Treatment for Fatigue in Multiple Sclerosis 27 No
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Health Technology Assessment 2000; Vol. 4: No. 27 Rapid review Treatments for fatigue in multiple sclerosis: a rapid and systematic review P Brañas R Jordan A Fry-Smith A Burls C Hyde Health Technology Assessment NHS R&D HTA Programme HTA Standing Group on Health Technology Current members Chair: Professor John Gabbay Dr Jeremy Metters Dr John Tripp Professor Kent Woods Director, Wessex Institute Deputy Chief Medical Officer, Senior Lecturer in Child Professor of Therapeutics, for Health Research Department of Health Health, Royal Devon and Exeter University of Leicester & Development Professor Maggie Pearson Healthcare NHS Trust Regional Director of R&D, Professor Sir John Professor Tom Walley Professor Martin Buxton NHS Executive North West Grimley Evans Director, Director & Professor of Professor of Clinical Geratology, Mr Hugh Ross Prescribing Research Group, Health Economics, Radcliffe Infirmary, Chief Executive, University of Liverpool Health Economics Oxford The United Bristol Research Group, Healthcare NHS Trust Dr Julie Woodin Brunel University Dr Tony Hope Professor Trevor Sheldon Clinical Reader in Medicine, Chief Executive, Professor Shah Ebrahim Joint Director, York Health Nuffield Department of Nottingham Health Authority Professor of Epidemiology Policy Group, University of York Clinical Medicine, of Ageing, University of Bristol University of Oxford Professor Mike Smith Professor Francis H Creed Faculty Dean of Research Professor of Professor Richard Lilford for Medicine, Dentistry, Psychological Medicine, Regional Director of R&D, Psychology & Health, Manchester Royal Infirmary NHS Executive West Midlands University of Leeds Past members Professor Sir Miles Irving* Professor John Farndon Professor Michael Maisey Professor Martin Roland Professor of Surgery, Professor of Surgery, Professor of Professor of General Practice, University of Manchester, University of Bristol Radiological Sciences, University of Manchester Hope Hospital, Salford Professor Charles Florey Guy’s, King’s & St Thomas’s School of Medicine & Dentistry, Professor Ian Russell Department of Epidemiology Dr Sheila Adam London Department of Health Sciences Department of Health & Public Health, Ninewells & Clinical Evaluation, Hospital & Medical School, Mrs Gloria Oates University of York Professor Angela Coulter University of Dundee Chief Executive, Director, King’s Fund, Professor Howard Oldham NHS Trust Dr Charles Swan London Glennester Consultant Gastroenterologist, North Staffordshire Professor of Social Science Dr George Poste Royal Infirmary Professor Anthony Culyer & Administration, London Chief Science & Technology Deputy Vice-Chancellor, School of Economics & Officer, SmithKline Beecham University of York Political Science Professor Michael Rawlins Dr Peter Doyle Mr John H James Wolfson Unit of Executive Director, Zeneca Ltd, Chief Executive, Clinical Pharmacology, ACOST Committee on Medical Kensington, Chelsea & University of Newcastle- Research & Health Westminster Health Authority upon-Tyne * Previous Chair Details of the membership of the HTA panels, the NCCHTA Advisory Group and the HTA Commissioning Board are given at the end of this report. 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Treatments for fatigue in multiple sclerosis: a rapid and systematic review P Brañas R Jordan A Fry-Smith A Burls C Hyde* West Midlands Development and Evaluation Service, The University of Birmingham, Birmingham, UK * Corresponding author Competing interests: none declared Published October 2000 This report should be referenced as follows: Brañas P,Jordan R, Fry-Smith A, Burls A, Hyde C.Treatments for fatigue in multiple sclerosis: a rapid and systematic review. Health Technol Assess 2000;4(27). Health Technology Assessment is indexed in Index Medicus/MEDLINE and Excerpta Medica/ EMBASE. Copies of the Executive Summaries are available from the NCCHTA website (see overleaf). NHS R&D HTA Programme he overall aim of the NHS R&D Health Technology Assessment (HTA) programme is to ensure T that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and work in the NHS. 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Fax: +44 (0) 23 8059 5639 Email: [email protected] http://www.ncchta.org Health Technology Assessment 2000; Vol. 4: No. 27 Contents List of abbreviations and glossary ............. i 4 Discussion ...................................................... 37 Importance of fatigue in MS ......................... 37 Executive summary .................................... iii Effects and effectiveness of treatment to alleviate fatigue in MS ..................................