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Drug Class Review Antianginal Agents
Drug Class Review Antianginal Agents 24:12.08 Nitrates and Nitrites 24:04.92 Cardiac Drugs, Miscellaneous Amyl Nitrite Isosorbide Dinitrate (IsoDitrate ER®, others) Isosorbide Mononitrate (Imdur®) Nitroglycerin (Minitran®, Nitrostat®, others) Ranolazine (Ranexa®) Final Report May 2015 Review prepared by: Melissa Archer, PharmD, Clinical Pharmacist Carin Steinvoort, PharmD, Clinical Pharmacist Gary Oderda, PharmD, MPH, Professor University of Utah College of Pharmacy Copyright © 2015 by University of Utah College of Pharmacy Salt Lake City, Utah. All rights reserved. Table of Contents Executive Summary ......................................................................................................................... 3 Introduction .................................................................................................................................... 4 Table 1. Antianginal Therapies .............................................................................................. 4 Table 2. Summary of Agents .................................................................................................. 5 Disease Overview ........................................................................................................................ 8 Table 3. Summary of Current Clinical Practice Guidelines .................................................... 9 Pharmacology ............................................................................................................................... 10 Table 4. Pharmacokinetic Properties -
Department of Pharmacology
“A STUDY TO EXPLORE THE WEIGHT REDUCING PROPERTY OF DOLICHOS BIFLORUS AND METFORMIN USING OBESE RAT MODEL - MECHANISTIC STUDY” DISSERTATION SUBMITTED FOR M.D. PHARMACOLOGY THE TAMILNADU DR. M.G.R. MEDICAL UNIVERSITY DEPARTMENT OF PHARMACOLOGY PSG INSTITUTE OF MEDICAL SCIENCES AND RESEARCH PEELAMEDU, COIMBATORE – 641004 TAMILNADU, INDIA MAY 2019 PSG INSTITUTE OF MEDICAL SCIENCES & RESEARCH COIMBATORE CERTIFICATE This is to certify that this dissertation entitled “A study to explore the weight reducing property of Dolichos Biflorus and Metformin using obese rat model- mechanistic study” by Dr. P. Mary Mala, is a work done by her during the period of study in the Department of Pharmacology from June 2016 to May 2019, under the guidance of Dr.K.Bhuvaneswari, M.D.PGDBE, Professor & HOD, Department of Pharmacology, PSG IMS&R. Dr.K.Bhuvaneswari M.D.,PGDBE Professor & HOD Department of Pharmacology PSG Institute of Medical Sciences & Research Coimbatore-04 Dr.S.Ramalingam M.D. Dean PSG Institute of Medical Sciences & Research Coimbatore-04 DECLARATION BY THE CANDIDATE I hereby declare that this dissertation entitled, “A study to explore the weight reducing property of Dolichos Biflorus and Metformin using obese rat model- mechanistic study”, is a bonafide work done by me under the guidance and supervision of Dr.K.Bhuvaneswari, HOD & Professor, Department of Pharmacology, PSG Institute of Medical Sciences & Research. This study was conducted at the PSG Institute of Medical Sciences & Research, Coimbatore, under the aegis of The Tamilnadu Dr.MGR Medical University, Chennai, as part of the requirement for the award of M.D. Degree in Pharmacology. Dr.Mary Mala.P, III Year postgraduate, Department of Pharmacology, PSG Institute of Medical Sciences & Research Coimbatore-04 CERTIFICATE This is to certify that this dissertation work titled “A study to explore the weight reducing property of Dolichos biflorus and Metformin using obese rat model- mechanistic study”, of the candidate Dr.Mary Mala.P with registration Number 201616302 for the award of M.D. -
(12) Patent Application Publication (10) Pub. No.: US 2012/0022039 A1 Schwink Et Al
US 20120022039A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0022039 A1 Schwink et al. (43) Pub. Date: Jan. 26, 2012 (54) NOVEL SUBSTITUTED INDANES, METHOD Publication Classification FOR THE PRODUCTION THEREOF, AND USE (51) Int. Cl. THEREOF AS DRUGS A 6LX 3L/397 (2006.01) C07D 207/06 (2006.01) C07D 2L/22 (2006.01) C07D 22.3/04 (2006.01) (75) Inventors: Lothar Schwink, Frankfurt am C07D 22L/22 (2006.01) Main (DE); Siegfried Stengelin, C07C 235/54 (2006.01) Frankfurt am Main (DE); Matthias C07D 307/14 (2006.01) Gossel, Frankfurt am Main (DE); A63L/35 (2006.01) Klaus Wirth, Frankfurt am Main A6II 3/40 (2006.01) (DE) A6II 3/445 (2006.01) A6II 3/55 (2006.01) A63L/439 (2006.01) A6II 3/66 (2006.01) (73) Assignee: SANOFI, Paris (FR) A6II 3/34 (2006.01) A6IP3/10 (2006.01) A6IP3/04 (2006.01) A6IP3/06 (2006.01) (21) Appl. No.: 13/201410 A6IPL/I6 (2006.01) A6IP3/00 (2006.01) C07D 309/04 (2006.01) (52) U.S. Cl. .................... 514/210.01; 549/426: 548/578; (22) PCT Filed: Feb. 12, 2010 546/205; 540/484; 546/112:564/176; 549/494; 514/459:514/408: 514/319; 514/212.01; 514/299; 514/622:514/471 (86). PCT No.: PCT/EP2010/051796 (57) ABSTRACT The invention relates to substituted indanes and derivatives S371 (c)(1), thereof, to physiologically acceptable salts and physiologi (2), (4) Date: Oct. 4, 2011 cally functional derivatives thereof, to the production thereof, to drugs containing at least one substituted indane according (30) Foreign Application Priority Data to the invention or derivative thereof, and to the use of the Substituted indanes according to the invention and to deriva Feb. -
Leeds Thesis Template
System Interactions in the Regulation of Appetite University of Leeds Fiona Louise Wright BSc (Hons) Submitted in accordance with the requirements of the degree of Doctor of Philosophy The University of Leeds Institute of Psychological Sciences September 2013 ii The candidate confirms that the work submitted is her own, except where work which has formed part of jointly-authored publications has been included. The contribution of the candidate and the other authors to this work has been explicitly indicated below. The candidate confirms that appropriate credit has been given within the thesis where reference has been made to the work of others. (see page xxii) This copy has been supplied on the understanding that it is copyright material and that no quotation from the thesis may be published without proper acknowledgement © 2013 The University of Leeds and Fiona Louise Wright iii Acknowledgements First and foremost, I would like to sincerely thank Professor John Rodgers, my PhD supervisor. I could never give enough thanks for his guidance and support over the last four years. He is a truly wonderful supervisor, and his professional knowledge and skill has been continually inspiring. A thank you, as well, to my secondary supervisor, Amanda Harrison, for her supervision and encouragement during John’s absence at the start of this journey. Lisa Broadhead also deserves a special thank you for her company and help in the laboratory during the experimental parts of the thesis. I’d also like to acknowledge Neil Lowley for his wonderful technical help down in the lab. To my funding body, my parents, I owe more thanks than can be put into words. -
Investigation of Orlistat As an Intervention for Obesity and Cardiovascular Risk Factors: a Systematic Review
Investigation of Orlistat as an intervention for obesity and cardiovascular risk factors: A systematic review Item Type Thesis or dissertation Authors Wrigley, Daniel K. Publisher University of Chester Download date 01/10/2021 07:35:59 Link to Item http://hdl.handle.net/10034/125056 This work has been submitted to ChesterRep – the University of Chester’s online research repository http://chesterrep.openrepository.com Author(s): Daniel K Wrigley Title: Investigation of Orlistat as an intervention for obesity and cardiovascular risk factors: A systematic review Date: November 2010 Originally published as: University of Chester MSc dissertation Example citation: Wrigley, D. K. (2010). Investigation of Orlistat as an intervention for obesity and cardiovascular risk factors: A systematic review. (Unpublished master’s thesis). University of Chester, United Kingdom. Version of item: Submitted version Available at: http://hdl.handle.net/10034/125056 Investigation of Orlistat as an Intervention for Obesity and Cardiovascular Risk Factors: A Systematic Review Daniel. K. Wrigley Acknowledgements I would like to acknowledge and thank Dr. Stephen Fallows for the support and guidance on how to construct and finalise my research project. Without his support, assistance, and supervision, this review would have been extremely difficult to complete. I would also like to acknowledge Dr. John Buckley, Mike Morris, and the administration team in the CENS department at the University of Chester, for their support and patience throughout the entirety of my masters degree. I would like to express my utmost gratitude to my father, Alan Wrigley, my mother, Sandra Kesteven, and grand-parents, Sheila and Kenneth Flintham, for their moral and financial support, without which my continuation into further education and the completion of this review would not have been possible. -
Free PDF Download
European Review for Medical and Pharmacological Sciences 2012; 16: 1611-1636 The patient with chronic ischemic heart disease. Role of ranolazine in the management of stable angina A. DI MONACO, A. SESTITO Department of Cardiology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy Abstract. – Ischemic heart disease (IHD) is a serve is exhausted2. Symptom severity can be major cause of death in Western Countries and modulated by dynamic vasomotion at the site of accounts for very high costs worldwide. In this re- stenoses and/or by coronary microvascular dys- view we discussed the pathogenesis, symptoms, 1,2 diagnosis, prognosis and management of chronic function . IHD. In particular, we discussed about the percu- In microvascular angina transient myocardial taneous coronary interventions and coronary ischemia is caused by coronary microvascular artery bypass grafting, as well as to clinical trials dysfunction in patients with angiographically that evaluated the advantages of one approach normal epicardial coronary arteries, in the ab- versus another. Pharmacological treatment is 3,4 among major objectives of the review and for sence of any other specific cardiac disease . In each class of therapeutic agents an evaluation of vasospastic angina transient myocardial is- well-conducted clinical trials is provided. The chemia is caused by coronary spasm5. most important drug classes in IHD treatment are Furthermore, angina and transient myocardial betablockers, calcium channel blockers, nitrates, ischemia may also occur in patients with non ath- antiplatelet agents, and ACE-inhibitors. In addition to these agents, also new treatment options are erosclerotic obstructive coronary artery disease, evaluated in patients with stable IHD. -
(12) United States Patent (10) Patent No.: US 8,080,578 B2 Liggett Et Al
USO08080578B2 (12) United States Patent (10) Patent No.: US 8,080,578 B2 Liggett et al. (45) Date of Patent: *Dec. 20, 2011 (54) METHODS FOR TREATMENT WITH 5,998.458. A 12/1999 Bristow ........................ 514,392 BUCNDOLOL BASED ON GENETIC 6,004,744. A 12/1999 Goelet et al. ...... 435/5 6,013,431 A 1/2000 Söderlund et al. 435/5 TARGETING 6,156,503 A 12/2000 Drazen et al. ..... ... 435/6 6,221,851 B1 4/2001 Feldman ... 51446 (75) Inventors: Stephen B. Liggett, Clarksville, MD 6,316,188 B1 1 1/2001 Yan et al. .......................... 435/6 6,365,618 B1 4/2002 Swartz ... 514,411 (US); Michael Bristow, Englewood, CO 6,498,009 B1 12/2002 Liggett ............................. 435/6 (US) 6,566,101 B1 5/2003 Shuber et al. 435,912 6,586,183 B2 7/2003 Drysdale et al. .................. 435/6 (73) Assignee: The Regents of the University of 6,784, 177 B2 8/2004 Cohn et al. 514,248 Colorado, a body corporate, Denver, 6,797.472 B1 9/2004 Liggett ......... ... 435/6 6,821,724 B1 1 1/2004 Mittman et al. ... 435/6 CO (US) 6,861.217 B1 3/2005 Liggett ......... ... 435/6 7,041,810 B2 5/2006 Small et al. ... ... 435/6 (*) Notice: Subject to any disclaimer, the term of this 7, 195,873 B2 3/2007 Fligheddu et al. ... 435/6 patent is extended or adjusted under 35 7,211,386 B2 5/2007 Small et al. ....... ... 435/6 7,229,756 B1 6/2007 Small et al. -
Calcium Channel Blockers in Cardiovascular Pharmacotherapy
Cardiovascular Pharmacology Core Review Journal of Cardiovascular Pharmacology and Therapeutics 2014, Vol. 19(6) 501-515 Calcium Channel Blockers in ª The Author(s) 2014 Reprints and permission: Cardiovascular Pharmacotherapy sagepub.com/journalsPermissions.nav DOI: 10.1177/1074248414530508 cpt.sagepub.com Theophile Godfraind1 Abstract This paper summarizes the pharmacological properties of calcium channel blockers (CCBs), their established therapeutic uses for cardiovascular disorders and the current improvement of their clinical effects through drug combinations. Their identification resulted from study of small molecules including coronary dilators, which were named calcium antagonists. Further experiments showed that they reduced contraction of arteries by inhibiting calcium entry and by interacting with binding sites identified on voltage-dependent calcium channels. This led to the denomination calcium channel blockers. In short-term studies, by decreasing total peripheral resistance, CCBs lower arterial pressure. By unloading the heart and increasing coronary blood flow, CCBs improve myocardial oxygenation. In long-term treatment, the decrease in blood pressure is more pronounced in hypertensive than in normotensive patients. A controversy on the safety of CCBs ended after a large antihypertensive trial (ALLHAT) sponsored by the National Heart, Lung, and Blood Institute. There are two main types of CCBs: dihydopyridine and non-dihydropyridine; the first type is vascular selective. Dihydropyrines are indicated for hypertension, chronic, stable and vasospastic angina. Non-dihydropyridines have the same indications plus antiarrythmic effects in atrial fibrillation or flutter and paroxysmal supraventricular tachycardia. In addition, CCBs reduced newly formed coronary lesions in atherosclerosis. In order to reach recommended blood pressure goals, there is a recent therapeutic move by combination of CCBs with other antihypertensive agents particularly with inhibitors acting at the level of the renin-angiotensin system. -
Medcompgx Med List
For more info, go to: MedCompGx.com Medications Conditions / Uses Other Uses CYP2C19 Anticonvulsants Lacosamide (Vimpat) Epilepsy, Seizures Phenobarbital (Luminal) Epilepsy, Seizures Barbituates, Anxiety, Sedation, Withdrawl Primidone (Mysoline) Epilepsy, Seizures Zonisamide (Zonegran) Epilepsy, Seizures Antifungals Voriconazole (Vfend) Yeast Infections, Candidiasis, Aspergillosis, Candida, Aspergillus Antidepressants Escitalopram (Lexapro) SSRI, Depression, Anxiety Citalopram (Celexa) SSRI, Depression, Anxiety OCD Sertraline (Zoloft) SSRI, Depression, Anxiety OCD, PTSD Doxepin (Silenor) Tricyclic Antidepressant, Depression Bipolar, Insomnia Imipramine (Tofranil) Tricyclic Antidepressant, Depression Trimipramine (Surmontil) Tricyclic Antidepressant, Depression Amitriptyline (Elavil) Tricyclic Antidepressant, Depression Clomipramine (Anafranil) Tricyclic Antidepressant, Depression OCD Benzodiazepines Clobazam (Onfi) Seizures Diazepam (Valium) Seizures, Muscle Spasms, Anxiety, Alcohol Withdrawl Beta Blockers Labetalol (Normodyne, Trandate) High Blood Pressure, Hypertension Immunomodulators Leflunomide (Arava) Rheumatoid Arthritis Tofacitinib (Xeljanz) Rheumatoid Arthritis Muscle Relaxants Carisoprodol (Soma) Muscle Pain, Muscle Spasms Opioids Meperidine (Demerol) Pain, Severe Pain, Narcotic, Opiate Proton Pump Inhibitors Dexlansoprazole (Dexilant) GERD, Acid Reflux, Gastric Esophageal Reflux, Ulcers, Heartburn, Zollinger-Ellison Syndrome Esomeprazole (Nexium) GERD, Acid Reflux, Gastric Esophageal Reflux, Ulcers, Heartburn, Zollinger-Ellison -
World Health Organization Model List of Essential Medicines, 21St List, 2019
World Health Organizatio n Model List of Essential Medicines 21st List 2019 World Health Organizatio n Model List of Essential Medicines 21st List 2019 WHO/MVP/EMP/IAU/2019.06 © World Health Organization 2019 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. World Health Organization Model List of Essential Medicines, 21st List, 2019. Geneva: World Health Organization; 2019. Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data. CIP data are available at http://apps.who.int/iris. -
(12) United States Patent (10) Patent No.: US 9,365,521 B2 Blackburn Et Al
USOO9365521B2 (12) United States Patent (10) Patent No.: US 9,365,521 B2 Blackburn et al. (45) Date of Patent: Jun. 14, 2016 (54) NON-HYGROSCOPICSALTS OF 5-HT, 5,178,786 A 1/1993 Jahnke et al. AGONSTS 5,247,080 A 9/1993 Berger et al. 5,275,915 A 1/1994 Kojima et al. 5,387,685 A 2f1995 Powell et al. (75) Inventors: Anthony C. Blackburn, San Diego, CA 5,397.793 A 3, 1995 Shaber et al. (US); Yun Shan, San Diego, CA (US); 5,412,119 A 5/1995 Brussee et al. Anna Shifrina, San Diego, CA (US); 5,422,355 A 6/1995 White et al. Scott Stirn, San Diego, CA (US) 5,691.362 A 11/1997 McCormicket al. 5,750,520 A 5/1998 Danilewicz et al. (73) Assignee: Arena Pharmaceuticals, Inc., San 5,856.5035,795,895 A 8,1/1999 1998 AnchAS al. Diego, CA (US) 5,861,393 A 1/1999 Danilewicz et al. 5,908,830 A 6/1999 Smith et al. (*) Notice: Subject to any disclaimer, the term of this 5,925,651 A 7/1999 Hutchinson patent is extended or adjusted under 35 3. A 3: As al U.S.C. 154(b) by 567 days. 5,958,943- 4 A 9/1999 Laufera etca. al. 6,087,346 A 7/2000 Glennon et al. (21) Appl. No.: 13/820,095 6,218,385 B1 4/2001 Adam et al. 6,900,313 B2 5/2005 Wasserscheid et al. (22) PCT Filed: Aug. 31, 2011 6,953,787 B2 * 10/2005 Smith ................. -
Ukrainian Medical Stomatological Academy
Poltava State Medical University Department of Experimental and Clinical Pharmacology Lecture 9 Module 1 MEDICINAL DRUGS INFLUENCING CARDIO-VASCULAR SYSTEM. MEDICINAL DRUGS FOR TREATMENT OF ISCHEMIC HEART DISEASE. HYPOLIPIDEMIC DRUGS. ANGIOPROTECTORS Prepared by Ye.Vazhnichaya [email protected], +380666347273 CONTENTS A. Antianginal drugs 1. Pathogenesis of angina pectoris and ways to its control 2. Classification of the antianginal grugs 3. Drugs that decrease oxygen demand and increase oxygen supply 4. Drugs decreasing oxygen demand of the myocardium 5. Drugs increasing oxygen supply to the myocardium 6. Drugs increasing the myocardium stability to hypoxia B. Antiatherosclerotic drugs 1. Pathogenesis of aherosclerosis and its management 2. Classification of the antiatherosclerotic drugs 3. Hypolipidemic agents 4. Antioxidants 5. Antiplatelets 6. Angioprotectors C. Control tasks ANTIANGINAL DRUGS ISCHEMIC HEART DISEASE Ischemic heart disease Angina Myocardial Myocardial pectoris infarction sclerosis ANGINA PECTORIS Angina pectoris is characterized by a sudden, severe pressing or acute chest pain radiating to the left arm and neck. Anginal pain occurs when the oxygen supply to myocardium is insufficient for its needs. The imbalance between oxygen delivery and utilization may result from a spasm or from obstruction of heart blood vessels. The coronary blood flow is insufficient to meet the heart’s metabolic requirements. It causes the onset of anginal pain. MAIN CAUSES OF ANGINA ATTACK: thrombosis, atherosclerosis and spasm of coronary blood vessels ANTIANGINAL DRUGS: pharmacological management Pharmacological management in angina pectoris includes: Decrease in oxygen demand of myocardium Increase in oxygen supply Changes of myocardium metabolism in favor of stability to oxygen insufficiency. ANTIANGINAL DRUGS: classification A. Drugs that decrease oxygen demand of myocardium and increase oxygen supply 1.