ENSA Antibody Cat. No.: 55-188
ENSA Antibody
Flow cytometric analysis of 293 cells (right histogram) Western blot analysis in mouse brain tissue lysates compared to a negative control cell (left histogram).FITC- (35ug/lane). conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Specifications
HOST SPECIES: Rabbit
SPECIES REACTIVITY: Human, Mouse
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, HOMOLOGY: Pig, Rat, Xenopus
This ENSA antibody is generated from rabbits immunized with a KLH conjugated synthetic IMMUNOGEN: peptide between 39-66 amino acids from the Central region of human ENSA.
TESTED APPLICATIONS: Flow, WB
October 1, 2021 1 https://www.prosci-inc.com/ensa-antibody-55-188.html For WB starting dilution is: 1:1000 APPLICATIONS: For FACS starting dilution is: 1:10~50
PREDICTED MOLECULAR 13 kDa WEIGHT:
Properties
This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.
CLONALITY: Polyclonal
ISOTYPE: Rabbit Ig
CONJUGATE: Unconjugated
PHYSICAL STATE: Liquid
BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION: batch dependent
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
OFFICIAL SYMBOL: ENSA
ALTERNATE NAMES: Alpha-endosulfine, ARPP-19e, ENSA
ACCESSION NO.: O43768
GENE ID: 2029
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
ENSA belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a BACKGROUND: key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes.
REFERENCES: 1) Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
October 1, 2021 2 https://www.prosci-inc.com/ensa-antibody-55-188.html 2) Olsen, J.V., et al. Cell 127(3):635-648(2006)
3) Olsen, J.V., et al. Cell 127(3):635-648(2006)
4) Gabrielsson, B.G., et al. Mol. Cell. Biochem. 258 (1-2), 65-71 (2004) :
ANTIBODIES FOR RESEARCH USE ONLY.
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