Colorectal Polypectomy and Endoscopic Mucosal Resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline

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Colorectal Polypectomy and Endoscopic Mucosal Resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline Guideline Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline Authors 19 Department of Gastroenterology, Maria Sklodowska-Curie Monika Ferlitsch1,2,AlanMoss3,4,CesareHassan5,Pradeep Memorial Cancer Bhandari6, Jean-Marc Dumonceau7,GregoriosPaspatis8,Rodrigo Center and Medical Centre for Postgraduate Education, Jover9,CordLangner10,MaximeBronzwaer11, Kumanan Nalankilli3,4, Warsaw, Poland Paul Fockens11,RawiHazzan12,IanM.Gralnek12,Michael 20 Humanitas Research Hospital, Humanitas University, Rozzano, Gschwantler2, Elisabeth Waldmann1,2, Philip Jeschek1,2, Daniela Milan, Italy Penz1, 2,DenisHeresbach13, Leon Moons14, Arnaud Lemmers15, 21 School of Medicine, Pharmacy and Health, Durham University, Konstantina Paraskeva16, Juergen Pohl17, Thierry Ponchon18, Durham, UK Jaroslaw Regula19, Alessandro Repici20, Matthew D. Rutter21, 22 Department of Gastroenterology and Hepatology, Westmead Nicholas G. Burgess22,23, Michael J. Bourke22,23 Hospital, Sydney, Australia 23 University of Sydney, Sydney, Australia Institutions 1 Department of Internal Medicine III, Division of Bibliography Gastroenterology and Hepatology, Medical University of Vienna, DOI http://dx.doi.org/10.1055/s-0043-102569 Austria Published online: 2017 | Endoscopy 2 Quality Assurance Working Group of the Austrian Society of © Georg Thieme Verlag KG Stuttgart · New York Gastroenterology and Hepatology ISSN 0013-726X 3 Department of Endoscopic Services, Western Health, Melbourne, Australia Corresponding author 4 Department of Medicine, Melbourne Medical School Western Monika Ferlitsch, MD, Division of Gastroenterology and Hepatology, Precinct, The University of Melbourne, St. Albans, Victoria, Department of Internal Medicine III, Medical University of Vienna, Australia Waehringer Guertel 18–20, A-1090 Vienna, Austria 5 Digestive Endoscopy Unit, Nuovo Regina Margherita Hospital, Fax: +43-40400-47350 Rome, Italy [email protected] 6 Solent Centre for Digestive Diseases, Queen Alexandra Hospital, Portsmouth, UK Appendix e1, e2 7 Gedyt Endoscopy Center, Buenos Aires, Argentina Online content viewable at: https://www.thieme-connect.com/ 8 Department of Gastroenterology, Benizelion General Hospital, DOI/DOI?10.1055/s-0043-102569 Heraklion, Crete, Greece 9 Unidad de Gastroenterología, Servicio de Medicina Digestiva, Instituto de Investigación Sanitaria ISABIAL, Hospital General MAIN RECOMMENDATIONS Universitario de Alicante, Alicante, Spain 1 ESGE recommends cold snare polypectomy (CSP) as the preferred 10 Department of Pathology, Medical University of Graz, Graz, technique for removal of diminutive polyps (size≤ 5mm).Thistech- Austria nique has high rates of complete resection, adequate tissue sam- 11 Department of Gastroenterology, Academic Medical Center, pling for histology, and low complication rates. (High quality evi- University of Amsterdam, Amsterdam, The Netherlands dence, strong recommendation.) This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited. ’ 12 Institute of Gastroenterology and Hepatology, Ha Emek 2 ESGE suggests CSP for sessile polyps 6– 9mminsizebecauseof Medical Center, Afula, Israel and Rappaport Family Faculty of its superior safety profile, although evidence comparing efficacy Medicine Technion-Israel Institute of Technology, Haifa, Israel with hot snare polypectomy (HSP) is lacking. (Moderate quality evi- 13 Department of Digestive Endoscopy, University Hospital, CHU dence, weak recommendation.) Fort de France, France 3 ESGE suggests HSP (with or without submucosal injection) for re- 14 Department of Gastroenterology and Hepatology, University moval of sessile polyps 10– 19mm in size. In most cases deep ther- Medical Center Utrecht, Utrecht, Netherlands mal injury is a potential risk and thus submucosal injection prior to 15 Department of Gastroenterology, Hepatopancreatology and HSP should be considered. (Low quality evidence, strong recom- Digestive Oncology, Erasme Hospital, Université Libre de mendation.) Bruxelles (ULB), Brussels, Belgium 4 ESGE recommends HSP for pedunculated polyps. To prevent 16 Konstantopoulio General Hospital, Athens, Greece bleeding in pedunculated colorectal polyps with head≥ 20mm or a 17 Department of Gastroenterology, Asklepios Klinik Altona, stalk≥ 10mm in diameter, ESGE recommends pretreatment of the Hamburg, Germany stalk with injection of dilute adrenaline and/or mechanical hemo- 18 Department of Endoscopy and Gastroenterology, Edouard stasis. (Moderate quality evidence, strong recommendation.) Herriot Hospital, Lyon, France Ferlitsch Monika et al. Colorectal polypectomy and … Endoscopy 5 ESGE recommends that the goals of endoscopic mucosal resec- and size, morphology, site, and access (SMSA) level 4. (Moderate tion (EMR) are to achieve a completely snare-resected lesion in the quality evidence; strong recommendation.) safest minimum number of pieces, with adequate margins and 7 For intraprocedural bleeding, ESGE recommends endoscopic co- without need for adjunctive ablative techniques. (Low quality evi- agulation (snare-tip soft coagulation or coagulating forceps) or me- dence; strong recommendation.) chanical therapy, with or without the combined use of dilute adre- 6 ESGE recommends careful lesion assessment prior to EMR to naline injection. (Low quality evidence, strong recommendation.) identify features suggestive of poor outcome. Features associated with incomplete resection or recurrence include lesion size An algorithm of polypectomy recommendations according to shape > 40 mm, ileocecal valve location, prior failed attempts at resection, andsizeofpolypsisgiven(▶ Fig.1). This Guideline is an official statement of the European So- ciety of Gastrointestinal Endoscopy (ESGE). The Grading of ABBREVIATIONS Recommendations Assessment, Development, and Evaluati- ASGE American Society for Gastrointestinal Endos- on (GRADE) system was adopted to define the strength of copy recommendations and the quality of evidence. CBF cold biopsy forceps CI confidence interval CRC colorectal cancer Introduction CSP cold snare polypectomy The endoscopic removal of colorectal polyps reduces the inci- EMR endoscopic mucosal resection dence and mortality of colorectal cancer (CRC) and is consid- ESD endoscopic submucosal dissection ered an essential skill for all endoscopists who perform colonos- ESGE European Society of Gastrointestinal Endoscopy copy [1 – 3]. Various polypectomy techniques and devices are FICE flexible spectral imaging color enhancement available, their use often varying based on local preferences (also Fuji Intelligent Chromo Endoscopy) and availability [4– 6]. This evidence-based Guideline was com- GRADE Grading of Recommendations Assessment, missioned by the European Society of Gastrointestinal Endos- Development and Evaluation copy (ESGE). It addresses all major issues concerning the prac- HBF hot biopsy forceps tical use of polypectomy and endoscopic mucosal resection HD-WLE high definition white light endoscopy (EMR), to inform and underpin this fundamental technique in HSP hot snare polypectomy colonoscopy and in CRC prevention. IPB intraprocedural bleeding This Guideline does not address management of anticoagu- I-SCAN i-SCAN digital contrast (Pentax; image proces- lants and other medications in the periprocedural setting, nor sing providing digital image-enhanced endos- post-polypectomy surveillance or quality measurements, as copy [IEE]) these are addressed in separate Guidelines [7– 9]. LSL laterally spreading lesion LST laterally spreading tumor MP muscularis propria Methods NBI narrow-band imaging The European Society of Gastrointestinal Endoscopy (ESGE) NICE NBI International Colorectal Endoscopic commissioned this Guideline and appointed a Guideline leader Classification (M.F.) who invited the listed authors to participate in the pro- NPV negative predictive value ject development. The key questions were prepared by the co- PEC prophylactic endoscopic coagulation ordinating team (M.F, A.M., M.J.B., C.H.) and then approved PPB post polypectomy bleeding by the other members. The coordinating team formed task PPV positive predictive value This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited. force subgroups, each with its own leader, and divided the RCT randomized controlled trial key topics (polyp classification, polypectomy for polyps sized RR relative risk <20mm, EMR for polyps ≥ 20mm, technical considerations, SMI submucosal invasion adverse events, histopathology) among these task forces (see SMSA size, morphology, site, and access Appendix 1, available online in Supplementary material). STSC snare-tip soft coagulation Each task force performed a systematic literature search to TEMS transanal endoscopic microsurgery prepare evidence-based and well-balanced statements on their WHO World Health Organization assigned key questions. Searches were performed in Medline. WLE white light endoscopy Articles were first selected by title; their relevance was then confirmed by review of the corresponding manuscripts, and ar- ticles with content that was considered irrelevant were exclud- comes, articles were individually assessed by the level of evi- ed. Evidence tables were generated for each key question, sum- dence and strength of recommendation according to the Grad- marizing the evidence of the available studies (see Appendix 2, ing of Recommendations Assessment, Development, and Eval- available online in Supplementary
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