Nutrients 2015, 7, 3401-3415; doi:10.3390/nu7053401 OPEN ACCESS nutrients ISSN 2072-6643 www.mdpi.com/journal/nutrients Article An Organic Khorasan Wheat-Based Replacement Diet Improves Risk Profile of Patients with Acute Coronary Syndrome: A Randomized Crossover Trial Anne Whittaker 1, Francesco Sofi 2,3,4,*, Maria Luisa Eliana Luisi 4, Elena Rafanelli 4, Claudia Fiorillo 5, Matteo Becatti 5, Rosanna Abbate 3, Alessandro Casini 2, Gian Franco Gensini 3 and Stefano Benedettelli 1 1 Department of Agrifood Production and Environmental Sciences, University of Florence, Piazzale delle Cascine 18, 50144 Florence, Italy; E-Mails:
[email protected] (A.W.);
[email protected] (S.B.) 2 Unit of Clinical Nutrition, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy; E-Mail:
[email protected] 3 Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy; E-Mails:
[email protected] (R.A.);
[email protected] (G.F.G.) 4 Don Carlo Gnocchi Foundation Florence, Via di Scandicci 269, 50143, Florence, Italy; E-Mails:
[email protected] (M.L.L.);
[email protected] (E.R.) 5 Department of Clinical and Experimental Biomedical Sciences, Interdipartimental Center for Research on Food and Nutrition, University of Florence, Sesto Fiorentino, Florence, 50019, Italy; E-Mails:
[email protected] (C.F.);
[email protected] (M.B.) * Author to whom correspondence should be addressed; E-Mail:
[email protected]; Tel.: +39-055-7949420; Fax: +39-055-7949418. Received: 20 November 2014 / Accepted: 21 April 2015 / Published: 11 May 2015 Abstract: Khorasan wheat is an ancient grain with previously reported health benefits in clinically healthy subjects.