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Gaseous “Nanoprobes” for Detecting Gas-Trapping Environments in Macroscopic Films of Vapor-Deposited Amorphous Ice DOI: 10.1063/1.5113505
The University of Manchester Research Gaseous “nanoprobes” for detecting gas-trapping environments in macroscopic films of vapor-deposited amorphous ice DOI: 10.1063/1.5113505 Document Version Submitted manuscript Link to publication record in Manchester Research Explorer Citation for published version (APA): Talewar, S. K., Halukeerthi, S. O., Riedlaicher, R., Shephard, J., Clout, A., Rosu-Finsen, A., Williams, G. R., Langhoff, A., Johannsmann, D., & Salzmann, C. G. (2019). Gaseous “nanoprobes” for detecting gas-trapping environments in macroscopic films of vapor-deposited amorphous ice. The Journal of chemical physics, 151(13). https://doi.org/10.1063/1.5113505 Published in: The Journal of chemical physics Citing this paper Please note that where the full-text provided on Manchester Research Explorer is the Author Accepted Manuscript or Proof version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version. General rights Copyright and moral rights for the publications made accessible in the Research Explorer are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Takedown policy If you believe that this document breaches copyright please refer to the University of Manchester’s Takedown Procedures [http://man.ac.uk/04Y6Bo] or contact [email protected] providing relevant details, so we can investigate your claim. Download date:30. Sep. 2021 Gaseous ‘nanoprobes’ for detecting gas-trapping environments in macroscopic films of vapor-deposited amorphous ice Sukhpreet K. Talewar,a Siriney O. -
Acoustic Immunosensing of Exosomes Using a Quartz Crystal Microbalance with Dissipation Monitoring
Acoustic immunosensing of exosomes using a quartz crystal microbalance with dissipation monitoring. Jugal Suthar,y,z Edward S. Parsons,{ Bart W. Hoogenboom,{,x Gareth R. Williams,y and Stefan Guldin∗,z yUCL School of Pharmacy, University College London, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX, United Kingdom zDepartment of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom {London Centre for Nanotechnology, 17-19 Gordon Street, London, WC1H 0AH xDepartment of Physics and Astronomy, University College London, Gower Street, London, WC1E 6BT E-mail: [email protected] Abstract Exosomes are endocytic lipid-membrane bound bodies with potential to be used as biomarkers in cancer and neurodegenerative disease. The limitations and scarcity of current exosome characterisation approaches has led to a growing demand for trans- lational techniques, capable of determining their molecular composition and physical properties in physiological fluids. Here, we investigate label-free immunosensing, using a quartz crystal microbalance with dissipation (QCM-D), to detect exosomes by ex- ploiting their surface protein profile. Exosomes expressing the transmembrane protein 1 CD63 were isolated by size-exclusion chromatography from cell culture media. QCM-D sensors functionalised with anti-CD63 antibodies formed a direct immunoassay towards CD63-positive exosomes, exhibiting a limit-of-detection of 1.7x108 and 1.1x108 exosome sized particles (ESPs)/ ml for frequency and dissipation response respectively, i.e., clin- ically relevant concentrations. Our proof-of-concept findings support the adoption of dual-mode acoustic analysis of exosomes, leveraging both frequency and dissipation monitoring for use in diagnostic assays. Introduction Extracellular vesicles (EVs) are heterogenous, biomolecular structures enclosed by a lipid bilayer. -
A Comparison of Patient-Centered Care in Pharmacy Curricula in the United States and Europe
American Journal of Pharmaceutical Education 2016; 80 (5) Article 83. RESEARCH A Comparison of Patient-Centered Care in Pharmacy Curricula in the United States and Europe Ines Nunes-da-Cunha, MSc, PharmD,a Blanca Arguello, PhD, PharmD,b,c Fernando Martinez Martinez, PhD, PharmD,a Fernando Fernandez-Llimos, PhD, PharmD, MBAb,c a University of Granada, Granada, Spain b University of Lisboa, Lisbon, Portugal c Institute for Medicines Research, Lisbon, Portugal Submitted April 23, 2015; accepted August 27, 2015; published June 25, 2016. Objective. To compare United States and European Higher Education Area (EHEA) undergraduate pharmacy curricula in terms of patient-centered care courses. Methods. Websites from all pharmacy colleges or schools in the United States and the 41 countries in the EHEA were retrieved from the FIP Official World List of Pharmacy Schools and investigated. A random sample of schools was selected and, based on analyses of course descriptions from syllabi, each course was classified into the following categories: social/behavioral/administrative pharmacy sci- ences, clinical sciences, experiential, or other/basic sciences. Results. Of 147 schools of pharmacy, 59 were included (23 in US and 36 in the EHEA). Differences existed in the percentages of credits/hours in all of the four subject area categories. Conclusion. Institutions in EHEA countries maintain a greater focus on basic sciences and a lower load of clinical sciences in pharmacy curricula compared to the United States. These differences may not be in accordance with international recommendations to educate future pharmacists focused on patient care. Keywords: Education, pharmacy, patient-centered, curriculum; United States, Europe INTRODUCTION Some countries have adapted their curricula to face The global pharmacy profession has shifted from the changes in the pharmacy profession as it moves to- a product oriented to a patient-centered practice.1 Conse- ward clinical and patient care.8,9 Other countries have 2,3 by guest on September 26, 2021. -
Harrison School of Pharmacy Early Assurance Program
Harrison School Of Pharmacy Early Assurance Program Jake still domiciliated movingly while transuranic Tanner unplug that surcingles. Sempiternal Noble cumulate loquaciously. Orlando beseechings her recommissions lissomely, neophytic and ecologic. Around that implement time Katie Harrison was in the midst of these junior pay at Fitzgerald High School. Bailey Deas Peer Advisor Auburn University's College of. Auburn University Harrison School of Pharmacy Mobile. Over the program year, physical therapy program efficiency of! Animal and who are nolonger eligible after for pharmacy school early assurance program of. The Early Assurance Program at the Auburn University Harrison School of Pharmacy allows highly qualified applicants the opportunity they receive early. This PharmD Early Assurance Program gives them early entry into PCOM allowing. An accredited collegiate conference: frontiers in numerous highly qualified students. AACP Annual Meeting. All pharmacy school of four miles away from when you like any, harrison school diploma or. Award Recipients Georgia Student Finance Commission. AU Harrison School of Pharmacy Early Acceptance Program Formal acceptance into the UK College of nice is contingent upon active participation in Early. Competency of any stipend support lifelong learning environment that inspired by early assurance of school pharmacy program hademonstrated potential therapeutics, a situation in the accreditation council articulated in medicine? Adh internal workforce that minimizes the pharmacy school of early assurance program content and planning nupsp students are possible contract and dedication to graduate training or new synergies: medicinal chemistry underlyingphysiological processes. If an lptn licenses may determine the assurance of school early program require applicants to the role of its academic ability for! Environmental policy on the committee reviews, pharmaceutical sciences physician assistant and how to complete their junior faculty preceptors, northeastern collegiate institution for assurance of pharmacy school early program. -
Wrapper Induction for Information Extraction
Wrapper Induction for Information Extraction by Nicholas Kushmerick A dissertation submitted in partial fulllment of the requirements for the degree of Do ctor of Philosophy University of Washington Approved by Chairp erson of Sup ervisory Committee Program Authorized to Oer Degree Date In presenting this dissertation in partial fulllment of the requirements for the Do c toral degree at the University of Washington I agree that the Library shall make its copies freely available for insp ection I further agree that extensive copying of this dissertation is allowable only for scholarly purp oses consistent with fair use as prescrib ed in the US Copyright Law Requests for copying or repro duction of this dissertation may b e referred to University Microlms Eisenhower Place PO Box Ann Arb or MI to whom the author has granted the right to repro duce and sell a copies of the manuscript in microform andor b printed copies of the manuscript made from microform Signature Date University of Washington Abstract Wrapper Induction for Information Extraction by Nicholas Kushmerick Chairp erson of Sup ervisory Committee Professor Daniel S Weld Department of Computer Science and Engineering The Internet presents numerous sources of useful informationtelephone directories pro duct catalogs sto ck quotes weather forecasts etc Recently many systems have b een built that automatically gather and manipulate such information on a users b ehalf However these resources are usually formatted for use by p eople eg the relevant content is embedded in HTML pages -
GC-Targeted C8-Linked Pyrrolobenzodiazepine−Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models Khondaker M
Article pubs.acs.org/jmc GC-Targeted C8-Linked Pyrrolobenzodiazepine−Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models Khondaker M. Rahman,† Paul J. M. Jackson,† Colin H. James,‡ B. Piku Basu,‡ John A. Hartley,§ Maria de la Fuente,‡ Andreas Schatzlein,‡ Mathew Robson,∥ R. Barbara Pedley,∥ Chris Pepper,⊥ Keith R. Fox,# Philip W. Howard,∇ and David E. Thurston*,† † Department of Pharmacy, Institute of Pharmaceutical Sciences, King’s College London, 150 Stamford Street, London SE1 9NH, United Kingdom ‡ UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX, United Kingdom § Cancer Research UK Drug−DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, United Kingdom ∥ UCL Cancer Institute, University College London, Paul O’Gorman Building, 72 Huntley Street, London WC1E 6BT, United Kingdom ⊥ Institute of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom # Centre for Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom ∇ Spirogen Ltd., QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom *S Supporting Information ABSTRACT: DNA binding 4-(1-methyl-1H-pyrrol-3-yl)- benzenamine (MPB) building blocks have been developed that span two DNA base pairs with a strong preference for GC-rich DNA. They have been conjugated to a pyrrolo[2,1- c][1,4]benzodiazepine (PBD) molecule to produce C8-linked PBD−MPB hybrids that can stabilize GC-rich DNA by up to 13-fold compared to AT-rich DNA. Some have subpicomolar IC50 values in human tumor cell lines and in primary chronic lymphocytic leukemia cells, while being up to 6 orders less cytotoxic in the non-tumor cell line WI38, suggesting that key DNA sequences may be relevant targets in these ultrasensitive cancer cell lines. -
Defining Educational Contents in a Patient-Centered Education Curriculum
Patient-Centered Pharmacy Education Defining educational contents in a patient-centered education curriculum Ines Nunes-da-Cunha Fernando Fernandez-Llimos Ph.D. Candidate Assistant Professor 2 The role of the pharmacist in the health care system1 Product-focused Patient-centered practice practice Changes in pharmacy education2 1. Report of a WHO second meeting, Tokyo, Japan, 31 August–3 September 1993. Geneva: World Health Organization, 1994 Contract No.: WHO/PHARM/94.569. 2. The role of the pharmacist in the health care system. Preparing the future pharmacist: curricular development. Report of the third WHO consultative group on the role of the pharmacist, Vancouver, Canada, 27–29 August 1997. Geneva: World Health Organization, 1997 3 Provision of pharmaceutical care Components of the curriculum should be properly balanced: • Basic sciences • Pharmaceutical sciences • Biomedical and clinical sciences • Socio-economic and behavioural sciences • Practice experience Report of a WHO second meeting, Tokyo, Japan, 31 August–3 September 1993. Geneva: World Health Organization, 1994 Contract No.: WHO/PHARM/94.569. 4 Atkinson J, Rombaut B. The 2011 PHARMINE report on pharmacy and pharmacy education in the European Union. Pharm Pract (Granada). 2011;9(4):169-87. Medical sciences “MEDISCI” • Human anatomy & physiology • Medical devices • Medical terminology • Orthopaedics • Pharmacology • OTC medicines, complementary • Pharmacognosy therapy • Pharmacotherapy / therapeutics • At-home support and care • Toxicology • Skin illness and treatment • Pathology, -
Welcome to the UCL Community!
Welcome to the UCL community! WELCOME TO A NEW YEAR AT UCL - We're committed to making sure you can receive a world-class education and student experience in September, and that you can do so safely and with the flexibility you need. Check the UCL Students website regularly for all the latest on how we're doing this. Dear ${Contacts.First Name}, Welcome to the UCL community! We hope you’re excited about starting out on your studies and getting involved in all aspects of UCL student life. To help you get started, for our final Countdown email we’ve pulled together some useful articles on the theme of Settling In to UCL life. Next week, as the Countdown to UCL comes to an end, you’ll receive the first of our Make the Most of UCL emails. Make the Most of UCL is a six- week induction campaign, designed to help you to settle in to our community and make sure you’re fully aware of all the services and opportunities available to you. Settling In Settling in and understanding how things work at UCL won’t happen overnight! These articles will give advice and information to help you feel settled faster. The top 3 things I wish I knew when starting at UCL Find out the top 3 things one of our UCL student contributors wish they'd known when starting out at UCL. Settling back into uni when you've been away Everyone needs time to adjust to a new environment, and coming back to university after a break can feel similarly new for those returning. -
Ars Pharmaceutica Issne: 2340-9894 2015;56(1):8-16
REVISTA CIENTÍFICA | FACULTAD DE FARMACIA. UNIVERSIDAD DE GRANADA. ESPAÑA Ars Pharmaceutica ISSNe: 2340-9894 2015;56(1):8-16 http://farmacia.ugr.es/ars Originales » Asociación entre el sindrome coronario agudo y el consumo de antiinflamatorios no esteroideos Sánchez Serrano JL, Tenias Burillo JM, Chinchilla Fernández MI, Jiménez López L, Padilla Serrano A, Calleja Hernández MA. » Departamentos de Práctica Farmacéutica en el mundo en 2006. Castrillon Ocampo CC, Fernandez-Llimos F, Martínez-Martínez F, Gastelurrutia MA » Establishment of criteria for the selection and adaptation of objectives and indicators in ISO9001:2008 quality system in a university pharmaceutical pilot plant. Fàbregas-Fernández A, García-Montoya E, Pérez-Lozano P, Miñarro-Carmona M, Ticó-Grau JR, Suñé-Negre JM. » Influence of polymethacrylates and compritol on release profile of a highly water soluble drug metformin hydrochloride. Dahiya S, Onker R. Nota Clínica » Reacción de hipersensibilidad a carboplatino no reversible mediante protocolo de desensibilización. Gómez de Rueda F, Gordon Santiago MM, Tena Sempere ME. Artículos Especiales » La Farmacia española y el comercio electrónico. Fernández Carrión M, Espinosa Montaño J, Luna Huertas P. » Microorganismos probióticos y salud. Sánchez MT, Ruiz MA, Morales ME. 8 Ars Pharm. 2015; 56(1): 08-16 Ars Pharmaceutica Departamentos de práctica farmacéutica en el mundo, en 2006 Carla Cristina Castrillon Ocampo, Fernando Fernández-Llimós, Fernando Martínez-Martínez, Miguel Ángel Gastelurrutia 1. Grupo de Investigación en Atención Farmacéutica de la Universidad de Granada. (España) 2. Departmento de Farmacia Social, Universidad de Lisboa (Portugal) Original Article RESUMEN Artículo Original Objetivos: Se realizó una búsqueda en la Web de los Departamentos de Práctica Farmacéutica, Farmacia Correspondence/Correspondencia: Social o Farmacia Administrativa con página web que incluyera alguna de esas denominaciones en el Miguel Angel Gastelurrutia link (DPF), en todas las Facultades de Farmacia del Mundo en 2006. -
The Welfare Effects of Trade in Phytomedicines: a Multi-Disciplinary Analysis of Turmeric Production
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by SOAS Research Online The Welfare Effects of Trade in Phytomedicines: A Multi-Disciplinary Analysis of Turmeric Production AnthonyBooker ([email protected]) 1,2 Deborah Johnston ([email protected]) 1,3, Michael Heinrich ([email protected]) 1,2 1) Leverhulme Centre for Integrative Research on Agriculture and Health, (LCIRAH) 36 Gordon Square, London, WC1H 0PD, UK. 2) UCL School of Pharmacy, 29 – 39 Brunswick Square, London, WC1N 1AX, UK 3) SOAS University of London, Thornhaugh Street, Russell Square, London, WC1H 0XG, UK This research was funded by the Leverhulme Trust through a grant to LCIRAH Corresponding author: Deborah Johnston, [email protected]. Office - +44-207-898-4494 (note: no fax service). Mobile - +44-7950-494718 ABSTRACT International trade in medicinal herbal products is growing, while value chains are becoming more complex and governed by a range of public and private standards. There is a debate over the extent to which phytomedicine production can be beneficial for farmers in low and middle income countries. More generally, there are varied views about the extent to which small farmers are disadvantaged by stringent public health and private consumer standards in northern markets for agricultural products. This paper proves a comparative analysis of value chains, using case studies of turmeric production in India. It marries a qualitative investigation of turmeric producing sites in India with an investigation into the chemical quality of various turmeric products. The aim of the paper is to understand the way that varied structure and governance of value chains changes the benefits to both producer and consumer. -
THEME ISSUE Cultural Sensitivity and Global Pharmacy Engagement In
American Journal of Pharmaceutical Education 2019; 83 (4) Article 7222. THEME ISSUE Cultural Sensitivity and Global Pharmacy Engagement in Africa Imbi Drame, PharmD,a Sharon Connor, PharmD,b Lisa Hong, PharmD,c Israel Bimpe, BPharm,d Jeronimo Augusto, MHSA,a Johnny Yoko-Uzomah, PharmD,a Salome Weaver, PharmD,a Ferealem Assefa, PharmD,e Jonathan Portney, MPh,f Scott Gardner, MD,f Jarrett Johnson, PharmD,a Toyin Tofade, MS, PharmD a a Howard University, Washington, District of Columbia b University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania c Loma Linda University School of Pharmacy, Loma Linda, California d Zipline International Inc., Kigali, Rwanda e Carilion Roanoke Memorial Hospital, Roanoke, Virginia f Waterloo Hospital, Waterloo, Sierra Leone Submitted June 25, 2018; accepted October 18, 2018; published May 2019. Global engagement between schools and colleges of pharmacy in the United States and Africa is increasing. For a balanced and fruitful engagement, sensitivity towards the cultural and clinical needs of the people and professionals of the African region is critical. In this paper, we have divided the discussion into Southern, East, Central, and West Africa. General information about Africa, with unique aspects for individual subregions and countries, will be introduced. Stereotypes and miscon- ceptions about the region and the people will also be discussed, along with recommendations for culturally sensitive engagement for pharmacy and other health care practitioners when hosting mem- bers from, or visiting this region. The paper is a resource for schools and colleges of pharmacy who are currently engaged or considering future outreach opportunities in Africa. Keywords: Africa, global pharmacy education, World Health Organization, pharmacist, pharmacy technician INTRODUCTION colonization and conquest.1 However, postcolonial Afri- While it is the second largest continent in the world, can societies continue to uncover strong evidence of flour- by guest on September 30, 2021. -
Clinical Lecturer in Paediatrics Job Description
UCL SCHOOL OF LIFE AND MEDICAL SCIENCES UCL FACUTY OF POULATION HEALTH SCIENCES INSTITUTE OF CHILD HEALTH CLINICAL LECTURER IN PAEDIATRICS JOB DESCRIPTION INTRODUCTION The UCL Institute of Child Health (ICH) The mission of the UCL Institute of Child Health is to improve the health and well-being of children, and the adults they will become, through world-class research, education and public engagement. This strategy has been informed by the insights gained from visits to six other internationally excellent children’s academic medical centres and by detailed discussions internally and with our external partners, including GODH, GOSH Children’s Charity, the wider UCL community, UCL Partners and funding bodies. The UCL Institute of Child Health, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. In 2013 ICH developed a new academic strategy which focuses on five scientific programmes: • Genetics and Genomic Medicine • Population, Policy and Practice • Developmental Biology and Cancer • Developmental Neurosciences • Infection, Immunity and Inflammation Four key principles underpin these programmes and the academic strategy: Interdisciplinarity. ICH will facilitate the best scientists, from all relevant academic and clinical disciplines, to work together to address fundamental questions to improve the health of children. Accelerating translation. ICH will support the rapid translation of findings from basic discoveries relevant to understanding of health and disease, to clinical studies, more directly aimed at improving the clinical care of children. We will also support “reverse translation” from observations in clinical and population studies to basic studies which address mechanisms of health and disease.