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Annual Review 2004 ANNUAL REVIEW 2004 The Wellcome Trust is an independent research-funding charity, established under the will of Sir Henry Wellcome in 1936. It is funded from a private endowment, which is managed with long-term stability and growth in mind. Its mission is to foster and promote research with the aim of improving human and animal health. Its work covers four areas: Knowledge – improving our understanding of human and animal biology in health and disease, and of the past and present role of medicine in society. Resources – providing exceptional researchers with the infrastructural and career support they need to fulfil their potential. Translation – ensuring maximum health benefits are gained from biomedical research. Public engagement – raising awareness of the medical, ethical and social implications of biomedical science. www.wellcome.ac.uk CONTENTS 1 THE WELLCOME TRUST An independent, privately owned endowed medical research charity. Our mission is to foster and promote research with the aim of improving human and animal health. CONTENTS AIMS AND OBJECTIVES BOARD OF GOVERNORS EXECUTIVE BOARD 2 Director’s statement Our four Aims identify the priorities 20 Translation Sir Dominic Cadbury Dr Mark Walport on which we concentrate. Each Advancing the translation Chairman Director of the Wellcome Trust Aim is underpinned by a series of Trust-funded research into health benefits. 4 Knowledge of Objectives which establish Professor Martin Bobrow Linda Arter 14 Resources the practical measures being taken • Promoting patient-orientated Deputy Chairman Director of Finance to achieve the Aims and, ultimately, and health services research. and Information Management 20 Translation our mission. Professor Adrian Bird • Advancing the dissemination 28 Public engagement Dr Ted Bianco 4 Knowledge and exploitation of the results Professor Christopher Edwards Director of Technology Transfer of Trust-funded research. Advancing knowledge and 34 A year at the Wellcome Trust understanding in the biomedical 28 Public engagement Alastair Ross Goobey John Cooper 36 Financial summary sciences and their impact on Engaging with the public Director of Human Resources 37 The funding year society – past, present and future. through informed dialogue. Dame Patricia Hodgson and Services 38 Immunology and Infectious Disease • Stimulating an informed • Supporting basic, applied dialogue to raise awareness Professor Ronald Plasterk Dr David Lynn 40 Molecules, Genes and Cells and strategically important and understanding of biomedical Head of Strategic Planning and Policy 42 Neuroscience and Mental Health research in biomedical sciences. science, its achievements, Professor Peter Smith Clare Matterson 43 Physiological Sciences applications and implications. • Researching the societal Professor Dame Jean Thomas Director of Medicine, Society 44 Populations and Public Health impact of biomedical science – and History 45 Medical Humanities past, present and future. Edward Walker-Arnott 46 Technology Transfer David Phillipps 14 Resources Director Designate of Finance 47 Wellcome Trust Genome Campus Contributing to a long-term and vibrant research environment. 48 Public Engagement Dr Sohaila Rastan 50 Funding committees • Human resources: meeting Director of Science Funding training and career development needs of researchers. John Stewart Head of Legal and Company Secretary This Annual Review covers the Wellcome • Physical resources: building Trust’s financial year 1 October 2003 to suitable conditions for research. 30 September 2004. As at January 2005 L to R The bacterium, A portrait of twins Escherichia coli. by David Teplica. Kenyan child. Interactive exhibit Human embryo at the science centre, at the blastocyst stage. Thinktank, in Birmingham. CONTENTS 1 THE WELLCOME TRUST An independent, privately owned endowed medical research charity. Our mission is to foster and promote research with the aim of improving human and animal health. CONTENTS AIMS AND OBJECTIVES BOARD OF GOVERNORS EXECUTIVE BOARD 2 Director’s statement Our four Aims identify the priorities 20 Translation Sir Dominic Cadbury Dr Mark Walport on which we concentrate. Each Advancing the translation Chairman Director of the Wellcome Trust Aim is underpinned by a series of Trust-funded research into health benefits. 4 Knowledge of Objectives which establish Professor Martin Bobrow Linda Arter 14 Resources the practical measures being taken • Promoting patient-orientated Deputy Chairman Director of Finance to achieve the Aims and, ultimately, and health services research. and Information Management 20 Translation our mission. Professor Adrian Bird • Advancing the dissemination 28 Public engagement Dr Ted Bianco 4 Knowledge and exploitation of the results Professor Christopher Edwards Director of Technology Transfer of Trust-funded research. Advancing knowledge and 34 A year at the Wellcome Trust understanding in the biomedical 28 Public engagement Alastair Ross Goobey John Cooper 36 Financial summary sciences and their impact on Engaging with the public Director of Human Resources 37 The funding year society – past, present and future. through informed dialogue. Dame Patricia Hodgson and Services 38 Immunology and Infectious Disease • Stimulating an informed • Supporting basic, applied dialogue to raise awareness Professor Ronald Plasterk Dr David Lynn 40 Molecules, Genes and Cells and strategically important and understanding of biomedical Head of Strategic Planning and Policy 42 Neuroscience and Mental Health research in biomedical sciences. science, its achievements, Professor Peter Smith Clare Matterson 43 Physiological Sciences applications and implications. • Researching the societal Professor Dame Jean Thomas Director of Medicine, Society 44 Populations and Public Health impact of biomedical science – and History 45 Medical Humanities past, present and future. Edward Walker-Arnott 46 Technology Transfer David Phillipps 14 Resources Director Designate of Finance 47 Wellcome Trust Genome Campus Contributing to a long-term and vibrant research environment. 48 Public Engagement Dr Sohaila Rastan 50 Funding committees • Human resources: meeting Director of Science Funding training and career development needs of researchers. John Stewart Head of Legal and Company Secretary This Annual Review covers the Wellcome • Physical resources: building Trust’s financial year 1 October 2003 to suitable conditions for research. 30 September 2004. As at January 2005 L to R The bacterium, A portrait of twins Escherichia coli. by David Teplica. Kenyan child. Interactive exhibit Human embryo at the science centre, at the blastocyst stage. Thinktank, in Birmingham. DIRECTOR’S STATEMENT DIRECTOR’S STATEMENT 2 3 WORKING WITH OTHERS It’s been a year when working in partnership has delivered real benefits. Highlights of the year • A biochemical defect causing • Avian flu victims are treated • A trial with steroids markedly neonatal diabetes is identified, at Wellcome-funded facilities cuts deaths from tuberculous • The highly accurate and complete allowing babies to be given in Vietnam, capturing valuable meningitis in Vietnam. ‘gold standard’ human genome medication rather than injections. data on the impact of the virus. sequence is released. • ‘Myskin’, an innovative dressing • Beneficial effects of rapamycin • Analysis of clinical trials data incorporating patients’ own cells, • Mutations in the ERBB2 gene analogues in models of for artemisinin combination is launched in the UK NHS. are discovered in a subset of lung Huntington’s disease suggest therapy confirms its potency cancers, opening up the prospect a new therapeutic approach. as an antimalarial drug. • Pain exhibition at the Science of targeted therapy. Museum attracts a record number of visitors. Looking back on a busy year, I am City, which I had the honour of accepting enables us – and, indeed, requires us – funders, including the Department for This year has seen many exciting of our desire to engage with our delighted at the progress we have seen for the Trust during a fascinating visit to play an important role as a critic of International Development, how we research findings published. A small multitude of stakeholder communities. – the discoveries our researchers have to see the work of our researchers Government when it pursues policies might best work together. Moreover, selection of these are summarised Our new corporate identity similarly made, the accelerating application in Thailand, Vietnam and Laos. Professor that may have an adverse impact on with the UK assuming presidency of the in the following pages. It is clear we reflects a desire to be seen as of research, and the changes we have White and Dr Jeremy Farrar were also biomedical research for public good. G8 group of nations on 1 January 2005, are living in a golden age of biomedical approachable, as well as distinctive made within the Wellcome Trust itself. honoured by the Committee. This We have worked very hard during the and a spotlight on Africa as a major research, as human genome data and and independently minded. And I am also pleased that so much recognition is an endorsement of our year to gain acceptance of amendments priority, we have a real opportunity high-throughput technologies offer has been achieved in partnership with long-standing collaborative approach of proposed legislation that could to make a difference to a continent that experimental possibilities undreamed All these strands will come together in others. I firmly believe that scientific in the region. have
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