ENSA Antibody Cat. No.: 55-188

ENSA Antibody

Flow cytometric analysis of 293 cells (right histogram) Western blot analysis in mouse brain tissue lysates compared to a negative control cell (left histogram).FITC- (35ug/lane). conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse

Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, HOMOLOGY: Pig, Rat, Xenopus

This ENSA antibody is generated from rabbits immunized with a KLH conjugated synthetic IMMUNOGEN: peptide between 39-66 amino acids from the Central region of human ENSA.

TESTED APPLICATIONS: Flow, WB

October 1, 2021 1 https://www.prosci-inc.com/ensa-antibody-55-188.html For WB starting dilution is: 1:1000 APPLICATIONS: For FACS starting dilution is: 1:10~50

PREDICTED MOLECULAR 13 kDa WEIGHT:

Properties

This antibody is purified through a A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: ENSA

ALTERNATE NAMES: Alpha-endosulfine, ARPP-19e, ENSA

ACCESSION NO.: O43768

GENE ID: 2029

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

ENSA belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the , ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a BACKGROUND: key role in the control of release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this has been proposed as a candidate gene for .

REFERENCES: 1) Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

October 1, 2021 2 https://www.prosci-inc.com/ensa-antibody-55-188.html 2) Olsen, J.V., et al. Cell 127(3):635-648(2006)

3) Olsen, J.V., et al. Cell 127(3):635-648(2006)

4) Gabrielsson, B.G., et al. Mol. Cell. Biochem. 258 (1-2), 65-71 (2004) :

ANTIBODIES FOR RESEARCH USE ONLY.

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