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6777 Nancy Ridge Dr., San Diego, CA 92121 | CLIA # 05D1092505 - CAP 7232232 Patent Pending USPTO #62/767,237 6777 Nancy Ridge Dr., San Diego, CA 92121 | CLIA # 05D1092505 - CAP 7232232 Patent Pending USPTO #62/767,237 POWERED BY PATHWAY GENOMICS INTRODUCTION TO YOUR CANNABIS DNA TEST CannabisDNA™ analyzes your DNA to provide you with a set of evidence-based, personalized recommendations for achieving an optimal response to medicinal cannabis, commonly referred to as marijuana. Hemp is also a source of therapeutic cannabis that is currently legal in all 50 states. Using our proprietary algorithm, CannabisDNA™ informs you as to which type of cannabis or cannabis-derived product(s) will most effectively treat your symptoms, enhance your health, and allow you to avoid or minimize unwanted side-effects. Because it reflects your unique genetic makeup, CannabisDNA™ provides you with a truly personalized set of recommendations on how to safely use cannabis to maintain and improve your well-being. HOW YOUR BODY REACTS TO CANNABIS Your genes play a large role in determining how your body and nervous system react to cannabis. Many cannabis components belong to a class of molecules known as cannabinoids, while others belong to a molecular class known as terpenes. THC and CBD, the two most abundant cannabinoids, mediate their physiological effects through a cellular signaling pathway known as the Endocannabinoid System (ECS). The ECS, which is depicted in the figure below, features prominently in a number of physiological systems and biological processes, including metabolism, appetite, pain, sleep, mood, learning and memory, cardiovascular function, gastrointestinal function, the immune system, and neural development. Due a combination of variables including personal genetics and individual health concerns, a cannabis product and/or cannabinoid combination that is optimal for one individual may not be suitable for another person. This is because different strains and cannabinoids are effective at treating different conditions; further, each individual, due to his or her genetics, will tolerate and respond to the components of cannabis in a personalized manner. By accounting for such variables, CannabisDNA™ assesses your predisposition to the effects of cannabis and uses this information to provide you with a detailed, personalized report informing you as to which cannabis strains and products are optimal for your health and well-being. Not only does CannabisDNA™ provide you with an extensive list of available strains and products, it also delves into the chemistry of cannabinoids by addressing factors such as concentration, purity and forms of delivery. Finally, CannabisDNA™ provides you with a scientific overview of the underlying relationship between cannabis and human health and disease. Role of the Endocannabinoid System (ECS) in Health and Disease DISCLAIMER Cannabis is a Schedule 1 Controlled Substance under the Controlled Substance Act (21 U.S.C. 802) ("CSA") and the cultivation, distribution, and possession of cannabis is a crime under federal law. The CSA and other Federal Statutes specifically prohibit persons from possessing, transferring, delivering, or cultivating cannabis within the territorial borders of the United States. The penalties for violation of these laws can be severe and may include incarceration. The United States Supreme Court has held that the Federal Government may still criminalize the production and use of cannabis regardless of whether a particular state within the United States has allowed for possession or use under certain circumstances, including use for medical purposes. See, Gonzalez v. Raich1. This report, which offers health, wellness and cannabis information, is designed for use with the guidance of your medical practitioner and is intended for educational purposes only. You should not rely on this information as a replacement or substitution for professional medical advice, diagnosis, or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional. The use of cannabis while pregnant or breastfeeding may be harmful to both mother and child. Page 1/25 ACCESSION NUMBER : J0720002 NAME/ID : Test Cannabis ACTIVATION CODE : CANIQ-AAAAA DOB SPECIMEN TYPE : Buccal Swab SEX COLLECTED DATE : Jan 1, 2019 ETHNICITY RECEIVED DATE : Jan 7, 2019 REPORT DATE : N/A YOUR RESULTS SUMMARY The following table summarizes your evidence-based recommendations. Please refer to the next section, YOUR DETAILED RESULTS, for a more thorough description of each condition/trait, along with a more detailed explanation of your personal recommendations. THC Tetrahydrocannabinol CBD Cannabidiol THCV Tetrahydrocannabivarin Recommended Cannabinoid Ratio SUGGESTED CONDITIONS/TRAITS OUTCOME THC : CBD : THCV STRAIN Normal THC Metabolism Balanced : Balanced : -One-to-One Metabolizer Normal CBD Metabolism Balanced : Balanced : -One-to-One Metabolizer Moderate- Psychosis and Anxiety Moderate Low : : - Charlotte's Web High Increased Pain Sensitivity Average Balanced : Balanced : -One-to-One Insomnia Average Balanced : Balanced : -One-to-One Extreme Eating Behavior Average Balanced : Balanced : -One-to-One Moderate- Overeating Tendency Above Average Low-High : : High Doug's Varin High THC dependency Average Balanced : Balanced : -One-to-One Moderate- Alcohol Consumption Above Average Low : : - Charlotte's Web High Rapid Caffeine Metabolism Balanced : Balanced : -One-to-One Metabolizer Atopic Dermatitis Average Balanced : Balanced : -One-to-One Clinical Endocannabinoid Average Balanced : Balanced : - One-to-One Deficiency (CED)-Like Disorder Page 3/25 ACCESSION NUMBER : J0720002 NAME/ID : Test Cannabis YOUR DETAILED RESULTS YOUR Normal Intermediate Poor Metabolizer THC METABOLISM RESULT: Metabolizer Metabolizer The cannabinoid delta-9-tetrahydrocannabinol (THC), which is the primary psychoactive component of cannabis, has been shown to elicit both therapeutic benefits and adverse effects in people2,3. Research has demonstrated that an individual’s genetics influences the manner and rate at which THC is metabolized and cleared from the body3,4. For instance, a person who metabolizes THC poorly will take longer to clear THC from his or her system. Upon consuming a given dose of THC, a poor THC metabolizer will be subjected to the effects of THC longer than will a normal THC metabolizer. RECOMMENDATIONS CANNABINOID RATIO CANNABIS PRODUCT(S) CBD:THC STRAINS TINCTURES EDIBLES Balanced:Balanced One-to-One Green Revolution Chocolate Bar CBD/THC 1:1 CBD/ THC 1:1 More strains More tinctures More edibles on page 18 on page 19 on page 20 Because you are a NORMAL THC metabolizer, you need not restrict yourself to particular cannabis compounds or strains. However, cannabis products that deliver approximately equal levels of CBD and THC are more likely to elicit an outcome that balances the effects of each compound. Page 4/25 CANNABIS TERPENE PRODUCTS Terpenes, which constitute a type of cannabis compound that is distinct from cannabinoids, are responsible for generating the distinctive flavors and odors that characterize the cannabis plant. Hundreds of different terpenes define the dynamic taste and aromatic qualities that are associated with the different cannabis strains. Terpenes have also been suggested to play a role in differentiating the effects of cannabis strains. Individual terpenes, which possess distinctive aromas, are associated with certain cannabis effects. For example, some terpenes are associated with relaxation and stress-relief, while others are associated with focus and alertness. Some researchers have proposed that terpenes may contribute to the 'entourage effect' of cannabis. According to this model, terpenes heighten the effects of cannabinoids and other biologically active chemicals present in cannabis16,42,43. Terpenes are also found in fruits, vegetables, flowers, spices, and green tea. Cannabis breeders and researchers are only just beginning to understand the therapeutic potential of terpenes. The following selection guide lists a number of terpenes alphabetically, along with their corresponding flavor profiles and the strains in which they are found. Terpene Flavor Profile Cannabis Strain Beta-Caryophyllene Woody, Spicy, Peppery, Sweet Chemdawg Bubba Kush Girl Scout Cookies White Widow OG Kush Bisabolol/Levomenol Floral ACDC OG Shark Harle-Tsu Pink Kush Headband Borneol Menthol, Minty Easy/K13 Haze Golden Haze Amnesia Haze Camphene Earthy, Woody Mendocino Purps Strawberry Banana Ghost OG Carene Sweet, Citrus, Woody Mega Hash Dragon Haze Eucalyptol/Cineole Spicy, Minty Headband Super Silver Haze Fenchol Woody, Sweet, Lemon OG Kush Banana Kush Geraniol Rose, Fruity, Sweet Master Kush OG Shark Amnesia Haze Great White Shark Afghani Headband Island Sweet Skunk Guaiol Woody, Rose, Guaiacwood Blue Kush Liberty Haze Chocolope Humulene Woody, Earthy Skywalker OG Pink Kush Girl Scout Cookies White Window OG Kush Sour Diesel Headband Limonene Citrus, Lemon, Orange Bubba Kush Trainwreck Lemon Shining Haze OG Kush Sour Diesel Super Lemon Haze Page 20/25 CANNABIS TERPENE PRODUCTS (CONTINUED) Terpene Flavor Profile Cannabis Strain Linalool Floral Red Eyes OG Cookies & Cream Zkittlez Myrcene Earthy, Musky Skunk XL White Widow Blue Dream Green Crack Alien OG Granddaddy Purple Northern Lights Special Kush 1 Nerolidol Floral, Apple, Rose Lemon Kush Covel Sour Diesel Cannatonic Blackberry Ocimene Fruity, Floral Space Queen Chernobyl Golden Goat Strawberry Cough Pinene Pine Royal Jack OG Kush Jack Herer Dutch Treat Romulan Blue Dream Phytol Floral OG Kush Banana Kush Pulegone Peppermint OG Kush Linalool Flowers, Citrus Pink Kush Ingrid Lavender Skywalker OG Headband Terpineol Floral White Widow OG Kush Girl Scout Cookies Jack Herer Terpinolene Woody, Pine Ultra Jack Herer Royal Jack Pineapple Kush Automatic Trans-nerolido Woody, Citrus, Floral Skywalker OG Sweet Skunk Island Jack Herer Page 21/25.
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