What We Do The Department of Quantitative Health Sciences provides researchers at Cleveland Clinic with services in: The Department of Quantitative Health Sciences  comprises over 90 members in four sections and • Grant application development an informatics core. Each section has the ability to  assist researchers in a number of tasks. • Sample size estimation   • Clinical study design • The Section helps you The Department design your study and analyze the . • methods Our determine how many  subjects are needed, what needs to be • Secure database development and maintenance of Quantitative measured, and the most appropriate • Use of Electronic Medical Record data in research  methods for analysis. Health Sciences • The Clinical Trials Design and Analysis • Retrieval and analysis of EPIC data  OUR GOAL: YOUR RESEARCH SUCCESS Section works with investigators to design • Biostatistical analysis and conduct small and large single- and  multi-center randomized clinical trials. We • Outcomes research also perform interim and final analyses and • Prediction models and software assist in reporting results. • The Health Outcomes Research and • Cost-effectiveness analysis and Clinical Section provides decision analysis

physicians with quality-of-life assessment • Comparative Effectiveness Research (CER) tools, cost effectiveness analyses, and

• Collaboration in the writing of epidemiological research. We develop and  test state-of-the-art models for use in scientific articles outcome risk calculators for cancers, heart • Federally-regulated studies , diabetes, etc., and help physicians

• Educational and training tutorials ) determine the best choices for patient care. )

• The Statistical Genetics and H 

Bioinformatics Section works with

Our website for additional information and requests YDOX for 

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investigators to design, conduct, and collaboration is: www.clevelandclinic.org/qhs −

3  ( interpret analyses of genetic data. We can (

help you with a variety of genetic studies,  

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including gene expression, genome-wide OR  −

association, eQTL, integrated omic and − next-generation sequencing studies.  • The Research Informatics Core provides data collection tools, database development,  and maintenance for clinical research Department of Quantitative Health Sciences &KURPRVRPH Cleveland Clinic  studies including those for drug and device Desk JJN3-01

trials. We also develop and host databases 9500 Euclid Avenue.  Cleveland, OH 44195  for disease and treatment registries. [email protected] © The Cleveland Clinic Foundation 05/2008

Our Goal: Your Research Success QHS: An Excellent Resource for You! Grant Development

The Department of Quantitative Health Sciences Cleveland Clinic has its own team of biostatisticians, We provide free support to investigators to assist in has expertise in all aspects of clinical research. epidemiologists, outcomes researchers, database the design of studies and the preparation of well-written From study design to statistical analysis to developers, and programmers in the Department of grants that can increase the probability of funding. preparing funding applications, we will help you and Quantitative Health Sciences. Our pledge is to be better, Members of the Department of Quantitative Health your department achieve sound scientific results faster, and/or less expensive than any research group Sciences work on many NIH and industry-sponsored from your research project in a timely manner. that operates outside of the Cleveland Clinic. studies. Our success stories include:

Each year, we co-author hundreds of publications Here are just a few areas the department specializes in: • $1.2 million from the NIH to develop a and receive millions of dollars in external funding. web-based risk calculator system. • Design We have the knowledge and skills to partner with each Cleveland Clinic Institute. • Biostatistics • $1.3 million from AstraZeneca International

• Epidemiology for a pilot study on diabetes patients.

• Statistical Genetics • $10 million from the State of Ohio to ear • Outcomes Research om Baseline to One Y investigate new imaging tests to detect early • Quality-of-life Assessment lung cancer. Comparison of Changes fr • Database Development

40 Group • $15 million from the NIH to study hemodialysis 1 • Regulated Studies 2 dose and access. 20 The Department is available to all Cleveland Clinic

0 physicians, researchers, and support staff on a • $12 million from the NIH to study chronic pay-as-you-go or dedicated-FTE fee basis. kidney disease in African Americans.

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edialysis Systolic BP (mmHg) BP Systolic edialysis 25 Do you need help training staff for an upcoming research

Pr -40 0 -25 -50 project? We will teach your residents, fellows, medical -75 -100 -60 entricular Mass (g) -125 Left V students and support team about conducting clinical -150 -175 studies, efficient data collecting methods, and other important research skills.

“They consistently met deadlines with “They took the time to learn about the enthusiasm, had thoughtful suggestions and “Their work on transplant nomograms was nothing underlying issues related to our research, and designed the analysis for a recently funded U01 short of excellent. I could not keep up with their came up with innovative approaches to analyze to investigate the impact of respiratory viral rapid turnaround times. The quality of their work triggers of alloimmunity and autoimmunity in data and plan studies.” was excellent and professionally impeccable.” pediatric lung transplantation.”