467 Opening Ceremony/ Keynote Lecture/ Keynote Lecture Plenary Lecture

Keynote Lecture p.523

Thursday, September 17, 16:00～17:00 (JST) Live Streaming

KL Molecular targeting of Treg cells for controlling immune responses Chair: Motohiro Ebisawa Clinical Research Center for and Rheumatology, National Hospital Organization Sagamihara National Hospital, Speaker: Shimon Sakaguchi Department of Experimental Immunology, WPI Immunology Frontier Research Center, , Japan

Opening Ceremony

Opening Ceremony p.524

Thursday, September 17, 17:00～18:30 (JST) Live Streaming

A Special Tribute to Dr. Kimishige Ishizaka and Dr. Teruko Ishizaka Chairs: Motohiro Ebisawa Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan Yuji Tohda Department of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine, Japan Continuing impact of the discovery of IgE by the Ishizakas Speaker: Hirohisa Saito National Research Institute for Child Health & Development, Japan Dr. Kimishige Ishizaka's recorded presentation “Identification of ” Speaker: Kimishige Ishizaka (1925-2018) La Jolla Institute for Allergy and Immunology, USA Special Message from Prof. Terumasa Miyamoto Speaker: Terumasa Miyamoto The University of , Japan

Plenary Lecture

Plenary Lecture 1 p.526

Immunotherapy PL-1-1 Sublingual immunotherapy and anti-IgE therapy for Japanese cedar pollinosis in Japan Speaker: Kimihiro Okubo Department of Otolaryngology, Nippon Medical School, Japan PL-1-2 Allergen Immunotherapy (AIT) in Speaker: Ignacio J Ansotegui Department of Allergy & Immunology, Hospital Quironsalud Bizkaia, Spain PL-1-3 Feld 1-specific IgG4 antibodies: biologicals for cat allergy Speaker: Mohamed Shamji Imperial College London National Heart and Lung Institute; Asthma UK Centre in Allergic Mechanisms of Asthma, UK

Plenary Lecture 2 p.527

Skin Allergy PL-2-1 Insights into chronic urticaria for diagnosis and management Speaker: Michihiro Hide Department of Dermatology, Hiroshima University, Japan PL-2-2 Hereditary (HAE) Speaker: Marcus Maurer Department of Dermatology & Allergy, Charité-Universitätsmedizin Berlin, Germany PL-2-3 Atopic eczema - is the epithelium the problem? Speaker: Lisa A Beck Dermatology, Medicine and Pathology, University of Rochester Medical Center, USA

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Plenary Lecture 3 p.528

Food Allergy PL-3-1 Management of in Japan Speaker: Motohiro Ebisawa Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan PL-3-2 Food allergy: current and future treatment Speaker: Hugh A Sampson Department of Pediatrics, Icahn School of Medicine at Mount Sinai, USA Plenary Lecture PL-3-3 Adjuvants and OIT Speaker: Mimi Tang Department of Allergy Immunology, Murdoch Children's Research Institute (MCRI), Australia

Plenary Lecture 4 p.529

Basic Science PL-4-1 Regulation of allergic responses to food by intestinal bacteria Speaker: Cathryn Rose Nagler Department of Pathology, Biological Sciences Division and Pritzker School of Molecular Engineering, The University of Chicago, USA PL-4-2 Group 2 innate lymphoid cells regulate susceptibility to allergic disorders Speaker: Kazuyo Moro Laboratory for Innate Immune Systems, Graduate School of Medicine, Osaka University School of Medicine; Laboratory for Innate Immune Systems, RIKEN-IMS, Japan PL-4-3 The epithelial barrier hypothesis for the development of allergic and autoimmune diseases Speaker: Cezmi A Akdis Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Christine Kühne- Center for Allergy Research and Education (CK-CARE), Switzerland

Plenary Lecture 5 p.530

Environmental Factors PL-5-1 The impact of climate change on pollen allergy and forecast system for allergenic pollen in future Speaker: Jae-Won Oh Department of Pediatrics, College of Medicine, Division of Allergy and Respiratory Diseases, Hanyang University, Guri Hospital, Republic of Korea PL-5-2 The allergenic activity of mites and fungi IgE-binding components Speaker: Luis Caraballo Institute for Immunological Research, University of Cartagena, Colombia PL-5-3 Environmental factors on airway and allergic disease: air pollution and global warming Speaker: David Blaine Peden Department of Pediatrics and Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, USA

Plenary Lecture 6 p.531

Eosinophils and Related Diseases PL-6-1 Mechanisms of eosinophilic inflammation Speaker: Makoto Nagata Department of Respiratory Medicine/Allergy Center, Saitama Medical University, Japan PL-6-2 Eosinophils and eosinophil-related diseases Speaker: Robert Schleimer Allergy and Immunology, Northwestern University Feinberg School of Medicine, USA PL-6-3 Eosinophilic gastrointestinal diseases-clinical manifestations and therapeutic options Speaker: Glenn Furuta Department of Pediatrics, University of Colorado School of Medicine/Children's Hospital Colorado, USA

Plenary Lecture 7 p.532

Severe Asthma PL-7-1 Mechanism of severe asthma (Tentative) Speaker: Giorgio Walter Canonica Internal Medicine, Humanitas University & Research Hospital, Italy PL-7-2 Biomarkers of severe asthma (SA): lessons from longitudinal cohorts Speaker: Hae-Sim Park Department of Allergy & Clinical Immunology, Ajou University Medical Center, Republic of Korea PL-7-3 Treatment of severe asthma Speaker: Sally E Wenzel Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, USA

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Plenary Lecture 8 p.533

Prevention PL-8-1 Basic concept about primary prevention of allergic diseases Speaker: Hirohisa Saito National Research Institute for Child Health & Development, Japan PL-8-2 Allergy prevention Speaker: Harald Renz Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg; University Hospital Giessen and Marburg GmbH, Germany PL-8-3 Prevention of and food allergy (Tentative) Speaker: George Du Toit Paediatric Allergy, Kings College London, School of Life Course Sciences and School of Immunology & Microbial Sciences, UK

Symposium Plenary Lecture/ Symposium Symposium 1 p.534

Severe Asthma SY-1(I-1)-1 How close are we to precision medicine for severe/difficult to treat asthma? Speaker: Hisako Matsumoto Department of Respiratory Medicine, Graduate School of Medicine Kyoto University, Japan SY-1(I-1)-2 Phenotypes of severe asthma Speaker: Sang Heon Cho Department of Internal Medicine, Seoul National University College of Medicine, Republic of Korea SY-1(I-1)-3 Biology meets biologics: severe asthma treatment in 2020 Speaker: Sally E Wenzel Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, USA

Symposium 2 p.535

Prevention of Allergy SY-2(P-1)-1 Environmental exposures and life-course trajectories of allergic diseases Speaker: Adnan Custovic National Heart and Lung Institute, Imperial College London, UK SY-2(P-1)-2 Allergy prevention by combatting skin sensitization Speaker: Yukihiro Ohya Allergy Center, National Center for Child Health and Development, Japan SY-2(P-1)-3 Allergy prevention by microbial manipulation: are we ready? Speaker: Ting Fan Leung Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong

Symposium 3 p.536

Eosinophilic Gastrointestinal Disease (EGID) SY-3(M-1)-1 Pathogenesis of (EoE) -how does the esophagus respond to allergens? Speaker: Glenn Furuta Department of Pediatrics, University of Colorado School of Medicine/Children's Hospital Colorado, USA SY-3(M-1)-2 Eosinophilic esophagitis what the allergist needs to know Speaker: Luc Biedermann Division of Gastroenterology & Hepatology, University Hospital Zurich, Switzerland SY-3(M-1)-3 Eosinophilic gastroenteritis in Japan Speaker: Yoshikazu Kinoshita Steel Memorial Hirohata Hospital, Japan

Symposium 4 p.537

Chronic Rhinosinusitis and Upper Airway SY-4(E-1)-1 Chronic Rhinosinusitis (CRS) and the upper airway Speaker: Robert Schleimer Allergy and Immunology, Northwestern University Feinberg School of Medicine, USA SY-4(E-1)-2 What should a surgeon know about the phenotypes of chronic rhinosinusitis with nasal polyps Speaker: Luo Zhang Department of Otolaryngology Head and Neck Surgery, Capital Medical University, China SY-4(E-1)-3 Eosinophilic chronic rhinosinusitis Speaker: Shigeharu Fujieda Division of Otorhinolaryngology - Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Japan

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Symposium 5 p.538

Contact Dermatitis SY-5(D-1)-1 The mechanical understanding of allergic develops the in vitro method to detect sensitising chemicals Speaker: Setsuya Aiba Departmemt of Dermatology, Tohoku University Graduate School of Medicine, Japan SY-5(D-1)-2 Clinical variation of hair dye allergy Speaker: Jun Young Lee Department of Dermatology, The Catholic University of Korea, Seoul St Mary's Hospital, Republic of Korea SY-5(D-1)-3 Status of contact dermatitis and patch testing initiatives in Japan Speaker: Akiko Yagami Department of Allergology, Fujita Health University School of Medicine, Japan

Symposium 6 p.539

Roles of ILCs SY-6(B-1)-1 The role of group 2 innate lymphoid cells in lung fibrosis Speaker: Kazuyo Moro Laboratory for Innate Immune Systems, Graduate School of Medicine, Osaka University School of Medicine; Laboratory for Innate Immune Systems, RIKEN-IMS, Japan SY-6(B-1)-2 Role of group 2 innate lymphoid cells in the development of allergic diseases Speaker: Hideaki Morita Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Japan SY-6(B-1)-3 Pathophysiology of severe asthma Speaker: Koichi Fukunaga Pulmonary Division, Department of Medicine, Keio University School of Medicine, Japan

Symposium 7 p.540 Symposium

Adult Food Allergy SY-7(I-2)-1 Adult food allergy: an increasingly recognized challenge Speaker: Barbara Ballmer-Weber Clinic of Dermatology and Allergology, Kantonsspital St Gallen, Switzerland SY-7(I-2)-2 Occupational food allergy Speaker: Yuma Fukutomi National Hospital Organization Sagamihara National Hospital, Japan SY-7(I-2)-3 Progress in alpha gal allergy Speaker: Michael Levin University of Cape Town, South Africa

Symposium 8 p.541

Mast Cells, Basophils and Eosinophils SY-8(B-2)-1 Human mast cell interaction with inflammatory cells in allergic diseases Speaker: Yoshimichi Okayama Center for Allergy/Center for Education, Nihon University School of Medicine, Japan SY-8(B-2)-2 Basophil activation in oral immunotherapy for Speaker: Mindy Tsai Department of Pathology/Sean N Parker Center for Allergy & Asthma Research, Stanford University School of Medicine, USA SY-8(B-2)-3 Eosinophil siglecs: biology and therapeutic advances Speaker: Bruce S Bochner Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, USA

Symposium 9 p.542

Airway Mycosis in Allergic Airway Disease SY-9(I-3)-1 Allergic bronchopulmonary aspergillosis Speaker: Ritesh Agarwal Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, India SY-9(I-3)-2 The presence of basidiomycetous fungi in the airway- how to take this troublesome pathogen Speaker: Katsuhiko Kamei Chiba University, Japan SY-9(I-3)-3 Allergic bronchopulmonary aspergillosis/mycosis in Japan Speaker: Koichiro Asano Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan

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Symposium 10 p.543

Pediatric Asthma SY-10(P-2)-1 New GINA guidelines Speaker: Gary Wong Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SY-10(P-2)-2 JPGL 2020 Speaker: Shigemi Yoshihara Department of Pediatrics, Dokkyo Medical University, Japan SY-10(P-2)-3 Do we need new guidelines in pediatric asthma? Speaker: Mário Morais-Almeida Immunoallergy Center, Allergy Center Hospital CUF-Descobertas, Portugal

Symposium 11 p.544

Atopic Dermatitis SY-11(D-2)-1 Current problems in the management of atopic dermatitis Speaker: Norito Katoh Department of Dermatology, Kyoto Prefectural University of Medicine, Japan SY-11(D-2)-2 Biomarkers for severity and endotyping in atopic dermatitis Speaker: Edward F Knol Center Translational Immunology, Department of Immunology and Department of Dermatology/ Allergology, University Medical Center Utrecht, The Netherlands SY-11(D-2)-3 What's new in the treatment and prevention of atopic dermatitis? Speaker: Lisa A Beck Dermatology, Medicine and Pathology, University of Rochester Medical Center, USA

Symposium 12 p.545

Fruit Allergy Symposium SY-12(M-2)-1 Basic mechanism on PFAS and the usage of component-resolved diagnostics in fruit allergy Speaker: Yasuto Kondo Department of Pediatrics, Fujita Health University School of Medicine General Allergy Center, Japan SY-12(M-2)-2 Gibberellin-regulated protein allergy Speaker: Naoko Inomata Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Japan SY-12(M-2)-3 Immunotherapy in fruit allergy Speaker: Ignacio J Ansotegui Department of Allergy & Immunology, Hospital Quironsalud Bizkaia, Spain

Symposium 13 p.546

Pollinosis SY-13(E-2)-1 Pollinosis - recent epidemiological data Speaker: Philip Rouadi Department of Otolaryngology and Allergy, Lebanese Allergy Immunology-World Allergy Organization, Lebanon SY-13(E-2)-2 Climate change effect on pollen allergy and on asthma induced by pollens Speaker: Gennaro D'Amato School of Specialization in Respiratory Diseases, University of Naples Federico II, Italy SY-13(E-2)-3 Unique feature of Japanese cedar pollinosis Speaker: Daiju Sakurai Department of Otorhinolaryngology, Head and Neck Surgery, University of Yamanashi, Japan

Symposium 14 p.547

Netting ANCA-Associated Vasculitis―Advances in Disease Mechanisms and Targeted Therapies SY-14(I-4)-1 Eosinophilic granulomatosis with polyangiitis: disease phenotype and management Speaker: Ulrich Specks Division of Pulmonary & Critical Care Medicine, Mayo Clinic, USA SY-14(I-4)-2 ANCA associated vasculitis: a personal story of 35 years of research Speaker: Jan Willem Cohen Tervaert Department of Medicine, Division of Rheumatology, University of Alberta, Canada; Department of Medicine-Immunology, Maastricht University, The Netherlands SY-14(I-4)-3 Updates on the pathogenesis of ANCA-associated vasculitis Speaker: Akihiro Ishizu Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Japan

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Symposium 15 p.548

Barrier (Lung, Skin, GI) SY-15(B-3)-1 Epithelial barrier in bronchial epithelium Speaker: Cezmi A Akdis Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Christine Kühne- Center for Allergy Research and Education (CK-CARE), Switzerland SY-15(B-3)-2 Homeostatic mechanisms of skin barrier and their disruption in skin inflammation Speaker: Masayuki Amagai Department of Dermatology, Keio University School of Medicine; Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Japan SY-15(B-3)-3 The mucosal barrier in GI lessons learned for the clinician from basic science Speaker: Luc Biedermann Division of Gastroenterology & Hepatology, University Hospital Zurich, Switzerland

Symposium 16 p.549

Allergic Diseases and Immunodeficiency SY-16(P-3)-1 Overview of inborn errors of immunity: from a point of view of allergists Speaker: Yusei Ohshima Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Japan SY-16(P-3)-2 Early diagnosis in primary immunodeficiencies: red flags and alert signs Speaker: José Antonio Ortega-Martell Department of Immunology, Autonomous University of Hidalgo, Mexico SY-16(P-3)-3 Common variable immunodeficiency (CVID) Speaker: Kohsuke Imai Department of Pediatrics, Tokyo Medical and Dental University (TMDU), Japan

Symposium 17 p.550 Symposium SY-17(M-3)-1 Epidemiology Speaker: Margitta Worm Allergig-Centrum-Charité, Charité-Universitätsmedizin Berlin, Germany SY-17(M-3)-2 Insect venom allergy around the world Speaker: Michael Levin University of Cape Town, South Africa SY-17(M-3)-3 Countermeasures of anaphylaxis: how does it impact in clinical practice? Speaker: Luciana Kase Tanno Division of Allergy, Department of Pulmomulogy, University Hospital of Montpellier, France

Symposium 18 p.551

Treatment Adherence SY-18(M-4)-1 Adherence to topical treatment Speaker: Steven Feldman Department of Dermatology, Wake Forest School of Medicine, USA SY-18(M-4)-2 Adherence to inhaled corticosteroids in children and adolescents Speaker: Takao Fujisawa Allergy Center, Mie National Hospital, Japan SY-18(M-4)-3 Adherence to allergen specific immunotherapy Speaker: Ralph Mösges Department of Clinical Research International, University at Cologne, Germany

Symposium 19 p.552

New Insights in Allergen Immunotherapy: Adult SY-19(I-5)-1 New insights in allergen immunotherapy: adult Speaker: Giovanni Passalacqua Allergy and Respiratory Diseases, University of Genoa, Italy SY-19(I-5)-2 Allergen immunotherapy: an American perspective Speaker: Bryan Martin Department of Internal Medicine, The Ohio State University, USA SY-19(I-5)-3 Allergen immunotherapy in Japan Speaker: Makoto Nagata Department of Respiratory Medicine/Allergy Center, Saitama Medical University, Japan

Symposium 20 p.553

Non-IgE Food Allergy SY-20(P-4)-1 Non-IgE-mediated gastrointestinal food allergy in Japan Speaker: Ichiro Nomura Division of Eosinophilic Gastrointestinal Disorders, National Research Institute for Child Health and Development; Allergy Center, National Center for Child Health and Development, Japan SY-20(P-4)-2 Food protein-induced enterocolitis syndrome in USA Speaker: Anna Nowak-Wegrzyn Department of Pediatrics, New York University Langone Health, USA SY-20(P-4)-3 Non IgE-mediated food Speaker: Alessandro Fiocchi Department of Allergy, Pediatric Hospital Bambino Gesú IRCCS, Italy

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Symposium 21 p.554

Chronic Cough SY-21(I-6)-1 Pathophysiology and treatment of cough in asthma Speaker: Akio Niimi Department of Respiratory Medicine, Allergy and Clinical Immnology, City University, Japan SY-21(I-6)-2 Chronic cough in children Speaker: Anne Chang Department of Respiratory Medicine, Queensland Children's Hospital; Centre for Children's Health Research, Queensland University of Technology; Menzies School of Health Research, Charles Darwin University, Australia SY-21(I-6)-3 Management of chronic refractory cough Speaker: Kian Fan Chung National Heart & Lung Institute, Imperial College London & Royal Brompton Hospital, UK

Symposium 22 p.555

Food Allergy Diagnosis SY-22(P-5)-1 Molecular features of food : from mechanisms to diagnosis and therapy Speaker: Rudolf Valenta Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria SY-22(P-5)-2 Application of allergen component Speaker: Komei Ito Aichi Children's Health and Medical Center, Japan SY-22(P-5)-3 Stepwise oral food challenge Speaker: Noriyuki Yanagida Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan

Symposium 23 p.556 Symposium

Microbiome and Allergy SY-23(B-4)-1 Exposure to environmental microbes - from the hygiene hypothesis to a mechanistic understanding Speaker: Harald Renz Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg; University Hospital Giessen and Marburg GmbH, Germany SY-23(B-4)-2 Lung and gut microbiota in asthma - bacteria, viruses, fungi and archaea Speaker: Milena Sokolowska Swiss Institute of Allergy and Asthma Research, University of Zurich, Switzerland SY-23(B-4)-3 Intestinal bacteria promote intestinal barrier integrity and modulate retinoic acid metabolism to prevent allergic responses to food Speaker: Cathryn Rose Nagler Department of Pathology/Biological Sciences Division and Pritzker School of Molecular Engineering, The University of Chicago, USA

Symposium 24 p.557

Aspirin-Exacerbated Respiratory Disease (AERD) SY-24(I-7)-1 Role of inflammatory cells and lipid mediators in AERD pathogenesis Speaker: Sven-Erik Dahlen Centre for Allergy Research, Karolinska Institutet, Sweden SY-24(I-7)-2 Pathophysiology of phenotype/endotype of AERD Speaker: Hae-Sim Park Department of Allergy & Clinical Immunology, Ajou University Medical Center, Republic of Korea SY-24(I-7)-3 Aspirin-exacerbated respiratory disease: clinical manifestations and therapeutic advances Speaker: Masami Taniguchi Center for Immunology and Allergology, Shonan Kamakura General Hospital, Japan

Symposium 25 p.558

Severe Cutaneous Allergic Reaction (SCAR) SY-25(D-3)-1 Pathogenesis of SCAR: necroptosis in Stevens-Johnson syndrome/toxic epidermal necrolysis Speaker: Riichiro Abe Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Japan SY-25(D-3)-2 From immune mechanism to treatment on SCAR Speaker: Wen-Hung Chung Department of Dermatology and Drug Clinical and Research Center, Chang Gung Memorial Hospital, Taiwan SY-25(D-3)-3 Diagnostic test and biomarkers in SCAR Speaker: Elizabeth J Phillips Medicine, Pharmacology, Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, USA

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Symposium 26 p.559

Key Player in Immune Regulation SY-26(B-5)-1 Revisiting the mechanism for AIT: roles of DCs in SLIT Speaker: Katsuaki Sato Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Japan SY-26(B-5)-2 Regulatory T cells in allergic diseases Speaker: Talal Chatila Division of Immunology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School, USA. SY-26(B-5)-3 Novel B cell subsets and immune regulation Speaker: Mübeccel Akdis Swiss Institute of Allergy and Asthma Research (SIAF), Switzerland

Symposium 27 p.560

Allergen Immunotherapy for SY-27(E-3)-1 Novel mechanisms of immune tolerance for allergen immunotherapy Speaker: Mohamed Shamji Imperial College London National Heart and Lung Institute; Asthma UK Centre in Allergic Mechanisms of Asthma, UK SY-27(E-3)-2 Allergen immunotherapy for Japanese cedar/cypress pollinosis Speaker: Mitsuhiro Okano Department of Otorhinolaryngology, International University of Health and Welfare Narita Hospital, Japan SY-27(E-3)-3 The EUFOREA model to improve care in allergic rhinitis Speaker: Peter Hellings Department of Otorhinolaryngology, KU Leuven, Belgium

Symposium Symposium 28 p.561

Pathogenesis and Treatment of Ocular Allergy: Past, Present, and Future SY-28(M-5)-1 Ocular allergy syndromes: common treatments practice in Europe Speaker: Jean-Luc Fauquert Pediatric Allergy Unit, Estaing University Hospital, France SY-28(M-5)-2 Treatment of severe in Japan, focus on immunosuppressive eye drops Speaker: Nobuyuki Ebihara Department of Ophthalmology, Juntendo University Urayasu Hospital, Japan SY-28(M-5)-3 Pathogenesis and future treatment of severe ocular allergic diseases Speaker: Ken Fukuda Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Japan

Symposium 29 p.562

Risk Factors for Pediatric Allergies SY-29(P-6)-1 Particulate matter as a risk factor in children with atopic dermatitis Speaker: Kangmo Ahn Department of Pediatrics, Samsung Medical Center, Republic of Korea SY-29(P-6)-2 Risk factors for pediatric allergies, food allergy Speaker: Philippe Eigenmann Department of Woman, Child and Adolescent, University Hospital of Geneva, Switzerland SY-29(P-6)-3 Risk factors for allergic asthma in children Speaker: Jiu-Yao Wang Center for Allergy and Clinical Immunology Research (ACIR) Department of Pediatrics, College of Medicine, National Cheng Kung University, Taiwan

Symposium 30 p.563

Severe Urticaria SY-30(D-4)-1 Pathogenesis of urticaria refractory to antihistamines Speaker: Michihiro Hide Department of Dermatology, Hiroshima University, Japan SY-30(D-4)-2 Diagnositic tests and biomarkers in severe urticaria Speaker: Sarbjit S Saini Johns Hopkins University, USA SY-30(D-4)-3 Current and future management of chronic urticaria Speaker: Mario Sánchez-Borges Allergy and Clinical Immunolgy, Centro Médico Docente La Trinidad, Venezuela

Symposium 31 p.564

Precision Medicine SY-31(M-6)-1 Allergen immunotherapy-AIT Speaker: Giorgio Walter Canonica Internal Medicine, Humanitas University & Research Hospital, Italy SY-31(M-6)-2 Atopic dermatitis Speaker: Kenji Kabashima Department of Dermatology, Kyoto University Hospital, Japan SY-31(M-6)-3 Genetic susceptibility to asthma in the era of precision medicine Speaker: Kathleen Barnes Colorado Center for Personalized Medicine, Department of Medicine, University of Colorado, USA

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Symposium 32 p.565

Learning from Birth Cohort Studies SY-32(P-7)-1 Early-life origins of COPD Speaker: Adnan Custovic National Heart and Lung Institute, Imperial College London, UK SY-32(P-7)-2 JECS and T-child study-cohort studies in Japan Speaker: Kiwako Yamamoto-Hanada Allergy Center, Medical Research Center for Japan Environment and Children's Study(JECS), National Center for Child Health and Development, Japan SY-32(P-7)-3 Early life gut microbiome in allergic diseases Speaker: Soo-Jong Hong Department of Pediatrics, Childhood Asthma and Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea

Symposium 33 p.566

Problem to be Solved in Adult Asthma SY-33(I-8)-1 Problem to be solved in adult asthma: onset and risk factor Speaker: Anahí Yáñez Department of Research, Allergy and Respiratory Disease Research Center, Argentina SY-33(I-8)-2 Asthma and COPD Overlap (ACO) Speaker: Takeshi Kaneko Department of Pulmonology, Yokohama City University Graduate School of Medicine, Japan SY-33(I-8)-3 Elderly asthma in the era of aged population Speaker: Yoon-Seok Chang Department of Internal Medicine, Seoul National University Bundang Hospital; Department of Internal Medicine, Seoul National University College of Medicine; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University, Republic of Korea Symposium Symposium 34 p.567

Food Allergy Treatment SY-34(P-8)-1 Oral immunotherapy for food allergy Speaker: Sakura Sato Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan SY-34(P-8)-2 Epicutaneous immunotherapy for the treatment of food allergy Speaker: Hugh A Sampson Department of Pediatrics, Icahn School of Medicine at Mount Sinai, USA SY-34(P-8)-3 New treatments in food allergies Speaker: Alessandro Fiocchi Department of Allergy, Pediatric Hospital Bambino Gesú IRCCS, Italy

Symposium 35 p.568

Eosinophilic Inflammation in Airways SY-35(I-9)-1 Control of eosinophilic airways inflammation by endogenous siglec ligands Speaker: Bruce S Bochner Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, USA SY-35(I-9)-2 Eosinophils, viruses and childhood asthma Speaker: James E Gern Departments of Pediatrics and Medicine, University of Wisconsin-Madison, USA SY-35(I-9)-3 Eosinophil ETosis-mediated extracellular traps and diseases Speaker: Shigeharu Ueki Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Japan

Symposium 36 p.569

Mechanism of Itch SY-36(D-5)-1 Pathogenesis of pruritus Speaker: Kenji Kabashima Department of Dermatology, Kyoto University Hospital, Japan SY-36(D-5)-2 Management of atopic dermatitis in special situations Speaker: Andreas Wollenberg Department of Dermatology, Ludwig-Maximilian University, Germany SY-36(D-5)-3 Mechanisms of pruritus Speaker: Martin Steinhoff Department of Dermatology, Translational Research Institute, Dermatology Institute, Hamad Medical Corporation; Qatar University, School of Medicine, Qatar; Weill-Cornell Medicine, USA

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Symposium 37 p.570

Drug Hypersensitivity and Desensitization SY-37(M-7)-1 Pathogenesis of severe drug reactions Speaker: Mario Sánchez-Borges Allergy and Clinical Immunology, Centro Médico Docente La Trinidad, Venezuela SY-37(M-7)-2 Beta-lactam allergy: provocation or predictive model Speaker: Pascal Demoly Department of Pulmonology, Division of Allergy, University Hospital of Montpellier, France SY-37(M-7)-3 Drug hypersensitivity and desensitization: update Speaker: Emilio Alvarez-Cuesta Division of Allergy, La Luz University Hospital, Spain

Symposium 38 p.571

New Insights in Allergen Immunotherapy: Pediatric SY-38(P-9)-1 New insights in allergen immunotherapy: pediatric Speaker: Sandra Nora González Díaz Regional Center of Allergy and Clinical Immunology, University Hospital Dr José Eleuterio González, Mexico SY-38(P-9)-2 Specific immunotherapy in Asian children Speaker: Hugo Van Bever Department of Paediatrics, National University of Singapore, Singapore SY-38(P-9)-3 Allergen immunotherapy in Japan: current status and future perspective Speaker: Mizuho Nagao Institute for Clinical Research, National Hospital Organization Mie National Hospital, Japan

Symposium 39 p.572

Symposium New ARIA SY-39(E-4)-1 Implementation of ARIA guidelines by ARIA score and mobile technology Speaker: Jean Bousquet Pulmonary Medicine at Montpellier University, France SY-39(E-4)-2 Treatment of AR based on new EUFOREA algorithm Speaker: Peter Hellings Department of Otorhinolaryngology, KU Leuven, Belgium SY-39(E-4)-3 ARIA care pathways for allergic rhinitis in Japan Speaker: Yoshitaka Okamoto Otorhinolaryngology, Chiba Rousai Hospital; Chiba University, Japan

Symposium 40 p.573

Mastocytosis SY-40(B-6)-1 Novel immunopharmacological interventions in mastocytosis Speaker: Francesca Levi-Schaffer Pharmacology & Experimental Therapeutics Unit, The Hebrew University of Jerusalem, Israel SY-40(B-6)-2 Mastocytosis: clinical spectrum of disease Speaker: Peter Arkwright Lydia Becker Institute of Immunology and Inflammation, The University of Manchester, UK SY-40(B-6)-3 Association to anaphylaxis Speaker: Frank Siebenhaar Department of Dermatology, Allergology, Charité-Universitätsmedizin Berlin, Germany

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Mini Symposium

Mini Symposium 1

Adult airway diseases MS1-1 Clinical phenotypes of allergic bronchopulmonary aspergillosis in Japan Tsuyoshi Oguma1,2）, Jun Tanaka1）, Koichiro Asano1,2）, Japan ABPM Research Program2） Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan1）; Japan Agency for Medical Research and Development, Japan2） MS1-2 Validation of new diagnostic criteria for allergic bronchopulmonary aspergillosis Naoki Okada, Tsuyoshi Oguma, Shigeaki Hattori, Asako Kitahara, Jun Tanaka, Katsuyoshi Tomomatsu, Yoshiki Shiraishi, Koichiro Asano Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan MS1-3 Optimal aspergillus fumigatus and Asp f 1 serum IgG cut-offs for the diagnosis of allergic bronchopulmonary aspergillosis Yuto Hamada1）, Yuma Fukutomi1）, Eiji Nakatani2）, Akemi Saito1）, Kentaro Watai1）, Yosuke Kamide1）, Kiyoshi Sekiya1）, Tadashi Nagai3）, Kazuki Harada4）, Yoshiki Shiraishi4）, Tsuyoshi Oguma4）, Koichiro Asano4）, Masami Taniguchi1,5） Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan1）; Division of Statistical Analysis, Research Support Center, Shizuoka General Hospital, Japan2）; Central Blood Institute, Japanese Red Cross Society, Japan3）; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan4）; Shonan Kamakura General Hospital Center for Immunology and Allergology, Japan5） MS1-4 Genetic impact of CDHR3 on the adult-onset of asthma and COPD Rie Shigemasa1）, Hironori Masuko1）, Kentaro Hyodo1）, Haruna Kitazawa1）, Jun Kanazawa1）, Yohei Yatagai1）, Hiroaki Iijima2）, Takashi Naito2）, Takefumi Saito3）, Tomomitsu Hirota4）, Mayumi Tamari4）, Tohru Sakamoto1）, Nobuyuki Hizawa1） Department of Pulmonary Medicine, University of Tsukuba, Japan1）; Tsukuba Medical Center, Japan2）; National Hospital Organization Ibaraki Higashi Hospital, Japan3）; Research Center for Medical Science, The Jikei University School of Medicine, Japan4） MS1-5 Cough-related referrals in patients with chronic cough Michael Weiner1,2,3）, Ziyue Liu2）, Jessica Weaver4）, Paul Dexter1,2,5）, Anna R Roberts1）, Ashley Griffith1）, Ishita Doshi4）, Jonathan Schelfhout4）, Vishal Bali4） Regenstrief Institute, Inc., USA1）; Indiana University, USA2）; Center for Health Information and Communication, US Department of Veterans Affairs, USA3）; Center for Observational and Real-World Evidence (CORE), Merck & Co., Inc., USA4）; Eskenazi Health, USA5） MS1-6 Pathophysiological features of bronchodilator responsive chronic cough Noriyuki Ohkura1）, Masaki Fujimura2）, Johsuke Hara1）, Miki Abo1）, Naohiko Ogawa1）, Takashi Sone1）, Hideharu Kimura1）, Kazuo Kasahara1） Respiratory medicine, Kanazawa University Hospital, Japan1）; Respiratory Medicine, National Hospital Organization Nanao Hospital, Japan2） iiSymposium Mini Mini Symposium 2

Adult asthma MS2-1 Increased YKL-40 associates with greater airflow limitation in severe asthma: an analysis from the Hokkaido Severe Asthma Cohort Study Hirokazu Kimura1）, Hironi Makita1）, Natsuko Taniguchi1）, Hiroki Kimura1）, Kaoruko Shimizu1）, Masaru Suzuki1）, Nozomu Takei1）, Munehiro Matsumoto1）, Houman Goudarzi1）, Masaharu Nishimura2）, Satoshi Konno1） Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan1）; Hokkaido Medical Research Institute for Respiratory Diseases, Japan2） MS2-2 Elevated serum free fatty acids may be a risk factor of adult onset asthma: Nagahama Sturdy Noriyuki Tashima1）, Hisako Matsumoto1）, Mariko Kogo1）, Natsuko Nomura1）, Chie Morimoto1）, Hironobu Sunadome1）, Tadao Nagasaki1）, Tsuyoshi Oguma1）, Yoshinari Nakatsuka2）, Kimihiko Murase2）, Takahisa Kawaguchi3）, Yasuharu Tabara3）,KazuoChin2）, Kazuhiro Sonomura3）, Fumihiko Matsuda3）, Toyohiro Hirai1） Department of Respiratory Medicine, Graduate School of Medicine Kyoto University, Japan1）; Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine Kyoto University, Japan2）; Center for Genomic Medicine, Graduate School of Medicine Kyoto University, Japan3） MS2-3 Utility of Hull airway reflux questionnaire for the evaluation of clinical features of severe asthma Ryota Kurokawa, Yoshihiro Kanemitsu, Kensuke Fukumitsu, Norihisa Takeda, Tomoko Tajiri, Hirino Nishiyama, Jennifer Maries Yap, Keima Ito, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University, Japan MS2-4 Clinical characteristics and biomarker for Japanese asthmatic patients with obesity Hiroki Tashiro, Koichiro Takahashi, Hironori Sadamatsu, Yuki Kurihara, Sinya Kimura, Naoko Aragane Department of Respiratory Medicine, Saga University Hospital, Japan MS2-5 Type 2 inflammation and lung function in fungal asthma with and without IgE sensitization to Aspergillus fumigatus Michiyoshi Imaoka Department of Internal Medicine, Matsuyama Kinen Hospital, Japan MS2-6 Contribution of inflammatory mediators from neutrophils and eosinophils on pulmonary function in elderly patients with asthma Kazuki Katayama1）, Tomoyuki Soma1,2）, Yoshitaka Uchida1,2）, Yuki Hoshino1,2）, Sachiko Miyauchi1,2）, Hidetoshi Iemura1,2）, Erika Naito1,2）, Ryu Sekiya1,2）, Kazuyuki Nakagome1,2）, Makoto Nagata1,2） Department of Respiratory, Saitama Medical University, Japan1）; Allergy Center, Saitama Medical University, Japan2） 478

Mini Symposium 3

Allergic skin diseases MS3-1 SMAD4-mediated TGF-β signaling suppresses Th1 and Th17 differentiation in the pathogenesis of psoriasis Jeong-Hwan Yoon1,2,4）, Eunjin Bae1,2,3）, Jin Soo Han4）, In-Kyu Lee1）, Ji Hyeon Ju5）, Yukari Okubo6）, Mizuko Mamura1,2） Biomedical Research Institute, Kyungpook National University Hospital, Republic of Korea1）; Department of Molecular Pathology, Tokyo Medical University, Japan2）; Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences and Faculty of Medicine, University of Tsukuba, Japan3）; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Republic of Korea4）; Department of Rheumatology, Seoul St Mary Hospital, Catholic University of Korea, Republic of Korea5）; Department of Dermatology, Tokyo Medical University, Japan6） MS3-2 SMAD4-mediated chronological regulation in allergic contact dermatitis Mizuko Mamura1,2）, Eunjin Bae1,2,3）, Jin Soo Han4）, In-kyu Lee2）, Ji Hyeon Ju5）, Yukari Okubo6）, Jeong-Hwan Yoon1,2,4） Department of Molecular Pathology, Tokyo Medical University, Japan1）; Biomedical research institute, Kyungpook National University Hospital, Republic of Korea2）; Department of Experimental Pathology, University of Tsukuba, Japan3）; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Republic of Korea4）; Department of Rheumatology, Seoul St Mary Hospital, Republic of Korea5）; Department of Dermatology, Tokyo Medical University, Japan6） MS3-3 Loss of cytoplasmic galectin-10 in eosinophil ETosis-mediated cytolysis Mineyo Fukuchi1）, Yosuke Kamide2）, Shigeharu Ueki1）, Yui Miyabe1）, Yasunori Konno1）, Nobuyuki Oka3）, Hiroki Takeuchi4）, Tomoo Saga1）, Rossana CN Melo5）, Peter F Weller6）, Masami Taniguchi2） Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Japan1）; National Hospital Organization Sagamihara National Hospital, Clinical Research Center, Kanagawa, Japan2）; Kyoto Konoe Rehabilitation Hospital, Japan3）; National Hospital Organization Minami Kyoto Hospital, Japan4）; Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Brazil5）; Divisions of Allergy and Inflammation and Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medic, USA6） MS3-4 Variants of TNFAIP3 gene are associated with psoriasis vulgaris and psoriasis arthritis in a Japanese population Tomomitsu Hirota1）, Mami Momose2）, Sota Kikuchi2）, Yoshinori Umezawa2）, Hidemi Nakagawa2）, Hidehisa Saeki3）, Natsuki Inoue1）, Mayumi Tamari1）, Akihiko Asahina2） Division of Molecular Genetics, Research Center for Medical Science, The Jikei University School of Medicine, Japan1）; Department of Dermatology, The Jikei University School of Medicine, Japan2）; Department of Dermatology, Nippon Medical School, Japan3） MS3-5 Improved FcεRI-mediated basophil reactivities reflect rapid-responses to omalizumab in chronic spontaneous urticaria Yoshiko Oda1）, Atsushi Fukunaga1）, Ken Washio2）, Mayuko Mizuno1）, Shinya Imamura1）, Chikako Nishigori1） Department of Dermatology, Kobe University Graduate School of Medicine, Japan1）; Department of Dermatology, Kobe city Nishi-Kobe medical center, Japan2） MS3-6 Effectiveness and safety of icatibant in patients with hereditary angioedema with normal C1-INH levels: findings from the Icatibant Outcome Survey (IOS) Anete S Grumach1）, Teresa Caballero2）, Marcus Maurer3）, Hilary J Longhurst4）, Andrea Zanichelli5）, Werner Aberer6）, Jaco Botha7）, Irmgard Andresen7）, Giorgio Giannattasio7）, Laurence Bouillet8） iiSymposium Mini Clinical Immunology, Medical School, University Center Health ABC, Brazil1）; Department of Allergy, Hospital Universitario La Paz, Biomedical Research Network on Rare Diseases (CIBERER, U754), Spain2）; Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedízin Berlin, Germany3）; Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, and University College London Hospitals, UK4）; Department of Biomedical and Clinical Sciences Luigi Sacco, University of Milan, ASST Fatebenefratelli Sacco, Italy5）; Department of Dermatology and Venereology, Medical University of Graz, Austria6）; Shire (a Takeda company), Switzerland7）; National Reference Centre for Angioedema, Internal Medicine Department, Grenoble University, Grenoble, France8）

Mini Symposium 4

Allergy prevention and risk factors MS4-1 Global Asthma Network (GAN): Prevalence of allergic rhinitis and atopic dermatitis and associated factors in Uruguaiana’s adolescents Marilyn Urrutia-Pereira1）, Herberto Chong Neto2）, Pietro Nunes Rinelli1）, Laura Simon1）, Philippa Ellwood3）, Luis García-Marcos4）, Dirceu Solé5） Federal University of Pampa, Brazil1）; Federal University of Parana, Brazil2）; University of Auckland, New Zealand3）; University of Murcia, Spain4）; Federal University of São Paulo, Brazil5） MS4-2 Vegetable dietary pattern may protect mild and persistent allergic rhinitis phenotype in schoolchildren Hea Young Oh1）, So-Yeon Lee1）, Min Jee Park1）, Sungsu Jung1）, Jisun Yoon1）, Hyun-Ju Cho2）, Song-I Yang3）, Eun Lee4）, Soo-Jong Hong1） Department of Pediatric, Asan Medical Center, Republic of Korea1）; Department of Pediatrics, International St Mary’s Hospital, Republic of Korea2）; Department of Pediatrics, Hallym University Sacred Heart Hospital, Republic of Korea3）; Department of Pediatrics, Chonnam National University Hospital, Republic of Korea4） MS4-3 Development of sandwich ELISAs for determination of Pru p 3 and Pru p 7 Fumiko Okazaki1）, Yukie Yamaguchi-Murakami2）, Takuya Morimoto3）, Akihiro Itai3）, Hiroshi Narita2） Faculty of Agriculure, Ryukoku University, Japan1）; Kyoto College of Nutritional and Medical Sciences, Japan2）; Kyoto Prefectural University, Japan3） MS4-4 Breastfeeding is a risk factor of egg white sensitization Taiji Nakano, Fumiya Yamaide, Naoki Shimojo Department of Pediatrics, Graduate School of Medicine, Chiba University, Japan MS4-5 Egg introduction with the existence of eczema promotes sensitization to egg at the age of 12 months Masaki Futamura1,2）, Matsuo Yamamoto2）, Noriyuki Yanagida3）, Tsuneo Igarashi4）, Takanori Yanai5）, Isamu Kamimaki6）, Motoki Bonno7）, Toshinori Nakashima8） Department of Pediatrics, National Hospital Organization Nagoya Medical Center, Japan1）; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Japan2）; Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan3）; Department of Pediatrics, National Hospital Organization Takasaki General Medical Center, Japan4）; Department of Pediatrics, National Hospital Organization Yokohama Medical Center, Japan5）; Department of Pediatrics, National Hospital Organization Saitama Hospital, Japan6）; Clinical Research Institute and Department of Pediatrics, National Hospital Organization Mie Chuo Medical Center, Japan7）; Department of Pediatrics, National Hospital Organization Kokura Medical Center, Japan8） 479

MS4-6 Development of a Skin Barrier Meter to measure skin barrier functions: A pilot study in human healthy adults Hiroya Ogita1）, Kiwako Yamamoto-Hanada1）, Kazue Yoshida1,2）, Osamu Uehara3）, Yuya Funaki3）, Masushi Kohta3）, Yukihiro Ohya1） Allergy Center, National Center for Child Health and Development, Japan1）; Department of Dermatology, National Center for Child Health and Development, Japan2）; Medical Engineering Laboratory, ALCARE Co., Ltd., Japan3）

Mini Symposium 5

Anaphylaxis MS5-1 Follow-up of 121 patients with wheat-dependent exercise-induced anaphylaxis in China Zhirong Du, Jia Yin Department of Allergy, Peking Union Medical College Hospital, China MS5-2 Difference in ED visits for Anaphylaxis due to Food Allergies between pediatric patients who live in urban and rural areas in the U.S. Karin Oshima1,2,3）, Rie Sakai-Bizmark2,4）, Yoshikazu Ohtsuka1） Department of Pediatrics and Adolescent Medicine, Juntendo University, School of Medicine, Japan1）; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, USA2）; Department of Pediatrics, Tokyo Metropolitan Health and Hospitals Corporation, Japan3）; Department of Pediatrics, Harbor-UCLA Medical Center and the David Geffen School of Medicine, University of California at Los Angeles, USA4） MS5-3 The prevalence and characteristics of childhood anaphylaxis in Aichi prefecture, Japan Katsumasa Kitamura1）, Tomoya Ito1,2）, Komei Ito1） Aichi Children’s Health and Medical Center, Japan1）; Committee of Emergency Medicine, Aichi Medical Association, Japan2） MS5-4 IgE-binding patterns to influenza hemagglutinin in IgE-induced adverse reactions after influenza vaccination Prince Baffour Tonto, Keigo Kainuma, Miyuki Hoshi, Kana Hamada, Mayumi Matsunaga, Kazutaka Nogami, Shingo Yamada, Mizuho Nagao, Takao Fujisawa Institute for Clinical Research, National Hospital Organization Mie National Hospital, Japan MS5-5 Fish collagen as a marker for the detection of severe fish allergies Naoshi Shimojo1,2）, Akiko Yagami3,4）, Masashi Nakamura1,2）, Kayoko Suzuki3,4）, Kyoko Futamura3,4）, Kazunobu Kuwabara4,5）, Satoshi Ohno6）, Takahiko Horiguchi4,5）, Kayoko Matsunaga1,3） Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Japan1）; General Research and Development Institute, Hoyu Co., Ltd., Japan2）; Department of Allergology, Fujita Health University School of Medicine, Japan3）; Fujita Health University General Allergy Center in Bantane Hospital, Japan4）; Department of Respiratory Medicine II, Fujita Health University School of Medicine, Japan5）; Faculty of Engineering, Gifu University, Japan6） MS5-6 Assessment of the pharmacokinetics, pharmacodynamics, and safety of low dose intra-nasal epinephrine (ARS-1) with intramuscular by needle-syringe and EpiPen in patients with induced allergic rhinitis Motohiro Ebisawa1）, Richard E Lowenthal2）, Sarina Tanimoto2） Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Japan1）; ARS Pharmaceuticals, Inc., USA2）

Mini Symposium 6 Symposium Mini

Asthma-Basics MS6-1 Non-neuronal TRPA1 modulates fibroblast-myofibroblast transition in human lung fibroblasts Jennifer Maries Yap1）, Takashi Ueda2）, Norihisa Takeda1）, Kensuke Fukumitsu1）, Satoshi Fukuda1）, Takehiro Uemura1）, Tomoko Tajiri1）, Hirotsugu Ohkubo1）, Ken Maeno1）, Yutaka Ito1）, Testsuya Oguri1）, Yoshihiro Kanemitsu1）, Akio Niimi1） Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Japan1）; Department of Anatomy and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Japan2） MS6-2 Hyaluronan synthase 2 attenuates airway inflammation and remodeling in an ovalbumin induced chronic mouse model of asthma Mingma Sherpa, Takumi Kiwamoto, Yoshiya Tsunoda, Hajime Osawa, Kazufumi Yoshida, Masayuki Nakajima, Masashi Matsuyama, Yosuke Matsuno, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa Department of Pulmonary Medicine, University of Tsukuba, Japan MS6-3 TLR pathway genes may contribute to asthma in association with upper airway microbiota Purevsuren Losol1,2,3）, Jun-Pyo Choi1,2）, Yong Hyun Kim1,2）, Sae-Hoon Kim1,2,3）, Sang-Heon Cho2,3）, Yoon-Seok Chang1,2,3） Department of Internal Medicine, Seoul National University Bundang Hospital, Republic of Korea1）; Department of Internal Medicine, Seoul National University College of Medicine, Republic of Korea2）; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Council, Republic of Korea3） MS6-4 Osteopontin enhances airway remodeling in late-onset asthma by upregulating Smad3/transforming-growth factor β1 Hoang Kim Tu Trinh1,2）, Thao Thuy Van Nguyen3）, Seo-Hee Kim4）, Tra Thi Bich Cao5）, Quang Quoc Luu5）, Seung-Hyun Kim6）, Hae-Sim Park2,5） Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam1）; Department of Allergy and Clinical Immunology, Ajou University Medical Center, Republic of Korea2）; Department of Pediatrics, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam3）; Department of Biomedical Science, Graduate School of Ajou University, Republic of Korea4）; Department of Biomedical Science, Ajou University School of Medicine, Republic of Korea5）; Translational Research Laboratory for Inflammatory Disease, Clinical Trial Center, Ajou University Medical Center, Republic of Korea6） MS6-5 Effect of cadherin-related family member 3 on the effector functions of eosinophils Kazuyuki Nakagome1）, Toshiaki Shimizu1）, Yury A Bochkov2）, Toru Noguchi1）, Takehito Kobayashi1）, Tomoyuki Soma1）, James E Gern2,3）, Makoto Nagata1） Department of Respiratory Medicine and Allergy Center, Saitama Medical University, Japan1）; Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin, USA2）; Department of Medicine, School of Medicine and Public Health, University of Wisconsin, USA3） 480

MS6-6 ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization Haruna Kitazawa1）, Hironori Masuko1）, Jun Kanazawa1）, Rie Shigemasa1）, Kentaro Hyodo1）, Hideyasu Yamada1）, Yohei Yatagai1）, Yoshiko Kaneko1）, Hiroaki Iijima2）, Takashi Naito2）, Takefumi Saito3）, Emiko Noguchi4）, Satoshi Konno5）, Tomomitsu Hirota6）, Mayumi Tamari6）, Tohru Sakamoto1）, Nobuyuki Hizawa1） Department of Pulmonary Medicine, University of Tsukuba, Japan1）; Department of Pulmonary Medicine, Tsukuba Medical Center, Japan2）; Department of Pulmonary Medicine, National Hospital Organization Ibarakihigashi National Hospital, Japan3）; Department of Medical Genetics, University of Tsukuba, Japan4）; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan5）; Research Center for Medical Science, The Jikei University School of Medicine, Japan6）

Mini Symposium 7

Atopic dermatitis MS7-1 Implications of dermal IL-31 from M2 macrophages in itch in murine models of atopic dermatitis Takashi Hashimoto1,2）, Takahiro Satoh1） Department of Dermatology, National Defense Medical College, Japan1）; Department of Dermatology, Tokyo Medical and Dental University, Japan2） MS7-2 IL-24 has a key role in improving skin barrier dysfunctions via aryl hydrocarbon receptor activation in atopic dermatitis YenHVu1）, Gaku Tsuji1,2）, Akiko Hashimoto-Hachiya1）, Takeshi Nakahara1,3）, Masutaka Furue1,2,3） Department of Dermatology, Graduate School of Medical Sciences, , Japan1）; Research and Clinical Center for Yusho and Dioxin, Kyushu University, Japan2）; Division of Skin Surface Sensing, Graduate School of Medical Sciences, Kyushu University, Japan3） MS7-3 Stratum corneum squamous cell carcinoma antigen 2 (SCCA2) correlates the severity of atopic dermatitis Mari Nakanishi1）, Risa Tamagawa-Mineoka1）, Naomi Nakamura1）, Risa Yasuike1）, Koji Masuda1）, Kenji Izuhara2）, Yoshinori Azuma3）, Hiroshi Matsunaka4）, Yumi Murakami4）, Emiko Yokosawa4）, Norito Katoh1） Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Japan1）; Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Japan2）; Shino-Test Corporation, Japan3）; Research & Development, TOKIWA Pharmaceutical Co., Ltd. NOV Academic Research, Japan4） MS7-4 Transcriptome analysis of non-invasively collected skin surface lipids provides insights into pathophysiology of atopic dermatitis in infants Kyoko Shima, Maeko Iwamura, Satoko Fukagawa, Yuya Uehara, Takayoshi Inoue, Noriyasu Ota, Takatoshi Murase Biological Science Research, Kao Corporation, Japan MS7-5 Distinct molecular features of nonlesional and lesional skin of atopic dermatitis compared to healthy skin: role of bone morphogenetic protein 6 Yasutaka Mitamura, Arturo O Rinaldi, Cezmi A Akdis Swiss Institute of Allergy and Asthma Research, Switzerland MS7-6 Relationship between skin barrier condition and regulatory T cell distribution in a mouse model of skin barrier disruption Sumika Toyama1）, Catharina Sagita Moniaga1）, Mitsutoshi Tominaga1,2）, Kenji Takamori1,2,3） iiSymposium Mini Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Japan1）; Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, Japan2）; Department of Dermatology, Juntendo University Urayasu Hospital, Japan3）

Mini Symposium 8

Clinical Immunology MS8-1 Circulating cell free DNA as a biomarker in Eosinophilic granulomatosis with polyangiitis Teppei Hashimoto1）, Shigeharu Ueki2）, Yosuke Kamide3）, Yui Miyabe2）, Yuichi Yokoyama1）, Tetsuya Furukawa1）, Naoto Azuma1）, Masami Taniguch3）, Tomoo Saga2）, Akira Hashiramoto4）, Kiyoshi Matsui1） Division of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo college of Medicine, Japan1）; Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Japan2）; National Hospital Organization Sagamihara National Hospital, Clinical Research Center, Japan3）; Department of Biophysics, Kobe University Graduate School of Health Sciences, Japan4） MS8-2 Treatment response of peripheral neuropathy associated with eosinophilic granulomatosis with polyangiitis Ryo Morishima1）, Naoki Tanomogi2）, Naoto Yokogawa2）, Toshio Shimizu1） Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan1）; Department of Rheumatology, Tokyo Metropolitan Tama Medical Center, Japan2） MS8-3 Numbers of eosinophils in peripheral blood at disease onset of patients with active eosinophilic granulomatosis with polyangiitis may predict clinical efficacy of mepolizumab Naomi Tsurikisawa1,2）, Chiyako Oshikata1,2）, Takeshi Kaneko2） Department of Allergy, Hiratsuka City Hospital, Japan1）; Department of Pulmonology, Yokohama City University Graduate School of Medicine, Japan2） MS8-4 Long-term safety and effectiveness of berotralstat (BCX7353) for the prophylaxis of hereditary angioedema (HAE) attacks: results from the APeX-S study Adrian Wu1）, Jonathan Peter2）, Avner Reshef3）, Marcus Maurer4）, Sorena Kiani5）, Marcin Stobiecki6）, Tamar Kinaciyan7）, Emel Aygören-Pürsün8）, Jessica Best9）, Melanie Cornpropst9）, Kusumam Joseph9）, Eniko Nagy9）, Sharon Murray9）, William P Sheridan9）, Henriette Farkas1） Centre for Allergy and Asthma, Hong Kong1）; UCT Lung Institute, South Africa2）; Barzilai Medical Center, Israel3）; Charité-Universitätsmedizin Berlin, Germany4）; Barts Health NHS Trust, UK5）; Krakowie Centrum Alergologii, Poland6）; Medical University of Vienna, Austria7）; University Hospital Frankfurt, Goethe University, Germany8）; BioCryst Pharmaceuticals, Inc, USA9）; Semmelweis University, Hungary10） MS8-5 Comparison of consultation behavior at acute attacks before and after prescription of bradykinin B2 receptor antagonist (Icatibant) in patients with hereditary angioedema Daisuke Honda1）, Isao Ohsawa1,2）, Yasuhiko Tomino1,3）, Yusuke Suzuki1） Department of Nephrology, Juntendo University Faculty of Medicine, Japan1）; Nephrology Unit, Internal Medicine, Saiyu Soka Hospital, Japan2）; Medical Corporation SHOWAKAI, Japan3） 481

MS8-6 Characterization of the biomarkers affecting the clinical course and outcomes of juvenile dermatomyositis Ting-Wei Lin, Ya-Chiao Hu, Bor-Luen Chiang Department of Pediatrics, National Taiwan University Hospital, Taiwan

Mini Symposium 9

Drug hypersensitivity MS9-1 Exosomes from drug-induced Stevens-Johnson syndrome/Toxic epidermal necrolysis can induce keratinocyte cell death Nithikan Suthumchai1,2）, Supranee Buranapraditkul1）, Pattarawat Thantiworasit1）, Jongkonneew Wongpiyabovorn2）, Pawinee Rerknimitr3）, Rangsima Reantragoon2）, Jettanong Klaewsongkram1） Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, The Skin and Allergy Research Unit, Chulalongkorn University, Thailand1）; Department of Immunology, Faculty of Medicine, Chulalongkorn University, Thailand2）; Division of Dermatology, Department of Medicine, Faculty of Medicine, The Skin and Allergy Research Unit, Chulalongkorn University, Thailand3） MS9-2 A novel Q-probe method for the detection of specific HLA directly from blood samples in drug hypersensitivity patients Kunie Kohno, Hiroyuki Niihara, Eishin Morita Department of Dermatology, Shimane University, Japan MS9-3 The prevalence and features of systemic hypersensitivity reactions to drug skin prick tests Yong-Hyun Kim1）, Seung-Teak Lee2）, Kyung-Min Ahn1）, Bomi Seo2）, Sae-Hoon Kim2）, Sang-Heon Cho1,3）, Yoon-Seok Chang2） Department of Internal Medicine, Seoul National University College of Medicine, Republic of Korea1）; Department of Internal Medicine, Seoul National University Bundang Hospital, Republic of Korea2）; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Council, Republic of Korea3） MS9-4 Diagnosis of non-immediate hypersensitivity reactions to amoxicillin in children using a skin test and drug provocation test Yukiko Katoh, Osamu Natsume, Mayumi Matsunaga, Fumitaka Takayanagi, Ryuhei Yasuoka Department of Pediatrics, Hamamatsu Univercity School of Medicine, Japan MS9-5 Prevalence, incidence and sensitization patterns of beta-lactam allergy in Hong Kong Philip H Li1）, Heather HF Yeung2）, Chak-sing Lau1）, Elaine YL Au2） Department of Medicine, University of Hong Kong, Hong Kong1）; Division of Clinical Immunology, Department of Pathology, Queen Mary Hospital, Hong Kong2） MS9-6 The growing dilemma of piperacillin-tazobactam allergies: an exception to usual penicillin allergy testing Jane Chi Yan Wong, Philip Hei Li Department of Medicine, Division of Rheumatology & Clinical Immunology, Queen Mary Hospital, Hong Kong

Mini Symposium 10

Food allergy-Allergen and IgE Symposium Mini MS10-1 Effects of different cooking methods on grass carp allergens Kary JY Xu, Nicki YH Leung, Agnes SY Leung, Christine YY Wai, Maco CY Lam, Nicole PF Li, Gary WK Wong, Ting Fan Leung Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong MS10-2 Serologic evaluation of the allergenicity of ω-5 gliadins deficiency wheat cultivar extracts Jung-Won Park1,2）, Kyung-Hee Park1,2）, Kyoung Yong Jeong2）, Jae-Hyun Lee1,2）, Chon-Sik Kang3）, Kyeong-Hoon Kim3） Department of Internal medicine, Severance Hospital, Republic of Korea1）; Institute of Allergy, Yonsei Univ., Republic of Korea2）; National Institute of Crop Science, Republic of Korea3） MS10-3 IgE-reactivity against gilthead seabream (sparus aurata) Pedro Miguel Rodrigues1）, Denise Schrama1）, Cláudia Raposo de Magalhães1）, Annette Kuehn2） University of Algarve, Centre of Marine Sciences (CCMAR), Portugal1）; Luxembourg Institute of Health, Department of Infection and Immunity, Luxembourg2） MS10-4 Expression analysis of gibberellin-regulated protein in fruits and vegetables by real-time PCR Keiko Momma1）, Natsuki Kawai2）, Shinya Matsumoto1）, Yuki Hirakawa1）, Takuya Morimoto3）, Akihiro Itai3）, Yasuo Kondo4）, Hiroshi Narita2） Kyoto Women’s University, Japan1）; Kyoto College of Nutritional and Medical Sciences, Japan2）; Kyoto Prefectural University, Japan3）; Fujita Health University, Japan4） MS10-6 Cross-allergenicity of crustacean and the edible insect Gryllus bimaculatus in patients with shrimp allergy Mayumi Sugimoto1）, Norio Kamemura2）, Norimasa Tamehiro3）, Reiko Adachi3）, Sayuri Tomonari4）, Takahiro Watanabe4）,TaroMito4） Department of Pediatrics, Tokushima University Hospital, Japan1）; Department of Food-Nutritional Sciences, Tokushima Bunri University, Japan2）; Division of Biochemistry, National Institute of Health Sciences, Japan3）; Division of Bioscience and Bioindustry, Tokushima University, Japan4）

Mini Symposium 11

Food allergy-Clinical aspects 1 MS11-1 Gut microbiome alterations in patients with wheat-dependent exercise-induced anaphylaxis Zhirong Du, Jia Yin Department of Allergy, Peking Union Medical College Hospital, China MS11-2 Decreased butyric acid-producing bacteria in the gut microbiome of children with Shohei Akagawa1）, Mitsuru Yamagishi1）, Yuko Akagawa1）, Yoko Nakai1）, Tadashi Yamaguchi1）, Masaki Hashiyada2）, Shoji Tsuji1）, Atsushi Akane2）, Kazunari Kaneko1） Department of Pediatrics, Kansai Medical University, Japan1）; Department of Legal Medicine, Kansai Medical University, Japan2） MS11-3 Microbiome analysis for food allergy in Japanese population Hisato Suzuki1,2）, Wataru Morii1）, Daisuke Hayashi3）, Emiko Noguchi1） Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Japan1）; Center for Medical Genetics, Keio University, Japan2）; Department of Pediatrics, Tsukuba Medical Center Hospital, Japan3） 482

MS11-4 Effect of allergic profiles on baseline urinary prostaglandin D2 metabolites Yusuke Inuzuka1）, Kiwako Yamamoto-Hanada1）, Limin Yang1）, Yoshitsune Miyagi1）, Koji Nishimura1）, Fumi Ishikawa1）, Shinichiro Inagaki1）, Yumiko Miyaji1）, Shigenori Kabashima1）, Masami Narita1）, Tatsuro Nakamura2）, Tatsuo Shimosawa3）, Takahisa Murata2）, Yukihiro Ohya1） Allergy Center, National Center for Child Health and Development, Japan1）; Department of Animal Radiology, Graduate School of Agriculture and Life Science, The , Japan2）; Department of Clinical Laboratory, International University of Health and Welfare, Japan3） MS11-5 Neonatal intensive care unit demographics and subsequent development of food allergy Emily Robbins1）, Seleshi Demissie2）, Jonathan Blau1）, Courtney Briggs-Steinberg1） Department of Pediatrics, Staten Island University Hospital North, USA1）; Department of Research, Staten Island University Hospital North, USA2） MS11-6 Association between cow’s milk protein intake and risk for cow’s : a prospective observation study Iwata Mihoko, Satoshi Honjou, Kaoru Kojima, Makiko Oda, Takeshi Oki, Toshiaki Kawano, Kouki Okabe, Masatoshi Wakatsuki, Takahito Ninomiya, Yuko Akamine, Naohiko Taba, Chikako Motomura, Hiroshi Odajima Department of Pediatric, Fukuoka National Hospital, Japan

Mini Symposium 12

Food allergy-Clinical aspects 2 MS12-1 Characteristics of fish-allergic patients in Hong Kong Agnes Sze Yin Leung1）, Nicki Yat Hin Leung1）, Christine Yee Yan Wai1,2）, Kary Jiaying Xu1）, Maco Cheuk Yin Lam1）, Gary Wing Kin Wong1）, Ting Fan Leung1,2） Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong1）; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong2） MS12-2 More than two third of shrimp allergy children acquire tolerance at 10 years of age Hironaga Yoshimoto1）, Kyohei Takahashi1）, Noriyuki Yanagida1）, Sakura Sato2）, Motohiro Ebisawa2） Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2） MS12-3 Is it more difficult to induce oral tolerance in cow’s milk allergy than in hen’s egg allergy? Osamu Natsume, Fumitaka Takayanagi, Hiroyuki Uchida, Yukiko Kato, Yuko Mizoguchi, Ryuhei Yasuoka Department of Pediatrics, Hamamatsu University School of Medicine, Japan MS12-4 Investigation of the optimal medium-dose egg oral food challenge method in children with positive ovomucoid-specific IgE Kyohei Takahashi1）, Noriyuki Yanagida1）, Makoto Nishino1）, Tomonori Asaumi1）, Ken-ichi Nagakura1）, Kiyotake Ogura1）, Sakura Sato2）, Motohiro Ebisawa2） Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2） MS12-5 The prevalence and risk factors of peanut allergy of children and adults in Taiwan Kuan-Wen Su1,2）, Dah-Chin Yan Yan2,3）, Li-Lun Lin3）, Liang-Shiou Ou2,4）, Tsung-Chieh Yao2,4）, Kuo-Wei Yeh2,4）, Jing-Long Huang5） iiSymposium Mini Department of Pediatrics, Keelung Chang Gung Memorial Hospital, Taiwan1）; Chang Gung University College of Medicine, Taiwan2）; Department of Pediatrics, Taipei Chang Gung Memorial Hospital, Taiwan3）; Linkou Chang Gung Memorial Hospital, Taiwan4）; New Taipei Municipal TuCheng Hospital, Chang Gung Memorial Hospital and Chang Gung University, Taiwan5） MS12-6 Most of the hazel nut sensitized children do not evoke symptoms: from the results of 39 oral food challenge tests Teruaki Matsui, Katsumasa Kitamura, Yoshihiro Takasato, Shiro Sugiura, Komei Ito Department of Allergy, Aichi Children’s Health and Medical Center, Japan

Mini Symposium 13

Food allergy-Clinical aspects 3 MS13-1 Sensitization to Cry j 1 at 5 years age and male sex are associated with sensitization to Mal d 1 at 13 years Makoto Irahara, Kiwako Yamamoto-Hanada, Yoshitsune Miyagi, Hiroya Ogita, Tomoyuki Kiguchi, Yusuke Inuzuka, Kenji Toyokuni, Koji Nishimura, Fumi Ishikawa, Miori Sato, Mayako Saito-Abe, Yumiko Miyaji, Shigenori Kabashima, Tatsuki Fukuie, Yukihiro Ohya Allergy Center, National Center for Child Health and Development, Japan MS13-2 Pollen-Food Allergy Syndrome (PFAS) in adolescents: a Birth Cohort (T-Child Study) Tomoyuki Kiguchi, Kiwako Yamamoto-Hanada, Hiroya Ogita, Yoshitsune Miyagi, Yusuke Inuzuka, Kenji Toyokuni, Koji Nishimura, Makoto Irahara, Fumi Ishikawa, Miori Sato, Yumiko Miyaji, Mayako Saito-Abe, Tatsuki Fukuie, Ichiro Nomura, Yukihiro Ohya Allergy Center, National Center for Child Health and Development, Japan MS13-3 Sensitization rate for Gibberellin-Regulated Protein (GRP) in patients with Japanese cedar pollen allergy Yuji Mori1）, Fumiko Okazaki2）, Yasuaki Yasuda1）, Keiko Momma3）, Hiroshi Narita4）, Yasuto Kondo1） Department of Pediatrics, School of Medicine, Fujita Health University, Japan1）; Department of Food Science and Human Nutrition Faculty of Agriculture Ryukoku University, Japan2）; Department of Food Science, Kyoto Women’s University, Japan3）; Kyoto College of Nutritional and Medical Sciences, Japan4） MS13-4 Comparison of pollen and pollen fruit allergy syndrome in Eastern Asia’s three cities Yoon Ha Hwang1）, Chikako Motomura2）, Hironobu Fukuda3）, Shigemi Yoshihara3）, Reiko Kishikawa4）, Naoto Watanabe5） Department of Pediatrics, Busan St Mary’s Hospital, Republic of Korea1）; Department of Pediatrics, National Hospital Organization Fukuoka National Hospital, Japan2）; Department of Pediatrics, Dokkyo Medical University Hospital, Japan3）; Department of Allergy, National Hospital Organization Fukuoka Hospital, Japan4）; Medical Center for Allergic and Immune Disease, Yokohama City Minato Red Cross Hospital, Japan5） MS13-5 Cross-reactivity between salmon roe and pollock roe allergens Yoshihiro Takasato, Katsumasa Kitamura, Teruaki Matsui, Shiro Sugiura, Komei Ito Department of Allergy, Aichi Children’s Health and Medical Center, Japan MS13-6 Double-blind, placebo-controlled food challenges with apple in pollen-food allergy syndrome patients Yumi Koike1）, Mai Tokunaga2）, Katsuhiko Kobayash3）, Naoko Okishima4） Department of Allergy, Nagano Children’s Hospital, Japan1）; Department of Allergy, Nagano Children’s Hospital, Japan2）; Kobayashi Otolaryngology Clinic, Japan3）; Faculty of Human Health and Science Department of Health and Nutritional Science, Matsumoto University, Japan4） 483

Mini Symposium 14

Food allergy-GI and mechanisms MS14-1 Cluster analysis using a diagnostic panel of serum multiple allergen-specific immunoglobulin E in patients with eosinophilic esophagitis Yasuhiro Fujiwara, Akinobu Nakata, Fumio Tanaka Department of Gastroenterology, Osaka City University, Japan MS14-2 Analysis of causative in mice food allergy model by percutaneous sensitization of hydrolyzed wheat protein Daiki Tokumitsu1）, Shotaro Obinata1）, Kazumi Sasaki2）, Hanako Ataku2）, Nayu Sato3,4）, Masashi Nakamura3,4）, Hirotaka Yamashita1,5）, Naoki Inagaki6）, Eichi Hinoi1,5）, Akiko Yagami7,8）, Kayoko Matsunaga3）, Hiroyuki Tanaka1,5） Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan1）; Department of Biological Resource Center, National Institute of Technology and Evaluation, Japan2）; Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Japan3）; General Research and Development Institute Hoyu Co., Ltd., Japan4）; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Japan5）; Faculty of Health Sciences, Gifu University of Medical Science, Japan6）; Department of Allergology, Fujita Health University School of Medicine, Japan7）; Fujita Health University General Allergy Center in Bantane Hospital, Japan8） MS14-3 Food protein-induced enterocolitis syndrome due to egg yolk and egg white in Japanese infants Makoto Nishino1,3）, Noriyuki Yanagida1）, Sakura Sato2,3）, Ken-ichi Nagakura1）, Kyouhei Takahashi1,3）, Kiyotake Ogura1）, Motohiro Ebisawa2） Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2）; Course of Allergy and Clinical Immunology, Juntendo University Graduate School of Medicine, Japan3） MS14-4 Chitinase 3-like 1 contributes to food allergy via M2 macrophage polarization Eun Gyul Kim1,2）,MiNaKim1）, Jung Yeon Hong1）, Jae Woo Lee1）, Soo Yeon Kim1）, Kyung Won Kim1）, Chun Geun Lee3,4）, Jack A Elias3）, Tae Won Song2）, Myung Hyun Sohn1） Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Republic of Korea1）; Department of Pediatrics, Ilsan Paik Hospital, Inje University College of Medicine, Republic of Korea2）; Molecular Microbiology and Immunology, Brown University, USA3）; Department of Internal Medicine, Hanyang University, Republic of Korea4） MS14-5 Gene expression in in vitro-stimulated whole blood aids in the diagnosis of non-IgE-mediated gastrointestinal food allergies Hisako Yagi, Takumi Takizawa, Naoya Arakawa, Satoshi Yamada, Koichiro Sato, Yutaka Nishida, Hirokazu Arakawa Department of Pediatrics, Gunma University Graduate School of Medicine, Japan MS14-6 Serum IL-2 and IL-10 levels overshoot in acute food protein-induced enterocolitis syndrome Tamaki Nakamura1）, Hiroki Yasudo1）, Ken Fukuda1）, Fumiko Okazaki1）, Hiroyuki Wakiguchi1）, Seigo Korematsu2）, Kenji Matsumoto3）, Shouichi Ohga4）, Shunji Hasegawa1） Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan1）; Department of Pediatrics, Oita University Faculty of Medicine, Japan2）; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Japan3）; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Japan4） iiSymposium Mini Mini Symposium 15

Food allergy-Immunotherapy MS15-1 Comparison of 3-year outcomes of wheat OIT between low dose and high dose Yoko Miura1）, Ken-ichi Nagakura1）, Noriyuki Yanagida1）, Sakura Sato2）, Motohiro Ebisawa2） Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan1）; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2） MS15-2 Sustained unresponsiveness: How long should oral immunotherapy be continued? Mayu Maeda, Takanori Imai, Toshinori Nakamura, Kosei Yamashita, Toshiyuki Takagi, Yuki Okada, Taro Kamiya, Katsumi Mizuno Department of pediatrics, Showa University School of Medicine, Japan MS15-4 Establishment of sustained unresponsiveness to food allergens by oral immunotherapy is prevented by inhibition of Notch signaling Nobuhiro Nakano1）, Toshiyuki Yoneyama2）, Mutsuko Hara1）, Hiromichi Yamada2）, Kumi Izawa1）, Koichiro Uchida1）, Ayako Kaitani1）, Tomoaki Ando1）, Jiro Kitaura1）, Yoshikazu Ohtsuka2）, Toshiaki Shimizu2）, Hideoki Ogawa1）, Ko Okumura1） Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Japan1）; Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Japan2） MS15-5 Immunotherapy with hypoallergen nanoplasmid DNA vaccine in a mouse model of shrimp hypersensitivity Christine YY Wai1）, Ka Hou Chu2）, Patrick SC Leung3）, Ting Fan Leung1） Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong1）; School of Life Sciences, The Chinese University of Hong Kong, Hong Kong2）; Division of Rheumatology/Allergy, School of Medicine, University of California, USA3） MS15-6 Epicutaneous immunotherapy for severe milk allergy utilizing a novel antigen delivery device: a double-blind placebo-controlled pilot study Yu Kuwabara1,4,6）, Mizuho Nagao1,4）, Sayami Ito2）, Naoki Okada2）, Mio Saito3）, Ying-Shu Quan3）, Fumio Kamiyama3）, Komei Ito4）, Motohiro Ebisawa4,5）, Yuichi Adachi4）, Makoto Kameda4）, Shigemi Yoshihara4）, Akira Hoshioka4）, Mizue Tsukui4）, Yusei Oshima4）, Hirokazu Arakawa4）, Naoki Shimojo4）, Naoka Itoh4）, Takao Fujisawa1,4） National Hospital Organization Mie National Hospital, Japan1）; Project for Vaccine and Immune Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Japan2）; CosMED Pharmaceutical Co. Ltd, Japan3）; AMED Ebisawa reserach group, Japan4）; National Hospital Organization Sagamihara National Hospital, Japan5）; Department of Pediatrics, Ehime University Graduate School of Medicine, Japan6）

Mini Symposium 16

Immunotherapy MS16-1 Disease modifying effects of Japanese cedar pollen sublingual immunotherapy tablets in patients with Japanese cedar pollinosis: A randomized, double-blind, placebo-controlled study Syuji Yonekura1）, Minoru Gotoh2）, Satoko Kobayashi3）, Yuriko Maekawa3）, Kimihiro Okubo2）, Yoshitaka Okamoto1,4） Department of Otorhinolaryngology, Head and Neck Surgery, Chiba University Hospital, Japan1）; Department of Otorhinolaryngology and Head and Neck Surgery, Nippon Medical School Hospital, Japan2）; Torii Pharmaceutical Co., Ltd., Japan3）; Chiba Rosai Hospital, Japan4） 484

MS16-2 Role of whole saliva in the efficacy of sublingual immunotherapy in seasonal allergic rhinitis Takenori Haruna1,2）, Mitsuhiro Okano3）, Tazuko Fujiwara2）, Shin Kariya2）, Atsushi Yuta4）, Takaya Higaki2）, Pengfei Zhao2）, Yukiko Ogawa4）, Aiko Oka3）, Teruhiro Ogawa1）, Tadahiko Saiki1）, Kazunori Nishizaki2） Department of Otorhinolaryngology, Himeji St Mary’s Hospital, Japan1）; Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan2）; Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Japan3）; Yuta Clinic, Japan4） MS16-3 Pronounced IgE- and T-cell cross-reactivity towards birch homologous tree pollen allergens confirmed by changes in IgE and IgG4 antibody responses during SQ tree SLIT-tablet treatment Peter A Würtzen1）, Pernille M Grønager1）, Gitte Lund1）, Katsuyo Ohashi-Doi2）, Shashank Gupta1）, Peter S Andersen1）, Henrik Ipsen1） ALK, Denmark1）; Torii Pharmaceutical Co., Ltd., Japan2） MS16-4 An inhibitory factor for mast cell degranulation induced by sublingual immunotherapy Osamu Kaminuma1,3,5）, Minoru Gotoh1,2）, Noriko Kitamura1）, Mayumi Shindo4）, Nobumasa Watanabe1）, Mayumi Saeki1）, Tomoe Nishimura1）, Akio Mori5）, Soichi Nemoto6）, Hideki Tatsumi6）, Kimihiro Okubo1,2）, Takachika Hiroi1） Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Japan1）; Department of Otorhinolaryngology, Nippon Medical School, Japan2）; Department of Disease Model, Hiroshima University, Japan3）; Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science, Japan4）; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan5）; Department of Obstetrics and Gynecology, National Hospital Organization Sagamihara National Hospital, Japan6） MS16-5 The immunological annexin-checkpoint-system for the treatment of allergy Maria A Baar1,2）, Asa Hidmark1）, Fatmire Bujupi-Osmani1）, Raman Agrawal3）, Kevin Bode1）, Peter H Krammer1）, Heiko Weyd1） Division of Immunogenetics, German Cancer Research Center, Germany1）; Faculty of Biosciences, Ruprecht Karls University Heidelberg, Germany2）; Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, Ruprecht Karls University Heidelberg, Germany3） MS16-6 Efficacy and safety analysis of standardized dust mite specific subcutaneous immunotherapy Lan Chen Shenzhen Hospital of Southern Medical University, China

Mini Symposium 17

Mechanisms of asthma MS17-1 Cellular and molecular crosstalk in the development of allergic airway inflammation Hiroki Furuya1）, Arifumi Iwata1）, Eiryo Kawakami2）, Takashi Kumagai1）, Osamu Ohara3）, Hiroshi Nakajima1） Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Japan1）; Department of Artificial intelligence medicine, Graduate School of Medicine, Chiba University, Japan2）; Kazusa DNA Research Institute, Japan3） MS17-2 TNFSF14 (LIGHT) induces sustained airway smooth muscle contractility via non-canonical NFκB signaling Haruka Miki1）, William B Kiosses2）, Rana Herro1）, Michael Croft1,3） Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, USA1）; Core Microscopy, La Jolla Institute for Immunology, USA2）; Department of Medicine, University of California San Diego, USA3） iiSymposium Mini MS17-3 TLR9IL-2 axis enhances Th2 activation and exacerbates HDM-induced allergic asthma by preventing IL-17A hyperproduction Yusuke Murakami1）, Takashi Ishii1）, Hiroki Nunokawa1）, Keigo Kurata2）, Tomoya Narita1）, Naomi Yamashita1） Department of Pharmaceutical Sciences, Musashino University, Japan1）; Institute of Tokyo Environmental Allergy, Inc., Japan2） MS17-4 Microbiome contribute to increase pulmonary response to ozone in obese mice Hiroki Tashiro1,2）, Koichiro Takahashi1）, Hironori Sadanatsu1）, Yuki Kurihara1）, Naoko Aragane1）, Lynn Bry3）, Stephanie Ann Shore2） Department of Respiratory Medicine, Saga University Hospital, Japan1）; Department of Enviromental Health, Harvard School of Public Health, USA2）; Massachusetts Host Microbiome Center, and Women’s Hospital, USA3） MS17-5 STING promotes IgE production in HDM-induced allergic asthma Hiroki Nunokawa1,2）, Yusuke Murakami1）, Tomoya Narita1）, Takashi Ishii1）, Haruyuki Ishii2）, Hajime Takizawa2）, Naomi Yamashita1） Department of Pharmacotherapy, Research Institute of Pharmaceutical Sciences, Musashino University, Japan1）; Department of Respiratory Medicine, Kyorin University School of Medicine, Japan2） MS17-6 Enhanced airway hyperresponsiveness in a mouse model of asthma with A (H1N1) pdm09 infection Hiroki Yasudo1）, Taira Ariyoshi1）, Yasufumi Sakata1）, Tamaki Nakamura1）, Takeshi Matsushige1）, Hideki Hasegawa2）, Noriko Nakajima2）, Akira Ainai2）, Atsunori Oga3）, Hiroshi Itoh3）, Komei Shirabe4）, Shoichi Toda4）, Ryo Atsuta5）, Shouichi Ohga6）, Shunji Hasegawa1） Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan1）; Department of Pathology, National Institute of Infectious Diseases, Japan2）; Department of Molecular Pathology, Yamaguchi University Graduate School of Medicine, Japan3）; Yamaguchi Prefectural Institute of Public Health and Environment, Japan4）; Akihabara Atsuta Clinic, Japan5）; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Japan6）

Mini Symposium 18

Novel aspect of development and treatment of allergic diseases MS18-1 Analysis of novel hygiene hypothesis model using spontaneous atopic dermatitis mice Yukihiko Kato1）, Chiho Yanai1）, Ryo Muko2）, Yosuke Amagai2）, Yoshihiro Umebayashi1）, Hiroshi Matsuda2）, Akane Tanaka2） Department of Dermatology, Tokyo Medical University, Hachioji Medical Center, Japan1）; Division of animal life science, Comparative animal science, Tokyo University of Agriculture and Technology, Japan2） MS18-2 Topical administration of particulate pollens induces IL-33- and mast cell-dependent eosinophilic conjunctivitis in mice Tomoaki Ando1）, Saaya Fukase1,2,3）, Moe Matsuzawa1,2,3）, Ayako Kaitani1）, Kumi Izawa1）, Ko Okumura1）, Akira Murakami2）, Nobuyuki Ebihara2,3）, Jiro Kitaura1） Atopy Research Center, Juntendo University Graduate School of Medicine, Japan1）; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Japan2）; Department of Ophthalmology, Juntendo University Urayasu Hospital, Japan3） MS18-3 Glucagon-like peptide 1 receptor agonist treatment inhibits allergic innate immunity-induced eosinophilic and neutrophilic inflammation in a polygenic obese mouse model Shinji Toki1）, Richard L Printz2）, Dawn C Newcomb1,3）, Katherine N Cahill1）, Kevin D Niswender1,2）, R Stokes Peebles Jr.1,3） Department of Medicine, Vanderbilt University Medical Center, USA1）; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, USA2）; Department of Pathology, Microbiology and Immunology,, Vanderbilt University Medical Center, USA3） 485

MS18-4 The non-antibiotic macrolide EM900 attenuates HDM-induced airway inflammation in obese asthma model Hironori Sadamatsu1）, Koichiro Takahashi1）, Hiroki Tashiro1）, Yuki Kurihara1）,GoKato2）, Masaru Uchida3）, Keigo Kurata5）, Yoshihiko Noguchi4）, Shinya Kimura1）, Toshiaki Sunazuka4）, Naoko Sueoka-Aragane1） Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan1）; Saga Prefectual Hospital Koseikan, Japan2）; Japan Community Healthcare Organization Saga Central Hospital, Japan3）; Kitasato Institute for Life Sciences, Kitasato University, Japan4）; Institute of Tokyo Environmental Allergy, Japan5） MS18-5 IL4R is a susceptibility locus associated with total IgE levels in Japanese population Kenshi Yamasaki1）, Kosuke Shido1）, Kaname Kojima2,3）, Matsuyuki Shirota2,4,5）, Ikuko N Motoike2）, Atsushi Hozawa2）, Soichi Ogishima2,6）, Naoko Minegishi2,6）, Kozo Tanno7）, Fumiki Katsuoka2）, Gen Tamiya2,3）, Setsuya Aiba1）, Masayuki Yamamoto2,6,8）, Kengo Kinoshita2,5,6,9） Department of Dermatology, Tohoku University Graduate School of Medicine, Japan1）; Tohoku Medical Megabank Organization, Tohoku University, Japan2）; RIKEN Center for Advanced Intelligence Project, Japan3）; Division of Interdisciplinary Medical Science, Graduate School of Medicine, Tohoku University, Japan4）; Graduate School of Information Sciences, Tohoku University, Japan5）; Advanced Research Center for Innovations in Next- Generation Medicine, Tohoku University, Japan6）; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Japan7）; Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University, Japan8）; Institute of Development, Aging and Cancer, Tohoku University, Japan9） MS18-6 Novel effect and mechanism of a steroid alkaloid derivative 02F04 on thymic stromal lymphopoietin production in PAM212 cells Yan Weng1,2）, Noriyasu Hirasawa2）, Wen Jing Wang1）, Dong Ai Wen1） Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, China1）; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan2）

Mini Symposium 19

Pediatric asthma 1 MS19-1 Comparison of allergic march with 20 year interval Takaaki Itonaga1）, Tomoyuki Asaumi1）, Makoto Nishino1）, Kyohei Takahashi1）, Ken-ichi Nagakura1）, Masamichi Iguchi2）, Kiyotake Ogura1）, Noriyuki Yanagida1）, Sakura Sato1）, Motohiro Ebisawa1） Department of Pediatrics, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan1）; Iguchi Pediatric Clinic, Japan2） MS19-2 Development of a wheeze recognition algorithm for practical implementation in children and validation in USA and Japan Chizu Habukawa1）, Takahiko Arai2）, Haruyuki Makata3）, Tomoki Nishikido4）, Morimitsu Tomikawa5）, Tokihiko Fujino6）, Tetsuharu Manabe7）, Yoshihito Ogihara8）, Kiyotaka Ohtani9）, Kenichiro Shirao10）, Kazuko Sugai11）, Katsumi Murakami12） Department of Pediatric allergy, Japan1）; Arai Pediatric Clinic, Japan2）; Makata Pediatrics & Allergy Clinic, Japan3）; Women’s and Children’s Hospital, Japan4）; Pediatrics And Allergy, Japan5）; Kokura Allergy Clinic, Japan6）; Manabe Pediatric Clinic, Japan7）; Ogihara Kids Clinic, Japan8）; Kirin Kids Allergy Clinic, Japan9）; Shirao Clinic of Pediatrics and Pediatric Allergy, Japan10）; Sugai Children’s Clinic Pediatrics/Allergy, Japan11）; Sakai Sakibana Hospital, Japan12） MS19-3 Atopic dermatitis phenotypes in children have distinctive wheezing trajectories Sungsu Jung1）, Hyung Young Kim1）, So-Yeon Lee2）, Jisun Yoon3）, Hyun-Ju Cho4）, Minji Park2）, Song-I Yang5）, Eun Lee6）, Soo-Jong Hong2） Symposium Mini Department of Pediatrics, Pusan National University Yangsan Hospital, Republic of Korea1）; Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College, Republic of Korea2）; Department of Pediatrics, Mediplex Sejong Hospital, Republic of Korea3）; Department of Pediatrics, International St Mary’s hospital, Catholic Kwandong University Hospital, Republic of Korea4）; Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Republic of Korea5）; Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Republic of Korea6） MS19-4 Association between Der p 23 and asthma in children sensitized to house dust mite Yuya Tanaka1）, Saori Omae3）, Taro Ueda2）, Tamaki Ito2）, Ikuo Okafuji2）, Katsuyo Doi3）, Satoru Tsuruta2） Department of Allergy, Kobe Children’s Hospital, Japan1）; Department of Pediatrics, Kobe City Medical Center General Hospital, Japan2）; Torii Pharamceutical Co Ltd, Japan3） MS19-5 The effect of sensitization to house dust mite on the asthma development is modified by TNF-α (rs1800629) polymorphism Eun Lee1）, So-Yeon Lee2）, Min Jee Park2）, Soo-Jong Hong2） Chonnam National University Hospital, Chonnam National University Medical School, Republic of Korea1）; Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Me, Republic of Korea2） MS19-6 Novel lipid antivirals protect against human Rhinovirus-C infection Mari Numata-Nakamura1）, Yury A Bochkov2）, Heejung Lee1）, Max A Seibold1）, Andrew Liu3）, Dennis R Voelker1） Medicine, National Jewish Health, USA1）; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, USA2）; Children’s Hospital Colorado, USA3）

Mini Symposium 20

Pediatric asthma 2 MS20-1 PM10 exposure during pregnancy increases the risk of childhood asthma modified by gender and genotype Hyo-Bin Kim1）, Hyeyeun Lim2）, Sang Rok Kim2）, Mi-Jin Kang2）, Hwan-Cheol Kim3）, So-Yeon Lee2）, Minji Park2）, Sungsu Jung4）, Jisun Yoon5）, Hyun-Ju Cho6）, Song-I Yang7）, Eunseol Kim8）, Jeongrim Lee8）, Jeom-Kyu Lee9）, Woo-Sung Chang9）, Soo-Jong Hong2） Department of Pediatrics, Inje University Sanggye Paik Hospital, Republic of Korea1）; Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Me, Republic of Korea2）; Department of Occupational and Environmental Medicine, Inha University School of Medicine, Republic of Korea3）; Department of Pediatrics, Pusan National University Yangsan Hospital, Republic of Korea4）; Department of Pediatrics, Mediplex Sejong Hospital, Republic of Korea5）; Department of Pediatrics, International St Mary’s Hospital, Catholic Kwandong University Hospital, Republic of Korea6）; Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Republic of Korea7）; Korea Institute of Child Care and Education, Republic of Korea8）; Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences Korea National Institute of Health, Korea Centers for D, Republic of Korea9） MS20-2 Prevalence and time trends of allergic disease among Japanese children: interpretation of T helper 2 biomarker levels for clinical applications Houman Goudarzi1,2）, Atsuko Araki2）, Chihiro Miyashita2）, Yu Ait Bamai2）, Sachiko Ito2）, Reiko Kishi2）, Masaharu Nishimura1）, Satoshi Konno1） Department of Respiratory Medicine, Hokkaido University, Japan1）; Center for Environmental and Health Sciences, Hokkaido University, Japan2） 486

MS20-3 Airway mechanics after withdrawal of a leukotriene receptor antagonist in children with mild-persistent asthma: double blind, randomized, cross-over study Ju Hee Kim1）, Shinhea Lee1）, Youn Ho Shin2）, Eun Kyo Ha3）, Seung Won Lee4）,MiAeKim5）, Man Yong Han1） Department of Pediatrics, CHA Bundang Hospital, Republic of Korea1）; Department of Pediatrics, CHA Gangnam Medical Center, Republic of Korea2）; Department of pediatrics, Kangnam Sacred Heart Hospital, Republic of Korea3）; Department of Data Science, Sejong University College of Software Convergence, Republic of Korea4）; Departments of Internal Medicine, CHA Bundang Medical Center, Republic of Korea5） MS20-4 Global Asthma Network (GAN): factors associated with asthma in adolescents living en Uruguaiana, Brazil Marilyn Urrutia-Pereira1）, Herberto Chong Neto2）, Pietro Nunes Rinelli1）, Laura Simon1）, Philippa Ellwood3）, Luis García-Marcos4）, Dirceu Solé5） Federal University of Pampa, Brazil1）; Federal University of Paraná, Brazil2）; University of Auckland, New Zealand3）; University of Murcia, Spain4）; Federal University of São Paulo, Brazil5） MS20-5 Pharyngeal Streptococcus pneumoniae colonization in acute exacerbations of childhood bronchial asthma is associated with shorter duration of wheezing and lower levels of serum TNF-α Yuichi Kama1,2）, Masahiko Kato1,2）, Yoshiyuki Yamada3）, Takashi Koike1）, Kazuo Suzuki1）, Mayumi Enseki1）, Hideyuki Tabata1）, Kota Hirai1,2）, Hiroyuki Mochizuki1） Department of Pediatrics, Tokai University School of Medicine, Japan1）; Department of Pediatrics, Tokai University Hachioji Hospital, Japan2）; Department of Allergy and Immunology, Gunma Children’s Medical Center, Japan3） MS20-6 Role of eosinophil and neutrophils on lung function and prognosis in children with acute asthma exacerbation Jintack Kim, Hwansoo Kim Department of Pediatrics, St Mary’s Hospital, Catholic University of Korea, Republic of Korea

Mini Symposium 21

Pollinosis MS21-1 Genome-wide association for pollen allergen sensitization using the dataset of an adult general population Wataru Morii, Emiko Noguchi Depertment of Medical Genetics, University of Tsukuba, Japan MS21-2 Effect of lactobacillus plantarum YIT 0132 on Japanese cedar pollinosis and regulatory T cells in adults Shuichi Suzuki1）, Norihiro Kubota2）, Sayaka Kakiyama2）, Kouji Miyazaki2）, Kazuki Sato1）, Naomi Harima-Mizusawa2） National Hospital Organization Shimoshizu National Hospital, Japan1）; Yakult Central Institute, Japan2） MS21-3 Latent 1, 3-β-D-glucan acts as an adjuvant for allergen-specific IgE production induced by Japanese cedar pollen exposure Takashi Kanno1）, Yoshiyuki Adachi1）, Katsuyo Ohashi-Doi2）, Hiroki Matsuhara2）, Rie Hiratsuka3）, Ken-ichi Ishibashi1）, Daisuke Yamanaka1）, Naohito Ohno1） Laboratory for Immunopharmacology of microbial products, Tokyo University of Pharmacy and Life Sciences, Japan1）; Research Laboratory, Torii Pharmaceutical Co., Ltd., Japan2）; Division of Biology, Department of Natural Science, The Jikei University School of Medicine, Japan3） MS21-4 Clinical implications of Phl p1/5 and Ole e1 sensitization in patients with positive skin prick tests to grass and olive tree pollen iiSymposium Mini Pedro Silva1,2）, Sara Nunes2） Allergy and Clinical Imunology, Grupo HPA Sade, Portugal1）; Departamento de Ciências Biomédicas, Universidade do Algarve, Portugal2） MS21-5 Relationship between body mass index and the prevalence of seasonal allergic rhinitis Yoko Osawa1）, Takahiro Tokunaga2）, Yumi Ito3）, Yukinori Kato3）, Taiyo Morikawa1）, Keisuka Koyama3）, Rikako Gozawa3）, Masanori Kidoguchi3）, Norihiko Narita3）, Shigeharu Fujieda3） Department of Otorhinolaryngology, Fukui Red Cross Hospital, Japan1）; Department of Otorhinolaryngology, Shinseikai Toyama Hospital, Japan2）; Division of Otorhinolaryngology - Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University, Japan3） MS21-6 PUF60, a possible drug discovery target for the therapy of pollinosis by suppressing nuclear factor of activated T-cells signaling Yoshiaki Kitamura1）, Hiroyuki Mizuguchi2）, Hiroyuki Fukui1）, Noriaki Takeda1） Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan1）; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Japan2）

Mini Symposium 22

Regulation of immune cells MS22-1 Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation Kensuke Miyake1）, Junya Ito1）, Kazufusa Takahashi1）, Soichiro Yoshikawa2）, Yoshinori Yamanishi1）, Hajime Karasuyama1） Inflammation, Infection and Immunity Laboratory, Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Japan1）; Department of Cell Physiology, Okayama University, Japan2） MS22-2 Differential lipid recognition by mouse versus human CD300f, inhibiting IgE- and mast cell-dependent anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Akie Maehara, Enzhi Yin, Moe Matsuzawa, Taiki Ando, Takuma Ide, Yoko Okamoto, Saaya Fukase, Mayuki Kojima, Anna Kamei, Hexing Wang, Ko Okumura, Jiro Kitaura Atopy (Allergy) Research Center, Juntendo University School of Medicine, Japan

MS22-3 Mast cell derived PGD2 reduces honeybee venom absorption in mice Tatsuro Nakamura, Yuki Fujiwara, Takahisa Murata Department of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan MS22-4 A monoclonal antibody to Siglec-8 inhibits IgE/FcεRI mast cell activation by suppressing downstream intracellular signaling through ITIM Induction Wouter Korver, Simon Gebremeskel, Alan Wong, Bradford A Youngblood Allakos Inc, USA 487

MS22-5 miR103a-3p in extracellular vesicles derived from human mast cells following aggregation of FcεRI enhances IL-5 production from IL- 33-stimulated type2 innate lymphoid cells via PRMT5 Shota Toyoshima1,2,3）, Tomomi Sakamoto-Sasaki1,2）, Yusuke Kurosawa2,3）, Koremasa Hayama2,4）, Akira Matsuda5）, Yasuo Watanabe5）, Tadashi Terui2,4）, Yasuhiro Gon2,3）, Kenji Matsumoto6）, Yoshimichi Okayama1,2） Allergy and Immunology Project Team, Center for Institutional Research and Medical Education, Nihon University School of Medicine, Japan1）; Center for Allergy, Nihon University School of Medicine, Japan2）; Department of Respiratory Medicin, Nihon University School of Medicine, Japan3）; Department of Dermatology, Nihon University School of Medicine, Japan4）; Department of Ophthalmology, Juntendo University, Japan5）; Department of Allergy & Immunology, National Research Institute for Child Health and Development, Japan6） MS22-6 P2Y6 receptor signal by the UDP stimulation increases cAMP and IP1 in human basophils Manabu Nakano1,2）, Hideki Takami1）, Kyoko Ito1）, Koichi Ito1,2） Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, Japan1）; Research Center for Biomedical Sciences, Hirosaki University Graduate School of Health Sciences, Japan2）

Mini Symposium 23

Rhinosinusitis 1 MS23-1 Local steroid insensitivity in refractory eosinophilic airway inflammation Yoshiki Kobayashi1,2）, Akira Kanda1,2）, Yasutaka Yun1）, Dan Van Bui1）, Mikiya Asako1,2）, Hiroshi Iwai1） Department of Otorhinolaryngology, Kansai Medical University Hospital, Japan1）; Allergic Center, Kansai Medical University Hospital, Japan2） MS23-2 The role of semaphorins in allergic diseases and their therapeutic implications in eosinophilic chronic rhinosinusitis Masayuki Nishide1）, Takeshi Tsuda2）, Atsushi Kumanogoh1） Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Japan1）; Department of Otorhinolaryngology Head and Neck Surgery, Osaka University Graduate School of Medicine, Japan2） MS23-3 Comparison of clinical characteristics of the nasal manifestations of Eosinophilic Granulomatosis with Polyangiitis (EGPA) and Eosinophilic Chronic Rhinosinusitis (ECRS) Akira Nakazono, Masanobu Suzuki, Shogo Kimura, Aya Honma, Yuji Nakamaru, Akihiro Homma Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan MS23-4 Anti-inflammatory effects of 17, 18-epoxyeicosatetraenoic acid and its metabolite on IL-33-induced innate eosinophilic inflammation in upper airway Ichiro Tojima, Shiori Hara, Keigo Nakamura, Sayuri Yamamoto, Hiroyuki Arai, Hideaki Kouzaki, Shino Shimizu, Takeshi Shimizu Department of Otorhinolaryngology, Shiga University of Medical Science, Japan MS23-5 A nomogram combining objective inflammatory biomarkers for prediction of recurrence of postoperative chronic rhinosinusitis with nasal polyps Ming Zheng, Xiangdong Wang, Kun Du, Luo Zhang Department of Otorhinolaryngology- Head and Neck Surgery, Beijing Tongren Hospital, China MS23-6 Association between the NOS2 pentanucleotide repeat polymorphism and risk of postoperative recurrence of chronic rhinosinusitis with nasal polyps in a Japanese population Symposium Mini Masanori Kidoguchi1,2）, Emiko Noguchi2）, Shigeharu Fujieda1） Division of Otorhinolaryngology and Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Japan1）; Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Japan2）

Mini Symposium 24

Rhinosinusitis 2 MS24-1 The role of DUOX1 in the productions of epithelial-derived cytokines in eosinophilic chronic rhinosinusitis Hideaki Kouzaki, Sayuri Yamamoto, Hiroyuki Arai, Takeshi Shimizu Department of otorhinolaryngplogy, Shiga University of Medical Science, Japan MS24-2 TGF-β1-induced HSP47 regulates extracellular matrix accumulation via Smad2/3 signaling pathways in nasal fibroblasts Heung-Man Lee Department of Otorhinolaryngology-Head and Neck Surgery, Guro Hospital, Korea University, College of Medicine, Republic of Korea MS24-3 More severe ECRS patients produce more TSLP in the paranasal sinus mucosa Akiko Inoue1）, Yuriko Tanaka2）, Motonari Kondo2）, Hidehito Matsui1）, Takara Nakazawa1）, Shinya Ohira1）, Hiroshi Osafune1）, Kota Wada1） Department of Otorhinolaryngology, Toho University Omori Medical Center, Japan1）; Department of Molecular Immunology, Toho University School of Medicine, Japan2） MS24-4 Relationships between increased serum leptin levels and eosinophilic chronic rhinosinusitis Yoshimasa Imoto, Tetsuji Takabayashi, Yukinori Kato, Masafumi Sakashita, Shigeharu Fujieda Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Japan MS24-5 Pathophysiology of eosinophilic chronic rhinosinusitis characterized by multi-omics analysis Tomohisa Iinuma, Syuji Yonekura, Junya Kurita, Toyoyuki Hanazawa Department of Otorhinolaryngology, Head and Neck Surgery, Chiba University Graduate School of Medicine, Japan MS24-6 Metabolomics of lipid mediator in nasal polyps with eosinophilic chronic rhinosinusitis by Liquid Chromatography Mass Spectrometory (LC-MS) Masafumi Sakashita, Yoshimasa Imoto, Masanori Kidoguchi, Tetsuji Takabayashi, Yukinori Kato, Toshiki Tsutsumiuchi, Kanako Yoshida, Naoto Adachi, Masayuki Okamoto, Norihiko Narita, Shigeharu Fujieda Department of Otorhinolaryngology, University of Fukui, Japan 488

Mini Symposium 25

Treatment for adult asthma 1 MS25-1 Evaluation of expiratory capacity with severe asthma following bronchial thermoplasty Satoru Ishii, Motoyasu Iikura, Akinari Tsukada, Chie Morita, Takashi Katsuno, Junko Hirashima, Manabu Suzuki, Shinyu Izumi, Masayuki Hojo, Haruhito Sugiyama Department of Respirology Medicine, National Center for Global Health and Medicine, Japan MS25-2 Evaluation of biomarkers among patients undergoing bronchial thermoplasty Hiroyuki Tashimo1）, Maho Suzukawa1）, Sumie Nakamura2）, Masahiro Ohgiya2）, Masahiro Shimada2）, Osamu Narumoto2）, Nobuharu Ohshima2）, Ken Ohta3） Center for Asthma and Allergy, Tokyo National Hospital, Japan1）; Center for Pulmonary Diseases, Tokyo National Hospital, Japan2）; JATA Fukujuji Hospital, Japan3） MS25-3 Whole blood gene expression profiling in severe asthma patients treated with benralizumab Masayuki Nakajima1）, Masashi Matsuyama1）, Mio Kawaguchi1）, Haruna Kitazawa1）, Naoki Arai3）, Rie Shigemasa1）, Kazufumi Yoshida1）, Kentaro Hyodo3）, Hideyasu Yamada2）, Hironori Masuko1）, Takumi Kiwamoto1）, Yuko Morishima1）, Yukio Ishii1）, Tohru Sakamoto1）, Takefumi Saito3）, Nobuyuki Hizawa1） Department of pulmonary medicine, University of Tsukuba Hospital, Japan1）; Department of respiratory medicine, Hitachinaka General Hospital, Japan2）; National Hospital Organization Ibarakihigashi National Hospital, Japan3） MS25-4 The effectiveness of mepolizumab for peripheral neurological symptoms in eosinophilic granulomatosis with polyangiitis Yuto Nakamura1）, Yuma Fukutomi1）, Yuichiro Kawasaki1）, Norihiro Fujita1）, Maki Iwata1）, Kisako Nagayama1）, Koichi Yano1）, Yuto Hamada1）, Kentaro Watai1）, Kai Ryu1）, Hiroaki Hayashi1）, Yosuke Kamide1）, Akio Mori1）, Masami Taniguchi1,2）, Kiyoshi Sekiya1） Department of Respiratory Medicine and Allergy, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Center for Immunology and Allergology, Shonan Kamakura General Hospital, Japan2） MS25-5 Changes of lower airway mucus plugs after administration of biologics and its clinical impacts in severe asthma Yusuke Hayashi, Satoshi Marumo, Yujiro Kikuchi, Tomoki Maetani, Atsushi Matsunashi, Michihiro Uyama, Yusuke Shiraishi, Takamitsu Imoto, Takamasa Kitajima, Daiki Inoue, Motonari Fukui Department of Respirology, Kitano Hospital, Japan MS25-6 Effect of dupilumab in asthma patients with serologic evidence of allergic bronchopulmonary aspergillosis Kazuhiko Arima1）, Hiroyuki Fujita1）, Masanori Miyata1）, Jonathan Corren2）, Lawrence Sher3）, Nadia Daizadeh4）, Benjamin Ortiz5）, Michel Djandji4）, Nikhil Amin5） Sanofi K.K., Japan1）; David Geffen School of Medicine, USA2）; Peninsula Research Associates, USA3）; Sanofi U.S., USA4）; Regeneron Pharmaceuticals, Inc., USA5）

Mini Symposium 26

iiSymposium Mini Treatment for adult asthma 2 MS26-1 Efficacy of probiotics administration in patients with uncontrolled asthma: a randomized placebo controlled trial Sasipa Sangkanjanavanich1）, Chirawat Chiewchalermsri1）, Atik Sangasapaviliya1）, Panitan Pradubpongsa1）, Tadech Boonpiyathad1）, Wat Mitthamsiri1）, Nattapon Jaisupa2）, Sarawut Jindarat2） Department of Medicine, Phramongkutklao Hospital, Thailand1）; Department of Pharmacology, Phramongkutklao College of Medicine, Thailand2） MS26-2 Can we predict response of refractory asthmatic cough to Tiotropium? :a randomized prospective study Kensuke Fukumitsu, Yoshihiro Kanemitsu, Ryota Kurokawa, Norihisa Takeda, Hirono Nishiyama, Yoshitsugu Inoue, Jenifer Yap, Satoshi Fukuda, Takehiro Uemura, Tomoko Tajiri, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Japan MS26-3 Efficacy of single inhaler, once-daily indacaterol/glycopyrronium/mometasone furoate in inadequately controlled asthma: a post-hoc Asian population analysis of the IRIDIUM study Hironori Sagara1）, Nathalie Barbier2）, Tsuyoshi Ishii3）, Hajime Yoshisue3）, Ivan Nikolaev2）, Ioannis Kottakis2）, Yasuhiro Gon4） Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, Japan1）; Global Medical Affairs Novartis Pharma AG, Switzerland2）; Novartis Pharma K.K., Japan3）; Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Japan4） MS26-4 Long-term safety of once-daily single inhaler triple therapy with fluticasone furoate/umeclidinium/vilanterol in Japanese patients with asthma: a Phase III open-label study Soichiro Hozawa1）, Hiroyuki Ohbayashi2）, Andrew Fowler3）, Laurie Lee4）, Takashi Nakayama5） Hiroshima Allergy and Respiratory Clinic, Japan1）; Tohno Chuo Clinic, Japan2）; GlaxoSmithKline, UK3）; GlaxoSmithKline, USA4）; GlaxoSmithKline K.K., Japan5） MS26-5 Clinical features of asthma patients with high-intensity treatment based on questionnaire survey in Niigata, Japan Yosuke Kimura1）, Takashi Hasegawa2）, Yui Murai1）, Natsumi Sakai1）, Akira Saito1）, Mio Toyama1）, Keisuke Tsukioka1）, Masachika Hayashi1）, Toshiyuki Koya1）, Ei-ichi Suzuki2）, Toshiaki Kikuchi1） Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Japan1）; Department of General Medicine, Niigata University Medical and Dental Hospital, Japan2） MS26-6 Adjunctive vitamin d2 supplement improved clinical response and lung function in patients with allergen-specific immunotherapy; a randomized, double-blinded, placebo-controlled trial Chirawat Chiewchalermsri1）, Tadech Boonpiyathad1）, Sasipa Sangkangjanavanich1）, Atik Sangasapaviliya1）, Panitan Pradubpongsa1）, Wat Mitthamsiri1）, Sarawut Jindarat2）, Nattapon Jaisupa2） Allergy and clinical immunology, Department of Medicine, Phramongkutklao Hospital, Thailand1）; Department of Pharmacology, Phramongkutklao College of Medicine, Thailand2） 489

Poster Session

Poster Session 1

Adult airway diseases PE1-1 Efficacy and safety of levamisole as an immunodulator in the treatment of drug resistant tuberculosis Nikhil Sarangdhar1）, Kishor C Mohanty1,2） Department of TB & Respiratory diseases, K. J. Somaiya Medical College & Hospital, India1）; Department of TB & Chest Diseases, Grant Medical College & Sir JJ Group of Hospitals, India2） PE1-2 Clinical usefulness of serum and sputum YKL-40 in the management of asthma, ACO and COPD Yasuhito Suzuki, Junpei Saito, Mami Rikimaru, Manabu Uematsu, Atsuro Fukuhara, Takefumi Nikaido, Naoko Fukuhara, Yoshinori Tanino, Yoko Shibata Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan PE1-3 Exacerbation clusters demonstrate asthma and Chronic Obstructive Pulmonary Disease (COPD) overlap with distinct phenotypes Kentaro Hyodo1,3）, Hironori Masuko1）, Hisayuki Oshima1）, Rie Shigemasa1）, Haruna Kitazawa1）, Jun Kanazawa3）, Hiroaki Iijima2）, Takahide Kodama4）, Akihiro Nomura5）, Katsunori Kagohashi1）, Hiroaki Sato1）, Takefumi Saito3）, Tohru Sakamoto1）, Nobuyuki Hizawa1） Department of Pulmonary Medicine (Majors of Medical Sciences, Graduate School of Comprehensive Human Sciences), University of Tsukuba, Japan1）; Tsukuba Medical Center, Japan2）; National Hospital Organization Ibarakihigashi National Hospital, Japan3）; Ryugasaki Saiseikai Hospital, Japan4）; Ibaraki Seinan Medical Center Hospital, Japan5） PE1-4 Anti-allergy medication utilization in patients with chronic cough Xiao Luo1）, Wei Shao5）, Zuoyi Zhang5）, Zhi Han2,5）, Vasu Chandrasekaran3）, Vladimir Turzhitsky3）, Vishal Bali3）, Keisuke Tobe3）, Machiko Abe3）, Anna Roberts2）, Megan Metzger2）, Jarod Baker2）, Carmen La Rosa3）, Jessica Weaver3）, Paul Dexter2,4,5）, Kun Huang2,5） School of Engineering and Technology, Purdue University, USA1）; Regenstrief Institute, Inc., USA2）; Center for Observational and Real-World Evidence, Merck & Co., Inc., USA3）; Eskenazi Health, USA4）; School of Medicine, Indiana University, USA5） PE1-5 Burden of persistent chronic cough in adults in a large managed care organization Deshaun Parris1）, Robert Zeiger1）, Michael Schatz1）, Benjamin Hong2）, Fagan Xie2）, Vishal Bali1）, Jessica Weaver1）, Jonathan Schelfhout1）, Wansu Chen2）, Keisuke Tobe1） Center for Observational and Real-World Evidence (CORE), Merck & Co. Inc., USA1）; Departments of Allergy and Research and Evaluation, Kaiser Permanente Southern California (KPSC), USA2） PE1-6 Degree of skin moisture in allergic diseases varies according to complication of airway diseases Shintaro Suzuki, Kuniaki Hirai, Yoshito Miyata, Megumi Jinno, Hideki Inoue, Shin Ota, Tetsuya Homma, Akihiko Tanaka, Hironori Sagara Division of Respiratory Medicine and Allergology, Department of Internal Medicine, School of Medicine, Showa University, Japan PE1-7 Baseline characteristics from phase 3, randomized controlled trials (COUGH-1 and COUGH-2) of gefapixant, a P2X3 receptor antagonist, in refractory or unexplained chronic cough David Muccino1）, Masashi Kikuchi2）, Alyn H Morice3）, Surinder S Birring4）, Lorcan McGarvey5）, Peter V Dicpinigaitis6）, Ian D Pavord7）, Carmen La Rosa1）, Christopher Assaid1）, Jaclyn A Smith8） Merck & Co., Inc., USA1）; MSD K.K., Japan2）; Hull York Medical School, UK3）; Division of Asthma, Allergy and Lung Biology, King’s College London, UK4）; Centre for Experimental Medicine, Queen’s University Belfast, UK5）; Albert Einstein College of Medicine and Montefiore Medical Center, UK6）; Oxford NIHR Respiratory BRC, Nuffield Department of Medicine, University of Oxford, UK7）; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, UK8） PE1-8 Allergen avoidance clinical trial: correlation of symptom scores between 4 and 6 point scoring systems Todor A Popov1）, Grigoriy Garyuk2）, Igor Kaydashev3）, Svitlana Kharkivska4）, Yasuo Ohashi5）, Kimihiro Okubo6） Department of Occupational Disease, University Hospital Sv. Ivan Rilskipational, Bulgaria1）; Private Enterprise “Garyuk”, Ukraine2）; 1st City Clinical Hospital of Poltava City Council, Ukraine3）; Medical Center “Family Health”, Ukraine4）; Department of Integrated Science and Engineering for otrSession Poster Sustainable Society, Chuo University, Japan5）; Department of Otorhinolaryngology, Nippon Medical School, Japan6） PE1-9 Comparison of diffusion capacity and bronchodilator responsiveness testing in Vietnamese patients with persistent airway obstruction Tai Q Tran, Lan TT Le Department of Respiratory Functional Exploration, Viet Nam PE1-10 Role of reactive persulfides in influenza A virus-induced oxidative stress Tomohiro Ichikawa1）, Katsuya Takita1）, Hisatoshi Sugiura1）, Tadahisa Numakura1）, Takaaki Akaike2）, Masakazu Ichinose1） Department of Respiarotry Medicine, Tohoku University, Japan1）; Department of Environment Medicine and Molecular Toxicology, Tohoku University, Japan2） PE1-11 Evaluation of mucus plugs and bronchial wall thickening on three-dimensional computed tomography in patients with unexplained chronic cough whose sputum yielded filamentous basidiomycetes Haruhiko Ogawa1）, Kenichiro Okumura2）, Yuichi Yoshie2）, Takahiro Nadamura3）, Kazuya Tone4）, Noriyuki Ohkura5） Department of Environmental and Preventive Medicine, Kanazawa University, Japan1）; Department of radiology, Kanazawa University Graduate School of Medical Sciences, Japan2）; Radiology Department, Ishikawa-ken Saiseikai Kanazawa Hospital, Japan3）; Division of Respiratory Medicine, Jikei University School of Medicine, Japan4）; Respiratory Medicine, Kanazawa University Hospital, Japan5） PE1-12 Blood eosinophils at the stable period are a biomarker of frequent exacerbation for Japanese patients with COPD Yuki Kurihara, Hiroki Tashiro, Koichiro Takahashi, Hironori Sadamatsu, Tetsuro Haraguchi, Chiho Nakashima, Tomomi Nakamura, Naoko Aragane Department of Respiratory Medicine, Saga University Hospital, Japan PE1-13 The disease burden and quality of life of chronic cough patients in Japan Takekazu Kubo1）, Keisuke Tobe2）, Kotoba Okuyama1）, Masashi Kikuchi3）, Chen Yirong5）, Schelfhout Jonathan4）, Machiko Abe2）, Shigeru Tokita1） Medical Affairs, MSD K.K., Japan1）; Market Access, MSD K.K., Japan2）; Clinical Research, Japan Development, MSD K.K., Japan3）; Outcomes Research, Merck & Co., Inc., United States of America4）; Health Division, Kantar, Singapore5） PE1-14 Roles of sensitization to staphylococcal enterotoxin in patients with bronchiectasis Chie Morimoto, Hisako Matsumoto, Tsuyoshi Oguma, Susumu Sato, Isao Ito, Mariko Kogo, Natsuko Nomura, Noriyuki Tashima, Hironobu Sunadome, Toyohiro Hirai Department of Respiratory Medicine, Graduate School of Medicine Kyoto University, Japan 490

PE1-15 dsRNA and staphylococcal enterotoxin B induces opposite inflammatory reactivity in epithelial cell Jun-Pyo Choi1）, Kyung-Min Ahn2）, Purevsuren Losol1,3）, Yong Hyun Kim1,2）, Sae-Hoon Kim1,2,3）, Sang-Heon Cho2）, Yoon-Seok Chang1,2,3） Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Republic of Korea1）; Department of Internal Medicine, Seoul National University College of Medicine, Republic of Korea2）; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Council, Republic of Korea3） PE1-16 THP-1 derived macrophage shows different responses to polyI:C and staphylococcal enterotoxin Jun-Pyo Choi1）, Purevsuren Losol1,2）, Yong Hyun Kim1,3）, Sae-Hoon Kim1,2,3）, Sang-Heon Cho2,3）, Yoon-Seok Chang1,2,3） Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Republic of Korea1）; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Council, Republic of Korea2）; Department of Internal Medicine, Seoul National University College of Medicine, Republic of Korea3） PE1-17 Complication of malignancy in patients with allergic bronchopulmonary aspergillosis Hiroki Kawabata, Kanako Hara, Yosuke Chiba, Kazuhiro Yatera Department of Respiratory Medicine, The University of Occupational and Environmental Health, Japan PE1-18 Investigation of the number of oral bacteria and the conditions of asthma, COPD, and ACO Toshiya Inui1）, Yukiko Abe1）, Tatsuya Shirai1）, Kouzo Suhara1）, Maya Tsuchiya1）, Takayasu Watanabe1）, Mitsuru Sada1）, Atsuto Mouri1）, Shinkichi Iwanari2）, Mitsuhiro Kamimura1） Pulmonology Department, National Hospital Organization Disaster Medical Center, Japan1）; Department of Oral and Maxillofacial Surgery, National Hospital Organization Disaster Medical Center, Japan2） PE1-19 Anti-Aspergillus fumigatus response in stable patients with bronchiectasis Kateryna Gashynova, Kseniia Suska, Valeriia Dmytrychenko Department of Occupational Diseases and Clinical Immunology; State Institution “Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine”, Ukraine

Poster Session 2

Adult asthma 1 PE2-1 Clinical usefulness of fractional exhaled nitric oxide measurement for diagnosing prolonged cough in daily practice Masaki Hanibuchi, Atsuro Saijo, Atsushi Mitsuhashi Department of Respiratory Medicine, Shikoku Central Hospital of the Mutual aid Association of Public School teachers, Japan PE2-2 Analysis of the frequency and interest of tweet including “asthma” and “attack” in Japanese twitter users Tomomi Ichikawa1）, Takahiro Hirai1）, Zenta Seto2）, Akihiro Moriyama1）, Seisuke Okazawa2） Toyama Red Cross Hospital, Japan1）; University of Toyama, Japan2） PE2-3 The characteristics of refractory asthma who required admission for asthma exacerbation Tomoya Harada, Ryohei Kato, Miki Takata, Ryota Okazaki, Akira Yamasaki Department of Respiratory Medicine and Rheumatology, Tottori University Hospital, Japan PE2-4 Analysis of elderly asthma in Japan using NHOM-asthma data Maho Suzukawa1）, Hiroya Hashimoto2）, Hiroyuki Tashimo1）, Yoshitaka Oyamada3）, Mari Miki4）, Mitsumasa Ogasawara5）, Yoshikazu Inoue6）, Akiko Saito2）, Ken Ohta1,7） Clinical Research Center, National Hospital Organization Tokyo National Hospital, Japan1）; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Japan2）; Department of Pulmonary Medicine, National Tokyo Medical Center, Jordan3）; Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan4）; Department of Respiratory Medicine, National Hospital Organization Osaka National Hospital, Japan5）; Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan6）; Anti-Tuberculosis Association, Fukujuji Hospital, Japan7） PE2-5 Complication rates of sleep apnea syndrome in complication rates of sleep apnea syndrome in bronchial asthma - usefulness of ESS - Naoto Watanabe1,2）, Sohei Makino2）, Yoichi Nakamura1） 1） otrSession Poster Medical Center for Allergic and Immune Disease Yokohama City Minato Red Cross Hospital, Japan ; Tokyo Allergy and Respiratory Disease Institute, Japan2） PE2-6 Impact of coexisting COPD on mortality in patients with corticosteroid-dependent asthma Sang-Heon Kim, Joon Kyung Kim, Jee Yea Choi, Sung Jun Chung, Hyun Lee, Dong Won Park, Jang Won Sohn, Ho Joo Yoon Department of Internal Medicine, Hanyang University College of Medicine, Republic of Korea PE2-7 Decline of lung function in adults with a history of childhood asthma Shinichiro Miura1）, Hiroshi Iwamoto1）, Keitaro Omori2）, Kakuhiro Yamaguchi1）, Shinjiro Sakamoto1）, Yasushi Horimasu1）, Takeshi Masuda1）, Shintaro Miyamoto1）, Taku Nakashima1）, Kazunori Fujitaka1）, Hironobu Hamada1）, Akihito Yokoyama3）, Noboru Hattori1） Department of Molecular and Internal Medicine, Institute of Biomedical & Health Sciences, Hiroshima University, Japan1）; Department of Infectious Diseases, Hiroshima University, Japan2）; Department of Hematology and Respiratory Medicine, Kochi University, Japan3） PE2-8 Variability in airway responsiveness assessed by the astograph method Mari Miki, Kiyoharu Fukushima, Yuji Yamamoto, Takanori Matsuki, Yohei Oshitani, Hiroyuki Kagawa, Kazuyuki Tsujino, Keisuke Miki, Hiroshi Kida Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan PE2-9 Utility of R5-20 of MostGraph for outpatients of adult asthma in a clinic Kan Kato1,2,3）, Hiroshi Tanaka3） Department of Internal Medicine, Tokyo Kensei Hospital, Japan1）; Department of Internal Medicine, Ooizumi Health Cooperative Hospital, Japan2）; Sapporo Cough Asthma and Allergy Center, Japan3） PE2-10 “Recurrent episodes of prolonged cough” is a useful medical history to distinguish between Post-Infectious Cough (PIC) and Cough Variant Asthma (CVA) for diagnosis Masaaki Mikami Hosshoji Internal Clinic, Japan 491

PE2-11 Exercise-Induced Bronchoconstriction (EIB) confirmed by arm ergometry exercise with exhaled gas analyses in respiratory diseases Etsuo Fujita1）, Ryosuke Horitani2）, Tatsuya Aoki2）, Tadayuki Hashimoto2）, Kahoru Miyata3）, Tomomi Nakao3）, Mito Hayashi4）, Hironobu Hoshiya5）, Katsuhiro Yamamoto5）, Kyuya Gose6）, Yuji Tohda6）, Kousuke Shimada7） Department of Respiratory Medicine, Hashimoto Municipal Hospital, Japan1）; Department of Internal Medicine, Hashimoto Municipal Hospital, Japan2）; Department of Internal medicine of Endocrinology & Metabolism, Hashimoto Municipal Hospital, Wakayama, Japan3）; Department of Orthopedics, Hashimoto Municipal Hospital, Japan4）; Department of Cardiology, Hashimoto Municipal Hospital, Japan5）; Department of Respiratory Medicine and Allergology, Kindai University School of Medicine, Japan6）; Department of Surgery, Hashimoto Municipal Hospital, Japan7） PE2-12 Ten-year trends in the prevalence of allergic diseases and their associated factors in young adults: analysis of the Hokkaido University students Munehiro Matsumoto1）, Masaru Suzuki1）, Michiko Sato1）, Yuki Abe1）, Akira Oguma1）, Nozomu Takei1）, Machiko Sasaki1）, Hirokazu Kimura1）, Kaoruko Shimizu1）, Satoshi Hashino2）, Satoshi Konno1） Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan1）; Hokkaido University Health Care Center, Japan2） PE2-13 Clinical characteristics of patients with not well-controlled severe asthma Takae Tanosaki1,2）, Hiroki Kabata1,2）, Masako Matsusaka3）, Jun Miyata4）, Katsunori Masaki1,2）, Takao Mochimaru5）, Shinichi Okuzumi1,2）, Misato Kuwae1,2）, Risa Watanabe5）, Yuto Akiyama1,2）, Keeya Sunata1,2）, Miyuki Nishie1,2）, Yusuke Suzuki6）, Koichi Sayama7）, Kenji Izuhara8）, Koichiro Asano9）, Koichi Fukunaga1,2） Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Japan1）; Keio Allergy Center, Keio University Hospital, Japan2）; Department of Laboratory of Bioregulatory Medicine, Kitasato University School of Pharmacy, Japan3）; Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan4）; Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Japan5）; Respiratory Medicine, Kitasato University Kitasato Institute Hospital, Japan6）; Respiratory Medicine, Kawasaki Municipal Hospital, Japan7）; Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Japan8）; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan9） PE2-14 Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma Naoko Higaki1）, Hiroshi Iwamoto1）, Kakuhiro Yamaguchi1）, Shinjiro Sakamoto1）, Yasushi Horimasu1）, Takeshi Masuda1）, Shintaro Miyamoto1）, Taku Nakashima1）, Shinichiro Ohshimo2）, Kazunori Fujitaka1）, Hironobu Hamada3）, Noboru Hattori1） Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan1）; Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan2）; Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan3）

Poster Session 3

Adult asthma 2 PE3-1 IL-13/15-lipoxygenase-1 axis drives intracellular glutathione oxidation in asthmatic airway epithelial cells Tadao Nagasaki1,2）, Jinming Zhao2）, Yanhan Deng2）, John B Trudeau2）, Yoshinori Minami2）, Sally E Wenzel2） Department of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Japan1）; Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, USA2） PE3-2 The single nucleotide polymorphism (SNP) rs1799971 in the µ-opioid receptor gene (OPRM1) is a novel risk factor for asthma exacerbation Kaori Kawakami1）, Tomomitsu Miyasaka1）, Yutaka Nakamura2）, Satoshi Miyata3）, Miki Sato1）, Ichiro Sora4）, Hirohito Metoki5）, Kohei Yamauchi6）, Julie A Blendy7）, Tasuku Kawano1）, Hiroaki Shimokawa3,8）, Tomoko Takahashi1）, Motoaki Takayanagi1）, Isao Ohno2） Division of Pathophysiology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Japan1）; Center for Medical Education, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan2）; Department of Evidence-Based Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan3）; Department of Psychiatry, Kobe University Graduate School of Medicine, Japan4）; Division of Public Health, Hygiene and Epidemiology Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan5）; Division of Respirology, 6） 7）

Department of Internal Medicine, Takizawa Central Hospital, Japan ; Department of Pharmacology, University of Pennsylvania Medical School, USA ; Session Poster Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan8） PE3-3 Cadherin related family member 3 activates the effector functions of neutrophils Toshiaki Shimizu1,2）, Kazuyuki Nakagome1）, Yury A Bochkov3）, Yutaka Ueda1）, Takehito Kobayashi1）, Tomoyuki Soma1）, Hiroaki Harada2）, Keishi Fujio2）, James E Gern3,4）, Makoto Nagata1） Department of Respiratory Medicine and Allergy Center, Saitama Medical University, Japan1）; Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Japan2）; Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin, USA3）; Department of Medicine, School of Medicine and Public Health, University of Wisconsin, USA4） PE3-4 T-cell death-associated gene 8 is a new biomarker for the severity and the exacerbation in bronchial asthma Hiroaki Tsurumaki1）, Haruka Aoki-Saito1）, Yasuhiko Koga1）, Makiko Sato1）, Masakiyo Yatomi1）, Asuka Jingu1）, Kenichiro Hara1）, Noriaki Sunaga1）, Seishi Yoshimi2）, Toshitaka Maeno1）, Takeshi Hisada3） Department of Respiratory Medicine, Gunma University Graduate School of Medicine, Japan1）; Tone Central Hospital, Japan2）; Gunma University, Faculty of Medicine School of Health Sciences, Japan3） PE3-5 TRPA1 channel mediates cold air-induced aggravation of airway inflammation Takahiro Matsuyama, Kentaro Machida, Yoichi Doutake, Koichi Takagi, Hiromasa Inoue Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan PE3-6 Cooperative effect of type 2 inflammatory mediators on pulmonary function in patients with severe asthma Yuki Hoshino1,2）, Tomoyuki Soma1,2）, Yoshitaka Uchida1,2）, Sachiko Miyauchi1,2）, Hidetoshi Iemura1,2）, Erika Naito1,2）, Kazuki Katayama1,2）, Ryu Sekiya1,2）, Kazuyuki Nakagome1,2）, Makoto Nagata1,2） Department of Respiratory Medicine, Saitama Medical University, Japan1）; Allergy Center, Saitama Medical University, Japan2） PE3-7 Cytokine profile in patients with asthma attack Luna Okubo1）, Naoya Takeda2）, Yoshihiro Suzuki2）, Kuniya Nakashima2）, Motoyo Asano2）, Fumika Koike1）, Akane Ide1）, Miho Akaza1）, Yasunari Miyazaki3）, Yuki Sumi1） Department of Respiratory and Science, Tokyo Medical and Dental University, Japan1）; Department of Respiratory Medicine and Allergy, Kariya Toyota General Hospital, Japan2）; Department of Respiratory Medicine, Tokyo Medical and Dental Univercity, Japan3） 492

PE3-8 Changes of the levels of eosinophil-derived protein in sputum with response to benralizumab in patients with severe asthma Toshiyuki Koya1）, Akira Saito1）, Natsumi Sakai1）, Mio Toyama1）, Keisuke Tsukioka1）, Yosuke Kimura1）, Masachika Hayashi1）, Takashi Hasegawa2）, Toshiaki Kikuchi1） Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Japan1）; Department of General Medicine, Niigata University Medical and Dental Hospital, Japan2） PE3-9 Global Asthma Network (GAN): factors associated with asthma in parents/caregivers of adolescents living in Uruguaiana, Brazil Marilyn Urrutia-Pereira1）, Herberto Chong Neto2）, Pietro Nunes Rinelli1）, Laura Simon1）, Philippa Ellwood3）, Luis García-Marcos4）, Dirceu Solé5） Federal University of Pampa, Brazil1）; Federal University of Paraná, Brazil2）; University of Auckland, New Zealand3）; University of Murcia, Spain4）; Federal University of São Paulo, Brazil5） PE3-10 The ralationship between high blood eosinophil count in asthma and metabolic condistions Asami Minamibata1,2）, Taichiro Arimoto1,2）, Yoshinori Marunaka2） Department of Respiratory Medicine, Clinic, Kyoto Industrial Health Association, Japan1）; Research Center for Clinical Respiratory Physiology, Research Institute for Clinical Physiology, Kyoto Industrial Health Association, Japan2） PE3-11 Gender-specific impact of obesity on type 2 inflammation in adults with asthma Michiyoshi Imaoka Department of Medicine, Matsuyama Kinen Hospital, Japan PE3-12 Effect of fungal sensitization on the relationship between total serum IgE and type 2 inflammation in adults with allergic asthma Michiyoshi Imaoka Department of Internal Medicine, Matsuyama Kinen Hospital, Japan

Poster Session 4

Air pollution and environmental allergens PE4-1 Clinical implications of eosinophilia among individuals from industrial area located in central Taiwan Yuhong Tsai1）, Frank Lien2）, Hong-Kai Lin1）, Lin-Lin Pan1） Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taiwan1）; Department of Medicine, Chang Gung Memorial Hospital, Taiwan2） PE4-2 Identification and immunochemical characterization of aeroallergens from penicillium oxalicum Partha Karak1）, Koyel SenGupta2）, Sharmistha Das3）, Kashinath Bhattacharya4） Department of Botany, City College (Under Calcutta University), India1）; Division of Plant Biology, Bose Institute, India2）; Durgapur Sub-Divisional Hospital, Department of Dermatology, India3）; Visva Bharati, Department of Botany, Environmental Biology Lab., India4） PE4-3 Serological analysis for IgE against the booklice liposcelis bostrychophila, a common indoor insect pest, using recombinant allergen components Osamu Ishibashi1）, Masaya Sakaguchi1）, Yuma Fukutomi2）, Yuji Kawakami3）, Takashi Inui1） Graduate School of Life & Environmental Sciences, Osaka Prefecture University, Japan1）; Clinical Research Center for Allergy & Rheumatologty, Sagamihara National Hospital, Japan2）; Laboratory of Environmental Science, FCG Research Institute Incorporation, Japan3） PE4-4 Ultrafine particles change profilin-1 and cofilin-1 in human lung microvascular endothelial cells Ansoo Jang, Pureun-Haneul Lee, Yun-Ki Lee Department of Internal Medicine, Soonchunhyang University Hospital, Republic of Korea PE4-5 Effect of different architectural styles and ventilation systems on seasonal changes of mite allergen (Der 1) levels in houses Hideharu Shirai1）, Hiromichi Yamaguchi2）, Yudai Kohara3）, Makoto Yoshida3）, Junko Ishihara4）, Jumpei Uchiyama5）, Masahiro Sakaguchi5） Environmental Allergens Info and Care, Japan1）; Yamaguchi Respiratory and Dermatology Clinic, Japan2）; Ichijo Co. Ltd, Japan3）; Laboratory of Public Health Nutrition, Azabu University, Japan4）; Laboratory of Veterinary Microbiology I, Azabu University, Japan5） PE4-6 Allergen sensitization pattern in a Japanese general adult population 1） 2） 3） 1） 1） 1） 3） otrSession Poster Asako Kitahra , Yoshiro Yamamoto , Yuma Fukutomi , Yoshiki Shiraishi , Jun Tanaka , Tsuyoshi Oguma , Masami Taniguchi , Tadashi Nagai4）, Koichiro Asano1） Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan1）; Department of Mathematics, Tokai University, Japan2）; Clinical Research Center, Sagamihara National Hospital, Japan3）; Japanese Red Cross Central Blood Institute, Japan4） PE4-7 Profile of house dust and storage mite sensitization in the Lithuanian population Gabija Bilit1）, Asta Mikinien2）, Loreta Bagdonait3）, Jolita Norknien4）, Violeta Kvedarien5,6） Vilnius University, Faculty of Medicine, Lithuania1）; UAB In novum, Lithuania2）; Vilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Lithuania3）; Vilnius Gediminas Technical University, Lithuania4）; Clinic of Chest diseases, Immunology and Allergology, Institute of Clinical Medicine, Vilnius university, Lithuania5）; Vilnius University Hospital Santaros Klinikos, Lithuania6） PE4-8 The search for polycyclic aromatic quinones with amplifying action in antigen response Kentaro Misaki1）, Hirohisa Takano2,3）, Hiroaki Kanazawa1）, Ken-ichiro Inoue1） School of Nursing, University of Shizuoka, Japan1）; Graduate School of Global Environmental Studies, Kyoto University, Japan2）; Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Japan3） PE4-9 Change in allergen sensitization prevalence in Japan between 2005 and 2017 Jun Tanaka1）, Yuma Fukutomi2）, Asako Kitahara1）, Yoshiki Shiraishi1）, Tadashi Nagai3）, Tsuyoshi Oguma1）, Koichiro Asano1） Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan1）; Clinical Research Center, Sagamihara National Hospital, Kanagawa, Japan2）; Japanese Red Cross Central Blood Institute, Tokyo, Japan3） PE4-10 Two novel allergic proteins which induce allergic asthma, from the octocoral Yuko Kato1,2,7）, Yoshiko Takeda2,4）, Yukimitsu Imahara3）, Seiji Kawamoto5）, Yoshihito Ohba6）, Kosei Shioji1） Faculty of Science, Fukuoka University, Japan1）; Tohwa Institute for Orient Studies, Tohwa University, Japan2）; Wakayama Laboratory, Biological Institute on Kuroshio, Japan3）; Graduate School of Advanced Sciences of Matter, Hiroshima University, Japan4）; Hiroshima Research Center for Healthy Aging (HiHA) and Graduate School of Integrated Sciences for Life, Hiroshima University, Japan5）; Faculty of Pharmaceutical Science, Nagasaki International University, Japan6）; Pharmaceutical Research Center, Nagasaki International University, Japan7） PE4-11 The structure of sensitization to different allergen extracts and molecules among patients with asthma in Dnipro, Ukraine Viktoriia Voloshkina, Eugenia Dytyatkovska, Katerina Gashynova Occupational Diseases and Clinical Immunology, State Establishment Dnipropetrovsk Medical Academy Ministry of Health of Ukraine, Ukraine 493

PE4-12 Animal epithelial allergen hypersensitivity and correlation of clinical symptoms Nadmid Khorloo1,2,3,4,5）, Munkhbayarlah Sonomjamts2）, Tuvshintur Naidansuren3）, Bayar-Ulzii B4）, Garid Khishigt5） Mongolian National University of Medical Sciences, Mongolia1）; Department of Pulmonology & Allergy, Mongolian National University of Medical Sciences, Mongolia2）; Department of Pulmonology & Allergy, Mongolian National University of Medical Sciences, Mongolia3）; “Effect” Allergy Asthma hospital, Mongolia4）; Monfa Trade, Mongolia5） PE4-13 New dot-blot methods for evaluating the effect of inactivators on mite and Japanese cedar pollen allergens Megumi Yoshida1,2）, Keijiro Mizukami1）, Keigo Kurata2）, Tadahiro Nasukawa1）, Jumpei Uchiyama1）, Masahiro Sakaguchi1） Laboratory of Veterinary Microbiology I, Azabu University, Japan1）; ITEA Inc., Japan2） PE4-14 Effect of Asian dust on respiratory symptoms among children with and without asthma, and their sensitivity Hideki Hasunuma1,2）, Ayano Takeuchi3）, Rintaro Ono4）, Yuko Amimoto5）, Yoon Ha Hwang6）, Itsushi Uno7）, Atsushi Shimizu8）, Yuji Nishiwaki9）, Masahiro Hashizume1）, David J Askew11）, Hiroshi Odajima4） Department of Public Health, Hyogo College of Medicine, Japan1）; Center for Environmental Information Science, Japan2）; Keio University, Japan3）; National Hospital Organization Fukuoka National Hospital, Japan4）; Uji-Tokusyukai Medical Center, Japan5）; Busan St Mary’s Hospital, Republic of Korea6）; Kyushu University, Japan7）; National Institute for Environmental Studies, Japan8）; Toho University, Japan9）; The University of Tokyo, Japan10）; University of Occupational and Environmental Health, Japan11） PE4-15 Link between air pollution and food allergy prevalence Claudia H Lau1）, Christopher M Warren2,3）, Ruchi S Gupta2） University of California, Los Angeles (UCLA) Mattel Children’s Hospital, USA1）; Lurie Children’s Hospital, Northwestern University School of Medicine, USA2）; Stanford University School of Medicine, USA3）

Poster Session 5

Allergy prevention and risk factors PE5-1 Metal patch testing at Fukuoka University from 2014 to 2019: the real world for preoperative tests Emi Sato1）, Yutaro Yamasaki2）, Akira Maeyama2）, Akie Kajita1）, Shinichi Imafuku1） Department of Dermatology, Fukuoka University Hospital, Japan1）; Department of Orthopedic Surgery, Fukuoka University Hospital, Japan2） PE5-2 Profile of Allergy: the National Picture in Vietnam Minh Duc Nguyen Tran1）, Loc Quang Le1,2）, Duy Pham Le3） Falcuty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam1）; Online Research Club, Viet Nam2）; Department of Immunology, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam3） PE5-3 Is the widespread use of paracetamol (acetaminophen) a major cause in the development of allergic diseases, especially food, in the world? Bernard Duburque French Society of Alergy, France PE5-4 Serum vitamin D levels mitigate fractional nitric oxide changes linked to Bisphenol A Myongsoon Sung1,2,3）, Man Yong Han2）, Kyung Suk Lee3） Department of pediatrics, Soonchunyang Univeristy Gumi Hospital, Republic of Korea1）; Department of Pediatrics, CHA University School of Medicine, Republic of Korea2）; Department of Pediatrics, Hangyang University Guri Hospital, Republic of Korea3） PE5-5 Comparative proteomics analysis reveals the effect of phulorotannin from Sargassum carpophyllum on activation mast cells Takuya Matsui1）, Chihiro Ito2）, Toshiyuki Shibata3）, Masataka Itoigawa4） Department of Physiology, Aichi Medical University, Japan1）; Faculty of Pharmacy, Meijo University, Japan2）; Laboatory of Marine Food Cheistry, Mie Univeristy, Japan3）; School of Sports and Health Science, Tokai Gakuen University, Japan4） PE5-6 Factors associated with prolonged egg allergy in children: a retrospective cohort study Kazunori Sakai1）, Kenta Otsuji1）, Shiro Sugiura2） Department of Pediatrics, Okinawakyodo Hospital, Japan1）; Department of Allergy and Department of Child Health, Aichi Children’s Health and 2）

Medical Center Health and Allergy, Japan Session Poster PE5-7 Early-life skin barrier function and eczema development in Chinese infants Yehao Chen1）, Yee Kwan Ho1）, Man Fung Tang1）, Wing Hung Tam2）, Ting Fan Leung1） Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong1）; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong2） PE5-8 Gut microbiome in early life may predispose to food sensitization in infants with atopic dermatitis Seon Mi Jeong1）, Yoon Mee Park1）, So-Yeon Lee2）, Bong-Soo Kim3）,DongInSuh4）, Youn Ho Shin5）, Kyung Won Kim6）, Kamgmo Ahn7）, Soo-Jong Hong2） Department of Pediatrics, University of Ulsan College of Medicine, Republic of Korea1）; Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, Republic of Korea2）; Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Republic of Korea3）; Department of Pediatrics, Seoul National University College of Medicine, Republic of Korea4）; Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Republic of Korea5）; Department of Pediatrics, Yonsei University of Medicine, Republic of Korea6）; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea7） PE5-9 Impact of vitamin D deficiency on development and current symptom of allergic diseases Yuki Okada, Takanori Imai, Toshinori Nakamura, Mayu Maeda, Taro Kamiya, Katsumi Mizuno Department of Pediatrics, Showa University, Japan PE5-10 Kawasaki disease, specific intractable diseases and cancers in Japan began to increase in their occurrence during 1978-86, and are categorized as pollen diseases Akira Awaya1）, Yoshiyuki Kuroiwa2） Dermatology & Epidemiology Research Institute (DERI), Japan1）; Department of Neurology, Teikyo University Mizonokuchi Hospital, Japan2） PE5-11 Characteristics of atopic dermatitis in Vietnamese children―a web-based survey Duy L Pham1）, Duc M Tran1）, Loc Q Le1）, Tu HK Trinh2） Medicine Faculty, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam1）; Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam2） PE5-12 Surgery in early infancy and the development of food allergies Akira Iwanaga1,3）, Tatsuhiro Mizoguchi1,3）, Masafumi Zaitsu2,3） Department of Pediatrics, Saga-Ken Medical Centre Koseikan, Japan1）; Department of Pediatrics, National Hospital Organization Ureshino Medical Center, Japan2）; Department of Pediatrics, Faculty of Medicine, Saga University, Japan3） 494

PE5-13 Infant-onset atopic dermatitis and food allergies are risk factors for environmental, animal, and pollen allergen sensitization by age 2.5 Koryo Nakayama1）, Shinya Yoshihara1）, Yoshihide Terashi1）, Noriko Kanno2）, Tomoyo Matsubara3）, Tomo Ishii4）, Akiko Iimura5）, Mari Saito6）, Manabu Miyamoto7）, Hironobu Fukuda8）, Shigemi Yoshihara1） Department of Pediatrics, Dokkyo Medical University, Japan1）; Department of Pediatrics, Nishikata Hospital, Japan2）; Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, Japan3）; Department of Pediatrics, National Hospital Organization Tochigi Medical Center, Japan4）; Himawari Children’s Clinic, Japan5）; Department of Pediatrics, Haga Red Cross Hospital, Japan6）; Department of Pediatrics, Nasu Red Cross Hospital, Japan7）; Nasu Children’s Clinic, Japan8） PE5-14 Association between blood eosinophil-derived neurotoxin levels and the onset of allergic disease in preschool children Yoshihide Terashi1）, Masaya Kato1）, Kim Chang-keun2）, Shinya Yoshihara1）, Koryo Nakayama1）, Manabu Miyamoto1）, Yusuke Ando1）, Yuji Fujita1）, Tomoyo Matsubara3）, Shigemi Yoshihara1） Department of Pediatrics, Dokkyo Medical University, Japan1）; Department of Pediatrics, Inje University-Sanggye Paik Hospital, Republic of Korea2）; Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, Japan3） PE5-15 MFGMs supplementation in milk formulas―a systematic review of randomized controlled trials with meta-analysis Dominika Ambro㶊ej, Karolina Dumycz, Piotr Dziechciarz, Marek Ruszczy㶠ski Department of Pediatrics, Medical University of Warsaw, Poland

Poster Session 6

Anaphylaxis PE6-1 A case of occupational anaphylaxis caused by beer allergy Shintaro Suzuki, Tomoyuki Kimura, Tomoki Uno, Tetsuya Homma, Akihiko Tanaka, Hironori Sagara Division of Respiratory medicine and Allergology, Department of Internal medicine, School of medicine, Showa University, Japan PE6-2 A case in Japan of anaphylactic shock to mustard in an oral food challenge Ai Kishino1）, Chinami Sasaya2） Department of Pediatrics, Tokyo Bay Urayasu/Ichikawa Medical Center, Japan1）; Department of Nutrition, Tokyo Bay Urayasu/Ichikawa Medical Center, Japan2） PE6-3 Anaphylactic shock with cardiac arrest induced by intravenous administration of metamizole sodium during laparoscopic cholecystectomy Nebojsa D Videnovic1）, Jovan M Mladenovic1）, Milan B Filipovic1）, Rasa J Mladenovic1）, Valentina P Videnovic2）, Milanka R Tatic1）, Ranko M Zdravkovic3） Medical Faculty, Yugoslavia1）; General Hospital, Yugoslavia2）; Institute of Cardiovascular Diseases, Yugoslavia3） PE6-4 A case of anaphylaxis after ingestion of alcohol beverages Takehito Fukushima1）, Koki Okabe1）, Nanae Kimura1）, Akiko Sugiyama1）, Reiko Kishikawa1）, Satoshi Honjo2）, Makoto Yoshida2） Department of Allergology, National Hospital Organization Fukuoka National Hospital, Japan1）; Department of Clinical Research, National Hospital Organization Fukuoka National Hospital, Japan2） PE6-5 A 15-year-old female with recurrent episodes of anaphylaxis to the genus allium: a case report Jongsoo Kim1）, Yukiko Hiraguchi1）, Shogo Kato2）, Saki Yamada1）, Hiromu Teramen1）, Tomoya Shingaki1）, Yusuke Kumagai1）, Takahiro Kiyomasu1）, Kenji Owa1）, Yutaka Suehiro1） Department of Pediatrics, Center of Allergy and Clinical Immunology, Osaka Saiseikai Nakatsu Hospital, Japan1）; Nakano Children’s Hospital, Japan2） PE6-6 Fasting-induced anaphylaxis: a case report Tomoaki Kunitsu1）, Kazuo Nonomura1）, Ryo Nakajima2）, Yoshihiro Maruo3）, Michihiro Hide4） Department of Pediatrics, Saiseikai Moriyama Municipal Hospital, Japan1）; Department of Pediatrics, Saiseikai Shiga Hospital, Japan2）; Department of Pediatrics, Shiga University of Medical Science, Japan3）; Department of Dermatology, Hiroshima University, Japan4） PE6-7 A case of abalone anaphylaxis in which Skin Prick Test (SPT), Basophil Activation Test (BAT) and Oral Food Challenge (OFC) were useful for diagnosis

otrSession Poster Kazuyuki Chibana, Hiroko Morita, Yuki Ohoka, Hiroshi Ito, Nobuhiko Uchida, Yusuke Nakamura, Meitetsu Masawa, Hiroaki Okutomi, Tatsuya Yokoyama, Sayo Soda, Naoya Ikeda, Taichi Shiobara, Ryo Arai, Masaaki Miyoshi, Akihiro Takemasa, Yasuo Shimizu, Seiji Niho Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine, Japan PE6-8 Simultaneous onset of oral mite anaphylaxis in siblings after ingesting tacos Kota Ikari, Moeri Tuji, Masaru Kawamura, Takuya Oda, Junichiro Tezuka Department of Allergy and Pulmonology, Fukuoka Children’s Hospital, Japan PE6-9 A case of milk allergy that once acquired complete tolerance, but anaphylaxis began to develop later even with a small dose Moeri Tsuji, Kota Ikari, Masaru Kawamura, Takuya Oda, Junichiro Tezuka Department of Allergy and Pulmonology, Fukuoka Children’s Hospital, Japan PE6-10 A case of allergy to barley, beer and wheat-dependent exercise-induced anaphylaxis Natsue Ioka1）, Risa Tamagawa-Mineoka1）, Koji Masuda2）, Norito Katoh3） Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan1）; Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan2）; Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan3） PE6-11 A case of prick-to-prick test induced anaphylaxis in a patient with potato allergy Kazuyuki Chibana, Tatsuya Yokoyama, Yuki Ohoka, Hiroshi Ito, Nobuhiko Uchida, Yusuke Nakamura, Meitetsu Masawa, Hiroaki Okutomi, Hiroko Morita, Sayo Soda, Naoya Ikeda, Taichi Shiobara, Ryo Arai, Masaaki Miyoshi, Akihiro Takemasa, Yasuo Shimizu, Seiji Niho Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine, Japan PE6-12 A case of anaphylaxis to Measles-Mumps-Rubella (MMR) vaccine in an Infant with cow’s milk allergy Rapisa Nantanee1）, Pantipa Chatchatee1）, Jettanong Klaewsongkram2）, Supranee Buranapraditkun2）, Jongkonnee Wongpiyabovorn3）, Jarungchit Ngamphaiboon1）, Narissara Suratannon1） Pediatric Allergy and Clinical Immunology Research Unit, Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Thailand1）; Skin and Allergy Research Unit, Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Thailand2）; Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology, Faculty of Medicine, Thailand3） 495

PE6-13 Two cases of onion-induced anaphylaxis Yuki Suzuki1）, Yuri Takeshita1）, Fuminori Tomyo1）, Hikaru Toyota1）, Hirokazu Sakasegawa1）, Konomi Kobayashi1）, Naoya Sugimoto1）, Michio Kuramochi1）, Risa Shiragami2）, Keisuke Aita2）, Masaaki Hagiya2）, Hiroyuki Nagase1）, Masao Yamaguchi2） Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Japan1）; Division of Respiratory Medicine, Third Department of Medicine, Teikyo University Chiba Medical Center, Japan2） PE6-14 The changes in patterns of anaphylaxis over 10 years and the risk factors of severe anaphylactic reactions Hee-Kyoo Kim, Gil-Soon Choi Department of Internal medicine, Kosin University College of Medicine, Republic of Korea PE6-15 Pediatric anaphylaxis: clinical features, inducers and treatment in Latin America and Spain Edgardo Jares, Victoria Cardona, Alberto J Lavrut, María C Díaz, María V Souza, Mara M Rocha-Feliz, Blanca Morfin-Maciel, Mario Sánchez-Borges, Jonathan A Bernstein, Iris Alé, Nelson Rosario, Pablo Slullitel, Silvana Monsell, Alicia De Falco, Pedro Piraino, Perla Alcaraz-Duarte, Oscar Calderón-Llosa, Oscar Moreno-Laflor, German Ramon, Maximiliano Gómez SLAAI Anaphylaxis Commitee, Argentina PE6-16 A prefecture-wide survey on the management of anaphylaxis in public schools Chisa Kumagai1,2）, Minako Kawamoto1,2）, Tomoko Kaneyama1,2）, Saori Kadowaki1,2）, Norio Kawamoto1,2） Department of Pediatrics, Graduate School of Medicine, Gifu University, Japan1）; Allergy Center, Gifu University Hospital, Japan2） PE6-17 Safety of prescription of an Adrenaline auto-injector at our hospital Yukiko Otsuka, Tomonori Kadowaki, Yuki Okada, Kanako Maruta, Kumiko Miyazaki, Koji Tatebayashi, Michinori Funato, Hideo Kaneko Department of Pediatrics, National Hospital Organization Nagara Medical Center, Japan PE6-18 Analysis of EpiPen usage in Japan based on questionnaires about food allergy accidents Kumi Mizutani1）, Erina Kato2）, Ayako Saito1）, Kaoru Okamoto2）, Yuji Mori1）, Manabu Kawai2）, Yuriko Okubo2）, Kenichi Tanaka3）, Yoichi Nakajima2）, Atsuo Urisu4）, Yasuto Kondo1） Department of Pediatrics, Fujita Health University Bantane Hospital, Japan1）; Department of Pediatrics, Fujita Health University, Japan2）; Tanaka Pediatric Clinic, Japan3）; Urisu Clinic, Japan4） PE6-19 Trends and determinants in epinephrine auto-injectable prescriptions: an outpatient population-based study in Italy Marco Caminati1）, Enrico Costa2,4）, Federico Tedeschi3）, Damiano Salazzari3）, Francesco Amaddeo3）, HGM Leufkens4）, Margherita Andretta5）, Gianenrico Senna1） Department of Medicine, University of Verona; Allergy Unit and Asthma Center, Verona University Hospital, Italy1）; Department of Pharmacy University Hospital of Verona, Italy2）; Department of Neurosciences, Biomedicine and movement science, Section of Psychiatry and Clinical Psychology University of Verona, Denmark3）; WHO Collaborating Centre for Pharmaceutical Policy and Regulation, Utrecht University, Netherlands4）; HTA Unit, Azienda Zero, Veneto Region, Italy5） PE6-20 Characteristics of anaphylaxis in between children and adults: a prospective observational study Seiro Oya1）, Kosaku Kinoshita2）, Hirohisa Kinoshita3） Department of Emergency Medicine, Shizuoka Medical Center, Japan1）; Department of Emergency and Critical Care Medicine, Nihon University Itabashi Hospital, Japan2）; Department of Emergency and Critical Care Medicine, Yokohama Rosai Hospital, Japan3） PE6-21 What are the culprits in perioperative anaphylaxis? experience from an allergy centre at Wythenshawe Hospital, United Kingdom Su Xin Lim1）, Marina Tsoumani1,2）, Susana Marinho1,2）, Jia Li Liau1） Allergy Centre, Wythenshawe Hospital, Manchester University National Health Service Foundation Trust, UK1）; University of Manchester, UK2）

Poster Session 7

Animal models 1 PE7-1 Macrophages produce through the interaction with antigen specific Th2 cells Iwasaki1,2）, Seigo Terawaki1）, Hirokazu Sakamoto2）, Kishiko Sunami2）, Fuminori Tokunaga1） 1） Department of Pathobiochemistry, Graduate School of Medicine, Osaka City University, Japan ; Department of Otolaryngology-Head and Neck Session Poster Surgery, Graduate School of Medicine, Osaka City University, Japan2） PE7-2 Effector T cells are able to proliferate in the presence of activated non-cognate Foxp3+ Treg cells Yoshihiro Oya1,2,4）, Hidekazu Futami2）, Takuya Nakazawa2）, Ryutaro Matsumura2）, Hiroshi Nakajima3）, Ethan Shevach4） Laboratory of Autoimmune diseases, National Hospital Organization Chibahigashi National Hospital, Japan1）; Department of Rheumatology, Allergy & Clinical Immunology, National Hospital Organization Chibahigashi National Hospital, Japan2）; Division of Allergy and Immunology, Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Japan3）; National Institute of Allergy and Infectious Diseases/National Institutes o f Health, USA4） PE7-3 Identification of two distinct subpopulations among basophils in the bone marrow Junya Ito1）, Kensuke Miyake1）, Shigeyuki Shichino2）, Yoshinori Yamanishi1）, Hajime Karasuyama1） Inflammation, Infection and Immunity Laboratory, Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Japan1）; Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute of Biomedical Sciences, Tokyo University of Science, Japan2） PE7-4 Risk management of L-Asparaginase-induced allergy: focusing on the influence of concomitant drugs Ai Nogami-Hara1）, Yuta Hori1）, Chie Mitsuhata1）, Koji Kajiyama1）, Kentaro Susuki1）, Akira Shimada2）, Mitsunobu Mio1） Laboratory of Pharmacology, School of Pharmacy, Shujitsu University, Japan1）; Department of Pediatrics Hematology/Oncology, Japan2） PE7-5 Eosinophilic inflammation is involved in peritoneal fibrosis Takehito Kobayashi1,2,3）, Kohei Saito1）, Toru Noguchi1）, Yutaka Ueda2,4）, Yoshitaka Uchida2,3）, Tomoyuki Soma2,3）, Kazuyuki Nakagome2,3）, Hidetomo Nakamoto1）, Makoto Nagata2,3） Department of General Internal Medicine, Saitama Medical University, Japan1）; Allergy Center, Saitama Medical University, Japan2）; Department of Respiratory Medicine, Saitama Medical University, Japan3）; Department of Pediatrics, Saitama Medical University, Japan4）

PE7-6 Intranasal irradiation with narrowband-ultraviolet B suppresses nasal symptoms and up-regulation of histamine H1receptor mRNA in the nasal mucosa of rat model of allergic rhinitis Seiichiro Kamimura1）, Yoshiaki Kitamura1）, Tatsuya Fujii1）, Hiroyuki Fukui2）, Hiroyuki Mizuguchi3）, Noriaki Takeda1） Department of Otolaryngology, Tokushima University Hospital, Japan1）; Molecular Studies for Incurable Diseases, Tokushima University Graduate School, Japan2）; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Japan3） 496

PE7-7 Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33 Seiji Kamijo1）, Kei Matsuno4）, Norihiro Harada4）, Susumu Nakae5）, Takehiko Yokomizo3）, Hideoki Ogawa2）, Shigaku Ikeda1,2）, Ko Okumura1）, Toshiro Takai1） Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Japan1）; Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Japan2）; Department of Biochemistry, Juntendo University Graduate School of Medicine, Japan3）; Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Japan4）; Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Japan5） PE7-8 The establishment of a mouse model of allergic conjunctivitis induced by Japanese cedar pollen Saori Ohmae1）, Katsuyo Ohashi-Doi1）, Kosumo Hashida1）, Mikiko Okano-Yokoyama2,3）, Kiyoshi Hirahara2）, Toshinori Nakayama2） Torii Pharmaceutical Co., Ltd., Japan1）; Department of Immunology, Graduate School of Medicine, Chiba University, Japan2）; Department of Ophthalmology, Graduate School of Medicine, Juntendo University, Japan3） PE7-9 Modulatory effects of diazinon on mast cell activation Miyoko Matsushima, Kazuko Atsumi, Moeko Ohara, Masahiro Takekoshi, Yuka Tsubosaki, Goki Inoue, Ko Iwaki, Yuki Hayashi, Teppei Yamashita, Tsutomu Kawabe Department of Pathophysiological Laboratory Sciences, Graduate School of Medicine, Japan PE7-10 Antigen sensitization and intestinal infiltration of eosinophils by oral administration of aluminum salt as a food additive Ayako Wakabayashi1）, Atsuko Owaki1）, Masumi Shimizu1）, Ken Iwatsuki2）, Rimpei Morita1） Department of Microbiology and Immunology, Nippon Medical School, Japan1）; Department of Nutritional Science and Food Safety, Tokyo University of Agriculture, Japan2） PE7-11 Examination of antifibrotic effect of resolvin E series belonging to ω3 fatty acid metabolite Masakiyo Yatomi1）, Yasuhiko Koga1）, Haruka Aoki-Saito1）, Makiko Sato1）, Tsurumaki Hiroaki1）, Kenichiro Hara1）, Noriaki Sunaga1）, Toshitaka Maeno1）, Satoshi Shuto2）, Takeshi Hisada3） Division of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine, Gunma University Hospital, Japan1）; Faculty of Pharmaceutical Sciences, Hokkaido University, Japan2）; Gunma University Graduate School of Health Sciences, Japan3） PE7-12 Effects of non-steroidal anti-inflammatory drugs on sensitization to the egg-white allergen ovalbumin in rats Takahiro Fukushima1）, Tomoharu Yokooji1,2）, Taiki Hirano1）, Yuta Kataoka1）, Takanori Taogoshi1）, Hiroaki Matsuo1） Department of Pharmaceutical Services, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan1）; Department of Frontier Science for Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan2）

Poster Session 8

Animal models 2 PE8-1 Deficiency of a principal cysteine persulfide synthase aggravated airway allergic inflammation in a mouse model of asthma Yusaku Sasaki1）, Tadahisa Numakura1）, Mitsuhiro Yamada1）, Ayumi Suzuki1）, Naoya Fujino1）, Tomohiro Ichikawa1）, Akira Koarai1）, Takaaki Akaike2）, Naoto Ishii3）, Hisatoshi Sugiura1）, Masakazu Ichinose1） Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Japan1）; Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Japan2）; Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Japan3） PE8-2 Involvement of IL-5 produced from type 2 Innate Lymphoid Cells (ILC2) in acquisition of steroid resistance in a severe asthma model of mice Takeshi Nabe, Masaya Matsuda, Hayato Shimora, Kennosuke Hashimoto, Mari Minagawa, Naoki Takemoto, Miku Nomura, Ryogo Terakawa, Maki Matsuo, Ayaka Mori, Takumi Ishikawa, Kazuyuki Kitatani Department of Immunopharmacology, Pharmaceutical Sciences, Setsunan University, Japan PE8-3 Inhibitory effect of paquinimod on neutrophilic asthma of murine model Jong-Sook Park1）, Jong-Uk Lee1）, Myung-Sin Kim2）, Choon-Sik Park1） 1） otrSession Poster Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Republic of Korea ; Department of Internal Medicine, Soonchunhyang University Gumi Hospital, Republic of Korea2） PE8-4 Deletion of elongation of very long chain fatty acids family member 6 (Elovl6) enhances OVA-induced type 2 and non-type 2 allergic airway inflammation in mice Kazufumi Yoshida, Yuko Morishima, Hirofumi Sakurai, Hajime Osawa, Kai Yazaki, Mingma Thsering Sherpa, Masayuki Nakajima, Masashi Matsuyama, Takumi Kiwamoto, Yosuke Matsuno, Yukio Ishii, Nobuyuki Hizawa Department of Pulmonary Medicine, University of Tsukuba, Japan PE8-5 Nerve growth factor exacerbates airway hyperresponsiveness via epithelial damage by neutrophils-derived singlet oxygen in a mouse model of asthma with mixed inflammation Hirohisa Ogawa1）, Masahiko Azuma2,3）, Aya Umeno4,5）, Mayuko Shimizu1）, Takaaki Tsunematsu1,7）,MayoKondo3）, Kazutoshi Murotomi6）, Koichi Tsuneyama1）, Yasuhiko Nishioka3） Department of Pathology and Laboratory Medcine, Graduate School of Medical Science, Tokushima University, Japan1）; Research Center for Education of Health Bioscience, Graduate School of Medical Science, Tokushima University, Japan2）; Department of Respiratory Medicine and Rheumatology, Graduate School of Medical Science, Tokushima University, Japan3）; Health Research Institute, National Institute of Advanced Industrial Science and Technology, Japan4）; Department of Ophthalmology, Shimane University Faculty of Medicine, Japan5）; Biomedical Research Institute, Advanced Industrial Science and Technology, Japan6）; Department of Oral Molecular Pathology, Graduate School of Medical Science, Tokushima University, Japan7） PE8-6 BALF Lysophosphatidylcholine (16:0) is a possible universal biomarker for bronchial asthma by several mouse model Yusuke Nakamura1）, Yasuo Shimizu1）, Yasuhiro Horibata2）, Yusuke Kitazawa3）, Nobuhio Uchida1）, Hiroko Morita4）, Ryo Arai1）, Kazuyuki Chibana1）, Akihiro Takemasa1）, Kenjiro Matsuno3）, Hiroyuki Sugimoto2） Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan1）; Department of Biochemistry, Dokkyo Medical University, Japan2）; Department of Anatomy (Macro), Dokkyo Medical University, Japan3）; Department of Respiratory Medicine, Kanazawa University, Japan4） PE8-7 Comprehensive gene expression analysis using RNA-seq in airway of alternaria-induced asthma mice model Hideki Inoue, Megumi Matsuda, Kaho Akimoto, Megumi Jinno, Teru Haba, Tetsuya Homma, Shin Ohta, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University, Japan 497

PE8-8 Fusion protein tTIM vaccine suppresses skewed Th2 response in a murine model of allergic airway Lihua Mo1）, Xiangqian Luo1）,DaboLiu1）, Pingchang Yang2） Department of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medical University, China1）; Shenzhen University, China2） PE8-9 Repeated inhalation of salbutamol induced the development of M2 macrophages in OVA-induced mouse model of asthma Megumi Jinno, Shin Ohta, Haruna Sato, Tomoki Uno, Yoshitaka Uchida, Tomoyuki Kimura, Kuniaki Hirai, Yoshito Miyata, Yasunari Kishino, Hideki Inoue, Tetsuya Homma, Mayumi Yamamoto, Sojiro Kusumoto, Yoshio Watanabe, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University, Japan PE8-10 Establishment of a human severe asthma model using humanized mice Shiho Yamada1）, Shuichiro Maruoka1）, Asami Fukuda1）, Yusuke Kurosawa1）, Shota Toyoshima3）, Yoshimichi Okayama3）, Ryoji Ito2）, Mamoru Ito2）, Yasuhiro Gon1） Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Japan1）; Central Institute for Experimental Animals, Japan2）; Allergy and Immunology Research Project Team, Research Institute of Medical Science, Nihon University School of Medicine, Japan3） PE8-11 Differential role of TLR4 in distinct induction of house dust mite-mediated allergic airway inflammation Takashi Ishii1,2）, Yusuke Murakami1）, Tomoya Narita1）, Hiroki Nunokawa1）, Takahide Nagase2）, Naomi Yamashita1） Department of Pharmacotherapy, Research Institute of Pharmaceutical Sciences, Musashino University, Japan1）; Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Japan2） PE8-12 Regulatory effect of fungal oligonucleotide in a mouse model of bronchial asthma through suppressing Th2 immune response Shugo Suzuki1）, Tomomitsu Miyasaka2）,KoSato3）, Jun Kasamatsu3）, Keiko Ishii1）, Kaori Kawakami2）, Tomoko Takahashi2）, Isao Ohno4）, Kazuyoshi Kawakami1,3） Department of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, Japan1）; Division of Pathophysiology, Department of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Japan2）; Department of Intelligent Network for Infection Control, Tohoku University Graduate School of Medicine, Japan3）; Center for Medical Education, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan4） PE8-13 Examination by age of mice in Df-induced asthma model Shin Ohta, Tomoko Kawahara, Hatsuko Mikuni, Tomoki Uno, Haruna Sato, Yoshitaka Uchida, Tomoyuki Kimura, Megumi Jinno, Yoshito Miyata, Kuniaki Hirai, Yasunari Kishino, Hideki Inoue, Tetsuya Homma, Mayumi Yamamoto, Yoshio Watanabe, Sojiro Kusumoto, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University, Japan PE8-14 Angiotensin-converting enzyme 2 (ACE2) activator attenuates house dust mite-induced allergic inflammation in mice Asami Fukuda, Shuichiro Maruoka, Shiho Yamada, Yusuke Kurosawa, Yutaka Kozu, Yasuhiro Gon Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Japan PE8-15 Inhibition of IL-23 attenuates airway hyperresponsiveness and inflammation in a murinemodel of neutrophilic asthma Satoru Senoo1）, Akihiko Taniguchi1）, Junko Itano1）, Lili Guo2）, Naohiro Oda1）, Akihiko Yoshimura3）, Katsuyuki Kiura1）, Yoshinobu Maeda1）, Nobuaki Miyahara1,3） Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan1）; Department of Medical Technology, Okayama University Graduate School of Health Sciences, Japan2）; Department of Microbiology and Immunology, Keio University School of Medicine, Japan3） PE8-16 Conventional type 2 lung dendritic cells in asthma mouse model significantly induce follicular helper T cells than conventional type 1 Shogo Sakurai1）, Kazuki Furuhashi1,2）, Ryo Horiguchi3）, Masato Karayama1）, Yuzo Suzuki1）, Hironao Hozumi1）, Noriyuki Enomoto1）, Tomoyuki Fujisawa1）, Yutaro Nakamura1）, Naoki Inui1）, Takafumi Suda1） Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Japan1）; Department of laboratory medicine, Hamamatsu University School of Medicine, Japan2）; Advanced Research Facilities and Services, Hamamatsu University School of Medicine, Japan3）

Poster Session 9 otrSession Poster Atopic dermatitis 1 PE9-1 Long-term outcomes of 0.1% tacrolimus eye drop in eyes with severe allergic conjunctival diseases Hiroyuki Yazu1,2）, Kazumi Fukagawa2,3）, Eisuke Shimizu2）, Hiroshi Fujishima1,2,3） Department of Ophthalmology, Tsurumi University School of Dental Medicine, Japan1）; Department of Ophthalmology, Keio University School of Medicine, Japan2）; Ryogoku Eye Clinic, Japan3） PE9-2 Successful topical treatment with ketoconazole for facial rashes refractory to dupilumab in patients with atopic dermatitis Naoko Okiyama1）, Ken Igawa2） Department of Dermatology, University of Tsukuba, Japan1）; Department of Dermtology, Dokkyo Medical University School of Medicine, Japan2） PE9-3 Dupilumab treatment for atopic dermatitis leading to unexpected development of arthritis and enthesitis with increased serum IL-6: a case report Takuya Nakazawa1）, Hidekazu Futami1）, Yoshihiro Oya1）, Kazuyuki Ishijima1）, Keiko Umemiya1）, Emiko Tanabe2）, Ryutarou Matsumura1） Department of Rheumatology, Allergy & Clinical Immunology, National Hospital Organization Chibahigashi National Hospital, Japan1）; Department of dermatology, Asahicho clinic, Japan2） PE9-4 The contribution of L-type amino acid transporter 1 in activated Th2 cells for the development of atopic dermatitis Osamu Kaminuma1,3,5）, Keitaro Hayashi2）, Tomoe Nishimura3）, Mayumi Saeki3）, Takachika Hiroi3）, Yohei Iwata4）, Kazumitsu Sugiura4）, Akio Mori3,5） Department of Disease Model, Hiroshima University, Japan1）; Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan2）; Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Japan3）; Department of Dermatology, Fujita Health University School of Medicine, Japan4）; Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Japan5） PE9-5 Differences of duration of effect of each moisturizer to dry skin surface Katsuhito Iikura Department of Pediatrics, National Hospital Organization Nishisaitama chuo National Hospital, Japan PE9-6 The effect of hospitalization on a year-ling prognosis of moderate to severe atopic dermatitis Masataka Suehiro, Akio Tanaka, Hide Michihiro Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan 498

PE9-7 Efficacy and fastness of antigen specific intradermal immunotherapy using Maximum Intradermally Tolerated Dose (MITD) in patients with refractory atopic dermatitis Kyoko S Nishikage1,2）, Takeharu Yamanaka2） Yokohama Nishikage Clinic:kids and allergies, Japan1）; Department of Biostatistics, School of Medicine, Yokohama City University, Japan2） PE9-8 The plasma miR223 level might be a useful diagnostic biomarker for severe atopic dermatitis Risa Tamagawa-Mineoka, Risa Yasuike, Naomi Nakamura, Koji Masuda, Norito Katoh Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan PE9-9 High-throughput screening for potent inhibitor of Staphylococcus aureus derived from atopic dermatitis Tomofumi Numata, Kazumasa Iwamoto, Ryu Miyake, Michihiro Hide Department of Dermatology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan PE9-10 Critical windows of air pollution exposure during pregnancy on offspring’s atopic dermatitis: COCOA study Song-I Yang1）, Hae Ran Lee1）, Hyo-Bin Kim2）, So-Yeon Lee3）, Hwan-Cheol Kim4）, Min Ji Park3）, Hyeon-Jong Yang5）, Kangmo Ahn6）, Kyung Won Kim7）, Youn Ho Shin8）,DongInSuh9）, Soo-Jong Hong3） Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Republic of Korea1）; Department of Pediatrics, Inje University Sanggye Paik Hospital, Republic of Korea2）; Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, Republic of Korea3）; Department of Occupational and Environmental Medicine, Inha University School of Medicine, Republic of Korea4）; Department of Pediatrics, Soonchunhyang University School of Medicine, Republic of Korea5）; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea6）; Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Republic of Korea7）; Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Republic of Korea8）; Department of Pediatrics, Seoul National University College of Medicine, Republic of Korea9） PE9-11 Gut linoleic acid is associated with the severity of atopic dermatitis and sensitization to egg white/milk in infants So-Yeon Lee1）, Yoon Mee Park2,3）, Hyun Ju Yoo4）,DongInSuh5）, Youn Ho Shin6）, Kyung Won Kim7）, Kangmo Ahn8）, Soo-Jong Hong2） Department of Pediatrics, Asan Medical Center, Republic of Korea1）; Department of Pediatrics, Childhood Asthma and Atopy Center,, Republic of Korea2）; Asan Institute for Life Sciences, University of Ulsan College of Medicine, Republic of Korea3）; Department of Convergence Medicine, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Republic of Korea4）; Department of Pediatrics, Seoul National University College of Medicine, Republic of Korea5）; Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Republic of Korea6）; Department of Pediatrics, Yonsei University College of Medicine, Republic of Korea7）; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea8） PE9-12 Moderate-intensity aerobic exercise reduces allergic inflammation in a mouse model of atopic dermatitis Young Yoo1,2）, Wonsuck Yoon1）, Dasarang Kim1）, Jaehoon Lim1）, In Soon Kang1）, Hyo Sun Lee1）, Seunghyun Kim1）, Dae Jin Song1,2） Allergy Immunology Center, Korea University, Republic of Korea1）; Department of Pediatrics, Korea University College of Medicine, Republic of Korea2） PE9-13 Role of toxocariasis in formation and course of atopic dermatitis Revaz Sepiashvili1）, Sopio Gamkrelidze2）, Manana Chikhladze2,3）, Darejan Khachapuridze2,3） Peopels Friendsip University of Russia, Russian Federation1）; National Institute of Allergology, Asthma and Clinical Immunology, Georgian Academy of Sciences, Georgia2）; Akaki Tsereteli State University, Faculty of Medicine, Georgia3） PE9-14 Epidemiologic alpeculiarities of allergic dermatitis in children and adolescents in the population of Georgia Revaz Sepiashvili1）, Darejan Khachapuridze2,3）, Manana Chikhladze2,3）, Nino Adamia4）, Maya Maglaperidze1） Peopels Friendship University of Russia, Russian Federation1）; National Institute of Allergology, Asthma and Clinical Immunology, Georgian Academy of Sciences, Georgia2）; Akaki Tsereteli State University, faculty of Medicine, Georgia3）; Tbilisi State Medical University, Georgia4）

Poster Session 10

Atopic dermatitis 2 PE10-1 A case of iatrogenic cushing’s syndrome due to corticosteroid and antihistamine combination therapy for pediatric atopic dermatitis

otrSession Poster Mai Yokoyama, Norio Kawamoto, Chisa Kumagai, Saori Kadowaki, Tomohiro Hori, Takahiro Yamamoto, Kazuo Kubota, Takeshi Kimura, Minako Kawamoto, Hidenori Ohnishi Department of Pediatrics, Graduate School of Medicine, Gifu University, Japan PE10-2 Close association of dog exposure and the exacerbation in two cases of atopic dermatitis with dog allergy Kanako Ogura, Haruhi Yamada, Ayaka Ariyoshi Department of Dermatology, Kobe City Hospital Organization Kobe City Medical Center West Hospital, Japan PE10-3 Dietary habits in adult Japanese patients with atopic dermatitis Naoko Kanda1）, Michiko Ito2）, Takashi Morita1）, Shizuka Okazaki1）, Mototaka Koto1）, Yuri Ichikawa1）, Ryoko Takayama2）, Toshihiko Hoashi2）, Hidehisa Saeki2） Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Japan1）; Department of Dermatology, Nippon Medical School, Japan2） PE10-4 A survey of clinical practice of atopic dermatitis for dermatologists in Japan Sakae Kaneko1）, Takeshi Nakahara2）, Hiroyuki Murota3）, Akio Tanaka4）, Yoko Kataoka5）, Takeyasu Kakamu6）,NoritoKato7） Department of Dermatology, Shimane University Faculty of Medicine, Japan1）; Division of Skin Surface Sensing, Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Japan2）; Department of Dermatology, Nagasaki University Graduate School of Medicine, Japan3）; Department of Dermatology, Graduate school of Biomedical & Health Sciences, Hiroshima University, Japan4）; Department of Dermatology, Osaka Habikino Medical Center, Japan5）; Department of Hygiene & Preventive Medicine, Fukushima Medical University School of Medicin, Japan6）; Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan7） PE10-5 Dupilumab induces eight categories of facial responses in atopic dermatitis: a long-term, single-center, observational study Yoko Kataoka, Rai Fujimoto, Sachiko Sakamoto, Ayaki Shigyo, Hirohiko Shirai, Eiji Kawasaki Department of Dermatology, Osaka Habikino Medical Center, Japan PE10-6 Dupilumab for a girl with severe asthma, atopic dermatitis, and school refusal Satoshi Yamada1）, Yutaka Nishida1）, Shun Takahashi1）, Naoya Arakawa1）, Toru Uchida1）, Koichiro Sato2）, Satomi Hagiwara1,3）, Hisako Yagi1）, Hirokazu Arakawa1）, Takumi Takizawa1） Department of Pediatrics, Gunma University Graduate School of Medicine, Japan1）; Department of Pediatrics, Takasaki General Medical Center, Japan2）; Shigeta Child Allergy Clinic, Japan3） 499

PE10-7 Continued treatment with dupilumab (LIBERTY AD OLE) provides clinical benefits in most adults with moderate-to-severe atopic dermatitis not achieving optimal response to short-term treatment Joo Young Roh1）, Young Lip Park2）, Chun Wook Park3）, Zhen Chen4）, Arima Kazuhiko5）, Oh EunSil6）, Brad Shumel4）,AnaBRossi7） Gachon University, Gil Medical Center, Republic of Korea1）; Soonchunhyang University, College of Medicine, Republic of Korea2）; Hallym University, College of Medicine, Republic of Korea3）; Regeneron Pharmaceuticals, Inc., USA4）; Sanofi K.K., Japan5）; Sanofi-aventis, Republic of Korea6）; Sanofi Genzyme, USA7） PE10-8 Difference between the characteristics of inpatients with skincare for Atopic Dermatitis (AD) in 2009 and 2018 in our department Yoko Murakami1）, Masaaki Kawano1）, Daisuke Yasunari1）, Takeshi Oki1）, Koki Okabe1）, Kento Fukushima1）, Mihoko Iwata1）, Masatoshi Wakatsuki1）, Naohiko Taba1）, Hiroshi Matsuzaki1）, Chikako Motomura1）, Satoshi Honjyo1,2）, Akiko Sugiyama1,2）, Hiroshi Odajima1） Department of Pediatrics, National Hospital Organization Fukuoka Nartional Hospital, Japan1）; Department of Dermatology, National Hospital Organization Fukuoka National Hospital, Japan2） PE10-9 The case series study for the specific phenotypes of atopic dermatitis with rapid response to the treatment with dupilumab Rai Fujimoto, Hidefumi Kawasaki, Sachiko Sakamoto, Ayaki Shigyo, Hirohiko Shirai, Yoko Kataoka Department of Dermatology, Osaka Habikino Medical Center, Japan PE10-10 Different preferences between patients and physicians for the treatment of atopic dermatitis in Japan Yukari Okubo1）, Kerrie-Anne Ho2）, Simon Fifer2）, Hiroyuki Fujita3）, Yasuyo Oki3）, Yurie Taguchi3） Department of Dermatology, Tokyo Medical University, Japan1）; Community and Patient Preference Research Pty Ltd (CaPPRe), Australia2）; Sanofi K.K., Japan3） PE10-11 A real-world treatment landscape of atopic dermatitis in Japan Kazumasa Kamei1）, Hidehisa Saeki2）, Takanori Tsuchiya1）, Tomohiro Hirose1）, Eduardo Kawasaki1）, Fumihiro Matsumoto1）, Noritoshi Yoshii1）, Shinichi Imafuku3） Pfizer Japan Inc., Japan1）; Department of Dermatology, Nippon Medical School, Japan2）; Dermatology, Fukuoka University, Japan3） PE10-12 Dupilmab is effective for the treatment of intractable prurigo in adult atopic dermatitis Satoshi Takeuchi, Mari Kiyomatsu-Oda Department of Dermatology, Federation of National Public Service Personnel Mutual Aid Associations, Hamanomachi Hospital, Japan PE10-13 Increased incidence of conjunctivitis with dupilumab treatment in adolescents appears to be specific to atopic dermatitis Marjolein De Bruin-Weller1）, Eric L Simpson2）, Amy S Paller3）, Elaine C Siegfried4,5）, Jonathan Corren6）, Zhen Chen7）,AnaBRossi8）, Kazuhiko Arima9）, Faisal A Khokhar7）, Ashish Bansal7） University Medical Center, The Netherlands1）; Oregon Health & Science University, USA2）; Northwestern University Feinberg School of Medicine, USA3）; Saint Louis University, USA4）; Cardinal Glennon Children’s Hospital, USA5）; David Geffen School of Medicine at UCLA, USA6）; Regeneron Pharmaceuticals, Inc., USA7）; Sanofi Genzyme, USA8）; Sanofi K.K., Japan9） PE10-14 Oral immunosuppressants in pediatric patients with moderate or severe atopic dermatitis Joaquin Pimentel1）, Mirna Toledo2）, Omar Saucedo1） Department of Allergy and Immunology, Hospital Infantil de Mexico Federico Gomez (WAO Center of Excellence), Mexico1）; Department of Dermatology, Hospital Infantil de Mexico Federico Gomez, Mexico2）

Poster Session 11

Case report: asthma and airway disease PE11-1 A case of chronic cough caused by protracted bacterial bronchitis in a patient with long-term management of asthma Rieko Higashijima1,2）, Natsuko Masumoto2）, Momoko Sakurai2）, Junichiro Tezuka3） Department of Pediatrics, Tagawa Municipal Hospital, Japan1）; Department of Pediatrics, National Hospital Organization Fukuoka-Higashi Medical Center, Japan2）; Department of Allergy and Pulmonology, Fukuoka Children’s Hospital, Japan3） PE11-2 Exercised-induced laryngeal obstruction and low end-expiratory lung volume in an asthmatic adolescent

Tai Q Tran, Huyen TK Dang, Lan TT Le Session Poster Department of Respiratory Functional Exploration, Viet Nam PE11-3 An asthmatic case of psoriasis vulgaris caused by administration of dupilumab Hideyasu Yamada1,2）, Takashi Matsuda1）, Norihito Hida2）, Nobuyuki Hizawa1） Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Japan1）; Division of Respiratory Medicine, Hitachi Ltd, Hitachinaka General Hospital, Japan2） PE11-4 Ultrasound “humidifier lung” caused by rare fungal pathogens identified in vitro: two case reports Kai Ryu1,2）, Kiyoshi Sekiya1）, Akemi Saito1）, Kentaro Watai1）, Yosuke Kamide1）, Yuma Fukutomi1）, Takanori Numata2）, Kazuyoshi Kuwano2）, Katsunori Kamei3）, Masami Taniguchi1,4） Clinical Reserch Center for Allergy and Rheumatology National Hospital Organization Sagamihara National Hospital, Japan1）; Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan2）; Mycology Research Center, Chiba University, Japan3）; Department of Allergy, Shonan Kamakura General Hospital, Japan4） PE11-5 A case of refractory allergic bronchopulmonary aspergillosis successfully switched from mepolizumab to benralizumab Chiyako Oshikata1,2）, Takeshi Kaneko2）, Naomi Tsurikisawa1,2） Department of Allergy and Respirology, Hiratsuka City Hospital, Japan1）; Department of Pulmonology, Yokohama City University Graduate School of Medicine, Japan2） PE11-6 A case of a patient with eosinophilic otitis media with progressing sensorineural hearing loss despite treatment with biological products Wakako Nakanishi1）, Michiko Uchiyama2）, Wayo Kawawaki1）, Hiroko Monobe1） Department of Otolaryngology, Japanese Red Cross Medical Center, Japan1）; Tokyo Metropolitan Police Hospital, Japan2） PE11-7 The effect of mepolizumab in asthmatic patients with chronic Haruna Sato, Hideki Inoue, Yoshito Miyata, Tetsuya Homma, Tomoki Uno, Yoshitaka Uchida, Hitomi Ida, Tomoyuki Kimura, Yousuke Fukuda, Megumi Jinno, Kuniaki Hirai, Shin Ohta, Mayumi Yamamoto, Yoshio Watanabe, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara Showa University School of Medicine, Department of Medicine, Division of Respiratory Medicine and Allergology, Japan PE11-8 A case of chronic hypersensitivity pneumonitis potentially due to past bird-raising and feather quilt use Toshiyuki Kita1）, Tomoyuki Araya1）, Tamami Sakai1）, Keigo Saeki2） Respiratory Medicine, National Hospital Organization Kanazawa Medical Center, Japan1）; Respiratory Medicine, Kanazawa University Hospital, Japan2） 500

PE11-9 A case of severe asthma controlled by dupilumab based on serum IL-4 levels Takahiko Nakamura1）, Soichiro Ikeda1）, Sho Mitsuya1）, Tomoya Funamoto1）, Kiyoe Kanaoka1）, Hiroyuki Tsuji1）, Ninso Matsunaga1）, Kenjiro Tsuruoka1）, Shuhei Yoshida1）, Yousuke Tamura1）, Masafum Imanishi1）, Yasuhito Fujisaka1）, Akihisa Imagawa2） Department of Respiratory Medicine and Thoracic Oncology, Osaka Medical College Hospital, Japan1）; Department of Internal Medicine, Osaka Medical College Hospital, Japan2） PE11-10 Two cases of chronic eosinophilic pneumonia successfully long-term treated with benralizumab Seiko Soeda, Ryuta Tsuzuki Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Japan PE11-11 Acute eosinophilic pneumonia associated with COVID-19 Koji Kuronuma, Koutaro Murao, Atsushi Saito, Hirofumi Chiba Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan PE11-12 A case of successful switching from omalizumab to mepolizumab for severe asthma with allergic bronchopulmonary mycosis Kana Oshinden, Tsuyoshi Oguma, Naoki Okada, Shigeaki Hattori, Jun Tanaka, Asako Kitahara, Katsuyoshi Tomomatsu, Koichiro Asano Department of Pulmonary Medicine, Tokai University, Japan PE11-13 The first case of allergic bronchopulmonary mycosis caused by bjerkandera adusta Kazuya Tone1）, Haruhiko Ogawa2,3）, Mina Gochi1）, Yuko Nagano4）, Susumu Saito1）, Takuya Akutsu1）, Atsuki Furube1）, Shunsuke Inaki1）, Masamichi Takagi1）, Kazuyoshi Kuwano5）, Koichi Makimura6） Department of Respiratory Medicine, The Jikei University School of Medicine, Kashiwa Hospital, Japan1）; Division of Internal Medicine, Jinchikai Hospital, Japan2）; Department of Environmental and Preventive Medicine, Kanazawa University, Japan3）; Clinical Central Laboratory, The Jikei University School of Medicine, Kashiwa Hospital, Japan4）; Division of Respiratory Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Japan5）; Graduate School of Medicine, Teikyo University, Japan6） PE11-14 A case of eosinophilic granulomatosis with polyangiitis presenting with central retinal artery occlusion Hirono Nishiyama1）, Tomoko Tajiri1）, Shinya Tamechika2）, Katsuya Suzuki3）, Ryota Kurokawa1）, Norihisa Takeda1）, Kensuke Fukumitsu1）, Yoshihiro Kanemitsu1）, Satoshi Fukuda1）, Takehiro Uemura1）, Hirotsugu Ohkubo1）, Ken Maeno1）, Yutaka Ito1）, Masaya Takemura1）,TaioNaniwa2）, Akio Niimi1） Department of Respiratory Medicine, Allergy and Clinical Immunology, Japan1）; Department of Rheumatology, Japan2）; Department of Ophthalmology, Japan3）

Poster Session 12

Case report: clinical immunology PE12-1 Intestinal tissue cytokines analysis in case of a 10 years old boy diagnosed with eosinophilic gastroenteritis Masako Chiyotanda1）, Shigeo Nishimata1）, Taro Miura2）, Ryuhei Nagao1）, Yasuyo Kashiwagi1）, Hisashi Kawashima1） Department of Pediatrics, Tokyo medical University, Japan1）; Department of Pediatrics, Tokyo medical University Hachioji Medical Center, Japan2） PE12-2 Identification of allergens causing reactions at the sites of venous access using delayed hypersensitivity assays Slawomir M Kosinski1）, Roberto V Nachajon2） Division of Allergy and Immunology, St Joseph’s University Medical Center, USA1）; Division of Pediatric Pulmonology, St Joseph’s University Medical Center, USA2） PE12-3 Serum TARC levels before and after treatment for pruritic ordinary scabies Yukiyasu Arakawa, Risa Tamagawa Mineoka, Koji Masuda, Norito Katoh Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Japan PE12-4 PD-1 blockade might induce eosinophilic pneumonia like eosinophilic granulomatosis with polyangitiis feature Masanori Harada, Hyogo Naoi, Keisuke Morikawa, Yutaro Ito, Namio Kagoo, Tsutomu Kubota, Koshiro Ichijo, Eisuke Mochizuki, Norimichi Akiyama, Masahiro Uehara, Shun Matsuura, Masaru Tsukui, Naoki Koshimizu Department of Respiratory, Fujieda Muninciple General Hospital, Japan

otrSession Poster PE12-5 A case of toxic epidermal necrolysis-like cutaneous manifestation of systemic erythematosus Estherly Grace M Gonzales, Kristy P Villamayor, Richard John Pelo Department of Internal Medicine, Bicol Medical Center, Philippines PE12-6 Two cases of interstitial pneumonia with anti-MDA5 antibody in this hospital Kentaro Tamura1）, Ayako Kojima1）, Masahiro Yoshida1）, Zenya Saito1）, Kazuyoshi Kuwano2） Department of Internal Medicine, Division of Respiratory Medicine, Atsugi City Hospital, Japan1）; Department of Internal Medicine, Division of Respiratory Medicine, Jikei University School of Medicine, Japan2） PE12-7 Case report: unusual manifestation of lupus erythematous systemic with thalassemia B intermediate and hemolytic autoimmune anemia Muhammad Alif Fathur Rachman1）, Nova Kurniati2） Department of Internal Medicine, Moh Hoesin Palembang Hospital, Indonesia1）; Sriwijaya University, Indonesia2） PE12-8 A case of IL2RG mutation with atypical features Marzieh Tavakol1）, Zahra Tavakol2） Alborz University of Medical Sciences, Iran1）; Department of Sports & Exercises Medicine, Tehran University of Medical Sciences, Iran2） PE12-9 Systemic sarcoidosis associated with certolizumab pegol treatment for : a case report and review of the literature Keigo Koda1）, Mikio Toyoshima1）, Tsuyoshi Nozue1）, Takafumi Suda2） Department of Respiratory Medicine, Hamamatsu Rosai Hospital, Japan1）; Second Department of Internal Medicine, Hamamatsu University School of Medicine, Japan2） PE12-10 Pregnancy-related hemophagocytic lymphohistiocytosis: a report of three cases with assessing cytokines profile Takahiro Yoshikawa, Kazuaki Noguchi, Mai Nakano, Akio Tamura, Naoto Azuma, Kiyoshi Matsui Division of Allergology and Rheumatology, Department of Internal Medicine, Hyogo College of Medicine College Hospital, Japan PE12-11 Early initiation of mepolizumab for remission induction therapy in patients with eosinophilic granulomatosis with polyangiitis: report of two cases Jun Tamura1）, Minami Koriyama2）, Mari Yatomi3）, Hiroshi Nakajima4）, Tomohiro Tamachi1,4） Department of Allergy and Clinical Immunology, Chiba Rosai Hospital, Japan1）; Department of Otolaryngology, Head and Neck Surgery, Chiba Rosai Hospital, Japan2）; Department of Respiratory Medicine, Chiba Rosai Hospital, Japan3）; Department of Allergy and Clinical Immunology, Chiba University Hospital, Japan4） 501

PE12-12 Eosinophil extracellular trap formation in chronic granulomatous disease Yui Miyabe1）, Michihiro Yano2）, Mineyo Fukuchi1）, Chikako Furutani1）, Yuki Moritoki1）, Tomoo Saga1）, Tsutomu Takahashi2）, Shigeharu Ueki1） Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Japan1）; Department of Pediatrics, Akita University Graduate School of Medicine, Japan2） PE12-13 A case of muckle-wells syndrome with the skin erythema dominantly infiltrated by lymphocytes Saori Kadowaki, Takeshi Kimura, Mayuka Shiraki, Norio Kawamoto, Hidenori Ohnishi Department of Pediatrics, Gifu University Graduate School of Medicine, Japan PE12-14 Lung granulomatous disease in a patient with GATA2 mutation Motoko Yasutomi1）, Taihei Hayashi1）, Koji Suzuki1）, Genrei Ohta1）, Yasuhiro Watanabe4）, Toshihiro Takeda2）, Akitoshi Okada3）, Yusei Ohshima1） Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Japan1）; Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan2）; Division of Thoracic Surgery, Department of Surgery, University of Fukui, Japan3）; Department of Pediatrics, Fukui Red Cross Hospital, Japan4） PE12-15 Long-term follow up of a patient with hyper-IgE syndrome and STAT3 mutation: clinical complications, allergic manifestations and specific IgE antibodies Rumiko Shibata1）, Masako Kadowaki2） Department of Pediatrics, National Hospital Organization, Fukuoka National Hospital, Japan1）; Department of Internal medicine, National Hospital Organization, Fukuoka National Hospital, Japan2） PE12-17 Case report of a Swyer-James syndrome: unilateral lung perfusion scan defects questions Ágnes Németh1）, Erzsébet Péterffy2）, György Balázs3）, Andrea Bánffy4） 2nd Department of Pediatrics, Semmelweis University, Hungary1）; Pediatric Institute of “Svábhegy”, Hungary2）; Department of Radiology Heim Pál Children’s Hospital, Hungary3）; Pediatric Institute of “Svábhegy”, Hungary4） PE12-18 A pediatric case of productive cough caused by mutations in DNAH9 Kazuhiko Takeuchi1）, Yifei Xu1）, Kazuki Chiyonobu1）, Hisami Kubo1）, Guofei Feng1）, Satoru Ogawa2）, Makoto Ikejiri3）, Kaname Nakatani4）, Satoko Usui5）, Sawako Masuda5）, Mizuho Nagao6）, Takao Fujisawa6） Department of Otorhinolaryngology, Mie University, Japan1）; Electron Microscopy Research Center, Mie University, Japan2）; Department of Central Laboratories, Mie University Hospital, Japan3）; Department of Genomic Medicine, Mie University Hospital, Japan4）; Department of Otorhinolaryngology, Mie National Hospital, Japan5）; Institute for Clinical Research, Mie National Hospital, Japan6）

Poster Session 13

Case report: food allergy PE13-1 A case of pollen-food allergy syndrome with intractable oral swelling Daiki Sakamoto1）, Satoko Hamada1,2）, Yoshiki Kobayashi1,2）, Akihiro Shimamura1）, Akira Kanda1,2）, Mikiya Asako1,2）, Hiroshi Iwai1） Department of Otorhinolaryngology, Kansai Medical University, Japan1）; Allergy Center, Kansai Medical University, Japan2） PE13-2 A reaction to RACOLNF due to cow’s milk allergy: a report of two cases Yoko Inoue, Kaito Goto, Yoshiki Kitani, Ayumi Tsukahara, Yuki Koto, Takahiro Kojima Department of Pediatrics, St Marianna University School of Medicine, Japan PE13-3 Two neonatal cases of food protein-induced enterocolitis syndrome with pale stool and transient biliary dilatation Eishi Makita1）, Sae Kuroda2）, Kae Itabashi1）, Daisuke Sugawara1）, Hiroaki Sato1）, Ko Ichihashi1） Department of Pediatrics, Saitama Medical Center Jichi Medical University, Japan1）; Department of Pediatrics, Saitama Red Cross Hospital, Japan2） PE13-4 A case of triplets who developed peanut allergy on the same day Kenta Otsuji1）, Taiki Nagatsuka2）, Kazunori Sakai1）, Ryoko Amazumi1）, Chiaki Higa1） Department of Pediatrics, Okinawa Kyodo Hospital, Japan1）; Department of Intern, Okinawa Kyodo Hospital, Japan2）

PE13-5 Home-based, slow up-dosing oral immunotherapy for hen’s egg allergy in an adult patient Session Poster Satoshi Horino, Kei Uneoka, Masato Nihei, Haruka Aki, Katsushi Miura Department of Allergy, Miyagi Children’s Hospital, Japan PE13-6 Dupilumab for treatment of severe asthma and food allergy Junichiro Tezuka, Takuya Oda, Kota Ikari, Masaru Kawamura, Moeri Tsuji Department of Allergy and Pulmonology, Fukuoka Children’s Hospital, Japan PE13-7 A case of fish allergy to parvalbumin successfully treated with oral immunotherapy using cooked, hypoallergenic fish Tsukasa Ugajin1）, Yukihiro Kobayashi2）, Kaoru Takayama3）, Hiroo Yokozeki1） Department of Dermatology, Tokyo Medical and Dental University, Japan1）; Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Japan2）; Department of Dermatology, Saiseikai Kawaguchi General Hospital, Japan3） PE13-8 Two cases of anaphylactic reaction to chamomile tea in a patient with mugwort pollinosis Michiyo Nakagawa, Miho Hanada, Akemi Hamabata, Hiroo Amano Department of Dermatology, Iwate Medical University, Japan PE13-9 Device of safe food load test without hospitalization Kanae Ogura Department of Pedistrics, Kyotoyawata Hospital, Japan PE13-10 Two cases of Down’s syndrome with chronic cow’s milk-induced FPIES, one case complicated by hypovolemic shock and cerebral hemorrhage Urara Tsukagoshi1）, Mayumi Araki1）, Tamaki Ito1）, Yuki Tsumura1）, Nobuhiko Taguchi1）, Ichiro Nomura2）, Hideaki Morita3）, Masayuki Akashi4） Department of Pediatrics, Keiyu Hospital, Japan1）; Division of Eosinophilic Gastrointestinal Disorders, National Research Institute for Child Health and Development, Japan2）; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Japan3）; Department of Pediatrics, Keio University Hospital, Japan4） PE13-11 Nutritional management of atypical food protein-induced enterocolitis syndrome caused by cow’s milk formula: a case report Tomoyuki Arima, Yutaka Takemura, Hiroki Masumi, Koji Yamasaki, Megumi Nagai, Keisuke Sugimoto Department of Pediatric Kindai University Faculty of Medicine, Japan 502

PE13-12 Omalizumab for pollen-food allergy syndrome: a case report Natsuko Masumoto1）, Rieko Higashijima1）, Momoko Sakurai1）, Junichiro Tezuka2）, Yoshito Ishizaki1） Department of Pediatrics, National Hospital Organization Fukuokahigashi Medical Center, Japan1）; Department of Allergology and Respiratory Medicine, Fukuoka Children’s Hospital, Japan2） PE13-13 Dupilumab induces tolerance in gastrointestinal allergy; a case report Arakawa Naoya1）, Daisuke Shigeta2）, Hisako Yagi1）, Mariko Shimizu3）, Takumi Takizawa1）, Yoshiyuki Yamada3） Department of Pediatrics, Gunma University Graduate School of Medicine, Japan1）; Saku Central Hospital Advanced Care Center, Japan2）; Gunma Children’s Medical Center, Japan3） PE13-14 Exacerbation of an egg allergy induced by an egg-free diet for three years without an increase in food-specific IgE. case report Shigehito Emura1,2）, Saori Takahashi1）, Chisato Hori1）, Kazuo Takeuchi1）, Toshiharu Mautsui1）, Tetsuki Gunji1） Department of Pediatrics, Nagaoka Chuo General Hospital, Japan1）; Department of Pediatrics, Niigata Prefectural Shibata Hospital, Japan2） PE13-15 A case of wild sesame allergy suspected transdermal sensitization Jun Shirota, Hiroko Sakuma, Fumi Mashiyama, Naoko Suzuki, Yuka Takeda, Hisao Okabe, Eriko Shima Department of Pediatrics, Hoshi General Hospital, Japan PE13-16 A case of suspected food protein-induced enterocolitis syndrome duetoyeast(Saccharomyces cerevisiae) Koichiro Sato1,2）, Hisako Yagi2）, Toru Uchida1,2）, Mari Tokunaga1）, Naoya Arakawa2）, Satoshi Yamada2）, Yutaka Nishida2）, Takumi Takizawa2） Department of Pediatrics, Takasaki General Medical Center, Japan1）; Department of Pediatrics, Gunma University Graduate School of Medicine, Japan2） PE13-17 Allergic reaction to fish in a patient with no past allergic history Anna Sargsyan1）, Arpine Israelyan2） Izmirlian MC, Armenia1）; Spaulding Rehabilitation Network, USA2） PE13-18 A case series of solid food protein-induced enterocolitis syndrome Mai Tokunaga, Yumi Koike Department of Allergy, Nagano Children’s Hospital, Japan PE13-19 Generalized allergic reaction caused by strawberry gibberellin-regulated protein: a case report Chisato Inuo1）, Fumiko Okazaki2）, Risa Shiraki2）, Keiko Momma3）, Hiroshi Narita4） Department of allergy, Kanagawa Children’s Medical Center, Japan1）; Department of Food Science and Human Nutrition Faculty of Agriculture, Ryukoku University, Japan2）; Department of Food Science, Kyoto Women’s University, Japan3）; Kyoto College of Nutritional and Medical Sciences, Japan4）

Poster Session 14

Clinical Immunology PE14-1 A child case of recurrent hypereosinophilia caused by Streptococcus pyogenes infection Junya Abe, Hiroshi Numata, Kenji Nakagawa, Takakazu Yoshioka, Mitsutaka Shiota, Daisuke Hata Department of Pediatrics, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Japan PE14-2 Multiple hepatic aneurysm and dry gangrene off ingertips in Eosinophilic Granulomatosis with Polyangiitis (EGPA) Eunsil Koh1）, Dong-Chull Choi1）, Byung-Jae Lee1）, Young-soo Do2）, Duk-Kyung Kim1）, Jin-Young Lee3）, Noeul Kang1）, Jae-Won Jeong4）, Sang-Hoon Kim5） Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea1）; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea2）; Health Promotion Center, Samsung Medical Center, Republic of Korea3）; Department of Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Republic of Korea4）; Department of Medicine, Eulji General Hospital, Eulji University School of Medicine, Republic of Korea5） PE14-3 Presence of purpura as an important clinical index for high disease activity with increased serum IL-5 in eosinophilic granulomatosis with polyangiitis

otrSession Poster Hiroshi Kataoka, Masaya Mukai Department of Rheumatology and Clinical Immunology, Sapporo City General Hospital, Japan PE14-4 Elevated serum levels of galectin-10 in active eosinophilic granulomatosis with polyangiitis Yosuke Kamide1）, Shigeharu Ueki2）, Mineyo Fukuchi2）, Norihiro Fujita1）, Maki Iwata1）, Kisako Nagayama1）, Yuto Nakamura1）, Koichi Yano1）, Kentaro Watai1）, Yuto Hamada1）, Kai Ryu1）, Hiroaki Hayashi1）, Yuma Fukutomi1）, Kiyoshi Sekiya1）, Akio Mori1）, Masami Taniguchi1,3） Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Japan1）; Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Japan2）; Shonan Kamakura General Hospital Center for Immunology and Allergology, Japan3） PE14-5 Oligoclonal expansion of circulating Tph cells is related to the pathogenesis of IgG4-related disease Hayato Yabe1,2）, Ryuta Kamekura1,3）, Motohisa Yamamoto4）, Hirofumi Chiba2）, Hiroki Takahashi4）, Kenichi Takano3）, Hiroki Takahashi2）, Shingo Ichimiya1） Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan1）; Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan2）; Department of Otolaryngology, Sapporo Medical University School of Medicine, Japan3）; Department of Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Japan4） PE14-6 Predictive factors of the therapeutic response to mepolizumab in patients with eosinophilic granulomatosis with polyangiitis Takami Kobayashi1）, Hiroaki Tsurumaki1）, Yuji Onuki1）, Haruka Aoki-Saito1）, Yasuhiko Koga1）, Makiko Sato1）, Masakiyo Yatomi1）, Asuka Jingu1）, Koichi Yamaguchi1）, Kenichiro Hara1）, Noriaki Sunaga1）, Toshitaka Maeno1）, Takeshi Hisada2） Department of Respiratory Medicine, Gunma University Graduate School of Medicine, Japan1）; Gunma University, Faculty of Medicine School of Health Sciences, Japan2） PE14-7 Effects and mechanisms of IVIG on the inflammatory response of a cultured human coronary artery endothelial cell model of Kawasaki disease Takashi Inoue1,2）, Shokei Murakami1）, Kenji Matsumoto1）, Akio Matsuda1） Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Japan1）; Department of Pediatrics, Jikei University School of Medicine, Japan2） PE14-8 Changes of MMP-9 and MMP12 in response of acute viral infection in virtual model of macrophages Junehyuk Lee, Aerin Baek, Joohyun Park, Sung-Woo Park, Do-Jin Kim, An-Soo Jang Respiratory and Allergy, Soonchunhyang Universiy Bucheon Hospital, Republic of Korea 503

PE14-9 A novel self-pay newborn screening program for severe combined immunodeficiency in Japan Yuzaburo Inoue1,13）, Toru Uchiyama2,13）, Masafumi Onodera2,13）, Masafumi Yamada3,13）, Joo-Hyun Seo4,13）, Motomichi Kosuga4,5,13）, Ohsuke Migita6,13）, Toju Tanaka7,13）, Takuya Fushimi8,13）, Kei Murayama8,13）, Hiroshi Mochizuki9,13）, Torayuki Okuyama1,4）, Masaki Takayanagi11,13）, Akira Ohtake12,13） Department of Allergy and Rheumatology, Chiba Children’s Hospital, Japan1）; Department of Human Genetics, National Center for Child Health and Development, Japan2）; Department of Pediatrics, Hokkaiodo University Graduate School of Medicine, Japan3）; Clinical Laboratory Medicine, National Center for Child Health and Development, Japan4）; Division of Medical Genetics, National Center for Child Health and Development, Japan5）; Department of Pediatrics, St Marianna University School of Medicine, Japan6）; Center for Genetics & Metabolic Disorder and Clinical Research, National Hospital Organization Hokkaido Medical Center, Japan7）; Center for Medical Genetics, Department of Metabolism, Chiba Children’s Hospital, Japan8）; Department of Metabolic Endocrinology, Saitama Children’s Medical Center, Japan9）; Center of Lysosomal Storage Diseases, National Center for Child Health and Development, Japan10）; Department of Physical Therapy, Faculty of Health Care and Medical Sports, Teikyo Heisei University, Japan11）; Department of Pediatrics & Clinical Genomics, Faculty of Medicine, Saitama Medical University, Japan12）; Clinical & Research Association for Rare, Intractable Diseases, Japan13） PE14-10 A rare case of TTC7A deficiency presented with combined immunodeficiency and gastrointestinal defects Samin Sharafian Bushehr University of Medical Sciences, Iran PE14-11 Immunologic analysis on children with post-infectious bronchiolitis obliterans Yun Jung Choi, Jihye Kim, Minjung Kim, Ji Soo Park, Minjin Jeon, Soyoung Lee,DongInSuh Department of Pediatrics, Seoul National University Hospital, Republic of Korea PE14-12 Clinical characteristics of macrolide-refractory mycoplasma pneumoniae pneumonia in Korean children: multicenter retrospective cohort study Yun Jung Choi1）, Minjung Kim1）,DongInSuh1）, Hyeon-Jong Yang2,3）, Pneumonia and Respiratory Disease Study Group4） Department of Pediatrics, Seoul National University Hospital, Republic of Korea1）; SCH Biomedical Informatics Research Unit, Soonchunhyang University Seoul Hospital, Republic of Korea2）; Department of Pediatrics, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Republic of Korea3）; Korean Academy of Pediatric Allergy and Respiratory Disease, Republic of Korea4） PE14-13 Oral once-daily berotralstat (BCX7353) reduces hereditary angioedema (HAE) events and is well-tolerated: pivotal phase 3 study (APeX-J) results from Japan Isao Ohsawa1）, Daisuke Honda2）, Yusuke Suzuki3）, Tomoo Fukuda4）, Keisuke Koga5）, Eishin Morita6）, Shinichi Moriwaki7）, Osamu Ishikawa8）, Tomoe Kobayashi9）, Yoshihiro Sasaki10）, Masaki Tago11）, Greg Chittick12）, Sharon Murray12）, Sylvia Dobo12）, Eniko Nagy12）, Sharon Van Dyke12）, Lacy Reese12）, Phil Collis12）, William Sheridan12）, Michihiro Hide13） Department of Nephrology, Saiyu Soka Hospital, Japan1）; Juntendo University Urayasu Hospital, Japan2）; Juntendo University Hospital, Japan3）; Saitama Medical Center, Japan4）; Community Hospital Koga Hospital, Japan5）; Shimane University Hospital, Japan6）; Osaka Medical College Hospital, Japan7）; Gunma University Hospital, Japan8）; Tomakomai City Hospital, Japan9）; National Hospital Organization Disaster Medical Center, Japan10）; Saga University Hospital, Japan11）; BioCryst Pharmaceuticals, USA12）; Hiroshima University, Japan13） PE14-14 Predictors of SLE flare-up and premature delivery in pregnancy Chun Hua Liao1）, Li-Chieh Wang1）, Song-Chou Hsieh2）, Bor-Luen Chiang1） Department of Pediatrics, National Taiwan University Children’s Hospital, Taiwan1）; Department of Internal Medicine, National Taiwan University Hospital, Taiwan2） PE14-15 Allergic disorders in Immunoglobulin G4-related diseases (IgG4-RD) Sayaka Tsuzuki, Keigo Setoguchi Department of Systemic Immunological Disease, Tokyo Metropolitan Cancer and Disease Center Komagome Hospital, Japan PE14-16 Diagnostic criteria for proteasome-associated autoinflammatory syndromes (PRAASs) including Nakajo-Nishimura syndrome, JMP syndrome and CANDLE syndrome Nobuo Kanazawa1）, Hiroaki Ida2）, Noriko Kinjo3）, Tomoaki Ishikawa4）, Ryuta Nishikomori5） Department of Dermatology, Wakayama Medical University, Japan1）; Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University Faculty of Medicine, Japan2）; Department of Pediatrics, University of the Ryukyus Graduate School of Medicine, Japan3）; Department of Pediatrics, Nara Medical University, Japan4）; Department of Pediatrics, Kurume University Faculty of Medicine, Japan5） PE14-17 The clinical effects of mepolizumab in patients with eosinophilic granulomatosis with polyangiitis Session Poster Yasuhiro Hasegawa, Yoshiyuki Arinuma, Kunihiro Yamaoka Department of Rheumatology and Infectious Diseases, Kitasato University, Japan

Poster Session 15

Drug hypersensitivity PE15-1 First recombinant factor IX extended-infusion desensitization protocol in Mexico and Latin-America Raul Alberto Montero Pediatric Allergy & Immunology, Instituto Nacional de Pediatría, Mexico PE15-2 Perforating folliculitis triggered by bevacizumab administration Ayano Maruyama, Risa Tamagawa-Mineoka, Koji Masuda, Norito Katoh Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan PE15-3 Successful oxaliplatin desensitization protocol Ligia L Carrasco1）, Sandra N González Díaz2）, Cindy E De Lira Quezada2）, Rosalaura V Villarreal González2） Department of Allergy and Immunology, University Hospital “Dr José Eleuterio González”, Mexico1）; Regional Center of Allergy and Clinical Immunology, University Hospital “Dr José Eleuterio González”, Mexico2） PE15-4 Two cases of severe drug hypersensitivity Hideki Yoshikawa, Shoto Takemoto, Masaki Kusuda, Taisuke Eguchi Department of Pediatrics, Kirishima Medical Center, Japan PE15-5 Tosufloxacin-induced acute generalized exanthematouspustulosis confirmed by a drug-induced lymphocytestimulation test Takahiro Mizuta1）, Aya Tanaka2） Sakai City Medical Center, Japan1）; Department of Dermatology, Sakai City Medical Center, Japan2） PE15-6 Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms triggered by lenalidomide Shin-Ichi Osada1,2）, Takahiko Sato1） Department of Dermatology, Akita University Graduate School of Medicine, Japan1）; Department of Dermatology, Nippon Medical School Tama Nagayama Hospital, Japan2） 504

PE15-7 A new desensitization protocol in a case of acyclovir hypersensitivity in a child Teresa Garriga-Baraut Department of Pneumology, Allergy and Cystic Fibrosis Pediatric Allergy Unit, Spain PE15-8 A (BP) case in an adult with dipeptidyl peptidase-4 inhibitors (DPP4i) hypersensitivity Shinichiro M Koga1）, Yu Noguchi1）, Takayuki Kajii2）, Hideyuki Ujiie3） Department of Medicine, Tokyo Metropolitan Police Hospital, Japan1）; Department of Dermatology, Tokyo Metropolitan Police Hospital, Japan2）; Department of Dermatology, Hokkaido University School of Medicine, Japan3） PE15-9 Respiratory complications of Stevens-Johnson syndrome (SJS): 3 cases of SJS-induced obstructive bronchiolitis Yurie Seto1）, Yoshiko Kaneko1）, Chie Sotozono2）, Mayumi Ueta2）, Satoshi Sato3）, Hiroshi Date4）, Akihiko Yoshizawa5）, Takayuki Shimamoto1）, Masahiro Iwasaku1）, Tadaaki Yamada1）, Junji Uchino1）, Nobuyuki Hizawa6）, Koichi Takayama1） Department of Pulmonary Medicine, Kyoto Prefectural University of Medicine, Japan1）; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan2）; Division of Infectious Diseases and Immunology, Saitama Children’s Medical Center, Japan3）; Department of Thoracic Surgery, Kyoto University, Japan4）; Center for Anatomical, Pathological and Forensic Medical Reserarches, Kyoto University, Japan5）; Department of Pulmonary Medicine, Tsukuba University, Japan6） PE15-10 Peripheral blood lymphocyte decrease at the onset of drug eruption Daiki Nomura1）, Shigeko Inokuma1）, Satoshi Miike1）, Manami Kato1）, Jun Kanemura1）, Takahide Akimoto2） Department of Allergy and Rheumatic Diseases, Chiba Central Medical Center, Japan1）; Department of Dermatology, Chiba Central Medical Center, Japan2） PE15-11 Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Nurul Iman Nilam Sari, Endah Citraresmi Department of Child Health, Harapan Kita Women and Children Hospital, Indonesia PE15-12 Desensitization protocol to paclitaxel: the importance of proving the ideal treatment in a patient with anaphylaxis and breast cancer Cindy E De Lira-Quezada1,2）, Sandra N González-Díaz1,2）, Rosalaura V Villarreal-González1,2）, Rodrigo A De la Cruz-Cruz1,2） Regional Center of Allergy and Clinical Immunology University Hospital “Dr José Eleuterio González”, Mexico1）; Autonomous University of Nuevo Leon, Mexico2） PE15-13 Rituximab desensitization in acute lymphoblastic leukemia pediatric patient with severe anaphylaxis Rosalaura Villarreal-Gonzalez1）, Sandra Gonzalez-Diaz2）, Cindy De Lira-Quezada2）, Ligia Carrasco-Diaz2）, Natalhie Acuna-Ortega2） Regional Center of Allergy and Clinical Immunology, University Hospital, Faculty of Medicine, Autonomous University of Nuevo Autonomous University of Nuevo Leon, Mexico1）; Allergy and Clinical Immunology, University Hospital, Mexico2） PE15-14 Higher occurrence of multiple syndrome to first-line anti-tuberculosis drugs Young-Il Koh, Da Woon Sim, Ji Eun Yu, Hye Su You Department of Internal Medicine, Chonnam National University Medical School, Republic of Korea PE15-15 Beta-lactam allergy: a real practice in a regional hospital Hyerim Kim1）, Jaechun Lee1）, Sejin Kim2） Jeju National University Hospital, Republic of Korea1）; Department of Internal Medicine, Jeju National University Hospital, Republic of Korea2） PE15-16 Biological treatments in allergy: a worldwide survey on prescription and management of hypersensitivity reactions Leyla Barakat1）, Luciana Kase Tanno1,2,3） Centre Hospitalier Universitaire de Montpellier, Hôpital Arnaud-de-Villeneuve, Département de Pneumologie et Addictologie, University of Montpellier, France1）; Sorbonne Université, INSERM UMR-S 1136, IPLESP, Equipe EPAR, 7513, France2）; WHO Collaborating Centre on Scientific Classification Support, France3）

Poster Session 16

Education and allied health PE16-1 What is the expected role of a pediatric allergy-pulmonologist in a medium-sized general hospital? a descriptive analysis of the 5

otrSession Poster years’ consultation Dong In Suh1）, Jun-Hyuk Song2） Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Hospital, Republic of Korea1）; Department of Pediatrics, Myongji Hospital, Republic of Korea2） PE16-2 Prevalence and predictors of incorrect use of inhaler device in patients with obstructive lung diseases Hiroyuki Tamiya1）, Akihisa Mitani1）, Toshihide Abe2）, Kousuke Eitoku2）, Maiko Yamada2）, Kazuo Takayama2）, Yoshiyuki Ohno2）, Yukie Nagase2）, Goh Tanaka1）, Hiroshi Suzuki2）, Takahide Nagase1） The Department of Respiratory Medicine, the University of Tokyo Hospital, Japan1）; The Department of Pharmacy, the University of Tokyo Hospital, Japan2） PE16-3 Characterization of airborne fungi spores present in two hospitals in kabala district- uganda Adeyinka Odebode, Gerald Niwamanya Department of Environment, Uganda PE16-4 Efficacy of adrenaline auto-injector diary Taku Oishi1）, Kouhei Hagino2）, Hajime Kuroiwa3）, Mikiya Fujieda1） Department of Pediatrics, Kochi Medical School, Kochi University, Japan1）; Department of Pediatrics, Kochi Prefectural Hata Kenmin Hospital, Japan2）; Integrated Center for Advanced Medical Technologies, Kochi Medical School, Japan3） PE16-5 Changes of prehospital management of anaphylaxis in pediatric patients between 2018 and 2013 Chikako Motomura, Takeshi Oki, Masatoshi Wakatsuki, Toshiaki Kawano, Koki Okabe, Takehito Fukushima, Daisuke Yasunari, Hiroshi Mastuzaki, Mihoko Iwata, Yoko Murakami, Naohiko Taba, Satoshi Honjo, Hiroshi Odajima Department of Pediatrics, National Hospital Organization, Fukuoka National Hospital, Japan PE16-6 An educational workshop to expose clinical research investigators and related personnel to research ethics Hiroaki Yanagawa1）, Kenshi Takechi1）, Masayuki Chuma1）, Yasutaka Sato1）, Chikako Kane1）, Satoshi Sakaguchi1）, Kaori Doi2）, Yusuke Inoue3）, Kenji Matsui4） Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital, Japan1）; Department of Research Ethics & Bioethics, National Cerebral and Cardiovascular Center Research Institute, Japan2）; Department of Public Policy, Institute of Medical Science, the University of Tokyo, Japan3）; Division of Bioethics and Healthcare Law, National Cancer Center Japan, Japan4） 505

PE16-7 “Breathe power go!” ; an easy and fun game to identify obstructive pulmonary disorder Yurie Namoto1）, Tetsuya Oguma1,5,6）, Makoto Yamazaki1,3）, Mayu Aizawa1,4）, Daiki Hira2,5）, Masahumi Yamaguchi6）, Emiko Ogawa6）, Yuko Komase5）, Yasutaka Nakano6） Department of Respiratory Medicine, Oguma Family Clinic, Japan1）; Faculty of Pharmaceutical Sciences, Ritsumeikan University, Japan2）; Faculty of Medicine, Shiga Medical University, Japan3）; Faculty of Life Sciences, Ritsumeikan University, Japan4）; Association of Inhalation therapists, Japan5）; Department of Respiratory Medicine, Shiga Medical University, Japan6） PE16-8 The pack cooking that helps food allergic patients at the time of disaster, focused on weaning foods Naoko Okishima, Saki Ogura, Kyoka Nishimaki, Haruna Nakayma, Kana Miyahara Department of Health and Nutritional Science, Matsumoto University, Japan PE16-9 Interview with adolescent food allergy patients and their caregivers about self-management Akiko Yamaide1）, Yurika Yoshino2）, Hironori Sato1）, Yuzaburo Inoue1）, Naoki Shimojo3）, Akira Hoshioka1） Department of Allergy and Rheumatology, Chiba Children’s Hospital, Japan1）; Department of Nursing, Chiba Children’s Hospital, Japan2）; Department of Pediatrics, Graduate School of Medicine, Chiba University, Japan3） PE16-10 The actual condition of bronchial asthma patients in Japanese students Takanori Imai Department of Pediatrics, Showa University School of Medicine, Japan PE16-11 Changes in self-care education for children with allergic diseases by medical staff in Japan: a report from a nationwide survey Masami Narita1）, Ikuyo Masuko2）, Akira Akasawa Iino2） Division of Allergy, Tokyo Metropolitan Children’s Medical Center, Japan1）; Nasunogahara Clinic, Japan2） PE16-12 Severe asthma in children in Japan: a single-center, retrospective chart review study Nagatoshi Sagara, Ryohei Suzuki, Akiko Aota, Kennichi Akashi, Toshio Kastunuma Department of Pediatrics, Daisan Hospital, The Jikei University School of Medicine, Japan PE16-13 Attitude survey of medical professionals for pregnancy with asthma Yuko Komase1）, Naoko Uehara2）, Takahiro Tsuburai1）, Baku Ohyama1） Department of Respiratory Internal Medicine, St Marianna University, School of Medicine, Yokohama-City Seibu Hospital, Japan1）; Department of Allergology, Yokohama City Minato Red Cross Hospital, Japan2） PE16-14 Accelerometer-equipped external attachments to assist effective inhalation techniques Miyuki Nishie1）, Katsunori Masaki1）, Hideo Nakada2）, Taiko Ezaki1）, Keeya Sunata1）, Yuto Akiyama1）, Risa Watanabe1）, Misato Kuwae1）, Shinichi Okuzumi1）, Takae Tanosaki1）, Hiroki Kabata1）, Nobuyuki Togashi4）, Tomoyuki Shimono4,5）, Tohru Aomori2,3）, Koichi Fukunaga1） Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Japan1）; Division of Hospital Pharmacy Science, Keio University Faculty of Pharmacy, Japan2）; Department of Hospital Pharmacy, Keio University Hospital, Japan3）; Kanagawa Institute of Industrial Science and Technology, Japan4）; Faculty of Engineering, Yokohama National University, Japan5） PE16-15 Evaluation of educational program at NPO, EPAREC (Expert Patient in Respiratory Care) employing ABMA-C (Asthma Belief and Medication Adherence) questionnaire that reflect adherence Michiko Haida1,4）, Bruce Bender2）, Katsutoshi Ogawa3,4）, Tamotsu Kiyohara4）, Kenzou Nakao4）, Takahiro Inoue1,4）, Akihiko Hashiguchi5） Hanzoumon Hospital, Japan1）; National Jewish Health, USA2）; Amica Life-science, Japan3）; EPAREC (Expert Patient in Respiratory Care), Japan4）; Biomedical Laboratory, Japan5） PE16-16 Inhalation instruction with wearing masks under the Novel Coronavirus Disease 2019 (COVID-19) spread Makoto Yamasaki1,2）, Tetsuya Oguma1,2）, Yurie Namoto1,3）, Mayu Aizawa1,4）, Shizuka Hattori5）, Masahumi Yamaguchi2）, Emiko Ogawa2）, Yasutaka Nakano2） Oguma Family Clinic, Japan1）; Division of Respiratory Medicine, Department of Medicine, Shiga University of Medical Science, Japan2）; Faculty of Pharmaceutical Science, Ritsumeikan University, Japan3）; Faculty of Life Science, Ritsumeikan University, Japan4）; Usagi Pharmacy Minami-Kusatsu Division, Japan5） PE16-17 Attempt of online inhalation workshop during COVID19 epidemic: comparison withface-to-face workshop Tetsuya Ueda1,2）, Akira Shiraki2）, Chie Yoshimura2）, Yuko Komase2）, Tetsuya Oguma2）, Takeo Horie2）, Naoko Uehara2）, Yasuyuki Momose2） Department of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Japan1）; Non Profit Organization Association of Inhalation Therapists, Japan2） otrSession Poster

Poster Session 17

Food allergy-allergen and mechanisms PE17-1 ImmunoCAP ISAC in food allergy diagnosis: a systematic review Agnieszka Dobrzynska, Jose-Maria Maesa, Elena Baños-Alvarez, Rebeca Isabel-Gomez, Juan-Antonio Blasco-Amaro Health Technolgy Assessment Agency of Andalusia, Spain PE17-2 Clinical cross-reactivity to quail’s egg in patients with hen’s egg allergy Masatoshi Mitomori1）, Mari Takei2）, Kinji Tada2）, Makoto Nishino1）, Noriyuki Yanagida1）, Sakura Sato2）, Motohiro Ebisawa2） Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan1）; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2） PE17-3 Cross-allergenicity between hen’s egg and quail’s egg in patients allergic to hen’s egg Mari Takei1）, Masatoshi Mitomori2）, Kinji Tada1）, Noriyuki Yanagida2）, Sakura Sato1）, Akemi Saito1）, Motohiro Ebisawa1） Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan2） PE17-4 Identification and characterization of perilla seed allergy in Korean children: clinical and immunological profiles Kyunguk Jeong1）, So-Yeon Lee2）, Se-Ah Jeon1）, Purevsan Gantulga1）, Jin Young Nam1）, Soo-Jong Hong2）, Sooyoung Lee1） Department of Pediatrics, Ajou University School of Medicine, Republic of Korea1）; Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, University of Ulsan College of Medicine, Republic of Korea2） PE17-5 Evaluation of multiple specific IgEs screening system DropScreenⓇ using a microarrayed allergen biochip Yoshihiro Ito1）, Sei Obuse1）, Sakura Sato2）, Motohiro Ebisawa2） Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, Japan1）; National Hospital Organization Sagamihara National Hospital, Japan2） PE17-6 Comparison of IgE sensitization profile in shrimp allergic subjects between Hong Kong and Thailand CYY Wai1）, ASY Leung1）, P Vichyanon2）, P Pacharn3）, NYH Leung1）,KXu1）, CY Lam1）,TFLeung1） Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong1）; Samitivej Allergy Institute (SAI), Samitivej Thonburi Hospital, Thailand2）; Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Thailand3） 506

PE17-7 IgE sensitization profile of fish allergic children in Hong Kong Nicki YH Leung, Agnes SY Leung, Christine YY Wai, Jiaying Xu, Cheuk Yin Lam, Gary WK Wong, Ting Fan Leung Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong PE17-8 Cytokine profiles during oral food challenges for diagnosis of food protein-induced enterocolitis syndrome to egg yolk Nobuko Akamatsu, Takashi Yamazaki, Yasuyo Kashiwagi, Takeaki Sasamoto, Masako Chiyotanda, Taro Miura, Ryuhei Nagao, Hisashi Kawashima Department of Pediatrics and Adolescent Medicine, Tokyo Medical University Hospital, Japan PE17-9 Tropomyosin is a major antigen in childhood-onset shrimp allergy but a minor antigen in adults Masashi Nakamura1,6）, Akiko Yagami2,7）, Yuri Takaoka3）, Nayu Sato1,6）, Satoshi Ohno4）, Kayoko Suzuki2,7）, Naoshi Shimojo1,6）, Kyoko Futamura2,7）, Yasuto Kondo5,7）, Yuji Aoki1,6）, Makoto Kameda3）, Kayoko Matsunaga1,2） Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Japan1）; Department of Allergology, Fujita Health University School of Medicine, Japan2）; Department of Pediatrics, Osaka Habikino Medical Center, Japan3）; Faculty of Engineering, Gifu University, Japan4）; Department of Pediatrics, Fujita Health University School of Medicine, Japan5）; General Research and Development Institute, Hoyu Co., Ltd., Japan6）; Fujita Health University General Allergy Center, Japan7） PE17-10 Clinical correlation of antigen-specific IgE/IgG4 ratio in milk protein allergy Chun-Min Kang1,2）, Kuan-Hua Chu1）,Ya-ChiaoHu1）, Hsin-Hui Yu1）, Jyh-Hong Lee1）, Li-Chieh Wang1）, Yu-Tsan Lin1）, Yao-Hsu Yang1）, Bor-Luen Chiang1） Department of Pediatrics, National Taiwan University Hospital, Taiwan1）; Department of Laboratory Medicine, National Taiwan University Hospital, Taiwan2） PE17-11 THEMIS affects Th2 immune response in OVA-induced food allergy model Mi Na Kim, Eun Gyul Kim, Jung Yeon Hong, Kyung Won Kim, Myung Hyun Sohn Department of Pediatrics and Institute of Allergy, Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Republic of Korea PE17-12 Thermal effect on hen’s egg white and quail egg white proteins and analysis of cross-reactivity in young children Jeongmin Lee1）, Purevsan Gantulga2）, Kyunguk Jeong2）, Se-ah Jeon2）, Sooyoung Lee2） Department of Pediatrics, Yonsei University Wonju College of Medicine, Republic of Korea1）; Department of Pediatrics, Ajou University School of Medicine, Republic of Korea2） PE17-13 Hemocyanin is not a major allergen in a cohort of probable shrimp-allergic Chinese children Cheuk Yin Lam, Sze-Yin Agnes Leung, Yee Yan Christine Wai, Yat Hin Nicki Leung, Wing Kin Gary Wong, Ting Fan Leung Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong PE17-14 Structure of sensitization to food extracts and molecules in Dnipro (Ukraine) Viktoriia Voloshkina, Eugenia Dytyatkovska, Katerina Gashynova Occupational Diseases and Clinical Immunology, SE “Dnipropetrovsk Medical Academy Ministry of Health of Ukraine”, Ukraine PE17-15 Two commercial Gal d 1 specific IgE assays show major differences in specificity and accuracy, with potential clinical implications Shinya Yoshihara, Motoko Nakayama, Yosihide Terashi, Koryo Nakayama, Manabu Miyamoto, Yusuke Ando, Yuji Fujita, Masaya Kato, Shigemi Yoshihara Department of Pediatrics, Dokkyo Medical University, Japan PE17-16 Does topical anesthesia affect the interpretation of diagnostic skin testing to food allergens in children Nattasasi Suchamalawong1）, Naruporn Tosirisuk2）, Pantipa Chatchatee2）, Narissara Suratannon2） Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thailand1）; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thailand2） PE17-17 Effects of reducing the amounts of food allergens in the home environment on allergen sensitization Fumiya Yamaide1）, Chikao Maeda2）, Aya Yoshikawa2）, Masayuki Mikuriya2）, Noriko Sato1）, Taiji Nakano1）, Yoshikuni Katsura2）, Masahiro Imanishi2）, Naoki Shimojo1） Department of Pediatrics, Graduate School of Medicine, Chiba University, Japan1）; Duskin Co., Ltd. R&D, Japan2） PE17-18 Probability curve for infant hen’s egg allergy Yutaka Takemura1）, Norihiro Inoue1,2）, Tomoyuki Arima1）, Hiroki Masumi1）, Koji Yamasaki1）, Megumi Nagai1）, Keisuke Sugimoto1） otrSession Poster Department of Pediatrics, Kindai Hospital, Japan1）; Department of Pediatrics, Osaka-Minami Hospital, Japan2） PE17-19 Evaluation of the allergenicity and induction ability for oral tolerance of ω5-gliadin-deficient Hokushin wheat (1BS-18) in a rat model Yukinori Yamada1）, Tomoharu Yokooji1,2）, Naoki Ninomiya1）, Takanori Taogoshi1）, Eishin Morita3）, Hiroaki Matsuo1） Department of Pharmaceutical Services, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan1）; Department of Frontier Science for Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan2）; Department of Dermatology, Faculty of Medicine, Shimane University, Japan3）

Poster Session 18

Food allergy-clinical aspects 1 PE18-1 Red meat allergy: clinical characteristics of 5 cases in Jeju, Korea Sejin Kim, Jaechun Lee, Ara Ko Department of Internal Medicine, Jeju National University School of Medicine, Republic of Korea PE18-2 Combinations of anaphylaxis symptoms in oral food challenges Naoto Otake1）, Tomoyuki Asaumi1）, Noriyuki Yanagida1）, Sakura Sato2）, Motohiro Ebisawa2） Department of Pediatric, National Hospital Organization, Sagamihara National Hospital, Japan1）; Department of Allergy, Clinical Research Center for Allergology and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2） PE18-3 Predictor of the buckwheat challenge test results: a retrospective observational study in Japan Naoki Kajita, Koichi Yoshida, Shoko Yokoyama, Keiko Hirao, Masami Narita Department of Allergy, Tokyo Metropolitan Children’s Medical Center Japan PE18-4 Analysis of the appropriate timing to introduce egg white to children with egg yolk triggered food protein-induced enterocolitis syndrome Yohei Watanabe, Hideyuki Sakai, Satoru Kumaki Department of Pediatrics, Sendai Medical Center, Japan 507

PE18-5 Prediction of severe peach allergy reaction combining peach allergen component specific IgE antibodies in Japanese children and adolescents Yusuke Ando, Yoshihide Terashi, Shinya Yoshihara, Koryo Nakayama, Manabu Miyamoto, Masaya Kato, Yuji Fujita, Motoko Nakayama, Hironobu Fukuda, Shigemi Yoshihara Department of Pediatrics, Dokkyo Medical University, Japan PE18-6 Risk factors for moderate to severe allergic reactions in oral food challenges Kazuki Sato1）, Azusa Nakamura1）, Shuichi Suzuki1）, Hiroko Watanabe1）, Minako Tomiita1）, Yohei Kawasaki2）, Yuki Shiko2） Department of Pediatrics, Shimoshizu National Hospital, Japan1）; Clinical Research Center, Chiba University Hospital, Japan2） PE18-7 Predictive factors of walnut allergy: a retrospective observational study in Japan Ayano Nishimoto, Masami Narita, Koichi Yoshida, Keiko Hirao, Shoko Yokoyama Department of Allergy, Tokyo Metropolitan Children’s Medical Center, Japan PE18-8 Diagnosis of bean sprout allergy with anaphylaxis shock Yasuhiko Koga1）, Masakiyo Yatomi1）, Haruka Aoki-Saito1）, Takeshi Hisada2） Department of Respiratory Medicine, Gunma University Graduate School of Medicine, Japan1）; Gunma University Graduate School of Health Sciences, Japan2） PE18-9 Basophil activation test for milk and egg allergy in children with atopic dermatitis Yoon Hee Kim1）, Young Suh Kim1）, Younhee Park2）, Soo Yeon Kim1）, Hye Yung Yum3）, Kyung Won Kim1）, Myung Hyun Sohn1） Department of Pediatrics, Yonsei University College of Medicine, Republic of Korea1）; Department of Laboratory Medicine, Yonsei University College of Medicine, Republic of Korea2）; Department of Pediatrics, Seoul Medical Center, Republic of Korea3） PE18-10 Factors associated with passing small dose milk oral food challenges Hiroaki Taniguchi1,2）, Satoshi Hirase1,2）, Masashi Hara1,2）, Yukari Koshiba1,2）, Mizuka Kaji1,2）, Kumiko Itani1,2）, Kanako Nakano1,2）, Kunitaka Ota1,2）, Motohiro Ebisawa3） Department of Pediatrics, Konan Medical Center, Japan1）; Department of Pediatrics, Rokko Island Hospital, Japan2）; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan3） PE18-11 Clinical manifestations and safety of oral food challenge using boiled egg yolk Kei Uneoka1）, Satoshi Horino1）, Masato Nihei1）, Haruka Aki1）, Hiroshi Kitazawa1,2）, Katsushi Miura1） Department of Allergy, Miyagi Children’s Hospital, Japan1）; Division of Pediatrics, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan2） PE18-12 Oral food challenges for the diagnosis of food allergy, real life experience from Mexico Joaquin A Pimentel, Elsy M Navarrete, Blanca E Del Rio, Enrique E Castelán Department of Allergy and Immunology, Hospital Infantil de México, Mexico PE18-13 A feasibility study of oral-food-challenge in non-IgE-mediated gastrointestinal food allergies in infants by long-term and incremental methods Koji Nishimura, Miori Sato, Hiroya Ogita, Tomoyuki Kiguchi, Yoshitsune Miyagi, Yusuke Inuzuka, Kenji Toyokuni, Makoto Irahara, Fumi Ishikawa, Sigenori Kabashimra, Kiwako Yamamoto Hanada, Tatsuki Fukuie, Ichiro Nomura, Yukihiro Ohya Allergy Center, National Center for Child Health and Development, Japan PE18-14 Prediction of negative results of oral food challenges by antigen-specific IgE values Daisuke Takeishi, Yuji Iimura, Mariko Mikami, Ichiro Matsumoto, Akira Kono Department of Pediatrics, Jouhoku Hospital, Japan PE18-15 Effect of frequency of hen’s egg ingestion on the succeeding oral food challenge test Toshiyuki Takagi, Yuki Okada, Kosei Yamashita, Chihiro Kunigami, Mayu Maeda, Toshinori Nakamura, Taro Kamiya, Takanori Imai, Katsumi Mizuno Department of Pediatrics, Showa University School of Medicine, Japan PE18-16 Evaluation of risk factors and safety of oral food challenges of a very small portion of an egg Aiko Honda, Mayu Maeda, Yuki Okada, Toshinori Nakamura, Taro Kamiya, Takanori Imai Department of Pediatrics, Showa University School of Medicine, Japan PE18-17 Risk factors for multiple-nut allergies in patients with peanut allergy otrSession Poster Kazutaka Nogami, Mayumi Matsunaga, Yamada Shingo, Miyuki Hoshi, Kana Hamada, Keigo Kainuma, Mizuho Nagao, Takao Fujisawa Allergy Center, National Hospital Organization Mie National Hospital, Japan

Poster Session 19

Food allergy-clinical aspects 2 PE19-1 Comparison of sensitization to food allergens among children and adolescents with migraine and tension headache Marzieh Heidarzadeh Arani1）, Ahmad Talebiyan1）, Alireza Ghannadian1）, Hossein Akbari2） Pediatric -Kashan University of Medical Science, Iran1）; Biostatistics, Kashan University of Medical science, Iran2） PE19-2 Eosinophilic gastroenteritis treated with targeted two-elimination diet in a child Masaaki Doi1）, Aya Sasaki1）, Akiko Masaki1）, Ryouta Yoshida1）, Kumiko Takagi1）, Yasutaka Matsubara1）, Yasuko Furuichi1）, Shinnosuke Tsuji2）, Tomoko Takano2） Department of Pediatrics, Higashiosaka City Medical Center, Japan1）; Department of Pediatrics, Osaka General Medical Center, Japan2） PE19-3 Analysis of pollen-specific IgE levels that induce pollenfood allergy syndrome in children Masaya Kato, Shinya Yoshihara, Yoshihide Terashi, Koryo Nakayama, Manabu Miyamoto, Yusuke Ando, Yuji Fujita, Motoko Nakayama, Shigemi Yoshihara Department of Pediatrics, Dokkyo Medical University, Japan PE19-4 Integrated analysis of genomics and metabolomics in childhood food allergy resolution Haerin Jang1,2,3）, Mina Kim1,2,3）, Jung Yeon Hong1,2,3）, Yoon Hee Kim1,2,3）, Myung Hyun Sohn1,2,3）, Kyung Won Kim1,2,3） Department of Pediatrics, Severance Hospital, Republic of Korea1）; Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Republic of Korea2）; Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Republic of Korea3） PE19-5 Retrospective review of food allergic children in a tertiary allergy centre in Hong Kong Ting Fan Leung, Agnes Sze Yin Leung, Noelle Anne Ngai Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong 508

PE19-6 Major triggers of food allergy and food-induced anaphylaxis in recent 10 years in Korea: a single hospital retrospective study including all ages Eunjoo Lee1）, Sooyoung Lee2）, Kyunguk Jeong2）, Yoo-Seob Shin3）, Youngsoo Lee3）, Young-Min Ye3） Department of Pediatrics, Inje University Haeundae Paik Hospital, Republic of Korea1）; Department of Pediatrics, Ajou University School of Medicine, Republic of Korea2）; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Republic of Korea3） PE19-7 Prevalence of food allergy in staff members of Fukuoka National Hospital, Japan Akiko Sugiyama1,2,3）, Reiko Kishikawa1,3）, Koki Okabe1,3）, Takehito Fukushima1,3）, Nanae Kimura2）, Kaoru Kojima3）, Makiko Oda3）, Satoshi Honjo3）, Makoto Yoshida3）, Mai Honda4）, Hiroyuki Murota4）, Masutaka Furue5） Department of Allergy, Fukuoka National Hospital, Japan1）; Department of Dermatology, Fukuoka National Hospital, Japan2）; Department of Clinical Research, Fukuoka National Hospital, Japan3）; Department of Dermatology, Nagasaki University Hospital, Japan4）; Department of Dermatology, Kyushu University Hospital, Japan5） PE19-8 Incidence of allergic reactions in elementary, junior high, and high schools in from 2015 to 2019 Takaharu Inoue1,2）, Hisako Yagi1）, Satoshi Yamada1）, Koichiro Sato1）, Yutaka Nishida1）, Hirokazu Arakawa1）, Takumi Takizawa1） Department of Pediatrics, Gunma University Graduate School of Medicine, Japan1）; Department of Pediatrics, Public Tomioka General Hospital, Japan2） PE19-9 Sensitization to gibberellin-regulated protein in hinoki cypress pollen is associated with severity of peach allergy Nobuyuki Maruyama1）, Sakura Sato2）, Kyotan Sho1）, Cerrone Cabanos1）, Motohiro Ebisawa2） Graduate School of Agriculture, Kyoto University, Japan1）; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2） PE19-10 Increase in food protein-induced enterocolitis syndrome caused by solids: a case study Daisuke Shigeta1）, Takayuki Nakazawa1）, Tatsuya Yoda1）, Machiko Hosoya1）, Hisako Yagi2）, Takumi Takizawa2） Department of Pediatrics, Saku Central Hospital Advanced Care Center, Japan1）; Department of Pediatrics, Gunma University Hospital, Japan2） PE19-11 Egg sensitization in children with atopic dermatitis: correlation with parental concerns Colin Tan, Hua Yen Ling, Hwee Chyen Lee, Cheryl Lie, Uma Alagappan Dermatology Service, KK Women’s and Children’s Hospital, Singapore PE19-12 Progression to esophageal eosinophilia in patients with suspected eosinophilic esophagitis or congenital esophageal stenosis Mariko Shimizu1）, Yuichi Kama1,2）, Akihiko Shimizu1）, Shigeru Nomura1）, Akira Nishi3）, Masahiko Kato1,2）, Yoshiyuki Yamada1） Division of Allergy and Immunology, Gunma Children’s Medical Center, Japan1）; Department of Pediatrics, Tokai University School of Medicine, Japan2）; Division of Surgery, Gunma Children’s Medical Center, Japan3） PE19-13 Pollen-food allergy syndrome in Japanese children with allergic diseases: a single center study Azusa Nakamura, Syuichi Suzuki, Kazuki Sato, Minako Tomiita Department of Pediatrics, National Hospital Organization National Shimoshizu Hospital, Japan PE19-14 Sensitization to hen’s egg during early infancy in a cohort study of Japanese infants with eczema Mari Takei1）, Noriyuki Yanagida2）, Sakura Sato1）, Yohei Watanabe3）, Shigenori Kobayashi3）, Hideo Kaneko3）, Michimasa Fujiwara3）, Wakako Shinahara4）, Hiroshi Kido4）, Motohiro Ebisawa1） Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan2）; Immune Abnormal Network Group, National Hospital Organization, Japan3）; Division of Enzyme Chemistry, Institute for Enzyme Research, Tokushima University, Japan4） PE19-15 Characteristics of pollen-related food allergy based on individual pollen allergy profiles in the Chinese population JunDa Li, Jia Yin Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China PE19-16 An epidemiologic study of oral allergy syndrome and pollen allergy in Japanese university students Nobue Takamatsu1）, Masaru Kubota2）, Izumi Hayashidera2）, Kumiko Nakai3）, Yukie Higashiyama4）, Takashi Kusunoki2） Beppu University, Japan1）; Ryukoku University, Japan2）; Hagoromo University of International Studies, Japan3）; Aichi Shukutoku University, Japan4） PE19-17 Changes in the clinical presentation of infants’ food allergies at first onset and the impact of early food introduction in a 9-year period Kiyotake Ogura1）, Kyohei Takahashi1）, Noriyuki Yanagida1）, Sakura Sato2）, Motohiro Ebisawa2） Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan1）; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2） otrSession Poster

Poster Session 20

Food allergy-clinical aspects 3 PE20-1 Three-year prognosis of fish allergy in children Naoko Fusayasu1）, Tomoyuki Asaumi1）, Hiroaki Taniguchi3）, Noriyuki Yanagida1）, Sakura Sato2）, Motohiro Ebisawa2） Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2）; Department of Pediatrics, Konan Medical Center, Japan3） PE20-2 An evaluation of the effects of Kakkonto in combination with dietary advice in children with food allergies through a non-randomized controlled trial Taisuke Kato1）, Yasunori Ito1）, Takeshi Yamamoto2）, Muneyuki Shimizu1）,YokoAdachi1）, Makoto Kadowaki2）, Yuichi Adachi1） Department of Pediatrics, Faculty of Medicine, University of Toyama, Japan1）; Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Japan2） PE20-3 Efficacy of bronchodilators for moderate respiratory symptoms in oral food challenges Toshinori Kitatsu1）, Naoko Fusayasu1）, Tomoyuki Asaumi1）, Noriyuki Yanagida1）, Sakura Sato2）, Motohiro Ebisawa2） Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2） PE20-4 Examination of a single administration of 2g of boiled egg white to infants sensitized to egg white in a first-time oral food challenge Koji Yamasaki1）, Yutaka Takemura1,2）, Tomoyuki Arima1）, Hiroki Masumi2）, Megumi Nagai1）, Norihiro Inoue3）, Keisuke Sugimoto1） Department of Pediatrics, Kindai University Hospital, Japan1）; Department of Pediatrics, Kaizuka City Hospital, Japan2）; Department of Pediatrics, National Hospital Organization Osaka Minami Medical Center, Japan3） PE20-5 Effect of the change in specific immunoglobulin E levels on the result of oral food challenge for patients with egg allergy: a retrospective observational study Masaru Kawamura, Moeri Tsuji, Kota Ikari, Takuya Oda, Junichiro Tezuka Department of Allergy and Pulmonology, Fukuoka Children’s Hospital, Japan 509

PE20-6 The problems with allergen-free hospital food service Sanae Kishida1）, Sachiko Kaburagi1）, Kumiko Morita1）, Tomo Ishii2）, Masayuki Akashi1） Department of Pediatrics, Keio University Hospital, Japan1）; Department of Pediatrics, Tochigi Medical Center, Japan2） PE20-7 The distribution of Mal d 1 protein, apple allergen component, in apples cultivated and consumed in Japan Naoko Okishima, Chiyumi Suzuki, Takumi Fukuda, Shiho Nakayama, Masami Nitta Department of Health and Nutritional Science, Matsumoto University, Japan PE20-8 Determinants of parental burden among Hong Kong children with adverse food reactions Ming Yan Rebecca Li, Agnes Sze Yin Leung, Gary Wing Kin Wong, Ting Fan Leung Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong PE20-9 Case report of 9 childhood patients with buckwheat allergy Xiaoyang Wang, Chuanhe Liu Department of Allergy, Capital Institute of Pediatrics, China PE20-10 Wheat allergy in children: 21 cases reports Xiaoyang Wang, Chuanhe Liu, Mingjun Shao, Li Sha, Jing Zhao Department of Allergy, Capital Institute of Pediatrics, China PE20-11 An impaired bone mineral density in children with cow’s milk allergy Komei Ito1）, Tomomi Nakazato1）, Shiro Sugiura1）, Yoshihiro Takasato1）, Teruaki Matsui1）, Katsumasa Kitamura1）, Harue Umemura2） Aichi Children’s Health and Medical Center, Japan1）; Department of Nutrition, Nagoya University of Arts and Sciences, Japan2） PE20-12 Decreased bone mineral density of the school children with IgE-mediated cow’s milk allergy Mika Ogata1）, Nami Hirai1）, Tomoyuki Mizukami1）, Tetsuo Ikeda3）, Soroku Nishiyama2） Department of Pediatrics, National Hospital Organization Kumamoto Medical Center, Japan1）; Faculty of Human Life Science, Department of Nutritional Science, Shokei University, Japan2）; Department of Pediatrics, Jikei Hospital, Japan3） PE20-13 The summary of oral food challenge tests for the past two years at a secondary care hospital in Japan Mikita Yamamoto, Kenji Waki, Yoshio Aragaki Department of Pediatrics, Kurashiki Central Hospital, Japan PE20-14 Safety of low-dose cow’s milk oral food challenges administered in two doses at 60-minute intervals Nana Kojima1）, Makoto Nishino1）, Naoto Otake1）, Toshinori Kitatsu1）, Noriyuki Yanagida1）, Sakura Sato2）, Motohiro Ebisawa2） Depertment of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Allergy, Clinical Research Center for Allergology and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2） PE20-15 Clinical features of Chinese yam allergy in Japanese children Hiroaki Obayashi1,2）, Katsumasa Kitamura2）, Teruaki Matsui2）, Yoshihiro Takasato2）, Shiro Sugiura2）, Komei Ito2） Department of Pediatrics, Matsudo City General Hospital Children’s Medical Centre, Japan1）; Department of Allergy, Aichi Children’s Health and Medical Center, Japan2）

Poster Session 21

Food allergy-Immunotherapy PE21-1 Three-year outcomes of oral immunotherapy using dried egg powder for severe hen’s egg allergy Koki Sasamoto1）, Ken-ichi Nagakura1）, Noriyuki Yanagida1）, Sakura Sato2）, Motohiro Ebisawa2） Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2） PE21-2 Safety of ultralow-dose of antigen oral immunotherapy in pediatric patients with severe peanut allergy: induction, fixed-dose, and escalation phases Kyoko S Nishikage1,2）, Takeharu Yamanaka2） Yokohama Nishikage Clinic:kids and allergies, Japan1）; Department of Biostatistics, School of Medicine, Yokohama City University, Japan2）

PE21-3 Comparison of the efficacies of low-dose and high-dose slow oral immunotherapy for egg allergy Session Poster Yuri Takaoka, Junko Kumon, Tomohiro Yamaguchi, Rumi Ueno, Yuki Tsurinaga, Tamana Nakano, Yohei Fukasawa, Amane Shigekawa, Yukinori Yoshida, Makoto Kameda Department of Pediatrics, Osaka Habikino Medical Center, Japan PE21-4 Low achievement of sustained unresponsiveness in oral immunotherapy for persistent cow’s milk allergy Toshinori Nakamura, Kosei Yamashita, Yuki Okada, Mayu Maeda, Taro Kamiya, Takanori Imai Department of Pediatrics, Showa University School of Medicine, Japan PE21-5 Food allergy and oral immunotherapy affect food preferences Kenji Toyokuni, Kiwako Yamamoto-Hanada, Yoshitsune Miyagi, Hiroya Ogita, Tomoyuki Kiguchi, Yusuke Inuzuka, Koji Nishimura, Fumi Ishikawa, Makoto Irahara, Miori Sato, Mayako Saito-Abe, Yumiko Miyaji, Shigenori Kabashima, Tatsuki Fukuie, Yukihiro Ohya Allergy Center, National Center for Child Health and Development, Japan PE21-6 Long-term quality of life of persistent food allergy patients in post oral immunotherapy Kosei Yamashita, Toshinori Nakamura, Toshiyuki Takagi, Yuki Okada, Mayu Maeda, Taro Kamiya, Takanori Imai, Katsumi Mizuno Department of Pediatrics, Showa University School of Medicine, Japan PE21-7 Effectiveness and safety of rush and slow oral immunotherapy in our facility Tomonori Kadowaki, Yukiko Otsuka, Yuki Okada, Kanako Maruta, Kumiko Miyazaki, Yuko Shimokawa, Koji Tatebayashi, Michinori Funato, Hideo Kaneko Department of Pediatrics, National Hospital Organization Nagara Medical Center, Japan PE21-8 Factors associated with the safety of initials dose of slow low-dose oral immunotherapy Shiro Sugiura, Katsumasa Kitamura, Teruaki Matsui, Yoshihiro Takasato, Komei Ito Department of Allergy, Aichi Children’s Health and Medical Center, Japan PE21-9 Examination of the long-term effect of oral immunotherapy in children with cow’s milk allergy Ryohei Suzuki, Yuriko Sekiguchi, Nagatoshi Sagara, Akiko Aota, Kenichi Akashi, Toshio Katsunuma Department of Pediatrics, Daisan Hospital, The Jikei University School of Medicine, Japan PE21-10 Exercise-induced allergic reactions after achievement of desensitization to cow’s milk and wheat Shohei Kubota, Katsumasa Kitamura, Teruaki Matsui, Yasuhiro Takasato, Shiro Sugiura, Komei Ito Department of Allergy, Aichi Children’s Health and Medical Center, Japan 510

PE21-11 Factors related to treatment outcome and adverse events in peanut rush oral immunotherapy Tomonori Ishiguro, Katsumasa Kitamura, Yoshihiro Takasato, Teruaki Matsui, Shiro Sugiura, Komei Ito Department of Allergy, Aichi Children’s Health and Medical Center, Japan PE21-12 Exercise-induced allergic reactions on desensitization to cow’s milk after rush oral immunotherapy Genki Tsuji, Teruaki Matsui, Yoshihiro Takasato, Katsumasa Kitamura, Shiro Sugiura, Komei Ito Department of Allergy, Aichi Children’s Health and Medical Center, Japan PE21-13 ω-5 gliadin-sIgE/total IgE predicts long-term outcome of low-dose OIT for severe wheat allergy Ken-ichi Nagakura1）, Noriyuki Yanagida1）, Sakura Sato2）, Yoko Miura1）, Makoto Nishino1）, Kyohei Takahashi1）, Tomoyuki Asaumi1）, Kiyotake Ogura1）, Motohiro Ebisawa2） Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2） PE21-14 2-year follow up of patients with wheat anaphylaxis after wheat oral immunotherapy Delara Babaie1）, Mehrnaz Mesdaghi1）, Mira Sahragard1）, Ramin Ghasemi2）, Habib Soheili3）, Fariborz Zandieh3）, Hamideh Seifi1）, Motohiro Ebisawa4） Allergy and Clinical Immunology, Mofid Children Hospital, SBMU, Iran1）; Allergy and Clinical Immunology, Isfahan Medical University, Iran2）; Allergy Clinic, Iran3）; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan4） PE21-15 Permanent tolerance induced by oral immunotherapy; is it a complete symptom-free condition? 6 month follow up after PT achievement Morteza Fallahpour, Saba Arshi, Mohammad Nabavi, Mohammad Hasan Bemanian, Sima Shokri Allergy & Clinical Immunology Department, Rasoul e Akram Hospital, Iran PE21-16 Does oral immunotherapy for food allergy impact allergic chidren BMI? Skander Larakeb1）, Carine Billard1）, Patricia Tome2） Department of Pediatrics, Meaux General Hospital, France1）; Allergology Unit, Aulnay Sous Bois Hospital, France2） PE21-17 Evaluation of the effectiveness of subcutaneous immunotherapy with birch pollen extract for pollen-food allergy syndrome associated with soybean allergy Masaaki Hamada1）, Masakazu Kagawa2）, Ichiro Tanaka1） Department of Pediatrics, Yao Municipal Hospital, Japan1）; Department of Clinical Research Center, Yao Municipal Hospital, Japan2） PE21-18 Real-world outcome of oral immunotherapy for food allergy Miyuki Hoshi, Shingo Yamada, Mayumi Matsunaga, Kazutaka Nogami, Kana Hamada, Keigo Kainuma, Mizuho Nagao, Takao Fujisawa Allergy Center, National Hospital Organization Mie National Hospital, Japan

Poster Session 22

Immunotherapy 1 PE22-1 Sublingual immunotherapy treatment for nine-year-old boy suffering from allergic rhinitis causing sleep disorders and school absenteeism Tamaki Ito1）, Ikuo Okafuji1）, Kiyoshi Kikuchi2）, Satoru Tsuruta1） Department of Pediatrics, Kobe City Medical Center General Hospital, Japan1）; Children’s Rehabilitation, Sleep and Neurodevelopmental Medical Center, Hyogo Prefectural Rehabilitation Center Hospital, Japan2） PE22-2 Induction of an eosinophilic gastroenteritis occurred during sublingual immunotherapy with Japanese cedar pollen extract: a case report Makoto Yasuda1）, Shota Okamoto1）, Takatoshi Nakajima2）, Shigeru Hirano1） Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Japan1）; Department of Gastroenterology, Takatsuki General Hospital, Japan2） PE22-3 Mastocytosis and tryptase in hymenoptera venom allergy: real world data from the United States 1） 1,2） 1,7） 3） 4） 5） 1,6） 1） otrSession Poster Dilawar Khokhar , Charles F Schuler , Sofija Volertas , Yunshen Jiao , Onur Baser , Huseyin Yuce , Jenny Montejo , Cem Akin Division of Allergy and Clinical Immunology, University of Michigan, USA1）; Mary H Weiser Food Allergy Center, University of Michigan, USA2）; Columbia Data Analytics, USA3）; MEF University, Turkey4）; Department of Mathematics, New York City College of Technology, USA5）; Mayo Clinic, USA6）; Division of Rheumatology, Allergy and Immunology, University of North Carolina, USA7） PE22-4 Efficacy and safety of allergen immunotherapy for allergic rhinitis with Kazuki Fujioka, Akiko Kasahara, Makoto Wada, Masataka Kohno, Yutaka Kawahito Department of Inflammation and Immunology, Kyoto Prefectural University of Medicine, Japan PE22-5 Sublingual immunotherapy improved nasal symptoms and allergen-specific nasal and skin reactivity in house dust mite-induced perennial allergic rhinitis patients Sawako Masuda, Satoko Usui Department of Otorhinolaryngology, National Hospital Organization Mie National Hospital, Japan PE22-6 Efficacy of sublingual immunotherapy for house dust mite allergic rhinitis in children Kayoko Kawashima1）, Masashi Yamamoto1）, Mika Okuno1）, Yuri Takaoka2）, Yukinori Yoshida2）, Makoto Kameda2） Department of Otorhinolaryngology, Osaka Habikino Medical Center, Osaka Prefectural Hospital Organization, Japan1）; Department of Pediatrics, Osaka Habikino Medical Center, Osaka Prefectural Hospital Organization, Japan2） PE22-7 A novel immuntherapy to airway allergy Mingi Chang, Yu Shen Hsu, Annie Pai Advagene Biopharma Co., Ltd., Taiwan PE22-8 Safety and efficacy of house dust mite subcutaneous immunotherapy (interim analysis of post-marketing surveillance from 2016 to 2019) Hiroki Matsuhara, Takeru Sugawara, Yuriko Maekawa, Remi Hashimoto, Keiichi Tanigchi Torii Pharmaceutical Co., Ltd., Japan PE22-9 Safety and efficacy of Japanese cedar pollen sublingual immunotherapy tablet under actual use condition (interim analysis of post- marketing surveillance from 2018 to 2019) Satoko Kobayashi, Yuriko Maekawa, Hiroko Honda, Eiji Horikawa, Chiyoko Kunishima, Noriaki Nishino Torii Pharmaceutical Co., Ltd., Japan 511

PE22-10 The efficacy of SQ HDM sublingual immunotherapy tablets in patients with HDM-induced allergic rhinitis in Japan (interim analysis of post-marketing surveillance from 2016 to 2019) Yuriko Maekawa, Remi Hashimoto, Keiichi Taniguchi, Hiroki Matsuhara, Chiyoko Kunishima, Noriaki Nishino Torii Pharmaceutical Co., Ltd., Japan PE22-11 Actual conditions of dual SLIT with Japanese cedar pollen sublingual immunotherapy products and SQ house dust mite sublingual immunotherapy tablet in Japan Yuriko Maekawa, Hiroki Matsuhara, Satoko Kobayashi, Eiji Horikawa, Keiichi Taniguchi, Noriaki Nishino Torii Pharmaceutical Co., Ltd., Japan PE22-12 Efficacy and safety of dual sublingual immunotherapy for Japanese cedar pollinosis and house dust mite allergic rhinitis Tatsuya Fujii1,2）, Yoshiaki Kitamura2）, Seiichiro Kamimura2）, Noriaki Takeda2） Department of Otolaryngology, JA Kochi Hospital, Japan1）; Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan2） PE22-13 Dose reduction in inhaled corticosteroid of sublingual immunotherapy during 3 years for allergic asthma with cedar pollinosis Kyohei Morita1）, Chie Yoshimura1）, Shinichi Sumimoto2）, Hiroki Ikeda3）, Toshitaka Morishima5）, Erika Toyokura1）, Kenta Nishi4）, Ryoichi Ishikawa1）, Masato Taki1）, Hwang Moonhee1）, Yasuo Nishizaka1） Department of Respiratory Medicine, Japanese Red Cross Osaka Hospital, Japan1）; Department of Pediatrics, Japanese Red Cross Osaka Hospital, Japan2）; Ikeda-jibika (E.N.T. clinic), Japan3）; Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan4）; Cancer Control Center, Osaka International Cancer Institute, Japan5） PE22-14 Safety of dual sublingual immunotherapy with house dust mite and Japanese cedar pollen tablets Naofumi Suzuki1）, Hisashi Nishimori1）, Jun Horie1）, Atsushi Kohso1）, Tomoya Harada1）, Hirotoshi Makino1）, Katsuhiko Ito1）, Keiko Yamaguchi1）, Yusuke Omori1）, Hodaka Ohta1）, Kenji Sugiyama1）, Eri Suzumura2）, Takao Fujisawa3） Department of Pediatrics, Mie Prefectural General Medical Center, Japan1）; Department of Otolaryngology, Mie Prefectural General Medical Center, Japan2）; Allergy Center, National Hospital Organization Mie National Hospital, Japan3） PE22-15 Medication compliance of sublingual immunotherapy in patients with house dust mite induced allergic rhinitis in Japan: a retrospective database study Yoshie Hongo1）, Martin Rees2）, Yuki Kado3）, Manami Yoshida1）, Shinzo Hiroi1）, Efstrathios Karagiannis2） Medical Affairs Department, Shionogi & Co., Ltd., Japan1）; Stallergenes Greer, France2）; IQVIA Solutions Japan K.K, Japan3） PE22-16 Efficacy and safety of sublingual immunotherapy in patients with allergic rhinitis induced by house dust mites Satoko Hamada1,2）, Yoshiki Kobayashi1,2）, Akihiro Shimamura1）, Daiki Sakamoto1）, Mikiya Asako1,2）, Hiroshi Iwai1） Department of Otorhinolaryngology, Kansai Medical University, Japan1）; Allergy Center, Kansai Medical University, Japan2） PE22-17 Long-term relief in allergic rhinitis children after sublingual immunotherapy Yang Park Department of Pediatrics, Wonkwang University Sanbon Hospital, Republic of Korea

Poster Session 23

Immunotherapy 2 PE23-1 Genome-wide transcriptome and copy number variation analysis for sublingual immunotherapy Osamu Kaminuma1,4）, Minoru Gotoh1,2）, Akihiro Nakaya1,3）, Mayumi Saeki1）, Tomoe Nishimura1）, Noriko Kitamura1）, Nobumasa Watanabe1）, Kimihiro Okubo1,2）, Takachika Hiroi1） Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Japan1）; Department of Otorhinolaryngology, Nippon Medical School, Japan2）; Department of Genome Informatics, Osaka University, Japan3）; Department of Disease Model, Hiroshima University, Japan4） PE23-2 Changes of immunological response with subcutaneous immunotherapy for Japanese cedar Tomoyuki Asaumi1）, Sakura Sato2）, Noriyuki Yanagida1）, Hiroki Matubara3）, Satoko Kobayashi3）, Chiharu Fukano3）, Katsuyo Ohashi-Doi3）, Motohiro Ebisawa2） 1） Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Japan ; Department of Allergy, Clinical Research Center for Session Poster Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2）; Torii Pharmaceuticals Co., Ltd., Japan3） PE23-3 The safety of SQ HDM sublingual immunotherapy tablets in patients with HDM-induced allergic rhinitis in Japan (interim analysis of post-marketing surveillance from 2016 to 2019) Shiori Saito, Yuriko Maekawa, Remi Hashimoto, Keiichi Taniguchi, Chiyoko Kunishima, Noriaki Nishino Torii Pharmaceutical Co., Ltd., Japan PE23-4 Development of a novel Cry j 1 allergoid using chemical modification Takeru Sugawara, Keisuke Suzuki, Fujinami Koji, Katsuyo Ohashi-Doi Research Laboratory, Torii Pharmaceutical Co., Ltd, Japan PE23-5 Sublingual immunotherapy with Japanese cedar pollen extract induces apoptosis of memory CD4+ T cells Hiroyuki Arai1）, Hideaki Kouzaki1）, Atsushi Yuta1,2）, Takeshi Shimizu1） Department of Otorhinolaryngology, Shiga University of Medical Science, Japan1）; Yuta Clinic, Japan2） PE23-6 Involvement of type 1 regulatory T (Tr1) in clinical effectiveness of sublingual immunotherapy (SLIT) Masaya Matsuda1）, Tetsuya Terada2）, Kazuyuki Kitatani1）, Ryo Kawata2）, Takeshi Nabe1） Laboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Japan1）; Department of Otorhinolaryngology-Head & Neck Surgery, Osaka Medical College, Japan2） PE23-7 Immunological responses during long-term sublingual immunotherapy with Japanese cedar droplet Tomokazu Matsuoka1,2）, Satoko Kobayashi3）, Katsuyo Ohashi-Doi3）, Kimihiro Okubo4）, Keisuke Masuyama2,5） Department of Otorhinolaryngology, Head & Neck Surgery, University of Yamanashi, Japan1）; Allergy Center, University of Yamanashi Hospital, Japan2）; Torii Pharmaceutical Co., Ltd., Japan3）; Department of Otolaryngology, Head and Neck Surgery, Nippon Medical School, Japan4）; Department of Otolaryngology, Suwa Central Hospital, Japan5） PE23-8 Significance of house dust mite components in the selection of specific immunotherapy Gabija Bilit1）, Asta Mikinien2）, Loreta Bagdonait3）, Jolita Norknien4）, Violeta Kvedarien5,6） Faculty of Medicine, Vilnius University, Lithuania1）; UAB In novum, Lithuania2）; Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, Lithuania3）; Vilnius Gediminas Technical University, Lithuania4）; Clinic of Chest diseases, Immunology and Allergology, Institute of Clinical Medicine, Vilnius University, Lithuania5）; Vilnius University Hospital Santaros Klinikos, Lithuania6） PE23-9 Changes in specific immunoglobulin G4 levels during pediatric subcutaneous immunotherapy with Japanese cedar pollen Mayumi Fujita, Shuntaro Tsumagari, Tetsuya Takamasu, Chisato Inuo Department of Allergy, Kanagawa Children’s Medical Center, Japan 512

PE23-10 Induction of Th1 CD4 T cells with peptide vaccine Takumi Kumai1,2）, Ryosuke Sato2）, Toshihiro Nagato2）, Yasuaki Harabuchi2） Department of Innovative Head & Neck Cancer Research and Treatment (IHNCRT), Asahikawa Medical University, Japan1）; Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Japan2） PE23-11 Comparison of immunological effect of standardized and non-standardized extracts in subcutaneous immunotherapy for children with house dust mite-induced perennial rhinitis Shuntaro Tsumagari, Mayumi Fujita, Tetsuya Takamasu, Chisato Inuo Department of Allergy, Kanagawa Chileren’s Medical Center, Japan PE23-12 The establishment of EXiLE test for House dust mite allergy Katsuyo Ohashi-Doi1）, Yuya Tanaka2）, Ikuo Okafuji2）, Satoru Tsuruta2）, Saori Ohmae1） Research Laboratory, Torii Pharmaceutical Co., Ltd, Japan1）; Department of Pediatrics, the Kobe City Medical Center General Hospital, Japan2） PE23-13 Allergen stability and immunological reactivity following dissolution and co-Incubation of house dust mite and Japanese cedar pollen SLIT-Tablets Katsuyo Ohashi-Doi, Hiroki Matsuhara, Takashi Yamamoto, Keisuke Suzuki, Hiroshi Nakazawa Research Laboratory, Torii Pharmaceutical Co., Ltd, Japan PE23-14 A role of basophil activation and antigen specific antibody in sublingual immunotherapy for seasonal allergic rhinitis Yosuke Baba1）, Kazuki Miyabayashi1,2）, Shoji Ishida1,2）, Takahiro Ebara1,2）, Mayuki Kojima2）, Hiromichi Yamada2）, Toshiyuki Yoneyama2）, Tomoaki Yokokura1,2）, Susumu Yamazaki2）, Asuka Honjo2）, Eisuke Inage2）, Takahiro Kudo2）, Yoshikazu Ohtsuka2）, Toshiaki Shimizu2） Department of Pediatrics, Juntendo University Shizuoka Hospital, Japan1）; Department of Pediatrics, Juntendo University School of Medicine, Japan2）

Poster Session 24

Mechanisms of Allergy PE24-1 Dipeptidyl peptidase-4 inhibitors and diuretics might frequently cause drug hypersensitivity in adults Shinichiro M Koga1）, Yu Noguchi1）, Takayuki Kajii2）, Ryo Sunaga2）, Ken Iozumi2） Department of Medicine, Tokyo Metropolitan Police Hospital, Japan1）; Department of Dermatology, Tokyo Metropolitan Police Hospital, Japan2） PE24-2 Is it Takayasu’s arteritis; autoimmune or infective? evidence from angiographic patterns in Sri Lanka Dewa Pakshage Chula Kanishka Ananda Lal Stoke University Hospital, UK PE24-3 Allergen pattern causing allergic rhinitis based on skin prick test result in ENT Outpatient Clinic Sanglah General Hospital Denpasar in 2019 Ni Luh Sartika Sari Department of Otorhinolaryngology - Head&Neck Surgery, RSUP Sanglah, Indonesia PE24-4 Microcirculatory changes in children with asthma depending on the allergological history Pavel Berezhanskiy, Andrey Fadeev, Yulia Berezhanskaya Odintsovo Regional Hospital, Odincovo, Russian Federation PE24-5 The flagellin allergen fusion protein rFlaA: Betv1 induces MyD88-, mTOR-, and MAPK-dependent immune metabolic activation of macrophages Stephan Scheurer, Yen-Ju Lin, Garibald Papp, Anna Fiedler, Alexandra Goretzki, Sonja Wolfheimer, Stefan Vieths, Stefan Schülke Molecular Allergology, Paul-Ehrlich-Institut, Germany PE24-6 Detection of eosinophil ETosis in eosinophilic granulomatosis with polyangiitis (EGPA) by citrullinated histone H3 immunostaining Mineyo Fukuchi1）, Yosuke Kamide2）, Shigeharu Ueki1）, Yui Miyabe1）, Chikako Furutani1）, Yuki Moritoki1）, Akiko Saga1）, Tomoo Saga1）, Masami Taniguchi2） Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Japan1）; Clinical Research 2） otrSession Poster Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan PE24-7 RNA binding protein HuR regulates cytokine expression in asthmatic CD4+T cells by controlling mRNA stability and translation Ulus Atasoy, Fatemeh Fattahi, Jason Ellis, Kristin Bahleda Department of Internal Medicine University of Michigan, USA PE24-8 Sleep quality in patients with allergic rhinitis: the relationship between endogenous melatonin and nasal mucus cytokine levels Aya Honma1,2）, Viktoria Grammatopoulou3）, Sofia Khan4）, Mohammed Y Karim5）, Masanobu Suzuki1）, Yuji Nakamaru1）, Akihiro Homma1）, Vishnu S Sunkaraneni3）, Debra J Skene2） Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan1）; Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, UK2）; Department of ENT, Royal Surrey County Hospital, UK3）; Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery, University College London Hospital, UK4）; Department of Immunology and Allergy, Royal Surrey County Hospital, UK5） PE24-9 Role of TRPC6 Channel in eosinophil function Akiko Sano, Hiroyuki Sano, Takashi Iwanaga, Yuji Tohda Department of Respiratory Medicine and Allergology, Kindai University, School of Medicine, Japan PE24-10 Protein phosphatase enhances IgE class switch recombination, buttonoIgG4 Kano Tanabe1）, Seiji Inui2） Department of Medical Technology, Kumamoto Health Science University, Japan1）; Sugimura Hospital, Japan2） PE24-11 Induction of T2 responses in human skin dermal cells by epidermal keratinocyte homogenate Shokei Murakami1,2）, Kyoko Futamura1）, Kenji Matsumoto1）, Akio Matsuda1） Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Japan1）; Department of Pediatrics, Toyama University School of Medicine, Japan2） PE24-12 Effects of β2-adrenergic agonists on house-dust mite-induced adhesion, superoxide anion generation, and degranulation of human eosinophils Yutaka Ueda1,2,3）, Kazuyuki Nakagome1,3）, Takehito Kobayashi1,3）, Toru Noguchi1,3）, Tomoyuki Soma1,3）, Kenichi Tokuyama1,2）, Makoto Nagata1,3） Allergy Center, Saitama Medical University, Japan1）; Department of Pediatrics, Saitama Medical University, Japan2）; Department of Respiratory Medicine, Saitama Medical University, Japan3） 513

PE24-13 Functional food ingredients modulate mast cell signaling Norimasa Tamehiro, Reiko Adachi, Kazunari Kondo Department of Biochemistry, National Institute of Health Sciences, Japan PE24-14 Activated platelets can enhance airway inflammation and remodeling Hoang Kim Tu Trinh1）, Kieu-Minh Le1）, Yoo Seob Shin2） Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam1）; Department of Allergy and Clinical Immunology, Ajou University Hospital, Republic of Korea2） PE24-15 The involvement of chitinase 3-like-1 in poly (I:C) induced airway inflammation Jaewoo Lee, Jung Yeon Hong, Mi Na Kim, Eun Gyul Kim, Kyung Won Kim, Myung Hyun Sohn Department of Pediatrics, Severance Hospital, Institute of Allergy, Yonsei University College of Medicine, Republic of Korea PE24-16 Sex-difference in associations between skin responses to purified protein derivative and family size during infancy in Japan Miwa S Shinohara1,2）, Kenji Matsumoto3） Departments of Pediatrics, Juntendo University, Faculty of Medicine, Japan1）; Departments of Pediatrics, Kochi University, Japan2）; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Japan3） PE24-17 Ephedra herb, Mao, inhibits allergen-induced mast cell degranulation by inducing IgE-FcεRI internalization Yuka Nagata1）, Hirokazu Ando2）, Yohei Sasaki2）, Ryo Suzuki1） Laboratory of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan1）; Laboratory of Molecular Pharmacognosy, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan2） PE24-18 Comparative evaluation of crude vis-a-vis purified allergen of Dermatophagoides farinae based on Indirect ELISA Anita Leishangthem1）, Venkatesh D P1）, Nagendra Prasad K V2）, Paranjothy K2）, Lakshmi K2） Department of Pharmaceutics, Acharya and BM Reddy College of Pharmacy, India1）; Bengaluru Allergy Centr, India2）

Poster Session 25

Microbiome and omics PE25-1 Proteomic profiling of non-invasively collected skin surface lipid samples to characterize infant skin Satoko Fukagawa, Kyoko Shima, Maeko Iwamura, Takayoshi Inoue, Junko Ishikawa, Noriyasu Ota, Takatoshi Murase Biological Science Research, Kao Corporation, Japan PE25-2 Bacterial flora in maternal feces, breast milk, breast skin, and 1-month breast milk and meconium Yumiko Komine1）, Yuki Fujimaki1）, Yasuho Shoda1）, Takehiko Soutome1）, Gaku Harata2）, Kenji Miyazawa2）, Fang He2）, Misa Watanabe1） Department of Pediatrics, Toho University School of Medicine, Japan1）; Takanashi Milk Products Co., Ltd, Japan2） PE25-3 Role of salivary microbiome in IL-10 production and efficacy of sublingual immunotherapy in allergic rhinitis Aiko Oka1）, Masanori Kidoguchi2,3）, Shin Kariya4）, Tazuko Fujiwara4）, Atsushi Yuta5）, Hiromi Miyashita5）, Takaya Higaki4）, Yukiko Ogawa5）, Kengo Kanai6）, Sei-ichiro Makihara7）, Takenori Haruna8）, Jun Kunisawa9）, Emiko Noguchi3）, Shigeharu Fujieda2）, Kazunori Nishizaki4）, Mitsuhiro Okano1,4） Department of Otorhinolaryngology, International University of Health and Welfare Graduate School of Medicine, Japan1）; Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Japan2）; Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Japan3）; Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan4）; Yuta Clinic, Japan5）; Department Otorhinolaryngology-Head & Neck Surgery, Kagawa Prefectural Central Hospital, Japan6）; Department Otorhinolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital, Japan7）; Department Otorhinolaryngology, Himeji St Mary’s Hospital, Japan8）; Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, and Laboratory of Gut Environmental System, National Institute of Biomedical Innovation, Health and Nutrition (NIBIOHN), Japan9） PE25-4 Identification of causative fungi in allergic bronchopulmonary mycosis by mycobiome analysis Yoshiki Shiraishi1）, Takashi Ishiguro2）, Junko Suzuki3）, Miyuki Wagatsuma4）, Kirill Kryukov5）, Kana Ohshinden1）, Jun Tanaka1）, 1） 1） 6） 4） 5） 1）

Katsuyoshi Tomomatsu , Tsuyoshi Oguma , Katsuhiko Kamei , Akira Hebisawa , Tadashi Imanishi , Koichiro Asano Session Poster Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan1）; Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan2）; Department of Pulmonary Medicine, National Hospital Organization, Tokyo National Hospital, Japan3）; Clinical Research Center, National Hospital Organization, Tokyo National Hospital, Japan4）; Biomedical Informatics Laboratory, Department of Molecular Life Science, Tokai University School of Medicine, Japan5）; Division of Clinical Research, Medical Mycology Research Center, Chiba University, Japan6） PE25-5 Gut microbiome analysis for Japanese patients with multiple chemical sensitivity/idiopathic environmental intolerance Kentaro Watai1）, Kiyoshi Sekiya1）, Masahira Hattori2）, Yuichiro Kawasaki1）, Norihiro Fujita1）, Maki Iwata1）, Kisako Nagayama1）, Koichi Yano1）, Yuto Nakamura1）, Yuto Hamada1）, Kai Ryu1）, Hiroaki Hayashi1）, Yosuke Kamide1）, Yuma Fukutomi1）, Masami Taniguchi1,3） Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan1）; Graduate School of Advanced Science and Engineering, Waseda University, Japan2）; Shonan Kamakura General Hospital, Center for Clinical and Translational Science, Japan3） PE25-6 Does gut microbiota affect sensitization to inhaled allergens? Atsushi Matsubara1）, Ayami Nomura1）, Junko Takahata1）, Shigeyuki Nakaji2） Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine, Japan1）; Department of Social Medicine, Hirosaki University School of Medicine, Japan2） PE25-7 Identification of novel biomarkers for asthma reflecting lung eosinophilia by the non-targeted proteomics of serum exosomes Hanako Yoshimura, Yoshito Takeda, Yuko Abe, Taro Koba, Yasuhiko Suga, Kiyoharu Fukushima, Shiroyama Takayuki, Shohei Koyama, Haruhiko Hirata, Kota Iwahori, Izumi Nagatomo, Atsushi Kumanogoh Graduate School of Medicine, Osaka University, Japan PE25-8 Surface bacterial flora in normal and dry mucosa Ryosuke Miwa1）, Masato Miwa2,3） Minato Swan Dental Clinic, Japan1）; Harimazaka Clinic, Japan2）; Atopy Research Center, Juntendo University, Japan3） 514

Poster Session 26

Other skin diseases 1 PE26-1 Effectiveness and safety of Omalizumab for chronic urticaria in Japanese children Akihiko Terada Terada Kid’s Allergy Clinic, Japan PE26-2 Allergic contact dermatitis to hair dye in 14-year-old male Karolina Dumycz, Joanna Zieli㶠ska, Beata Pyr㶊ak, Dominika Ambro㶊ej, Wojciech Feleszko Department of Pediatric Respiratory Diseases and Allergy, Medical University of Warsaw, Poland PE26-3 Temperament and character properties in patients with chronic urticaria Maryam Khoshkhui1）, Farhad Farid-Hosseini2） Allergy Research Center, Mashhad University of Medical Sciences, Iran1）; Pediatric Department, Mashhad University of Medical Sciences, Iran2） PE26-5 Role of anti ige (omalizumab) in chronic idiopathic urticaria in SaudiArabia Abdul Rehman Syed Internal Medicine/Allergy & Immunology, Almana General Hospital, Saudi Arabia PE26-6 Association between chronic spontaneous urticaria and sleep-disordered breathing Kisako Nagayama1）, Kiyoshi Sekiya1）, Kentaro Watai1）, Norihiro Fujita1）, Maki Iwata1）, Koichi Yano1）, Yuki Hashimoto2）, Yuto Nakamura1）, Yuto Hamada1）, Atsushi Miyake2）, Kai Ryu1）, Hiroaki Hayashi1）, Hanako Ohmatsu2）, Yosuke Kamide1）, Yuma Fukutomi1）, Masami Taniguchi3） Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan1）; Department of Dermatology, National Hospital Organization Sagamihara National Hospital, Japan2）; Shonan Kamakura General Hospital Center for Immunology and Allergology, Japan3） PE26-7 Chinese doctors’ understanding of hereditary angioedema and the unmet needs in diagnosis and treatment: a qualitative study N Zhao, Zhong Yuyan Medical Affairs, Takeda (China) International Trade Co., Ltd., China PE26-8 Lipid mediator profiles of chronic spontaneous urticaria and atopic dermatitis Maho Tagui1,2,4）, Shota Toyoshima2,3,4）, Yoshimi Miki5）, Takahiro Endo1,2,4）, Mana Ito1,2,4）, Yusuke Niwa1,2,4）, Yoshitaka Taketomi5,6）, Koremasa Hayama1,2,4）, Tomomi Sakamoto2,3,4）, Makoto Murakami5,6）, Tadashi Terui1,2,4）, Yoshimichi Okayama2,3,4） Department of Dermatology, Nihon University School of Medicine, Japan1）; Allergy and Immunology Research Project Team, Research Institute of Medical Science, Nihon University School of Medicine, Japan2）; Center for Institutional Reseach and Medical Education, Nihon University School of Medicine, Japan3）; Center for Allergy, Nihon University Shool of Medicine, Japan4）; Laboratory of Microenvironmental Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, the University of Tokyo, Japan5）; Department of Cellular Signaling, Faculty of Medicine, the University of Tokyo, Japan6） PE26-9 Chronic spontaneous urticaria and thyroid disease in the elderly Teresa Garriga-Baraut1,2）, Carlos Hernández2）, Andreu Garrigós2） Department of Pneumology, Allergy and Cystic Fibrosis, Pediatric Allergy Unit, Vall d’Hebron University Hospital, Spain1）; Centre Sociosanitari Putget Dolors Aleu, Generalitat de Catalunya, Spain2） PE26-11 Efficacy and safety of Ligelizumab for CSU in Japanese patients: subgroup analysis of phase 2b study Michihiro Hide1）, Atsushi Fukunaga2）, Mami Murakami3）, Eva Hua4）, Thomas Severin5）, Reinhold Janocha5）, Atsuyuki Igarashi6） Department of Dermatology, Institute of Biomedical and Health Sciences, Hiroshima University, Japan1）; Department of Dermatology, Kobe University, Japan2）; Novartis Pharma K.K., Japan3）; Shanghai Novartis Trading Ltd., China4）; Novartis Pharma AG, Switzerland5）; NTT Medical Center, Japan6） PE26-12 Immune status of pregnant women with chronic urticaria Oksana Gizinger1）, Victor Radzinsky2）, Elena Levkova1）, Anna Khisamova1） Immunology and Allergology, Peoples’ Friendship University of Russia, Russian Federation1）; Obstetrics and Gynecology, Peoples’ Friendship University of Russia, Russian Federation2） PE26-13 Immune status of pregnant women with acute urticaria 1） 3） 2） 1） otrSession Poster Oksana Gizinger , Victor Radzinsky , Natalya Mamylina , Elena Levkova Immunology and Allergology, Peoples’ Friendship University of Russia, Russian Federation1）; South Ural State Humanitarian Pedagogical University, Russian Federation2）; Obstetrics and Gynecology, Peoples’ Friendship University of Russia, Russian Federation3）

Poster Session 27

Other skin diseases 2 PE27-1 Periorbital angioedema with acquired idiopathic generalized anhidrosis (AIGA) associated with sweat allergy: a case report Mari Kishibe1）, Yuki Kobayashi1）, Shin Iinuma1）, Michihiro Hide2）, Akemi Ishida-Yamamoto1） Department of Dermatology, Asahikawa Medical University, Japan1）; Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University, Japan2） PE27-2 Gleich syndrome: a case report Natalhie Acuña-Ortega, Maria C Zarate-Hernández, Sandra N González-Díaz, Cindy E De Lira-Quezada, Ligia L Carrasco-Díaz, Rodrigo A De la Cruz-Cruz Regional Center of Allergy and Clinical Immunology, University Hospital“Dr José Eleuterio González”, Mexico PE27-3 Expression of IL-27 and IFN-gamma in cutaneous mastocytosis Tomonobu Ito, Tatsuo Maeda, Chizu Egusa, Takafumi Numata, Kazutoshi Harada, Ryoji Tsuboi Department of Dermatology, Tokyo Medical University Hospital, Japan PE27-4 The modern mass allergy is a syndrome of Demodectic Acariasis Rakhima Zhaxylykova Center of Traditional and Nontraditional Medicine, Kazakhstan PE27-5 Cutaneous manifestations in patients with systemic metal allergy Kazuo Takahashi1）, Zenro Ikezawa2）, Junichi Iwata3）, Chie Miyabe1）, Takaharu Ikeda1）, Tamihiro Kawakami1） Division of Dermatology, Tohoku Medical and Pharmaceutical University, Japan1）; Ai Dermatology & Allergology Clinic, Japan2）; Department of Dermatology, Atami Hospital, International University of Health and Welfare, Japan3） 515

PE27-6 Daily emollients and protective gloves for treatment of hand eczema: an open-labeled pilot study in medical professionals Sayaka Kuwatsuka1）, Yutaka Kuwatsuka1）, Saori Tomimura1）, Motoi Takenaka1）, Yoko Terasaka2）, Koichi Izumikawa2）, Yoshitomo Morinaga3,4）, Katsunori Yanagihara3）, Hiroyuki Murota1） Department of Dermatology, Nagasaki University Hospital, Japan1）; Infection Control and Education Center, Nagasaki University Hospital, Japan2）; Department of Laboratory Medicine, Nagasaki University Hospital, Japan3）; Department of Microbiology, Faculty of Medicine, University of Toyama, Japan4） PE27-7 Effect of Topical Immunotherapy with Squaric Acid Dibutylester for Alopecia Areata Satoshi Fukushima, Keisuke Sakai, Satoru Mizuhashi, Masatoshi Jinnin, Takamitsu Makino, Yuji Inoue, Hironobu Ihn Department of Dermatology, Kumamoto University, Japan PE27-8 Activated extrinsic coagulation factors induce degranulation of human skin mast cells and basophils through complement Yuhki Yanase1,2）, Yoshimi Matsuo1）, Tomoko Kawaguchi1）, Kaori Ishii1）, Kazue Uchida1）, Shunsuke Takahagi1）, Michihiro Hide1） Department of Dermatology, Hiroshima University, Japan1）; Department of Pharmacotherapy, Hiroshima University, Japan2） PE27-9 Long-term efficacy and safety of lanadelumab in patients with hereditary angioedema: interim results from the HELP open-label extension study Marc A Riedl1）, Paula J Busse2）, Raffi Tachdjian3）, Daniel Soteres4）, James Hao5）, Peng Lu5）, Aleena Banerji6） Division of Rheumatology, Allergy & Immunology, University of California San Diego, USA1）; Division of Allergy and Clinical Immunology, Icahn School of Medicine at Mount Sinai, USA2）; AIRE Medical of Los Angeles, University of California Los Angeles, USA3）; Asthma and Allergy Associates PC, USA4）; Shire, a Takeda company, USA5）; Massachusetts General Hospital, Harvard Medical School, USA6） PE27-10 Automatic detection of skin diseases using the extraction of texture features on the image and the naive bayes model algorithm Rifaldy Fajar, Nana Indri Kurniastuti, Prihantini Jupri Department of Computational Biology, Yogyakarta State University, Indonesia PE27-11 Metal patch testing in patients with oral symptoms Misato Maeno1）, Risa Tamagawa-Mineoka1）, Yukiyasu Arakawa1）, Koji Masuda1）, Tetsuya Adachi2）, Norito Katoh1） Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan1）; Department of Dental Medicine, Kyoto Prefectural University of Medicine, Japan2） PE27-12 RUDY JAPAN: Hereditary angioedema (HAE) online registry using information and communication technology (ICT) Ryo Saito1）, Kazumasa Iwamoto1）, Akio Tanaka1）, Kazuto Kato2）, Michihiro Hide1） Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan1）; Department of Biomedical Ethics and Public Policy, Graduate School of Medicine, Osaka University, Japan2） PE27-13 Self-administration of icatibant for the treatment of angioedema attacks: findings from the Icatibant Outcome Survey (IOS) Marcus Maurer1）, Hilary Longhurst2,3）, Werner Aberer4）, Laurence Bouillet5）, Anete Grumach6）, Jaco Botha7）, Irmgard Andresen7）, Giorgio Giannattasio7）, Teresa Caballero8） Charité Universitätsmedizin Berlin, Germany1）; Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service (NHS) Foundation Trust, UK2）; University College London Hospitals, UK3）; Medical University of Graz, Austria4）; National Reference Centre for Angioedema, Grenoble University, France5）; University Center Health ABC, Brazil6）; Shire (Takeda Pharmaceutical Company Limited.), Switzerland7）; Hospital Universitario La Paz, Biomedical Research Network on Rare Diseases (CIBERER, U754), Spain8） PE27-14 Prodromes and attack triggers in Canadian patients with hereditary angioedema Jane Hsieh1）, Jacquie Badiou2）, Rozita Borici-Mazi3）, Teresa Caballero4）, Amin Kanani5）, Gina Lacuesta6）, Christine McCusker7）, Susan Waserman8）, Stephen Betschel9） Department of Medicine, University of Toronto, Canada1）; Hereditary Angioedema (HAE), Canada2）; Department of Medicine, Queen’s University, Canada3）; Hospital Universitario La Paz, Spain4）; Department of Medicine, University of British Columbia, Canada5）; Department of Medicine, Dalhousie University, Canada6）; Department of Immunology, McGill University Health Centre, Canada7）; Department of Medicine, McMaster University, Canada8）; Department of Medicine, University of Toronto, Canada9） PE27-15 Assessment of quality of life and proximity to acute therapy in patients with hereditary angioedema Jane Hsieh1）, Jacquie Badiou2）, Rozita Borici-Mazi3）, Teresa Caballero4）, Amin Kanani5）, Gina Lacuesta6）, Christine McCusker7）, Susan Waserman8）, Stephen Betschel9） otrSession Poster Department of Medicine, University of Toronto, Canada1）; Hereditary Angioedema (HAE), Canada2）; Department of Medicine, Queen’s University, Canada3）; Hospital Universitario La Paz, Spain4）; Department of Medicine, University of British Columbia, Canada5）; Department of Medicine, Dalhousie University, Canada6）; Department of Immunology, McGill University Health Centre, Canada7）; Department of Medicine, McMaster University, Canada8）; Department of Medicine, University of Toronto, Canada9）

Poster Session 28

Pediatric Asthma 1 PE28-1 Asthma in Neonates; a systemic review of environmental causes of allergy present in Nigerian medical facilities Idowu G Oluwaseyi Department of Health Promotion and Enviromental Health Education, University of Ilorin, Nigeria PE28-2 Patterns of wheeze severity from early childhood to late adolescence: longitudinal transition analysis in a birth cohort study Matea Deliu1,2）, Sara Fontanella3）, Clare Murray4）, Angela Simpson4）, Adnan Custovic3） Department of Primary Care, University College London, UK1）; Division of Informatics, Imaging, and Data Science, University of Manchester, UK2）; Department of Paediatrics, Imperial College London, UK3）; Institute of Inflammation, University of Manchester, UK4） PE28-3 Automated decision support system as a screening tool in diagnosis of chronic non-specific bronchopulmonary disease in pediatric population- primary health care experience and literature review Ilgar Mustafaev1）, Veronica M Samedi1,2）, Lala Allahverdieva1） Azerbaijan Medical University, Azerbaijan1）; University of Saskatchewan, Canada2） PE28-4 Increase serum eosinophil cationic protein in preschool atopic asthma Pailin Yooma, Wiparat Manuyakorn, Wasu Kamchaisatian, Suwat Benjaponpitak, Watcharoot Kanchongkittiphon Department of Pediatrics Allergy and Immunology Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand PE28-5 Correlation between serum specific IgE and total IgE ratio (sIgE/tIgE ratio) with clinical response in pediatric asthma patients receiving allergen-specific immunotherapy Stephanie Kusbianto, Wisnu Barlianto, Desy Wulandari Department of Pediatric Allergy Immunology Saiful Anwar Hospital, Faculty of Medicine Brawijaya University, Indonesia 516

PE28-6 Prognostic factor analysis for clinical improvement in pediatric asthma patients with house dust mite (hdm) subcutaneous immunotherapy Mufida Hariani, Wisnu Barlianto, Desy Wulandari Department of Pediatric Allergy Immunology, Faculty of Medicine, Brawijaya University, Saiful Anwar Hospital, Indonesia PE28-7 A retrospective study of 1600 cases of bronchial asthma hospitalization over 10 years Takanori Yanai, Hiromi Tadaki, Hiromi Shioya, Yoichi Kaburagi Department of Pediatrics, National Health Organization Yokohama Medical Center, Japan PE28-8 Bronchial responsiveness 5-class model and its association with baseline spirometry and fractional exhaled nitric oxide in children Ji Soo Park, Min Jung Kim, Jihye Kim, Yun Jung Choi, Dong In Suh Department of Pediatrics, Seoul National University Hospital, Republic of Korea PE28-9 Risk of house dust mite sublingual immunotherapy in pediatric patients with allergic asthma Yuto Kondo1）, Hisashi Tanida1）, Yasutaka Hirabayashi2）, Jun Wakatsuki3）, Takayasu Nomura1） Department of Pediatrics, Nagoya City University Graduate School of Medical Sciences, Japan1）; Hibarigaoka Kids Allergy Clinic, Japan2）; Wakatsuki Kids Allergy Clinic, Japan3） PE28-10 Outcome of preschool asthma in school age: a biomarker-defined cohort study Kana Hamada, Mayumi Matsunaga, Shingo Yamada, Miyuki Hoshi, Kazutaka Nogami, Taiga Kobori, Keigo Kainuma, Mizuho Nagao, Takao Fujisawa Allergy Center, National Hospital Organization Mie National Hospital, Japan PE28-11 Recent practice patterns and variations in children hospitalized for asthma exacerbation in Japan Kenta Horimukai1）, Yusuke Okubo2,3,4）, Nobuaki Michihata5）, Kojiro Morita4）, Hiroki Matsui4）, Kiyohide Fushimi6）, Hideo Yasunaga4） Department of Pediatrics, Jikei University Katsushika Medical Center, Japan1）; Department of Epidemiology, University of California, Los Angeles, Fielding School of Public Health, United States of America2）; Department of Social Medicine, National Center for Child Health and Development, Japan3）; Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Japan4）; Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, Japan5）; Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medicine, Japan6） PE28-12 Vitamin D deficiency in asthmatic children Yang Park Department of Pediatrics, Wonkwang University Sanbon Hospital, Republic of Korea PE28-13 The structure of sensitization by allergens in children with allergic diseases in Azerbaijan Tahira Panahova Department of Children’s Diseases, Azerbaijan PE28-14 Sex differences in effects of lung function on body composition in peri-pubertal status Ju Hee Kim1）, Jun Ah Kim1）, Dong Keon Yon1）, Eun Kyo Ha2）, Hye Mi Jee1）, Seoung Won Lee3）, Man Yon Han1） Department of Pediatrics, CHA Bundang Medical Center, Republic of Korea1）; Department of Pediatrics, Kangnam Sacred Heart Hospital, Republic of Korea2）; Department of Data Science, Sejong University College of Software Convergence, Republic of Korea3）

Poster Session 29

Pediatric Asthma 2 PE29-1 Clinical characteristics of asthmatic adolescents with versus without persistent bronchial hyperresponsiveness Younghwan Kim, Yoon Young Jang, Hai Lee Chung Department of Pediatrics, School of Medicine, Daegu Catholic University Medical Center, Republic of Korea PE29-2 The modified pulmonary index score as an indicator of hospitalization for acute asthma exacerbation in children with fever Ryohei Suzuki, Nagatoshi Sagara, Akiko Aota, Kenichi Akashi, Toshio Katsunuma Department of Pediatrics, Daisan Hospital, The Jikei University School of Medicine, Japan

otrSession Poster PE29-3 Study of eight cases of pediatric bronchial asthma attacks requiring intensive care management in Fukushima Prefecture Ryo Maeda1）, Kazufumi Yaginuma1）, Yasushi Saito1）, Masahiro Watanabe1）, Kazuhide Suyama1）, Masatoki Sato1）, Koichi Hashimoto1）, Hiroko Sakuma2）, Mitsuaki Hosoya1） Department of Pediatrics, Fukushima Medical University, Japan1）; Department of Pediatrics, Hoshi General Hospital, Japan2） PE29-4 Development and validation of a new control questionnaire to aim for a high level of control for children and adolescents Mayumi Matsunaga1）, Makoto Kameda2）, Masanori Ikeda3）, Yasunori Ito4）, Toshishige Inoue5）, Ken-ichi Tokuyama6）, Kota Hirai7）, Tomoyo Matsubara8）, Yukinori Yoshida2）, Mizuho Nagao1）, Takao Fujisawa1） Allergy Center, National Hospital Organization Mie National Hospital, Japan1）; Department of Pediatrics, Osaka Habikino Medical Center, Japan2）; Department of Pediatrics, Okayama University Graduate School of Medicine, Japan3）; Department of Pediatrics, University of Toyama, Japan4）; Department of Pediatrics, Sumitomo Hospital, Japan5）; Department of Pediatrics, Saitama Medical University, Japan6）; Department of Pediatrics, Tokai University Hachioji Hospital, Japan7）; Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, Japan8） PE29-5 Classification of wheezing children in rural Bangladesh by intensity of Ascaris infection, total and specific Ig E levels, history of pneumonia and other risk factors Haruko Takeuchi1）, Alfazal Khan2）, Khalequz Zaman2）, Sayaka Takanashi3）, Tafsir Hasan2）, Mohammad Yunus2）, Masamine Jimba1）, Tsutomu Iwata4） Community and Global Health, The University of Tokyo, Japan1）; International Centre for Diarrhoeal Disease Research, Bangladesh2）; Developmental Medical Sciences, The University of Tokyo, Japan3）; The Graduate School of Humanities and Life Sciences, Tokyo Kasei University, Japan4） PE29-6 Features of respiratory function in pediatric asthma based on the degree of obesity Takehiko Soutome, Misa Watanabe, Hiroshi Miyashita, Yuki Fujimaki, Yasuho Shoda, Yumiko Komine, Akira Ohara Department of Pediatrics, Toho University Omori Medical Center, Japan PE29-7 Sex difference, severity of asthma and exercise-induced wheezing among children Satoshi Honjo1）, Yoko Murakami1）, Hiroshi Odajima1）, Yuichi Adachi2）, Koichi Yoshida3）, Yukihiro Ohya4）, Akira Iino5） Department of Paediatrics, National Hospital Organization Fukuoka National Hospital, Japan1）; Department of Paediatrics, Faculty of Medicine, Graduate School of Medicine and Pharmaceutical Science for Education, Toyama University, Japan2）; Division of Allergy, Tokyo Metropolitan Children’s Medical Centre, Japan3）; Division of Allergy, National Centre for Child Health and Development, Japan4）; Department of Paediatrics, Nasunogahara Clinic, Japan5） PE29-8 Comparison of forced oscillation technique and spirometry in asthmatic children Takuya Oda, Kota Ikari, Moeri Tsuji, Masaru Kawamura, Junichiro Tezuka Department of Allergy and Pulmonology, Fukuoka Children’s Hospital, Japan 517

PE29-9 Objective evaluation of airway hypersensitivity using breath sound analysis: a multicenter, prospective study in children up to 3 years old Manabu Miyamoto1）, Shigemi Yoshihara1）, Hiromi Tadaki2）, Hiromi Shioya2）, Hideyuki Tabata3）, Hiroyuki Mochizuki3） Department of Pediatrics, Dokkyo Medical University, Japan1）; Division of Pediatrics, National Hospital Organization Yokohama Medical Center, Japan2）; Department of Pediatrics, Tokai University School of Medicine, Japan3） PE29-10 A randomized, single-blind, placebo-controlled study on the efficacy of the Tulobuterol Patch (TP-LABA) in treating acute exacerbation of chronic bronchitis in children Chang-Keun Kim1）, Eun-Mi Kwon1）, Young-Ho Kim1）, Zak Callaway1,2）, Sang-Hee Jung1） Department of Pediatrics, Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Republic of Korea1）; School of Biological Sciences, University of Ulsan, Republic of Korea2） PE29-11 Longitudinal changes in lung function during childhood and adolescence with asthma Shingo Yamada, Mayumi Matsunaga, Kazutaka Nogami, Kana Hamada, Miyuki Hoshi, Keigo Kainuma, Mizuho Nagao, Takao Fujisawa Allergy Center, National Hospital Organization Mie National Hospital, Japan PE29-12 Clinical utility of Eosinophil-Derived Neurotoxin (EDN) in diagnosis of asthma inpreschool children with acute wheezing Taiga Kobori1,2）, Mizuho Nagao1）, Niclas Rydell3）, Takao Fujisawa1） Allergy Center, National Hospital Organization Mie National Hospital, Japan1）; Department of Pediatrics, Odawara Municipal Hospital, Japan2）; Thermo Fisher Scientific, Sweden3） PE29-13 Questionnaire survey on the opinions among caregivers about COVID-19 and their clinic visit and children’s cough in a clinic at Nagoya city Manabu Miyamoto1,2）, Kazunori Arai3,4）, Akihiko Terada5）, Naoto Watanabe3）, Sohei Makino3）, Shigemi Yoshihara1） Department of Pediatrics, Dokkyo Medical University, Japan1）; Department of Pediatrics, Nasu Red Cross Hospital, Japan2）; Tokyo Allergy and Respiratory Disease Research Institute, Japan3）; Promotion Committee for ILCA (I love clean air) Blue Ribbon Movement, Japan4）; Terada Kid’s Allergy and asthma Clinic, Japan5）

Poster Session 30

Pollinosis PE30-1 Relationship between the total tear IgE, serum specific IgE, and total serum IgE levels in patients with pollen allergic conjunctivitis Yasuo Yamana1）, Eiichi Uchio2） Yamana Eye Clinic, Japan1）; Department of Ophthalmology, Fukuoka University, Japan2） PE30-2 Revision of threshold levels for evoking pollinosis to oak, pine, Japanese hop, and ragweed in Seoul metropolitan area, Korea Young Jin Choi1）, Kyung Suk Lee1）, Jae Won Oh1）, Kyu Rang Kim2）, Yung-Seop Lee3） Department of Pediatrics, Hanyang University Guri Hospital, Republic of Korea1）; Applied Meteorology Research Division, National Institute of Meteorological Science, Republic of Korea2）; Department of Statistics, Dongguk University, Republic of Korea3） PE30-3 The correlation with pollination and increased sensitization rate of pollen allergens of children in Seoul metropolitan area Kyung Suk Lee1）, Young-Jin Choi1）, Kyunghoon Kim2）, Yung-Seop Lee3）, Kyu-rang Kim4）, Jae-Won Oh1） Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University College of Medicine, Republic of Korea1）; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Republic of Korea2）; Departement of Statistics, Dongguk University, Republic of Korea3）; Applied Meteorology Research Division, National Institute of Meteorological Sciences, Republic of Korea4） PE30-4 Japanese cedar pollen sublingual immunotherapy tablets suppressed the clinical symptoms of Japanese cypress pollinosis without additional safety concerns (Ad Hoc Analysis of 206-2-1 trial) Tomoya Kurokawa1,2）, Yuriko Maekawa3）, Hisataka Tanaka3）, Mitsuhiro Okano4）, Kimihiro Okubo5）, Yoshitaka Okamoto6） Clinical Research Center, Chiba University Hospital, Japan1）; Otorhinolaryngology, Head and Neck Surgery, Chiba University Hospital, Japan2）; Medical Affairs Department, Torii Pharmaceutical Co., Ltd., Japan3）; Otorhinolaryngology, International University of Health and Welfare, Japan4）; Department of Head & Neck and Sensory Organ Science, Nippon Medical School, Japan5）; President, Chiba Rosai Hospital, Japan6）

PE30-5 Relationship between ocular and nasal symptoms in Japanese cedar pollinosis Session Poster Yukiyoshi Hyo1,2）, Tarou Saika1）, Masakazu Hamamoto1）, Ayaka Yokoyama1）, Hirotaka Hara1） Department of Otolaryngoglogy, Kawasaki Medical School, Japan1）; Hyo ENT Clinic, Japan2） PE30-6 Knowledge, attitude and practices among patients and physicians on allergic rhinitis (KAPPA) study: Japan and Korea results Sheila Chua1）, Anup Pingle2）, Jeanne M Pimenta3）, Yoshitaka Okamoto4）, Julie Pacer5）, Jason Brinkley5） Global, Classic & Established Products, GlaxoSmithKline, Philippines1）; Global, Classic & Established Products, GlaxoSmithKline, India2）; Respiratory Epidemiology, Value Evidence and Outcome, GlaxoSmithKline, UK3）; Chiba University, Japan4）; Abt. Associates, USA5） PE30-7 The relationship between hay fever symptoms and antibody titers of IgE, allergen-specific IgE, total IgE, and cross-reactive carbohydrate determinant antigens in a company health examination Hidenori Yokoi1）, Yoshiyuki Takato2）, Kiyomi Shinagawa2）, Koichiro Saito1） Department of Otolaryngology, Kyorin University, Japan1）; SHIDAX Research Institute, Japan2） PE30-8 Pollen sensitization pattern in patients with allergic diseases in the last 16 years in Mexico Oscar I Moreno, Elsy M Navarrete, Blanca E Del Rio Department of Allergy and Immunology Federico Gómez Mexico Children’s Hospital, Mexico PE30-9 Time trend study of sensitization rates to three inhalant allergens in Japanese school children Takashi Kusunoki1,3）, Jiro Takeuchi2）, Takeshi Morimoto2）, Takahiro Yasumi3）, Junko Takita3） Department of Pediatrics, Shiga Medical Center for Children, Japan1）; Department of Clinical Epidemiology, Hyogo College of Medicine, Japan2）; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Japan3） PE30-10 The treatment results of selective resection of the posterior nasal nerve for intractable allergic rhinitis Yusuke Suzuki1）, Yasuhiro Abe1）, Kazuya Kurakami1）, Yui Kawai1）, Chihiro Watanabe1）, Yusuke Nouchi1）, Takashi Asano1）, Nobuo Ohta2）, Seiji Kakehata1） Department of Otolaryngology, Yamagata University, Japan1）; Division of Otolaryngology, Tohoku Medical and Pharmaceutical University, Japan2） PE30-11 Clinical characteristics of Japanese patients with physician-diagnosed allergic rhinitis in the JMDC claims database Hajime Yoshisue1）, Chie Ito2）, Mitsuhiro Okano3） Medical Division, Novartis Pharma K.K., Japan1）; JMDC Co. Ltd., Japan2）; Department of Otorhinolaryngology, International University of Healthand Welfare School of Medicine, Japan3） 518

PE30-12 The relation between -221 X/Y polymorphism of the MBL2 gene and MBL serum level in atopic patients Gantulga Batbayar1）, Munkhbayarlakh Sonomjamts2）, Enkhbayar Bazarsad3）, Buyankhuu Tuvshintur4）, Narantsetseg Logii5） Mongolian National University of Medical Science, Mongolia1）; Department of Molecular Biology, Core Laboratory, Mongolia2）; Research Laboratory, Effect Hospital, Mongolia3）; National Center for Transfusion Medicine, Mongolia4）; School of Biomedicine, Mongolian National University of Medical Science, Mongolia5） PE30-13 Efficacy of sublingual immunotherapy for Japanese cedar pollinosis allergic rhinitis in children Shohei Tanaka1）, Kayoko Kawashima1）, Masashi Yamamoto1）, Mika Okuno1）, Toshinobu Nakatake2）, Yuki Tsurinaga2）, Yohei Hukazawa2）, Tamana Nakano2）, Amane Shigekawa2）, Yuri Takaoka2）, Yukinori Yoshida2）, Makoto Kameda2） Department of Otorhinolaryngology, Osaka Habikino Medical Center, Osaka Prefectural Hospital Organization, Japan1）; Department of Pediatrics, Osaka Habikino Medical Center, Osaka Prefectural Hospital Organization, Japan2）

Poster Session 31

Rhinosinusitis PE31-1 Nasal therapies affect the levels of allergic shiners in children with allergic rhinitis Cheng-Tsung Yang1,2）, Bor-Luen Chiang2,3,4） Department of Pediatrics, Camillian Saint Mary’s Hospital Luodong, Taiwan1）; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taiwan2）; Department of Pediatrics, National Taiwan University Children’s Hospital, Taiwan3）; Department of Medical Research, National Taiwan University Hospital, Taiwan4） PE31-2 Saddle nose in patient with ethmoidal fungus balls Niken Lestari Poerbonegoro, Retno Sulistyo Wardani Department of Otorhinolaryngology-HNS, Universitas Indonesia-Dr Cipto Mangunkusumo Hospital, Indonesia PE31-3 Upper airway cough syndrome (UACS) in children with chronic cough Momoko Sakurai1）, Natsuko Masumoto1）, Rieko Higashishima1）, Yoshito Ishizaki1）, Junichiro Tezuka2） Department of Pediatrics, National Hospital Organization Fukuokahigashi Medical Center, Japan1）; Department of Allergy and Pulmonology, Fukuoka Children’s Hospital, Japan2） PE31-4 Objective evaluation of the deviation of nasal septum and selection of surgical techniques Shogo Kimura, Yuji Nakamaru, Masanobu Suzuki, Aya Honma, Akira Nakazono, Akihiro Homma Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan PE31-5 Benralizumab for eosinophilic sinusitis or otitis media complicated with bronchial asthma Taro Saika, Hyo Yukiyoshi, Ayaka Yokoyama, Masakazu Hamamoto, Hirotaka Hara Kawasaki Medical School, Japan PE31-6 Local zinc depletion promotes cytokine secretion and infiltration of inflammatory cells in nasal mucosa Masanobu Suzuki1）, Yuji Nakamaru1）, Mahnaz Ramezanpour2）, Takayoshi Suzuki1）, Aya Honma1）, Akira Nakazono1）, Shogo Kimura1）, Peter-John Wormald2）, Sarah Vreugde2）, Akihiro Homma1） Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan1）; Department of Surgery Otorhinolaryngology Head and Neck Surgery, the Queen Elizabeth Hospital, and the University of Adelaide, Australia2） PE31-7 Clinical characteristics and symptoms of eustachian tube dysfunction among chronic rhinosinusitis patients in Sanglah Hospital Denpasar, Bali-Indonesia Anak Agung Sagung Dewi Nurgitayanti1）, Sari Wulan Dwi Sutanegara2）, Ni Luh Sartika Sari3） Otolaryngology, Head, and Neck Surgery, Faculty of Medicine, Universitas Udayana-Sanglah General Hospital, Indonesia1）; Rhinology Division, Otolaryngology, Head, and Neck Surgery Department, Faculty of Medicine, Universitas Udayana-Sanglah General Hospital, Indonesia2）; Allergy and Immunology Division, Otolaryngology, Head, and Neck Surgery Department, Faculty of Medicine, Universitas Udayana-Sanglah General Hospital, Indonesia3） PE31-8 Successful management of eosinophilic chronic rhinosinusitis complicated by severe asthma using dupilumab, following negative

otrSession Poster initial results with benralizumab Isao Suzaki1）, Akihiko Tanaka2）, Kojiro Hirano1）, Sawa Kamimura1）, Yuki Maruyama1）, Yoichiro Narikawa1）, Eriko Sekino1）, Hitome Kobayashi1） Department of Otorhinolaryngology, School of Medicine, Showa University, Japan1）; Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University, School of Medicine, Japan2） PE31-9 Fipronil upregulates inflammatory cytokines and MUC5AC expression in human nasal epithelial cells Yong-Dae Kim1,2）, Yoon Seok Choi1）, Hyung Gyun Na1）, Chang Hoon Bae1）, Si-Youn Song1）, Soyoung Kwak2） Department of Otorhinolaryngology-Head Neck Surgery, College of Medicine, Yeungnam University, Republic of Korea1）; Regional Center for Respiratory Disease, Yeungnam University Medical Center, Republic of Korea2） PE31-10 Effect of PM10 exposure time on allergic rhinitis in Korea Dae Hyun Lim1,2）, Jeong Hee Kim1,2） Department of Pediatrics, Inha Universiy Hospital, Republic of Korea1）; Environmental Health Center for Allergic Diseases, Inha University Hospital,, Republic of Korea2） PE31-11 Immuno-histological analysis of sinusitis tissue from the cases who were not fully improved after anti-IL-5 therapy Kazuyuki Chibana1）, Taichi Shiobara1）, Yukiko Horigane1）, Yusuke Nakamura1）, Ryo Arai1）, Akihiro Takemasa1）, Yasuo Shimizu1）, Shinichi Haruna2）, Seiji Niho1） Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine, Japan1）; Department of Otorhinolaryngology, Dokkyo University School of Medicine, Japan2） PE31-12 Plasma galectin-10 levels and mucosal eosinophil infiltration in chronic rhinosinusitis Takechiyo Yamada1）, Yui Miyabe1）, Hidekazu Saito1）, Shigeharu Fujieda2）, Shigeharu Ueki3） Department of Otorhinolaryngology, Head and Neck Surgery, Akita University, Japan1）; Department of Otorhinolaryngology-Head and Neck Surgery, University of Fukui, Japan2）; Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University, Japan3） PE31-13 Investigation about sensitization rate of inhalable antigens in Hirosaki city for 10years Junko Takahata, Atsushi Matsubara Department of Otorhinolaryngology, Hirosaki University, Japan PE31-14 Investigation of the effect of benralizumab for chronic rhinosinusitis with nasal polyps Masashi Yamamoto1）, Kayoko Kawashima1）, Mika Okuno1）, Seijirou Minamoto2）, Osamu Matsuno2） Department of Otorhinolaryngology, Osaka Habikino Medical Center, Japan1）; Department of Allergy, Osaka Habikino Medical Center, Japan2） 519

PE31-15 Epidemiological study of allergic diseases, symptoms, and quality of life in school children Ayaka Yokoyama, Yukiyoshi Hyo, Tarou Saika, Masakazu Hamamoto, Hirotaka Hara Department of Otolaryngology, Kawasaki Medical School, Japan PE31-16 Prevalence of sleep disorders in children with allergic rinitis Maria Del Carmen Zarate Hernandez, Sandra N Gonzalez, Genhssy K Rocha, Argentina Rodriguez, Maria Del Rocio Salinas, Diana M Rangel Regional Center of Allergy and Clinical Immunology, Mexico PE31-17 Impact of eosinophilic status on efficacy of dupilumab in the JESREC subpopulations of phase 3 SINUS-52 study for severe chronic rhinosinusitis with nasal polyps Shigeharu Fujieda1）, Shoji Matsune2）, Sachio Takeno3）, Nobuo Ohta4）, Mikiya Asako5）, Claus Bachert6,7）, Martin Desrosiers8）, Tomoyuki Inoue9）, Yoshinori Takahashi9）, Hiroyuki Fujita9）, Benjamin Ortiz10）, Yongtao Li11）, Nikhil Amin10）, Leda P Mannent12） Department of Otorhinolaryngology University of Fukui, Japan1）; Nippon Medical School, Japan2）; Hiroshima University Hospital, Japan3）; Tohoku Medical and Pharmaceutical University, Japan4）; Kansai Medical University, Japan5）; Ghent University, Belgium6）; Karolinska Institutet, Sweden7）; CRCHUM, Canada8）; Sanofi K.K., Japan9）; Regeneron Pharmaceuticals, Inc., USA10）; Sanofi U.S., USA11）; Sanofi France, France12） PE31-18 Baseline characteristics of patients with CRSwNP with asthma and dupilumab efficacy by baseline biomarker level: results from the SINUS-24 and SINUS-52 phase 3 trials Mikiya Asako1）, Shigeharu Fujieda2）, Yoshiki Kobayashi1）, Jorge F Maspero3）, Joaquim Mullol4）, Claus Bachert5,6）, Martin Desrosiers7）, Mei Zhang8）, Xuezou Mao8）, Nikhil Amin9）, Leda P Mannent10） Department of Otorhinolaryngology, Kansai Medical University, Japan1）; University of Fukui, Japan2）; Fundación CIDEA, Argentina3）; Universitat de Barcelona, Spain4）; Ghent University, Belgium5）; Karolinska Institutet, Sweden6）; CRCHUM, Canada7）; Sanofi U.S., USA8）; Regeneron Pharmaceuticals, Inc, USA9）; Sanofi France, France10） PE31-19 A retrospective study on the safety of Japanese cedar pollen and house dust mite sublingual immunotherapy in children with multiple allergies Hiroshi Kitazawa, Yukari Ichikawa, Shuhei Oba, Eiichiro Kawai, Naomi Hino-Fukuyo, Tetsuji Morimoto Division of Pediatrics, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan PE31-20 Powder hydroxypropylmethylcellulose as add-on to nasal steroid improves the outcomes of nasal polyps conservative treatment Todor A Popov1）, Tania Z Kralimarkova2）, Diana Hristova2）, Tihomir B Mustakov2）, George Christoff2） Department of Occupational Disease, University Hospital St. Ivan Rilski, Bulgaria1）; Medical University Sofia, Bulgaria2）

Poster Session 32

Treatment for adult asthma 1 PE32-1 Evaluation of the qualitative assessment of asthma management by the Health Insurance Review and Assessment Service (HIRA) Hyeon-Jong Yang1）, Nam-Eun Kim2）, Sanghun Lee3）, Sungho Won1,4,5） Department of Pediatrics, Soonchunhyang University Seoul Hospital, Republic of Korea1）; Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Republic of Korea2）; Department of Medical Consilience, Graduate School, Dankook University, Republic of Korea3）; Interdisciplinary Program of Bioinformatics, Seoul National University, Republic of Korea4）; Institute of Health and Environment, Seoul National University, Republic of Korea5） PE32-2 Real-world study of prescription pattern of inhaled corticosteroids in adult asthma Yu Nakanishi1）, Hiroshi Iwamoto1）, Satoshi Nakao1）, Naoko Higaki1）, Kakuhiro Yamaguchi1）, Shinjiro Sakamoto1）, Yasushi Horimasu1）, Takeshi Masuda1）, Naoko Matsumoto2）, Taku Nakashima1）, Shintaro Miyamoto1）, Yojiro Onari3）, Kazunori Fujitaka1）, Yoshinori Haruta4）, Hironobu Hamada1）, Soichiro Hozawa5）, Noboru Hattori1） Department of Respiratory Internal Medicine, Hiroshima University Hospital, Japan1）; Department of Respiratory Internal Medicine, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Japan2）; Department of Respiratory Internal Medicine, Hiroshima Mazda Hospital, Japan3）; Haruta Respiratory Clinic, Japan4）; Hiroshima Allergy & Respiratory Clinic, Japan5）

PE32-3 The association of hyposmia on cognitive function and asthma control in asthmatics Session Poster Hyo-In Rhyou, Young-Hee Nam Department of Internal Medicine, College of Medicine, Dong-A University, Republic of Korea PE32-4 Prevalence, underlying diseases and patient characteristics of chronic cough patients in Japan: a web-based survey Kotoba Okuyama, Keisuke Tobe, Takekazu Kubo, Masashi Kikuchi, Yirong Chen, Jonathan Schelfhout, Shigeru Tokita, Machiko Abe Medical Affairs, MSD K.K., Japan PE32-5 Development of a new mouthpiece for pMDI Reiko Ito1）, Kazuto Nakagawa2）, Fujio Koeda3）, Yasuhiro Gon1） Department of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Japan1）; Department of Conceptual Design, Nihon University College of Industrial Technology, Japan2）; Department of Design, Nihon University College of Art, Japan3） PE32-6 Comparison of montelukast vs tiotropium as add-on therapy to inhaled corticosteroid plus a long-acting β2-agonist in asthma Makoto Hoshino1）, Kenta Akitsu2）, Junichi Ohtawa2） Division of Clinical Allergy, Department of Internal Medicine, Atami Hospital, International University of Health and Welfare, Japan1）; Department of Radiology, Atami Hospital, International University of Health and Welfare, Japan2） PE32-7 Triple therapy with budesonide/glycopyrrolate/formoterol is effective for asthma-COPD overlap Yoshihisa Ishiura1）, Masaki Fujimura2）, Noriyuki Ohkura3）, Johsuke Hara3）, Kazuo Kasahara3）, Yusuke Sawai1）, Takeshi Tamaki1）, Toshiki Shimizu1）, Shosaku Nomura1） First Department of Internal Medicine, Kansai Medical University, Japan1）; Respiratory Medicine, National Hospital Organization Nanao Hospital, Japan2）; Respiratory Medicine, Kanazawa University Hospital, Japan3） PE32-8 Effect of Japanese cedar pollen sublingual immunotherapy for asthma patients with Japanese cedar pollinosis Sumiko Abe1）, Jun Ito1）, Yuuki Sandhu1）, Takayasu Watanabe1）, Takayasu Nishimaki1）, Yukari Oyama1）, Shoko Ueda1）, Hitoshi Sasano1）, Yuki Tanabe1）, Tomohito Takeshige1）, Sonoko Harada2）, Ryo Atsuta1）, Norihiro Harada1）, Kazuhisa Takahashi1） Department of Respiratory, Juntendo Hospital, Japan1）; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Japan2） PE32-9 Prediction of future risks of asthma exacerbation using fractional exhaled nitric oxide and asthma control test questionnaire Manabu Uematsu, Junpei Saito, Suguru Sato, Asturo Fukuhara, Yasuhito Suzuki, Mami Rikimaru, Takaya Kawamata, Ryuichi Togawa, Yuki Sato, Takefumi Nikaido, Yoshinori Tanino, Yoko Shibata Depatrtment of Pulmonary Medicine, Fukushima Medical University School of Medicine, Japan 520

PE32-10 Oral corticosteroid could be a risk factor for diabetes in patients with asthma Yasuhiro Tomita1,2）, Yuma Fukutomi2）, Mari Irie3）, Kazuhiro Azekawa4）, Yoichi Nakamura5）, Chiharu Okada6）, Terufumi Shimoda7）, Miku Kuriki1）, Katsuyuki Kojima1）, Masami Taniguchi2） Respiratory Medicine, Tokai Central Hospital, Japan1）; Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Japan2）; Nihon Medical Insurance Institute Ltd., Japan3）; MHI Co., Ltd., Japan4）; Medical Center for Allergic and Immune Diseases, Yokohama City Minato Red Cross Hospital, Japan5）; Headquarters, National Hospital Organization, Japan6）; Clinical Research Center, National Hospital Organization Fukuoka Hospital, Japan7） PE32-11 Efficacy and safety of once-daily, single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus FF/VI in Japanese patients with inadequately controlled asthma: the CAPTAIN study Yoichi Nakamura1）, Soichiro Hozawa2）, Hironori Sagara3）, Hiroyuki Ohbayashi4）, Andrew Fowler5）, Laurie Lee6）, Jodie Crawford5）, Jun Tamaoki7） Medical Center for Allergic and Immune Diseases Yokohama City Minato Red Cross Hospital, Japan1）; Hiroshima Allergy and Respiratory Clinic, Japan2）; Showa University School of Medicine, Japan3）; Tohno Chuo Clinic, Japan4）; GSK, UK5）; GSK, USA6）; GSK, Japan7） PE32-12 Adrenal insufficiency (AI) as an underestimated risk factor in severe asthma Michiko Haida1）, Katsutoshi Ogawa2）, Akihiko Hashiguchi3）, Takahiro Inoue1） Hanzoumon Hospital, Japan1）; Amica Lifesience, Japan2）; Biomedical Laboratory, Japan3） PE32-13 Comparison of combinations of ICS, LABA, and LAMA as triple agent in patients with BA, COPD, and ACO patients Taichi Mochizuki, Yasushi Inoue, Ryuta Ueda, Hiroyuki Arai, Yasuo To, Seisuke Nagase, Akira Umeda, Kenji Tsushima Department of Respiratory Medicine, School of Medicine, International Medical Welfare University, Tokyo, Japan

Poster Session 33

Treatment for adult asthma 2 PE33-1 Stratification by blood eosinophil counts and levels of fractional exhaled nitric oxide characterizes subclasses of patients with severe asthma Hidetoshi Iemura1,2）, Tomoyuki Soma1,2）, Erika Naito1,2）, Yuki Hoshino1,2）, Sachiko Miyauchi1,2）, Kazuki Katayama1,2）, Ryu Sekiya1,2）, Yoshitaka Uchida1,2）, Kazuyuki Nakagome1,2）, Makoto Nagata1,2） Department of Respiratory Medicine, Saitama Medical University, Japan1）; Allergy Center, Saitama Medical University, Japan2） PE33-2 The analysis of Tfh/Tfr cells and house dust mite (HDM)-specific immunoglobulins in patients with atopic asthma comorbid with allergic rhinitis receiving HDM-sublingual immunotherapy Katsunori Shigehara, Ryuta Kamekura, Shingo Ichimiya Department of Human Immunolgy, Research Institute for Frontier Medicine, Sapporo Medical University, Japan PE33-3 Transcriptome analysis of patients with refractory asthma for predicting the efficacy of bronchial thermoplasty Satoshi Ano1）, Norihiro Kikuchi1）, Masashi Matsuyama2）, Masayuki Nakajima2）, Yuzuru Kondo3）, Michiko Masuda1）, Shizuka Arai1）, Hajime Osawa2）, Yukio Ishii1,2）, Nobuyuki Hizawa2） Department of Respiratory Medicine, National Hospital Organization Kasumigaura Medical Center, Japan1）; Department of Respiratory Medicine, University of Tsukuba, Japan2）; Department of Diagnostic Pathology, National Hospital Organization Kasumigaura Medical Center, Japan3） PE33-4 Investigation of the relationship between serum TSLP levels and other cytokines and patient background in adults with asthma Yamamoto Mayumi, Tomoko Kawahara, Hatsuko Mikuni, Haruna Sato, Tomoki Uno, Yoshitaka Uchida, Yousuke Fukuda, Tomoyuki Kimura, Megumi Jinno, Kuniaki Hirai, Yoshito Miyata, Shin Ohta, Hideki Inoue, Tetsuya Homma, Yoshio Watanabe, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara Division of Respiratory Medicine and Allergology, Showa University Hospital, Japan PE33-5 Changes of the clinical and serum biomarkers after anti-IL5 treatment in patients with severe eosinophilic asthma JaeHyuk Jang, Young-Soo Lee, Seong-Dae Woo, Eun-Mi Yang, Yoo-Sub Shin, Young-Min Ye, Hae-Sim Park

otrSession Poster Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Republic of Korea PE33-6 The effectiveness and safety of one-year use of benralizumab in 19 Japanese patients with severe asthma in clinical practice Takashi Katsuno, Motoyasu Iikura, Junko Terada, Satoshi Ishi, Eriko Morino, Manabu Suzuki, Shinyu Izumi, Masayuki Hojo, Haruhito Sugiyama Respiratory Medicine, National Center for Global Health and Medicine, Japan PE33-7 Omalizumab to prevent exacerbations in children and adolescents with moderate-to-severe allergic asthma: an overview of systematic reviews Xin Zhang, Litao Huang, Yuhui Zhang, Huayang Zhang, Ye Feng Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, China PE33-8 Clinical experience of the use of mepolizumab in treatment of severe asthma Ekaterini Syrigou1）, Maria Tsami1）, Fotis Psarros2）, Konstantinos Syrigos3） Department of Allergy and Clinical Immunology, Sotiria General Hospital of Athens, Greece1）; Department of Allergy, Naval Hospital of Athens, Greece2）; 3rd Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Greece3） PE33-9 Pretreatment serum allergen-specific IgE and omalizumab responsiveness in severe allergic asthma Tomoko Tajiri, Yoshihiro Kanemitsu, Hirono Nishiyama, Ryota Kurokawa, Norihisa Takeda, Kensuke Fukumitsu, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Masaya Takemura, Akio Niimi Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University, Graduate School of Medical Sciences, Japan PE33-10 Three-year outcomes after bronchial thermoplasty for severe uncontrolled asthmatic patients Motoyasu Iikura, Keita Sakamoto, Masao Hashimoto, Satoru Ishii, Shinyu Izumi, Masayuki Hojo, Haruhito Sugiyama Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan PE33-11 Effect of dupilumab on severe asthma exacerbations in patients with oral corticosteroid-dependent severe asthma with and without improvements in lung function Michel Djandji1）, Kazuhiko Arima2）, Masanori Miyata2）, Nicola A Hanania3）, Mario Castro4）, Nadia Daizadeh1）, Benjamin Ortiz5） Sanofi U.S., USA1）; Sanofi K.K., Japan2）; Baylor College of Medicine, USA3）; University of Kansas School of Medicine, USA4）; Regeneron Pharmaceuticals, Inc., USA5） 521

PE33-12 Treatment effects and safety of bronchial thermoplasty based on multicenter research in Japan Akihiro Takemasa1）, Nobuhiko Uchida1）, Yusuke Nakamura1）, Kazuyuki Chibana1）, Yasuo Shimizu1）, Tamotsu Ishizuka2）, Ken Ohta3）, Haruhito Sugiyama4）, Akio Niimi5）, Tomohisa Baba6）, Masamichi Mineshita7） Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Japan1）; Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui Respiratory Disease Center, Japan2）; Fukujuji Hospital, Japan Anti-Tuberculosis Association, Japan3）; Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan4）; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Japan5）; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan6）; Division of Respiratory Diseases, Department of Internal Medicine, St. Marianna University School of Medicine, Japan7） PE33-13 The relationship between the effectiveness of anti-IL-5 antibodies and mucous plugs in severe asthma Satoshi Marumo, Yusuke Hayashi, Yusuke Shiraishi, Takamasa Kitajima, Daiki Inoue, Motonari Fukui Department of Respiratory Medicine, Kitano Hospital, Japan PE33-14 Biological agents for severe asthma: a retrospective study of clinical utility and safety from real-world experience Seigo Katakura1）, Nobuaki Kobayashi1）, Wataru Hashimoto1）, Katushi Tanaka1）, Ryo Nagasawa1）,KoChin1）, Ayako Aoki1）, Kentaro Nakashima1）, Shuhei Teranishi1）, Hiroki Watanabe1）, Keisuke Watanabe1）, Yu Hara1）, Masaki Yamamoto2）, Makoto Kudo2）, Takeshi Kaneko1） Department of Pulmonology, Yokohama City University Graduate School of Medicine, Japan1）; Respiratory Disease Center, Yokohama City University Medical Center, Japan2） PE33-15 Clinical features and effects of biologic agents for severe asthma Kaori Okayasu1）, Harumi Sano2）, Natsumi Asao2）, Koki Hata2）, Toshihisa Ishikawa2）, Reina Imase2）, Juri Honda2）, Tsutomu Kawasaki2）, Yukiko Yamashita3）, Naoto Watanabe1）, Yoichi Nakamura1）, Yasunari Miyazaki4） Medical Center for Allergic and Immune Diseases, Yokohama City Minato Red Cross Hospital, Japan1）; Department of Respiratory Medicine, Yokohama City Minato Red Cross Hospital, Japan2）; Department of Otorhinolaryngology, Yokohama City Minato Red Cross Hospital, Japan3）; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan4） PE33-16 Effectiveness and safety of dupilumab for severe asthmatic patients in clinical practice Motoyasu Iikura, Junko Hirashima, Shinyu Izumi, Masayuki Hojo, Haruhito Sugiyama Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan PE33-17 Mepolizumab 100 mg/4 weeks as a maintenance therapy in patients affected by EGPA and severe steroid-dependent asthma with systemic vasculitis in remission phase Marco Caminati1）, Alessandro Giollo2）, Giovanni Orsolini2）, Giuliana Festi3）, Claudio Micheletto3）, Matteo Maule4）, Claudio Lunardi4）, Gianenrico Senna1） Department of Medicine, University of Verona; Allergy Unit and Asthma Center, Verona University Hospital, Italy1）; Division of Rheumatology, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Italy2）; Cardio-Thoracic Department, Respiratory Unit, Integrated University Hospital, Italy3）; Department of Medicine, University of Verona, Italy4） PE33-18 Atopic iper-IgE patient treated with monoclonal anti-IL4/IL13: an endotype-driven approach Vincenzo Patella1）, Raffaele Brancaccio1,2）, Giovanni Florio1）, Gabriele Delfino1） Division of Allergy and Clinical Immunology, Department of Medicine ASL Salerno, Santa Maria della Speranza Hospital, Italy1）; Postgraduate Program in Allergy and Clinical Immunology, University of Naples Federico II, Italy2） otrSession Poster