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Acta Derm Venereol 2011; 91: 611–639 Organizer: IFSI President: Professor Laurent Misery, University of Brest, France Sonja Ständer, University of Münster, Germany Organization Committee: IFSI Board Members: Claire Abasq Jeff D. Bernhard, University of Massachusetts Medical Nicholas Boulais School, Worcester, USA Nicolas Lebonvallet Earl Carstens, University of California, Davis, USA Christelle Le Gall-Ianotto Toshiya Ebata, National Defense Medical College, Japan Laurent Misery Herrmann Handwerker, University of Erlangen-Nürnberg, Anne-Marie Roguedas-Contios Erlangen, Germany Akihiko Ikoma, Kyoto University, Kyoto, Japan Contact Address: Thomas Mettang, Deutsche Klinik für Diagnostik, Wies- Itch 2011/MCI, 24 Rue Chauchat, 75009 Paris baden, Germany Tel : +33 1 53 85 82 61; Fax : +33 1 53 85 82 83 Kenji Takamori, Juntendo University, Urayasu, Japan Website: http://www.itchbrest.com Jacek Szepietowski, Wroclaw Medical University, Poland E-mail: [email protected] Gil Yosipovitch, Wake Forest University, Winston-Salem, USA CONTENTS OF THIS ABSTRACT BOOK Program 612 List of Posters 614 Abstracts Special Interest Group 615 Invited Lectures 616 Free Communications 622 Posters Presentations 627 Index 639 © 2011 Acta Dermato-Venereologica. ISSN 0001-5555 Acta Derm Venereol 91 doi: 10.2340/00015555-1187 612 6th International Workshop for the Study of Itch – September 4–6, 2011, Brest, France SUNDAY, SEPTEMBER 4, 2011 Gender specific differences in itch processing – a functional MRI study. Astrid Stumpf, Markus 15:00 Registration Burgmer, Gudrun Schneider, Gereon Heuft, Martin 17:00–19:00 IFSI Board of Directors Schmelz, Ngoc Quan Phan, Sonja Ständer, Bettina Pfleiderer 20:00 Welcome Reception, on a boat (with a grant of Artemin expression in pruritic skin diseases: Maruho) Histopathological analysis. Megumi Nishioka, Hiroyuki Murota, Ichiro Katayama Evaluation of the relationship between stress, MONDAY, SEPTEMBER 5, 2011 pruritus and quality of life in lichen planus. Adam 07:30–09:00 SIG Meeting: Itch Questionnaires Reich, Kalina Welz-Kubiak Chairs: Elke Weisshaar and Gil Yosipovitch 15:30–16:00 Coffee Break and Poster Session 09:00–09:30 Opening of the Congress Chairs: Sonja Ständer and Laurent Misery 16:00–17:30 Clinical and Pathophysiological Aspects (3) (IP11–12) 09:30-11:00 Psychological and Epidemiological Aspects Chairs: Sonja Ständer and Gil Yosipovitch (IP01–04) 16:00–16:15 Role of proteases, proteinase-activated receptors Chairs: Jacek Szepietowski and Kenji Takamori and peptidases in skin inflammation and skin barrier 09:30–09:45 Itch in adolescents, Jon Anders Halvorsen function, Martin Steinhoff 09:45–10:00 Mental induction of itch, Jörg Kupfer 16:15–16:45 Free communications (FC07–08) 10:00–10:15 Stress and itch in chronic skin diseases, Andrea Evers Differential processing of cowhage and histamine 10:15-10:30 Neural correlates of delusional infestationn, itch in health and disease. Insights into brain Markus Kölle processing of chronic pruritus revealed by arterial 10:30-11:00 Free communications (FC01–02) spin labeling fMRI, Alexandru D.P. Papoiu, Influence of negative and positive emotions on Robert Coghill, Robert Kraft, Gil Yosipovitch the sensitivity to itch and pain, Antoinette van Expression profiles of thermo-Trp channels in Laarhoven, Annika Walker, Oliver Wilder-Smith, chronic pruritus, Heike Benecke, Julia Wördehoff, Sabine Kroeze, Piet van Riel, Peter van de Tobias Lotts, Martin Marziniak, Thomas A. Luger, Kerkhof, Floris Kraaimaat, Andrea Evers Hanns Hatt, Sonja Ständer Impact of the 2011 Great East Japan Earthquake on 16:45–17:00 Pruritus from the sea, Laurent Misery patients with skin diseases – an experience from participating in a dermatological support group that 17:00–17:15 Presentation of the Acta Dermo-Venereologica, went to the disaster stricken areas, Toshiya Ebata Anders Vahlquist 11:00-11:30 Coffee Break and Poster Session 17:15–18:00 General Assembly of IFSI 11:30-12:30 Clinical and Pathophysiological Aspects (1) 18:00–18:30 Board of Directors of IFSI (IP05–08) 19:00 Gala Evening, Awards and Visit of Oceanopolis Chairs: Alan Fleischer and Toshiya Ebata 11:30–11:45 Drug-induced pruritus, Jacek Szepietowski 11:45–12:00 Aquagenic pruritus in polycythemia vera, Christelle TUESDAY, SEPTEMBER 6, 2011 Le Gall 12:00–12:15 Pruritus in cutaneous T-cell lymphomas, Nicolas 09:00-10:30 Biological and physiological aspects (1) (IP13–16) Meyer Chairs:Earl Carstens and Satoshi Takeuchi 12:15–12:30 Pruritus and amyloidosis, Akio Tanaka 09:00–09:15 Neurotrophins and itch, Martin Schmelz 09:15–09:30 The mechanism by which cathepsin S triggers PAR2 12:30–14:00 Lunch and Poster Session activation, Ethan Lerner 09:30–09:45 Inhibitory neurons of the dorsal horn play a crucial 14:00–15:30 Clinical and Pathophysiological Aspects (2) role in dampening itch, Sarah Ross (IP09–10) 09:45–10:00 Mrgprs are itch receptors, Xinzhong Dong Chairs: Ethan Lerner and Masutaka Furue 10:00–10:30 Free communications (FC09–10) 14:00–14:15 Pruritus in human AD-mechanisms and A role of matrix metalloproteinase-8 in dermal managements of intractable itch, Kenji Takamori nerve growth: Implications for possible application 14:15–14:30 Pruritus in canine atopic dermatitis, Thierry Olivry to pruritus involving skin nerve from in vitro 14:30–15:30 Free communications (FC03–06) models, Mitsutoshi Tominaga, Suhandy Tengara, Topically applied semaphorin 3A ointment Atsuko Kamo, Kenji Takamori inhibits scratching behaviors and improves Functional differentiation between histamine skin inflammation in NC/Nga mice with atopic and cowhage itch in humans, Roman Rukwied, dermatitis. Osamu Negi, Mitsutoshi Tominaga, Benjamin Weinkauf, Martin Dusch, Jasper van der Kenichi Taneda, Atsuko Kamo, Suhandy Tengara, Ham, Justus Benrath, Matthias Ringkamp, Martin Kenji Takamori Schmelz Acta Derm Venereol 91 6th International Workshop for the Study of Itch – September 4–6, 2011, Brest, France 613 10:30–11:00 Coffee Break and Poster Session Central modulation of itch by distraction – a functional MRI study, Astrid Stumpf, Bettina 11:00–12:30 Biological and Physiological Aspects (2) (IP17–20) Pfleiderer, Gudrun Schneider, Gereon Heuft, Chairs: Sonja Ständer and Kenji Takamori Martin Schmelz, Ngoc Quan, Phan, Sonja Ständer, 11:00–11:15 VGLUT2+ neurons and itch, Klas Kullander Markus Burgmer 11:15–11:30 Role of spinal neurotransmitter receptors in itch, Ferda Cevikbas 15:00–16:30 Treatments (IP21–24) 11:30–11:45 Animal models of itch sensitization, Earl Carstens Chairs: Elka Weisshaar and Toshiya Ebata 11:45–12:00 Itch sensitization in humans: Inflammatory and non- 15:00–15:15 Itch and acupuncture, Florian Pfab inflammatory mechanisms, Akihiko Ikoma 15:15–15:30 Substance P as a target in chronic pruritus therapy, 12:00–12:30 Free communications (FC11–12) Sonja Ständer Punctate chemical stimulation with histamine 15.30–16.30 Free Communications (FC17–20) and capsaicin activates a subset of polymodal Skin analysis by 5D intravital multiphoton nociceptors in monkey, Matthias Ringkamp, tomography in patients with atopic dermatitis Jasenka Borzan, Kaitlin Schaefer, Timothy Hartke, treated with aprepitant – a case study, Ngoc Quan Richard Meyer Phan, Sonja Ständer, Valentina Dimitrova, Dieter Warming enhances serotonin-evoked itch via Metze, Stefan W. Schneider, Volker Huck TRPV4, Tasuku Akiyama, Margaret Ivanov, The effects of an opioid antagonist on the itch- Masaki Nagamine, Mirela Carstens, Akihiko scratch-cycle: A psychophysical and fMRI study, Ikoma, Ferda Cevikbas, Jon Levine, Martin Clemens Forster, Rebekka Vogelgsang, Verena Steinhoff, Earl Carstens Vierow, Arnd Dörfler, Hermann O. Handwerker Topical therapy with a new Cooling Compound® in 12:30–14:00 Lunch and Poster Session patients with chronic pruritus, Matthias Augustin, Ngoc Quan Phan, Christine Blome, Gitta Neufang, 14:00–15:00 Biological and Physiological Aspects (3) Sonja Ständer Free communications (FC13-16) 16:30–16:45 How effective are placebos and vehicles in relieving Mechanisms of sensory effects of tacrolimus, Ulysse the itch of atopic dermatitis: A meta-analysis of Pereira, Nicholas Boulais, Jean-Pierre Pennec, published literature, Alan Fleischer Laurent Misery 16:45–17:00 Perspectives in itch treatment, Gil Yosipovitch Autotaxin is a novel diagnostic marker for intrahepatic cholestasis of pregnancy, Andreas 17:00–17:30 General discussion (IP25–26) E. Kremer, Peter H. Dixon, Carrie Ris-Stalpers, Chairs: Ethan Lerner and Laurent Misery Victoria Geenes, Jenny Chambers, Joris A. van 17:00–17:15 European guidelines for chronic pruritus, Elke der Post, Catherine Williamson, Ulrich Beuers, Weisshaar Ronald P. J. Oude Elferink 17:15–17:30 The bibliometrics of itch, Jeffrey Bernhard BAM8-22 peptide induces histamine-independent sensory responses in humans, Parul Sikand, Xinzhong Dong, Robert LaMotte Acta Derm Venereol 91 614 6th International Workshop for the Study of Itch – September 4–6, 2011, Brest, France POSTERS tina Schut; Alexander Claßen; Katharina Reinisch; Uwe Gieler; Jörg Kupfer PP01: Otis (Option Tool for Itching Scalp): An aid tool for the manage- PP26: Itch Occurring with chronic wounds, Julia Paul ment of itchy scalps, Catherine Oliveres-Ghouty; Charles Taieb PP27: A qualitative assessment questionnaire for pruritus, Emilie Bre- PP02: Development of a questionnaire assessing the burden of pruritus, naut; Karen Talour; Laurent Misery Charles Taieb PP28: Epidermal and dermal innervation in keloids, Hong Liang Tey; PP03: Epidemiology of pruritus in France, Laurent Misery; Charles
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  • Urticaria and Angioedema

    Urticaria and Angioedema

    Urticaria and Angioedema This guideline, developed by Robbie Pesek, MD and Allison Burbank, MD, in collaboration with the ANGELS team, on July 23, 2013, is a significantly revised version of the guideline originally developed by Jeremy Bufford, MD. Last reviewed by Robbie Pesek, MD September 14, 2016. Key Points Urticaria and angioedema are common problems and can be caused by both allergic and non- allergic mechanisms. Prompt diagnosis of hereditary angioedema (HAE) is important to prevent morbidity and mortality. Several new therapeutic options are now available. Patients with urticaria and/or angioedema should be referred to an allergist/immunologist for symptoms that are difficult to control, suspicion of HAE, or to rule out suspected allergic triggers. Definition, Assessment, and Diagnosis Definitions Urticaria is a superficial skin reaction consisting of erythematous, raised, blanching, well- circumscribed or confluent pruritic, edematous wheals, often with reflex erythema.1-3 Urticarial lesions are typically pruritic, and wax/wane with resolution of individual lesions within 24 hours. Angioedema is localized swelling of deep dermal, subcutaneous, or submucosal tissue resulting from similar vascular changes that contribute to urticaria.1,2 Angioedema may be pruritic and/or painful and can last for 2-3 days depending on etiology.3 1 Urticaria alone occurs in 50% of patients and is associated with angioedema in 40% of patients. Isolated angioedema occurs in 10% of patients.1,2 Hereditary angioedema (HAE) is a disorder involving defects in complement, coagulation, kinin, and fibrinolytic pathways that results in recurrent episodes of angioedema without urticaria, usually affecting the skin, upper airway, and gastrointestinal tract.4 In children, acute urticaria is more common than chronic forms.
  • Pathophysiology and Treatment of Pruritus in Elderly

    Pathophysiology and Treatment of Pruritus in Elderly

    International Journal of Molecular Sciences Review Pathophysiology and Treatment of Pruritus in Elderly Bo Young Chung † , Ji Young Um †, Jin Cheol Kim , Seok Young Kang , Chun Wook Park and Hye One Kim * Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University, Seoul KS013, Korea; [email protected] (B.Y.C.); [email protected] (J.Y.U.); [email protected] (J.C.K.); [email protected] (S.Y.K.); [email protected] (C.W.P.) * Correspondence: [email protected] † These authors contributed equally to this work. Abstract: Pruritus is a relatively common symptom that anyone can experience at any point in their life and is more common in the elderly. Pruritus in elderly can be defined as chronic pruritus in a person over 65 years old. The pathophysiology of pruritus in elderly is still unclear, and the quality of life is reduced. Generally, itch can be clinically classified into six types: Itch caused by systemic diseases, itch caused by skin diseases, neuropathic pruritus, psychogenic pruritus, pruritus with multiple factors, and from unknown causes. Senile pruritus can be defined as a chronic pruritus of unknown origin in elderly people. Various neuronal mediators, signaling mechanisms at neuronal terminals, central and peripheral neurotransmission pathways, and neuronal sensitizations are included in the processes causing itch. A variety of therapies are used and several novel drugs are being developed to relieve itch, including systemic and topical treatments. Keywords: elderly; ion channel; itch; neurotransmission pathophysiology of itch; pruritogen; senile pruritus; treatment of itch 1. Introduction Citation: Chung, B.Y.; Um, J.Y.; Kim, Pruritus is a relatively common symptom that anyone can experience at any point in J.C.; Kang, S.Y.; Park, C.W.; Kim, H.O.