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1680 1800 .. . I certify that the statsmsnts mad. by bl h me above .1S corv.ct and coets . ,#aj Ps Fsx 3526. Jay 1554 (See Mstrucj(#{243}’e on mono) AUTHOR INDEX

Abou-Donia, Mohamed B., 705 Chen, Chiadao, 421 Ferrari, P., 257, 635 Hwang, Bruce Y-H., 14 Abraham, Robert T., 732 Chen,S., 143 Ferry,JamesJ., 385 Adachi,T., 517 Cheng, Kuo-Chi, 222 Field, F. H., 784 Iga, Tatsuji, 131, 500 Ahluwahlia, Gurpreet S., 165 Cherry, Wendy F., 309, 314, 323, Finkle, Carolyn, 314 Albro, Phillip W., 742 698 Finnen, Michael J., 127 Allahyari, R., 35 Chism, John P., 596 Fiserova-Bergerova, V., 98 J#{228}hnchen, Eberhard, 760 Altomare, Emanuele, 20 Chiu, Shuet-Hing Lee, 464 Fontanella, L., 635 Jardine, Ian, 717 Alvin, John D., 732 Chou, Ming W., 403 Fong, Kei-Lai L., 14 Jarman, Michael, 5 11 Anderson, M. W., 527 Chun, Moon Woo, 784 Forte, Anthony J., 484 Jayaram, Hiremagalur N., 165 Anderson, Martin M., 179 Cleveland, Patricia A., 285 Foster, Allan B., S 1 1 Jenkins, E. E., 280 Arcamone, Federico, 506 Colburn, W. A., 143, 607 Foth, Heidi, 760 Jenner, Mark A., 106 Arison, Byron, 464 Conard,G.J.,414 Foureman, Gary L., 389 Jensen, J., 280 Arnold, Susan T., 165 Cone, Edward J., 577 Fouts, James R., 25 Johns,DavidG., 165 Assandri, A., 257, 635 Configliacchi, Emanuela, 506 Fox,JackJ., 784 Johnson,J.D.,414 Asscher, Y., 371 Conroy, Curtis W., 614 Fraser, I. M., 35 Johnson, Rolley E., 577 Awazu, Shoji, 253 Cook, C. Edgar, 186, 677 Friday,S., 631 Jollow, David J., 271 Axworthy, D. B., 565 Coomes, Marguerite Wilton, 25 Friedman, P. A., 550 Jones, C. E., 280 Coon, Minor J., 358 Fu, Peter P., 403 Jordan, Sandra, 742 Baba, Shigeo, 767, 795 Cooney, David A., 165 Fung, Ho-Leung, 353 Babiak, Lesia M., 698 Corbett, Jean T., 742 Kahl, Georg F., 760 Bachur, Nicholas R., 209, 365 Cornish,H.H., 154 Garrettson, L. K., 792 Kahl, Regine, 760 Bagley, Jerome R., 478 Cotler, S., 143 Gaudreault, P., 550 Kahn, Jack R., 63 Bai, Stephen A., 749 Cousins, Michael J., 106 Gee,S.J., 174 K#{225}llay,Zolt#{227}n, 641 Bailey, John R., 148 Cox, Richard H., 389 George, John W., 304 Kaminsky, Laurance S., 470 Baillie, T. A., 565 Coyle, Dennis E., 625 Gillette, James R., 193, 291 Kapetanovic, I. M., 560 Banitt,E.H.,414 Crooks, P. A., 755 Godin, C. S., 755 Karl, P. I., 550 Bankert, C. S., 280 Cundy, K. C., 755 Gomez, Hector J., 242 Kato, Akira, 492 Barone, D., 257 Curphey, Thomas J., 427 Goodman, Robert P., 782 Kawiecki, R. W., 98 Bartels, Michael J., 345, 382 Gorodetzky, Charles W., 577 Keith, Richard A., 717 Beaune, Philippe, 470 Dahl, Raymond R., 536 Grage,G.M.,553 Keller, B., 120 Beierschmitt, William P., 266 Dallas, J. L., 68 Grasela, Dennis M., 204 Kerremans, Adrian, 717 Bekersky, Ihor, 607 Dawson, Christopher A., 536 Green, C. E., 174 Kettner, Milan, 641 Bencsath, Aladar, 784 Dawson, Janet R., 323 Griffeth, Landis K., 582, 588 King, Shang-Ying P., 353 Bend, John R., 389 deBethizy, J. Don, 45 Griffith, Donald P., 438 Klempner, Mark S., 790 Ben-Zvi, Zvi, 389 DeBree,H.,82 Griggs, Leslie J., 5 1 1 Knaeps, F., 772 Bethel, Adrianna M. M., 782 Dedrick, R. L., 527 Guengerich, F. Peter, 470 Knapp, Joseph E., 732 Bezek, Stefan, 641 Deesen, Patricia E., 9 Gurka, David P., 421 Kolmstetter, Christine, 460 Bhargava, V. 0., 792 De Lange, N., 82 Kong, Philomena, 314 Demaster, E. G., 337 Kupferberg, H. Birkett, D. J., 798 Haddon, William F., 68 J., 560 Bjorge, S. M., 565 Denson, Donald D., 625 Hall, Pauline de la M., 106 Kuroda, Nobuo, 767 DeSouza, John J. V., 165 Bochenek,W.J.,631 Hanano, Manabu, 131, 253, 500 Kwon, C. H., 337 DeWit,R.H., 154 Bock, Karl Walter, 93 Harper, Gregory R., 165 Borondy, P. E., 444 Dickinson, Ronald G., 247 Hashida, Mitsuru, 492 Lacefield, W. B., 691 Borst, A. J. M., 82 Dobrinska, Michael R., 242 Hassall, Kenneth A., 127 La Du, Bert N., 57 Dodion, Pierre, 209, 365 Bourke, C. E., 798 Hendrickx,J., 772 Lambert, Carolyn M., 782 Bourne, G. R., 652 Dollery, Cohn T., 242 Hernandez, Oscar, 389 Larrey, Dominique, 470 Boyd, M. R., 787 Dunbar, Deborah A., 470 Heykants, J., 772 Lau, Serrine S., 193, 291, 432 Duncan, Carol A. H., 242 Brabec,M.J., 154 Highet, Robert J., 432 Lauwers, W., 772 Duriiov#{225},Maria, 641 Brine, Dolores R., 186, 677 Hilbert, James, 452 Lefers, Roger C., 421 Brock, William J., 712 Dutka, V. N., 652 Hill, Donald L., 63 Leibman, Kenneth C., 4, 460, 661 Brough, Eda Lee, 421 Hinson,JackA., 179 Leidy, H. Lorraine, 242 Buchholz, J., 35 Eadie, Mervyn J., 247 Ho, P. C., 787 Lasher, Gary A., 266 Buchwald, William F., 577 Eckerson, Harry W., 57 Hoag, M. K. P., 371 Lesne, M., 235 Egorin, Merrill J., 209, 365 Hooper, Wayne D., 247 Leung, Chui-Sheung, 5 1 1 Cassidy, M. Kevin, 619 Engisch, Kathrin L., 365 Horie, Masanobu, 767, 795 Levy, Ren#{233}H., 139 Cassinelli, Giuseppe, 506 Erichieb, Miloi, 641 Horning, E. C., 297 Leyland-Jones, Brian, 9 Castagnoli,Jr., N., 371 Evans, Frederick E., 403 Horning, M. G., 297 Lieber, Charles S., 20 Cerniglia, Carl E., 330 Houston, J. Brian, 619 Lilienblum, Werner, 93 Chae, Kun, 742 Faltus, Frantis#{233}k, 641 Howe, Ian, 511 Lin, C., 51 Chait, Brian, 784 Fayz, Shim, 314, 323, 698 Huang,J.C., 314 Lin, Jiunn Huei, 253 Chang, Barbara K., 365 Feinberg, Aaron, 784 Huckle, Keith R., 264 Lindstrom, T. D., 72, 683, 691 Chang, S. F., 414 Feldman, Stuart, 438 Hurkmans, R., 772 Lipe, George W., 148 Chang, Shih-Ling, 139 Ferrari, Laura, 506 Hutson, David H., 264, 523 Litterst, Charles L., 165 801 802 AUTHOR INDEX

Logan, Christopher J., 523 Olman, Eve A., 365 Sawada, Yasufumi, 131, 500 Trnovec, Tom#{227}i,641 Longnecker, Daniel S., 427 Ortiz, Elsa, 460 Schaeffer, Barbara K., 427 Tuan,G.,257,635 Loosli,H.R., 120 Schenkman, John B., 222 Tuey, D., 527 Lu, Anthony Y. H., 464 Pacciarini, Adele, 506 Schentag, Jerome J., 217 Turner, Max J., Jr., 596 Lutz, R. J., 527 Pang, K. Sandy, 309, 3 14, 323, 698 Scherpenisse, P. M., 82 Turner, Patricia A., 625 Paoletti, Claude, 1 1 1 Schnellmann, Rick G., 470 Tyson, C. A., 174 Macasieb, T., 143 Pape, Courtney W., 478 Schreier, E., 120 Maftouk, Mohamed, 1 1 1 Patel, J. M., 460 Schroeder, Joanna, 742 Ueda, Clarence T., 285 Malbica, J. 0., 396 Pathre, S. V., 4 14 Schuessler, D., 51 Uetrecht, Jack P., 77 Malspeis, Louis, I65 Peggins,JamesO., 379 Schwam, Harvey, 614 Ulm, Edgar H., 309 Segall, H. J., 68 Manson, Donald, 5 1 1 Pellegrin, P. L., 235 Maren, Thomas H., 614 Penco, Sergio, 506 Sestokas, Elena, 464 Vendemiale, Gianluigi, 20 Marten, T. R., 652 Perazzi, A., 257, 635 Sezaki, Hitoshi, 492 Vickers, Stanley, 242 Martinelli, E., 635 Perez-Reyes, Mario, 677 Shank, Ronald G., 217 Vidal,PedroM.,784 Sheets, Joel J., 603 Mason, J. Ian, 603 Petersen, Dennis R., 725 Vincek, William C., 242 Sheng, L-S., 297 Matthews, H. B., 527 Pfadenhauer, E. H., 199, 280 Vincent, W. R., 82 Maurer, G., 120 Philips, Frederick S., 784 Shipley, Lisa A., 379 von Bahr, Christer, 93 Mays, Joann B., 179 Philpot, Richard, 742 Shirota, F. N., 337 Vore, Mary, 712 Shuker, B., 652 McCloskey, James A., 280 Plummer, John L., 106 Sipes, I. Glenn, 470, 527 McDonald, Jerome J., 330 Pohl, Lance R., 193, 304 Wagner,JohnG., 385 Sladek, N. E., 553 McQuinn,R.L.,4l4 PohI, Roberta J., 25 Wall, Monroe E., 677 Slattery, John T., 484 Mehendale, Harihara M., 376 Popick, Andrea C., 607 Walle, Thomas, 749 Slikker, Jr., William, 148 Melgar, M. D., 396 Post, L. C., 82 Wang, C. Y., 672 Smith, Jack L., 464 Meuldermans, W., 772 Powers, J. F., 553 Wang, Philip P., 470 Some, W. H., 792 Meunier, Bernard, I I I Pramanik, Birendra, 5 1, 452 Wang, Richard I. H., 536 Sparks, Rebecca W., 25 Michniewicz, B. M., 444 Puar,M.S.,5l Wanwimolruk, Sompon, 106 Spearman, Marshall E., 661 Miles, G. 5., 652 Putcha, Lakshmi, 438 Watanabe, Kyoichi A., 784 Staubus, Alfred E., 165 Millburn, Peter, 264 Weiner, Myron, 000, 379 Streeter, A. J., 565 Miller,G. E., 154 Quarforth,G.J.,414 Weinshilboum, Richard M., 717 Streeter, David G., 199 Miller, Marion G., 271 Weissman, J., 371 Strother, A., 35 Minchin, R. F., 787 Wells, Mary Jane, 63 Radulovic, L. L., 154 Styrt, Barbara, 790 Miners,J.O., 798 Whitaker, G. W., 72, 683, 691 Ramjit, Ham G., 242 Sugita,Osamu, 131 Minnigh, M. Beth, 732 Wiebkin, Philip, 427 Rankine, H. D., 652 Sugiyama, Yuichi, 131, 253, 500 Mitchum, Ronald K., 179 Wilson, Beverly K., 161 Rao, Ren#{233}eC., 1 1 1 Sweetman, Brian J., 77 Molli#{232}re,Michael, 760 Wilson, John M., 484 Rauckman, Elmer J., 582, 588 Swysen, E., 772 Monks, Terrence J., 193, 291, 432 Wilson, Yvonne A., 165 Regan, Peter D., 523 Symchowicz, Samson, 5 1, 452 Monsarrat, Bernard, I I I Woestenborghs, R., 772 Rickert, Douglas E., 45, 596 Sziszak, Thomas J., 148 Morgan, Edward T., 358 Wong, Lan K., 732 Riggs, Jr., Charles E., 209 Szpunar, Gregory J., 385 Mon. Yukio, 767, 795 Ripamonti, A., 257, 635 Wood, Alexander W., 543 Morton, K. C., 672 Ritschel, Wolfgang A., 625 Takakura, Yoshinobu, 492 Woosley, Raymond L., 77 Mulder, Gerard J.,323 Rivola, Giovanni, 506 Wright, Jackson T., Jr., 782 Myers,JaneA., 625 Tallent, C. Ray, 186 Rocci, Jr., Mario L., 204 Tamburini, July M., 209 Rodgers, J. B., 631 Tanaka,A., 517 Yagen, Boris, 389 Nagasawa,H.T., 337 Roerig, David L., 536 Tarka, S. M., 154 Yamaha,T., 517 Navarov#{227},Jana, 641 Rosen, Gerald M., 582, 588 Tarzia,G., 635 Yang, Shen K., 403 Nelson, Sidney D., I 39, 484, 565 Rowlands, Martin G., 5 1 1 Taub, Rae, 464 Yokoya, Fusayuki, 767 Nelson, Wendel L., 345, 382 Ruenitz, Peter C., 478 Terrell,Julia A., 309 Yoshikawa, Takayoshi, 500 Nomeir, Amin A., 705 Ruijten, H. M., 82 Thompson, Gary A., 625 Yousefnejad, David, 577 Norman, Richard L., 543 Ryan, Adrian J., 389 Thompson, John A., 161, 725 Norris, Kenneth J., 725 Tilton, B. E., 35 Zampaglione, Nicola, 452 Sakai, Yoshiyuki, 767, 795 Tom#{234}ikov#{227},Olga, 641 Zemaitis, Michael A., 732 Oates, John A., 77 Sato,M.,5l7 Town, Christopher, 4 Zerilli, L. F., 257 Ober,R.E.,4l4 Sato, Paul H., I Toyoshi, Kazumi, 767, 795 Ziemniak, John A., 217 Ohmiya, Yoshio, 376 Satoh, Hiroko, 304 Trevor,A.J., 371 Zuleski, F. R., 396 SUBJECT INDEX

Acetamide, disposition, 438 4’-Epidoxorubicin, 9 p-Acetamidobenzoic acid, 199 metabolism, 506 Acetaminophen, 20, 565 Epoxides, glutathione conjugation during aging, 661 catechol metabolites, 484 erythro-9-(2-Hydroxy-3-nonyl)hypoxanthine, 280 hepatotoxicity, 323 Estradiol, metabolism, 222 sulfation, 323 17/3-Estradiol, treatment in pregnancy, 712 Acetohydroxamic acid, disposition, 438 Estrogen metabolism, 148 N-Acetylcyanamide, 337 Ethanol, 20 N-Acetylcysteine, 717 Ethoxybenzamide, product inhibition, 253 i-a-Acetylmethadol, 266 7-Ethoxycoumarin, O-deethylation, 25 Acrolein, 460 Ethylmorphine demethylase, induction, 266 i-Adrenoreceptor agonist, 652 Ethynylated steroids, 148 Allopurinol, 672 Allylic oxidation, 186 Flecainide acetate, metabolism, 414 Alprenolol, glucuronic acid conjugates, 749 l-(2-Fluoro-2-deoxy-/3-o-arabinofuranosyl)-5-methyluracil, 784 Aminoglutethimide, 5 1 1 Fluvoxamine, 82 Aniline hydroxylase, induction, 266 Furazolidone, reductive metabolism, 732 Antipyrine, clearance, 139 , 365 Gentamicin, aerosol administration, 641 Arylamine, oxidation, 77 Gentian violet, biotransformation, 330 Arylhydroxylamine, 77 Gitoxin, hepatic clearance, 235 Ascorbate, 323 Glucaron, 672 Avermectin, H2B1a and H2B1,, 464 1-($-n-Glucopyranosyl)phenobarbital, 792 Glutathione, 614 Benzo(a)pyrene, covalent binding, 760 Glutathione S-transferases, aging effects, 661 Bromobenzene, 193, 291 o-Bromophenol, mechanism of formation, 193 Halothane p-Bromophenol, metabolites, 432 biotransformation, 106 Bupivacaine, 625 capacity-limited metabolism, 98 Buprenorphine, 577 flow-limited metabolism, 98 metabolites, 98 Captopril, 717 4-Hydroperoxycyclophosphamide, 553 Carbamazepine, 204, 560 3’-Hydroxyacetanilide, 565 Carbamazepine-cimetidine interaction, 204 2’-Hydroxyacetanilide, 565 Cerebrospinal fluid,217 4-Hydroxycyclophosphamide, 553 Chloroform, inducement of nephrotoxicity, 304 8-Hydroxymethylbenz[a]anthracene, metabolites, 403 Cholinesterase, human serum, 57 o-Hydroxyphenylethanol, 543 Cimetidine, 106, 204, 217, 625 4-Hydroxytamoxifen, 478 acetylation, 782 7-Con-O-methylnogarol, 365 ICI, 1 18, 587, 652 Cotinine, 725 lloprost, 645 Coumarin, 543 Iminium ion, 371 Cyanamide, 337 Imipramine, 376 , 553 Indecainide Cyclosporin, disposition, 120 metabolism, 691 Cysteine, 614 pharmacokinetics, 683 Cytochrome b5, manganese-substituted, 358 Inosiplex, 199 Cytochrome P-450 Isotretinoin, pharmacokinetics, 143 human liver, 470 Isoxicam, metabolism, 444 inactivation, 371 Isozyme composition, cytochrome P-450, 470 oxidation after trauma, 582, 588

Keratinocytes, 25 Dapsone, acetylation, 782 Ketanserin, metabolism and excretion, 772 Daunomycin, leukocyte uptake, 790 cij3-Ketoalkene reduction, 72 Dehydropyrrolizine metabolites, 68 Ketoconazole, 603 Diazepam, pulmonary uptake, 536 2,6-Dichloro-4-nitrophenol, 323 7,8-Dichloro-l,2,3,4-tetrahydroquinoline, aromatization, 14 Marcellomycin Diheptyl phthalate, metabolism, 517 disposition, 209 Dimethylaminoisopropanol, 199 metabolism, 209 Menogarol, 365 Meperidine, N-demethylation, 698 Enalapril, 309 Methadone, pulmonary uptake, 536 Enalaprilat, 309 Methemoglobin, 35 803 804 SUBJECT INDEX

3-Methylcholanthrene, 403 Propranolol, glucuronic acid conjugates, 749 Methyldopa Propranolol, glucuronidation, I 61 ester progenitor, 242 Prostacyclin, 645 metabolism, 242 Putrescine, 550 Methylsulfonium, 297 , 492 Quazepam, metabolism and disposition, 452 Mono-2-ethylhexyl phthalate, metabolism, 742 Mononitrotoluenes, metabolism, 596 Ranitidine, 106 NADPH-cytochrome c reductase, inactivation by acrolein, 460 , disposition, 63 Nafimidone, 560 Rosaramicin, metabolism, 51 6fi-Naltrexol, 677 Naltrexone, disposition, 677 Salicylate, 285 Neonatal imprinting, 127 Salicylate, tissue distribution, 500 Nicotine, 725 Smoke inhalation, 376 N-oxide, 725 Styrene oxide, 297 stereospecificity, 755 Sulfamethoxazole, 131 Nitrate, pentaerythritol, 353 Sulfamoyl group displacement, 614 Nitrates, organic, 353 Sulfaphenazole, 131 4-Nitroaniline, microsomal metabolism, 179 Sulfisoxazole, 607 Nitrofurans, 732 Suprofen, dog metabolism, 795 metabolism, 672 Suprofen, rat metabolism, 767 Nitrofurantoin, in isolated perfused rat lung, 787 Swine, miniature, drug metabolism, 379 N-Methyl-9-hydroxy-9-hydroxyellipticinium, I I I Tamoxifen, microsomal metabolism, 478 Oral contraceptive agents, 148 Tamoxifen epoxide, 478 Oxazaphosphorines, 553 Theobromine, 154 Thiol methyltransferase, 717 Paraoxinase, 57 7or-Thio-spironolactone, 717 Paraoxon, 57 Tiazofurin, disposition and metabolism, 165 Paraquat, 550 Tolbutamide, metabolism in hepatocytes, 174 D-Penicillamine, 798 Tolbutamide-sulfonamide interactions, 131 Phencyclidine, metabolism, 371 Tracazolate, metabolism, 396 Phenol, conjugation, 619 Trifluoroacetic acid, distribution, 98 Phenothiazine, 672 Tri-o-cresyl phosphate, disposition, 705 3-Phenoxybenzoic acid, metabolism, 264 l-Phenylcyclohexane, metabolism in vitro, 186 UDP-glucuronyltransferase, human, 93 Phenytoin, 560 UDP-glucuronyltransferase, induction by phenytoin and pentobarbital, Phenytoin, pharmacokinetics, 285 93 Poloxalene 2930, 631 Polychlorinated biphenyls, 527 Vaiproate glucuronide, 247 Polychlorinated ethanes, 4 Valproic acid, 247 Premazepam, metabolism, 257 Primaquine, metabolism, 35 Procainamide, metabolism, 77 Warfarin, metabolism, 470 Procainamide, N-acetylaticn, 314 Progesterone, metabolism, 222 Zetidoline, 635 Propranolol, aromatic hydroxylation, 382 Zoxazolamine, 582, 588