Medical/Surgical Investigative List Effective
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Overexpression of Cx43 in Cells of the Myocardial Scar
www.nature.com/scientificreports OPEN Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through Received: 27 September 2017 Accepted: 6 April 2018 heterotypic cell-cell coupling Published: xx xx xxxx Wilhelm Roell1, Alexandra M. Klein1,2, Martin Breitbach2, Torsten S. Becker2, Ashish Parikh4, Jane Lee3, Katrin Zimmermann5, Shaun Reining3, Beth Gabris4, Annika Ottersbach1,2, Robert Doran3, Britta Engelbrecht1,2, Miriam Schifer1,2, Kenichi Kimura1,2, Patricia Freitag2, Esther Carls1,2, Caroline Geisen2, Georg D. Duerr1, Philipp Sasse2, Armin Welz1, Alexander Pfeifer5, Guy Salama4, Michael Kotlikof3 & Bernd K. Fleischmann2 Ventricular tachycardia (VT) is the most common and potentially lethal complication following myocardial infarction (MI). Biological correction of the conduction inhomogeneity that underlies re- entry could be a major advance in infarction therapy. As minimal increases in conduction of infarcted tissue markedly infuence VT susceptibility, we reasoned that enhanced propagation of the electrical signal between non-excitable cells within a resolving infarct might comprise a simple means to decrease post-infarction arrhythmia risk. We therefore tested lentivirus-mediated delivery of the gap-junction protein Connexin 43 (Cx43) into acute myocardial lesions. Cx43 was expressed in (myo)fbroblasts and CD45+ cells within the scar and provided prominent and long lasting arrhythmia protection in vivo. Optical mapping of Cx43 injected hearts revealed enhanced conduction velocity within the scar, indicating Cx43-mediated electrical coupling between myocytes and (myo)fbroblasts. Thus, Cx43 gene therapy, by direct in vivo transduction of non-cardiomyocytes, comprises a simple and clinically applicable biological therapy that markedly reduces post-infarction VT. Ventricular tachycardia (VT) is the most common and potentially lethal complication following myocardial infarction (MI)1. -
Computing in Cardiology
COMPUTING IN CARDIOLOGY September 13-16, 2020 Rimini, Italy Table of Contents Sponsors 3 Welcome to CinC@Rimini in 2020! 5 Board of Directors 7 Local Organizing Committee 8 Letter from the President 9 Welcome to Brno for CinC 2021 10 Maps 11 General Map of Rimini 11 Transportation, Hotels and Practical Information 14 Transportation 14 By air 14 By car 14 By train 14 Local Transportation in Rimini 15 By bus 15 By bike 15 Practical Information 16 Climate 16 Money/currency 16 Emergency phone numbers 16 Electric standards 16 Language 17 Time Zones 17 Mobile Phones 17 Safety and Security 17 COVID-19 emergency – Main general rules in Emilia - Romagna 17 COVID-19 emergency – Safety rules and procedures at Palacongressi 18 Internet Access 19 Computing in Cardiology 2020 1 Meals 20 Accompanying Persons (Guests) 20 Conference Information 21 General Information 21 Sunday Symposium 21 Programme outline 21 Conference site 22 Monday Social Program 23 Activist program 23 Passivist program 24 For Authors and Speakers 25 Oral presentations 25 IN PERSON oral presentations 25 REMOTE oral presentations 26 Q&A during oral presentations 26 Poster presentations 26 IN PERSON poster session 26 REMOTE poster session 27 Rosanna Degani Young Investigator Award 28 Clinical Needs Translational (CTA) Award 28 PhysioNet/Computing in Cardiology Challenge 2020 28 Maastricht Simulation Award (MSA) 29 Deadlines 29 Manuscripts 29 Scientific Program Details 31 Program Overview 2 Computing in Cardiology 2020 Sponsors Computing in Cardiology 2020 is supported by several institutions, companies and academic partnerships. The Local Organizing Committee would like to thank the following partners: Computing in Cardiology 2020 3 4 Computing in Cardiology 2020 Welcome to CinC@Rimini in 2020! Dear Colleagues and Friends, On behalf of the Local Organizing Committee, we warmly welcome you to Computing in Cardiology 2020. -
Clinical Guideline Experimental Or Investigational Services
Clinical Guideline Guideline Number: CG012, Ver. 6 Experimental or Investigational Services Disclaimer Clinical guidelines are developed and adopted to establish evidence-based clinical criteria for utilization management decisions. Oscar may delegate utilization management decisions of certain services to third-party delegates, who may develop and adopt their own clinical criteria. Clinical guidelines are applicable to certain plans. Clinical guidelines are applicable to members enrolled in Medicare Advantage plans only if there are no criteria established for the specified service in a Centers for Medicare & Medicaid Services (CMS) national coverage determination (NCD) or local coverage determination (LCD) on the date of a prior authorization request. Services are subject to the terms, conditions, limitations of a member’s policy and applicable state and federal law. Please reference the member’s policy documents (e.g., Certificate/Evidence of Coverage, Schedule of Benefits) or contact Oscar at 855-672-2755 to confirm coverage and benefit conditions. Summary The services referenced in this Clinical Guideline are considered experimental or investigational and are therefore not covered by Oscar. The services referenced in this Clinical Guideline may not be all- inclusive. Specific benefit plan documents (e.g., Certificate of Coverage, Schedule of Benefits) and federal or state mandated health benefits and laws take precedence over this Clinical Guideline. A service considered experimental or investigational when its safety and efficacy has been established. They may have outcomes that are inferior to standard medical treatment, for which long-term clinical utility has been established. To determine whether a service, device, treatment or procedure has proven safety and efficacy, the available reliable evidence is reviewed, which may include but is not limited to (listed in order of decreasing reliability): 1. -
Evaluation of the Optimal Image Reconstruction Interval for Noninvasive Coronary 64-Slice Computed Tomography Venography
Open Journal of Radiology, 2013, 3, 66-72 http://dx.doi.org/10.4236/ojrad.2013.32010 Published Online June 2013 (http://www.scirp.org/journal/ojrad) Evaluation of the Optimal Image Reconstruction Interval for Noninvasive Coronary 64-Slice Computed Tomography Venography Yasutoshi Ohta1, Shinya Fujii1, Suguru Kakite1, Einosuke Mizuta2, Masayuki Hashimoto3, Toshio Kaminou1, Toshihide Ogawa1 1Division of Radiology, Department of Pathophysiological Therapeutic Science, Faculty of Medicine, Tottori University, Yonago City, Japan 2Division of Cardiology, Sanin Rosai Hospital, Yonago City, Japan 3Division of Radiology, Tottori Prefecture Kousei Hospital, Kurayoshi City, Japan Email: [email protected] Received March 22, 2013; revised April 22, 2013; accepted April 30, 2013 Copyright © 2013 Yasutoshi Ohta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Objective: We investigated the appropriate reconstruction interval required to generate optimal quality images of the coronary veins and to evaluate the size of each vein at the systolic and diastolic phases using coronary computed tomo- graphy (CT) venography. Methods: Coronary CT venograms obtained from 30 patients using 64-slice CT were recon- structed at 0% to 90% of the cardiac cycle in 10% increments. Two radiologists assessed the image quality of the ante- rior interventricular vein (AIV), the great cardiac vein (GCV), the posterior vein of the left ventricle (PVLV), the poste- rior interventricular vein (PIV), the coronary sinus (CS) and the small cardiac vein (SCV). We determined the sizes of measurable CS (n = 16) and GCV (n = 12) at the end systolic and mid diastolic phases. -
Coronary Sinus Cryoablation of Ventricular Tachycardia After Failed Radiofrequency Ablation
www.symbiosisonline.org Symbiosis www.symbiosisonlinepublishing.com Case Report Journal of Clinical Trials in Cardiology Open Access Coronary Sinus Cryoablation of Ventricular Tachycardia after Failed Radiofrequency Ablation Jiménez-Fernández M*, Macías- Ruiz R, Álvarez-López M, and Tercedor- Sánchez L Virgen de las Nieves University Hospital, Granada, Spain Received: March 11, 2014; Accepted: September 10, 2014; Published: September 25, 2014 *Corresponding author: Miriam Jiménez-Fernández, Virgen de las Nieves University Hospital, Granada, Spain, E-mail: [email protected] Abstract We present a case of Great Cardiac Vein (GCV) cryoablation in order to suppress idiopathic epicardial Ventricular Tachycardia (VT) after failed Radiofrequency (RF) ablation via the epicardium and GCV. RF ablation is the technique of choice for the treatment of Ventricular Arrhythmias (VA). However, this procedure has its limitations when delivered inside the distal cardiac veins. Cryoablation is a good alternative in patients where RF cannot be used because of risk of high impedance. Keywords: Percutaneous epicardial ablation; Ventricular tachycardia; Radiofrequency; Catheter ablation; Cryoablation; Coronary sinus; High impedance; Cryoenergy; Great cardiac vein; Mapping; Electroanatomic mapping system; 12-lead surface electrocardiogram Case Report tachycardia, but the delivery of RF had to be interrupted with a maximal energy of 15 W, as the impedance rise exceeded the A 56-year-old female patient presented in emergency room referring shortness of breath and chest pain. ECG showed we decided to change to a 6 mm tip cryoablation catheter that was sustained monomorphic VT at 160 beats per minute with right ablesafety to limit reach (>300 the programmed Ω) (Figure 1C). temperature In order to of solve -80°C this suppressing problem, bundle branch block and right inferior axis morphology (Figure the VT with no further recurrences. -
Brief Communications
View metadata, citation and similar papers at core.ac.uk brought to you byCORE provided by Elsevier - Publisher Connector BRIEF COMMUNICATIONS CARDIOMYOPLASTY COMBINED WITH IMPLANTATION OF A CARDIOVERTER DEFIBRILLATOR Valeri S. Chekanov, MD, PhD, Sanjay Deshpande, MD, and Donald H. Schmidt, MD, Milwaukee, Wis. In the United States alone, approximately 2 to 3 million 58/25 mm Hg and mean 36 mm Hg), elevated pulmonary patients generally are affected by heart failure, and this capillary wedge pressure (an atrial wave of 28 mm Hg, number is likely to increase. 1 Survival of patients with ventricular wave of 42 mm Hg, and mean of 32 mm Hg), advanced ventricular dysfunction is limited not only by and reduced cardiac index (2.12 L/min/m2). Coronary progressive pump dysfunction but also by the risk of angiography showed severe three-vessel coronary artery sudden cardiac death. The 1-year mortality risk exceeds disease. The left ventricle was severely hypocontractile, 50% for patients with class IV symptoms. 2 Dynamic with an ejection fraction of 10%. cardiomyoplasty is emerging as a promising form of Latissimus dorsi cardiomyoplasty was chosen instead of surgical therapy for patients with advanced ventricular heart transplantation because the patient did not have dysfunction, but sudden cardiac death remains a major end-stage heart failure. Cardiomyoplasty was performed factor in decreased long-term survival among patients who through a medial sternotomy and a posterior wrap was have undergone cardiomyoplasty.3 Among the various performed. A Medtronic cardiostimulator (Medtronic, available therapeutic strategies for patients at high risk for Inc., Minneapolis, Minn.) was implanted with the myocar- sudden cardiac death, the implantable cardioverter defi- dial and skeletal electrodes placed in the conventional brillator (ICD) has been shown to be effective. -
Pressure-Volume Measurements By
PRESSURE-VOLUME MEASUREMENTS BY CONDUCTANCE CATHETER METHOD IN THORACIC SURGERY AND INTENSIVE CARE STUDIES CD Leycom Argonstraat 116 2718 SP Zoetermeer The Netherlands Tel: (31) 79 360 1780 Fax: (31) 79 362 1743 Email: [email protected] Website: www.cdleycom.com Version 0035.0 Ref.: CC-SURG.REV.V0035 1. CARDIOMYOPLASTY and AORTOMYOPLASTY In cardiomyoplasty dilated cardiomyopathy is treated by surgically wrapping the right latissimus muscle around the heart.The purpose of this is to stimulate the muscle, after having been conditioned for several months, in order to assist the ventricle in ejection during selected heart beats. The clinical success of this method is still debated. One of the important issues is how to evaluate the effects of the procedure in terms of improved pump function of the left ventricle. One of the most useful (or even the only) ways of assessing changed hemodynamics and contractile performance is the registration of left ventricular pressure- volume loops. Such loops may be constructed on a continuous basis during preload reduction (by transient vena cava occlusion) using the conductance catheter as has been done in several animal studies (1, 2, 3, 4). The general conclusion of these studies was that the proper stimulation protocol of the wrapped muscle effectuated an increase in contractility expressed by a leftward displacement and/or steeper slope of the end-systolic pressure-volume relation (ESPVR). A similar analysis, applied in human patients after undergoing cardiomyoplasty, has been published recently (5). Although no load reduction was performed in this multi- clinical study, it was shown convincingly that a stimulated heart beat when compared to unstimulated beats, resulted in an increased stroke volume mainly effectuated through a decrease in end-systolic volume, provided an optimal stimulation setting was utilized. -
Biointerventional Cardiovascular Therapy
European Heart Journal (2002) 23, 1753–1756 doi:10.1053/euhj.2002.3321, available online at http://www.idealibrary.com on Review Article Biointerventional cardiovascular therapy I. D. Cox, C. A. Thompson and S. N. Oesterle Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, U.S.A. Introduction However, viral vectors (such as adeno- and retroviruses) are generally considered to provide superior gene trans- Recent advances in gene and cell based therapies have fer efficiency in terms of both magnitude and duration of created exciting possibilities for therapeutic modification gene expression[4]. Non-selective delivery of adenoviral of local vascular and myocardial biology. The parallel vectors, either by intracoronary injection[5] or pressure- evolution of increasingly sophisticated catheter-based regulated retroinfusion via the coronary veins[6], can systems is currently expanding the frontiers of percu- result in diffuse distribution throughout the myocar- taneous intervention in cardiovascular disease[1,2] and dium. More selective gene transfer can be achieved by offers the possibility of delivering gene and cell based direct injection of genetic material into myocardium[7]. therapies by minimally invasive means. This conver- The latter approach achieves higher local tissue con- gence of biotechnology and advanced catheter based centration of therapeutic substrate and thereby seems systems can sensibly be referred to as bio-interventional likely to prove more efficient and less liable to produce cardiovascular therapy and rapid progress is currently undesirable effects in other vascular beds. In most cases, being made in a number of areas within this field. selective local injection of genetic substrate has been achieved through open surgical access to the myocar- dium. -
Percutaneous CT-Guided Renal Cryoablation: Technical Aspects, Safety, and Long-Term Oncological Outcomes in a Single Center
medicina Article Percutaneous CT-Guided Renal Cryoablation: Technical Aspects, Safety, and Long-Term Oncological Outcomes in a Single Center Stefano Cernic 1,* , Cristina Marrocchio 2 , Riccardo Ciabattoni 2, Ilaria Fiorese 2, Fulvio Stacul 3, Fabiola Giudici 4,5 , Michele Rizzo 6 and Maria Assunta Cova 2 1 Department of Radiology, ASUGI, Ospedale di Cattinara, 30149 Trieste, Italy 2 Department of Radiology, University of Trieste, ASUGI, Ospedale di Cattinara, 34149 Trieste, Italy; [email protected] (C.M.); [email protected] (R.C.); fi[email protected] (I.F.); [email protected] (M.A.C.) 3 Department of Radiology, ASUGI, Ospedale Maggiore, 30125 Trieste, Italy; [email protected] 4 Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35122 Padova, Italy; [email protected] 5 Unit of Biostatistic, Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy 6 Department of Urology, University, ASUGI, Ospedale di Cattinara, 30149 Trieste, Italy; [email protected] * Correspondence: [email protected]; Tel.: +39-040-399-4372; Fax: +39-040-399-4350 Abstract: Background and objectives: Cryoablation is emerging as a safe and effective therapeutic option for treating renal cell carcinoma. This study analyzed the safety and long-term oncological outcomes of cryoablation in our center. Materials and methods: Patients who underwent computed Citation: Cernic, S.; Marrocchio, C.; tomography (CT)-guided percutaneous cryoablation between February 2011 and June 2020 for one Ciabattoni, R.; Fiorese, I.; Stacul, F.; or more clinically localized renal tumors were identified. Technical success and treatment efficacy Giudici, F.; Rizzo, M.; Cova, M.A. -
Cardiac Output 98
Chapter Cardiac Output 98 INTRODUCTION DEFINITIONS AND NORMAL VALUES STROKE VOLUME MINUTE VOLUME CARDIAC INDEX EJECTION FRACTION CARDIAC RESERVE VARIATIONS IN CARDIAC OUTPUT PHYSIOLOGICAL VARIATIONS PATHOLOGICAL VARIATIONS DISTRIBUTION OF CARDIAC OUTPUT FACTORS MAINTAINING CARDIAC OUTPUT VENOUS RETURN FORCE OF CONTRACTION HEART RATE PERIPHERAL RESISTANCE MEASUREMENT OF CARDIAC OUTPUT DIRECT METHODS INDIRECT METHODS CARDIAC CATHETERIZATION DEFINITION CONDITIONS WHEN CARDIAC CATHETERIZATION IS PERFORMED PROCEDURE USES OF CARDIAC CATHETERIZATION INTRODUCTION 1. Stroke volume 2. Minute volume Cardiac output is the amount of blood pumped from 3. Cardiac index. each ventricle. Usually, it refers to left ventricular output However, in routine clinical practice, cardiac output through aorta. Cardiac output is the most important refers to minute volume. factor in cardiovascular system, because rate of blood flow through different parts of the body depends upon STROKE VOLUME cardiac output. Stroke volume is the amount of blood pumped out by each ventricle during each beat. DEFINITIONS AND NORMAL VALUES Normal value: 70 mL (60 to 80 mL) when the heart rate Usually, cardiac output is expressed in three ways: is normal (72/minute). Chapter 98 t Cardiac Output 573 MINUTE VOLUME 5. Environmental temperature: Moderate change in temperature does not affect cardiac output. Increase Minute volume is the amount of blood pumped out by in temperature above 30°C raises cardiac output. each ventricle in one minute. It is the product of stroke 6. Emotional conditions: Anxiety, apprehension and volume and heart rate: excitement increases cardiac output about 50% to Minute volume = Stroke volume × Heart rate 100% through the release of catecholamines, which Normal value: 5 L/ventricle/minute. -
Cryoablation
CryoAblation “My AF symptoms come and go, so I don’t think I need surgery.” The American Heart Association recommends treatment for atrial fibrillation whether you can feel symptoms or not. If AF is diagnosed and not treated – regardless of whether you experience symptoms or not – it may lead to a stroke, heart failure or fatigue. If your AF does not improve after the use of one 704.83.HEART | caromonthealth.org antiarrhythmic medication, CryoAblation may be an option to help treat your AF. caromonthealth.org | 704.83.HEART CryoAblation is a minimally-invasive “I don’t really understand the procedure.” “I’m scared to have surgery.” CryoAblation is a minimally invasive procedure in which an As with any medical procedure, there are benefits and risks with procedure that can be used when electrophysiologist – a heart doctor who specializes in heart rhythms – CryoAblation. CryoAblation is a minimally invasive procedure, meaning medication fails to control atrial fibrillation threads a flexible thin tube – a catheter – through the blood vessels to there is no need to open the chest or do any major incisions. your heart. In most cases, the major blood vessel in your groin is used. (AF). Ablation therapy is shown to There can be local irritation or bleeding at the site of the incision During the procedure, you will receive either general anesthesia or (typically your groin area), and there is some risk of more serious effectively treat AF and help improve conscious sedation. When the targeted area in the heart is located, complications. Patients typically return to regular activities quickly. -
Basic Appl Myol 8 (1), 1998 - Myologynews Abstracts of the International Workshop on Dynamic Cardiomyoplasty, Padova - January 17-18, 1998 (IWDC98)
Basic Appl Myol 8 (1), 1998 - MyologyNews Abstracts of the International Workshop on Dynamic Cardiomyoplasty, Padova - January 17-18, 1998 (IWDC98) Institute of Cardiovascular Surgery & Future perspectives for Cardiomyoplasty include the use C.N.R. Unit for Muscle Biology and Physiopathology of minimally invasive video-assisted techniques, the University of Padova evaluation of a vascular delay between latissimus dorsi muscle dissection and cardiac wrapping, the International Workshop on modification of the post-operative electrostimulation protocol (using an intermittent LDM pacing: "demand Dynamic Cardiomyoplasty Cardiomyoplasty"), and the use of anabolic steroids and growth factors to improve muscle function. There is a new tendency to associate Cardiomyoplasty with (IWDC98) electrophysiological therapy. These therapies include the implantation of ventricular defibrillators, cardiac January 17- 18, 1998 multiple pacing, and the induction of a permanent AV block and subsequent cardiac pacing in Cardiomyoplasty Hotel Plaza - Padova, Italy patients suffering from atrial fibrillation. The clinical use of aortomyoplasty is under Scientific Board investigation; muscle-powered artificial ventricle is Ugo Carraro, President; Alain Carpentier, Dino progressing and a new promising technique, cellular and Casarotto, Juan C. Chachques, Valeri S. Chekanov, Ray C- molecular Cardiomyoplasty, is emerging. J Chiu, Claudio Muneretto, Stanley Salmons IMPROVING CARDIOMYOPLASTY RESULTS: Topics INTRODUCTION OF AN INTEGRATED FIVE-STEP APPROACH FOR OVERCOMING WEAK POINTS Minimally invasive videoassisted Cardiomyoplasty - Vascular delay - Monitoring of cardiac function - Valeri S. Chekanov, Victor V. Nikolaychik, Michelle Conditioning and regime stimulation protocols - LD flap A. Rieder, Donald H. Schmidt monitoring - Demand Dynamic Cardiomyoplasty Milwaukee Heart Project, Wisconsin, USA. In a previous clinical study (Russia 1988-1993), 35 Local Organizers patients underwent dynamic Cardiomyoplasty (CMP) U.