Expanding the Toolkit for Metabolic Engineering
Expanding the Toolkit for Metabolic Engineering Yao Zong (Andy) Ng Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Graduate School of Arts and Sciences COLUMBIA UNIVERSITY 2016 © 2016 Yao Zong (Andy) Ng All rights reserved ABSTRACT Expanding the Toolkit for Metabolic Engineering Yao Zong (Andy) Ng The essence of metabolic engineering is the modification of microbes for the overproduction of useful compounds. These cellular factories are increasingly recognized as an environmentally-friendly and cost-effective way to convert inexpensive and renewable feedstocks into products, compared to traditional chemical synthesis from petrochemicals. The products span the spectrum of specialty, fine or bulk chemicals, with uses such as pharmaceuticals, nutraceuticals, flavors and fragrances, agrochemicals, biofuels and building blocks for other compounds. However, the process of metabolic engineering can be long and expensive, primarily due to technological hurdles, our incomplete understanding of biology, as well as redundancies and limitations built into the natural program of living cells. Combinatorial or directed evolution approaches can enable us to make progress even without a full understanding of the cell, and can also lead to the discovery of new knowledge. This thesis is focused on addressing the technological bottlenecks in the directed evolution cycle, specifically de novo DNA assembly to generate strain libraries and small molecule product screens and selections. In Chapter 1, we begin by examining the origins of the field of metabolic engineering. We review the classic “design–build–test–analyze” (DBTA) metabolic engineering cycle and the different strategies that have been employed to engineer cell metabolism, namely constructive and inverse metabolic engineering. -
International Kv7 Channels Symposium 2019
ABSTRACT BOOK International Kv7 Channels Symposium 2019 INTERNATIONAL Kv7 CHANNELS SYMPOSIUM 12 - 14 September 2019 Naples · Italy www.kv7channels2019naples.org WELCOME Index Oral Abstracts . 21 Poster Abstracts . 71 INFORMATION PROGRAMME INDUSTRY ABSTRACTS 3 WELCOME INFORMATION 21 PROGRAMME Oral Abstracts Oral INDUSTRY ABSTRACTS KEYNOTE SPEAKER [O1] NEURONAL KV7 M-CHANNELS: PROPERTIES AND REGULATION David Brown1 1University College London, Neuroscience, Physiology & Pharmacology, London, United Kingdom I joined the band of future Kv7 afficionados 40 years ago, when we discovered the M-current in bullfrog sympathetic neurons (Brown & Adams, 1979: Soc. Neurosci. Abstr. 5:585; 1980:Nature, 283;673). This was seen as a voltage-de- pendent, subthreshold, non-inactivating potassium current that had a dramatic braking action on repetitive action potential discharges. It was dubbed “M-current” because it was inhibited by muscarine, acting on muscarinic ace- tylcholine receptors (mAChRs), thereby increasing action potential discharges. M-current is an imperfect descriptor because the current can also be inhibited by activating other Gq-type G protein-coupled receptors (GPCRs) and mus- carine itself only works if the cell has M1, M3 or M5 receptors, not M2 or M4 (Robbins et al., 1991: Eur J Neurosci. 3: 820). The molecular composition of the M-channel was revealed some two decades later by David McKinnon and his colleagues as a combination of theKCNQ2 and KCNQ3 gene products Kv7.2 and Kv7.3 (Wang et al., 1998: Science. 282: 1890), probably as a 2+2 heteromer (Hadley et al, 2003: J Neurosci. 23: 5012). Though gated by voltage, the channels require the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PIP2) to open (Zhanget al., 2003: Neuron.