Acrylamide Mammography Cohort, the Netherlands Study on Diet and Can- Cer, a Cohort of Swedish Men, the U.S
Report on Carcinogens, Fourteenth Edition For Table of Contents, see home page: http://ntp.niehs.nih.gov/go/roc Acrylamide Mammography Cohort, the Netherlands Study on Diet and Can- cer, a cohort of Swedish men, the U.S. Nurses’ Health Study, and the CAS No. 79-06-1 Danish Diet, Cancer, and Health Study. In addition, several case- control studies (most of which used food-frequency questionnaires) Reasonably anticipated to be a human carcinogen assessed cancer and dietary exposure of Swedish, French, and U.S. First listed in the Sixth Annual Report on Carcinogens (1991) populations to acrylamide. The tissue site studied most frequently Also known as 2-propenamide was the breast. These studies found no overall association between breast cancer and dietary exposure to acrylamide; however, some, H C NH2 but not all, studies reported an association between acrylamide ex- H2C C posure and a specific type of breast cancer (sex-hormone-receptor- O positive cancer in post-menopausal women). The Danish study used Carcinogenicity acrylamide-hemoglobin adducts to assess exposure; however, these adducts are not source-specific, but reflect both dietary exposure Acrylamide is reasonably anticipated to be a human carcinogen based and exposure from other sources, such as smoking. Two of three pro- on sufficient evidence of carcinogenicity from studies in experimen- spective cohort studies reported increased risks of endometrial and tal animals. ovarian cancer, but a case-control study found no increased risk of ovarian cancer. Most of the studies evaluating prostate and colorectal Cancer Studies in Experimental Animals cancer did not find increased risks associated with dietary exposure Acrylamide caused tumors in two rodent species, at several different to acrylamide.
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