CURRICULUM VITAE – MICHAEL ASCHNER

Part I. ADMINISTRATIVE, RESEARCH, SERVICE, PUBLICATION INFORMATION

CURRENT ACADEMIC TITLE: Harold and Muriel Block Chair in Molecular Pharmacology; Professor of Molecular Pharmacology, Neuroscience, Pediatrics; Investigator, Rose F. Kennedy Intellectual and Developmental Disabilities Research Center; Member, Nathan Shock Center of Excellence in the Basic Biology of Aging

ADDRESS: BUSINESS: Department of Molecular Pharmacology Room 209 Forchheimer Albert Einstein College of Medicine of Yeshiva University Jack and Pearl Resnick Campus 1300 Morris Park Avenue, Bronx NY 10461

Telephone: 718.430.2317 E-mail: [email protected]

RESIDENCE: 640 West 237th Street Apartment 8C Bronx, NY 10463

PERSONAL INFORMATION: BIRTHPLACE AND DATE: Jerusalem, Israel; November 11, 1955 CITIZENSHIP: Dual: USA and Israel CHILDREN: Yael - 35; Eitan – 30; Nadav - 29; Amir - 26

EDUCATION: 1979-1980 University of Rochester, Rochester, NY, BS, Natural 1980-1983 University of Rochester, School of Medicine and Dentistry, Rochester, NY - MS, Anatomy 1983-1985 University of Rochester, School of Medicine and Dentistry, Rochester, NY - Ph.D., Neurobiology and Anatomy Dissertation Title: Methylmercury’s Effects on Axonal Transport under Acute and Systemic Exposure Patricia M. Rodier, Ph.D., Thesis Advisor

POSTDOCTORAL TRAINING: 1985-1987 Environmental Health Sciences Center, Division of Toxicology, University of Rochester, School of Medicine and Dentistry, Rochester, NY. Thomas W. Clarkson, Ph.D., Advisor

SPECIAL TRAINING: Paratrooper (35th Brigade, Battalion 202)

Michael Aschner Curriculum Vitae

EMPLOYMENT:

2012-2013 Senior Faculty Fellow, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN 2011-2013 Director, Center of Molecular Toxicology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 2011-2013 Director, Training Grant in Molecular Toxicology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 2007-2008 Adjunct Professor, Department of Pharmacology and Environmental Toxicology, University of Madras, Chennai, . 2005- Director, Division of Pediatric Toxicology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 2004-2013 Gray E. B. Stahlman Chair in Neuroscience Professor, Departments of Pediatrics and Pharmacology, and Senior Scientist at the Kennedy Center for Research on Human Development, Member Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 2003-2007 Adjunct Professor, Department of Morphology, Ben-Gurion University of the Negev, Beer-Sheba, Israel. 2004-2007 Adjunct Professor, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 1999-2004 Professor, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 1994-1999 Associate Professor, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 1992-1994 Associate Professor, Department of Pharmacology and Toxicology, Albany Medical College, Albany, NY 1988-1992 Assistant Professor, Department of Pharmacology and Toxicology, Albany Medical College, Albany, NY

HONORS AND AWARDS: 1985-1987 “Young Investigator Travel Award”, Teratology Society 1988 Albany Medical College Nominee for the Alexandrine and Alexander L. Sinsheimer Scholar Award 1991 Albany Medical College, Wiggers’ Travel Award May 1996 Diplomat, American Board of Forensic Examiners April 2002 Certificate of Merit, American Chemical Society, for first paper presentation which was judged outstanding for material content and for manner of presentation. June 1997-present Fellow (Elected), Academy of Toxicological Sciences, USA (recertified by Board of Trustees, 2002 and 2007) July 2006-present Member, Faculty of 1000, Toxicology Section, Pharmacology and Drug Discovery Faculty, [email protected] April 2008 Recipient, Vanderbilt University Medical Center (VUMC) Postdoctoral Association (PDA) 2nd Annual Postdoc Mentor of the Year Award.

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September 2009 U.S. Food and Drug Administration, Advisory Committee Service Award, National Center for Toxicological Research. March 2011 Merit Award, Society of Toxicology, in recognition of distinguished contributions to toxicology throughout an entire career in research, teaching, regulatory activities, consulting and service to the Society. August 30, 2012 Honorary Visiting Professorship, Fourth Military Medical School, Xi’an, China. November, 2012 Fellow (Elected), American Association for the Advancement of (AAAS), Pharmaceutical Sciences Section. March 2016 Career Achievement Award, Metal Specialty Section, Society of Toxicology

OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: AD HOC REVIEWER: Acta Neurobiologiae Experimentalis Alcoholism: Clinical and Experimental Research American Journal of Physiology Annals of the New York Academy of Sciences Archives of Environmental Contamination and Toxicology Biochemical Pharmacology Bioelectromagnetics Biology of Trace Element Research Brain Behavior and Immunology Brain Research Brain Research Bulletin Cellular and Molecular Biology Cellular and Molecular Life Sciences Chemical Research in Toxicology Clinica Chimica Acta Comparative Biochemistry and Physiology Environmental Bioindicatrs Environmental Health Perspectives Environmental Pollution Environmental Research Environmental Toxicology and Pharmacology Experimental Neurology Fundamental and Applied Toxicology (through 1997) Glia Human and Ecological Risk Assessment (HERA) Human and Experimental Toxicology International Journal of Developmental Neuroscience

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

AD HOC REVIEWER: International Journal of Toxicology Journal of Biological Chemistry Journal of Biological Inorganic Chemistry Journal of Cellular Physiology Journal of Cerebral Blood Flow and Metabolism Journal of Environmental Analytical Chemistry Journal of Histochemistry and Cytochemistry Journal of Neurochemistry Journal of Neurological Sciences Journal of Neuroprotection and Neurodegeneration Journal of Neuroscience Journal of Neuroscience Research Journal of Pharmacology and Experimental Therapeutics Journal of Radiation Biology Journal of Toxicology and Environmental Health Life Sciences Molecular and Cellular Biochemistry Neurobehavioral Toxicology and Teratology Neurochemistry International Neurodegeneration NeuroImage Neuroscience Letters Neuropharmacology Neuroscience Neuroscience Research Communications Neurobiology of Aging Neurotoxicology Neurotoxicity Research Neurotoxicology and Teratology Pharmacology and Toxicology Physiology and Behavior PLoS One Science of the Total Environment Teratology Toxicology and Applied Pharmacology Toxicology Toxicology Letters Toxicological Sciences The Scientific World Journal Therapeutic Drug Monitoring Trends in Pharmacological Sciences (TIPS)

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

BOOK PROPOSAL REVIEWS: 1996 Multimedia Criteria for Iron and Compounds, CRC Press 2007 Neuropathology for Toxicologists, John Wiley and Sons

MEMBER EDITORIAL BOARDS: 1994-1995 Editorial Board, Neurotoxicology 1995-present Associate Editor, Neurotoxicology 1995-1998 Editorial Board, Fundamental & Applied Toxicology (FAAT). 1998-2004 Editorial Board, Toxicological Sciences (formerly FAAT). 1998-present Editorial Board, inScight (Academic Press) 1999-present Editorial Board, Acta Neurobiologiae Experimentalis 2002-2012 Editorial Board (2002-2005) and Associated Editor (2005- present), the Scientific World Journal, Toxicology and Neuroscience Sections. 2004-present Associate Editor, Toxicological Sciences 2005-2006 Associate Editor, Journal of Alzheimer’s disease 2005-present Editorial Board, Clinical Nutrition 2006-2015 Editorial Board, Biology of Trace Element Research 2006-present Editorial Board, Journal of the Centre for Scientific Investigations and Training, Oweri, Nigeria 2006-present Editorial Board, Alcohol 2007-present International Referee Board, Acta BioMedica 2007-present Editorial Board, Environmental Bioindicators 2000-2015 Editorial Board, Toxicology 2008-2012 Editorial Board, Journal of Toxicology 2008-present Editorial Board, Journal of Biomedicine and Biotechnology 2009-present Editorial Board, Toxins 2009-present Editorial Board, American Journal of Clinical Neurology 2010-present Editorial Advisory Board, Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR 2010-present Associate Editor, Journal of Environmental Neuroscience and Biomedicine (2010-present) 2011-present Editorial Board, Journal of Clinical Toxicology 2011-present Associate Editor, Frontiers in Toxicogenomics 2011-2015 Editorial Board, Neurotoxicology and Teratology 2011-present Editorial Board, Publishing Group 2011-present Associate Editor, Neurochemical Research 2012-present Editor, BioMed Central Pharmacology and Toxicology 2012-present Editorial board of Journal of Trace Analysis in Food and Drugs 2012-present F1000 Research's Editorial Board 2013-present Editorial Board, Toxics 2013-present Associate Editor, Biochemistry and Pharmacology 2014-present Section-Editor, Frontiers in Toxicogenomics 2014-present Associate Editor, Toxicology Reports 2014-present Editorial Board, Chemical Research in Toxicology 2015-present Editorial Board, Advances in Neurobiology 2016-present Founding Editor of Advances in Neurotoxicology (with Dr. Lucio Costa) 2017-present Editorial Board, Archives of Industrial Hygiene and Toxicology

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

RESEARCH REVIEW COMMITTEES/CONSULTS: 1986 Member “Working Group”, Rochester Conference on Biological Monitoring, University of Rochester 1988 Ad hoc reviewer, Metallobiochemistry Study Section, NIH 1991-1992 Ad hoc reviewer, Scientific Review, The Welcome Trust 1992 Consultant (unpaid), Lead Screening in Pregnancy, American College of Obstetrics and Gynecology May 1995 Site-Visitor, NIGMS 1995-1996 Ad hoc reviewer, Technical Review Panel, U.S. EPA Nov. 1996 Ad hoc reviewer, International Human Frontier Science Program (HFSP), Bureaux Europe, Strasbourg, France March 1997 Reviewer, Special Emphasis Panel, NIGMS April 1997 Reviewer, Special Emphasis Panel, NIEHS April 1997 Ad hoc reviewer, International Programme on Chemical Safety (IPCS), WHO May 1997 Reviewer, Neurological Foundation of New Zealand Aug.-Oct. 1997 Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC) 1997-2004 Member (1997-2001) and Consultant (2001-2004), Technical Advisory Panel on the Health Effects of Methylcyclopenta- dienyl Manganese Tricarbonyl, Chemical Industry Institute of Toxicology, Research Triangle Park, NC 1997-2002 Advisory Committee Member, Research Infrastructure in Minority Institutions (RIMI), Winston-Salem State University, Winston-Salem, NC Oct. 1997 Ad hoc reviewer, NIH Alcohol and Toxicology 4 Study Section Nov. 1997 Reviewer, National Center for Toxicological Research (NCTR) Research Scientist Panel, Washington, DC Nov. 1997 Ad hoc reviewer, International Human Frontier Science Program (HFSP), Bureaux Europe, Strasbourg, France Jan. 1998 Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC) Feb. 1998 Ad hoc reviewer, National Science Foundation (NSF) Feb. 1998 Ad hoc reviewer, Technical Review Panel, U.S. EPA May 1998 Ad hoc reviewer, Alcohol and Toxicology 3 Study Section, NIH July 1998 Ad hoc reviewer, Technical Review Panel, U.S. EPA July 1998 Reviewer, Chemistry and Related Sciences Special Emphasis Panel, Alcohol and Toxicology 4 Study Section, NIH July 1998 Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC) 1998-2004 Member, Scientific Advisory Group (SAG) of the International Manganese (Mn) Institute, Paris, France Oct. 1998 Ad hoc reviewer, International Human Frontier Science Program (HFSP), Bureaux Europe, Strasbourg, France. 1998 International referee, Neurological Foundation of New Zealand December, 1998 Consultant, Novartis, Crop Protection Division, Greensboro, NC 1998-2002 Member, Alcohol and Toxicology 3 Study Section, NIH January, 1999 Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC)

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

RESEARCH REVIEW COMMITTEES/CONSULTS: 1999 Biomedical Consultant, United States - Israel Binational Science Foundation, Jerusalem, Israel 1998-2001 Member, Committee on Health Effects Associated With Exposures Experienced During the Gulf War, Institute of Medicine, National Academy of Sciences, Division of Health Promotion and Disease Prevention April 1999 Ad hoc reviewer, Medical Research Council of Canada June 1999 Member, Review Committee, Department of Economical Affairs, Office of Research, Milan, Italy 1999-2000 Member, Committee to Review EPA’s maximum Contaminant Level Goal for Copper in Drinking Water, National Research Council, National Academy of Sciences May 1999 Ad hoc Reviewer, Texas A & M University pilot projects July 1999 Ad hoc member, Technical Qualifications Board (TQB), U.S. EPA August 1999 Ad hoc Reviewer, Research Grants Council of Hong Kong, China, University Grants Committee October 1999 Ad hoc Reviewer, National Institute of Environmental Health Sciences (NIEHS), Superfund Site Grant Proposals October 1999 Ad hoc Reviewer, National Science Foundation, BIO/IBN Program October 1999 Ad hoc Reviewer, The Welcome Trust, London, UK November 1999 Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC), review of draft toxicological profile document on manganese work assignment 20 under ATSDR contract 205-93-0641 2000-2001 Member, Committee to Review Navy's Proposed Submarine Escape Action Levels (SEALs) for Selected Chemicals, National Research Council, National Academy of Sciences March 2000 Member, Special Emphasis Panel, NIEHS/NS, RFA ES 00- 002. The Role of Environment in Parkinson’s disease, NIEHS, Research Triangle Park, NC May 2000 External Reviewer, National Academy of Science, Committee on Toxicological Effects of Mercury, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council, National Academy Press, Washington DC October 2000 Peer reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control (CDC) November 2000 Member, SBIR Special Emphasis Panel ZRG1 SSS-3 10 B, NIEHS, Chevy Chase, MD March 2001 Chair, Special Emphasis Panel, NIH IFCN1-04 March 2001 Member, SBIR Special Emphasis Panel ZRG1 SSS-3 10 B, NIEHS, Gaithersburg, MD. March 2001 Reviewer, National Alliance for Research (NAAR), Princeton, NJ May 15, 2001 Reviewer, Special Emphasis Panel, NIH ZEH-D-RC, NIEHS, Research Triangle Park, NC

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

RESEARCH REVIEW COMMITTEES/CONSULTS: June 27, 2001 Member, SBIR Special Emphasis Panel ZRG1 SSS-3 10 B, NIEHS, Chevy Chase, MD July 20, 2001 Chair, Special Emphasis Panel, NIH IFCN1-03 C (telephone conference) July 2001 Reviewer, EPA Special Study Section, Postdoc Applications July 2001 Peer reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC), Program Announcement Number 01037 August 2001 Reviewer, RfP-NT-01-01: Indicators of Damage to the Developing Nervous System, American Chemical Council, Arlington, VA August 2001 External Reviewer, National Academy of Science, Committee on Thimerosal and Neurodevelopmental Outcomes, Institute of Medicine Immunization Safety Review Committee, National Academy Press, Washington DC October 9, 2001 Reviewer, Special Emphasis Panel, NIH RFA ES 01-001, Transition into Independent Positions (TIP), NIEHS, Research Triangle Park, NC October 30, 2001 Reviewer, Special Emphasis Panel, NIH IFCN1-03 C (telephone conference) October 2001 – March 2002 Chair, Distinguished Investigator Award Committee, Neurotoxicology Specialty Section, Society of Toxicology December 13-14, 2001 Reviewer, Special Emphasis Panel, NIH RFA ES 01-006, Developmental Toxicology Exploratory Research Grants (R21), NIEHS, Research Triangle Park, NC Dec. 2001 - April 2002 Consultant to Health Canada, Review of Manganese Toxicokinetics, Ottawa, ON, Canada. February 2002 Reviewer, Proposal for Conference and Meetings, New York Academy of Sciences, New York, NY March 5-6, 2002 Peer Reviewer, EPA's Revised Draft, Perchlorate Environmental Contamination: Toxicological Review and Risk Characterization, Sacramento, CA June 12-13, 2002 COBRE Special Emphasis Panel, National Center for Research Resources (NCRR), Bethesda, MD July 2002 – June 2003 Chair, Alcohol and Toxicology (ALTX) 3 Study Section, NIH August 2002 Consultant, Midwest Consulting Services, South Bend, IN September 2002 Reviewer, March of Dimes, Basil O’Connor Research Award September 2002 Reviewer, EPA Special Study Section, Postdoctoral Applications September 2002 Peer reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC), Office of the Associate Administrator for Science, Atlanta, GA September 2002 Reviewer, Center for the Neurobehavioral Study of Alcohol (CNSA), Wake Forest University School of Medicine, Winston- Salem, NC 2002-2003 Consultant, Bayer CropSciences, Research Triangle Park, NC

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

RESEARCH REVIEW COMMITTEES/CONSULTS: 2002-2004 Consultant, Phillips, Lytle, Hitchcock, Blaine, and Huber, Buffalo, NY Nov. 2002-April 2004 Consultant, Ranier, Gayle, and Elliot, Lake Charles, LA January 2003 Reviewer, Occupational Exposure Limits Criteria Document for Manganese, prepared by the Institute of Environmental Health (IEH) and the Institute of Occupational Medicine (IOM), United Kingdom. January - October 2003 Consultant, Smith, Anderson, Blount, Dorsett, Mitchell and Jernigan, Raleigh, NC February 2003 Reviewer, Postdoctoral Grant Proposal, EPA. March 2003 Peer Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC) Atlanta, GA June 11-12, 2003 Member, Pediatric Advisory Committee of the Anti- Inflammatory Drugs, Food and Drug Administration, Gaithersburg, MD. August 7, 2003 Peer Reviewer, Environmental Health, Health Services, and Toxicology Research, program Number 03040, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC), Atlanta, GA August 2003 Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC), review of draft toxicological profile document on tin work assignment 20 under ATSDR contract 200-1999-00058 Sept. 29 – Oct. 1, 2003 Invited Expert, Perchlorate State of the Science Symposium (PS3), The University of Nebraska, Center for Environmental Toxicology, Omaha, NE Oct. 2003 – 2013 Member, Steering Committee Manganese Health Research Program (MHRP), Army Environmental Quality , PE #603779A – Demonstration and Validation. January 14 – 15, 2004 External Reviewer, Neurotoxicology Program, National Center for Toxicological Research (NCTR), Food and Drug Administration, Pine Bluff, AR (last minute change in schedule precluded my physical participation in the site visit; a written review was submitted). Jan. – Feb. 2004 Consultant, Cranfill, Sumner and Hartzog, L.L.P., Raleigh, NC February 2004 Reviewer, Interim Report #8 on Spacecraft Water Exposure Guidelines, National Research Council of the National Academics, Washington, DC. February 2004 Consultant, MetaPhore Pharmaceuticals, Inc., St. Louis, MO April, 2004 External Reviewer, Life Sciences and Biotechnology Institute (LSBI) Seed Grants, Mississippi State University, MS. April 4, 2006 Chair, Special Emphasis Panel Review of Superfund Basic Research Program (SBRP) supplement applications, NIEHS. April 7, 2004 Special Emphasis Panel, ZES1 LKB-E K2 1, K23 Review Panel, National institute of Environmental Health Sciences (NIEHS).

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

RESEARCH REVIEW COMMITTEES/CONSULTS: April 20, 2004 Special Emphasis Panel, ZES1 SET-A S1, Superfund Basic Research Program (SBRP), Conference Support 2004-2005, National institute of Environmental Health Sciences (NIEHS) June 21-22, 2004 Member, Expert Panel Review, the Risk Science Institute (RSI) of the International Life Sciences Institute (ILSI), Washington, DC September, 2004 Ad hoc reviewer, Health Implications of Perchlorate Ingestion, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council, National Academy of Sciences, Washington, DC: National Academy Press, 2004. October, 2004 Ad hoc member, Technical Qualifications Board (TQB), U.S. EPA, Research Triangle Park, NC December, 2004 Ad hoc member, Technical Qualifications Board (TQB), NIOSH, CDC, Morgantown, WV. January 24, 2005 Reviewer, Eastern Research Incorporated, Teratologic Evaluation of FDA 71-33 (Stannous Chloride) February 2005 Consultant, Wallace and Graham, Salisbury, NC February 4-6, 2005 Member, the White Matter Think Tank, Cure Autism Now (CAN), Malibu, CA April 26, 2005 Ad hoc member, Technical Qualifications Board (TQB), U.S. EPA, Research Triangle Park, NC April, 2005 Consultant, Womble, Carlyle, Sandridge and Rice, Winston- Salem, NC May 4-5, 2005 Chair, External Advisory Committee, Collaborative Centers for Parkinson's Environmental Research (CCPDER) Program, the National Institute of Environmental Health Sciences (NIEHS), Asilomar Conference Grounds, Pacific Grove, CA May 16, 2005 National Institute of Environmental Health Sciences Center, Grant Pilot Project Review, Harvard School of Public Health. July 2005-2008 Consultant, development of pre- and post-exposure neural protectants against organophosphorous compounds Biomedical Technology, CFD Research Corporation, Huntsville, AL July 2005 Ad hoc reviewer Hobbs/Marino proposal, Kennedy Center, Vanderbilt University Medical Center, Nashville, TN August 2005 Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC), review of draft toxicological document on Response Inhibition at 8 and 9 ½ Years of Age in Children Prenatally Exposed to PCBs. September 2005 Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC), review of draft protocol on Chronic Exposures to Airborne Manganese and Neurological and Respiratory Outcomes. October 2005 Reviewer, Philip Morris External Program, Research Management Group.

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

RESEARCH REVIEW COMMITTEES/CONSULTS: January 2006-2010 Member, External Advisory Board, The Wake Forest and Brigham and Women’s Center for Botanical Lipids, Wake Forest University Health Sciences, Department of Physiology and Pharmacology, Winston-Salem, NC. April 17-18, 2006 Site Visit, Review of the MHRP project on the health effects of manganese in ferroalloys workers, Zunyi Medical College, Zunyi, China. April 2006-2007 Member, External Advisory Board, Toxicology Center, Environmental and Occupational Health Sciences Institute, Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey (stepped down due to competing Vanderbilt application). May 2006-2009 Member, Scientific Advisory Board, National Center for Toxicological Research (NCTR), Food and Drug Administration (FDA), Jefferson, AR. May 2006-2008 Consultant, Neurotoxic Mechanisms of the Anti-Malarial Drug Mefloquine, CFD Research Corporation, Huntsville, AL. June 2006-2008 Member, Program Advisory Committee (PAC), National Institute of Neurological Disorders and Stroke (NINDS), Specialized Neuroscience Research Program (SNRP; 2 U54 NS041071-06) at Meharry Medical College, Nashville, TN June 2006-present Consultant, System Fundamental Characterization of Agent Neurotoxicity Using a Systems Biology Approach, CFD Research Corporation, Huntsville, AL July 2006 Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC), review of draft toxicological profile document on aluminum work assignment Task Order No. 200-2006-F-17036 under CDC contract GS-10F-0036K August 2006-2011 Consultant, the National Vaccine Injury Compensation Program, US Department of Justice and the Alliance for Quality Education, Landover, MD September 2006 Member, Joint Meeting of the Center for Radiological Health (CDRH) Dental Products Panel and the Center for Drug Evaluation and Research (CDER) Peripheral and Central Nervous System Drugs Advisory Committees, Food and Drug Administration (FDA). Safety of Dental Amalgams. September 2006-present Consultant, Rainey, Kizer, Reviere and Bell, PLC Jackson, TN. October 2006-2009 Member, Program Committee, American College of Toxicology (ACT). November 13, 2006 Member, Special Emphasis Review Panel, ZRG1 IFCN- A(03)M, National institute of Environmental Health Sciences (NIEHS). Telephone conference. January – February, 2007 Reviewer, Oklahoma State Regents for Higher Education, evaluating the Doctor of Philosophy in Cellular and Behavioral Neurobiology, as proposed by Oklahoma State University (written report).

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

RESEARCH REVIEW COMMITTEES/CONSULTS: January 2007-present Member, Scientific Committee on the Toxicology of Metals under the International Commission on Occupational Health (ICOH). January 2007 Member, Scientific Advisory Board, Superfund Basic Research Program Project, University of Florida, Gainesville, FL. March 2005 – 2008 Member, Program Committee, Society of Toxicology (SOT). March 13-14, 2007 Member, Special Emphasis Panel/Scientific Review Group 2007/05 ZES1 JAB-C (R1)(1), Research Triangle Park, NC. April 30, 2007 Special Emphasis Panel ZNS1 SRB-M (48), National Institute of Neurological Disorders and Stroke (NINDS). April 2007-May 2008 Member, Committee on Health Effects Associated With Exposures Experienced During the Gulf War, Institute of Medicine (IOM), National Academy of Sciences, Division of Health Promotion and Disease Prevention. Gulf War and Health: Depleted Uranium May 2007 Reviewer, Task Order No. 123, Contract No. 68-C-02-060, External Peer Review of the Draft Provisional Toxicity Value (PPRTV) Manuscript for 2,4-Dichlorophenol Developed for the Superfund Health Risk Technical Support Center (STSC). September 10, 2007 Panelist, Autism and the Environment, Vanderbilt University Kennedy Center for Research on Human Development, Leadership Council, Nashville, TN September 2007 Member, Environmental Subcommittee of Autism Speaks. October 11-12, 2007 Member, Neurotoxicology and Alcohol (NAL) Study Section, NIH, Washington, DC November 2-3, 2007 Site Visit, Review of the MHRP project on the health effects of manganese in ferroalloys workers, Zunyi Medical College, Zunyi, China. November 27, 2007 Member, Society of Toxicology Board of Publications Strategic Planning meeting, Reston, VA Dec, 2007-August 2008 Consultant, Development of a Drug-Delivery Device to the CNS, Physical Optics Corporation, Torrance, CA January 2008-2010 Consultant, Trackable Nanopolymer Agents for Inhibiting Endopeptidase Activity of Botulinum Neurotoxin, CFD Research Corporation, Huntsville, AL February 24-25, 2008 Member, Board of Scientific Councilors, National Institute of Environmental Health Sciences (NIEHS), review of the Laboratory of Neurobiology, Research Triangle Park, NC February 26-27, 2008 Member, National Institute of Environmental Health Sciences (NIEHS), 2008/05 ZES1 LWJ-G (CN) 1, Environmental Factors in Neurodegenerative Diseases, review of Centers for Neurodegeneration Science, Research Triangle Park, NC March 2008 Consultant, Napo Pharmaceuticals, Inc., San Francisco, CA. June 2008-2009 Consultant, Eramet, SA, Marietta, OH. August 2008 Reviewer, RFA on the Role of Environment Factors and Gene- Environment Interactions in the Etiology and Course of Autism Spectrum Disorders, Autism Speaks, New York, NY. August 2008-2011 Member, Education Committee, American College of Toxicology

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

RESEARCH REVIEW COMMITTEES/CONSULTS: August 2008-2009 Consultant, Medtronic Neuromodulation, CNS Drug Delivery Research and Development, Minneapolis, MN. September 2008 Reviewer, Spacecraft Water Exposure Guidelines for Selected Contaminants, Volume 3, National Research Council of the National Academics, Washington, DC December 2008-present Member, Restless Leg Syndrome (RLS) Foundation Scientific Advisory Board, Rochester, MN. February 2009-2011 Member, Board of Directors, Academy of Toxicological Sciences. March 2009-present Member, Scientific Committee on Neurotoxicology and Psychophysiology of the International Commission on Occupational Health (ICOH). April 2009 Member, NIEHS Special Emphasis Panel/Scientific Review Group 2009/08 ZES1 RAM-G (L9). (Internet Assisted Review). April 2009 Member, Study Section, Restless Leg Syndrome (RLS) Foundation (Telephone Grant Review). April 2009 Reviewer, Medical Research Council (MRC), United Kingdom. April 2009-present Member, External Advisory Board, P30 Environmental Health Sciences Center at Wayne State University, Detroit, MI. April 2009 Consultant, Goldberg and Segalla, White Plains, NY. April 2009 Consultant, Development of a Drug-Delivery Device to the CNS, Physical Optics Corporation, Torrance, CA. July 2009 Member, NIEHS Special Emphasis Panel/Scientific Review Group, ZRG1 IFCN-A (58) R RFA OD-09-003: Challenge Grants Panel 8. (Internet Assisted Review). August 2009 Member, National Institute of Neurological Disorders and Stroke Special Emphasis Panel 2009/10 ZNS1 SRB-W (34). (Internet Assisted Review). October 2009-2010 Member, Scientific Advisory Board, X-BYO Ltd, Budapest, Hungary; Hydros Inc, Herndon, VA November 2009-2013 Member, Steering Committee, Molecular Toxicology Center (Guengerich, PI), Vanderbilt University Medical Center, Nashville, TN 2009-2011 Member, Gordon Research Conference 2011, Mechanisms of Toxicity Steering Group. February 2010 Reviewer, Pilot Project, The Center for Environmental Exposures and Disease (CEED), Environmental and Occupational Health Sciences Institute (EOHSI), Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey and Rutgers University, NJ. April 2010 Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC), review of Toxicological Profile for Manganese, Minimum Risk Level, Task order No. 200-2009-F-30327. 2010-2013 Member, Research Funding Committee, Society of Toxicology (SOT).

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

RESEARCH REVIEW COMMITTEES/CONSULTS: May 13, 2010 Chair, ZES1 LWJ-G (LR) Study Section, National institute of Environmental Health sciences, Research Triangle Park, NC. June 2010-2013 Member, External Advisory Board, Superfund Research Program (SRP), Wayne State University, Detroit, MI December 13-14, 2010 Member, Joint Meeting of the Center for Radiological Health (CDRH) Dental Products Panel and the Center for Drug Evaluation and Research (CDER) Peripheral and Central Nervous System Drugs Advisory Committees, Food and Drug Administration (FDA). Safety of Dental Amalgams. January 19, 2011 External Examiner for Paleah Black, Ph.D. candidate in Biology (Chem & Environ Toxicol). Thesis entitled: Interactions of Dietary Antioxidants and Methylmercury on Health Outcomes and Toxicodynamics: Evidence from Developmental Rat Model Studies and Human Epidemiology. Faculty of Science, University of Ottawa, Ottawa, Canada. July 2011 Reviewer, Governor's Council for Medical Research and Treatment of Autism, Trenton, NJ October 4-6, 2011 Committee member, Center for Alternatives to Animal Testing (CAAT)-Europe workshop: Identification of Relevant Toxicants for Developmental Neurotoxicity, University of Konstanz, Konstanz, Germany. October 13, 2011 Member, Neurotoxicology and Alcohol (NAL) Scientific Review Group, NIH, Washington, DC. October 2011-2013 Vice President, International Society of Trace Element Research in Humans (elected). 2011-2012 Member, Congress Operating Committee, World Toxicology Summit and Expo, San Antonio, TX, September 17-19, 2012. January 18, 2012 Chair, the Denis O’Day Professor of Ophthalmology Endowed Chair Review Committee, Vanderbilt University Medical School, Nashville, TN April 10-13, 2012 Member, Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) meeting: Chlorpyrifos Health Effects, Environmental Protection Agency, Arlington, VA. May 2-3, 2012 External Consultant, Program in Toxicology, Oklahoma State University, Stillwater, OK May 9, 2012 External Consultant, the Institute for Prevention and Occupational Medicine of the German Social Accident Insurance Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany July 2012 – June 2016 Member, Neurotoxicology and Alcohol (NAL) Study Section, NIH October 26, 2012 Review, Pilot Project, Harvard-NIEHS Center For Environmental Health. November 7, 2012 Ad hoc member, Technical Qualifications Board (TQB), U.S. EPA December 2012-present Member, Steering Team of the Subcommittee on Translational Safety Biomarker Assessment of Neurotoxicity, ILSI Health and Environmental Sciences Institute (HESI), Washington, DC.

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OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

RESEARCH REVIEW COMMITTEES/CONSULTS: March 26-28, 2013 Review Committee Member, National Center for Environmental Research Science to Achieve R esults (STAR ) Program, EPA-G2012-STAR-F1, US Environmental Protection Agency (EPA), Development and Use of Adverse Outcome Pathways that Predict Adverse Developmental Neurotoxicity, Arlington, VA. 2013-2015 President, International Society of Trace Element Research in Humans (elected). 2013-present Scientific Advisory Board Member, International Academy of Oral Medicine and Toxicology (IAOMT). 2013-present Consultant, Bonne Bridges, Mueller Okeefe & Nichols, Los Angeles, CA. November, 2013 Reviewer, NIEHS Children’s Environmental Health Sciences Core Center Pilot Project Review, University of Wisconsin – Milwaukee. December, 2013 Reviewer, Pilot Grants, Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK IDDRC), Albert Einstein College of Medicine, Bronx, NY. 2013-present Member, External Advisory Board, Superfund Research Program (SRP), Mount Sinai School of Medicine, New York, NY. 2014-present Member, External Advisory Board, Superfund Research Program (SRP), University of Washington, Seattle, WA. 2014-present Chair and member, Science Advisory Committee, NIEHS/EPA Children's Environmental Health Center, the University of California at Davis, CA. February, 2014 Reviewer, Center for Urban Responses to Environmental Stressors (CURES) Pilot Grants, Wayne State University, Detroit, MI (web review). March, 2014 Reviewer, Special Emphasis Panel for Career Awards (K Applications), National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC (Teleconference). March, 2014 Reviewer, Michigan Bloodspot Environmental Epidemiology Project (BLEEP) Pilot reviews, University of Michigan School of Public Health, Ann Arbor, MI (mail review). March, 2014 - March 2017 Member, Awards Committee, Society of Toxicology (elected). March, 2014 Reviewer, Pilot Grants, P30 Center in Molecular Toxicology, Vanderbilt University Medical Center, Nashville, TN. May, 2014 – present Member, External Advisory Committee, Rhode Island IDeA Network of Biomedical Research Excellence (INBRE), University of Rhode Island, Kingston, RI. April, 2014 – present Member, External Advisory Committee, NIEHS P30 Center for Research on Environmental Disease (CRED), University of Kentucky, Lexington, KY. 2015 - present Member, External Advisory Committee, the NIEHS Center for Environmental Health in Northern Manhattan, Columbia University, New York, NY.

(Revised 9/26/2017) 15 Michael Aschner Curriculum Vitae

OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

RESEARCH REVIEW COMMITTEES/CONSULTS: July, 2015 Member, Special Emphasis Panel ZRG1 DKUS-C (50) R PAR 14-050: Virtual Consortium for Translational/Transdisciplinary, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC (Teleconference). September, 2015 – present Member, T32 on Children's Environmental Health Research, National Institute of Child Health and Human Development (NICHD), Mount Sinai University School of Medicine. December, 2015 Ad hoc member, National Center for Environmental Assessment’s (NCEA), Technical Qualifications Board (TQB), U.S. EPA. April, 2016 Reviewer, Alaska IDeA Network of Biomedical Research Excellence (INBRE), University of Alaska, Fairbanks, AK. May, 2016 - 2019 Treasurer-Elect (2016-2017) and Treasurer (2017-2019), Society of Toxicology. May, 2016 - 2019 Member, Council, Society of Toxicology. August, 2016 Reviewer, External Peer Review of 2-Hexanone Toxicological Profile, Reviewer, Agency for Toxic Substances and Disease Registry (ATSDR), Center for Disease Control and Prevention (CDC), Atlanta, GA. October, 2016 Reviewer, Pilot Grants, the NIEHS Center for Environmental Health in Northern Manhattan, Columbia University, New York, NY. November 2-3, 2016 Ad hoc reviewers, Systemic Injury by Environmental Exposure (Digestive, Kidney and Urological Systems Integrated Review Group), NIH Study Section, San Francisco, CA (by phone). January, 2017 – present Consultant, General Electric (GE) Healthcare Inc. and its Affiliates, 100 Results Way, Marlborough, MA February, 2017 – present Consultant, tranexemic acid (TXA) case, Wadleigh, Starr & Peters, P.L.L.C., Manchester, NH.

(Revised 9/26/2017) 16 Michael Aschner Curriculum Vitae

OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

VISITING FACULTY APPOINTMENTS: 1992 Jan Albrecht, Ph.D., Professor, Nencki Medical Research Center, Polish Academy of Sciences, Warsaw, Poland. July 1999 Sharon C. Roseman, M.S., Instructor of Biology, Lenoir-Rhyne College, Hickory, NC. Sept, 2002 – May, 2003 Tore Syversen, Professor, Norwegian University of Science and Technology, Department of Clinical Neuroscience, Faculty of Medicine, Trondheim, Norway February – April, 2003 Magdalena Zielinska, Ph.D., Instructor, Department of Neurotoxicology, Polish Academy of Sciences, Warsaw, Poland. Sept – December, 2004 Ana Paula Marreilha dos Santos, Auxiliary Professor, Faculty of Pharmacy, University of Lisbon, Portugal (recipient of Fulbright Fellowship for 3-month sabbatical). Jan 2006 – June, 2007 Lu Rongzhu, Ph.D., Associate Professor, Department of Preventive Medicine, School of Medicine, Jiangsu University, Jiangsu, PR China. August 21 – 30, 2006 Yoram Finkelstein, M.D., Ph.D., Sharei Zedek Hospital and Hebrew University, Jerusalem, Israel. September – October, 2005 Ana Paula Marreilha dos Santos, Auxiliary Professor, Faculty of Pharmacy, University of Lisbon, Portugal. September – October, 2006 Ana Paula Marreilha dos Santos, Auxiliary Professor, Faculty of Pharmacy, University of Lisbon, Portugal. August 2007 – present Eunsook Lee, Assistant Professor, Meharry Medical College, Nashville, TN August 29 – Sept 12, 2008 Yoram Finkelstein, M.D., Ph.D., Sharei Zedek Hospital and Hebrew University, Jerusalem, Israel. February-April, 2010-2012 Yoram Finkelstein, M.D., Ph.D., Sharei Zedek Hospital and Hebrew University, Jerusalem, Israel. January 2015 – 2016 Maria Rosa Chitolina, Professor, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil

UNIVERSITY COMMITTEES: ALBANY MEDICAL COLLEGE 1989-1992 Member, Graduate Curriculum 1990-1991 Member, Annual Research Fund 1990-1991 Member, Self-Study Committee on Basic Science Facilities 1999-2001 Member, Accelerated BS/MD Admissions 1992-1994 Member, Executive Graduate Studies Program (Elected by Faculty) 1993-1994 Member, Executive Committee of the Academic Governing Council 1993-1994 Member, Biomedical Program Policy & Promotions 1993-1994 Member, Medical Education Program Policy & Promotions 1993-1994 Chair, Middle States Association - Curriculum Committee 1993-1994 Member, Middle States Association - Coordinating Committee

UNIVERSITY OF ROCHESTER 1993-2003 Member, Undergraduate Admissions Network

(Revised 9/26/2017) 17 Michael Aschner Curriculum Vitae

OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

UNIVERSITY COMMITTEES: WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE 1994-present Interviewer at-Large, Medical Student Admissions 1995-1999 Faculty Representative to Neuroscience Graduate Student Body (Elected) 1995-2004 Resource Partner, Howard Hughes Problem-Based Learning Initiative 1997-1998 Chair, Biosafety and Environmental Health Committee. 1998-2001 Chair, Chemical Safety Committee 1997-2003 Member, Medical Student Admissions and Biomedical Relations Committee 1997-2000 Member, Radiation Safety Committee 1997-1998 Member, Curriculum for 2002 Phase III Committee Subcommittee on Systems Integration & Pathophysiology II 1998-2004 Member, Academic Merit Scholarship Committee 1999-2002 Member, Undergraduate Medical Education (CUME). 1999-2000 Member, Grading Committee 1999-2001 Liaison Committee on Medical Education (LCME) Self-Study Task Force, Educational Program for the MD Degree April-May, 2000 Member, Nutrition Research Center Faculty Review Panel 2000 Member, Committee to Evaluate the Interdisciplinary Graduate Program in Neuroscience 2000-2004 Member, AMA Scholarship Committee 2000-2003 Member, Graduate Council Committee (Elected by Graduate Faculty) 2000-2004 Member, Scholarship and Student Finance Committee (Sub- Committee of the Admissions Committee). 2000-2001 Member, Subcommittee, Course and Clerkship Evaluation Plan 2001-2004 Member, Chemical Safety Committee 2002-2003 Member, Outstanding Doctoral (Ph.D.) Student Award Committee 2002-2003 Member, Research Advisory Committee (RAC) to the Dean 2002-2003 Member, Research Excellence Award Committee 2002-2003 Program Evaluation Committee (Medical Curriculum) 2002-2004 Member, Bioterrorism Committee

VANDERBILT UNIVERSITY SCHOOL OF MEDICINE 2005-2013 Member, Chemical Safety Committee

ALBERT EINSTEIN COLLEGE OF MEDICINE 2014-present Member, Experimental Therapeutics Advisory Committee 2014-2016 Member, Faculty Senate 2014-2016 Member, Committee on Appointments and Tenure to Professor

DEPARTMENTAL COMMITTEES: ALBANY MEDICAL COLLEGE 1989-1992 Member, Graduate Education 1990-1991 Member, Seminar Speaker Selection

(Revised 9/26/2017) 18 Michael Aschner Curriculum Vitae

OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

DEPARTMENTAL COMMITTEES: ALBANY MEDICAL COLLEGE 1988-1994 Member, Sterling Visiting Professor 1999-2001 Member, Medical Education 1991-1994 Allied Health Teaching WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE 1994-1998 Member, Seminar Committee 1995-1997 Chair, Seminar Committee 1994-2004 Chair, Environmental Health and Safety Committee 1995-2000 Chair, Library Committee 1995-2004 Member, Graduate Studies Curriculum Committee 1995-1998 Chair, Departmental Facilities Committee 1995-1999 Member, Programmatic Area: Neuroscience 1995-1999 Member, Neuroscience Program Graduate Student Recruitment Committee 1995-2001 Co-Chair, United Way Campaign 2000-2001 Member, PTCRC Animal Space Allocation Committee 2001 Chair, Strategic Planning Committee 2003-2004 Member, Promotions and Tenure Committee 2004 Member, Research Space Committee

VANDERBILT UNIVERSITY MEDICAL CENTER 2005-2006 Department of Anesthesiology Junior Faculty Advisory/Mentoring Committee 2005-2007 Member, Membership Committee Kennedy Center for Research on Human Development 2005-2006 Member, Junior Faculty Mentoring Committee, Department of Pediatrics 2006-2008 Member, Lecture Committee, Vanderbilt Kennedy Center for Research on Human Development 2007-2008 Chair, Membership Committee, Vanderbilt Kennedy Center for Research on Human Development 2007-2013 Member, Research Compliance and Effort (RCE) Committee 2009-2013 Member, Department of Pharmacology Core Curriculum Committee 2010-2013 Member, Department of Pharmacology, Pharmacological Sciences Training Program Oversight Committee

ALBERT EINSTEIN COLLEGE OF MEDICINE 2014 Ad hoc Member, Committee on Appointments and Promotions 2014 – present Member, Graduate Executive Committee 2015-2016 Co-Chair of the Professors Committee on Appointments and Promotions 2016-2017 Chair of the Professors Committee on Appointments and Promotions 2015-2017 Member, Committee on Patents 2016 – present Member, Committee on Committee's, Faculty Senate

(Revised 9/26/2017) 19 Michael Aschner Curriculum Vitae

OTHER PROFESSIONAL APPOINTMENTS AND INSTITUTIONAL SERVICE: continued

PROFESSIONAL MEMBERSHIPS: Society of Toxicology (since 1986) American Society for Neurochemistry (since 1987) Society for Neuroscience (since 1988) International Neurotoxicology Association (since 1991) New York Academy of Sciences (1990-2000) Research Society on Alcoholism (1998-2003) Division of Environmental Chemistry, American Chemical Society (since 2002) American College of Toxicology (since 2003) Israel Society for Neuroscience (since 2005) International Society of Trace Element Research in Humans (since 2007)

PROFESSIONAL APPOINTMENTS: 1992-1994 Secretary/Treasurer, Neurotoxicology Specialty Section, SOT (Elected) 1992-1995 Member, Society of Toxicology (SOT) Placement Service 1993-1995 Chairman, SOT Placement Service (Appointed) 1995-1997 Sage Advisor, SOT Placement Service (Appointed) 1995-1996 Vice President-Elect, Neurotoxicology Specialty Section (NSS), SOT (Elected) 1996-1997 Vice President, Neurotoxicology Specialty Section, SOT (Elected) 1997-1998 President, Neurotoxicology Specialty Section, SOT, (Elected). 1998-1999 Member, Executive Committee, Neurotoxicology Specialty Section, SOT 1995-1999 Award Committee for Predoctoral and Postdoctoral Students, Neurotoxicology Specialty Section, SOT (Appointed; Chair, 1999) 1998-1999 President-Elect, International Neurotoxicology Association (Elected) 1999-2001 President, International Neurotoxicology Association (Elected). 2001-2003 Member, Executive Committee, International Neurotoxicology Association 2004-2007 Member, Publicity, Public Policy and Education Committee, American Society of Neurochemistry 2006- Member, Program Committee, American College of Toxicology 2006-2007 Member, Nomination Committee, Neurotoxicology Specialty Section, SOT 2007-2010 Member, Program Committee, Society of Toxicology 2008-2010 Member, Education Committee, American College of Toxicology (ACT) 2014-2015 President, International Society for Trace Elements Research in Humans

(Revised 9/26/2017) 20 Michael Aschner Curriculum Vitae

GRANTS: CURRENT, PENDING, AND PAST SUPPORT:

CURRENT SUPPORT: 2010-2016 NIEHS R01 ES07331 (14-21), Total Direct Costs-$1,250,000; Title: Mechanisms of Methylmercury-induced Neuronal Toxicity. M Aschner, Principal Investigator, 33.3% effort. 2012-2017 NIEHS R01 ES10563 (13-19), Total Direct Costs-$2,100,000. Title: Mechanisms of manganese neurotoxicity; M Aschner, AB Bowman, Principal Investigators, Multiple PI proposal, 20% effort. 2012-2016 The Acrylonitrile Group, Total Direct Costs-$360,000; Title: Differential Sensitivity of Astrocytes and Microglia to In Vivo Acrylonitrile Treatment. M Aschner, Principal Investigator, 10% effort. 2012-2017 NIEHS 1R01 ES020852, Total Direct Costs-$1,250,000; Title: Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing Brain. M. Aschner, Principal- Investigator, 20% effort. 2013-2016 Title: CNPq - National Council for Scientific and Technological, International cooperation; FAA Soares, Principal Investigator (University of Santa Maria, Rio Grande do Sul, Brazil); M Aschner, Co-investigator, 0% effort. 2014-2019 NIEHS 2R01 ES016931-06A1, Total Direct Costs-$1,250,000. Title: Gene- Neurotoxicant Interactions in Huntington Disease. AB Bowman, PI (Vanderbilt University Medical Center), M Aschner, Co-I, 3% effort. 2013-2017 Virtual Consortium for Translational/Transdisciplinary Environmental Research (ViCTER), supplement to R01 ES10563 (13-19), Total Direct Costs-$750,000. Title: The Role of Manganese in Restless Leg Syndrome (RLS); M Aschner, AB Bowman (Vanderbilt University Medical Center), Principal Investigators, Multiple PI proposal, 5% effort. 2015-2020 NIEHS R01 ES024756-01A1, Total Direct Costs-$289,200. Title: Mechanisms of manganese-induced impairment of astrocytic glutamate transporters. E Lee, PI (Meharry Medical College), M Aschner, Co-I, 10% effort. 2015-2017 NIEHS 1R03 ES024849, Total Direct Costs-$100,000. Title: Retinal Neurotoxicity of Manganese Exposure. Nancy Parmalee, PI, M Aschner, Co-I, 3% effort. 2015-2020 NIEHS R01 ES024812-01, Total Direct Costs-$101,920. Regulation of Manganese Homeostasis and Detoxification by SLC30A10. Somshuvra Mukhopadhyay (University of Texas at Austin), PI, M Aschner, Co-I, 5% effort. 2015-2017 NIEHS 1R21 ES025415-01A1, Total Direct Costs-$275,000. Title: Genetic Susceptibility to Manganese Neurotoxicity. M Aschner, Principal-Investigator, 10% effort. 2016-2021 NIEHS R01 ES07331 (21-26), Total Direct Costs-$1,250,000; Title: Mechanisms of Methylmercury-induced Neuronal Toxicity. M Aschner, Principal Investigator, 33.3% effort.

PENDING SUPPORT: 2015-2020 NIH ?????, Total Direct Costs-$55,590. Title: N-Modified Phosphatidylethanol- amines. S Davies, PI (Vanderbilt University Medical Center), M Aschner, Co-I, 3% effort. 2015-2020 NIGM R01??????, Total Direct Costs-$130,820. Title: Fluoroquinolone Safety: Prediction and Mechanism. B Golomb, PI (University of California at San Diego), M Aschner, Co-I, 5% effort. 2016-2018 Pan Chen?

(Revised 9/26/2017) 21 Michael Aschner Curriculum Vitae

GRANTS: CURRENT, PENDING, AND PAST SUPPORT: continued

PAST SUPPORT: 1985-1987 NIEHS ES07026, Postdoctoral Fellowship (Institutional). 1987 PHS Project # 31, P4 1RR01828-03, the Role of Methylmercury (MeHg) Transport in MeHg Toxicity. 1988-1989 BRSG S07RR05394-26, In Vitro Lead Exposure: Its Effect on Corticospinal Neuron Origin and Migration in the Rat. M Aschner, Principal Investigator, 20% effort. 1992-1994 USEPA R-819210, Total Direct Costs-$189,941, The Role of Astrocytes in Methylmercury Neurotoxicity. M Aschner, Principal Investigator, 25% effort. 1989-1995 FIRST AWARD, NIEHS 1R29 ESO5223, Total Direct Costs-$347,635, Manganese Transport across the Blood-Brain Barrier. M Aschner, Principal Investigator, 50% effort. 1996-1998 USEPA R-824087 (Renewal of R-819210), Total Direct Costs-$180,781, the Role of Astrocytes in Methylmercury Neurotoxicity. M Aschner, Principal Investigator, 25% effort. 1996-1999 NIH R01DA10467, Total Direct Costs-$336,782, AIDS, Drug Abuse and Cellular Neurotoxicity, BA Bennett, Principal Investigator, M Aschner, Co-Investigator, 5% effort. 1997-1999 NIAAA R03, Total Direct Costs-$69,808, Analysis of brain glucose metabolism by 13C NMR. CC Cunningham, Principal Investigator, M Aschner, Consultant, 0% effort (supplies only). 8-9/1999 American Physiological Society, Physiology Insights Fellowship support for Dr. Sharon C. Roseman, Instructor of Biology, Lenoir-Rhyne College, $8,600. 1999 NIAAA R01, AA11617, supplement, Total Direct Costs-$2,000, Astrocyte Mediated Ethanol Neurotoxicity. M Aschner, Principal Investigator, 0% effort. 1998-1999 Center for Investigative Neurosciences, Total Direct Costs-$12,069, Wake Forest University School of Medicine Involvement of Heavy Metals in Dopamine Neurotoxicity, KE Vrana, Principal Investigator; M Aschner, Co-Investigator, 5% effort. 1996-2000 NIEHS R01 ES07331 (01-04), Total Direct Costs-$472,629, Mechanisms of Methylmercury-Induced Neuronal Toxicity, M Aschner, Principal Investigator, 25% effort. 1995-1999 NIAAA 5T32 AA07565, Total Direct Costs-$867,843, Multi-Disciplinary Training in the Biology of Alcoholism. HH Samson, Director, M Aschner, Training Faculty, 5% effort. 1999-2000 Contract, University of California, Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA. Analysis of Astrocytes and protein Extracts from Astrocytes exposed to Methylmercury by µ-PIXE. Total Direct Costs-$14,750, M Aschner, Principal Investigator, 5% effort. 1999-2001 International Institute of Manganese, Total Direct Costs-$174,400, Manganese: Oxidative Stress and Bioenergetics, M Aschner Principal Investigator, 20% effort. 2000-2001 NIEHS R01 ES07331, Total Direct Costs-$49,974. Administrative Supplement for Microarray Studies in Environmental Health Sciences. M Aschner, Principal Investigator, 0% effort. 1996-2002 NCRC, 2 P20 RR11583, Total Direct Costs-$152,776, Research Infrastructure for Minority Institutions (RIMI) Astrocyte Gene Expression & Methylmercury Neurotoxicity, KH Tan, Principal Investigator, (Project 1) Subcontract from Winston- Salem State University; M Aschner Co-Investigator, 10% effort. 1998-2003 NIAAA R01AA11617, Total Direct Costs-$580,000, Astrocyte Mediated Ethanol Neurotoxicity. M Aschner, Principal Investigator, 30% effort.

(Revised 9/26/2017) 22 Michael Aschner Curriculum Vitae

GRANTS: CURRENT, PENDING, AND PAST SUPPORT: continued

PAST SUPPORT: 1999-2004 NIAAA 5T32 AA07565 (05-09), Total Direct Costs-$1,296,891, Multi-Disciplinary Training in the Biology of Alcoholism. HH Samson, Director, M Aschner, Training Faculty, 2% effort. 2000-2003 Syngenta, Total Direct Costs-$135,300. The Discovery of an Appropriate Animal Model for Prepubertal Toxicity Testing of Neurotoxic Agents and Chemicals that Interact with the P-Glycoprotein Active Transport System. JT Stevens, Principal Investigator; M Aschner Co-Principal Investigator, 10% effort. 2001-2003 NSF s.a., France, Total Direct Costs-$145,326. Effect of Acrylamide on Astrocyte Proliferation. M Aschner, Principal Investigator, 15% effort. 2003 NIEHS R13 ES012418, Total Direct Costs-$12,000. 9th International Neurotoxicology Association (INA) Meeting in Dresden, Germany. M Aschner, Principal Investigator, 0% effort. 2000-2003 NIEHS R01 ES07331 (05-08), Total Direct Costs-$700,000, Mechanisms of Methylmercury-induced Neuronal Toxicity. M Aschner, Principal Investigator, 30% effort. 2003-2004 NanoSonic, Inc., Total Costs-$10,000. Neurotoxicity associated with nanospheres. M Aschner, Principal Investigator, 1% effort. 2004 International Society of Neurochemistry. Total Direct Costs-$6,000. Support for young investigators to attend the Fifth International Conference on Metallothionein: Metal and Metallothionein in Biology and Medicine, Beijing China, October 10-13, 2004. M Aschner, Principal Investigator, 0% effort ($ returned; due to SARS epidemic conference was cancelled). 2001-2004 NIEHS, P32 ES07331, Total Direct Costs-$1,071,059. Multidisciplinary Training in Molecular Toxicology, AJ Townsend (Wake Forest University School of Medicine), Director; M Aschner, Training Faculty, 2% effort. 2001-2004 NIAAA 5T32 AA07565 (09-14), Total Direct Costs-~$1,350,000, Multi-Disciplinary Training in the Biology of Alcoholism. K Grant, Director (Wake Forest University School of Medicine), M Aschner, Training Faculty, 2% effort. 2004-2010 NIEHS R01 ES07331 (09-13), Total Direct Costs-$1,250,000; Title: Mechanisms of Methylmercury-induced Neuronal Toxicity. M Aschner, Principal Investigator, 20% effort. 2005 International Society of Neurochemistry. Total Direct Costs-$6,000. Support for young investigators to attend the Fifth International Conference on Metallothionein: Metal and Metallothionein in Biology and Medicine, Beijing China, October 8-12, 2005. M Aschner, Principal Investigator, 0% effort. 2005-2006 NIEHS P30 000267 Total Direct Costs-$40,000; Pilot Project from the Molecular Toxicology Center; Title: Manganese and MR Spectroscopy. V Fitsanakis, Principal Investigator; M Aschner, Co-Principal Investigator, 0% effort (no salary support). 2001-2006 NIEHS R01 ES10563 (04-07), Total Direct Costs-$750,000; Title: Blood-Brain Barrier Transport of Methylcyclopentadienyl Manganese Tricarbonyl (MMT). M Aschner, Principal Investigator, 20% effort. 2001-2005 US Army Department of Defense (DoD), DAMD17-01-1-0685, Total Direct Costs- $560,000; Title: Blood-Brain Barrier Transport of Uranium. M Aschner, Principal Investigator, 19% effort. 2001-2006 Subcontract from Afton Chemical Company, Richmond, VA and the Chemical Industry Institute of Toxicology (CIIT), Total Direct Costs-$700,000, Tier II Supplement to: The Effects of Manganese on Brain. M Aschner, Principal Investigator, 1% effort.

(Revised 9/26/2017) 23 Michael Aschner Curriculum Vitae

GRANTS: CURRENT, PENDING, AND PAST SUPPORT: continued

PAST SUPPORT: 2007-2010 DoD Phase II STTR, Total Direct Costs-$78,174. Title: A Systems Biology Approach to Enable Safe Administration of Mefloquine. J Jenkins, Principal Investigator (CDF Research Corporation); M. Aschner, Co-Investigator, 5% effort. 2006-2007 NIEHS P30 000267 Total Direct Costs-$40,000. Pilot Project from the Molecular Toxicology Center; Title: Anticholinesterase neurotoxicity is mediated by oxidative injury. D Milatovic, Principal Investigator; M Aschner, Co-Investigator, 0% effort. 2006-2007 Department of Defense. Total Direct Costs-$14,570. Title: Neurotoxic mechanisms of the anti-malarial drug mefloquine. J Jenkins, Principal Investigator (CDF Research Corporation); M. Aschner, Co-Investigator, 1% effort. 2006-2009 NIEHS, ES R21, Total Direct Costs-$275,000. Mitochondrial Oxidative Stress and Protection in Pesticide-Induced Neurotoxicity. J Cai, Principal Investigator (Vanderbilt University Medical Center); M Aschner, Co-Investigator, 5% effort. 2006-2009 1ES013730, Total Direct Costs-$275,000; Title: Brain Manganese Uptake in High Risk Neonates. J Aschner (Vanderbilt University Medical Center), Principal Investigator; M Aschner Co-Principal Investigator, 5% effort. 2009 RES017370A, Total Direct Costs-$7,500. Title: International Neurotoxicology Association 12, PA08-149, NIH Support for Conferences and Scientific Meetings; M Aschner, Principal Investigator, 0% effort. 2007-2009 Pilot Grant, Simons Foundation, Total Direct Costs-$265,000. Title: MET Receptor Tyrosine Kinase and Autism Spectrum Disorder. P Levitt, Principal Investigator (Vanderbilt Kennedy Center for Research on Human Development); DB Hood, Co-PI (Meharry Medical College); M Aschner, Consultant, 0% effort. 2007-2010 R21, Total Direct Costs-$275,000. Anticholinesterase neurotoxicity is mediated by oxidative injury. D Milatovic, Principal Investigator; M Aschner, Co-Investigator, 10% effort. 2009-2010 NIH SBIR 1R43GM087129-01, Total direct Costs-$24,730, Title: Novel Physiologically Realistic Microfluidic in vitro Blood-Brain Barrier Model. S Sundaram, Principal Investigator (CDF Research Corporation); M. Aschner, Co-Investigator, 5% effort. 2006-2011 NIEHS 1 S11 ES014156-01, RFA-ES-009, Total Direct Costs-$3,176,314; Title: Advanced Research Cooperation in Environmental Health (ARCH), Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity. Subcontract, Vanderbilt University Medical Center, Total Direct Costs- $503,254.00. DH Hood, Principal Investigator; M Aschner, Research Intensive University (RIU) Leader, 10% effort (administrative). 2006-2011 The Gerber Foundation, Total Direct Costs-$750,000; Title: Neurodevelopment and Neuroimaging in Parenterally-Fed Infants and Young Children. J Aschner (Vanderbilt University Medical Center), Principal Investigator; M Aschner Co-Principal Investigator, 5% effort. 2010-2011 The Acrylonitrile Group, Total Direct Costs-$93,000; Title: Differential Sensitivity of Astrocytes and Microglia to In Vivo Acrylonitrile Treatment. M Aschner, Principal Investigator, 5% effort. 2005-2011 Department of Defense (DoD), Total Direct Costs-$4,593,986; Title: Manganese Health Research Program (MHRP). The funds will be administered by the Vanderbilt University Medical Center, and competitively awarded to other research institutions. M Aschner, Breakdown of Aschner effort follows:

(Revised 9/26/2017) 24 Michael Aschner Curriculum Vitae

GRANTS: CURRENT, PENDING, AND PAST SUPPORT: continued

PAST SUPPORT: 2005-2011 Department of Defense (DoD), Total Direct Costs-$434,248; Title: Magnetic resonance imaging (MRI) of manganese accumulation in the rat brain associated with iron-deficiency and supplementation, Project 5, Manganese Health Research Program (MHRP). The funds will be administered by the Vanderbilt University Medical Center, and competitively awarded to other research institutions. M. Aschner, Principal Investigator, 3% effort. 2005-2011 Department of Defense (DoD) Award W81XWH-05-1-0239, Total Direct Costs- $2,672,418. Administrative Core, Manganese Health Research Program (MHRP). The funds will be administered by the Vanderbilt University Medical Center, and competitively awarded to other research institutions. M. Aschner, Principal Investigator, 10% effort. 2005-2011 Department of Defense (DoD), Total Direct Costs-$5,000; Title: Biomarkers of Early Onset of Manganese Neurotoxicities among Occupationally Exposed Chinese Workers Project 2, Manganese Health Research Program (MHRP). W Zheng (Purdue University), Principal Investigator; M Aschner consultant, 2% effort. 2005-2011 Department of Defense (DoD), Total Direct Costs-$120,000; Pilot Project; Title: Role of Toxins and Genetics in Manganese-Induced Dopamine Neuron Degeneration. R Nass (Vanderbilt University Medical Center), Principal Investigator; M Aschner Co- Principal Investigator, 8% effort. 2005-2011 Department of Defense (DoD), Total Direct Costs-$120,000; Pilot Project; Title: Developing Biomarkers for Manganese Toxicity. B. McLaughlin (Vanderbilt University Medical Center), Principal Investigator; M Aschner Co-Principal Investigator, 5% effort. 2005-2011 Department of Defense (DoD), Total Direct Costs-$120,000; Pilot Project; Title: Mechanisms of Manganese-Induced Damage at the Cell and Mitochondrial Level T Gunter (University of Rochester School of Medicine and Dentistry), Principal Investigator; M Aschner Co-Principal Investigator, 0% effort (no salary support). 2006-2012 R01 ES10563 (7-12), Total Direct Costs-$1,250,000. Title: Mechanisms of manganese neurotoxicity; M Aschner, Principal Investigator, 20% effort. 2006-2011 NIEHS, 1 R01 ES 014459-01, Total Direct Costs-$1,125,000; Title: Molecular Genetics of Manganese-Induced Dopamine Neuron Toxicity. R Nass (Vanderbilt University Medical Center), Principal Investigator; M Aschner Co-Principal Investigator, 5% effort. 2006-2011 NIEHS, ES R01, Total Direct Costs-$226,982; Title: Mitochondrial Role in Manganese Toxicity. TE Gunter (University of Rochester School of Medicine and Dentistry), Principal Investigator; M Aschner Co-Principal Investigator, 9% effort. 2006-2010 NIEHS, 1 S11 ES014156-01, RFA-ES-009, Total Direct Costs-$133,119; Title: Advanced Research Cooperation in Environmental Health (ARCH), Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity. Project 4: Mechanisms of B(a)P Induced Neurotoxicity. DH Hood (Meharry Medical College), Principal Investigator; M Aschner Co-Principal Investigator, 5% effort. 2009-2012 Proposal 2007214, Title: United States - Israel Binational Science Foundation (BSF), Total Direct Costs-$142,000, Characterization of a novel counter-irritating peptide and its mechanism of action. Wormser U (Hebrew University, Jerusalem, Israel), Principal Investigator; M Aschner, Co-Investigator, 0% effort. 2009-2012 Susan G. Komen for the Cure, #KG090434, Real Time Assessment Of Self- Reporting Chemotherapeutics For Targeted Treatment Of Metastatic Breast Cancer, O McIntyre, (Vanderbilt University Medical Center, Cancer Biology), Principal Investigator; M Aschner, Co-Investigator, 5% effort.

(Revised 9/26/2017) 25 Michael Aschner Curriculum Vitae

GRANTS: CURRENT, PENDING, AND PAST SUPPORT: continued

PAST SUPPORT: 2009-2012 NIEHS K12 grant. Title: Influence of Perinatal Exposure to Methylmercury and Bisphenol A on Neurophysiology and Neurodevelopment of Premature Infants. The Vanderbilt Environmental Health Science Scholars (VEHSS) Program, Vanderbilt University School of Medicine. Institutional Patient-Oriented Career Development Program in the Environmental Health Sciences. N Maitre, PI (Vanderbilt University Medical Center), M Aschner, Mentor, 0% effort. 2009-2012 RGA0903, Environment and Health Fund, Israel, Total Direct Costs-$283,000, Title: Organophosphates in Hula Basin: atmospheric levels, transport, degradation products and neurotoxic hazards in children following low-level long-term exposure. Y Finkelstein and Y Dubowski, Principal Investigators (Israel), M Aschner, Co- Investigator, 2% effort. 2008-2013 1R01ES016931-01, Title: Mechanisms of Gene-Environment Interactions between Manganese Exposure and the Pathophysiology of Huntington disease. A Bowman (Vanderbilt University Medical Center, Neurology), Principal Investigator; M Aschner, Co-Investigator, 5% effort. 2010-2013 5P30 ES000267-44, Center in Molecular Toxicology, Total Direct Costs-$914,899/yr, M Aschner, Principal Investigator, 20% effort. 2009-2013 5T32 ES007028-37, Training Program in Environmental Toxicology, Total Direct Costs-$546,265/yr, M Aschner, Principal Investigator, 10% effort. 2008-2013 1T32 MH 064913-06, Total Direct Costs-$4,058,131, Training in Fundamental Neuroscience. Mark Wallace, Director (Vanderbilt University Medical Center), M Aschner, Training Faculty. 2008-2013 5T32 GM 007628-31, Total Direct Costs-$3,056,737, Training in Pharmacological Sciences. H Hamm, Director (Vanderbilt University Medical Center), M Aschner, Training Faculty. 2009-2014 5T32 ES 007028-31, Total Direct Costs-$3,088,415, Training Program in Environmental Toxicology. PF Guengerich, Director (Vanderbilt University Medical Center), M Aschner, Training Faculty. 2008-2013 5T32 Training Program in Human Genetics. S Williams, Director (Vanderbilt University Medical Center), M Aschner, Training Faculty. 2007-2012 5T32 Training Program in Human Genetics. J. Haines, Director (Vanderbilt University Medical Center), M Aschner, Training Faculty. 2007-2012 Environmental Health Science Scholars Program, NIEHS (K12), Vanderbilt Physician Scientist Development (VPSD) Awards Program. N Brown, PI (Vanderbilt University Medical Center), M Aschner, Training Faculty. 2008-2013 2T32 HD 049337-01, Total Direct Costs-$1,280,605, Postdoctoral Training Program in Developmental Pharmacology. J Barnett, Director (Vanderbilt University Medical Center), M Aschner, Training Faculty. 2012-2013 3P30 ES000267-45S1, Total Direct Costs-$75,000; Title: Supplement to Molecular Toxicology Center. M Aschner, Principal Investigator, 1% effort. 2012-2013 NIEHS R01 ES07331-17S1, Total Direct Costs-$45,000; Title: Diversity Supplement for Ebany Martines-Finley, Mechanisms of Methylmercury-induced Neuronal Toxicity. M Aschner, Principal Investigator, 0% effort. 2013-2014 1R13 ES023270-01, Total Direct Costs-$15,000. Title: 14th Biennial Meeting of the International Neurotoxicology Association: The Neurodevelopmental Basis of Health and Disease in Neurotoxicology; M Aschner, Principal Investigator, 0% effort. 2010-2015 RO1HL097566. Title: Chronic progressive hypoxia-induced pulmonary hypertension in newborns. C Fike, PI (Vanderbilt University Medical Center), M Aschner, Co-I, 5% effort.

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GRANTS: CURRENT, PENDING, AND PAST SUPPORT: continued

PAST SUPPORT:

2012-2015 NIGM 2R44GM087129, SBIR, Subcontract from CFDRC, Huntsville, AL, Total Direct Costs-$, $57,935; Title: A Novel Physiologically Realistic Microfluidic In-Vitro Blood- Brain Model. M. Aschner, Co-Investigator, 5% effort. 2014 Title: Gene expression in manganese (Mn) exposed C. elegans. Total Direct Costs- $4,800. Rose F. Kennedy Intellectual and Developmental Disabilities Research Center NGEN Core Micro-Grants; M Aschner and NL Parmalee (PIs), 0% effort. 2014-2015 Albert Einstein College of Medicine, Global Health Center pilot project. Total Direct Costs-$289,200. Title: Mixed Metal Exposures and Developmental Outcomes of Children Less than 5 Years Old: Exposure to Lead and Manganese. M Markowitz, PI, M Aschner, Co-I, 0% effort. Funded, but refused by PI due to budget cut.

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BIBLIOGRAPHY:

EDITORIAL RESPONSIBILITIES: BOOKS AND JOURNALS: 1996 The Role of Glia in Neurotoxicity. Aschner M, Kimelberg HK Eds. Aschner M, Kimelberg HK. Boca Raton, FL: CRC Press, Inc., 1996.

2000 Children’s Health and the Environment. Cranmer JC, Aschner M, Bearer CF, Cory-Slechta DA, Costa LG, DeRosa CT, Goldman LR, Kirshner A, Rice DC, Slikker W, Jr, Sonawane B, Tilson HA, Weiss B, Eds. Neurotoxicology, Little Rock, AR: Intox Press, Inc, 2000.

2002 INFACON 9: Manganese Health Issues Symposium. Aschner M, Guest Editor. Neurotoxicology, Elsevier Science, Amsterdam, Netherlands, 2002.

2003 8th Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health, Brescia, Italy, June 23-26, 2002. Guest Associate Editor, Neurotoxicology Vol. 24 4-5, 2003.

2004 The Role of Glia in Neurotoxicity. Second Edition. Aschner M, Costa LG, Eds. Boca Raton, FL: CRC Press, Inc., ISBN: 0-8493-1794-0, 2004.

2005 Conference on Health Effects of Manganese: Research, Industrial Hygiene, and Clinical Issues in Occupational Exposures, New Orleans, LA, April 17-18, 2004. Guest Associate Editor, Neurotoxicology Vol. 26, 2005.

2006 Environment and Neurodevelopmental Disorders. Twenty Second (XXII) International Neurotoxicology Conference Proceedings, Research Triangle Park, NC, September 12-15, 2005. Guest Associate Editor, Neurotoxicology Vol. 27/5, 2006.

2007 Neurochemistry of Metabolic Diseases-Lysosomal Storage Diseases, Phenylketonuria and Canavan Disease. Surendran S, Aschner M, Bhatnagar M, Eds. Research Signpost, Kerala, India, ISBN: 81- 7895-267-X, 2007.

2008 Editor, Proceedings of the 11th meeting of the International Neurotoxicology Association (INA), Asilomar Conference Grounds, Pacific Grove, CA, June 10-15, 2007, Neurotoxicology, Vol. 29/3, 2008.

2010 Section Editor on Risk Assessment of Methylmercury and its Effects on Neurodevelopment. In: Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, W Slikker and C Wang, Eds. John Wiley & Sons, Malden, MA, 2010.

2010 Guest Editor, Proceedings of the 12th meeting of the International Neurotoxicology Association (INA), Ma’ale Hachamisha Kibbutz Hotel and Convention Center, Jerusalem, Israel, June 7-10, 2009. Neurotoxicology, Vol. 31, 2010.

2011 Neuromethods, Cell Culture Techniques, Series Ed. W Walz, Volume Ed. Aschner M, Sunol C, Price A. Springer Science-Business Media, ISSN: 0893-2336, 2011.

2011 Methylmercury and Neurotoxicity. In: Current Topics in Neurotoxicity, M Giampoala ed., S Ceccatelli and M Aschner Section Eds., Springer Science and Business Media, New York, NY, 2011.

2011 Associate Editor, Neurotoxicology (LG Costa, M Aschner, Assoc Eds). In: Encyclopedia of the Neurological Sciences, Second Edition, M Aminoff, RB Daroff, Editors-in-Chief, Academic Press, an imprint of Elsevier, San Diego, CA, 2011.

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BIBLIOGRAPHY:

EDITORIAL RESPONSIBILITIES: BOOKS AND JOURNALS: 2011 Toxicity of Organometal(loid)s. In: Journal of Toxicology, S Bhattacharya, A Hirner, M Aschner, T Schwerdtle, Dopp E, eds, Hindawi Publishing Corporation, New York, NY, 2011.

2014 Manganese in Health and Disease. Aschner M, Costa LG, Eds. Royal Society of Chemistry, Cambridge, UK; 2014.

2014 Environmental Links to Neurodevelopmental Disorders and Neurodegenerative Disease. Aschner M, Costa LG, Eds. Elsevier, Oxford, UK; 2014.

2014 Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK; 2014.

2014 Encyclopedia of Human Biology, Simon MI, Abelson J, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Toxicology Section. Elsevier, Oxford, UK; 2014.

MONOGRAPHS: 1994 Aschner M. The astrocyte. In: In vitro neurotoxicology: Principles, practice and paradigms. Continuing Education Course # 5, Dallas, TX: Society of Toxicology, 1994, 34-64.

1995 Aschner M. Manganese Homeostasis in the Central Nervous System. In: Proceedings on the Workshop on the Bioavailability and Oral Toxicity of Manganese. U.S. EPA Monograph, 1995:22-35.

1999 Aschner M. Molecular Mimicry of Metals. Advanced Continuing Education Course Syllabus on “Metals”. Society of Toxicology, 1999.

2000 Aschner, M. Mercury Toxicity. In: Proceedings on Mercury Toxicity Workshop. American College for Advancement in Medicine, 2000.

2001 Aschner, M. Disposition-Related Neuronal Responses: Manganese Neurotoxicity from CNS Transport to Molecular Interactions. In: Basic Continuing Education Course Syllabus on Neurotoxicology of Metals: Causes and Consequences. Society of Toxicology, 2001.

2002 Aschner, M. Acrylamide Neurotoxicity: New research on the Neurotoxicity of Acrylamide. In: SNF sa Industry Briefing Report, Regnet, Inc, Washington, DC, August 8, 2002.

2003 Aschner M. Glial cultures. In: Unfolding the Secrets in Culturing Brain Cells: Theory, Techniques, and Beyond. Continuing Education Course # 5, Salt Lake City, UT, TX: Society of Toxicology, 2003, 34-64.

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BIBLIOGRAPHY: continued

CHAPTERS IN BOOKS: 1992 Aschner M, Aschner JL, Kimelberg HK. Methylmercury neurotoxicity and its uptake across the blood- brain barrier. In: Isaacson RL, Jensen KF, Eds, The vulnerable brain: nutrition and toxins, Vol. 2, New York, NY: Plenum Publishing Corporation, 1992, 3-17.

1994 Aschner M, Aschner JL, Kimelberg HK. The role of CNS glia in neurotoxic-induced injury. In: Chang LW, Ed, Handbook of neurotoxicology, I: basic principles and current concepts, New York, NY: Marcel Dekker, 1994; 93-109.

Kimelberg HK, Aschner M. Astrocytes and their functions, past and present. In: National Institute on Alcohol Abuse and Alcoholism Research Monograph, Alcohol and Glial Cells. NIH Publication No. 94- 3742, Bethesda, MD, Monograph 27, 1994:1-40.

1995 Aschner M, Vitarella D. Glial cell cultures for neurotoxicological investigations: approaches and methodologies. In: Chang LW, Ed, Neurotoxicology: approaches and methodologies. New York, NY: Academic Press, 1995; 549-562.

Aschner M, Kimelberg HK, Vitarella D. Selective techniques designed to evaluate neurotoxicity. In: Chang LW, Ed, Neurotoxicology: approaches and methodologies. New York, NY: Academic Press, 1995; 439-444.

1996 Aschner M, Kimelberg HK. Astrocytes: Potential modulators of heavy metal-induced neurotoxicity. In: Chang LW, ed. Toxicology of metals. Boca Raton, FL: CRC Press, Inc., 1996; 587-608.

Aschner M, Kimelberg HK. Metallothionein, and physiological and pathological consequences of methylmercury accumulation in astrocytes. In: Aschner M, Kimelberg HK, Eds. The role of glia in neurotoxicity. Boca Raton, FL: CRC Press, Inc., 1996; 201-220.

Kimelberg HK, Vitarella D, Aschner M. Effects of toxins on glia in relation to vasogenic and cytotoxic edema. In: Aschner M, Kimelberg HK, Eds. The Role of Glia in Neurotoxicity. Boca Raton, FL: CRC Press, Inc., 1996; 311-334.

1997 Aschner M. Astrocytes as a target site for neurotoxicity. In: Advances in animal alternatives for safety and efficacy testing. Salem H, Katz SA, Eds, Washington, DC: Taylor and Francis, 1997; 209-221.

Aschner M. Manganese neurotoxicity and oxidative damage. In: JR Connor, Ed, Metals and oxidative damage in neurological disorders. New York, NY: Plenum Press, 1997; 77-93.

Philbert MA, Aschner M. Glial cells. In: Nervous system and behavioral toxicology, comprehensive toxicology, Vol. 11, Lowndes HE, Reuhl KR, Eds, Amsterdam: Elsevier Science, 1997; 217-236 (ALSO AVAILABLE ON CD-ROM).

1998 Aschner M. Blood-brain barrier: physiological and functional considerations. In: Handbook of developmental neurotoxicology, Slikker W, Jr, Chang LW, Eds, San Diego, CA: Academic Press, 1998; 339-351.

Kimelberg HK, Aschner M. Functions of astrocytes. In: Schipper HM, Ed, Astrocytes in brain aging and neurodegeneration, Neuroscience Intelligence Unit Series. Montreal, Paris: RG Landes Co., 1998; 15- 39.

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BIBLIOGRAPHY: continued

CHAPTERS IN BOOKS: Aschner M, Bennett BA. Astrocyte-neuron co-culturing method. In: Harry J, Tilson HA, Eds, Neurodegeneration series in methods in molecular medicine. Totowa, NJ: Humana Press, 1998; 133- 145.

1999 LoPachin RM, Jr, Aschner M. Neuronal-glial interactions as potential targets of neurotoxicant effects. In: Tilson HA, Harry J Eds, Neurotoxicology, Second Edition. Washington, DC: Taylor and Francis, 1999; 53-80.

Aschner M. Electrical resistance method for measuring volume changes in astrocytes. In: Salem H, Katz SA, Eds, Alternatives in the assessment of toxicity: theory and practice. Totowa, NJ: Humana Press, 1999; 19-35.

2000 Aschner M, Kerper LE. Transport of metals in the nervous system. In: Koropatnick DJ, RK Zalups, Eds, Molecular biology and toxicology of metals. London, UK: Taylor and Francis, 2000; 276-299.

Allen, JW, Aschner M. Astrocyte cultures for neurotoxicological studies, Unit 12.4. In: Current Protocols in Toxicology. M Maines, L Costa, D Reed, S Sassa, Eds. New York, NY: John Wiley and Sons, Inc, 2000; 12.4.1-12.4.15.

2001 Aschner M, LoPachin RM. Neurotoxic injury and astrocytes. In: J de Vellis, Ed, Neuroglia in the Aging Brain. Totowa, NJ: Humana Press, 2001; 259-274.

Aschner M, Connor JR, Dorman DC, Malecki EA, Vrana KE. Manganese. In: Neurotoxicology Handbook, Volume 1, Neurotoxicity of synthesized and natural chemical substances. EJ Massaro, Ed. Totowa, NJ: Humana Press, Inc, 2001; 195-209.

2003 Aschner M, Sekler I, Silverman Z., Zatta P. Metallothioneins in human neurodegeneration. In: Metal Ions and Neurodegenerative Diseases. P Zatta, Ed. Singapore; World Scientific Publishing Co., Ltd., 2003; 307-322.

2004 Aschner M, Sonnewald U. Impairment of neurotransmitter metabolism and function by neurotoxicants: enzyme pathways in neurons and astroglia. In: Concepts of in vitro Neurotoxicology. E Tiffany- Castiglioni, Ed. Totowa, NJ: Humana Press, Inc, 2004; 133-150.

Albrecht J, Zielinska M, Allen JW, Soldin OP, Aschner M. Taurine, the Brain and Alcohol. In: Comprehensive Handbook of Alcohol Related Pathology. Preedy VR, Watson RR, Eds.; ISBN 0125643705. San Diego, CA: Academic Press 2004.

Fitsanakis V, Garcia S, Aschner M. Manganese dynamics, distribution, and neurotoxicity: In: The Role of Glia in Neurotoxicity. Aschner M, Costa LG, Eds. Boca Raton, FL: CRC Press, Inc., 2004; 395-416.

Shanker G, Syversen T, Aschner JL, Aschner M. Astroglia and methylmercury neurotoxicity. In: The Role of Glia in Neurotoxicity. Aschner M, Costa LG, Eds. Boca Raton, FL: CRC Press, Inc., 2004; 379- 394.

Costa LG, Aschner M. Role of glia in MPTP toxicity and Parkinson's disease. In: The Role of Glia in MPTP Neurotoxicity. Aschner M, Costa LG, Eds. Boca Raton, FL: CRC Press, Inc., 2004; 439-444.

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BIBLIOGRAPHY: continued

CHAPTERS IN BOOKS: 2005 Shanker G, Syversen T, Aschner JL, Sonnewald U, Aschner M. Potential Mechanisms of Methylmercury (MeHg)-Induced Neurotoxicity: The Role of Glutamate and Reactive Oxygen Species (ROS). In: Focus in Neurochemistry Research. Columbus F, Ed. Hauppauge, NY: Nova Science Publishers Inc., 2005; 213-227.

Nordskog BK, Aschner M, Vrana KE. DNA arrays as hypothesis generators in neurotoxicity research. In: In: Genomic and Proteomic Applications in Toxicity Testing, Cunningham MJ, Ed., Humana Press, Totowa 2005.

2006 Garcia S, Syversen T, Aschner M. Interspecies Variation in Toxicity of Cholinesterase Inhibitors. In: Toxicology of Organophosphate and Carbamate Compounds. Gupta RC, Ed., San Diego, CA: Elsevier Academic Press, 2006; 145-160.

Gellein K, Syversen T, Aschner M. Trace Metal Analysis of Brain Tissue, In: HR-ICP-MS. Douthitt C, Ed. Amsterdam: Elsevier Science, 2006.

2007 Dobson AW, Aschner M. Manganese-induced oxidative stress: Truth or fiction. In: Oxidative Stress and Neurodegenerative Disorders, Qureshi GA, Parvez SH, Eds. San Diego, CA: Elsevier Academic Press, 2007; 334-350.

Sonnewald U, Syversen S, Schousboe A, Waagepetersen H, and Aschner M. Regulation of metabolism by toxic species. In: Handbook of Neurochemistry and Molecular Biology, 3rd Ed, Lajtha A, Ed. Springer-Verlag Berlin Heidelberg 2007; 569-585.

2008 Penkowa M, Hidalgo J, Aschner M. Immune and inflammatory responses in the CNS: modulation by astrocytes. In: Chapter 13, Cytokines in Demyelinized Diseases, Neuroimmune Biology. Korneva HA, Phelps C, Ed. Elsevier Academic Press, 2008; 277-288.

Philbert MA, Moser V, Richardson RJ, Aschner M. Toxic Responses of the Nervous System. In: Casarett and Doull's Toxicology: The Basic Science of Poisons, Cassarett LJ, Doull J, Klaassen CD, Eds. McGraw-Hill Medical Publication Division, New York, NY, ISBN: 1591247675 0071347216, 2008; 631-664.

Owens SE, Summar M, Aschner M. Metallothionein and Autism. In: Metallothioneins In Biochemistry And Pathology. Zatta P, Ed. Singapore: World Scientific Publishing Co, ISBN-13 978-981-277-893-2 2008; 93-115.

2009 Jiang GCT, Aschner M. Depleted Uranium. In: Handbook of the Toxicology of Chemical Warfare Agents, Gupta R, Ed. San Diego, CA: Elsevier Academic Press, 2009; ISBN 978-0-12-374484-5; 393- 406.

Milatovic D, Gupta RC, Zaja-Milatovic S, Aschner M. Brain Excitotoxicity and Oxidative Injury (in Anticholinestrase Neurotoxicity). In: Handbook of the Toxicology of Chemical Warfare Agents, Gupta R, Ed. San Diego, CA: Elsevier Academic Press, 2009; ISBN 978-0-12-374484-5; 633-651.

Hood D, Ramesh A, Aschner M. Polycyclic Aromatic Hydrocarbons Exposure from Emission Products and from Terrorist Attacks on US Targets: Implications for Systemic-Developmental Central Nervous System Toxicity. In: Handbook of the Toxicology of Chemical Warfare Agents, Gupta R, Ed. San Diego, CA; ISBN 978-0-12-374484-5; Elsevier Academic Press, 2009; 229-243.

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Aschner M, Finkelstein Y. Manganese Transport: Relationship to Iron. In 3rd International Symposium on Trace Elements in the Food Chain – Deficiency or Excess of Trace Elements in the Environment as a Risk of Health, Szilágyi M. Szentmihályi K, Eds. Working Committee on Trace Elements of the Hungarian Academy of Sciences (HAS), Institute of Materials and Environmental Chemistry of the HAS, Budapest, Hungary, 2009; ISBN 978-963-7067-19-8; 397-401.

2010 Philbert MA, Aschner M. Glial Cells. In: Nervous System and Behavioral Toxicology, Comprehensive Toxicology, Volume 13, Philbert MA, Ed. Amsterdam, Netherland: Elsevier Science, 2010; 181-198.

Aschner M, Toews A. Myelin. In: Nervous System and Behavioral Toxicology, Comprehensive Toxicology, Volume 13, Philbert MA, Ed. Amsterdam, Netherland: Elsevier Science, 2010; 199-219.

Aschner M. Manganese. In: Environmental Medicine, Ayres JG, Harrison RM, Nichols GL, Maynard RL, Eds. London, England: Hodder Arnold Press, Health Sciences, ISBN: 9780340946565, 2010; 334-335.

Erikson KM, Thompson KJ, Aschner M. Transport and Biological Impact of Manganese. In: Cellular and Molecular Biology of Metals, Second Edition, Zalups RK, Koropatnick J, Eds. Washington, DC: Taylor and Francis, 2010; 127-142.

Aschner M. Introduction to Section IV, Risk Assessment of Methylmercury and its Effects on Neurodevelopment. In: Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, Wang C and Slikker W, Jr, Eds. John Wiley and Sons, Inc, 2010; 275-278.

Farina M, Rocha JBT, Aschner M. Oxidative Stress and Methyl Mercury-Induced Neurotoxicity. In: Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, Wang C and Slikker W, Jr, Eds. John Wiley and Sons, Inc, 2010; 357-385.

Bowman A, Erikson KM, Aschner M. Manganese: The Two Faces of Essentiality and Neurotoxicity. In: Metals and Neurodegeneration, Huang S, Ed. Kerala, India: Research Signpost, Singapore, ISBN 978- 81-308-0396-8, 2010; 155-175.

Ávila DS, Benedetto A, Au C, Rocha JBT, Aschner M, Bowman AB. Manganese and Brain Function. In: Biochemical Aspects of Human Nutrition, Avigliano L, Ed. Research Signpost, Singapore, ISBN: 978- 81-7895-478-3, 2010; 197-222.

Milatovic D, Gupta RC, Zaja-Milatovic S, Barnes G, Aschner M. Involvement of Oxidative Stress in Anticholinesterase Pesticide Toxicity. In: Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology. Satoh T, Gupta R, Eds. John Wiley and Sons 2010; Hoboken, NJ, 135-147.

Finkelstein Y, Richter ED, Aschner M. Epidemiological and Clinical Studies on Acute and Chronic Organophosphate-Induced Neurotoxicity in Israel. In: In: Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology. Satoh T, Gupta R, Eds. John Wiley and Sons 2010; Hoboken, NJ, 447-456.

2011 Sidoryk-Wegrzynowicz M, Aschner M. Culture models for the study of amino acid metabolism. In: Neuromethods, Series Ed. W Walz, Volume Eds. Aschner M, Sunol C, Price A. Springer Science- Business Media, 2011, pp 417-430.

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BIBLIOGRAPHY: continued

CHAPTERS IN BOOKS: Milatovic D, Aschner M. Neuronal Oxidative Injury and Biomarkers of Lipid Peroxidation. In: Neuromethods, Series Ed. W Walz, Volume Eds. Aschner M, Sunol C, Price A. Springer Science- Business Media, 2011, pp 349-364.

Farina M, Berenguer J, Pons S, Rocha JBT, Aschner M. Introducing cloned genes into cultured neurons providing novel in vitro models for neuropathology and neurotoxicity studies. In: Neuromethods, Series Ed. W Walz, Volume Eds. Aschner M, Sunol C, Price A. Springer Science- Business Media, 2011, pp 185-222.

Ni M, dos Santos APM. Farina M, Rocha JBT, Soldin O, Rongzhu L, Aschner M. Developmental Toxicity And Molecular Changes Induced By Methylmercury Exposure. In: Reproductive and Developmental Toxicology, Gupta R, Ed. Elsevier 2011; pp 451-459.

Ávila DS, Adams M, Chakraborty S, Aschner M. Caenorhabditis elegans as a Model to Assess Reproductive and Developmental Toxicity. In: Reproductive and Developmental Toxicology, Gupta R, Ed. Academic Press, Elsevier 2011; pp 193-205.

Milatovic D, Gupta RC, Yin Z, Zaja-Milatovic S, Aschner M. Manganese. In: Reproductive and Developmental Toxicology, Gupta R, Ed. Academic Press, Elsevier 2011; pp 439-449.

Milatovic D, Zaja-Milatovic S, Breyer RM, Aschner M, Montine TJ. Neuroinflammation, Oxidative Damage and Aging. In: Reproductive and Developmental Toxicology, Gupta R, Ed. Academic Press, Elsevier 2011; pp 847-853.

Finkelstein Y, Richiter ED, Aschner M. Epidemiological Studies of Anticholinesterase Pesticide Poisoning in Israel. Satoh T, Gupta RC, Eds. John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470640500.ch31.

2012 Martinez-Finley EJ, Chakraborty S, Caito SW, Fretham S, Aschner M. C. elegans and Neurodegeneration. In: Caenorhabditis Elegans: Anatomy, Life Cycles and Biological Functions. Advances in Medicine and Biology, Vol 44. Bernhardt LV, Ed. Nova Publishing Company. 2012; pp 1- 46.

Helmcke K, Aschner M. Caenorhabditis elegans as a predictive model for methylmercury (MeHg)- induced neurotoxicity. In: Current Topics in Neurotoxicity: Methylmercury and Neurotoxicity, Ceccatelli S, Aschner M, Eds. Springer Science, 2012; pp 319-334.

Yin Z, Farina, Rocha JBT, Kaur P, Syversen T, Aschner M. Methylmercury and Glia. In: Current Topics in Neurotoxicity: Methylmercury and Neurotoxicity, Ceccatelli S, Aschner M, Eds, Springer Science, 2012; pp 271-285.

Kaur P, Aschner M, Syversen T. Methylmercury Neurotoxicity: Why Are Some Cells More Vulnerable than Others? In: Current Topics in Neurotoxicity: Methylmercury and Neurotoxicity, Ceccatelli S, Aschner M, Eds, Springer Science, 2012; pp 241-258.

Caito S, Aschner M. Heavy Metals, Behavior, and Neurodegeneration: Using Caenorhabditis elegans to Untangle a Can of Worms. In Metals in the Brain, Linert W, Kozlowski H, Eds. Springer-Verlag, Wien, 2012; pp 177-187.

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BIBLIOGRAPHY: continued

CHAPTERS IN BOOKS: 2013 Aschner M, Farina M, Rocha JBT. Mercury Neurotoxicity. In: Encyclopedia of Metalloproteins. Uversky V, Kretsinger RH, Uversky VN, Permyakov EA, Eds-in-Chief, Pollard AM, Associate Ed, Springer Science+Business Media New York, ISBN: 978-1-4614-1532-9 (Print) 978-1-4614-1533-6 (Online) 2013; pp 1362-1366.

Martinez-Finley EJ, Chakraborty S, Aschner M. Manganese in Biological Systems. In: Encyclopedia of Metalloproteins. Uversky V, Kretsinger RH, Uversky VN, Permyakov EA, Eds-in-Chief, Pollard AM, Associate Ed, Springer Science+Business Media New York, ISBN: 978-1-4614-1532-9 (Print) 978-1- 4614-1533-6 (Online) 2013; pp 1297-1301.

Martinez-Finley EJ, Aschner M. Mechanisms of cellular detoxification from arsenic. Encyclopedia Metalloproteins. Uversky V, Kretsinger RH, Uversky VN, Permyakov EA, Eds-in-Chief, Pollard AM, Associate Ed, Springer Science+Business Media New York, ISBN: 978-1-4614-1532-9 (Print) 978-1- 4614-1533-6 (Online) 2013; pp 159-161.

Farina M, Rocha JBT, Aschner M. Redox Status in Mediating MeHg neurotoxicity. In: Current Topics in Neurotoxicity: Methylmercury and Neurotoxicity, Ceccatelli S, Aschner M, Eds. Springer Science, 2013; pp 101-126.

Avila DS, Puntel RL, Soares FA, Rocha JBT, Aschner M. Manganese in Neurodegeneration. In: Metals in Cells. Encyclopedia of Inorganic and Biorganic Chemistry. Culotta V, Scott RS, eds. Chichester, UK: John Wiley & Sons, Ltd, 2013: 335-347.

Philbert MA, Moser V, Richardson RJ, Aschner M. Toxic Responses of the Nervous System. In: Casarett and Doull's Toxicology: The Basic Science of Poisons, Cassarett LJ, Doull J, Klaassen CD, Eds. McGraw-Hill Medical Publication Division, New York, NY, 2013; ISBN 0071769234; PP 733-766.

2014 Ávila DS, Puntel RL, Folmer V, Rocha JBT, Marreilha dos Santos AP, Aschner M. Manganese Neurotoxicity. In: Handbook of Neurotoxicity, Dopamine Neurotoxicity and Parkinson’s Disease Section, RM Kostrzewa, Editor, JS Segura-Aguilar, Section Editor, Springer Science Publishing Company, ISBN 978-1-4614-5836-4_3, 2014; pp 843-864.

Caito SW, Costa LG, Rongzhu L, Aschner M. Acrylonitrile. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 33-35.

Martinez-Finley EJ, Costa LG, Finkelstein Y, Aschner M. Arsenic. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 272-274.

Ávila DS, Costa LG, Aschner M. Manganese. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 995-997.

Costa LG, Aschner M. Amphetamines. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 152.

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BIBLIOGRAPHY: continued

CHAPTERS IN BOOKS: Costa LG, Aschner M. Chickpea intoxication. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 773.

Costa LG, Aschner M. Domoic acid. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 1016-1017

Costa LG, Giordano G, Aschner M. Ethanol. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN; 2014: 978-0-12-385158-1; pp. 216-218.

Costa LG, Aschner M. Methanol. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 1116.

Costa LG, Aschner M. Neurotoxicology overview. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 550-551.

Costa LG, Aschner M. Organophosphates and carbamates. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 696-697.

Costa LG, Aschner M. Polybrominated diphenyl ethers. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 915-916.

Costa LG, Giordano G, Aschner M. Snake venoms. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 227.

Costa LG, Aschner M. Organic solvents. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 694-695.

Fretham S, Costa LG, Rocha JBT, Farina M, Aschner M. Mercury. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 1101-1103.

Finkelstein Y, Martinez-Finley EJ, Costa LG, Aschner M. Lead. Encyclopedia of the Neurological Sciences, Aminoff MJ, Daroff RB, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Neurotoxicology Section. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 848-852.

Chakraborty S, Martinez-Finley E, Caito S, Chen P, Aschner M. Manganese. In: Binding, Transport and Storage of Metal Ions in Biological Systems. W Maret, AG Wedd, eds. RSC Book on Metallo-Biology, Royal Society of Chemistry, Cambridge, 2014, ISBN: 978-1-84973-599-5; pp. 260-281.

(Revised 9/26/2017) 36 Michael Aschner Curriculum Vitae

CHAPTERS IN BOOKS: Fretham SJB, Aschner M. Mercury. In: Binding, Transport and Storage of Metal Ions in Biological Systems. W Maret, AG Wedd, eds. RSC Book on Metallo-Biology, Royal Society of Chemistry, Cambridge, 2014, ISBN: 978-1-84973-599-5; pp. 747-767.

Fretham SJB, Martinez-Finley EJ, Aschner M. Mercury and neurodegeneration. In: Bioactive Nutriceuticals and Supplements in Neurological and Brain Disease: Prevention and Therapy. Watson RR, Preedy V, eds. Elsevier, Oxford, UK; 2014; ISBN-10: 0124114628, pp 237-244

Lucchini RG, Aschner M, Kim Y, Šaric M. Manganese. Handbook on the Toxicology of Metals, 4th Edition. Friberg L, Nordberg GF, Vouk VB, Eds. Elsevier 2014; ISBN-10: 0444594531; pp. 995-1011.

Lucchini RG, Aschner M, Caito S. Neurotoxicology of Metals. Handbook on the Toxicology of Metals, 4th Edition. Friberg L, Nordberg GF, Vouk VB, Eds. Elsevier 2014; ISBN-10: 0444594531; pp. 299-311.

Fretham SJB, Caito S, Martinez-Finley EJ, Giordano G, Costa LG, Aschner M. Neurotoxicology. In: Hayes’ Principles and Methods of Toxicology, Sixth Edition Eds: 72 AW, Kruger CL; CRC Press, Boca Raton, FL, 2014, ISBN-13: 978-1842145364; pp. 1579-1600.

Costa LG, Aschner M. Toxicology of the Nervous System. In: Encyclopedia of Human Biology, Reference Module in Biomedical Sciences. Simon MI, Abelson J, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Toxicology Section. Elsevier, Oxford, UK; 2013; doi: 10.1016/B978-0-12-801238- 3.00206-3; pp. 1-9.

Caito S, Costa LG Aschner M. Toxicology of Metals. In: Encyclopedia of Human Biology,Reference Module in Biomedical Sciences. Simon MI, Abelson J, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Toxicology Section. Elsevier, Oxford, UK; 2014; 10.1016/B978-0-12-801238-3.00209-9; pp. 1-8.

Costa LG, Aschner M. Toxicology of Pesticides. In: Encyclopedia of Human Biology, Reference Module in Biomedical Sciences. Simon MI, Abelson J, Eds-in-Chief, Costa LG, Aschner M, Associate Eds, Toxicology Section. Elsevier, Oxford, UK; 2014; doi: 10.1016/B978-0-12-801238-3.00208-7, pp. 1-9.

Philbert MA, Aschner M. Glial Cells. In: Nervous System and Behavioral Toxicology. In: Reference Module in Biomedical Sciences, 2nd Edition, Caplan M, Ed. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12- 385158-1; pp. 199-219.

Aschner M, Toews A. Myelin. In: Nervous System and Behavioral Toxicology. In: Reference Module in Biomedical Sciences, 2nd Edition, Caplan M, Ed. Elsevier, Oxford, UK, 2014, ISBN: 978-0-12-385158-1; pp. 181-198.

2015 Sidoryk-Wegrzynowicz M, Aschner M. Manganese and the glutamine/glutamate-γ-aminobutyric acid cycle. In: Glutamine in Clinical Nutrition. Rajendram R, Preedy VR, Patel VB, eds. Springer Science and Business Media, New York, NY, 2015; pp. 401-413.

Jiang GCT, Aschner M. Depleted Uranium. In: Handbook of the Toxicology of Chemical Warfare Agents, Gupta R, Ed. San Diego, CA: Elsevier Academic Press, 2015; ISBN 978-0-12-374484-5; pp. 447-460.

Martinez-Finley EJ, Caito S, Fretham S, Chen P, Aschner M. Metal Toxicity. In Mammalian Toxicology, ed. M Abou-Donia, John Wiley and Sons, Hoboken, NJ, 2015; ISBN 1119940419pp 171-175.

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BIBLIOGRAPHY: continued

CHAPTERS IN BOOKS: Caito S, Aschner M. Neurotoxicity of Metals. In Handbook of Clinical Neurology. Series Editors, Aminoff MJ, Boller F, Swaab DF. Occupational Neurology, vol 131, Lotti M, Bleeker ML, Eds. Elsevier, Oxford, UK, 2015. ISBN :9780444626271, pp. 169-189.

Wormser U, Finkelstein Y, Proscura E, Brodsky B, Aschner M. Chemical Warfare Agents. In: Experimental Toxicology and Pharmacology, Roberts SM, Klotz L-C, Kehrer JP, Eds. Springer Science, London, UK. 2015; pp. 369-379.

Karki P, Smith K, Aschner M, Lee E. Mechanism of manganese-induced impairment of astrocytic glutamate transporters. In: Manganese in Health and Disease. L Costa, M Aschner, eds. Royal Society of Chemistry, Cambridge, UK, 2015, pp; 258-278.

Avila DS, Farina M, Rocha JBT, Aschner M. Manganese and oxidative stress. In: Manganese in Health and Disease. L Costa, M Aschner, eds. Royal Society of Chemistry, Cambridge, UK, 2015; pp. 199- 220.

Avila DS, Gubert P, Roos DH, Puntel R, Aschner M. Manganese, Chapter 441. In: Encyclopedia of Food and Health, B Caballero, P Finglas, F Toldra, Eds-in-Chief. Elsevier, Oxford, UK, 2015. ISBN 9780123849472.

Costa LG, Aschner M. Environmental Factors in Neurodevelopmental Disorders: Summary and Perspectives. Chapter 9. In: Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. Eds. LG Costa, Aschner M, Elsevier Academic Press, 2015; pp. 193-194.

Aschner M, Costa LG. Environmental Factors in Neurodegenerative Disorders: Summary and Perspectives. Chapter 20. In: Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. Eds. LG Costa, Aschner M, Elsevier Academic Press, 2015; pp. 423-424.

2016 Kall J, Aschner M. Just A. Dental Amalgam, Mercury Exposure, and Human Health Risks Throughout the Lifespan. In: Epigenetics, the Environment, and Children's Health across Lifespans. Hollar D, Ed, Springer Publishing, Switzerland, 2016; pp 159-196.

Peres TV, Aschner M. Nutritional, genetic and molecular aspects of manganese intoxication. Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Collins JF, Ed. Elsevier, Oxford, UK pp. 367-376.

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BIBLIOGRAPHY: Continued -Number of Citations: >19,000; h-index: 67

JOURNAL ARTICLES: ASCHNER M - PUBMED RESULTS (CTRL + CLICK TO THE LEFT TO FOLLOW LINK) 1984 Sager PR, Aschner M, Rodier PM. Persistent differential alterations in developing cerebellar cortex of male and female mice after methylmercury exposure. Develop Brain Res 1984; 12:1-11.

Rodier PM, Aschner M, Sager PR. Mitotic arrest in the developing CNS after prenatal exposure to methylmercury. Neurobehav Toxicol Teratol 1984; 6:379-385.

1986 Rodier PM, Aschner M, Lewis LS, Koeter HBWM. Mitotic activity in developing brain after exposure to inhalant anesthetics. Anesthesiology 1986; 64; 680-687.

Aschner M, Rodier PM, Finkelstein JN. Reduction of axonal transport in the rat optic system after direct application of methylmercury. Brain Res 1986; 381; 244-250.

Aschner M. Changes in axonally transported proteins in the rat CNS visual system following systemic methylmercury exposure. Acta Pharmacol Toxicol 1986; 59:151-157.

Aschner M. Effects of systemic consumption of methylmercury-adulterated water on fast axonal transport in the rat visual system. Acta Pharmacol Toxicol 1986; 59:349-355.

1987 Aschner M, Rodier PM, Finkelstein JN. Increased axonal transport in the rat optic system after systemic exposure to methylmercury: Differential effects in local vs. systemic exposur Anticholinesterase Pesticides: Metabolism e conditions. Brain Res 1987; 401:132-141.

Aschner M. Changes in axonally transported proteins in the mature and developing rat nervous system during early stages of methylmercury exposure. Pharmacol Toxicol 1987; 60:81-85.

Aschner M, Clarkson TW. Mercury 203 distribution in pregnant and non-pregnant rats following systemic infusions with thiol containing amino acids. Teratology 1987; 36:321-328.

1988 Aschner M, Clarkson TW. Distribution of 203 mercury in pregnant dams and their fetuses following systemic infusions with thiol-containing amino acids and glutathione, during late gestation. Teratology 1988; 38:145-155.

Aschner M, Clarkson TW. Amino acid carrier-mediated uptake of methylmercury across the blood- brain barrier. Brain Res 1988; 462:31-39.

Aschner M, Clarkson TW. Methylmercury uptake across bovine brain capillary endothelial cells in vitro: The role of amino acids. Pharmacol Toxicol 1988; 64:293-297.

1989 Aschner M. Brain, kidney and liver [203Hg]-methylmercury uptake in the in vivo rat: Relationship to the neutral amino acid carrier. Pharmacol Toxicol 1989; 65:17-20.

Aschner M, Aschner JL. Mucocutaneous lymph node syndrome: Is there a relationship to mercury exposure? Am J Dis Child 1989; 143:1133-1134.

1990 Aschner M, Eberle N, Goderie S, Kimelberg HK. Methylmercury uptake in rat primary astrocyte cultures: the role of the neutral amino acid transport system. Brain Res 1990; 521:221-228.

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BIBLIOGRAPHY: continued

JOURNAL ARTICLES Aschner M, Aschner JL. Mercury neurotoxicity: Mechanisms of blood-brain barrier transport. Neurosci Biobehav Rev 1990; 14:169-176.

Aschner JL, Lennon JM, Fenton JW II, Aschner M, Malik AB. Enzymatic activity is necessary for thrombin-mediated increase in endothelial permeability. Am J Physiol 1990; 259: L270-L275.

Aschner M, Eberle N, Miller K, Kimelberg HK. Interaction of methylmercury with rat primary astrocyte cultures: effects on rubidium uptake and efflux and induction of swelling. Brain Res 1990; 530:245-250.

Aschner JL, Lennon JM, Fenton JW II, Aschner M, Malik AB. Enzymatic activity is necessary for thrombin-mediated increase in endothelial permeability. Am J Physiol 1990; 259: L270-L275.

Aschner M, Eberle N, Miller K, Kimelberg HK. Interaction of methylmercury with rat primary astrocyte cultures: effects on rubidium uptake and efflux and induction of swelling. Brain Res 1990; 530:245-250.

Aschner M, Aschner JL. Manganese uptake across the blood-brain barrier: Relationship to iron homeostasis. Brain Res Bull 1990; 24:857-860.

Aschner M, Aschner JL. Manganese uptake across the blood-brain barrier. In “Highlights from the Literature”. Cerebrovascul Brain Metab Rev 1990; 2:373.

1991 Aschner M, Chen R, Kimelberg HK. Effects of mercury and lead on rubidium uptake and efflux in cultured rat astrocytes. Brain Res Bull 1991; 26:639-642.

Aschner M, Kimelberg HK. The use of astrocytes in culture as model systems for evaluating neurotoxic- induced-injury. Neurotoxicology 1991; 12:505-518.

Aschner M, Eberle N, Kimelberg HK. Interaction of methylmercury with rat primary astrocyte cultures: methylmercury efflux. Brain Res 1991; 554:10-14.

Aschner M. The transport of manganese across the blood-brain barrier. In: Summary of Workshop Discussions at the Manganese and Methylcyclopentadienyl Manganese Tricarbonyl (MMT) Conference, Office of Research and Development, US, Environmental Protection Agency, Appendix B, 1-4, 1991.

Aschner M, Aschner JL. Manganese neurotoxicity: Cellular effects and blood-brain barrier transport mechanisms. Neurosci Biobehav Rev 1991; 15:333-340.

1992 Aschner M, Gannon M, Kimelberg HK. Manganese (Mn) uptake and efflux in cultured rat astrocytes. J Neurochem 1992; 58:730-735.

Aschner M, Gannon M, Kimelberg HK. Interaction of trimethyl tin with rat primary astrocyte cultures: Effects on rubidium, glutamate, and aspartate uptake and efflux. Brain Res 1992; 582:181-185.

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BIBLIOGRAPHY: continued

JOURNAL ARTICLES Aschner M, Aschner JL. Cellular and molecular effects of trimethyltin and triethyltin: Relevance to organotin neurotoxicity. Neurosci Biobehav Rev 1992; 16:427-435.

1993 Aschner M, LoPachin RM Jr. Astrocytes: A link to chemically induced CNS injury. J Toxicol Environ Health 1993; 38:329-341.

Aschner M, Du Y-L, Gannon M, Kimelberg HK. Furosemide treatment reverses methylmercury-induced increases in excitatory amino acid efflux from rat primary astrocyte cultures. Brain Res 1993; 602:181- 186.

LoPachin R, Aschner M. Glial-neuronal interactions: the relevance to neurotoxic mechanisms. Toxicol Appl Pharmacol 1993; 118:141-158.

Albrecht J, Talbot M, Kimelberg HK, Aschner M. The role of sulfhydryl groups and calcium in the mercuric chloride-induced inhibition of glutamate uptake in rat primary astrocyte cultures. Brain Res 1993; 607:249-254.

Dave V, Vitarella D, Aschner JL, Fletcher P, Kimelberg HK, Aschner M. Lead increases inositol (1,4,5)trisphosphate levels but does not interfere with calcium-transient in primary rat astrocytes. Brain Res 1993; 618:9-18.

Mullaney KJ, Vitarella D, Albrecht J, Kimelberg HK, Aschner M. Stimulation of D-aspartate efflux by mercuric chloride from rat primary astrocyte cultures. Dev Brain Res 1993; 75:261-268.

Aschner M. Effects of heavy metals on astrocytic homeostasis: Correlation with -SH modifying reagents. Acta Neurobiol Exp 1993; 53:581-599.

Aschner M. Letter to the Editor. The lead controversy, Pediatrics 1993; 92:509.

1994 Aschner M. Letter to the Editor. Bilirubin and other brain cells, Pediatrics 1994; 93:155-156.

Aschner M, Gannon. M. Manganese (Mn) transport across the blood-brain barrier: Saturable and transferrin-dependent transport mechanisms. Brain Res Bull 1994; 33:345-349.

Mullaney KJ, Fehm MN, Vitarella D, Wagoner DE Jr. Aschner M. The role of -SH groups in methylmercuric chloride-induced D-aspartate and rubidium release from rat primary astrocyte cultures. Brain Res 1994; 641:1-9.

Aschner M, Mullaney KJ, Fehm MN, Vitarella D, Wagoner DE Jr, Kimelberg HK. The role of sulfhydryl groups in D-aspartate and rubidium release from neonatal rat primary astrocyte cultures. Brain Res 1994; 648:16-23.

Vitarella D, DiRisio D, Kimelberg HK, Aschner M. Potassium and taurine release are highly correlated with regulatory volume decrease in neonatal primary rat astrocyte cultures. J Neurochem 1994; 63:1143-1149.

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BIBLIOGRAPHY: continued

JOURNAL ARTICLES: Dave V, Mullaney KJ, Goderie S, Kimelberg HK, Aschner M. Astrocytes as mediators of methylmercury (MeHg) neurotoxicity: Effects on D-aspartate and serotonin (5-HT) uptake. Develop Neurosci 1994; 16:222-231.

Aschner M, Mullaney KJ, Wagoner D, Lash LH, Kimelberg HK. Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures. Brain Res 1994; 664:133-140.

1995 Aschner M, Mullaney KJ, Fehm MN, Wagoner DE Jr, Vitarella D. Astrocytes as potential modulators of mercuric chloride neurotoxicity. Cell Mol Neurobiol 1995; 16:637-652.

Rising L, Vitarella D, Kimelberg HK, Aschner M. Cadmium chloride (CdCl2)-induced metallothionein (MT) expression in neonatal rat primary astrocyte cultures. Brain Res 1995; 678:91-98.

Aschner M, Mullaney KJ, Wagoner D, Lash LH, Kimelberg HK. Adenosine modulates methylmercuric chloride (MeHgCl)-induced D-aspartate release from neonatal rat primary astrocyte cultures. Brain Res 1995; 689:1-8.

Rising L, Vitarella D, Kimelberg HK, Aschner M. Metallothionein induction in neonatal rat primary astrocyte cultures protects against methylmercury cytotoxicity. J Neurochem 1995; 65:1562-1568.

1996 Aschner M. Methylmercury in astrocytes - what possible significance? Neurotoxicology 1996; 17:93- 106.

Aschner M, Rising L, Vitarella D, Mullaney KJ. Differential sensitivity of neonatal rat astrocyte cultures to mercuric chloride (MC) and methylmercury (MeHg): Studies on K+ and amino acid transport, and metallothionein (MT) induction. Neurotoxicology 1996; 17:107-116.

Vitarella D, Kimelberg HK, Aschner M. Regulatory volume decrease in primary astrocyte cultures: Relevance to methylmercury neurotoxicity. Neurotoxicology 1996; 17:117-123.

Conklin DR, Cowan KS, Aschner M. Detection of metallothionein (MT) proteins with radiolabeled [14C]- iodoacetamide. Toxicol Methods 1996; 6:149-155.

Aschner M. The functional significance of brain metallothioneins, FASEB J.1996; 10:1129-1136.

Cowan KS, Conklin DR, Aschner M. Metallothionein induction by bismuth in neonatal rat primary astrocyte cultures. Brain Res 1996; 732:106-112.

Vitarella D, Kimelberg HK, Aschner M. Inhibition of regulatory volume decrease (RVD) in swollen rat primary astrocyte cultures by methylmercury is due to increased amiloride-sensitive Na+ uptake. Brain Res 1996; 732:169-178.

Vitarella D, Conklin DR, Kimelberg HK, Aschner M. Metallothionein (MT) induction protects swollen rat primary astrocyte cultures from methylmercury-induced inhibition of regulatory volume decrease. Brain Res 1996; 738:213-221.

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BIBLIOGRAPHY: continued

JOURNAL ARTICLES: Aschner M. Astrocytes as modulators of mercury-induced neurotoxicity. Neurotoxicology 1996; 17:663- 670.

1997 Aschner M, Cherian MG, Klaassen CD, Palmiter RD, Erickson JC, Bush AI. Metallothioneins in brain: their role in physiology and pathology. Toxicol Appl Pharmacol 1997; 142:229-242.

Aschner M. Astrocyte metallothioneins (MTs) and their neuroprotective role. Ann NY Acad Sci 1997; 825:603-627.

Aschner M, Conklin DR, Aschner JL. Induction of metallothionein-I (MT-I) mRNA in primary astrocyte cultures is mediated by hypotonicity and not ethanol (EtOH) per se. Brain Res 1997; 770:289-293.

1998 Aschner M. Astrocytic functions and physiological reactions to injury: The potential to induce and/or exacerbate neuronal dysfunction. An invited Forum Position Paper, Neurotoxicology 1998; 19:7-18.

Aschner M. Response to commentaries on invited Forum Position Paper: Astrocytic functions and physiological reactions to injury: The potential to induce and/or exacerbate neuronal dysfunction? Neurotoxicology 1998; 19:37-38.

Aschner M, Lorscheider FL, Cowan KS, Conklin DR, Vimy JM, Lash L. Metallothionein (MT) induction in rat brain and primary astrocyte cultures by in utero exposure to elemental mercury vapor (Hg0). Brain Res 1998; 778:221-231.

Aschner M. Astrocytes as mediators of immune and inflammatory responses in the CNS. Neurotoxicology 1998; 19:269-282.

Aschner M, Stark S, Vrana KE, Conklin DR. Acidosis-induced metallothionein (MT) mRNA expression in neonatal rat primary astrocyte cultures. Neurotoxicology 1998; 19:227-236.

Rutledge EM, Aschner M, Kimelberg HK. Pharmacological characterization of swelling induced [3H]-D-aspartate release from primary astrocyte cultures. Am J Physiol 1998; 274:C1511-C1520.

Hutson SM, Berkich D, Drown P, Xu B, Aschner M, LaNoue KF. Role of branched chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism. J Neurochem 1998; 71:863-874.

Verity MA, Aschner M. Mechanisms of the toxic action of manganese: animal models. Neurotoxicology 1998; 19:483-485.

Conklin DR, Tan KH, Aschner M. Dimethyl sulfoxide, but not acidosis-induced metallothionein mRNA expression in neonatal rat primary astrocyte cultures is inhibited by the bioflavonoid, quercetin. Brain Res 1998; 794:304-308.

Aschner M, Vitarella D, Allen JW, Conklin DR, Cowan KS. Methylmercury-induced astrocytic swelling is associated with activation of the Na+/H+ antiporter, and is fully reversed by amiloride. Brain Res 1998; 799:207-214.

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BIBLIOGRAPHY: continued

JOURNAL ARTICLES: Aschner M. Metallothionein (MT) isoforms in the central nervous system (CNS): Regional and cell- specific distribution, and potential functions as an antioxidant Neurotoxicology 1998; 19:653-660.

Aschner M, Vitarella D, Allen JW, Conklin DR, Cowan KS. Methylmercury-induced inhibition of regulatory volume decrease in astrocytes: Characterization of osmoregulator efflux and its reversal by amiloride. Brain Res, 1998; 811:133-142.

Aschner M, Conklin DR, Yao CP, Allen JW, Tan KH. Induction of astrocyte metallothioneins (MTs) by zinc confers resistance against the acute cytotoxic effects of methylmercury on cell swelling, Na+ uptake, and K+ release. Brain Res 1998; 813:254-261.

Aschner M, Conklin DR. Induction of metallothionein-I (MT-I) mRNA in primary astrocyte cultures is mediated by hypotonicity. In: Proceedings of the 4th International Metallothionein Meeting, Kansas City, MO. Birkhåuser Verlag, AG, Basel, Switzerland, 1998, 383-387.

Aschner M. Immune and inflammatory responses in the CNS: Modulation by astrocytes. Toxicol Lett 1998; 102-103:283-287.

1999 Silbergeld EK, Davis JM, Aschner M, Aposhian HV, Mergler D. Should manganese be added to gasoline: Making rationale public policy in the face of uncertainty. J Environ Res 1999; 80:105-109.

Aschner M, Allen JW, Kimelberg HK, LoPachin RM, Streit JW. Glial Cells in Neurotoxicity Development. Annual Rev Pharmacol Toxicol 1999; 39:151-173.

Yao CP, Allen JW, Conklin DR, Aschner M. Transfection and overexpression of metallothionein-I in neonatal rat primary astrocyte cultures and in astrocytoma cells increases their resistance to methylmercury-induced cytotoxicity. Brain Res 1999; 818:414-420.

Aschner M. Response to forum position paper by HK Kimelberg: Current methods and approaches to studying astrocytes. Neurotoxicology 1999; 20:719-722.

Zheng W, Zhao Q, Slavkovich V, Aschner M, Graziano JH. Alteration in iron homeostasis following chronic exposure to manganese in rats. Brain Res 1999; 833:125-132.

Aschner M, Vrana KE, Zheng W. Manganese uptake and distribution in the central nervous system (CNS). Neurotoxicology 1999; 20:173-180.

Yao CP, Allen JW, Aschner M. Metallothioneins attenuate methylmercury-induced neurotoxicity in cultured astrocytes and astrocytoma cells. Ann NY Acad Sci 1999; 890:223-226.

2000 Aschner M. Interactions between pesticides and glia; an unexplored experimental field. Neurotoxicology 2000; 21:175-180.

Yao CP, Allen JW, Mutkus LA, Xu SB, Tan KH, Aschner M. Foreign metallothionein-I (MT-I) expression by transient transfection in MT-I and –II null astrocytes confers increased protection against acute methylmercury cytotoxicity. Brain Res 2000; 855:32-38.

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JOURNAL ARTICLES: Stokes AH, Lewis DY, Lash LH, Jerome WG, III, Grant KW, Aschner M, Vrana KE. Dopamine toxicity in neuroblastoma cells: Role of glutathione and apoptosis. Brain Res 2000; 858:1-8.

Aschner M, Yao CP, Allen JW, Tan KH. Methylmercury alters glutamate transport in astrocytes. Neurochem Int 2000; 37:199-206.

Aschner M, Allen JW. Astrocytes in methylmercury, ammonia, methionine sulfoximine, and alcohol induced neurotoxicity. Neurotoxicology 2000; 21:573-580.

Aschner M. Manganese: Brain transport and emerging research needs. Environ Health Persp 2000; 108:429-432.

Aschner M. Astrocytic swelling, phospholipase A2, glutathione, and glutamate: interactions in methylmercury-induced neurotoxicity. Cell Mol Biol 2000; 46:843-854.

Aschner M. Possible mechanisms of methylmercury cytotoxicity. Mol Biol Today 2000; 1:43-48 (Online article @ http://www.molbio.net.

Aschner M. Electrical resistance method for measuring volume changes in astrocytes as an in vitro screening method for neurotoxicity. Pharma-Transfer, Dialogue in Drug Discovery. 2000; On line article, http://www.pharma-transfer.com

Aschner M, Costa LG. Mechanisms of developmental neurotoxicology: Molecular and cellular targets. Neurotoxicology 2000; 21:266-268.

Aschner M, DesForges C. Brain function: what can go awry and why? In: Newsletter, OEHS, International Manganese Institute, Jan. 2000; 2-4.

Aschner M. Letter to the Editor, response to Inventing the Future. U.S. News and World Report February 28, 2000; page 9.

Aschner, M. Letter to the Editor, Mercury, infant neurodevelopment, and vaccination. J Pediat 2000; 138:450-451.

2001 Aschner M. Neuron-astrocyte interactions: implications for cellular energetics and antioxidant levels. Neurotoxicology 2001; 21:1101-1108.

Allen JW, Shanker G, Aschner M. Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes but not in neurons. Brain Res 2001; 891:148-157.

Allen JW, Shanker G, Aschner M. Mercuric chloride, but not methylmercury inhibit glutamine synthetase activity in primary cultures of cortical astrocytes. Brain Res 2001; 894:131-140.

Aschner M, Mutkus LA, Allen JW. Amino acid uptake and release in primary astrocyte cultures exposed to ethanol. Ann NY Acad Sci 2001; 939:23-27.

Aschner M, Allen JW, Mutkus LA, Cao C-C. Ethanol-induced swelling in neonatal rat primary astrocyte cultures. Brain Res 2001; 900:219-226.

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JOURNAL ARTICLES: Allen JW, Mutkus LA, Aschner M. Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase. Brain Res 2001; 902:92-100.

Aschner M, Mutkus LA, Allen JW. Aspartate and glutamate transport in acutely and chronically ethanol exposed neonatal rat primary astrocyte cultures. Neurotoxicology 2001; 22:601-605.

Shanker G, Allen JW, Mutkus LA, Aschner M. The uptake of cysteine in cultured primary astrocytes and neurons. Brain Res 2001; 902:156-163.

Allen JW, El-Oqayli H, Aschner M, Syversen T, Sonnewald U. Methylmercury has a selective effect on mitochondria in cultured astrocytes in the presence of [U-13C]glutamate. Brain Res 2001; 908:149-154.

dos Santos AP, Batoréu MC, Aschner M. Report on the eighth meeting of the International Neurotoxicology Association. Neurotoxicology 2001; 22:503-504.

Shanker G, Allen JW, Mutkus LA, Aschner M. Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons. Brain Res 2001; 914:159-165.

Hidalgo H, Aschner M, Zatta P, Vasak M. Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull 2001; 55:133-145.

Tiffany-Castiglioni E, Guerri C, Aschner M, Matsushima GK, O’Callaghan JP, Streit WJ. Roles of glia in developmental neurotoxicity: Session VI Summary and Research Needs. Neurotoxicology 2001; 567- 573.

Shanker G, Aschner M. Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: Evidence for methylmercury-targeted disruption of astrocyte transport. J Neurosci Res 2001; 66:998-1002.

Yang J, Mutkus LA, Strandhoy, JW, Sumner D, Stevens JT, Eldridge JC, Aschner M. Transendothelial permeability of chlorpyrifos in RBE4 monolayers is modulated by astrocyte-conditioned medium. Mol Brain Res 2001; 97:43-50.

Seegal RF, Aschner M. Session IX – Summary and research needs: Selected presentations and general discussion, XIX International Neurotoxicology Conference. Neurotoxicology 2001; 22:849-852

2002 Aschner M. Open issues from the 15th international conference on manganese. Neurotoxicology 2002; 23:123-125.

Sonnewald U, Qu H, Aschner M. Pharmacology/toxicology of astrocyte/neuron glutamate cycling. J Pharmacol Exp Therapeut 2002; 301:1-6

Aschner M. Functionally impoverished astrocytes as triggers for chemical-induced neurodegeneration: mechanistic considerations. Comments Toxicol. 2002; 8:1-8.

Aschner M. Neurotoxic mechanisms of fish-borne methylmercury. J Environ Toxicol Pharmacol 2002; 12:101-104.

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BIBLIOGRAPHY: continued

JOURNAL ARTICLES: Aschner M, Walker SJ. The neuropathogenesis of mercury toxicity. Mol Psych 2002; 7:S40-S41.

Allen JW, Shanker G, Tan KH, Aschner M. The consequences of methylmercury exposure on interactive functions between astrocytes and neurons. Neurotoxicology 2002; 23:755-760.

Worley CG, Bombick D, Allen JW, Suber RL, Aschner M. Effects of manganese on oxidative-stress in CATH.a cells. Neurotoxicology 2002; 23:159-164.

Erikson K, Aschner M. Manganese causes differential regulation of glutamate transporter (GLAST), taurine transporter, and metallothionein in cultured rat astrocytes. Neurotoxicology 2002; 23:595-602.

Aschner M, Shanker G, Erikson K, Yang J, Mutkus LA. The uptake of manganese in brain endothelial cultures. Neurotoxicology 2002; 23:165-168.

Weber S, Dorman DC, Lash LH, Erikson K, Aschner M. Effects of manganese on the developing rat brain: oxidative-stress related endpoints. Neurotoxicology 2002; 23:169-175.

Erikson K, Shihabi ZK, Aschner, JL, Aschner M. Manganese accumulates in iron deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations. Biol Trace Element Res 2002; 87:143-156

Gunter KK, Miller LM, Aschner M, Eliseev R, Depuis D, Gavin CE, Gunter TE. XANES spectroscopy: A promising tool for toxicology: A tutorial. Neurotoxicology 2002; 23:127-146.

Aschner M, Sonnewald U, Tan KH. Astrocyte modulation of neuropathologic damage. Brain Pathol 2002; 12:476-481.

Erikson K, Suber RL, Aschner M. Glutamate/aspartate transporter (GLAST), taurine transporter, and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate. Neurotoxicology 2002; 23:281-288.

Allen JW, Mutkus LA, Aschner M. Chronic ethanol increases taurine transport and efflux in cultured astrocytes. Neurotoxicology 2002; 23:693-700.

Shanker G, Mutkus LA, Walker S, Aschner M. Methylmercury enhances arachidonic acid release and cytosolic phospholipase A2 expression in primary cultures of neonatal astrocytes. Mol Brain Res 2002; 106:1-11.

2003 Shanker, G, Aschner M. Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants. Mol Brain Res 2003; 110:85-91.

Aschner M. Manganese transport and speciation in the central nervous system (CNS) In: Oxidative Injury and CNS Toxicity. ISSN, 2003; 22:22-23.

Dobson AW, Weber S, Dorman DC, Lash LH, Erikson KM, Aschner M. Oxidative stress is induced in the rat brain following repeated inhalation exposure to manganese sulfate. Biol Trace Element Res 2003; 93:113-126.

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BIBLIOGRAPHY: continued

JOURNAL ARTICLES Nelson L et al. (Aschner M). Response Letter to Neilson EG, the role of medical school admissions committees in the decline of physician-scientists. J Clin Invest. 2003; 111:765-7. e-letter.

Erikson KM, Aschner M. Manganese Neurotoxicity and Glutamate Metabolism. Neurochem Int 2003; 43:475-80.

Vrana KE, Freeman WM, Aschner M. Use of microarray in toxicology research. Neurotoxicology 2003; 24:321-332.

Stredrick DL, Jiang GC-T, Suber L, Mockus S, Aschner M, Vrana KE. Manganese-mediated inhibition of tyrosine hydroxylase in CATH.a cells. Mol Brain Res 2003.

Yang J, Aschner M. Developmental aspects of blood-brain barrier (BBB) and rat brain endothelial (RBE4) cells as in vitro model for studies on chlorpyrifos transport. Neurotoxicology 2003; 24:741-746.

Qu H, Syversen T, Aschner M, Sonnewald U. Effect of methylmercury on glutamate metabolism in cerebellar astrocytes in culture. Neurochem Int 2003; 43:411-416.

Aschner M. Letter to the Editor, Roots of the Problem. The Scientist 2003; 17:15.

Aschner, Cao C-C, Wu Q, Friedman MA. The acute effects of acrylamide on astrocyte functions. Ann NY Acad Sci 2003; 993:296-304.

Aschner M, Aschner Y, Sonnewald U. The Neuron-Glia Unit in Neuropathology: Is it a Double-Edged Sword? Jap J Cereb Blood Flow Metab 2003; 15:95-100.

Zheng W, Aschner M, Ghersi-Egea J-F. Brain barrier systems contributions to metal-induced neurotoxicities. Toxicol Appl Pharmacol 2003; 192:1-11.

Shanker G, Syversen T, Aschner M. Astrocyte-mediated methylmercury neurotoxicity. Biol Trace Element Res 2003; 95:1-10.

Youdim M, Slikker W, Bowyer J, Banik N, Marini A., Scallet A, Virmani A., Aschner M. Questions and answers - Session VII: Oxidative stress, mitochondria, and approaches to neuroprotection. Ann NY Acad Sci 2003; 993:345-349.

2004 Costa LG, Aschner M, Vitalone A, Syversen T, Soldin OP. Developmental Neurotoxicity. Ann Rev Pharmacol Toxicol 2004; 44:87-110.

Shanker G, Hampson RE, Aschner M. Methylmercury stimulates arachidonic acid release and cytosolic phospholipase A2 expression in primary neuronal cultures. Neurotoxicology 2004; 25:399-406.

Erikson KM, Dobson AW, Dorman DC, Aschner M. Does manganese induce oxidative stress in the rat brain? Sci Total Environ 2004; 334-335:409-416.

Erikson KM, Dorman DC, Lash LH, Dobson, AW, Aschner M. Airborne manganese exposure differentially affects endpoints of oxidative stress in an age and sex-dependent manner. Biol Trace Element Res 2004; 100:49-62.

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JOURNAL ARTICLES Stredrick DL, Stokes AH, Worst TJ, Freeman WM, Johnson EA, Lash LH, Aschner M, Vrana KE. Manganese-induced cytotoxicity in dopamine-producing cells. Neurotoxicology 2004; 25:543-553

Dobson AW, Erikson KM, Aschner M. Manganese neurotoxicity. Ann New York Acad Sci 2004; 1012:115-128.

Erikson KM, Syversen T, Steinnes E, Aschner M. Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency. J Nutrit Biochem 2004; 15:335-341.

Aschner M, Syversen T. Neurotoxicology: Principles and considerations of in vitro assessment. Alt Lab Animal 2004; 32:323-327.

Aschner M. Book Review, Metal Ions and Neurodegenerative Disorders, edited by Paolo Zatta, World Scientific Publishing Company. Pte. Ltd., 2003. 511 pp. ISBN 981-238-398-0. Biol Trace Element Res 2004.

Aschner M. Book Review, Glutamate Receptors and Peripheral Tissue: Excitatory Transmission Outside the CNS, edited by Santokh Gill and Olga Pulido, Kluwer Academic / Plenum Publishers, NY, June 2004, ISBN 0-306-47973-7.

Shanker G, Aschner JL, Syversen T, Aschner M. Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury. Mol Brain Res 2004; 128:48-57.

2005 Aschner M, Erikson KM, Dorman DC. Manganese dosimetry: species differences and implications for neurotoxicity. Crit Rev Toxicol 2005; 35:1-32.

Erikson KM, Syversen T, Aschner J, Aschner M. Interactions between excessive manganese exposures and dietary iron-deficiency in neurodegeneration. J Environ Toxicol Pharmacol 2005; 19:415–421.

Erikson KM, Dorman DC, Lash LH, Aschner M. Persistent alterations in biomarkers of oxidative stress due to combined in utero and neonatal manganese inhalation. Biol Trace Element Res 2005; 2:151- 164.

Aschner M, Syversen T. Methylmercury: recent advances in the understanding of its neurotoxicity. Therapeutic Drug Monitoring 2005; 27:278-283.

Fitsanakis VA, Aschner M. The role of amino acids in metal neurotoxicity. Toxicol Appl Pharmacol 2005; 204:343-354.

Shanker G, Syversen T, Aschner JL, Aschner M. Modulatory effect of glutathione status and antioxidants on methylmercury induced free radical formation in primary cultures of cerebral astrocytes. Mol Brain Res 2005; 137: 11-22.

Gunter KK, Aschner M, Miller LM, Eliseev R, Salter J, Anderson K, Hammond S, Gunter TE. Determination of the oxidation states of manganese in PC12 and NGF-induced PC12 cells. Free Radical Biol Med 2005; 39:164-81.

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BIBLIOGRAPHY: continued

JOURNAL ARTICLES Fitsanakis VA, Piccola G, Aschner JL, Aschner M. Manganese (Mn) transport in rat brain endothelial cell (RBE4) monolayers cultured in the presence of astrocyte conditioned media (ACM) is an active process. J Neurosci Res 2005; 81:235-243.

Mutkus LA, Aschner JL, Syversen T, Shanker G, Sonnewald U, Aschner M. The in vitro uptake of glutamate in GLAST and GLT-1 transfected mutant CHO-K1 cells is inhibited by the ethylmercury- containing preservative, thimerosal. Biol Trace Element Res 2005; 105:71-86.

Morken TS, Sonnewald U, Aschner M, Syversen T. Effects of methylmercury on primary brain cells in mono and co-culture. Toxicol Sci 2005; 87:169-175.

Aschner M, Aschner JL. Nutritional aspects of manganese neurotoxicity. Trace Elements, Oxidant Stress, and Human Health. Mol Asp Med 2005; 26:353-362.

Mutkus LA, Aschner JL, Fitsanakis VA, Aschner M. The in vitro uptake of glutamate in GLAST and GLT-1 transfected mutant CHO-K1 cells is inhibited by manganese. Biol Trace Element Res 2005; 107:221-230.

Mutkus LA, Aschner JL, Syversen T, Aschner M. Methylmercury alters the in vitro uptake of glutamate in GLAST and GLT-1 transfected mutant CHO-K1 cells. Biol Trace Element Res 2005; 107: 231-246.

Wu Q, Sidoryk M, Mutkus LA, Zielińska M, Albrecht J, Aschner M. Acrylamide stimulates glutamine uptake in Fischer 344 rat astrocytes by a mechanism involving upregulation of the amino acid transport system N. Ann NY Acad Sci 2005; 1053:435-443.

Aschner M, Wu Q, Friedman M. Effects of acrylamide on primary neonatal rat astrocyte functions. Ann NY Acad Sci 2005; 1053:444-454.

Erikson KM, John CE, Jones SR, Aschner, M. Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter. Environ Toxicol Pharmacol 2005; 20:390-394.

Aschner M, West A. Metallothioneins: brain structural attributes, inducibility and their role in neurodegeneration. J Alzheimer’s Dis 2005; 8:139-145.

Sharma H, Banik N., Mocchetti I, Aschner M, Kuan, CX, Maynard K Questions and answers: Session IX: Sensitive targets for neurotoxicity and neuroprotection Ann NY Acad Sci 2005; 1053:457-459.

2006 Aschner M. Editorial, Manganese in the shower: mere speculation over an invalidated public health danger. Med Hypoth 2006; 66:200-201.

Donahue AN, Aschner M, Lash LH, Syversen T, Sonntag W. Growth hormone administration to aged animals reduces glutathione disulfide levels in hippocampus. Mechanism Ageing Develop 2006; 127:57-63.

Mutkus LA, Aschner JL, Syversen T, Shanker G, Sonnewald U, Aschner M. Mercuric chloride (HgCl2) inhibits the in vitro uptake of glutamate in GLAST and GLT-1 transfected mutant CHO-K1 cells. Biol Trace Element Res 2006; 109:267-280.

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JOURNAL ARTICLES Fitsanakis VA, Piccola G, Aschner JL, Aschner M. Characteristics of Mn transport in rat brain endothelial (RBE4) cells, a model of the blood-brain barrier. Neurotoxicology 2006; 27:60-70.

Erikson KM, Aschner M. Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter. Neurotoxicology 2006; 27:125-130.

Milatovic D, Gupta RC, Aschner M. Anticholinesterase toxicity and oxidative stress. Sci World J 2006; 6:295-310.

Fitsanakis VA, Au C, Erikson KM, Aschner M. The effects of manganese on glutamate, dopamine and γ-aminobutyric acid Regulation. Neurochem Int 2006; 48:426-433.

Aschner M. The transport of manganese across the blood-brain barrier. Neurotoxicology 2006; 27: 311- 314.

Jiang GC-T, Aschner M. Neurotoxicity of depleted uranium – reasons for increased concern. Biol Trace Element Res 2006; 110:1-18.

Dobson A, Erikson KM, Lack K, Aschner M. Depleted uranium is not toxic to rat brain endothelial (RBE4) cells. Biol Trace Element Res 2006; 110:61-72.

Fitsanakis VA, Owens SE, dos Santos APM, Soldin OP, Aschner M. Manganese transport and neurotoxicity. Metal Ions Biol Med 2006; 9:101-107.

Aschner M, Fitsanakis VA, dos Santos APM, Olivi L, Bressler JP. Blood-brain barrier and cell-cell interactions: methods for establishing in vitro models of the blood-brain barrier and transport measurements. Methods Mol Biol 2006; 341:1-15.

Kaur P, Aschner M, Syversen T. Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes. Neurotoxicology 2006; 27:492-500.

Garcia JC, Gellein K, Syversen T, Aschner M. A manganese enhanced diet alters brain metals and transporters in the developing rat. Toxicol Sci 2006; 92:516-525.

Aschner M, Bernard A, de Burbure C. Correspondence: manganese as a potential confounder of serum prolactin. Environ Health Perspect 2006; 114:a458.

Erikson KM, Dorman DC, Fitsanakis VA, Lash LH, Aschner M. Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese. Biol Trace Element Res 2006; 111:199-215.

Fitsanakis VA, Erikson KM, Garcia SJ, Evje L, Syversen T, Aschner M. Brain accumulation of depleted uranium in rats following 3- or 6-month treatment with implanted DU pellets. Biol Trace Element Res 2006; 111:185-197.

Walker SJ, Segal S, Michael Aschner M. Cultured lymphocytes from autistic children and non-autistic siblings up-regulate heat shock protein RNA in response to thimerosal challenge. Neurotoxicology 2006; 27:685-692.

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JOURNAL ARTICLES Fitsanakis VA, Zhang N, Avison MJ, Gore JC, Aschner JL, Aschner M. The use of magnetic resonance imaging (MRI) in the study of manganese neurotoxicity. Neurotoxicology 2006; 27: 798-806.

Aschner M, Lukey B, Tremblay A. The Manganese Research Health Program (MHRP): Status report and future research needs and directions. Neurotoxicology 2006; 27:733-736.

Aschner M, Syversen T, Souza DO, Rocha JB. Metallothioneins: Mercury species-specific induction and their potential role in attenuating neurotoxicity. Exp Biol Med 2006; 231:1468-1473.

Gunter KK, Aschner M, Gunter TE. Speciation of manganese in cells and mitochondria: A search for the proximal cause of manganese neurotoxicity. Neurotoxicology 2006; 27:765-776.

Taylor MD, Erikson KM, Dobson AW, Fitsanakis VA, Dorman DC, Aschner M. Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain. Neurotoxicology 2006; 27:788-797.

Gunter KK, Aschner M, Miller LM, Eliseev R, Salter J, Anderson K, Gunter TE. Determining the oxidation states of manganese in NT2 cells and primary cultures of astrocytes. Neurobiol Aging 2006; 27:1816-1826.

2007 Aschner M, Dorman DC. Manganese: Pharmacokinetics and molecular mechanisms of brain uptake. Toxicol Rev 2007; 25:147-154.

Fitsanakis VA, Piccola G, dos Santos AP, Aschner J, Aschner M. Neurotoxicology, Putative proteins involved in manganese transport across the blood-brain barrier. Hum Exp Toxicol 2007; 26:295-302.

Garcia JC, Gellein K, Syversen T, Aschner M. Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain. Toxicol Sci 2007; 95:205-214.

Yin Z, Milatovic D, Aschner J, Syversen T, Rocha JBT, Souza DO, Sidoryk M, Albrecht J, Aschner M. Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes. Mol Brain Res 2007; 1131:1-10.

Kaur P, Aschner M, Syversen T. Role of glutathione in determining the differential sensitivity between the cortical and cerebellar regions towards mercury induced oxidative stress. Toxicology 2007; 230:164-77.

Erikson KM, Thompson K, Aschner JL, Aschner M. Manganese neurotoxicity: A focus on the neonate. Pharmacol Therap 2007; 113:369–377.

Gupta RC, Milatovic S, Dettbarn W-D, Aschner M, Milatovic D. Neuronal oxidative injury and dendritic damage induced by carbofuran: protection by memantine. Toxicol Appl Pharmacol 2007; 219:97-105.

Werdich AA, Jeyakumar LH, Fleischer S, Dzhura I, Kannankeril P, Baudenbacher F, Legrone A, Milatovic D, Aschner M, Atkinson, J, Strauss AW, Anderson M, Exil VJ. Polymorphic ventricular tachycardia and abnormal Ca2+ handling in very-long-chain acyl-CoA dehydrogenase null mice. Am J Physiol Heart Circ Physiol. 2007; 292:H2202-2211.

Aschner M, Syversen T, Souza DO, Rocha JBT, Farina M. Methylmercury neurotoxicity: Involvement of glutamate and reactive oxygen species. Brazil J Med Biol Res 2007; 40:285-291.

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JOURNAL ARTICLES Zhang Y, Milatovic D, Aschner M, Feustel PJ, Kimelberg HK. Neuroprotection by tamoxifen in focal cerebral ischemia is not dependent on the action at estrogen receptors but is associated with antioxidant activity. Exp Neurol 2007; 204:819-27.

Erikson KM, Dorman DC, Lash LH, Aschner M. Manganese inhalation by Rhesus monkeys is associated with brain regional changes in biomarkers of oxidative stress including glutamate transporters. Toxicol Sci 2007; 97:459-66.

Aschner M, Guilarte TR, Schneider JS, Zheng W. Manganese: Recent advances in its transport and neurotoxicity. Toxicol Appl Pharmacol 2007; 221:131-47.

Milatovic D, Yin Z, Gupta RC, Sidoryk M, Albrecht J, Aschner JL, Aschner M. Manganese induces oxidative impairment in cultured rat astrocytes. Toxicol Sci 2007; 98:198-205.

Brown LA, Khousbouei H, Goodwin JS, Irvin-Wilson CV, Ramesh A, Sheng L, McCallister MM, Jiang GC, Aschner M, Hood DB.. Downregulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene. Neurotoxicology 2007; 28:965-978.

Au C, Mutkus LA, Dobson AW, Riffle J, Lalli J, Aschner M. Effects of nanoparticles on the adhesion and cell viability in astrocytes. Biol Trace Element Res 2007; 120:248-256.

Soldin OP, Aschner M. Effects of manganese on thyroid hormone. Neurotoxicology 2007; 28:951-956.

Henshel D, Aschner M, Wolfe M, Basu N, Bowerman W, Echeverria D, Ralston N, Rumbold D. Status of mercury bioindicators in the fields of human health and wildlife toxicology. Environ Bioindicators 2008; 2:183 - 207.

Finkelstein Y, Milatovic D, Aschner M. Modulation of cholinergic systems by manganese. Neurotoxicology 2007; 28:1003-1014.

Kaur P, Schulz K, Aschner M, Syversen T. Role of docosahexaenoic acid in modulating methylmercury induced neurotoxicity. Toxicol Sci 2007; 100:423-432.

Aschner JL, Aschner M. Methylmercury neurotoxicity: Exploring potential novel targets. Open Toxicol Rev 2007; 1:1-10.

Blacher Y, Ashkenazi S, Shapira SC. E-letter to the Editor. Group of British doctors call for a boycott of the Israel Medical Association BMJ 2007; Brit Med J 2007;334:871.6

2008 Gellein K, Flaten TP, Erikson KM, Aschner M, Syversen T. Leaching of trace elements from biological tissue by formalin fixation. Biol Trace Elem Res 2008; 1211:221-225.

Stringari J, Nunes AKC, Franco JL, Bohrer D, Garcia SC, Dafre AL, Milatovic D, Souza DO, Rocha JBT, Aschner M, Farina M, Prenatal methylmercury exposure affects postnatal development of the glutathione antioxidant system in the mouse brain. Toxicol Appl Pharmacol 2008; 227:147-154.

Aschner M. Letter to the Editor. Response to article by DeSoto and Hitlan on the relationship between mercury exposure and autism. J Child Neurol 2008; 23:463-465.

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JOURNAL ARTICLES Yin Z, Aschner J, dos Santos APM, Aschner M. Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures. Mol Brain Res 2008; 1203:1-11.

Fitsanakis VA, Zhang N, Anderson JG, Erikson KM, Gore JC, Aschner M. Measuring brain manganese and iron accumulation in rats following 14-weeks of low-dose manganese treatment using atomic absorption spectroscopy (AAS) and magnetic resonance imaging (MRI). Toxicol Sci 2008; 103:116- 124.

Kaur P, Schulz K, Heggland I, Aschner M, Syversen T. The use of fluorescence for detecting MeHg- induced ROS in cell cultures. Toxicol in Vitro 2008; 22:1392-1398.

Erikson KM, Dorman DC, Lash LH, Aschner M. Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity. Neurotoxicology 2008; 29:377-385.

West AK, Hidalgo J, Levin ED, Aschner M. Metallothionein in the central nervous system: roles in protection, regeneration and cognition. Neurotoxicology 2008; 29:488-502.

Au C, Benedetto A, Aschner M. Manganese transport in eukaryotes: The role of DMT1. Neurotoxicology 2008; 29: 569-576.

Zaja-Milatovic S, Gupta RC, Aschner M, Montine TJ, Milatovic D. Pharmacologic suppression of oxidative damage and dendritic degeneration following kainic acid-induced excitotoxicity in mouse cerebrum. Neurotoxicology 2008; 29:621-627.

Aschner M, dos Santos APM, Erikson KM, Zheng W. Manganese transport into the brain: putative mechanisms. Metal Ions Biol Med 2008; 10:695-700.

Ineu RP, Pereira ME, Aschner M, Nogueira CW, Zeni G, Rocha JBT. Diphenyl diselenide reverses gastric lesions in rats: Involvement of oxidative stress. Food Chem Toxicol 2008; 46:3023-3029.

Leung MCK, Williams PL, Benedetto A, Au C, Helmcke KJ, Aschner M, Meyer JN. Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol Sci 2008; 106:5-28.

McCallister MM, Maguire M, Sheng L, Aschner M, Ebner FF, Hood DB. Prenatal exposure to benzo(a)pyrene during the period of neurogenesis results in reductions in cortical neuronal activity in the adult offspring. Neurotoxicology 2008; 29:846-854.

Yin Z, Jiyang H, Syversen T, Rocha JBT, Farina M, Aschner M. The methylmercury-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter, LAT1. J Neurochem 2008; 107:1083- 1090.

Kaur P, Heggland I, Aschner M, Syversen T. Docosahexaenoic acid may act as a neuroprotector for methylmercury-induced neurotoxicity in primary neural cell cultures. Neurotoxicology 2008; 29: 978- 987.

Ávila DS, Gubert P, Fachinetto R, Wagner C, Dalla Corte CL, Nogueira CW, Aschner M, Rocha JBT, Soares FAA. Involvement of striatal lipid peroxidation and inhibition of calcium influx into brain slices in

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JOURNAL ARTICLES neurobehavioral alterations in a rat model of short-term oral exposure to manganese. Neurotoxicology 2008; 29:1062-1068.

Marreilha dos Santos AP, Santos D, Au C, Milatovic D, Aschner M, Batoréu MCC. Anti-oxidants prevent the cytotoxicity of Mn in RBE4 Cells. Brain Res 2008; 1236C:200-205.

Soldin OP, O’Mara DM, Aschner M. Thyroid hormones and methylmercury toxicity. Biol Trace Elem Res 2008; 126:1-12.

Yin Z, Jiyang H, Syversen T, Rocha JBT, Farina M, Aschner M. The methylmercury-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter, LAT1. J Neurochem 2008; 107:1083- 1090.

McCaughan D, Au C, Benedetto A, Milatovic D, Aschner J, Aschner M. Bilirubin acts as an antioxidant in C. elegans. J Neuroprot Neuroregen 2008; 4:252-262.

Finkelstein Y, Zhang N, Fitsanakis VA, Avison MC, Gore JC, Aschner M. Differential deposition of manganese in the rat brain following subchronic exposure to manganese: a T-1 weighted MRI study Isr Med Assoc J 2008; 10:793-798.

2009 Wang L, Jiang H, Aschner M, Cai J. Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes. Toxicol Sci 2009; 107:135-143.

Fitsanakis VA, Thompson KN, Deery SE, Milatovic D, Shihabi ZK, Brown RW, Aschner M. A chronic iron-deficient/high-manganese diet in rodents results in increased brain oxidative stress and behavioral deficits in the Morris water maze. Neurotox Res 2009; 15:167-178.

Martins Rde P, Braga Hde C, da Silva AP, Dalmarco JB, de Bem AF, Dos Santos AR, Dafre AL, Pizzolatti MG, Latini A, Aschner M, Farina M. Synergistic neurotoxicity induced by methylmercury and quercetin in mice. Food Chem Toxicol 2009; 47:645-649.

Roos DH, Puntel RL, Santos MM, Souza DOG, Farina M, Nogueira CW, Aschner M, Burger M, Rocha JBT. Guanosine and synthetic organoselenium compounds modulate methylmercury-induced oxidative stress in rat brain cortical slices: Involvement of glutamatergic system. Toxicol In Vitro 2009; 23:302- 307.

de Freitas AS, Funck VC, dos Santos Rotta M, Bohrer D, Mörschbächer V, Puntel RL, Nogueira CW, Farina M, Aschner M, Rocha JBT. Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice. Brain Res Bull 2009; 79:77-84.

Kaur P, Evje L, Aschner M, Syversen T. The in vitro effects of selenomethionine on methylmercury- induced neurotoxicity. Toxicol In Vitro 2009; 23:378–385.

Milatovic D, Aschner M. Measurement of isoprostanes as markers of oxidative stress in neuronal tissue. Curr Protocol Toxicol 2009; 12.14:1-12.

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JOURNAL ARTICLES Cowan DM, Fan QY, Zou Y, Shi XJ, Chen J, Aschner M, Rosenthal F, Zheng W. Manganese exposure among smelting workers: Blood manganese-iron ratio as a novel tool for manganese exposure assessment. Biomarkers, 2009; 14:3-16.

Zhang N, Fitsanakis VA, Erikson KM, Aschner M, Avison, MJ, Gore JC. A model for the analysis of competitive relaxation effects of manganese and iron in vivo. NMR Biomed 2009; 22:391-404.

Fitsanakis VA, Finkelstein Y, Aschner M. Changes in dietary iron levels affect brain manganese accumulation and distribution. Cell Biol Toxicol 2009; 25:185–189.

Aschner M. Invited foreword to metal speciation related to neurotoxicity in humans, Michalke B, Halbach S, Nischwitz V. J Environ Monitor 2009; 11:937-938.

Yin Z, Albrecht J, Syversen T, Jiang H, Summar M, Rocha JBT, Farina M, Aschner M. Comparison of alterations in amino acids content in cultured astrocytes or neurons exposed to methylmercury separately or in co-culture. Neurochem Int 2009; 55:136-142.

Santos DB, Schiar VP, Ribeiro MC, Schwab RS, Meinerz DF, Allebrandt J, Rocha JB, Nogueira CW, Aschner M, Barbosa NB. Genotoxicity of organoselenium compounds in human leukocytes in vitro. Mut Res 2009; 676:21-26.

Rongzhu L, Suhua W, Guangwei X, Chunlan R, Fangan H, Junjie J, Aschner M. Zinc, copper, iron and selenium levels in brain and liver of mice exposed to acrylonitrile. Biol Trace Elem Res 2009; 130:39- 47.

Lee ES, Jiang H, Yin Z, Milatovic D, Aschner M. Estrogen and tamoxifen protect against Mn-induced toxicity in rat cortical primary cultures of neurons and astrocytes. Toxicol Sci 2009; 110:156-67.

Lee, ES, Aschner M. Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes. J Neurochem 2009; 110:530-544.

Stanwood GD, Leitch DB, Savchenko V, Wu J, Fitsanakis VA, Aschner M, McLaughlin BA. Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. J Neurochem 2009; 110:378-389.

Sidoryk-Węgrzynowicz M, Lee E, Albrecht J, Aschner M. Manganese disrupts astrocyte glutamine transporter expression and function. J. Neurochem 2009; 110:822-830.

Rongzhu L, Suhua W, Guangwei X, Chunlan R, Fangan H, Suxian C, Aschner M, Zhengxian Z, Qiuwei Z. Effects of acrylonitrile on antioxidant status of different brain regions in rat. Neurochem Internat 2009; 55:552-557.

Jiang GC-T, Hughes S, Stürzenbaum SR, Evje L, Syversen T, Aschner M. Caenorhabditis elegans metallothioneins protect against toxicity induced by depleted uranium. Toxicol Sci 2009; 111:345-354.

Santos DB, Schiar VPP, Paixão MW, Rocha JBT, Nogueira CW, Aschner M, Barbosa NBV. Hemolytic and genotoxic evaluation of organochalcogens in human blood cells in vitro. Toxicol in vitro 2009; 23:1195-1204.

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JOURNAL ARTICLES Dennis KE, Aschner JL, Milatovic D, Schmidt JW, Aschner M, Kaplowitz MR, Zhang Y, Fike CD. NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets. Am J Physiol 2009; 297:L596-607.

Zaja-Milatovic S, Gupta RC, Aschner M, Milatovic D. Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist. Toxicol Appl Pharmacol 2009; 240:124-31.

Milatovic D, Zaja-Milatovic S, Gupta RC, Yu Y, Aschner M. Oxidative damage and neurodegeneration in manganese-induced neurotoxicity. Toxicol Appl Pharmacol 2009; 240:219-25.

Helmcke KJ, Syversen T, Miller DM, III, Aschner M. 2009. Characterization of the effects of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol 2009; 240:265-72.

Halladay A, Amaral D, Aschner M, Bolivar V, Bowman AB, DiCicco-Bloom E, Hyman S, Keller F, Lein P, Pessah I, Restifo I, Threadgill D. Animal Models of Autism Spectrum Disorders: Information for Neurotoxicologists. Neurotoxicology 2009; 30:811-21.

Benedetto A, Au C, Aschner M. Manganese-induced dopaminergic neurodegeneration: Insights into mechanisms and genetics shared with Parkinson’s disease. Chem Rev 2009; 109:4862-84.

NDERBILT, Aschner M, Heberlein U, Ruden D, Welsh-Bohmer KA, Bartlett S, Berger K, Chen L, Corl AB, Eddins D, French R, Hayden KM, Helmcke KJ, Hirsch HVB, Linney E, Lnenicka G, Page GP, Kirshner A. Genetic aspects of behavioral neurotoxicology. Neurotoxicology 2009; 30:741-53.

Aschner M. Nanoparticles: Transport across the olfactory epithelium and application to the assessment of brain function in health and disease. Prog Brain Res 2009; 180:141-152.

Au C, Benedetto A, Anderson J, Labrousse A, Erikson KM, Ewbank J, Aschner M. Differential role of C. elegans NRAMP orthologues in manganese physiology. PLoS One 2009; 4:e7792.

Aschner M, Erikson K, Herrero-Hernández E, Tjalkens R. Manganese and its role in Parkinson's disease: from transport to neuropathology. NeuroMol Med 2009; 11:252–266.

Jiang GC-T, Aschner M. Toxicity studies on depleted uranium in primary rat cortical neurons and in Caenorhabditis elegans: what have we learned? J Toxicol Environ Health 2009; 12:525-539.

Ali S, Jiang H, Rongzhu L, Milatovic D, Aschner M. Methamphetamine dysregulates redox status in primary astrocyte ad neuronal cultures. Am J Neuroprot Neuroregen 2009; 1:52-59.

Wagner C, Vargas AP, Ross DH, Morel AF, Farina M, Nogueira CW, Aschner M, Rocha JBT. Comparative study of quercetin and its two glycosides forms quercitrin and rutin against MeHg-induced ROS production in vitro. Arch Toxicol 2009; 84:89-97.

da Conceição Nascimento Pinheiro M, Martins do Nascimento L, de Lima Silveira LC, Rocha JBT, Aschner M. Mercury and selenium – a review of some aspects related to the health of human populations in the Amazon. Environ Bioindicat 2009; 4:222-245.

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JOURNAL ARTICLES

2010 Helmcke KJ, Ávila DS, Aschner M. Utility of Caenorhabditis elegans in high throughput neurotoxicological research. Neurotoxicol Teratol 2010; 32:62-67.

Aschner M, Crofton KM, Levin ED. Introduction: Emerging high throughput and complementary model screens for neurotoxicology. Neurotoxicol Teratol 2010; 32:1-3.

Yin Z, Jiang H, Lee ES, Ni M, Erikson KM, Milatovic D, Bowman AB, Aschner M. Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation. J Neurochem 2010; 112:1190-1198.

Milatovic D, Montine T, Zaja-Milatovic S, Madison J, Bowman AB, Aschner M. Morphometric analysis in neurodegenerative disorders. Curr Protocol Toxicol 2010; 12.16.1-12.16.14.

Williams JM, Milatovic D, Gore JC, Aschner M, Avison MJ. Chronic exposure to manganese induces an amphetamine-resistant phenotype: a pharmacologic magnetic resonance imaging study. Toxicol Sci 2010; 114:310-322.

Williams BB, Li D, Wegrzynowicz M, Vadodaria BK, Anderson JG, Kwakye GF, Aschner M, Erikson KM, Bowman AB. Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure. J Neurochem 2010; 112:227-237.

Guangwei X, Rongzhu L, Wenrong X, Suhua W, Xiaowu Z, Shizhong W, Zhang Ye Z, Aschner M, Kulkarni SK, Bishnoi M. Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats. Toxicology 2010; 267:140-146.

Fitsanakis VA, Zhang N, Garcia S, Aschner M. Manganese and iron: Interdependency of transport and regulation. Neurotoxic Res 2010; 18:59-68.

Suhua W, Rongzhu L, Wenrong X, Guangwei X, Xiaowu Z, Shizhong W, Ye Z, Aschner M. Induction or Inhibition of cytochrome P450 2E1 modifies the acute toxicity of acrylonitrile in rats: Biochemical evidence. Arch Toxicol 2010; 84:461-469.

Aschner M, Ceccatelli S. Are neuropathological conditions relevant to ethylmercury exposure? Neurotoxic Res 2010; 18:59–68.

Ávila DS, Colle D, Gubert P, Schwertner Palma A, Puntel G, Manarin F, Noremberg S, Nascimento PC, Aschner M, Wayne Nogueira C, Rocha JBT, Soares FAA. A possible neuroprotective action of a vinylic telluride against Mn-induced neurotoxicity. Toxicol Sci 2010; 115:194-201.

Marreilha dos Santos AP, Milatovic D, Au C, Yin Z, Aschner M, Batoréu C. Rat Brain Endothelial cells are a target of manganese toxicity. Brain Res 2010; 1326:152-161.

Martinez K, Kennedy A, West T, Milatovic D, Aschner M, McIntosh M. Trans-10, cis-12 conjugated linoleic acid promotes inflammation to a greater extent in human adipocytes compared to preadipocytes. J Biol Chem 2010; 285:17701-17712.

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JOURNAL ARTICLES Suhua W, Rongzhu L, Changqing Y, Guangwei X, Fangan H, Junjie J, Wenrong X, Aschner M. Lipid peroxidation and changes of trace metals in mice following para-dichlorobenzene exposure. Biol Trace Elem Res 2010; 136: 320-336.

Ni M, Aschner M. Neonatal rat primary microglia: isolation, culturing and selected applications. Curr Protocol Toxicol 2010; 43:12.17.1-12.17.16.

Ni M, Li X, Yin Z, Jiang H, Sidoryk-Węgrzynowicz M, Milatovic H, Cai J, Aschner M. Methylmercury induces acute oxidative stress, altering NRF2 protein levels in primary microglia. Toxicol Sci 2010; 116: 590-603.

Benedetto A, Au C, Ávila DS, Milatovic D, Aschner M. Extracellular dopamine potentiates Mn-induced oxidative stress, lifespan reduction and dopaminergic neurodegeneration in a BLI-3-dependent manner in C. elegans. PLoS Genet 2010; 6:e1001084. doi:10.1371/journal.pgen.1001084.

Hood J, Jenkins JW, Milatovic D, Rongzhu L, Aschner M. Mefloquine induces oxidative stress and neurodegeneration in primary rat cortical neurons. Neurotoxicology 2010; 31:518-523.

Aschner M, Levin ED, Suñol C, Olopade JO, Helmcke KJ, Ávila DS, Sledge D, Ali RH, Upchurch L, Donerly S, Linney E, Forsby A, Ponnuru P, Connor JR. Gene-environment Interactions: neurodegeneration in non-mammals and mammals. Neurotoxicology 2010; 31:582–588.

Williams BB, Kwakye GF, Węgrzynowicz M, Li D, Aschner M, Erikson KM, Bowman AB. Altered Manganese Homeostasis and Manganese Toxicity in a Huntington's Disease Striatal Cell Model Are Not Explained by Defects in the Iron Transport System. Toxicol Sci 2010; 117:169-179.

Puntel RL, Roos DH, Folmer V, Nogueira CW, Galina A, Aschner M, Rocha JBT. Mitochondrial dysfunction induced by different organochalchogens is mediated by thiols oxidation and is not dependent of the classical mitochondrial permeability transition pore opening. Toxicol Sci 2010; 117:133-43.

Roos DH, Puntel RL, Logokensk TH, Ineu RP, Bohrer D, Burger ME, Franco JL, Farina M, Aschner M, Rocha JBT, Barbosa NBV. Complex methylmercury-cysteine alters mercury accumulation in different tissues of mice. Basic Clin Pharmacol Toxicol 2010; 107:789-792.

Finkelstein Y, Fox DA, Aschner M, Boyes W. Gene-Environment Interactions in Neurotoxicology: The 12th Biennial Meeting of the International Neurotoxicology Association. Neurotoxicology 2010; 31:543- 544.

Finkelstein Y, Milatovic D, Lazarovici P, Ophir A, Richter ED, Aschner M, Lecht S, Marcinkiewicz C, Lelkes PI, Zaja-Milatovic S, Gupta RC, Brodsky B, Rosengarten A, Proscura E, Shapira E, Wormser U. Peaceful use of disastrous neurotoxicants. Neurotoxicology 2010; 31:608-620.

Kaur P, Evje L, Aschner M, Syversen T. The in vitro effects of Trolox on methylmercury-induced neurotoxicity. Toxicology 2010; 276:73-78.

Aschner M, Onishchenko N, Ceccatelli S. Toxicology of Alkyl-Mercury Compounds. In: Metal Ions in Life Sciences, Volume 7, Organometallics in Environment and Toxicology, Sigel A, Sigel H, Sigel RKO, Eds. Cambridge, UK: The Royal Society of Chemistry, 2010; 7:403-434.

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JOURNAL ARTICLES Sidoryk-Węgrzynowicz M, Lee, E-S, Aschner M. Manganese-induced downregulation of astroglial glutamine transporter SNAT3 involves ubiquitin-mediated proteolytic system. Glia 2010; 58:1905-1912.

Helmcke KJ, Aschner M. Hormetic effect of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol 2010; 248:156-164.

Stein Y, Finkelstein Y, Levy-Nativ O, Bonne O, Aschner M, Richter ED. Exposure and susceptibility: Schizophrenia in a young man following prolonged high exposures to organic solvents. Neurotoxicology 2010; 31:601-607.

Sheng L, Ding X, Ferguson M, McCallister M, Rhoades R, Maguire M, Ramesh A, Aschner M, Campbell D, Levitt P, Hood DB. Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and reduced expression of the autism risk gene, MET receptor tyrosine kinase. Toxicol Sci 2010; 118:625-634.

Exil V, Ávila DS, Benedetto A, Exil E, Au, C, Adams MR, Aschner M. Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans. PLoS One 2010; 5:e14228. doi:10.1371/journal.pone.0014228.

Franco JL, Posser T, Missau T, Pizzolatti MG, dos Santos ARS, Souza DO, Aschner M, Rocha JBT, Dafre AL, Farina M. Structure-activity relationship of flavonoids derived from medicinal plants in preventing methylmercury-induced mitochondrial dysfunction. J Environ Toxicol Pathol 2010; 30:272- 278.

Obara-Michlewska M, Jiang H, Albrecht J, Aschner M. Modulation of potassium (rubidium) fluxes and cell volume changes by Kir4.1 channel in HEKT293 cells exposed to ammonia and/or hypotonia. Pharmacol Reports 2010; 62:1237-42.

2011 Schusheim S, Aschner M, Brodsky B, Proscura E, Erlanger-Rosengarten A, Feldman R, Shapira E, Wormser U. Anti-inflammatory effects of novel peptides. Peptides 2011; 32:125-30.

Meinerz DF, Sudati JH, dos Santos DB, Frediani A, Alberto EE, Allebrandt J, Franco JL, Barbosa NBV, Aschner M, Rocha JBT. Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluro amino acid derivative of aspartic acid. Arch Toxicol 2011; 85:43- 9.

Aitlhadj L, Ávila DS, Benedetto A, Aschner M, Sturzenbaum SR. Environmental exposure, obesity and Parkinson’s disease: Lessons from fat and old worms. Environ Health Perspect 2011; 119:20-8.

Dydak U, Jiang Y, Long L, Zhu H, Li WM, Chen J, Long Z, Fu X, Hu S, Edden RAE, Meier D, Aschner M, Harezlak J, Murdoch J, Zheng W. Alteration in brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese. Environ Health Perspect 2011; 119:219-24.

Shelton R, Sidoryk-Węgrzynowicz M, Reddy R, Aschner M, Lewis DL, Mirnics K. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol Psychiat 2011; 16:751-62.

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JOURNAL ARTICLES Sidoryk-Węgrzynowicz M, Węgrzynowicz M, Lee, E-S, Bowman AB, Aschner M. Role of astrocytes in nervous system disease. Toxicol Pathol 2011; 39:115-23.

Fitsanakis V, Zhang N, Erikson KM, Avison MC, Gore JC, Aschner M. Changes in dietary iron exacerbate regional brain manganese accumulation as determined by magnetic resonance imaging. Toxicol Sci 2011; 120:146-53.

Martinez-Finley E, Chakraborty S, Ávila DS, Aschner M. Insights from C. elegans on the role of metals in neurodegenerative diseases. Metallomics 2011; 3:271-9.

Dos Santos APM, Santos ML, Dias D, Aschner M, Batoréu CM. Search for biomarkers to control and prevent the risk of neurotoxicity induced in rats sub-acutely exposed to MnCl2. Brain Res 2011; 1382:282-90.

Roos DH, Puntel RL, Farina M, Aschner M, Bohrer D, Rocha JBT, Barbosa NBV. Modulation of methylmercury uptake by methionine: Prevention of mitochondrial dysfunction in rat liver slices by a mimicry mechanism. Toxicol Appl Pharmacol 2011; 252:28-35.

Zhaobao Y, Lee ES, Ni M, Jiang H, Milatovic D, Farina M, Rocha JBT, Aschner M. Methylmercury- induced alterations in astrocyte functions are attenuated by ebselen. Neurotoxicology 2011; 32:291-9.

Ni M, Li X, Yin Z, Sidoryk-Węgrzynowicz M, Jiang H, Farina M, Rocha JBT, Syversen T, Aschner M. Comparative study on the response of rat primary astrocytes and microglial cells to methylmercury toxicity. Glia 2011; 59:810-20.

Milatovic D, Montine TJ, Aschner M. Prostanoids signaling: dual role for PGE2 in neurotoxicity Neurotoxicology 2011; 32:312-9.

Caito SW, Milatovic D, Hill KE, Aschner M, Burk RF, Valentine WM. Progression of neurodegeneration and morphologic changes in the brains of juvenile mice with selenoprotein P deleted. Brain Res 2011; 1398:1-12.

Aschner M. Astrocytic swelling. In: In vitro neurotoxicology – methods and protocols. Method Mol Biol 758:391-402.

Milatovic D, Montine TJ, Aschner M. Measurement of isoprostanes as markers of oxidative stress. In: in vitro neurotoxicology – methods and protocols. Method Mol Biol 758:195-204.

Sidoryk-Węgrzynowicz M, Lee ES, Ni M, Aschner M. Protein kinase Cδ is involved in manganese- mediated disruption of glutamine turnover in astrocytes. Glia 2011; 59:1732–1743.

Farina M, Rocha JBT, Aschner M. Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci 2011; 89:555-63.

Albrecht J, Sidoryk-Węgrzynowicz M, Zielińska M, Aschner M. Role of glutamine in neurotransmission. Neuron Glia Biol 2011; Neuron Glia Biol 21:1-14.

Farina M, Aschner M, Rocha JBT. Oxidative stress in MeHg-induced neurotoxicity. Toxicol Appl Pharmacol 2011; 256:405-17.

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JOURNAL ARTICLES Le TM, Jiang H, Cunningham GR, Magarik JA, Barge WS, Cato MC, Lee ES, Farina M, Rocha JBT, Milatovic D, Lee ES, Summar ML, Aschner M. γ-glutamylcysteine ameliorates oxidative injury in neurons and astrocytes in vitro and increases brain glutathione in vivo. Neurotoxicology 2011; 32:518- 25.

Milatovic D, Jenkins JW, Hood J, Yu Y, Rongzhu L, Aschner M. Mefloquine neurotoxicity is mediated by non-receptor tyrosine kinase. Neurotoxicology 2011; 32:578-85.

Milatovic D, Aschner M. Response to Nevin, RL: Mefloquine neurotoxicity and gap junction blockade: Critical insights in drug repositioning. Neurotoxicology 2011; 32; 987.

Madison JL, Węgrzynowicz M, Aschner M, Bowman AB. Gender and manganese exposure interactions on mouse striatal neuron morphology. Neurotoxicology 2011; 32; 896-906.

Owens SE, Summar ML, Ryckman KK, Haines JL, Summar SR, Aschner M. Polymorphisms in four heavy metal regulatory genes do not associate with autism. Neurotoxicology 2011; 32; 769-775.

Milatovic D, Gupta R, Yin Y, Zaja-Milatovic S, Aschner M. Protective effects of antioxidants and anti- inflammatory agents against manganese-induced oxidative damage and neuronal injury. Toxicol Appl Pharmacol 2011; 256:219-26.

Bowman AB, Kwakye G, Herrero Hernández E, Aschner M. Role of Mn in neurodegenerative disease, J Trace Elem Med Biol 2011; 25:191-203.

Ávila DS, Au C, Benedetto A, Aschner M. The role of smf transporters and dopamine in manganese- induced neurodegeneration in C. elegans. Proceedings of the 11th International Symposium on Metal Ions in Biology and Medicine, Pele L, Powell JJ, Kinrade S, Jugdaohsingh R, Collery P, Maymard I, Badawi A, Eds. Cambridge, UK, John Libbey Eurotext, Paris; ISBN: 978-2-7420-0809-4, 2011.

2012 Antonelli M, Guillemin GJ, Raisman-Vozari R, Del-Bel EA, Aschner M, Collins MA, Tizabi Y, Moratalla R, West AK. New strategies in neuroprotection and neurorepair. Neurotox Res 2012; 21:49-56.

Martins EN, Pessano NTC, Leal L, Roos DH, Folmer V, Puntel GO, Rocha JBT, Aschner M, Ávila DS, Puntel RL. Protective effect of Melissa officinalis aqueous extract against Mn-induced oxidative stress in chronically exposed mice. Brain Res Bull 2012; 87:74-9.

Li Z, Chadalapaka G, Ramesh A, Khoshboue H, Maguire M, Safe S, Rhoades RE, Clark R, Jules G, McCallister M, Aschner M, Hood DB. PAH particles perturb prenatal processes and phenotypes: Protection from deficits in object discrimination afforded by dampening of brain-oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Toxicol Sci 2012; 125:233-47.

Marreilha dos Santos AP, Lucas RL, Andrade V, Mateus ML, Milatovic D, Aschner M, Batoreu MC. Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)- induced neurotoxicity. Toxicol Appl Pharmacol 2012; 258:394-402.

Santos D, Milatovic D, Sidoryk-Wegrzynowicz M, Andrade V, Batoreu MC, Aschner M, Marreilha dos Santos AP. The inhibitory effect of manganese on acetylcholinesterase activity can enhance oxidative stress and neuroinflammation in rat brain. Toxicology 2012; 292:90-8.

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JOURNAL ARTICLES Skowrońska M, Zielińska M, Wójcik-Stanaszek L, Ruszkiewicz J, Milatovic D, Aschner M, Albrecht J. Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases. J Neurochem 2012; 121:125-34.

Lee E, Yin Z, Sidoryk-Węgrzynowicz M, Jiang H, Aschner M. 15d-PGJ2 modulates manganese-induced activation of NF-kB, Nrf2 and PI3K pathways. Free Rad Biol Med 2012; 52:1067-74.

Madison JL, Węgrzynowicz M, Aschner M, Bowman AB. Manganese exposure yields genotype- dependent acute and chronic alterations in striatal neurochemistry but exhibits minimal influence on early changes in medium spiny neuron morphology in YAC128 mice. PLos One 2012; 7(2):e31024.

Cordoval MF, Aguiar AS Jr, Peres TV, Lopes MW, Gonçalves FM, Remor AP, Lopes SC, Pilati C, Latini AS, Prediger RDS, Erikson KM, Aschner M, Leal RB. In vivo manganese exposure modulates ERK, AKT, and DARP-32 in the striatum of developing rats and impairs their motor activity. PLoS One 2012; 7(3):e33057.

Dopp E, Bhattacharya S, Hirner AV, Aschner M, Schwerdtle T. Editorial, special issue on toxicity of organometal(loid)s. J Toxicol 2012; Article ID 358484.

Martinez-Finley E, Aschner M. Metals and disease: Revelations from the nematode C. elegans on the complex interplay of cell defense mechanisms. J Toxicol 2012; Article ID 895236.

Kaur P, Aschner M, Syversen T. Biochemical factors modulating cellular toxicity of methylmercury. J Toxicol 2012; Article ID 721987.

Criswell SR, Perlmutter JS, Huang J, Golchin N, Flores HP, Hobson A, Aschner M, Erikson KM, Checkoway H, Racette BA. Basal ganglia intensity indices and diffusion weighted imaging in manganese exposed welders. Occup Environ Med 2012; 69:437-43.

Ávila DS, Benedetto A, Au A, Manarin F, Erikson KM, Soares FA, Rocha JBT, Aschner M. Organotellurium and organoselenium compounds attenuate Mn-induced toxicity in Caenorhabditis elegans by preventing oxidative stress. Free Rad Biol Med 2012; 52:1903-10.

Lee E, Sidoryk-Węgrzynowicz M, Griffin B, Yin Z, Son D-S, Aschner M. Transforming growth factor-α mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes. Glia 2012; 60:1024-36.

Aschner M. Considerations on methylmercury (MeHg) treatments in in vitro studies. Neurotoxicology 2012; 33:512-3.

Perera FP, Li TY, Lin C, Tang D, Gilbert SG, Kang S-K, Aschner M. Current needs and future directions of occupational safety and health in a globalized world. Neurotoxicology 2012; 3:805-809.

Wormser U, Brodsky B, Milatovic D, Finkelstein Y, Farina M, Rocha JB, Aschner M. Protective effect of a novel peptide against methyl mercury-induced toxicity in rat primary astrocytes. Neurotoxicology 2011; 3:763-768.

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JOURNAL ARTICLES Ávila DS, Helmcke KJ, Aschner M. The C. elegans model as a reliable tool in toxicology. J Human Exp Toxicol 2012; 10.1177/0960327110392084.

Racette BA, Aschner M, Guilarte TR, Dydak U, Criswell SR, Zheng W. Pathophysiology of manganese- associated neurotoxicity. Neurotoxicology 2012; 33:881-886. Caito S, Fretham S, Martinez-Finley E, Chakraborty S, Avila D, Chen P, Aschner M. Genome wide analyses of metal responsive genes in Caenorhabditis elegans. Frontiers Toxicogenom 2012; 3:52.

Martinez-Finley E, Chakraborty S, Fretham S, Aschner M. Cellular transport and homeostasis of essential and nonessential metals. Meatllomics 2012; 4:593-605.

Aschner M. Book Review, Metal Ions in Toxicology: Effects, interactions, interdependencies. Coord Chem Rev 2012; 256:369.

Ávila DS, Somlyai G, Somlyai I, Aschner M. Anti-aging effects of deuterium depletion in a C. elegans model. Toxicol Lett 2012; 211:319-324.

Fatima T, Sidoryk-Wegrzynowicz M, Yu Y, Wormser U, Aschner M. Effects of IIIM1 on rat astrocytes. Young Sci J 2012; 2:8-10.

Sidoryk-Wegrzynowicz M, Lee E, Aschner M. Mechanism of Mn(ii)-mediated dysregulation of the glutamine–glutamate cycle: focus on glutamate turnover. J Neurochem 2012; 122:856-867.

Santos D, Milatovic D, Sidoryk-Wegrzynowicz M, Andrade V, Batoreu MC, Aschner M, Marreilha dos Santos AP. Letter to the Editor, Response. The inhibitory effect of manganese on acetylcholinesterase activity can enhance oxidative stress and neuroinflammation in rat brain. Toxicology 2012; 298:61-62.

Fike C, Sidoryk-Węgrzynowicz M, Aschner J, Summar M, Cunningham G, Kaplowitz M, Zhang Y, Aschner M. Prolonged hypoxia augments L-citrulline transport by System A in the newborn piglet pulmonary circulation. Cardiovasc Res 2012; 95:375-384.

Chakraborty S, Aschner M. Altered manganese homeostasis: Implications for bli-3-dependent dopaminergic neurodegeneration and skn-1 protection in C. elegans. J Trace Elem Med Biol 2012; 26:183-187.

Fox DA, Lucchini R, Aschner M, Chen J, Boyes WK, Llorens J. Editorial: Local effects and global impact in neurotoxicity and neurodegeneration: The Xi’an International Neurotoxicology Conference. 2012; Neurotoxicology 4:629-630.

Fretham SJB, Caito S, Martinez-Finley EJ, Aschner M. Mechanisms and modifiers of methylmercury- induced neurotoxicity. Toxicol Res 2012; 1:32-38.

Ni M, Li X, Rocha JBT, Farina M, Aschner M. Glia and methylmercury neurotoxicity. J Toxicol Environ Health A 2012; 75:1091-1101.

Lee E, Sidoryk-Węgrzynowicz M, Wang N, Webbs A, Son D-S, Aschner M. GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes. J Biol Chem 2012; 287:26817-26828.

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JOURNAL ARTICLES Comparsi B, Meinerz DF, Franco JL, Posser T, de Souza Prestes A, Stefanello ST, dos Santos Prestes DB, Wagner C, Farina M, Aschner M, Dafre AL, Rocha JBT. Diphenyl ditelluride targets brain selenoproteins in vivo: Inhibition of cerebral thioredoxin reductase and glutathione peroxidase in mice after acute exposure. Mol Cell Biochem 2012; 370:173-182.

Sturzenbaum SR, Freedman JF, Aschner M. Toxicogenomics in non-mammalian species - Editorial. Front Genet 2012; 3:216.

Rocha JBT, Aschner M, Dórea JG, Ceccatelli S, Farina M, Silveira LCL. Mercury toxicity, Editorial. J Biomed Biotechnol 2012; 2012:831890.

Moreira ELG, de Oliveira J, Dutra MF, dos Santos DB, Gonçalves CA, Goldfeder E, de Bem AF, Prediger RDS, Aschner M, Farina M. Does methylmercury-induced hypercholesterolemia play a causal role in its neurotoxicity and cardiovascular disease? Toxicol Sci 2012; 130:373-82.

Costa LG, Aschner M. Editorial. BMC Pharmacol Toxicol 2012; 13:16.

Santos D, Batoreu MC, Isabel A, Ruben R, Sidoryk-Wegrzynowicz M, Aschner M, Marreilha dos Santos AP. Manganese alters rat brain amino acid levels in vivo. Biol Trace Elem Res 2012; 150:337-41.

Dalla Cortea CL, Soares FAA, Aschner M, Rocha JBT. Diphenyl diselenide prevents methylmercury- induced mitochondrial dysfunction in rat liver slices. Tetrahedron 2012; 68:10437-10443.

2013 Lee E, Sidoryk-Wegrzynowicz M, Aschner M. Manganese-induced deregulation of astrocytic glutamate transport is attenuated by 17-estradiol and selective estrogen receptor modulators. Neurotox Res 2013; 23:124-130.

Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Aschner M, Yule DI. Manganese transport via the transferrin mechanism. Neurotoxicology 2013; 34:118-127.

López-Granero C, Cañadas F, Cardona D, Yu Y, Giménez E, Lozano R, Avila DS, Aschner M. Sánchez-Santed F. Chlorpyrifos-, diisopropylphosphorofluoridate- and parathion-induced behavioral and oxidative stress effects: Are they mediated by analogous mechanisms of action? Toxicol Sci 2013; 131: 206-216.

Kumar KK, Aboud AA, Patel DK, Aschner M, Bowman AB. Optimization of fluorescence assay of cellular manganese status for high throughput screening. J Biochem Mol Toxicol 2013; doi: 10.1002/jbt.21457.

Santos D, Batoreu CM, Aschner M, Marreilha dos Santos AP. Comparison between 5-aminosalicylic acid (5-ASA) and para-aminosalicylic acid (4-PAS) as potential protectors against Mn-induced neurotoxicity. Biol Trace Elem Res 2013; 152:113-116.

Prabhakarpandian B, Shen M-C, Nichols J, Mills I, Sidoryk-Wegrzynowicz M, Aschner M, Pant K. SyM- BBB: Microfluidic blood-brain barrier model. Lab Chip 2013; 13:1093-1101.

DeWitt MR, Chan P, Aschner M. Manganese efflux in Parkinsonism: Insights from newly characterized SLC30A10 mutations. Biochem Biophys Res Communic 2013; 432:1-4.

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JOURNAL ARTICLES Maitre NL, Aschner JL, Aschner M. Letter to the Editor. Early life iron deficiency impairs spatial cognition in neonatal piglets. J Nutr 2013; 143:548.

Farina M, Avila DS, Rocha JBT, Aschner M. Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury. Neurochem Int 2013; 62:575-94.

Stephenson AP, Schneider JA, Nelson BC, Atha DH, Jain A, Soliman KF, Aschner M, Mazzio E, Reams RR. Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: Attenuation of thymine base lesions by glutathione and N-acetylcysteine. Toxicol Lett 2013; 218:299-307.

Yuanqing H, Suhua W, Guangwei X, Hai Q, Wenrong X, Aschner M, Milatovic D, Rongzhu L. Acrylonitrile has distinct hormetic effects on acetylcholinesterase activity in mouse brain and blood that are modulated by ethanol. Dose-Response 2013; 11:49–59, 2013.

Zhang Y, Yu F, Lu R, Liu Y, Wu Y, Qian H, Zhao X, Wang S, Xing G, Aschner M. Hormetic effects of acute methylmercury exposure on GRP78 expression in rat brain cortex. Dose-Response 2013; 11:109–120.

Roth J, Ponzoni S, Aschner M. Manganese homeostasis and transport. In: Metal Ions in Life Sciences, Volume 12, Metallomics and the Cell, Banci L, Volume Ed, Sigel A, Sigel H, Sigel RKO, Series Eds. Cambridge, UK: The Royal Society of Chemistry, 2013; 12:169-201.

Sidoryk-Wegrzynowicz M, Aschner M. Role of manganese in the glutamine/glutamate-γ-aminobutyric acid (GABA) cycle. J Internal Med 2013; 273:466-477.

Puntel RL, Roos DH, Aschner M, Rocha JBT. Organochalcogens inhibit mitochondrial complexes I and II in rat brain: possible implications for neurotoxicity. Neurotox Res 2013; 24:109-118.

Cordova FM, Aguiar AS Jr, Peres TV, Lopes MW, Gonçalves FM, Pedro DZ, Lopes SC, Pilati C, Prediger RDS, Farina M, Erikson KM, Aschner M, Leal RB. Oxidative stress is involved in striatal neurotoxicity in manganese-exposed developing rats. Arch Toxicol 2013; 87:1231-1244.

Martinez-Finley E, Gavin CE, Aschner M, Gunter TE. Manganese neurotoxicity and the role of reactive oxygen species. Free Rad Biol Med 2013; 62:65-75.

Sidoryk-Wegrzynowicz M, Aschner M. Role of astrocytes in manganese mediated neurotoxicity. BMC Pharmacol Toxicol 2013; 14:23. doi: 10.1186/2050-6511-14-23.

Martinez-Finley E, Chakraborty S, Slaughter JC, Aschner M. Early-Life Exposure to Methylmercury in Wildtype and pdr-1/parkin Knockout C. elegans. Neurochem Res 2013; 38:1543-1552.

Caito SW, Zhang Y, Aschner M. Involvement of AAT transporters in methylmercury toxicity in Caenorhabditis elegans. Biochem Biophys Res Commun 2013; 435:546-550.

Chen P, Martinez-Finley, Bornhorst J, Sudipta Chakraborty, Aschner M. Metal-induced neurodegeneration in C. elegans. Front Aging Neurosc 2013; doi: 10.3389/fnagi.2013.00018, 123-132.

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JOURNAL ARTICLES Zimmermann LT, dos Santos DB, Dórea JG, Barbosa F Jr, Aschner M, Rocha JBT, Farina M. Comparative study on methyl- and ethylmercury-induced toxicity in glioma C6 cells and the potential role of LAT-1 in mediating mercurial-thiol complexes uptake. Neurotoxicology 2013; 38:1-8.

Andrade V, Mateus ML, Batoréu MC, Aschner M, Marreilha dos Santos AP. Urinary -ALA: a potential biomarker of exposure and neurotoxic effect in rats co-treated with a mixture of lead, and manganese. Neurotoxicology 2013; 38:33-41.

Karki P, Lee E, Michael Aschner M. Manganese neurotoxicity: a focus on glutamate transporters. Ann Occup Environ Med 2013; 25:4. doi:10.1186/2052-4374-25-4.

Caito S, Yu Y, Aschner M. Differential response to acrylonitrile toxicity in rat primary astrocytes and microglia. Neurotoxicology 2013; 37:93-9.

Zhang JB, Cai TJ, Aschner M, Zhao F, Yao T, Chen YM, Chen JY, Luo WJ. The Role of Autophagy Dysregulation in Manganese-Induced Dopaminergic Neurodegeneration. Neurotox Res 2013; 24:478- 490.

Karki P, Webb A, Smith K, Lee K, Son D-S, Aschner M, Lee E. CREB and NF- mediate GLT-1 expression in rat astrocytes. J Biol Chem 2013; 288:28975-28986.

Aschner M. Editorial, Foreward to the Issue of Neuropharmacology and Neurotoxicity. J Clin Toxicol 2013; S6:e001. doi: 10.4172/2161-0495.S6-e001.

Martinez-Finley EJ, Caito S, Slaughter JC, Aschner M. The role of skn-1 in methylmercury-induced latent dopaminergic neurodegeneration. Neurochem Res 2013; 38:2650-2660.

Charkrobaty S, Bornhorst J, Nguyen TT, Aschner M. Oxidative stress mechanisms underlying neurodegeneration in C. elegans. Int J Molecular Sci 2013; 14:23,103-23,128. doi:10.3390/ijms141123103.

Caito S, Valentine WM, Aschner M. Dopaminergic neurotoxicity of ethyl N,N-di-n-propylthiocarbamate (EPTC), molinate, and S-methyl-N,N-diethylthiocarbamate (DETC) in Caenorhabditis elegans. J Neurochem 2013; 126:837–851.

Peres TV, Pedro DZ, de Cordova FM, Lopes MW, Gonçalves FM, Nedel N, Walz R, Farina M, Aschner M, and Leal RB. In vitro manganese exposure disrupts MAPK signaling pathways in striatal and hippocampal slices from immature rats. Biomed Res Internat 2013; doi:10.1155/2013/769295.

Santos D, Batoreu MC, Almeida I, Davis RL, Mateus L, Ramos R, Torres E, Aschner M, Marreilha dos Santos AP. Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese. Toxicology 2013; 314; 95-99.

Dalla Corte CL, Wagner C, Sudati JH, Comparsi B, Leite GO, Busanello A, Soares FAA, Aschner M, Rocha JBT. Diphenyl diselenide increases methylmercury-induced neurotoxicity in rats. Biomed Res Internat 2013; 2013:983821, doi.org/10.1155/2013/983821.

Avila DS, Puntel RL, Aschner M. Manganese in Health and Disease. Met Ions Life Sci 2013; 13:199- 227.

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JOURNAL ARTICLES 2014 Wollenhaupt SGN, Soares AT, Salgueiro WG, Noremberg S, Bohrer D, Gubert P, Soares FA, Lüdtke DS, Santos FW, Denardin CC, Aschner M, Avila DS. Seleno- and Telluro-Xylofuranosides attenuate Mn-induced toxicity in C. elegans via the DAF-16/FOXO pathway. Food Chem Toxicol 2014; Feb;64C:192-199. doi: 10.1016/j.fct.2013.11.030.

Dikalova A, Fagiana A, Aschner M, Summar M, Zhang Y, Aschner JL, Fike CD. Sodium-coupled neutral amino acid transporter 1 (SNAT1) modulates L-citrulline transport and nitric oxide (NO) signaling in pulmonary arterial endothelial cells from newborn piglets. PLos One 2013; e85730. doi: 10.1371/journal.pone.0085730.

López-Granero C, Cardona D, Giménez E, Lozano R, Barril J, Aschner M, Sánchez-Santed F, Cañadas F. Comparative study on short- and long-term behavioral consequences of organophosphate exposure: Relationship to AChE mRNA expression. Neurotoxicology 2013; 40:57-64.

Connor JR, Aschner M. Chesselet M-F, Earley CJ, Mignot EJ, Trenkwalder C, Stiasny-Kolster K, Uhl G. Letter to the Editor. Bad Medicine: Restless Leg Syndrome. Spence. Brit Med J 2014; 347:f7615.

Karlsson JOG, Jynge P, Aschner JL, Aschner M. e-letter: The therapeutic and neurotoxic potential of mangafodipir in oxaliplatin-induced neuropathy. J Clin Invest 2014; 124:262–272. doi:10.1172/JCI68730; http://www.jci.org/eletters/view/68730#sec1.

Bornhorst J, Chakraborty S, Meyer S, Lohren H, Brinkhaus S, Knight AL, Caldwell KA, Caldwell GA, Karst U, Schwerdtle T, Bowman AB, Aschner M. The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans. Metallomics 2014; 6:476-490.

Silva Santos V, Bisen-Hersh E, Yu Y, Cabral ISR, Nardini V, Culbreth M, Rocha JBT, Barbosa F Jr, Aschner M. Anthocyanin-rich açaí (Euterpe oleracea Mart.) extract attenuates manganese-induced oxidative stress in rat primary astrocyte cultures. J Toxicol Environ Health 2014; Part A, 77:390–404.

Große Brinkhaus S, Bornhorst J, Chakraborty S, Wehe CA, Niehaus R, Reifschneider O, Aschner M, Karst U. Elemental bio-imaging of manganese uptake in C. elegans. Metallomics 2013; 6:617-21.

Karki P, Webb A, Smith K, Johnson J Jr, Son D-S, Aschner M and Lee E. Yin Yang 1 is a critical repressor of EAAT2 and it mediates manganese-induced impairment of EAAT2 in astrocytes. Mol Cell Biol 2013; 34:1280-1289.

Bowman AB, Aschner M. Considerations on manganese (Mn) treatments for in vitro studies. Neurotoxicology 2014; 41:141-142.

Bisen-Hersh EB, Farina M, Rocha JBT, Barbosa F Jr, Aschner M. Behavioral Effects of Developmental methylmercury drinking water exposure in rodents. J Trace Elem Biol Med 2014; 28:117-124.

Bowman AB, Kwakye GF, Herrero Hernández E, Aschner M. Die Rolle von Mangan bei neurodegenerativen Erkrankungen. Perspect Med 2014; 2:91-108.

Exil V, Ping P, Yu Y, Chakraborty S, Caito SW, Wells SK, Aschner M. Activation of MAPK and FoxO deactivation with manganese exposure in rat neonatal primary astrocytes. PLos One 2014; 9(5):e94753. doi: 10.1371/journal.pone.0094753.

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JOURNAL ARTICLES Martinez-Finley EJ, Aschner M. Recent advances in mercury research. Navas-Acien A, Barchowsky A, ed. Curr Environ Health Reports 2014; 1:163–171.

Andrade V, Mateus ML, Aschner M, Batoreu MC, Marreilha dos Santos, AP. Arsenic and manganese alter lead deposition in the rat. Biol Trace Elem Res 2014; 158:384-391.

Caito S, Zeng H, Aschner J, Aschner M. Methylmercury alters the activities of Hsp90 client proteins, prostaglandin E synthase/p23 (PGES/23) and nNOS. PLos One 2014; 9(5):e98161. doi: 10.1371/journal.pone.0098161.

Caito S, Wu Y. Aschner M. Acrylontrile Differential inflammatory response to acrylonitrile in rat primary astrocytes and microglia. Neurotoxicology 2013; 42:1-7.

Aschner M. Editors Interview. J Clin Toxicol 2014; http://omicsonline.org/clinical-toxicology-open- access-editors-interviews.php.

von Tobel JS, Antinori P, Zurich MG, Rosset R, Aschner M, Gluck F, Scherl A, Monnet-Tschudi F. Repeated exposure to Ochratoxin A generates a neuroinflammatory response, characterized by neurodegenerative M1 microglial phenotype. Neurotoxicology 2014; 44: 61-70.

Santos D, Batoreu C, Mateus L, Aschner M, Santos, AP. Manganese in human parenteral nutrition: Considerations on toxicity and biomonitoring. Neurotoxicology 2013; 43:36-45.

Leyva-Illades D, Chen P, Zogzas CE, Swaim CD, Bowman AB, Mukhopadhyay S, Aschner M. Mutations in SLC30A10 block its intracellular trafficking and manganese efflux activity to cause a hereditary parkinsonian disorder. J Neurosci 2014; 34:14079-14095.

Chen P, Parmalee N, Aschner M. The neurotoxicity of manganese supports Mn as an environmental factor of Parkinson’s disease. Front Toxicogenom 2014; 5:265. doi: 10.3389/fgene.2014.

Kumar KK, Lowe EW, Aboud AA, Neely MD, Odak M, Meiler M, Aschner M, Bowman AB. Cellular manganese content is developmentally regulated in human dopaminergic neurons. Sci Reports 2014; 4:6801 | DOI: 10.1038/srep06801.

Nguyen TT, Aschner M. F3-Isoprostanes as a measure of in vivo oxidative damage in Caenorhabditis elegans. Curr Protocol Toxicol 2014; 62:11.17.1-11.17.13. doi: 10.1002/0471140856.tx1117s62.

Ophir A, Karakis I, Richter ED, Abarbanel JM, Wormser U, Aschner M, Finkelstein Y. An uncommon pattern of polyneuropathy induced by lifetime exposures to drift containing organophosphate pesticides. Neurotoxicology 2014; 45:138-146.

Su P, Zhao F, Zhao F, Aschner M, Chen J, Luo W. The interaction between microglia and neural stem/percursor cells. Brain Res Bull 2014; 09C:32-38.

Andrade V, Mateus ML, Batoréu MC, Aschner M, Marreilha dos Santos AP. Changes in rat urinary porphyrins profile predict the magnitude of the neurotoxic effects induced by a mixture of lead (Pb), arsenic (As) and manganese (Mn). Neurotoxicology 2014; 45:168-77.

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JOURNAL ARTICLES Vorhees CV, Graham DL, Amos-Kroohs RM, Braun AA, Grace CE, Schaefer TL, Skelton MR, Erikson KM, Aschner M, Williams MT. Effects of developmental manganese, stress, and the combination of both on monoamines, growth, and corticosterone. Toxicol Reports 2014; 1:1046-1061.

Yuntao F, Chenjia G, Panpan Z, Wenjun Z, Suhua W, Guangwei X, Haifeng S, Jian L, Wanxin P, Yun F, Cai J, Aschner M, Rongzhu L. Role of autophagy in methylmercury-induced neurotoxicity in primary rat astrocytes. Arch Toxicol 2014; DOI 10.1007/s00204-014-1425-1.

2015 Chen P, DeWitt M, Bornhost J, Soares FA, Mukhopadhyay S, Bowman AB, Aschner M. C. elegans DJ- 1 homolgue alters survival, and dopamine-dependent lifespan and dauer behavior after toxic Mn exposure in a DAF-16 dependent manner. Metallomics 2015; 7:289 - 298.

Kumar KK, Goodwin CD, Aschner M, McLean JA, Bowman AB. Untargeted metabolomics in Huntington’s disease striatal cell model shows disease-dependent and disease-manganese interactions in metabolic pathways. Metallomics 2015; 11;7:363-370.

Karki P, Smith K, Johnson J Jr, Aschner M, Lee EY. Genetic dysregulation of astrocytic glutamate transporters and its implications in neurological disorders and manganese toxicity: Emphasis on EAAT2. Neurochem Res 2015; 40:380-388.

Tidball AM, Bryan MR, Uhouse MA, Kumar KK, Aboud AA, Feist JE, Ess KC, Neely MD, Aschner M, Bowman AB. A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington’s disease. Human Mol Genet 2015; 24:1929-44.

Samuelson LE, Scherer RL, VanSaun MN, Fan K-H, Dozier EA, Carter KJ, Koyama T, Shyr Y, Aschner M, Stanwood GD, Bornhop DJ, Matrisian LM, McIntyre JO. NanoDendrons targeting drug delivery to the tumor microenvironment have reduced systemic neurotoxicity. Neurotoxicology 2015; 47:88-98.

Chen P, Chakraborty S, Peres TV, Bowman AB, Aschner M. Manganese-induced neurotoxicity: from C. elegans to Humans. Toxicol Res 2015; 4:191-202.

Chakraborty S, Chen P, Bornhorst J, Schwerdtle T, Schumacher T, Kleuser B, Bowman AB, Aschner M. Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans. Metallomics 2015; 7:847-856.

Jering K, Aschner M, Beller A, Hamm EL, Langdon M, Maitre NL. Parenteral nutrition as an unexpected and preventable source of Hg exposure in preterm infants. Pediatrics 2015; 166:1533-1535.

Su P, Zhao F, Aschner M, Cao Z, Wang D, Chen J, Luo W. Mir-203-mediated tricellulin mediates lead- induced in vitro loss of blood-cerebrospinal fluid barrier (BCB) function. In Vitro Toxicol 2015; 29:1185- 1194.

Andrade V, Mateus ML, Batoréu MC, Aschner M, Marreilha dos Santos AP. Lead, arsenic and manganese metal mixture exposures: focus on biomarkers of effect. Biol Trace Elem Res 2015; 166:13-23.

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JOURNAL ARTICLES Kwakye G, Paoliello MMB, Mukhopadhyay S, Bowman AB, Aschner M. Manganese-induced Parkinsonism and Parkinson’s disease: Shared and distinguishable features. Int J Environ Res Public Health 2015; 12:7519-40.

Crone B, Aschner M, Schwerdtle T, Karst U, Bornhorst L. Elemental bioimaging of Cisplatin in Caenorhabditis elegans by LA-ICP-MS. Metallomics 2015; 7:1189-95. Horning KJ, Caito SW, Tipps KG, Bowman ABB, Aschner M. Manganese is essential for neuronal health. Ann Rev Nutrit 2015; 35:71-108.

Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello MMB, Bowman AB, Aschner M. Manganese homeostasis: Transport, trafficking and neurotransmitter modulation. J Neurochem 2015; 134:601-610.

Parmalee NL, Ye Y, Calder B, Maqbool SB, Bowman AB, Aschner M. RNA-seq in C. elegans following manganese exposure. Curr Protocol Toxicol 2015; 65:11.20.1-11.20.17. doi: 10.1002/0471140856. tx1120s65.

Peres TV, Eyng H, Lopes SC, Colle D, Gonçalves FM, Venske DKR, Costa AP, Lopes MW, Ben J, Bornhorst J, Aschner M, Farina M, Prediger RDS, Leal RB. Developmental exposure to manganese induces lasting motor and cognitive impairment in rats. Neurotoxicology 2015; 50:28-37.

Stefanello ST, Gubert P, Puntel B, Mizdal CR, de Campos MMA, Bender C, Dornelles L, Avila DS, Aschner M, Soares FAA. Protective effects of novel organic selenium compounds against oxidative stress in the nematode, Caenorhabditis elegans. Toxicol Reports 2015; 2:961–967.

Caito S, Aschner M. Unit 6.18: Glutathione measurements in C. elegans. Curr Protocols Toxicol 2015; 64(618):6.18.1-6.18.6.

Bixel MG, Fretham SJB, Aschner M. Unit 11.19: High-resolution multi-photon imaging of morphological structures of caenorhabditis elegans. Curr Protocols Toxicol 2015; 64(1119):11.19.1-11.19.11.

Karki P, Smith K, Johnson J Jr, Aschner M, Lee E. Role of astrocytic glutamate transporters in manganese-induced neurotoxicity. Neurochem Internat 2015; 88:53-9.

Dimovasili C, Aschner M, Zaganas I, Plaitakis A. hGDH1 and hGDH2 display differential inhibition by manganese: implications for metabolism and toxicity. Neurochem Internat 2015; 88:60-5.

Caito S, Aschner M. Mitochondrial redox dysfunction and environmental exposures. Special issue on Mitochondrial Stress in Disease. Antioxidants and Redox Signaling 2015; 23:578-95.

Chen P, Bowman AB, Mukhopadhyay S, Aschner M. SLC30A10: a novel manganese transporter. Worm 2015; DOI: 10.1080/21624054.2015.1042648.

Schumacher F, Chakraborty S, Kleuser B, Gulbins E, Schwerdtle T, Aschner M, Bornhorst J. Highly sensitive determination of dopamine and serotonin in Caenorhabditis elegans using isotope-dilution liquid chromatography-electrospray ionization-tandem mass spectrometry. Talanta 2015; 144:71-79.

Karki P, Smith K, Son D-S, Aschner M, Lee E. Transcriptional regulation of the astrocytic excitatory amino acid transporter 1 (EAAT1) via NF-κB and Yin Yang 1 (YY1). J Biol Chem 2015; 290:23725- 23737.

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JOURNAL ARTICLES Caito S, Aschner M. Neurotoxicity of Metals. Handb Clin Neurol. 2015;131:169-89.

Roberts R, Paule, MG, O’Callaghan J, Miller D, Moser V, Calligaro D, Slikker W Jr, Jeromin, A, Kallman MJ, Lynch JJ, Morris CM, Herr D, Hudzik T, Aschner M. Translational Biomarkers of Neurotoxicity: the Way Forward? Toxicol Sci 2015; 148:332-340.

Aschner JL, Slaughter JC, Aschner M, Steele S, Beller A, Mouvery A, Furlong H, Anderson A, Maitre NL. Neuroimaging correlates of manganese (Mn) exposure in infants receiving parenteral nutrition. Am J Clin Nutrit 2015; 102:1482-1489.

Yu B, Changsheng Y, Wenjun Z, Ben L, Hai Q, Jing M, Guangwei X, Shuhua W, Fang L, Aschner M, Rongzhu L. Differential protection of pre- versus post-treatment with curcumin, Trolox, and N- acetylcysteine against acrylonitrile-induced cytotoxicity in primary rat astrocytes. Neurotoxicology 2015; 51:58-66.

2016 Reckziegel P, Chen P, Fachinetto R, Aschner M. Extracellular dopamine and alterations on dopamine transporter are related to reserpine toxicity in Caenorhabditis elegans. Arch Toxicol 2015; Arch Toxicol. 2016; 90:633-645.

Yeter D, Portman MA, Aschner M, Farina M, Chan WC, Hsieh KS, Kuo HC. Ethnic Kawasaki Disease Risk Associated with Blood Mercury and Cadmium in U.S. Children. Int J Environ Res Public Health. 2016; 13(1). pii: E101. doi: 10.3390/ijerph13010101.

Lee KH, Aschner M. A Simple Light Stimulation of Caenorhabditis elegans. Curr Protocol Toxicol 2016; 1;67:11.21.1-11.21.5. doi: 10.1002/0471140856.tx1121s67.

Su P, Zhang J, Wang D, Hu M, Zhao F, Cao Z, Aschner M, Luo W. The role of autophagy in modulation of neuroinflammation in microglia. Neuroscience 2016; 319:155-67.

Zhang Z, Miah M, Culbreth M, Aschner M. Autophagy in neurodegenerative diseases and metal neurotoxicity. Neurochem Res 2016; 41:409-422.

Adedara IA, Rosemberg DB, Souza DO, Farombi EO, Aschner M, Rocha JBT. Neuroprotection of luteolin against methylmercury-induced toxicity in lobster cockroach Nauphoeta cinerea. Environ Toxicol Pharmacol 2016; 42:243-251.

Tidball AM, Neely MD, Chamberlin R, Aboud AA, Kumar KK, Han B, Aschner M, Ess KC, Bowman AB. Genomic instability in the generation of Huntington’s disease human induced pluripotent stem cells. PLos One 2015; 11(3):e0150372. doi: 10.1371/journal.pone.0150372.

Fagundez D, Freitas Câmara D, Salgueiro WG, Noremberg S, Puntel R, Escobar Piccoli J, Garcia SC, Rocha JBT, Aschner M, Ávila DS. Behavioral and dopaminergic damage induced by acute iron toxicity in Caenorhabditis elegans. Toxicology Res 2015; 4, 878-884.

Adedara IA, Rosemberg DB, Souza DO, Kamdem JP, Farombi EO, Aschner M, Rocha JBT. Neurobehavioral and biochemical alterations in lobster cockroach Nauphoeta cinerea exposed to methylmercury. Toxicol Res 2015; 4, 442-451.

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JOURNAL ARTICLES López-Granero C, Ruiz-Muñoz AM, Nieto-Escamez FA, Colomina MT, Aschner M, Sanchez-Santed F. Chronic dietary chlorpyrifos causes memory impairment and thigmotaxic behavior: Implication of the Dizocilpine and Diazepam. Neurotoxicology 2016; 53:85-92.

Su P, Zhang J, Wang S, Cai T, Aschner M, Cao Z, Zhao F, Wang D, Wang X, Chen J, Luo W. Genistein alleviates lead-induced neurotoxicity in vitro and in vivo: Involvement of multiple signaling pathways. Neurotoxicology 2015; 53:153-164.

Song H, Zheng G, Liu Y, Shen XF, Zhao ZH, Aschner M, Luo WJ, Chen JY. Cellular Uptake of lead in the blood-cerebrospinal fluid barrier: Novel roles of connexin 43 hemichannel and its down-regulations via Erk phosphorylation. Toxicol Appl Pharmacol 2016; 297:1-11.

Chen P, Miah MR, Aschner M. Metals and neurodegeneration. F1000 2016; 5. pii: F1000 Faculty Rev- 366. doi: 10.12688/f1000research.7431.1.

Kraft AD, Aschner M, Cory-Slechta DA, Bilbo SD, Caudle WM, Makris SL. Unmasking silent neurotoxicity following developmental exposure to environmental toxicants. Neurotoxicol Teratol 2016; 55:38-44.

Adedara IA, Rosemberg DB, de Souza D, Farombi EO, Aschner M, Souza DO, Rocha JBT. Neurobehavioral and biochemical changes in Nauphoeta cinerea following dietary exposure to chlorpyrifos. Pestic Biochem Physiol 2016; 130:22-30. doi: 10.1016/j.pestbp.2015.12.004.

Gubert P, Puntel P, Lehmen T, Bornhorst J, Avila DS, Aschner M, Soares FAA. Reversible reprotoxic effects of manganese through DAF-16 transcription factor activation and vitellogenin downregulation in Caenorghabditis elegans. Life Sci 2016; 151:218-223.

Pinkas A, Aschner M. Advanced glycation end-products and their receptors: related pathologies, recent therapeutic strategies and a potential model for future neurodegeneration studies. Chem Res Toxicol 2016; 29:707-714.

Caito S, Aschner M. NAD+ supplementation attenuates methylmercury dopaminergic and mitochondrial toxicity in Caenorhabditis elegans. Toxicol Sci 2015; 151:139-149.

Peres TV, Ong LK, Eyng H, Costa AP, Venske DKR, Colle D, Gonçalves FM, Lopes MW, Farina M, Dickson PW, Dunkley PR, Aschner M, Leal RB. Tyrosine Hydroxylase Regulation in Adult Rat Striatum following Short-term Neonatal Exposure to Manganese. Metallomics 2016; 8:597-604.

Chen P, Culbreth M, Aschner M. Exposure, epidemiology, and mechanism of the environmental toxicant manganese. Environ Sci Pollution Res 2016; 23, 13802-13810.

Yu B, Wenjun Z, Changsheng Y, Yuntao F, Jing M, Ben L, Hai Q, Guangwei X, Suhua W, Fang L, Aschner M, Rongzhu L. Preconditioning of endoplasmic reticulum stress protects against acrylonitrile- induced neurotoxicity in primary rat astrocytes: the role of autophagy. Neurotoxicology 2016; 55:112-21.

Zhang Z, Singh R, Aschner M. Methods for the detection of autophagy in mammalian cells. Curr Protocols Toxicol 2016; 69:20.12.1-20.12.26. doi: 10.1002/cptx.11.

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JOURNAL ARTICLES Zogzas CE, Aschner M, Mukhopadhyay S. Functional analyses of the manganese efflux activity of SLC30A10. J Biol Chem 2016; 291:15,940-15,957.

Peres T, Martinez-Finley EJ, Parmalee N, Aschner M. Untangling the manganese-α-synuclein web. Frontiers Neurosci 2016; 10:364. doi: 10.3389/fnins.2016.00364.

Avila DS, Benedetto A, Au C, Bornhorst J, Aschner M. Involvement of Heat Shock Proteins on Mn- induced toxicity in Caenorhabditis elegans. BMC Pharmacol Toxicol 2016; 17:57.

Peres TV, Schettinger MRC, Ávila DS, Chen P, Carvalho F, Aschner M. Manganese-induced neurotoxicity, behavioral consequences and neuroprotective strategies. BMC Pharmacol Toxicol 2016; 17:57.

Antunes dos Santos A, Appel Hort M, Culbreth M, López-Granero C, Farina M, Rocha JB, Aschner M, Methylmercury and brain development: A review of recent literature. J Trace Elem Med Biol 2016; 8:99- 107. doi: 10.1016/j.jtemb.2016.03.001..

Parmalee N, Aschner M. Manganese and aging. Neurotoxicology 2016; 56:262-268.

Ruszkiewicz JA, Bowman AB, Farina M, Rocha JBT, Aschner M. Sex-and structure-specific differences in antioxidant responses to methylmercury during early development. Neurotoxicology 2016; 56:118- 126.

Aschner M, Ceccatelli S, Daneshian M, Fritsche E, Hasiwa N, Hartung T, Hogberg H, Leist M, Li A, Mundy WR, Padilla S, Piersma AH, Bal-Price A, Seiler A, Westerink R, Zimmer B, Lein P. Selection of reference compounds for characterization and development of alternative methods for developmental neurotoxicity (DNT) testing. ALTEX 2016; doi: 10.14573/altex.1604201.

Nguyen T, Fessel JP, Caito SW, West JD, Zhu S, Aschner M, Roberts LJ II. Scavengers of reactive γ- ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7. Aging 2016; 8:1759-1780.

Henze A, Homann T, Rohn I, Aschner M, Link C, Kleuser B, Schweigert FJ, Schwerdtle T, Bornhorst J. Caenorhabditis elegans as a model system to study post-translational modifications of transthyretin. Sci Reports 2016; 6:37346. doi: 10.1038/srep37346.

Culbreth M, Aschner M. Toxicological aspects of methylmercury exposure. Adv Neurobiol 2016; 13:295-305.

Ijomone OM, Miah MR, Peres TV, Aschner M. Mutants for trt-1, the catalytic subunit of telomerase in Caenorhabditis elegans, are less sensitive to Mn-induced toxicity and DAergic degeneration. Neurotoxicology 2016; 57:54-60.

Aschner M, Autrup HN, Berry SC, Boobis AR, Cohen SM, Creppy EE, Dekant W, Doull J, Galli CL, Goodman JI, Gori GB, Greim HA, Joudrier P, Kaminski NE, Klaassen CD, Klaunig JE, Lotti M, Marquardt HW, Pelkonen O, Sipes IG, Wallace KB, Yamazaki H. Upholding science in health, safety and environmental risk assessments and regulations. Toxicology 2016; 371:12-16.

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JOURNAL ARTICLES Aschner M, Miller G. A Golden Anniversary for the National Institute of Environmental Health Sciences (NIEHS). SOT/NIEHS 50th Anniversary. Toxicol Sci 2016; 54:200-201.

2017 Pinkas A, Aschner M. AGEs/RAGE-related neurodegeneration: daf-16 as a mediator, insulin as an ameliorant and C. elegans as an expedient research model. Chem Res Toxicol 2017; Chem Res Toxicol 30:38-42.

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National Academy of Sciences Reports: 2000 Bull RJ, Aschner M, Brewer GH, Harris ED, Keen CL, Kelsey KT, Sunderman FW, Tsuji JS, Zeise LA. Copper in Drinking Water, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council, National Academy of Sciences, Washington, DC: National Academy Press, 2000, 1-147.

Sox HC, Jr, Aschner M, Buffler PA, Costa LG, Krupnick JL, Lowndes H, Mazzaferri EL, Moschandreas DJ, Phelps CE, Potolocchio SJ, Regal JF, Schenker M, Schur PH, Seillier-Moiseiwitsch F, Willett WC, Zeger SL. Health Effects Associated With Exposures Experienced During The Gulf War, Institute of Medicine, National Academy of Sciences, Division Of Health Promotion and Disease Prevention, Washington, DC: National Academy Press, 2000, 1-328.

Sox HC, Jr, Aschner M, Buffler PA, Costa LG, Krupnick JL, Lowndes H, Mazzaferri EL, Moschandreas DJ, Phelps CE, Potolocchio SJ, Regal JF, Schenker M, Schur PH, Seillier-Moiseiwitsch F, Willett WC, Zeger SL. Safety of the anthrax vaccine: A letter report. Committee on Health Effects Associated With Exposures During The Gulf War, Institute of Medicine, National Academy of Sciences, Division Of Health Promotion and Disease Prevention, 2000, 1-8.

2001 Hobbs C, Aschner M, Bellinger D, Buck G, DuBois AB, Hall AH, Johannsen F, Moore D, Tsuji J. Submarine Evacuation Action Levels (SEAL), Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council, National Academy of Sciences, Washington, DC: National Academy Press, 2001; 1-260.

2008 Howell DG, Aschner M, Begg MD, Borges HT, Chen VW, Feldman HI, Harber P, Heagerty P, Lee K, Links J. Gulf War and Health: Updated Literature Review of Depleted Uranium. Institute of Medicine, National Academy of Sciences, Division of Health Promotion and Disease Prevention, Washington, DC: National Academy Press, 2008; 1-234.

2008 Howell DG, Aschner M, Begg MD, Chen VW, Feldman HI, Harber P, Heagerty P, Lee K, Links J. Gulf War and Health: Epidemiologic Studies of Veterans Exposed to Depleted Uranium: Feasibility and Design Issues. Institute of Medicine, National Academy of Sciences, Division of Health Promotion and Disease Prevention, Washington, DC: National Academy Press, 2008; 1-43.

OTHER REPORTS: 2001 Aschner M, Dorman DC, Manganese: Research Needs. Prepared for the International Manganese Institute, Paris, and the Ferroalloys Association, Washington DC, October 5, 2001.

2002 Aschner M, Dorman DC. Review of Manganese Toxicokinetics. Health Canada, Air Quality and Health Division, Ottawa, ON, Canada, August 1, 2002.

2008 Egyed M, Willey J, Walker M, Williams A, Wood G, Aschner M, Dorman D. Health Canada Risk Assessment for Inhaled Manganese. Health Canada, Air Quality and Health Division, Ottawa, ON, Canada, March 2008. http://www.hc-sc.gc.ca/ewh-semt/alt_formats/hecs-sesc/pdf/air/out- ext/consult/draft_ebauche/manganese_e.pdf.

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1985 Department of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY, June 1985.

Review of Current Concepts in Methylmercury Toxicity with Major Emphasis on its Effects on the Protein Synthetic Machinery and Axonal Transport. “Jozef Stefan” Institute, Ljublijana, Yugoslavia, November 1985.

1986 Mechanisms of Methylmercury Brain Uptake and Axonal Transport. Department of Pharmacology, Hebrew University, Jerusalem, Israel, November 13, 1986.

Effects of Methylmercury on Axonal Transport and CNS Methylmercury Uptake Mechanisms. Department of Pharmacology and Toxicology, Albany Medical College, Albany, NY, November 26, 1986.

1989 Methylmercury Uptake across the Blood-Brain Barrier. Hudson-Berkshire Chapter of the Society of Neuroscience, Albany, NY, January 30, 1989.

Methylmercury Uptake and Influx in Primary Astrocyte Cultures. Division of Neurosurgery, Albany Medical College, Albany NY, April 5, 1989.

Mechanisms of Methylmercury-Induced CNS Injury: Role of Neutral Amino Acids. BRSG Lecture Series, Albany Medical College, Albany, NY, September 13, 1989.

1990 Advances in Toxicology and the Implications for Pediatricians. Pediatric Grand Rounds, Albany Medical College, Albany, NY, May 23, 1990.

The Use of Astrocytes in Culture as Model Systems for Evaluating Neurotoxic-Induced-Injury. Eighth International Neurotoxicology Conference, Little Rock, AR, October 4, 1990.

Mercury Toxicity. N.Y. State Department of Health, School of Public Health, Albany, NY, November 1, 1990.

1991 Manganese Transport across the Blood-Brain Barrier, Conference on Research Needs to Assess the Health Risks of Manganese, co-sponsored by the U.S. EPA and NIEHS, Research Triangle Park, NC. March 12-15, 1991.

Advances in Pharmacology and Toxicology and the Implications for Pediatricians. Pediatric Teaching Week, “Towards the Year 2000 - A Pediatric Update”, Cordoba, Argentina, April 12, 1991.

Astrocytes: A Possible Link to Methylmercury Neurotoxicity. International Association of Great Lakes Research, Buffalo, NY, June 4, 1991.

The Role of L-Cysteine in Methylmercury Transport in Astrocytes. Second International Congress on Amino Acids and Analogues, Vienna, Austria, August 9, 1991.

1992 The Role of Astrocytes in Metal Neurotoxicity, Immunology Research Meetings, Albany Medical College, Albany, NY, September 22, 1992.

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The Role of Astrocytes in Metal Neurotoxicity, Institute of Environmental Medicine, New York University Medical Center, Tuxedo Park, NY, October 14, 1992

1993 Lead Exposure in the Pediatric Population: Status Report, Pediatric Journal Club, Department of Pediatrics, Albany Medical College, Albany, NY, January 28, 1993.

Blood-Brain Barrier: Mn (II) and Iron Homeostasis. Workshop on Trace Metal Ions in the CNS: Dynamics and Regulation. American Society for Neurochemistry, Richmond, VA, March 24, 1993.

Effects of Heavy Metals on Astrocytic Homeostasis: Correlation with -SH Reagents. Symposium: ”The Role of Glia in CNS Pathology and Repair: Basic and Clinical Aspects”. Polish Academy of Sciences, Warsaw, Poland, June 14, 1993.

Mercurial- and -SH-Induced Alterations in Glutamate Homeostasis. Symposium: “Heavy Metal-Induced Alterations in Excitable Membranes”. International Biophysics Satellite Congress, Tihany, Hungary, July 22-24, 1993.

Heavy Metal-Induced Neurotoxicity, Departments of Biochemistry and Molecular Biology, and Medicine Seminar Series, Albany Medical College, Albany, NY, November 8, 1993.

1994 The Role of Astrocytes in Mercury Neurotoxicity. Department of Physiology and Pharmacology, Wake Forest University School of Medicine of Wake Forest University, Winston-Salem, NC, January 25, 1994.

-SH Groups and the Release of D-Aspartate and Rubidium from Swollen Astrocytes, Invited Platform Presentation, American Society for Neurochemistry, Albuquerque, NM, March 9, 1994.

The Astrocyte. Continuing Education Course: “In Vitro Neurotoxicology”. Society of Toxicology, Dallas, TX, March 13, 1994.

Does Metallothionein Protect against Mercury Neurotoxicity? Hudson-Berkshire Chapter of the Society of Neuroscience, Albany, NY, April 4, 1994.

Astrocytes as a Target Site for Neurotoxicity. In: Alternatives in the Assessment of Toxicity: Theory and Practice. Aberdeen Proving Ground, MD, May 26, 1994.

Manganese Homeostasis in the CNS, Workshop on the Bioavailability and Oral Toxicity of Manganese, sponsored by the EPA, Omni Netherlands Plaza, Cincinnati, OH, August 30-31, 1994.

Metallothionein Attenuates Methylmercury Toxicity in Astrocytes. In: Neurotoxicity of Mercury: Indicators and Effects of Low Level Exposure. Twelfth International Neurotoxicology Conference, Hot Springs, AR, October 30 - November 2, 1994.

1995 Cadmium Chloride-Induced Metallothionein Expression in Neonatal Rat Primary Astrocyte Cultures, Poster-Discussion Session, Society of Toxicology Meeting, Baltimore, MD, March 11, 1995.

Methylmercury in Astrocytes - What Possible Significance? US Environmental Protection Agency (EPA), Research Triangle Park, NC, May 18, 1995.

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Careers in Science; Forbush Elementary School; East Bend, NC; Research! NC Speakers Bureau, Target Health, May 24, 1995.

Astrocyte: Biochemical and Pathophysiologic Perspectives, Glial Club, Wake Forest University School of Medicine, Winston-Salem, NC, June 5, 1995.

Astrocytes as Modulators of Mercury-Induced Neurotoxicity. In: The Role of Glia in Neurotoxicity, Fifth Meeting of the International Neurotoxicology Association (INA), Port Ludlow, WA, June 27, 1995.

1996 Do Astrocytes Mediate Developmental Neurotoxicity? Department of Obstetrics/Gynecology, Perinatal Group, Wake Forest University School of Medicine, January 31, 1996.

Astrocytes as Modulators of Neurotoxicity, Department of Biochemistry, Wake Forest University School of Medicine, February 6, 1996.

Heavy Metal- and pH-Induced Metallothionein Expression in Astrocytes. In: Symposium, Brain Metallothioneins: The Role in Physiology and Pathology, Society of Toxicology Meeting, Anaheim, CA, March 11, 1996.

Astrocytes and Metal Toxicity. Tutorial, Neuroscience Program, Wake Forest University School of Medicine, Winston-Salem, NC, March 22, 1996.

Astrocyte Metallothioneins and Their Neuroprotective Role. In: Third International Conference on Neuroprotective Agents: Clinical and Experimental Aspects, Varenna, Lake Como, Italy, September 12, 1996.

Invited Speaker and Discussants to the Kansas Idea Symposium/Work Session, Oxidative Regulation of Gene Expression: Role in Neurodegenerative Diseases, University of Kansas Medical Center, Kansas City, KS, October 10 - 12, 1996.

Glial Modulation of Immune Responses. In: Neuroimmunotoxicology, Fourteenth International Neurotoxicology Conference, Hot Springs, AR, October 13 - 16, 1996.

Current Issues in Manganese Neurotoxicity, Chemical Industry Institute of Toxicology (CIIT), Research Triangle Park, NC, October 29, 1996.

1997 Manganese Homeostasis in the CNS. In: Interactive Panel, How Metals Become Available in the Brain to Induce Oxidative Injury, Winter Conference on Brain Research, Breckenridge, CO, January 28, 1997.

Manganese Neurotoxicity. In: Workshop, Should Manganese be added to Gasoline: Making Rational Public Policy in the Face of Uncertainty. Society of Toxicology Meeting, Cincinnati, OH, March 11, 1997.

Metallothioneins as Neuroprotectants. In: Brain Metallothioneins, Sixth Meeting of the International Neurotoxicology Association (INA), Szeged, Hungary, July 3, 1997.

Manganese. Invited lecture. In: Advanced Training Seminar on Heavy Metal Toxicology: Diagnosis and Treatment, Great Lakes College of Clinical Medicine, Pittsburgh, PA, September 17, 1997.

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Induction of Metallothionein-I (MT-I) mRNA in Primary Astrocyte Cultures is Mediated by Hypotonicity and not Ethanol per se. In: The Fourth International Metallothionein Meeting, Kansas City, MO, September 17 - 20, 1997.

Manganese Distribution in the CNS. In: Manganese Transport and Distribution in the CNS? Fifteenth International Neurotoxicology Conference, Little Rock, AR, October 26, 1997.

1998 Opportunities to Develop Collaborations within North Carolina, In: NC Chapter Society of Research Administrators Conference, Charlotte, NC, March 9, 1998.

In Utero Exposure to Mercury Vapor (Hg0) and Metallothionein Expression in Rat Brain and Astrocyte Cultures. International Academy of Oral Medicine and Toxicology (IAOMT), Durham, NC, March 14, 1998.

Functional Aspects of Astrocytic Metallothioneins. US Environmental Protection Agency (EPA), Research Triangle Park, NC, April 6, 1998.

Glial Function and Modulation of Immune Responses. International Congress of Toxicology (ICT), Paris, France, July 8, 1998.

Metallothioneins Attenuate MeHg-Induced Neurotoxicity in Cultured Astrocytes and Astrocytoma Cells. Fourth International Conference on Neuroprotective Agents, Annapolis, MD, November 16, 1998.

Neurotoxic Mechanisms, Classification. International Graduate School in Neurosciences, University of Tampere, Finland, December 7, 1998.

The Role of Glial Cells in Neurotoxicology. International Graduate School in Neurosciences, University of Tampere, Finland, December 7, 1998.

Neurotoxic Mechanisms of Metals. International Graduate School in Neurosciences, University of Tampere, Finland, December 8, 1998.

Metallothioneins, Metals, and CNS Protection. International Graduate School in Neurosciences, University of Tampere, Finland, December 9, 1998.

1999 Invited Seminar, Metallothioneins and Stress Signaling in Astrocytes, Department of Neuroscience & Anatomy, Penn State University School of Medicine, Hershey PA, February 4, 1999.

Molecular Mimicry of Metals. Advanced Continuing Education Course: “Metals”. Society of Toxicology, New Orleans, LA, March 15, 1999.

Metallothionein and Astrocytic Stress-Response Signaling. In Workshop: Stress-Response Signaling in Glial Cells (Narayan Bhat, Chair), American Society of Neurochemistry, New Orleans, LA, March 16, 1999.

Astrocytes, Metallothioneins and Metals: Relevance to CNS Injury. In: Neuroscience Colloquium, Wake Forest University School of Medicine, Winston-Salem, NC, April 16, 1999.

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Manganese Fuel Additives: an Emerging Threat? In: Environmental Influences on Children: Brain, Development, and Behavior. The New York Academy of Medicine, New York, NY, May 24, 1999.

Manganese in Health and Disease. In: Scientific Advisory Group Meeting, International Manganese Institute, Biarritz, France, June 11, 1999.

Methylmercury and Glutamate Transport in Astrocytes. In: Glutamate-Glutamine Homeostasis in the CNS: Physiological and Pathological Aspects. Wierzba, Poland, June 20, 1999.

Transfection and Overexpression of Metallothionein-I (MT-I) in MT-I/MT-II Knockout (MT-KO) Mice Increases Their Resistance to Methylmercury (MeHg-Induced Cytotoxicity). International Neurotoxicology Association Meeting, Leicester, July 5, 1999.

Induction of Astrocyte Metallothioneins by Zinc Confers Resistance against the Acute Cytotoxic Effects of Methylmercury. In Workshop on “Zinc in Astroglial and Muller Cells: Multiple Physiological Functions”. European Society for Neurochemistry/International Society for Neuroscience, Berlin, August 10, 1999.

Neuronal-Glial Interactions: Molecular Targeting by Developmental Neurotoxins. In: Seventeenth International Neurotoxicology Conference. Little Rock, AR, October 18, 1999.

Metallothionein and Astrocytic Stress-Response Signaling. Invited Seminar, Health Sciences Center, College of Pharmacy, University of Oklahoma, Oklahoma City, OK, November 11, 1999.

Metallothionein and Astrocytic Stress-Response Signaling. Invited Seminar, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, November 18, 1999.

2000 Glial Role in Alcohol-Induced Neurotoxicity upon Acute Alcohol Withdrawal, at The Center for the Neurobehavioral Study of Alcohol at Wake Forest University School of Medicine, Winston-Salem, NC, January 18, 2000.

The Toxicology of Mercury. Invited Seminar, Environmental Health Institute, Oklahoma State University, Stillwater, OK, April 13, 2000.

Mercury Toxicity. Invited Lecture, Mercury Toxicity Workshop, American College for the Advancement in Medicine, Dallas, TX, May 4, 2000.

Neurotoxic Mechanisms of Fish-Borne Methylmercury. Invited Seminar, International Association for Great Lake Research, Cornwall, Ontario, May 24, 2000.

Volume Changes in Primary Astrocyte Cultures Exposed to Ethanol. Fifth International Conference on Neuroprotective Agents, Lake Tahoe, CA, September 18, 2000.

Alcohol and Developmental Neurotoxicity: Effects on Glutamate Transporters. In: Eighteenth International Neurotoxicology Conference. Colorado Springs, CO, September 24, 2000.

Manganese: Reactive Oxygen Species and Bioenergetics. The International Manganese Institute and the Ferroalloys Association Scientific Advisory Groups Meeting. Winston-Salem, NC, October 5, 2000.

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Hot Topics in Manganese and Mercury Neurotoxicity. Invited Seminar, Laboratory for Neurotoxicity Studies, Virginia-Maryland Regional College of Veterinary Medicine. Virginia Tech, Blacksburg, VA, November 28, 2000.

Astrocytic Stress-Response Signaling. Invited Seminar, Program in Neuroscience, Florida State University, Tallahassee, FL, December 6, 2000.

2001 Ethanol Decreases Zinc Transfer to the Fetus in Normal but not Metallothionein-Null Mice. Journal Club presentation, The Center for the Neurobehavioral Study of Alcohol, Wake Forest University School of Medicine, Winston-Salem, NC, January 16, 2001.

Neuropathogenesis of Mercury Toxicity. Microbiology, Immunology and Toxicology of Autism and Other Neurodevelopmental Disorders, the Banbury Center, Cold Spring Harbor Laboratory, NY, February 12, 2001.

Neuronal-Glial Interactions: Molecular Targeting by Methylmercury. Department of Pharmacology, Wright State University, Dayton, OH, March 15, 2001

Disposition-Related Neuronal Responses: Manganese Neurotoxicity from CNS Transport to Molecular Interactions. In: Neurotoxicology of Metals: Causes and Consequences. Basic Continuing Education Course. Society of Toxicology, San Francisco, CA, March 25, 2001.

Electronic Theses and Dissertations (ETDS). General Graduate Faculty meeting, WFU, April 23, 2001. Methylmercury Toxicity Studies in Cell Cultures. In: Brain Energy Metabolism in Neurotransmission: Function and Dysfunction. Trondheim, Norway, May 21, 2001.

Key Note Address. Open Issues from 15th International Conference on Manganese. In: INFACON 9, Quebec City, Canada, June 4, 2001.

The Uptake of Manganese in Brain Endothelial Cultures. In: INFACON 9, Quebec City, Canada, June 4, 2001.

Effects of Manganese on Oxidative-Stress in CATH.a Cells. In: INFACON 9, Quebec City, Canada, June 4, 2001.

Effects of Mn on the Developing Rat Brain: Oxidative-Stress Related Endpoints. INFACON 9, Quebec City, Canada, June 4, 2001.

Needs for Future Research: Manganese and the Nervous System. INFACON 9, Quebec City, Canada, June 5, 2001.

Needs for Future Research: Manganese and the Nervous System. International Neurotoxicology Association, Estoril, Portugal, June 18, 2001.

Neuronal-Glial Interactions: Molecular Targeting by Methylmercury. In: International Neurotoxicology Association, Estoril, June 19, 2001.

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The in vitro Uptake of Manganese (Mn) in Cultured CNS Endothelium and Astrocytes. In: Parkinson’s Disease, Environment and Genes, Nineteenth International Neurotoxicology Conference, Colorado Springs, CO, August 27, 2001.

Manganese: Is it the New Toxic Troublemaker? Metal Binding in Medicine, Chelation Therapy Workshop, International College of Integrative Medicine, Cleveland, OH, October 3, 2001.

US Environmental protection Agency (EPA), Manganese Transport in the CNS: in vivo and in vitro Measurements, Research triangle Park, NC, November 29, 2001.

2002 Perchlorate Environmental Contamination: Toxicological Review and Risk Characterization. Laboratory Animal Studies: Neurotoxicity. Peer Review Workshop on EPA’s Draft. Sacramento, CA, March 5, 2002.

Principles of Neurotoxicology. In Research Infrastructure in Minority Institutions (RIMI) Director’s Meeting Symposium, Baltimore, MD, March 17, 2002.

Blood-Brain Barrier Transport of Metals: Implications in CNS Homeostasis of Essential and Nonessential Metals. In: Innovation in Toxicological Sciences, Blood-Brain Barrier Transport of Metals: Implications in CNS Homeostasis of Essential and Nonessential Metals, Society of Toxicology, Nashville, TN, March 21, 2002.

Astrocyte-Mediated Methylmercury Toxicity. In: Mercury in the Environment: Assessing and Managing the Multimedia Risk. SETAC, Orlando, FL, April 9, 2002.

Manganese Transport and Mechanisms of Neurotoxicity. Texas A & M University, College Station, TX, April 15, 2002.

Manganese Transport and Mechanisms of Neurotoxicity. University of Washington, Seattle, WA, May 16, 2002.

Inhaled manganese and oxidative-stress related endpoints in the rat brain. The Seventh International Highway and Urban Pollution Barcelona, Spain, May 22, 2002.

Manganese Transport and Mechanisms of Neurotoxicity. Kennedy Krieger Institute, Johns Hopkins University, Baltimore, MD, June 5, 2002.

Health Canada Symposium Neurotoxicology. Role of Gene Expression in Toxicology, Canadian Federation of Biological Societies (CFBS, 45th Annual Meeting), Montreal, Quebec, Canada, June 13, 2002.

Chlorpyrifos Transport across Rat Brain Endothelium 4 Monolayers. In: Confronting Neurotoxicology: Genetics, Environment and Behavior. 8th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health, Brescia, Italy, June 25, 2002.

Acrylamide Neurotoxicity: Differentiating between Astrocytomas and Astrogliosis. In: SNF sa Industry Briefing, St. Gregory’s Hotel, Washington, DC, August 8, 2002.

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Manganese Neurotoxicity and Glutamate, In: Glutamine, Glutamate, and GABA in the CNS: Transport and Metabolism in Health and Disease. Wierzba, Poland, August 28, 2002.

Manganese Transport into the Brain: Interactions with Other Metals. Department of Biomedical Sciences, Iowa State University, Ames, IA, September 5, 2002.

The Acute Effects of Acrylamide on Astrocyte Functions. Sixth International Conference on Neuroprotective Agents, Hilton Head, SC, September 18, 2002.

Acrylamide Neurotoxicity. In: SNF sa Industry Briefing, Brussels, Belgium, October 10, 2002.

Transport and Neurotoxic Mechanisms of Manganese in the Brain. Seminar, University of Rochester, October 24, 2002.

Manganese Transport & Speciation in the Central Nervous System (CNS) In: Oxidative Injury and CNS Toxicity. International Society for the Study of Xenobiotics, Orlando, FL, October 29, 2002.

Keynote Speaker, The Neuron-Glia Unit in Neuropathology: Is it a Double-Edged Sword? In: Fourteenth General Assembly of the Japanese Society of Cerebral Blood Flow and Metabolism, Ohmiya, Saitama, Japan, November 14, 2002.

Blood-Brain Barrier Transport of Uranium. Department of Defense Workshop on Depleted Uranium, Albuquerque, NM, December 5, 2002.

Manganese Transport & Speciation in the Central Nervous System (CNS). Invited Speaker, Seminar, Department of Physiology at Ben-Gurion University, Beer Sheba, Israel, December 12, 2002.

2003 Metal Neurotoxicity: New Insights into Neurodegeneration. Tutorial, Neuroscience Program, Wake Forest University School of Medicine, Winston-Salem, NC, February 14, 2003.

Glial Cultures, In: Continuing Education Course, Society of Toxicology, Salt Lake City, UT, March 9 2003.

Why is the Brain so Vulnerable to Toxins? In: Prescription for Science Literacy Workshop, "Chemicals, the Environment, and You: Explorations in Science and Human Health". Wake Forest University School of Medicine, April 2, 2003.

Metal Neurotoxicity. Department of Physiology and Pharmacology, Wake Forest University Health Sciences Center, April 24, 2003.

The role of Metallothionein in Protecting against Metal Neurotoxicity. In: Zinc Signaling, Cayman Islands, May 5, 2003.

Manganese (Mn) and Iron (Fe) Deficiency in Neurodegeneration. In: Role of Diet and Nutrition in Neurotoxicity, 9th International Neurotoxicology Association meeting, Dresden, Germany, June 23 2003.

Astrocyte-Mediated Methylmercury-Induced Toxicity. Environmental Health Science Center, University of Rochester School of Medicine and Dentistry, September 4, 2003.

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Principles of Neurotoxicology: What Accounts for the Exquisite Vulnerability of the CNS to Toxins? Scandinavian In Vitro Toxicology Society, Murikka, Finland, September 19-21, 2003.

Astrocyte-Mediated Methylmercury-Induced Toxicity. Department of Neuroscience, University of Trondheim, Trondheim, Norway, September 22, 2003.

Perchlorate Neurotoxicity, University of Nebraska Medical Center PS3 Symposium, Omaha, NE, September 29, 2003.

2004 Manganese Toxicity, Transport, and Speciation in the CNS. Department of Biochemistry, Molecular Toxicology program, Vanderbilt University, Nashville, TN, January 19, 2004.

Manganese Toxicity, Transport, and Speciation in the CNS. Asian-Pacific Society of Neurochemistry, Hong Kong, February 4, 2004.

Workshop: Mechanisms of Methylmercury Toxicity – The Latent Phase. 21st International Neurotoxicology Conference (NTX XXI). Honolulu, Hawaii, February 12, 2004.

Manganese Transport and Speciation in the CNS. Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal, March 2, 2004.

Transport of Manganese across the Blood-Brain-Barrier, its Distribution and Speciation in the CNS and Possible Mechanism(s) of Neurotoxicity. In: Health Effects, Clinical Research, and Industrial Hygiene Issues in Occupational Manganese Exposure. Conference sponsored by the U.S. Association of Occupational and Environmental Clinics and Tulane University Medical School, New Orleans, LA, April 17, 2004. The Role of Metallothioneins in Heavy Metal Neurotoxicity, In: Second International Meeting for Autism Research (IMFAR); Special Symposium on Autism, Genes, and the Environment, Sacramento, CA, May 7, 2004.

Manganese Transport and Speciation in the CNS. MetaPhore Pharmaceuticals, Inc., St. Louis, MO, May 13, 2004.

Manganese Transport and Speciation in the CNS and its Implications for Neurodegeneration. In: Environmental Factors in Neurodegenerative Disorders, National Institute of Environmental Health Sciences, Research Triangle Park, NC, June 2, 2004.

Manganese Transport and Speciation in the CNS. In: Toxicology Forum, Aspen, CO, July 21, 2004.

Why is the Brain so Sensitive to Injury? Molecular Toxicology NIEHS Outreach Program, Videoconferencing with local and other US high schools. September 28, 2004.

Manganese Transport and Speciation in the CNS. Apoptosis Research Group, Vanderbilt University Medical Center, October 12, 2004.

Heavy Metals and Neurotoxicity, Open House, Center in Molecular Toxicology, Vanderbilt University Medical Center, October 30, 2004.

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Transport and Oxidative Stress Measurements upon Manganese Exposure, EPA/Afton Briefing, CIIT CHS (Chemical Industry Institute of Toxicology, Center for Health Sciences), Research triangle Park, NC, November 4, 2004.

The Acute Effects of Acrylamide on Astrocyte Functions. Seventh International Conference on Neuroprotective Agents: Clinical and Experimental Aspects. Monterey, CA, November 17, 2004.

2005 Neurotoxicology at Vanderbilt: The Future. Molecular Toxicology Center Retreat, Nashville, TN, January 22, 2005.

Developmental Effects of Mercury: Emphasis on Glial Effects. Cure Autism Now (CAN), White Matter Think Tank, Malibu, CA, February 4, 2005.

Live Broadcast, The Link between Environmental Mercury and Autism, "AirTalk," Larry Mantle http://www.scpr.org/programs/airtalk/index.shtml, 89.3 KPCC FM, Pasadena, CA, March 21, 2005.

Thimerosal and Autism: The Vaccine Factor. In: Media Fellowship, Living with Autism: Rates, Causes and Treatment. Vanderbilt Children’s Hospital, Nashville, TN, April 12, 2005.

Manganese transport, Speciation and Toxicity in the Brain, Seminar at Environmental and Occupational Health Science Institute, Rutgers University, Piscataway, NJ, April 14, 2005.

Manganese transport, Speciation and Toxicity in the Brain, Molecular Toxicology Center, Vanderbilt University Medical Center, Nashville, TN, April 18, 2005.

Manganese Transport and Speciation in the CNS, Seminar at the Department of Pharmacology and Toxicology, Indiana University School Of Medicine, Indianapolis, Indiana, April 19, 2005.

Manganese-Induced Oxidative Damage in the CNS, Oxidative Injury Research Group, Vanderbilt University Medical Center, Nashville, TN, May 12, 2005.

Metal Accumulation in Globus Pallidus, NINDS and NIH ORD Second Scientific Workshop on Neurodegeneration with Brain Iron Accumulation (NBIA), Gaithersburg, MD, May 19, 2005.

Outline of Research Program. Center in Molecular Toxicology Meeting with Oak Ridge National Laboratory, Vanderbilt University Medical Center, Nashville, TN, June 13, 2005.

What Do We Know about the Neurotoxicity of Thimerosal? Discussant, in: Oxidative Stress in Autism, Brain research Institute of NY, Staten Island, NY of June 16, 2005

Manganese Transport, Speciation, and Neurotoxicity. Department of Pediatrics, Vanderbilt University Medical Center, Vanderbilt Children’s Hospital, Nashville, TN, June 20, 2005.

Manganese Transport, Toxicity and Speciation in the CNS. American Society of Neurochemistry, Madison, WI, June 26, 2005.

The Neurotoxicity of Manganese, Mechanisms and Speciation. In: Vulnerability of Brain Barriers to Toxicants and Disease, International Neurotoxicology Association (INA) 10, Porvoo, Finland, June 30, 2005.

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Manganese Transport, Speciation and Toxicity in the Central Nervous System. In: Welding Conference, Morgantown, WV, July 23, 2005.

Manganese Transport, Toxicity and Speciation in the CNS. University of Porto Alegre, Brazil, August 22, 2005.

Mercury Neurotoxicity. University of Porto Alegre, Brazil, August 22, 2005.

Manganese Transport, Toxicity and Speciation in the CNS. University of Santa Maria, Brazil, August 24, 2005.

Mercury Neurotoxicity. University of Santa Maria, Brazil, August 24, 2005.

Manganese Transport, Speciation and Toxicity in the Central Nervous System, In: Glutamate in metabolism and neurotransmission: complex interactions at the inter- and intracellular level, Wierzba, Poland, August 29, 2005.

Manganese Transport in the Central Nervous System. In: Environment and Neurodevelopmental Disorders, Twenty-Second International Neurotoxicology Conference, Research Triangle Park, NC, September 14, 2005.

Neurotoxicity of Metals. Open House, Molecular Toxicology Center, Vanderbilt University Medical Center, Nashville, TN, October 1, 2005

Manganese Transport, Speciation and Toxicity in the Central Nervous System, MT-2005, Beijing, China, October 9, 2005.

Manganese Transport, Neurotoxicity and Speciation in the Brain. In: Southeastern Chapter of the Society of Toxicology, Meharry Medical College, Nashville, TN, October 21, 2005.

Manganese Neurotoxicity. Celebrating the Stahlman Chairs, in honor of Dr. Mildred Stahlman and family, Vanderbilt University Medical Center, Nashville, TN, November 21, 2005.

Use of magnetic resonance imaging (MRI) to determine brain manganese deposition in male Sprague Dawley rats. In: Annual meeting of the Israel Society for Neuroscience, Eilat, Israel, December 13, 2005.

Manganese transport, speciation and neurotoxicity, Zlotowski Center, Invited Senior Investigator lecture, Faculty of Health Sciences, Ben-Gurion University of the Negev, December 15, 2005.

2006 Manganese Transport, Toxicity and Speciation in the CNS. In: Winter Conference on Brain Research, Steamboat Springs, CO, January 21-27, 2006.

Developmental Neurotoxicity of Manganese. In: Grand Rounds, the Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, February 1, 2006.

Distribution of Metals: Role of Metal Transporters and Selectivity of Disposition. In: Essentials of Metal Toxicology, Continuing Education Course, Society of Toxicology Annual Meeting, San Diego, CA, March 5, 2006.

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Dietary Iron Modulates Manganese Neurotoxicity. In: Society of Toxicology Annual Meeting, Symposium on Determinants of Manganese Neurotoxicity: From Worms to Man. San Diego, CA, March 8, 2006.

Dietary Iron Modulates Manganese Neurotoxicity. In: Mn in CNS neurotoxicity and idiopathic Parkinson's disease, colloquium for the 37th annual meeting of the American Society for Neurochemistry (ASN), Portland, OR, March 14, 2006.

Manganese Neurotoxicity, Superfund Working Group, Oak Ridge National Laboratory, Oak Ridge, TN, March 22, 2006.

Seminar, Mercury Transport and Mechanisms of Neurotoxicity, Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT, March 24, 2006.

Seminar, Manganese Transport, Toxicity and Speciation in the CNS, Center for Environmental Health in Northern Manhattan, Mailman School of Public Health, Columbia University, New York, NY, March 30, 2006.

Seminar, Mercury Transport and Mechanisms of Neurotoxicity, Waisman Center, Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI , April 12, 2006.

Overview of the Manganese Research Health Program, Site Visit Team to Zunyi Medical College, Zunyi, China, April 17, 2006.

Seminar, Manganese Transport, Mechanisms of Neurotoxicity, and Speciation. Department of Pharmacology, Zunyi Medical College, Zunyi, China, April 17, 2006.

Seminar, Manganese Transport, Toxicity and Speciation in the CNS, School of Public Health, Fudan University, Shanghai, China, April 19, 2006.

Mercury Bioindicators/Biomarkers, 4th International Conference on Environmental Bioindicators, Conference Center at the Maritime Institute, Linthicum Heights, Maryland. April 24, 2006

Brain Accumulation of Depleted Uranium (DU) in Rats Following 3- or 6-Month Treatment with Implanted DU Pellets, In: Military Health Research Forum, San Jose, Puerto Rico, May 2, 2006.

Manganese Transport, Toxicity and Speciation in the Nervous System: Recent Advances. Department of Environmental Health, University of Cincinnati, OH, May 10, 2006.

Seminar, Manganese Transport, Toxicity and Speciation in the CNS, Department of Pharmacology, University of North Dakota, Grand Forks, ND, May 12, 2006.

Manganese: Transport and Mechanisms of Neurotoxicity, 9th International Symposium on Metal Ions in Biology and Medicine, Lisbon, Portugal, May 22, 2006.

Manganese: Transport and Mechanisms of Neurotoxicity, International Conference of Occupational Health (ICOH) 2006, Fiera Milano Congressi, Milan, Italy, June 14, 2006.

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Developmental Neuropathology of Environmental Agents: The Issues of Silent Neurotoxicity, Society of Toxicological Pathology, Vancouver, Canada, June 18, 2006.

Astrocyte-Neuron Interaction is altered by methylmercury (MeHg) and plays a major role in neurotoxicity. Brazilian Society of Biochemistry and Molecular Biology, Águas de Lindóia, San Paolo, Brazil, July 2, 2006.

Astrocyte-Neuron Cross-Talk is Modulating Methylmercury Neurotoxicity. In: Cell-cell Interactions in Organ System Toxicity, Gordon Conference, Colby College, New London, ME, July 27, 2006.

Neurotoxic Mechanisms of Heavy Metals: Ongoing Studies. Presentation for visiting personnel from CFD Research Corporation, Huntsville, AL. Vanderbilt University Medical Center, Nashville, TN, August 19, 2006.

Seminar, the Neurotoxicity of Manganese. In: Molecular Toxicology Center, Vanderbilt University Medical Center, Nashville, TN, August 21, 2006.

Changes in Dietary Iron Levels Affect Brain Manganese Accumulation and Distribution. In: International Neurotoxicology Conference, Little Rock, AR, September 20, 2006.

Manganese: Transport and Mechanisms of Neurotoxicity. 4th Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. Morgantown, WV, September 26, 2006.

Seminar, Manganese: from Worms to Humans, Department of Veterinary Science, University of Wyoming, Laramie, WY, October 26, 2006.

2007 Manganese: Transport and Mechanisms of Neurotoxicity. University of Haifa School Public Health, Haifa, Israel, January 7, 2007.

Manganese: Transport and Mechanisms of Neurotoxicity. Division of Environmental Sciences, Tel Aviv University, Sakler School of Medicine, Tel Aviv, Israel, January 10, 2007.

Future Directions for the SBRP and MHRP. Molecular Toxicology Center Retreat. Vanderbilt University Medical Center, Nashville, TN, January 27, 2007.

Manganese: Transport and Mechanisms of Neurotoxicity. The 40th Annual Winter Conference on Brain Research (WCBR), Snowmass, CO, January 31, 2007.

Neurotoxic Mechanisms of Mefloquine. Walter Reed Institute of Research, Silver Springs, MD, February 9, 2007.

Future Directions for the SBRP and MHRP. Molecular Toxicology Center External Advisory Board meeting, Vanderbilt University Medical Center, Nashville, TN, February 14, 2007.

Manganese: Transport and Mechanisms of Neurotoxicity. Annual MARC U*STAR/Howard Hughes Medical Institute Undergraduate Scholars Program Seminar Series. University of Maryland, Baltimore County (UMBC), March 6, 2007.

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Distribution, Classifications, and Biological Roles of Metallothioneins. 11th meeting of the International Neurotoxicology Association (INA), Asilomar Conference Grounds, Pacific Grove, CA, June 11, 2007.

The Neurotoxicity of Heavy Metals. In: Infections and Brain Disorders. Inter Continental Hotel, Lusaka, Zambia, June 15, 2007.

Manganese and Neurodegeneration. Symposium on Metals and Neurodegenerative Diseases, International Congress of Toxicology (ICT)-XI, Montreal, Canada, July 17, 2007.

Mercury in Neurological Disorders. International Academy of Oral Medicine and Toxicology (IAOMT), Las Vegas, NV, September 8, 2007.

Manganese: Transport and Mechanisms of Neurotoxicity. Department of Neuroscience, University of New Mexico, Albuquerque, NM, October, 4-7, 2007

Changes in Dietary Iron Levels affect Brain Manganese Accumulation and Distribution. Joint meeting of the International Society for Trace Element Research in Humans, the Hellenic Trace Element Society, and The Nordic Trace Element Society. Conference on Trace Elements in Diet, Nutrition and Health: Essentiality and Toxicity. Hersonissos, Crete, October 24, 2007.

C. Elegans in Toxicology: High Throughput Testing. In: Use Of Non-Mammals for Toxicological and Drug Discovery Studies. American College of Toxicology, Charlotte, NC, November 12, 2007.

Manganese: Transport and Mechanisms of Neurotoxicity. Integrated Toxicology and Environmental Health Program, Duke University Medical School, Durham, NC, December 7, 2007.

2008 Role of Microglia in Metal Toxicity. In: Metals, Microglia, and Neuroinflammation. Society of Toxicology, Seattle, WA, March 17, 2008.

Manganese: Transport and Mechanisms of Neurotoxicity. Department of Neurobiology and Neurotoxicology, Meharry Medical College, Nashville, TN, April 21, 2008.

Metals in Autism Spectrum Disorder, Marino Autism Research Institute (MARI) Scientific Symposium Environment and Autism Etiology, Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, April 22, 2008.

Manganese Transport into the Brain: Putative Mechanisms.10th international Symposium on Metal Ions in Biology and Medicine. Bastia, Corsica, May 19-22, 2008.

Gene-Environment Interaction in Manganese-Induced Neurotoxicity, 10th International Symposium on Neurobehavioral Methods and Effects in Environmental and Occupational Health. Heredia, Costa Rica, June 11-13, 2008.

Metals and Neurodegenerative Disorders. MRB-IV Inauguration. Vanderbilt University Medical Center, Nashville, TN, June 17, 2008.

Neurotoxicity of Manganese. Syngenta-Sponsored Workshop on the Basal ganglia. Chicago, IL, July 28-29, 2008.

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Glutamate and Mechanisms of Manganese Neurotoxicity. In 4th Wierzba Meeting, the Tripartite Synapse: Functional and Metabolic Relations in Norm and Pathology. Wierzba, Poland, August 26, 2008.

Transport and Mechanisms of Toxicity of Mercury and Manganese: From Worms to Humans, In: XLIX Congress, Metal Toxicity and the Impact on Human Health, Remedies and Rationale, Pittsburgh, PA, October 1, 2008.

Manganese (Mn) transport at the Blood-Brain Barrier: Implications for Parkinson's-Like Disease, In: Ehrlich II, 2nd World Conference, Nuremberg, Germany, October 4, 2008.

Manganese Transport and Neurotoxicity. International Neurotoxicology Conference, University of Rochester School of Medicine and Dentistry, Rochester, NY, October 13, 2008.

C. elegans: an Emerging Complimentary Platform for Studies on Gene Environment Interactions. International Neurotoxicology Conference, University of Rochester School of Medicine and Dentistry, Rochester, NY, October 14, 2008.

Manganese Transport and Neurotoxicity. Molecular Toxicology Center, Vanderbilt Medical Center, Nashville, TN, October 20, 2008.

Manganese Transport and Neurotoxicity: from Worms to Humans. Oklahoma State University, OK, October 23, 2008.

Restless Leg Syndrome: Insights from Studies on a Related Metal, Manganese. Restless Legs Syndrome (RLS) Scientific Conference, Baltimore, MD, October 27, 2008.

C. elegans: an Emerging Complimentary Platform for Studies on Gene Environment Interactions. National Center for Toxicological Research (NCTR), Jefferson, AR, November 5, 2008.

Manganese Neurotoxicity: Mechanisms of transport and Neurotoxicity. Department of Public Health Sciences, University of Modena and Reggio Emilia, Italy, November 13, 2008.

Mechanism of Manganese Transport and Neurodevelopmental Injury: From C. elegans to Humans. Department of Human Physiology and Pharmacology, Sapienza, University of Rome, Italy, November 19, 2008.

2009 General Neurotoxicology: What Makes the Nervous System so Vulnerable to Chemical Injury, Master’s Neurotoxicology Course, Almeria, Spain, January 27, 2009.

Glial Cultures: Advantages and Disadvantages of Tissue Cultures, Master’s Neurotoxicology Course, Almeria, Spain, January 28, 2009.

Mechanisms of manganese neurotoxicity and commonalities with Parkinson’s disease, Master’s Neurotoxicology Course, Almeria, Spain, January 28, 2009.

Mechanisms of mercury neurotoxicity and relationship to neurodegenerative diseases including autism, Master’s Neurotoxicology Course, Almeria, Spain, January 29, 2009.

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C. elegans as a model for toxicological studies, Master’s Neurotoxicology Course, Almeria, Spain, January 29, 2009.

Mechanism of Manganese Transport and Neurodevelopmental Injury: From C. elegans to Humans. Department of Environmental and Radiological Health Sciences. Colorado State University, Fort Collins, CO, February 4, 2009.

Manganese Neurotoxicity: From C. elegans to Humans. Oregon Health & Science University (OHSU) and the Center for Research on Occupational and Environmental Toxicology (CROET). February 9, 2009.

The Role of Dopamine in Manganese-Induced Neurotoxicity. Symposium on Gene x Environment Interactions, 29th International Conference on Occupational Health (ICOH), Cape Town, South Africa, March 22-27, 2009.

Mechanism of Manganese Transport and Neurodevelopmental Injury: from C. elegans to Humans, Neurotoxicology Society (NTS) meeting, Arica, Chile, April 27, 2009.

The Role of Mercury in Neurodegeneration; Pros and Cons. Machu Picchu, Peru, April 30, 2009.

Manganese Transport: Relationship to Iron. Plenary Lecture, In: 3rd International Symposium on Trace Elements in the Food Chain – Deficiency or Excess of Trace Elements in the Environment as a Risk of Health, Budapest, Hungary, May 22, 2009.

C. elegans: An Emerging Complimentary Platform for Studies on Gene Environment Interactions. INA- 12, Jerusalem, Israel, June 7-12, 2009.

Introductory Remarks. In: The Manganese Health Research Program (MHRP) Showcase Conference: New Discoveries – New Directions. Lansdowne Resort, Lansdowne, Virginia June 24, 2009.

Magnetic Resonance Imaging (MRI) of Manganese Accumulation in the Rat Brain Associated with Iron- Deficiency. In: The Manganese Health Research Program (MHRP) Showcase Conference: New Discoveries – New Directions. Lansdowne Resort, Lansdowne, VA, June 24, 2009.

Metals and Neurodegeneration, Gordon Research Conference on Cell Biology of Metals, Salve Regina University, Newport, RI, August 10, 2009.

Manganese Imaging in the Brain: Relationship to Iron Homeostasis. Military Health Research Forum (MHRF) 2009. Kansas City, MO, September 1, 2009

Manganese Transport and Neurotoxicity. Seventh Congress of Toxicology in Developing Countries. Sun City, South Africa, September 8, 2009.

Manganese Transport and Neurotoxicity. Featured Presentation, Western Region COBRE-INBRE Scientific Conference, Big Sky, MT, September 17, 2009.

Manganese Transport and Neurotoxicity. Departamento de Bioquímica, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil, November 10, 2009.

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Obtaining a Postdoctoral Position in the US. Departamento de Bioquímica, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil, November 10, 2009.

Characterization of the Effects of Methylmercury on Caenorhabditis elegans. Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil, November 13, 2009.

Manganese Transport and Neurotoxicity. Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil, November 13, 2009.

2010 Manganese Transport and Neurotoxicity, the Buck Institute for Age Research, Novato, CA, February 19, 2010.

Manganese Transport and Neurotoxicity, Pediatric Research Conference, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical School, Nashville, TN, February 22, 2010.

Metals and Oxidative Impairment in Neurodegenerative Disorders. Workshop, Minerals and Metals: Pros and Cons of Deliberate Exposure. Society of Toxicology, Salt Lake City, UT, March 10, 2010.

Mechanisms of Neurotoxicity of Methylmercury, In: International Symposium on Disturbances of Cerebral Function Induced by Food and Water Contaminants, Catedra Santiago Grisolia, Valencia, Spain, March 23-25, 2010.

Novel Mechanisms of Manganese Transport and Neurotoxicity. 26th International Neurotoxicology Conference, Portland, OR, June 7, 2010.

A Systems Biology Approach to Enable Safe Administration of Mefloquine. Walter Reed Army Institute of Research, Silver Springs, MD, June 10, 2010.

Principles of Neurotoxicology. Master’s Neurotoxicology Course, University of Reus, Reus, Spain, June 15, 2010.

C. elegans as a Model for Manganese Neurotoxicity. Master’s Neurotoxicology Course, University of Reus, Reus, Spain, June 16, 2010.

Mechanisms of Neurotoxicity of Methylmercury. Master’s Neurotoxicology Course, University of Reus, Reus, Spain, June 17, 2010.

Role of Astrocytes in Nervous System Diseases In: Gene Expression, Biomarkers and Glial Cells in Nervous System Diseases. Society of Toxicologic Pathology, Chicago, IL, June 22, 2010.

Manganese Neurotoxicity. Internal Molecular Toxicology Center seminar series. Vanderbilt University Medical Center, Nashville, TN, July 19, 2010.

Manganese-Induced Neurodegeneration: Genetic insights from studies in C. elegans. Annual Meeting Southeastern Chapter, Society of Toxicology. Georgia Center for Continuing Education in Athens, GA, October 11-12, 2010.

Novel Mechanisms of Manganese Transport and Neurotoxicity. Faculty of Pharmacy, Department of Toxicology, Yeditepe University, Istanbul, Turkey, November 12, 2010.

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2011 Comparative Study on the Response of Rat Primary Astrocytes and Microglia to Methylmercury. Minamata City, Japan, January 27-28, 2011.

Neurotoxicology Goes Global: Scientific Collaboration and Mentorship. Society of Toxicology, Merit Award, Washington, DC, March 7, 2011.

C. elegans and the Role of Dopamine in Manganese-Induced Neurodegeneration. Neurotoxicity Research Society Conference, Uspallata, Argentina, April 7-10, 2011.

Comparative Study on the Response of Rat Primary Astrocytes and Microglia to Methylmercury. Neurotoxicity Research Society Satellite Meeting, Iguazu, Argentina, April 11-14, 2011.

Manganese Transport and Neurotoxicity. Center for Substance Abuse Research, Temple University, Philadelphia, PA, May 3, 2011.

Differential Sensitivity of Astrocytes and Microglia to in vitro Acrylonitrile Treatment. Acrylonitrile Group meeting, Vanderbilt University Medical Center, Nashville, TN, May 16-17, 2011.

C. elegans and the Role of Dopamine in Manganese-Induced Neurodegeneration. International Neurotoxicology Association, INA13, Xi’an, China, June 5-10, 2011.

Principles of Neurotoxicology. University Rovira i Virgili, Tarragona, Spain, June 14, 2011.

Caenorhabditis Elegans as a Model for Toxicological Studies. University Rovira i Virgili, Tarragona, Spain, June 15, 2011.

Keynote, Role of smf Transporters and Dopamine in Manganese-Induced Neurodegeneration in C. elegans. 11th International Symposium on Metal Ions in Biology and Medicine, Cambridge, UK, June 20-23, 2011(missed the meeting due to flight cancellation).

Future of Toxicology in the 21st Century. The XVII Brazilian Congress of Toxicology, Ribeirão Preto, Brazil, June 24, 2011.

Manganese Transport and Neurotoxicity. The XVII Brazilian Congress of Toxicology, Ribeirão Preto, Brazil, June 25, 2011.

Comparative Study on the Response of Rat Primary Astrocytes and Microglia to Methylmercury. The XVII Brazilian Congress of Toxicology, Ribeirão Preto, Brazil, June 25, 2011.

Manganese Transport and Neurotoxicity: Insights from C. elegans Model. University of Londrina, Londrina, Brazil, June 27, 2011.

Manganese-Induced Glutamate Transporter Impairment in Astrocytes is Reversed by Estrogen. Gordon Research Conference, Cellular & Molecular Mechanisms of Toxicity, Proctor Academy, Andover, NH, August 8-12, 2011.

C. elegans and the Role of Dopamine in Manganese-Induced Neurodegeneration. The 5th International Conference on Metals and Genetics (ICMG2011), Kobe, Japan, September 4-8, 2011.

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C. elegans and the Role of Dopamine in Manganese-Induced Neurodegeneration. Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany, September 30, 2011.

Modes-of-Action (MoAs) to define Develpmental Neurotoxicology tool compounds. Center for Alternatives to Animal Testing – Europe, In: CAAT-Europe workshop: Identification of Relevant Toxicants for Developmental Neurotoxicity, University of Konstanz, Konstanz, Germany, October 4-6, 2011.

C. elegans and the Role of Dopamine in Manganese-Induced Neurodegeneration. International Society of Trace Element Research in Humans (ISTERH), Belek, Turkey, October 16-21, 2011.

2012 Manganese Neurotoxicity – Relationship to Parkinson’s Disease. Center Molecular Toxicology, Community Forum on Parkinson's disease, Vanderbilt Clinic at Hundred Oaks, Nashville, TN, January 16, 2012.

General Neurotoxicology: What Makes the Nervous System so Vulnerable to Chemical Injury. Master’s Neurotoxicology Course, Almeria, Spain, January 23, 2012.

Mechanisms of manganese-induced neurotoxicity and relationship to neurodegenerative diseases. Master’s Neurotoxicology Course, Almeria, Spain, January 24, 2012.

C. elegans as a model for toxicological studies. Master’s Neurotoxicology Course, Almeria, Spain, January 25, 2012.

Control of cellular manganese in humans, in: The control of cellular transition metal ion concentrations. King’s College London, Franklin-Wilkins Building, Waterloo Campus, London, UK, February 29, 2012.

C. elegans and the Role of Dopamine in Manganese-Induced Neurodegeneration. 30th International Congress on Occupational Health (ICOH), Cancun, Mexico, March 18-23, 2012.

C. elegans and dopaminergic neurotoxicity. Southern Sleeping Society, Grand Sandestin Resort, Destin, FL March 30, 2012.

Methylmercury Neurotoxicity: Transport and Neuroprotection. Molecular Toxicology Center, Vanderbilt University Medical Center, April 16, 2012.

Manganese Neurotoxicity: From Worms to Neonates. Howard University, Sperling Memorial Lecture in Toxicology, Washington, DC, April 18, 2012.

Methylmercury Neurotoxicity: Transport and Neuroprotection. Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany, May 7, 2012.

Research on manganese and neurotoxic effects – needs and future directions. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany, May 9, 2012.

Interdependence of Mn and Fe in the Blood and Brain. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany, May 9, 2012

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LECTURES AND PRESENTATIONS: continued

Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model. 2nd International Congress on Deuterium Depletion. Budapest, Hungary, May 18, 2012.

Manganese transport and mechanisms of neurotoxicity: lessons learned from C. elegans. Trieste, Italy, May 21-22, 2012.

From C. elegans to humans: understanding Mn-induced neurodegeneration. Eurotox 2012, Congress of the European Society of Toxicology, Stockholm, Sweden, June 18, 2012

From Worms to Humans: Mechanisms of Manganese Induced Neurotoxicity and Lessons for Dopaminergic Cell Loss. Institut d'Investigació Biomédica de Bellvitge (IDIBELL), Barcelona, July 13, 2012.

From C. elegans to Humans: Understanding Manganese Neurotoxicity. Department of Occupational and Environmental Health, Fourth Military Hospital, Xi’an, China, August 27, 2012.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates, Wayne State University, Detroit, MI, September 7, 2012.

Manganese Neurotoxicity: From Worms to Neonates (Grand Rounds). Department of Preventive Medicine (Co-Sponsored by the MPH Program), Mount Sinai School of Medicine, New York, NY, September 14, 2012.

The Center in Molecular Toxicology. Open House for Undergraduates. Vanderbilt University Medical Center, Nashville, TN, October 6, 2012.

Neurotoxicology: From Worms to Neonates. Open House for Undergraduates. Vanderbilt University Medical Center, Nashville, TN, October 6, 2012.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates, German Society of Minerals and Trace Elements, Karlsruhe, Germany, October 12.

2013 Manganese Neurotoxicity: Lessons from Worms to Human Neonates, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, January 17, 2013.

From C. elegans to Humans: Understanding Mn-induced Neurodegeneration.Superfund Research Program Seminar Series, Duke University. Durham, NC, February 8, 2012.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates, Purdue University, West Lafayette, IN, March 4, 2013.

The Interaction between Genes and the Environment (Metals) in Triggering Brain Diseases. Albert Einstein College of Medicine Fundraisers, Palm Beach, FL, March 20, 2013.

Lessons from Worms to Human Neonates. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY. April 1, 2013.

Manganese Neurotoxicity: Lessons From Worms to Neonates. CanBIC, Georgian Bay, Ontario, Canada, May 24, 2013.

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LECTURES AND PRESENTATIONS: continued

Manganese Neurotoxicity: Lessons from Worms to Human Neonates. 14th International Neurotoxicology Association (INA) meeting, Egmond aan Zee, the Netherlands, June 10, 2013.

Keynote Address. Manganese Neurotoxicity: Lessons from Worms to Human Neonates. 2nd Ibero- American Meeting on Toxicology (IBAMTOX) and Environmental Health, Ribeirão Preto-SP, Brazil, June 17, 2013.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates. Joint NBTS/TS Symposium, In Memory of Patricia Rodier, Ph.D., 2013 Neurobehavioral Teratology Society Annual Meeting, Tucson, AZ, June 24, 2013.

Manganese Neurotoxicity. Department of Biochemistry, Universidade Federal do Pampa (Unipampa), Campus São Gabriel, São Gabriel, Rio Grande do Sul, Brazil, August 15, 2013.

Manganese Neurotoxicity. Winter Conference on Biochemical Toxicology, Department of Chemistry, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil, August 19, 2013.

What can be learned from Worms about Gene x Environment Interactions? International Academy of Oral Medicine and Toxicology (IAOMT), Las Vegas, NV, September 7, 2013.

Manganese Neurotoxicity and Genetic Determinants, Department of Biochemistry, Federal University of Santa Catarina, Florianopolis, Santa Catarine, Brazil, October 30, 2013.

Manganese Neurotoxicity: From Worms to Humans, University of Texas at Austin, Austin, TX, December 5, 2013.

Differential sensitivity of astrocytes and microglia to in vitro acrylonitrile treatment. Acrylonitrile Working Group meeting, Albert Einstein College of Medicine, Bronx, NY, December 16, 2013.

2014 Manganese Neurotoxicity: Gene x Environment Interactions, New York Medical College, Valhalla, NY, March 19, 2014.

What can be learned from the Nematode (C. elegans) about Molecular Targets Associated with MeHg Toxicity? Society of Toxicology, Phoenix, AZ, March 24, 2014.

Redox Signaling and Methylmercury Toxicity, Society of Toxicology, Phoenix, AZ, March 26, 2014.

Manganese (Mn) interaction with Dopaminergic Neurons: Evidence from C. elegans. Society of Toxicology, Phoenix, AZ, March 26, 2014.

Differential Sensitivity of Astrocytes and Microglia to in vitro Acrylonitrile Treatment. Acrylonitrile Science Workshop. Society of Toxicology, Phoenix, AZ, March 27, 2014.

Manganese Neurotoxicity: Gene x Environment Interactions, Department of Pharmacology and Therapeutics, Boston University Medical Center, Boston, MA, April 2, 2014.

Nature and Nurture in Parkinson's Disease: Crosstalk Between Genes and Manganese Neurotoxicity, Oberlin College, Oberlin, OH, April 8, 2014

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LECTURES AND PRESENTATIONS: continued

Nature and Nurture in Parkinson's Disease: Crosstalk Between Genes and Manganese Neurotoxicity, Annual Symposium PPGbioq, University of Unipampa, Uruguaiana, Rio Grande do Sul, Brazil, April 24, 2014.

Manganese Neurotoxicity: Gene x Environment Interactions, 1º Latin-American Congress of Clinical and Laboratorial Toxicology -TOXI-LATIN 2014, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil, April 28, 2014.

Methylmercury Neurotoxicity: Gene x Environment Interactions, 1º Latin-American Congress of Clinical and Laboratorial Toxicology -TOXI-LATIN 2014, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil, April 29, 2014.

Estrogen Attenuates Manganese-Induced Glutamate Transporter Impairment, Glutamate/GABA and Neuro-Glia-Vascular Interplay in Norm and Pathology, Krakow, Poland, May 23, 2014.

Nature And Nurture: Crosstalk Between Genes And Manganese Neurotoxicity. Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, June 4, 2014.

Manganese Neurotoxicity: Lessons From Worms to Neonates. 15th International Symposium on Trace Elements in Man & Animals (TEMA 15), Orlando, FL, June 25, 2014.

Unmasking Silent Neurotoxicity Following Developmental Exposure to Methylmercury. In: Unmasking Silent Neurotoxicity Following Developmental Exposure to Environmental Toxicants. Neurobehavioral Teratology Society, Bellevue, June 30, 2014.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates. Einstein-Montefiore Transdisciplinary Center to Promote Women/Infant Health and Disease Eradication (EMPOWER), Albert Einstein College of Medicine, Bronx, NY, September 8, 2014.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates. Division of Neonatology, Department of Pediatrics, Weiler Hospital, Albert Einstein College of Medicine, Bronx, NY, September 9, 2014.

C. elegans and the role of dopamine in manganese-induced neurodegeneration. 13th International Symposium on Metal Ions in Biology & Medicine, Jackson, MS September 14-18, 2014.

C. elegans and the role of dopamine in manganese-induced neurodegeneration. 8th Conference on Metal Toxicity and Carcinogenesis, Albuquerque, New Mexico, October 26-29, 2014.

Grand Rounds Neurology, Albert Einstein College of Medicine, Bronx, NY, November 6, 2014.

What can be learned from the Nematode (C. elegans) about Molecular Targets Associated with Manganese-Induced Neurotoxicity? 2nd International Conference on Environmental Bioinorganic and Toxicology Research – CEBiTOR, Sao Paolo, Brazil, November 15-19, 2014.

Principles of Neurotoxicology. 2nd International Conference on Environmental Bioinorganic and Toxicology Research – CEBiTOR, Sao Paolo, Brazil, November 15-19, 2014.

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LECTURES AND PRESENTATIONS: continued

Heavy Metal Neurotoxicity. 2nd International Conference on Environmental Bioinorganic and Toxicology Research – CEBiTOR, Sao Paolo, Brazil, November 15-19, 2014.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates. Neuroscience Society of Nigeria (NSN) Conference. University of Ilorin, Nigeria, November 27, 2014.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates. School of Environmental Health Science, Obafemi Awolowo University, Ile-Ife, Nigeria, December 1, 2014.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates. Internal Faculty Seminar, Albert Einstein College of Medicine, Bronx, NY, December 4, 2014.

Early-life exposure to mercury and manganese and the risk for dopaminergic neurodegeneration. Child Health Research Seminar, Mount Sinai University School of Medicine, New York, NY, December 16, 2014.

Early Life Exposure to Manganese: Is it a Risk Factor for Neurodegenerative Diseases. Grand Rounds, New York Medical College, Valhalla, NY, December 17, 2014.

2015 Manganese Neurotoxicity: Lessons from Worms to Human Neonates. Duke University, Integrated Toxicology and Environmental Health Program (ITEHP) Seminar SERIES, Durham, NC, January 8, 2015.

Early Life Exposure to Manganese: Is it a Risk Factor for Neurodegenerative Diseases. University of Florida, Neuroscience Seminar Series, Gainesville, FL, January 22, 2015.

C. elegans as an Alternative in vivo Model. Toxicology Program, Oklahoma State University, Stillwater, OK, e-lecture, February 17, 2015.

The Neurotoxicity of Mercury and Manganese: Multiple Faces, Common Mechanisms. Third International Conference Green Health, Mumbai, India, February 20, 2015.

The Role of Mitochondria in Mercury Induced Toxicity. International Association of Oral Medicine and Toxicology (IAOMT). Rio Grande, Puerto Rico March 7, 2015. (flight to PR cancelled due to inclement weather).

SLC30A10 Is a Cell Surface-Localized Manganese Efflux Transporter, and Parkinsonism-Causing Mutations Block Its Intracellular Trafficking and Efflux Activity. Symposium, Environmental Factors in Neurodegenerative Disease. Forty-Sixth Annual Meeting of the American Society of Neurochemistry (ASN), Atlanta, GA, March 17, 2015.

GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes. Symposium, Glia Amino Acid Transporters in Health and Disease. Forty-Sixth Annual Meeting of the American Society of Neurochemistry (ASN), Atlanta, GA, March 18, 2015.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates. University of New Mexico Health Sciences Center, Cellular and Molecular Basis of Disease Seminar Series. Albuquerque, NM, April 24, 2015.

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LECTURES AND PRESENTATIONS: continued

The Role of skn-1 in Methylmercury-Induced Latent Dopaminergic Neurodegeneration. 15th International Neurotoxicology Association (INA) meeting, Montreal, Canada, June 30, 2015.

Molecular neurotoxicology insights from C. elegans. 15th International Neurotoxicology Association (INA) meeting, Montreal, Canada, June 28, 2015.

Molecular neurotoxicology insights from C. elegans. The Medical Scientist Training Program (MSTP), Albert Einstein College of Medicine, Bronx, NY, July 8, 2015.

Manganese Neurotoxicity: From Worms to Premature Humans. Department of Nutritional Sciences, University of Brasília, Brazil, July 29, 2015.

Manganese Neurotoxicity: From Worms to Premature Humans. Department of Toxicology Management (GGTOX), the National Agency of Health Surveillance (ANVISA), Brasília, Brazil, July 31, 2015.

The Role of Mitochondria in Mercury Induced Toxicity. International Association of Oral Medicine and Toxicology (IAOMT). Las Vegas, NV, September 11, 2015.

Manganese Neurotoxicity: From Worms to Premature Humans. Twelfth International Symposium on Recent Advances in Environmental Health Research. Jackson, MS, September 15, 2015

SLC30A10 and its role in manganese transport in C. elegans. Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC, October 7, 2015.

Manganese Neurotoxicity: From Worms to Premature Humans. Key Note, International Society of Trace Elements Research in Humans (ISTERH), Dubrovnik, Croatia, October 20, 2015.

Neurotoxicology. In 9th Congress of Toxicology in Developing Countries, Natal, Brazil, November 7, 2015.

2016 Mn Neurotoxicity. Food and Extract Manufacturers’ Association. Orlando, FL, February 24, 2016.

Gene SLC30A10 and its role in C. elegans. In: The Role of Gene SLC30A10 on Manganese Homeostasis and Functional Outcomes: Implications for Homeostasis and Neurotoxicity. Society of Toxicology, New Orleans, LA, March 15, 2016.

Mitochondrial TMEM-135 decreases manganese-induced dopaminergic neurodegeneration. In: Mitochondrial Dysfunction As a Pathogenic Mechanism and Therapeutic Target for Neurodegenerative Diseases. Society of Toxicology, New Orleans, LA, March 17, 2016.

Manganese neurotoxicity: from worms to humans. In Sunshine Mini Symposium, Society of Toxicology, New Orleans, LA, March 17, 2016.

Manganese neurotoxicity: from worms to humans. State University of Londrina, Rio Grande Do Sul, Brazil, April 13, 2016.

Manganese neurotoxicity: from worms to humans. University of Santa Catarina, Rio Grande Do Sul, Brazil, April 19, 2016.

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LECTURES AND PRESENTATIONS: continued

Manganese neurotoxicity: From worms to human neonates. Department of Environmental Health Sciences, University of Rochester, Rochester, NY, May 19, 2016.

Manganese neurotoxicity: Lessons from worms to human neonates. School of Public Health, Florida International University, Miami, FL, June 17, 2016.

Manganese-Induced Neurotoxicity: Lessons from Worms. EPICOH, Barcelona, Spain, September 7, 2016.

Methylmercury Neurotoxicity. International Meeting of Environmental Health and Toxicology (IMEHTOX). Riberiao Preto, Brazil, September 11, 2016.

Untangling the Manganese-α-synuclein Web. MANGANESE2016, Mount Sinai Medical Center, New York, NY, September 27, 2016.

Contemporary Methods and Models for Predicting Human Toxicity. Northeast Regional Chapter of the Society of Toxicology (NESOT), Northeastern University, Boston, MA, September 30, 2016.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates. XIV International Congress of Toxicology (ICT) in conjunction with the X Mexican Congress of Toxicology (IUTOX). Merida, Mexico, October 4, 2016.

Twitching Worms in the Big Apple. In: Seeds of Collaboration, Albert Einstein College of Medicine, Bronx, NY, October 20, 2016.

The Role of skn-1 in Methylmercury-Induced Latent dopaminergic Neurodegeneration. In: Pathomechanism of Methylmercury Toxicity -Various target organs of methylmercury, National Institute of Minamata Disease (NIMD), Minamata, Japan, December 6-7, 2016.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates. Vice Chancellor Research (VCR) Distinguished Seminar Series, University of Tennessee Health Sciences Center, Memphis, TN, November 29, 2016.

Manganese Neurotoxicity: Lessons from Worms to Human Neonates. University of Para, Belem, Brazil, December 15, 2016.

Methylmercury Neurotoxicity: Gene x Environment Interactions. University of Para, Belem, Brazil, December 15, 2016.

2017 Town Hall Meeting. University of Rochester School of Medicine and Dentistry. Rochester, NY, January 12, 2017.

Manganese Neurotoxicity; Lessons from Worms. In: Expanding C. elegans Research: First Latin American Worm Meeting Institut Pasteur, Latin American Society for Developmental Biology, Montevideo, Uruguay, February 22-24, 2017

Sex- and structure-specific differences in antioxidant responses to methylmercury during early development. International Neurotoxicology Association, Florianopolis, Brazil, May 24, 2017.

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MENTORING:

GRADUATE STUDENTS 1992-1996 Domenico Vitarella. Astrocytic Involvement in Methylmercury Neurotoxicity and Neuroprotection. Ph.D. Thesis, Department of Pharmacology & Toxicology, Albany Medical College, Albany, NY. 1994 Hera Sambaziotis - M.S. Thesis, the Role of Astrocytic Metallothioneins in Lead Poisoning. School of Public Health, State University of New York at Albany, Albany, NY. 1995-1996 Sheryl Stark. M.S. Thesis, Metallothionein Induction in Neonatal Rat Primary Astrocyte Cultures by Acidosis. Neuroscience Program, Wake Forest University School of Medicine, Winston-Salem, NC. 1997-2000 Jeffrey Allen – Ph.D. candidate, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC. 1997-2001 Denise Lewis – Ph.D. candidate, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC (Co-advisor with Dr. Kent Vrana). 2003-2004 Ashley Donahue– Ph.D. candidate, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC (Co-advisor with Dr. William Sonntag). 2004-2007 Jiang, George Chih-Thai, Ph.D. candidate, Department of Physiology and Pharmacology, matriculated at Wake Forest University School of Medicine, Winston-Salem, NC. 2004-2008 Catherine Au – M.S., Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN. 2005-2010 Kirsten Helmcke - Ph.D. candidate, Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN. 2007-2011 Mingwei Ni - Ph.D. candidate, Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN. 2009-2011 Jennifer Madison - Ph.D. candidate, Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN. 2009-2012 Margaret Adams – M.S. candidate, Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN. 2009-2015 Sudipta Chakraborty - Ph.D. candidate, Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN. 2011-2012 Anna Griffin – M.S. candidate, Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN. 2011-present Thuy Tuong Nguyen - Ph.D. candidate, Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN. 2012-present Megan E Culbreth – Ph.D. candidate, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY. 2012-2013 Vivian Santos - Ph.D. candidate, Ribeirão Preto University of São Paulo, Ribeirão Preto, São Paulo, Brazil. 2012-2013 Patrícia Reckziegel - Ph.D. candidate, Department of Biochemistry, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. 2013-2014 Priscila Gubert - Ph.D. candidate, Department of Biochemistry, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. 2013-2014 Tanara Peres - Ph.D. candidate, Department of Biochemistry, University of Santa Catarina, Florianopolis, Brazil.

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MENTORING (CONTINUED):

GRADUATE STUDENTS 2014-present Mahfuz Miah – Ph.D. candidate, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 2014-present Leticia Arantes - Ph.D. candidate, Department of Biochemistry, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.

HIGH SCHOOL STUDENTS 2014 Harold Ekeh, Junior, Elmont Memorial High School, Elmont, Long Island, NY. Research conducted in our lab over the summer of 2014 qualified him as Intel Science Talent Search Semifinalist.

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MENTORING (CONTINUED): VANDERBILT UNIVERSITY MEDICAL CENTER, STUDENT DISSERTATION COMMITTEES (2004 – PRESENT): 2005 Kylee M Spencer, Program in Human Genetics, Vanderbilt University Medical Center, Nashville, TN. 2006-2009 Blairanne Williams, Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN. 2007-2010 Meaghan A Neill, Program in Human Genetics, Vanderbilt University Medical Center, Nashville, TN. 2007-2010 Molly Fricke, Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN. 2009-2011 Gunnar Kwakye, Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN. Chair. 2010-2014 Andrew Tidball Ph.D. candidate, Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN. 2011-2013 Hayley E Boyd-Clay - Ph.D. candidate, Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN. Chair. 2011-2014 Elizabeth Meredith - Ph.D. candidate, Program in Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN. 2011-2014 Laura Hunt - Ph.D. candidate, Program in Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN. 2011-2013 Sara R Savage - Ph.D. candidate, Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN. 2012-2014 Kevin Kumar - Ph.D. candidate, MSTP (M.D./Ph.D.) student, Vanderbilt University Medical Center, Nashville, TN. 2012-present Terry Joe Bichell - Ph.D. candidate, Program in Neuroscience, Vanderbilt University Medical Center, Nashville, TN. 2014 Mestre Vanda Maria Falcäo Espada Lopes de Andrade – Ph.D. candidate, Faculty of Pharmacology, University of Lisbon, Lisbon, Portugal. Served on the Examining Jury, September 29, 2014. 2016 Fiona Peris Sampedro Ph.D. candidate, Department of Psychology, Universitat Rovira i Virgili, Tarragona, Spain. Served on the Examining Jury, January 16, 2016.

POSTDOCTORAL TRAINING: 1991-1994 Vijendra Dave, M.D., Division of Neurosurgery, and Department of Pharmacology and Toxicology, Albany Medical College, Albany, NY (Co-advisor, Dr. Harold K. Kimelberg). 1996-1999 Chang Ping Yao, Ph.D., Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC. 2000-2002 Gouri Shanker, Ph.D. Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC. 2001-2003 Keith Erikson, Ph.D. (Penn State University, Hershey, PA), Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC. 2001-2003 Allison Dobson, Ph.D. (University of South Alabama, Mobile, AL), Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, N.C. 2002-2005 Stephanie Garcia, Ph.D. (Duke University, Durham, NC), Department of Physiology and Pharmacology, Wake Forest University School of

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Medicine, Winston-Salem, N.C. (Recipient of NIEHS F32 Individual Award, ES012768)

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MENTORING (CONTINUED):

POSTDOCTORAL TRAINING:

2003-2006 Vanessa Fitsanakis, Ph.D. (Vanderbilt University Medical Center, Nashville, TN), Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, N.C (2003- 2004), and Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (2004-2006). 2005–2011 Zhaobao Yin, M.D. Ph.D. (Taishan Medical University and Shanghai University of Chinese Medicine and Pharmacology), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 2005-2008 Sarah E Owens, Ph.D. (Vanderbilt University Medical Center, Nashville, TN), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 2006-2008 Alexandre Benedetto, Ph.D. (University of Strasbourg, France), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 2007-2011 Marta Sidoryk, Ph.D. (Nencki Medical Research Center, Polish Academy of Sciences, Warsaw, Poland), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 2008-2010 Daiana de Ávila, Ph.D. (University of Santa Maria, Brazil), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 2010-2013 Ebany Martinez-Finley, Ph.D. (University of New Mexico, Albuquerque, NM), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 1st Prize Award – Vanderbilt Postdoctoral Association competition, Biological Science section, April 26, 2011. 1st Prize Award – Metals Specialty Section Post-Doctoral Research Awards, Annual Society of Toxicology Meeting in San Antonio, TX, March 13, 2013. 2010-2013 Stephanie Fretham, Ph.D. (University of Minnesota, Minneapolis, MN), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 2011-present Samuel Caito, Ph.D. (University of Rochester School of Medicine and Dentistry, Rochester, NY), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 2011-2014 Pan Chen, Ph.D. (University of Alabama, Tusculoosa, AL), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 2012-2013 Emily Bisen-Hersh, Ph.D. (Temple University, Philadelphia, PA), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 2012-2013 Julia Bornhorst, Ph.D. (University of Muenster, Muenster, Germany), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 2013-present Nancy Parmalee, Ph.D. (Columbia University, New York, NY), Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY. 2013-2014 Caridad Lopez Granero, Ph.D. (University of Almeria, Almeria, Spain), Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY.

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MENTORING (CONTINUED):

POSTDOCTORAL TRAINING: 2014-present Alessandra Antunes dos Santos, Ph.D., Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil. 2014-present Ziyan Zhang, Ph.D. (University of Kansas, Lawrence, KA), Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY. 2015-present Maria Rosa Chitolina Schetinger, Ph.D. (Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil). Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY. 2015-present Joanna Ruszkiewicz, Ph.D. (Department of Toxicology, University of Warsaw, Poland). Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY. 2015-present Christopher Barnhart, Ph.D. (Department of Environmental Health, University of California at Davis, Davis, CA). Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY.

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MENTORING (CONTINUED):

ALBERT EINSTEIN COLLEGE OF MEDICINE, STUDENT DISSERTATION COMMITTEES (2014 – PRESENT): 2014-present Diana Athonvarangkul, MD/PhD Candidate, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY. 2014-present Lu Xu, PhD Candidate, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY.

PHYSICIAN-SCIENTIST TRAINING: 2008-2011 Mentoring Committee, Julia Dunn, MD, Clinical and Research Fellow, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, Environmental Health Science Scholars Program, NIEHS (K12), Vanderbilt Physician Scientist Development (VPSD) Awards Program. 2009-2013 Mentoring Committee, Tracy McGregor, Instructor, Pediatrics Medical Genetics, Vanderbilt University Medical Center, Nashville, TN, Environmental Health Science Scholars Program, NIEHS (K12), Vanderbilt Physician Scientist Development (VPSD) Awards Program. 2009-2013 Advisor, Nathalie Maitre, MD, Assistant Professor, Department of Pediatrics (Neonatology Division), Vanderbilt University Medical Center, Nashville, TN, Environmental Health Science Scholars Program, NIEHS (K12). 2015- Kecia N. Carroll, MD, MPH, Associate Professor of Pediatrics, Vanderbilt University Medical Center, Nashville, TN

Teaching Responsibilities 2008-2013 Team Leader, Toxicology section of Targets, Systems, and Drug Action (PHAR 320). 2012-2013 BIOCHEM 336, Course Director.

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