Supplementary Figure 1

E-cadherin 135kDa

ACTIN 38kDa

Supplementary Figure 2

4

2

0 AXL -2 ALK -4 MET Delta Z score MET ALK -6 KDR KDR AXL -8

-10 0 500 1000 1500 Ranked siRNA

Supplementary Figure 3 A02 Parental

MCF7 MCF7

ROS1 245kDa

135kDa MET

ALK 245kDa

E-cadherin 135kDa

Actinin 75kDa Supplementary Figure 4

A B

E-cadherin E-cadherin siCDC42BPA siPLK4 2 2 Null Null mutated gene: CDH1 Wild type defective wild type Wild type 0 0

2 2 * -2 *

CDC42BPA -2 0 0

PLK4 -2 MAPKAPK3 -2

Zscore -4 Zscore Median Z score Median

Median Z score Median -4 GSK3A -4 -4 -6 ROS1 ROCK2 -6 -6 -8 Null Null PSKH2 Wild type Wild type -6 RELA STK16 BT20_BREASTT47D_BREAST BT20_BREAST T47D_BREAST BT474_BREAST VP229_BREASTCAL51_BREAST JIMT1_BREAST ZR751_BREAST MCF7_BREASTBT549_BREAST BT474_BREASTMCF7_BREAST BT549_BREASTZR751_BREASTJIMT1_BREASTVP229_BREAST CAL51_BREAST CAMA1_BREASTHS578T_BREASTCAL120_BREASTSKBR3_BREASTHCC38_BREAST SUM52_BREASTHCC70_BREASTSUM44_BREASTZR7530_BREASTHCC202_BREASTDU4475_BREAST CAMA1_BREAST HCC38_BREASTHS578T_BREASTSKBR3_BREASTCAL120_BREAST ZR7530_BREASTSUM44_BREASTSUM52_BREASTHCC70_BREAST DU4475_BREAST SUM149_BREASTSUM159_BREAST MFM223_BREASTHMT3552_BREAST HCC1954_BREASTHCC1143_BREASTMCF12A_BREAST MCF10A_BREAST SUM149_BREAST HMT3552_BREASTMFM223_BREASTSUM159_BREASTMCF10A_BREAST HCC202_BREASTMCF12A_BREAST HCC1954_BREASTHCC1143_BREAST STK33 MDAMB453_BREAST MDAMB157_BREAST MDAMB436_BREAST MDAMB468_BREASTMDAMB231_BREAST MDAMB453_BREASTMDAMB157_BREASTMDAMB436_BREASTMDAMB231_BREASTMDAMB468_BREAST MDAMB134VI_BREAST MDAMB134VI_BREAST EPHB3 siMAPKAPK3 siGSK3A PRKCA DUSP21 2 Null Null EIF2AK1 2 Wild type Wild type AAK1 0 SRPK3 HIPK2 0

TEC 4 -2 * PIK3R2 * -2 2 TAB1 0 0 -4 SIK1 Median Z score Median Zscore Median Z score Median

-2 Zscore ACVR2A -4 -5 TAOK2 -4 -6 PRKAG2 -6 Null Null YES1 Wild type -6 Wild type CDKN2B -8

MLTK T47D_BREAST BT549_BREAST BT474_BREASTZR751_BREASTBT20_BREAST VP229_BREAST JIMT1_BREAST MCF7_BREAST SKBR3_BREASTHCC38_BREASTHS578T_BREASTZR7530_BREASTCAMA1_BREASTCAL120_BREAST SUM44_BREASTCAL51_BREAST HCC70_BREAST SUM52_BREASTDU4475_BREAST SUM159_BREAST HCC202_BREASTSUM149_BREAST MFM223_BREAST MCF12A_BREAST MCF10A_BREAST BT20_BREAST T47D_BREAST HCC1954_BREASTHMT3552_BREASTHCC1143_BREAST ZR751_BREASTJIMT1_BREASTVP229_BREAST MCF7_BREAST BT549_BREASTBT474_BREAST SKBR3_BREAST CAL51_BREASTHS578T_BREAST HCC38_BREAST ZR7530_BREASTSUM52_BREASTHCC70_BREASTDU4475_BREASTSUM44_BREAST CAMK1G MDAMB157_BREAST MDAMB436_BREASTMDAMB231_BREAST MDAMB468_BREASTMDAMB453_BREAST MFM223_BREASTMCF10A_BREASTSUM159_BREAST HCC202_BREASTMCF12A_BREASTCAL120_BREAST SUM149_BREASTCAMA1_BREAST MDAMB134VI_BREAST HCC1143_BREAST HCC1954_BREASTHMT3552_BREAST MDAMB157_BREASTMDAMB231_BREAST MDAMB436_BREAST MDAMB453_BREAST MDAMB468_BREAST DYRK1A MDAMB134VI_BREAST CHEK2 siROS1 IPMK 1 Null ACVR1B Wild type DDR1 0 GCK MET

PRKCZ -1 2 * CAMK4

PRKCD 0 ADCK4 -2 Zscore MAP4K5 Z score Median -2 PI4KB -3 STRADA -4

PHKG2 Null

Wild type SHPK -4

BT20_BREAST T47D_BREAST BT549_BREAST VP229_BREAST ZR751_BREAST SUM52_BREASTJIMT1_BREASTMCF7_BREASTHCC70_BREASTCAL51_BREAST BT474_BREAST HS578T_BREAST SKBR3_BREASTSUM44_BREASTCAL120_BREAST SUM149_BREASTHCC38_BREASTDU4475_BREAST HCC202_BREASTZR7530_BREASTCAMA1_BREAST SUM159_BREASTHMT3552_BREAST MCF12A_BREAST MCF10A_BREASTHCC1954_BREASTHCC1143_BREASTMFM223_BREAST MDAMB468_BREASTMDAMB231_BREAST MDAMB436_BREAST MDAMB157_BREAST MDAMB453_BREAST MDAMB134VI_BREAST BT20_BREAST BT20_BREAST T47D_BREAST MCF7_BREAST JIMT1_BREAST BT549_BREAST BT474_BREAST ZR751_BREAST VP229_BREAST CAL51_BREAST HCC38_BREAST HCC70_BREAST SKBR3_BREAST SUM52_BREAST SUM44_BREAST CAMA1_BREAST ZR7530_BREAST ZR7530_BREAST CAL120_BREAST DU4475_BREAST HS578T_BREAST HCC202_BREAST SUM149_BREAST SUM159_BREAST MCF12A_BREAST MCF10A_BREAST MFM223_BREAST HMT3552_BREAST HCC1143_BREAST HCC1954_BREAST MDAMB468_BREAST MDAMB157_BREAST MDAMB231_BREAST MDAMB436_BREAST MDAMB453_BREAST MDAMB134VI_BREAST N=12 N=22

Supplementary Figure 5

MET ALK ROS1 3 2 ** 1

2 0 0

1 -1 -2 NPI NPI NPI Z score Z score Z score 0 -2

-4 -1 -3

-2 -6 -4

E-cadherinNull E-cadherin E-cadherinNull E-cadherin E-cadherinNull E-cadherin defective Wildwild type type defective Wildwild type type defective Wild wildtype type Supplementary Figure 6 A !""#$%&'($ !""#$$"% 4333 )/

,233

). ,333

233 56789&&(%- 0123%4456* expression expression / Normalized mRNA Normalized mRNA Normalized mRNA Normalized mRNA 3

1233 . E-cadherin E-cadherin E-cadherin E-cadherin defective wild type )*+,#/0 defective wild type )*+,#-."" &'()#,- &'()#*+""

B mutated gene: CDH1 C 3456'%7'*87987:;'<9ROS1 siRNA E-cadherin defective E-cadherin wild type .

!! TGFBR2 KSR1 STK39 PI4KA / PTK7 GALK2 ERN1 DGCR14 DGKI PDGFRA ADRBK1 PDK4 0 TEX14 NEK8 CSNK2B HIPK2

DGKQ !12' ACVR2B

RELA Z score TESK1 STK33 ,/ RPS6KA5 DYRK1B MARK3 TSSK3 PRKDC MAP2K1 PAPSS2 SYK ,. DMPK PIK3R5 PFKFB4 ABL2 PRKCH ROS1 INSR ROS1 SGK494 RPS6KL1 ,- RNASEL SPHK1 CDKL2 E-cadherin E-cadherin IKBKAP !"## CDK5 PANK2 defective wild type CKS1B $%#&'()*+ ITPKC EIF2AK3 PAK6 MAST1 MAK BMX GK2 MLTK CAMKK1 FXN STK10 DLG2 RYK CHKB TLK2 XRCC6BP1 ITPKB COMMD3 GRK1 CAMK2G PIK3CD PI4K2A CDKL5 RFK PAK3 BLK XYLB MAP4K2 SCYL3 PRKCD PRKCE FLT1 PIK3CA PRKACB NRBP1 MAP3K2 NY_BONE H23_LUNG BEN_LUNG HOS_BONE A427_LUNG A549_LUNG H460_LUNG H292_LUNG H358_LUNG H727_LUNG ES2_OVARY G292_BONE MG63_BONE NOS1_BONE U2OS_BONE HUO9_BONE H1299_LUNG H1793_LUNG H2228_LUNG H1650_LUNG H1838_LUNG H1975_LUNG H2342_LUNG OV56_OVARY OV90_OVARY CAL72_BONE SJSA1_BONE RMGI_OVARY HOP62_LUNG SAOS2_BONE OVISE_OVARY SKOV3_OVARY CAOV3_OVARY OAW42_OVARY HUO3N1_BONE COV362_OVARY COV504_OVARY TOV21G_OVARY SIHA_CERVICAL C33A_CERVICAL C33A_CERVICAL OVTOKO_OVARY OVMANA_OVARY TOV112D_OVARY PL45_PANCREAS CASKI_CERVICAL HPAC_PANCREAS SNU16_STOMACH KATOIII_STOMACH ASPC1_PANCREAS BXPC3_PANCREAS TE1_OESOPHAGUS TE5_OESOPHAGUS TE6_OESOPHAGUS TE8_OESOPHAGUS TE9_OESOPHAGUS TE10_OESOPHAGUS TE11_OESOPHAGUS TE14_OESOPHAGUS OE19_OESOPHAGUS OE33_OESOPHAGUS MIAPACA2_PANCREAS MIAPACA2_PANCREAS KYSE70_OESOPHAGUS AN3CA_ENDOMETRIUM HEC1A_ENDOMETRIUM MFE296_ENDOMETRIUM JMSU1_URINARY_TRACT DLD1_LARGE_INTESTINE

KNS42_CENTRAL_NERVOUS_SYSTEM N=35 N=34 Supplementary Figure 7

ROS1_2 ROS1_3 A ROS1_1 B C 1.5 4 2.0 ** **** **** **p < 0.05 1.5 3 ***p < 0.001

1.0 1.0 2 NPI NPI NPI NPI NPI NPI 0.5

0.5 1 0.0

0 -0.5 0.0 E-cadherinNull E-cadherin E-cadherinNull E-cadherin E-cadherinNull E-cadherin defective wild type defective wild type Wild type defective wild type Wild type Wild type ROS1_4 ROS1_5

D 3 E **** ****

2 2 NPI NPI 1 NPI

1 NPI

0 0

E-cadherinNull E-cadherin E-cadherin E-cadherin defective wild type Null Wild type defective wild type Wild type

Supplementary Figure 8

SLC34A2-ROS1 translocation-positive E-cadherin defective E-cadherin wild type SUM44 EpithelialNo EMT 1.5 SKBR3 BT549 MesenchymalEMT CAL120 SUM149 MesenchymalEMT 1.0 HCC78

0.5 Surviving fraction Surviving

0.0 -8.2 -7.7 -7.2 -6.7 -6.2 -5.7 -5.2 Foretinib(M) Supplementary Figure 9 A Mutation Promoter methylation Deletion!

ZR75.1 CAL120 T47D MDAMB453CAMA-1 BT549 JIMT1 VP229 SUM149MDAMB468 BT474 MDAMB134VI SKBR3 SUM44 SUM159 MDAMB157 MCF7 CAL51 HS578T MCF12A MFM223 MDAMB231MDAMB436 MET 135kDa

245kDa ALK

135kDa E-cadherin

pAKT 63kDa

63kDa AKT

38kDa pERK

ERK 38kDa

38kDa ACTIN

E-cadherin defective E-cadherin wild type B 1.5 C 1.0 D 2.0

0.8 1.5 1.0 0.6

1.0 0.4 0.5

0.2 0.5 Normalized ALK expression Normalized MET expression 0.0 Normalized pAKT expression 0.0 0.0

T47D T47D BT549 MCF7BT474 JIMT1VP229 BT549 BT474 JIMT1 MCF7 VP229 SUM44 SKBR3 CAL51 ZR75.1 SUM44 SKBR3 ZR75.1 CAL51 MCF7 JIMT1T47D HS578T SUM159 CAL120MFM223MCF12A SUM149 HS578TSUM159 CAL120 MCF12AMFM223 SUM149 SUM44 SKBR3 BT549 BT474ZR75.1 VP229 CAL51 SUM159 CAL120 HS578T MFM223MCF12A SUM149 MDAMB436MDAMB453MDAMB231MDAMB157 MDAMB468 MDAMB157 MDAMB436MDAMB453MDAMB231MDAMB468 MDAMB134VI MDAMB134VI MDAMB157MDAMB231MDAMB436MDAMB453 MDAMB468 E F G MDAMB134VI 1.5 0.8 2.0

0.6 1.5 1.0

0.4 1.0

0.5 0.2 0.5 Normalized AKT expression Normalized ERK expression Normalized pERK expression 0.0 0.0 0.0

JIMT1 MCF7T47D JIMT1 MCF7 T47D JIMT1 MCF7 T47D BT549 SUM44 SKBR3 BT474 CAL51VP229 ZR75.1 SUM44 SKBR3BT549 BT474 CAL51 VP229ZR75.1 SKBR3 BT549 SUM44 BT474 VP229 ZR75.1CAL51 HS578TSUM159 CAL120 SUM149 MFM223 MCF12A HS578TSUM159 CAL120 MCF12AMFM223 SUM149 SUM159CAL120HS578T MFM223 MCF12ASUM149 MDAMB436 MDAMB231MDAMB157MDAMB453MDAMB468 MDAMB436 MDAMB231MDAMB157MDAMB453MDAMB468 MDAMB436 MDAMB231MDAMB157MDAMB453 MDAMB468 MDAMB134VI MDAMB134VI MDAMB134VI Supplementary Figure 10 A Mutation Promoter methylation Deletion

JIMT1 VP229 SUM149 ZR75.1 MDAMB436 T47D SUM44 SUM159 MDAMB157 BT474 MCF7 CAL51 HS578T MCF12A CAL120 MDAMB453CAMA-1 BT549 MDAMB468MDAMB134 SKBR3 MFM223 MDAMB231 ROS1 245kDa pROS1 245kDa

E-cadherin 105kDa

Actinin 105kDa

E-cadherin defective B C E-cadherin wild type 0.8 0.8

0.6 0.6

0.4 0.4

0.2 0.2 Normalized ROS1 expression Normalized pROS1 expression 0.0 0.0

MCF7 T47D JIMT1 T47DJIMT1MCF7 SUM44SKBR3 BT549 BT474ZR75.1 VP229 CAL51 SUM44 BT549 SKBR3 BT474 VP229 CAL51 ZR75.1 CAL120 SUM159HS578T MCF12A SUM149MFM223 CAL120HS578TSUM159 MCF12ASUM149 MFM223 MDAMB453MDAMB157MDAMB231 MDAMB436 MDAMB468 MDAMB453MDAMB231 MDAMB157MDAMB436MDAMB468 MDAMB134VI MDAMB134VI Supplementary Figure 11

Foretinib Crizotinib Vehicle 2.0 2.0 A B Foretinib 25 mg/kg * 4 ** **** ANOVA analysis 1.5 1.5 p<0.0001

3

1.0 1.0 log AUC log log AUC log 2 !"#!$%&'() !"#!$%&'() 0.5 0.5

Relative tumour volume tumour Relative 1 0.0 0.0 18 20 22 24 26 28 30 32 34 36 Days

Crizotinib E-cadherin defectiveE-cadherin wild type E-cadherin defectiveE-cadherin wild type Vehicle 25 mg/kg

C Vehicle D Crizotinib 25 mg/kg 4 ANOVA analysis ** H&E p<0.001

3 100µm 100µm

2 Ki67

Relative tumour volume tumour Relative 1

18 20 22 24 26 28 30 32 34 36 100µm 100µm Days Cleaved Caspase 3 100µm 100µm Supplementary Figure 12

A Mutated Promoter methylated

SNU1 SNU5 SNU484 SNU683 N87 AGS

E-cadherin

EZRIN

Actin

Foretinib 2 4 B ** 0 2

0

-2 50 50 50 uM -2 log SF log

-4 log SF Log SF -4

-6 Null Wild type -6

-8 E-cadherin E-cadherin AGS T47D MCF7 SKBR3SUM44SNU 5 BT549 SNU 1 SNU16 SNU 638CAL120 SNU 484 MFM223 NCI N87SUM149 MCF12A MCF10A defective CDH1wild wt type MDAMB157MDAMB231 CDH1 null

Crizotinib 4 4 * 2 2

0 0 50 50 50 uM -2 -2 log SF log log SF Log SF -4 -4

-6 -6 Null Wild type -8 -8

AGS E-cadherin E-cadherin T47D MCF7 SKBR3SUM44SNU 5 BT549 SNU 1 SNU16 SNU 638SNU 484CAL120 MFM223 NCI N87SUM149MCF12AMCF10A defective CDH1wild wt type MDAMB231 MDAMB157 CDH1 null

C CCLE mRNA expression Crizotinib

* **** 6

10

4 50 (µM) 50 uM SF SF

expression 5 2 mRNA expression mRNA Normalized mRNA Normalized mRNA

0 0 E-cadherin E-cadherin E-cadherin E-cadherin

defective wildCDH1 wttype defective CDH1wild wt type CDH1 null CDH1 null Supplementary Figure 13

MCF10ACDH1+/+ MCF10ACDH-/-

8hrs 24hrs

Untreated Foretinib 8hrsForetinib 24hrs Untreated Foretinib 8hrsForetinib 24hrs

High exposure 135kDa PARP1

Cleaved PARP1 63kDa

ACTIN 38kDa Supplementary Figure 14

A Student’s t-test Student’s t-test B **** mitosis+p < 0.0001 foretinib **** pmitosis+ < 0.0001 crizotinib 160 **** 140 **** **** **** 140 120 120

100 100

80 80

Time (min) 60 Time (min) 60 Time in mitosis (min) Time Time in mitosis (min) Time 40 40

20 20

0 0 Vehicle Foretinib Vehicle Foretinib Vehicle Crizotinib Vehicle Crizotinib

MCF7A02 MCF7Parental MCF7A02 MCF7Parental Supplementary Figure 15

A MCF7 A02 vehicle

B MCF7 A02 foretinib

C MCF7 A02 foretinib

D MCF7 A02 crizotinib

E MCF7 A02 crizotinib Supplementary Figure 16

A p120 | MKLP1 | DNA Vehicle Crizotinib Foretinib

Parental MCF7

10um 10um 10um

Vehicle Crizotinib Foretinib A02 MCF7

10um 10um 10um

B CDH1+/+ CDH1-/- MCF10A MCF10A

Foretinib - + - +

p-p120 (Tyr228) Low expression 100kDa

p-p120 (Tyr228) high expression 100kDa

100kDa p-p120 (Ser320)

Total p120

100kDa

E-cadherin

100kDa

!H2AX

17kDa

ACTIN 48kDa Supplementary Figure 17

A B

1.5 MCF10A CDH1 -/- MCF10A CDH1 +/+

CDC42BPA *** *** *** 1.0

siCONT siRNA_1 siRNA_2 siRNA_3 siRNA_4 siRNA_5 NPI CDC42BPA *** 170kDa 0.5

ACTIN 48kDa

0.0

1 2 3 4

siRNA

C CDC42BPA_1 CDC42BPA_2 CDC42BPA_3 2.0 2.0 **** ** **** 4

1.5 1.5

3 1.0 1.0 NPI NPI 2 NPI 0.5 0.5

1 0.0 0.0

0 -0.5

D MCF7Parental CDC42BPA_4 CDC42BPA_Pool MCF7 A02 2.0 2.0

**** **** 1.0 **** 1.5 1.5

1.0

1.0 NPI NPI 0.5 0.5 Surviving Fraction

0.5 0.0

0.0 0.0 -0.5 1µM Chelerythrine Supplementary Figure 18

A B MCF7A02 E-cadherin defective E-cadherinNull defective 4.5 8 Vehicle Foretinib 25 mg/kg *** 4.0 *** ANOVA analysis p = 0.0002 6 3.5

3.0 4 2.5 Day 41

2.0

Relative tumour volume 2

Relative tumour volume 1.5

1.0 18 20 22 24 26 28 30 32 34 36 38 40 42 0 Days Vehicle C D Foretinib 25 mg/kg

MCF7Parental E-cadherin wild type E-cadherinWT wild type 3.0 5 Vehicle ns Foretinib 25 mg/kg ns ANOVA analysis 4 2.5 p = 0.5829

3 2.0 Day 41 2

1.5 Relative tumour volume

Relative tumour volume 1

1.0 0 18 20 22 24 26 28 30 32 34 36 38 40 42

Days Vehicle E Foretinib 25 mg/kg A B A B MCF7A02 MCF7Parental MCF7A02 MCF7Parental Post Post Post Post Pre Pre foretinib Pre foretinib Pre foretinib foretinibtreatment treatment treatment treatment treatment treatment treatment treatment

C C D D E-cadherin wildE-cadherin type wild type E-cadherin defectiveE-cadherin defective Supplementary Figure 19

A B Vehicle 25mg/kg Foretinib Vehicle 25mg/kg Foretinib H&E H&E

100µm 100µm 100µm 100µm ROS1 pROS1

100µm 100µm 100µm 100µm

C Vehicle 25mg/kg Foretinib H&E

100µm 100µm MET MET

100µm 100µm Supplementary Figure 20

Uncropped western blots Fig. 1A

E-cadherin 105kDa

38kDa

ACTIN

Uncropped western blots Fig. 1F

105kDa E-cadherin ROS1 245kDa

135kDa MET

48kDa ACTIN ALK 245kDa Supplementary Figure 20

Uncropped western blots Uncropped western blots Fig. 1H Fig. 2A

ROS1 245kDa ROS1

245kDa

FLAG 135kDa 38kDa ACTIN

ACTIN 38kDa

Uncropped western blots Fig. 2E

A

FLAG

105kDa

38kDa ACTIN Supplementary Figure 20

Uncropped western blots Fig. 3A

105kDa 105kDa E-cadherin E-cadherin

38kDa ACTIN 38kDa ACTIN

105kDa 105kDa

E-cadherin E-cadherin

38kDa 38kDa ACTIN ACTIN Supplementary Figure 20 Uncropped western blots Fig. 3A

E-cadherin

E-cadherin

105kDa

105kDa

38kDa ACTIN

38kDa ACTIN

105kDa E-cadherin

38kDa ACTIN Supplementary Figure 20 Uncropped western blots Fig. 5G

24kDa p21

38kDa ACTIN

105kDa E-cadherin

Uncropped western blots Fig. 6B

105kDa E-cadherin

p-p120 105kDa (Tyr228)

p120 105kDa ACTIN 48kDa Supplementary Figure 20 Uncropped western blots Fig. 6C

245kDa FLAG FLAG 245kDa 135kDa p120 135kDa p120

245kDa FLAG

135kDa p120

48kDa ACTIN

Uncropped western blots Fig. 6D

p120 135kDa -ACTININ 105kDa ! Supplementary Figure 20 Uncropped western blots Supplementary Fig. S1

E-cadherin 105kDa

38kDa ACTIN

Uncropped western blots Supplementary Fig. S3

ROS1 245kDa

135kDa MET 135kDa E-cadherin

!-ACTININ 105kDa 245kDa ALK Supplementary Figure 20 Uncropped western blots Supplementary Fig. S9A

ALK 245kDa

135kDa MET

135kDa E-cadherin

48kDa ACTIN

Uncropped western blots Supplementary Fig. S9A

63kDa AKT

ERK 35kDa

pAKT 63kDa

35kDa

63kDa

pERK 35kDa Supplementary Figure 20

Uncropped western blots Supplementary Fig. S10A

ROS1 245kDa

245kDa pROS1

135kDa E-cadherin

105kDa ACTIN

Uncropped western blots Uncropped western blots Supplementary Fig. S12A Supplementary Fig. S13

105kDa PARP1

E-cadherin

Ezrin

38kDa ACTIN ACTIN 38kDa Supplementary Figure 20 Uncropped western blots Supplementary Fig. S16B

p-p120 (Ser320) 100kDa Low exposure p-p120 (Tyr228) 100kDa

High exposure 100kDa 100kDa p-p120 (Tyr228) p120

38kDa

ACTIN

100kDa E-cadherin

H2AX 17kDa !

Uncropped western blots Supplementary Fig. S17A

100kDa MRCK!

38kDa ACTIN